ENZON INC
10-Q, 1997-02-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 10-Q


                QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


For Quarter Ended December 31, 1996                 Commission File No. 0-12957
                  -----------------                                     -------


                                   ENZON, INC.
             (Exact name of registrant as specified in its charter)



               Delaware                                      22-2372868
(State or other jurisdiction of                             (IRS Employer
 incorporation or organization)                            Identification No.)

20 Kingsbridge Road, Piscataway, New Jersey              08854
(Address of principal executive offices)              (Zip Code)

                                 (908) 980-4500
              (Registrant's telephone number, including area code:)



Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days.


Yes   X    No


The number of shares of common stock, $.01 par value, outstanding as of February
3, 1997 was 29,215,451 shares.



<PAGE>

PART I FINANCIAL INFORMATION
Item 1. Financial Statements

                           ENZON, INC AND SUBSIDIARIES
                     CONSOLIDATED CONDENSED BALANCE SHEETS
                       December 31, 1996 and June 30, 1996

<TABLE>
<CAPTION>

                                                                         December 31,                    June 30,
ASSETS                                                                       1996                          1996
                                                                -------------------------------------------------------------
                                                                         (unaudited)                        *
Current assets:
<S>                                                                            <C>                       <C>        
  Cash and cash equivalents                                                    $10,351,505               $12,666,050
  Accounts receivable                                                            3,376,915                 2,123,691
  Inventories                                                                      820,441                   985,378
  Other current assets                                                             336,923                   434,318
                                                                             -------------             -------------
     Total current assets                                                       14,885,784                16,209,437
                                                                              ------------              ------------
Property and equipment                                                          16,220,391                15,640,823
  Less accumulated depreciation and amortization                                12,404,047                11,617,690
                                                                              ------------              ------------
                                                                                 3,816,344                 4,023,133
                                                                             -------------             -------------
Other assets:
  Investments                                                                       78,293                    78,293
  Other assets, net                                                                198,970                    55,945
  Patents, net                                                                   1,519,808                 1,597,048
                                                                              ------------              ------------
                                                                                 1,797,071                 1,731,286
                                                                              ------------              ------------
Total assets                                                                   $20,499,199               $21,963,856
                                                                               ===========              ============



LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Accounts payable                                                              $2,907,511                $2,078,924
  Accrued expenses                                                               3,871,054                 4,387,052
                                                                               -----------              ------------
     Total current liabilities                                                   6,778,565                 6,465,976
                                                                              ------------             -------------
  Accrued rent                                                                     933,331                   980,908
  Royalty advance - RPR                                                          1,171,989                 1,600,786
  Other liabilities                                                                    445                     1,728
                                                                           ---------------            --------------
                                                                                 2,105,765                 2,583,422
                                                                              ------------              ------------
Commitments and contingencies

Stockholders' equity:
  Preferred stock-$.01 par value, authorized 3,000,000 shares:
   issued and outstanding 144,740 shares at December 31,
   1996 and 169,000 shares at June 30, 1996 (liquidation
   aggregating $6,299,000 at December 31, 1996 and
   $8,725,000 at June 30, 1996)                                                      1,447                     1,690
  Common stock-$.01 par value, authorized 40,000,000 shares;
   issued and outstanding 29,010,003 shares at December
   31, 1996 and 27,706,396 shares at June 30, 1996                                 290,100                   277,064
  Additional paid-in capital                                                   121,389,101               121,272,024
  Accumulated deficit                                                        (110,065,779)             (108,636,320)
                                                                             -------------             -------------
Total stockholders' equity                                                      11,614,869                12,914,458
                                                                              ------------             -------------
Total liabilities and stockholders' equity                                     $20,499,199               $21,963,856
                                                                              ============              ============

</TABLE>

*Condensed from audited financial statements.

The  accompanying  notes are an integral  part of these  unaudited  consolidated
condensed financial statements.
                                      - 2 -

<PAGE>



                                   ENZON, INC.
                 CONSOLIDATED CONDENSED STATEMENTS OF OPERATIONS
          Three Months and Six Months Ended December 31, 1996 and 1995
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                                Three months ended                           Six months ended
                                                        December 31,          December 31,          December 31,       December 31,
                                                            1996                  1995                  1996               1995

                                                   -------------------------------------------------------------------------------
Revenues
<S>                                                        <C>              <C>                   <C>                   <C>       
  Sales                                                    $3,553,975       $2,541,976            $6,274,566            $5,351,024
  Contract revenue                                              5,010          788,236             1,099,309               904,736
                                                       --------------     ------------            ----------           -----------
     Total revenues                                         3,558,985        3,330,212             7,373,875             6,255,760
                                                         ------------     ------------            ----------           -----------
Costs and expenses
  Cost of sales                                               994,325        1,223,876             1,980,314             2,188,577
  Research and development expenses                         1,980,063        2,390,822             4,409,834             5,081,470
  Selling, general and administrative expenses              1,453,545        1,404,350             2,729,612             2,676,320
                                                           ----------       ----------            ----------            ----------
     Total costs and expenses                               4,427,933        5,019,048             9,119,760             9,946,367
                                                           ----------       ----------            ----------            ----------
       Operating loss                                       (868,948)      (1,688,836)           (1,745,885)           (3,690,607)
                                                          -----------     ------------          ------------          ------------
Other income (expense)
  Interest and dividend income                                162,770           81,734               319,911               184,079
  Interest expense                                            (4,847)          (4,263)              (11,600)              (10,952)
  Other                                                           180        1,318,379                 8,115             1,321,322
                                                         ------------       ----------          ------------            ----------
                                                              158,103        1,395,850               316,426             1,494,449
                                                           ----------       ----------           -----------            ----------
     Net loss                                              ($710,845)       ($292,986)          ($1,429,459)          ($2,196,158)
                                                           ==========       ==========          ============          ============
Net loss per common share                                     ($0.03)          ($0.01)               ($0.05)               ($0.08)
                                                              =======          =======               =======               =======

Weighted average number of common
 shares outstanding during the period                      27,882,828       26,328,874            27,794,716            26,328,874
                                                           ==========       ==========            ==========            ==========
</TABLE>


                                      - 3 -

<PAGE>

                          ENZON, INC. AND SUBSIDIARIES
                 CONSOLIDATED CONDENSED STATEMENTS OF CASH FLOWS
                   Six Months Ended December 31, 1996 and 1995
                                   (Unaudited)
<TABLE>
<CAPTION>

                                                                                            Six Months Ended

                                                                                    December 31,           December 31,
                                                                                        1996                   1995
                                                                           -------------------------------------------------
Cash flows from operating activities:
<S>                                                                                     <C>                 <C>         
  Net loss                                                                              ($1,429,459)        ($2,196,158)
  Adjustment for decrease in liability recognized pursuant
    to Sanofi Winthrop Agreement                                                                -            (1,312,829)
  Adjustment for depreciation and amortization                                               886,729           1,060,971
  Non-cash expense for issuance of common stock and stock options                            121,838                -
  Decrease in accrued rent                                                                  (47,577)             (5,158)
  Decrease in royalty advance - RPR                                                        (428,797)           (207,855)
  Changes in assets and liabilities                                                        (821,328)            (83,597)
                                                                                      --------------         -----------
  Net cash used in operating activities                                                  (1,718,594)         (2,744,626)
                                                                                       -------------        ------------
Cash flows from investing activities:
  Capital expenditures                                                                     (602,700)            (48,307)
                                                                                       -------------        ------------
  Net cash used in investing activities                                                    (602,700)            (48,307)
                                                                                       -------------        ------------
Cash flows from financing activities:
  Proceeds from issuance of common stock                                                       8,032                   -
  Principal payments of obligations under capital leases                                     (1,283)             (1,011)
                                                                                     ---------------      --------------
  Net cash provided by (used in) financing activities                                          6,749             (1,011)
                                                                                      --------------      --------------
  Net decrease in cash and cash equivalents                                              (2,314,545)         (2,793,944)

  Cash and cash equivalents at beginning of period                                        12,666,050           8,102,989
                                                                                        ------------          ----------
  Cash and cash equivalents at end of period                                             $10,351,505          $5,309,045
                                                                                         ===========          ==========
</TABLE>



The  accompanying  notes are an integral  part of these  unaudited  consolidated
condensed financial statements.


                                      - 4 -

<PAGE>



                          ENZON, INC. AND SUBSIDIARIES
              Notes To Consolidated Condensed Financial Statements
                                   (Unaudited)

(1)  Organization and Basis of Presentation
- -------------------------------------------

         The unaudited  consolidated  condensed  financial  statements have been
prepared  from the  books  and  records  of  Enzon,  Inc.  and  subsidiaries  in
accordance with generally accepted  accounting  principles for interim financial
information.  Accordingly,  they  do not  include  all of  the  information  and
footnotes  required by generally  accepted  accounting  principles  for complete
financial statements. In the opinion of management,  all adjustments (consisting
only of  normal  and  recurring  adjustments)  considered  necessary  for a fair
presentation have been included.  Interim results are not necessarily indicative
of the results that may be expected for the year.

(2)  Net Loss Per Common Share
- ------------------------------

         Net loss  per  common  share is based on the net loss for the  relevant
period, adjusted for cumulative undeclared preferred stock dividends of $109,000
for the six months ended December 31, 1996 and 1995, and $55,000 for each of the
three months ended December 31, 1996 and 1995,  divided by the weighted  average
number of shares  issued and  outstanding  during  the  period.  Stock  options,
warrants and common stock  issuable upon  conversion of the preferred  stock are
not reflected as their effect would be  antidilutive  for both primary and fully
diluted earnings per share computations.

(3)  Inventories
- ----------------

         The  composition  of inventories at December 31, 1996 and June 30, 1996
is as follows:

                                   December 31,                June 30,
                                       1996                      1996
                                       ----                      ----

         Raw materials             $375,000                  $206,000
         Work in process            298,000                   383,000
         Finished goods             147,000                   396,000
                                    -------                   -------
                                   $820,000                  $985,000
                                   ========                  ========

(4)  Cash Flow Information
- --------------------------

         The  Company  considers  all highly  liquid  securities  with  original
maturities  of three months or less to be cash  equivalents.  Cash  payments for
interest  were  approximately  $12,000  and  $11,000  for the six  months  ended
December 31, 1996 and 1995, respectively. There were no income tax payments made
for the six months ended December 31, 1996 and 1995.

         During the six months ended December 31, 1996,  24,260 shares of Series
B Convertible  Preferred  Stock were converted  into 1,287,213  shares of Common
Stock.  A cash payment of $2.00 was made for  fractional  shares  related to the
conversions.  During the six months ended  December 31, 1995, the Company issued
150,000  five-year  warrants to purchase the Company's common stock at $2.50 per
share as part of the commission due to the real estate broker in connection with
the  termination of the lease at 40 Kingsbridge  Road.  These  transactions  are
non-cash financing activities.


                                      - 5 -

<PAGE>

                          ENZON, INC. AND SUBSIDIARIES
         Notes To Consolidated Condensed Financial Statements, Continued
                                   (Unaudited)


(5) Significant Agreements
- --------------------------

         During  October 1996,  the Company  entered into a marketing  agreement
with Medac GmbH ("MEDAC") to sell  ONCASPAR(R) in Europe and Russia.  MEDAC will
purchase ONCASPAR from Enzon at a set price which will increase over the term of
the agreement.  The agreement  also contains  certain  minimum  annual  purchase
requirements.

(6)  Non-Qualified Stock Option Plan
- ------------------------------------

         During the six months  ended  December  31,  1996,  the Company  issued
620,000 stock options at an average  exercise price of $2.80 per share under the
Company's  Non-Qualified  Stock Option Plan,  as amended,  of which 150,000 were
granted to executive officers of the Company. None of the options granted during
the period are  exercisable  as of December 31,  1996.  All options were granted
with  exercise  prices  that  equaled or exceeded  the fair market  value of the
underlying stock on the date of grant.

(7)  Independent Directors' Stock Plan
- --------------------------------------

         On December 3, 1996,  the  stockholders  voted to approve the Company's
Independent  Directors'  Stock Plan, which provides for compensation in the form
of quarterly  grants of Enzon common stock to independent  directors  serving on
the Company's Board of Directors. Each independent director is granted shares of
Enzon  common  stock  equivalent  to $2,500 per  quarter  plus $500 per Board of
Director's  meeting  attended.  The number of shares issued is based on the fair
market value of Enzon  common  stock on the last  trading day of the  applicable
quarter.  During the quarter ended  December 31, 1996, the Company issued 12,650
shares  of  Enzon  common  stock to  non-executive  directors,  pursuant  to the
Independent  Directors'  Stock Plan.  The shares  issued  represent  payment for
services  rendered for the period from January 16, 1996  through  September  30,
1996.

(8)  Stockholders' Equity
- -------------------------

         During the six months ended December 31, 1996,  24,260 shares of Series
B Convertible  Preferred  Stock were converted  into 1,287,213  shares of Common
Stock.

(9) Other Income
- ----------------

         During the quarter ended December 31, 1995,  the Company  recognized as
other income  approximately  $1,313,000,  representing  the unused portion of an
advance received under a development and license agreement with Sanofi Winthrop,
Inc.  ("Sanofi").  During October 1995, the Company learned that Sanofi intended
to cease development of PEG-SOD  (Dismutec(TM))  due to the product's failure to
show a statistically  significant difference between the treatment group and the
control  group in a pivotal  Phase III  trial.  Due,  in part,  to this  product
failure,  the Company believes it has no further obligations under its agreement
with Sanofi with respect to the $1,313,000  advance and  therefore,  the Company
reversed the amount due Sanofi previously recorded as a current liability.


                                      - 6 -

<PAGE>

Item 2. Management's  Discussion and Analysis of Financial Condition and Results
of Operations

Information contained herein contains "forward-looking  statements" which can be
identified  by the use of  forward-  looking  terminology  such  as  "believes,"
"expects,"  "may," "will," "should," or "anticipates" or the negative thereof or
other  variations  thereon  or  comparable  terminology,  or by  discussions  of
strategy.  No  assurance  can be given  that the future  results  covered by the
forward-looking  statements  will be achieved.  The matters set forth in Exhibit
99.0 to the Company's  Annual Report on Form 10-K for the fiscal year ended June
30, 1996,  which is  incorporated  herein by  reference,  constitute  cautionary
statements  identifying  important factors with respect to such forward- looking
statements,  including certain risks and uncertainties,  that could cause actual
results  to  vary  materially   from  the  future  results   indicated  in  such
forward-looking  statements.  Other factors  could also cause actual  results to
vary  materially  from the  future  results  indicated  in such  forward-looking
statements.

Results of Operations
- ---------------------

Three months ended December 31, 1996 vs. Three months ended December 31, 1995
- -----------------------------------------------------------------------------

Revenues.  Revenues for the three months ended December 31, 1996 increased by 7%
to  $3,559,000  as  compared  to  $3,330,000  for the same  period in 1995.  The
components of revenues are sales and contract  revenues.  Sales increased by 40%
to  $3,554,000  for the three  months  ended  December  31,  1996 as compared to
$2,542,000 for the same period in the prior year, due to increased revenues from
ONCASPAR,  which is marketed in the U.S. by Rhone-Poulenc Rorer Pharmaceuticals,
Inc.  ("RPR"),  and  increased  ADAGEN(R)  sales  resulting  from an increase in
patients receiving ADAGEN.  ADAGEN sales for the three months ended December 31,
1996 and 1995 were $2,328,000 and $2,039,000,  respectively.  ONCASPAR  revenues
are  comprised  of  manufacturing  revenues  as well as  royalties  on  sales of
ONCASPAR  by RPR.  ONCASPAR  revenues  increased  due to an increase in sales of
ONCASPAR by RPR as well as an increase in the royalty rate to 23.5%, as compared
to 10.0%  during the prior year.  Contract  revenue for the three  months  ended
December  31, 1996  decreased  to $5,000,  as compared to $788,000  for the same
period in 1995. The decrease was principally due to a one-time  payment received
during  the  prior  year  in   connection   with  the  signing  of  a  worldwide
non-exclusive  licensing  agreement  with  RPR  for the  Company's  Single-Chain
Antigen-Binding  ("SCA(R)")  protein  technology.  During the three months ended
December  31,  1996 and 1995,  the  Company  had export  sales of  $639,000  and
$521,000, respectively. Sales in Europe were $529,000 and $460,000 for the three
months ended December 31, 1996 and 1995, respectively.

Cost of Sales. Cost of sales, as a percentage of sales, decreased to 28% for the
three months  ended  December 31, 1996 as compared to 48% for the same period in
1995. The decrease was due primarily to a cash payment in the prior year in lieu
of satisfying the minimum purchase  requirements  under the Company's  long-term
supply  agreement for a raw material used in the  production of ONCASPAR and the
write-off of excess  ONCASPAR raw material  during the prior year,  as well as a
decrease in the charge recorded for the three months ended December 31, 1996 for
idle capacity at the Company's manufacturing facility. While it is possible that
the Company may incur similar losses on its remaining purchase commitments under
the supply  agreement,  the Company does not consider such losses probable,  nor
can the amount of any loss which may be  incurred  in the  future  presently  be
estimated due to a number of factors,  including,  but not limited to, potential
increased  demand for  ONCASPAR  from RPR,  expansion  into  additional  markets
outside the U.S. and the  possibility  that the Company  could  renegotiate  the
level of required purchases.  If the Company does not achieve increases in sales
of ONCASPAR beyond current levels or cannot  renegotiate its commitment,  a loss
would be incurred on the remaining purchase commitment. During the quarter ended
December 31, 1996, the Company utilized  approximately  31% of its manufacturing
capacity for the production of its approved products.

Research and Development. Research and development expenses for the three months
ended December 31, 1996 decreased by 17% to $1,980,000  from  $2,391,000 for the
same period in 1995. This decrease was primarily due to reductions in personnel,
principally in the clinical and  scientific  administration  areas,  and related
costs, such as payroll taxes and benefits,  totaling  approximately $364,000 and
other  cost  containment  measures  implemented  by the  Company  as  part  of a
continued focus on key development programs.

                                      - 7 -

<PAGE>

Selling,   General   and   Administrative   Expenses.   Selling,   general   and
administrative  expenses for the three months ended  December 31, 1996  remained
relatively  consistent at  $1,454,000,  as compared to  $1,404,000  for the same
period in 1995.

Other Income/Expense.  Other income/expense  decreased by $1,238,000 to $158,000
for the three months ended  December 31, 1996 as compared to $1,396,000  for the
same  period  last  year.  The  decrease  was due  principally  to the  one-time
recognition as other income of approximately $1,313,000 during the quarter ended
December 31, 1995,  representing the unused portion of an advance received under
a development and license agreement with Sanofi Winthrop, Inc. ("Sanofi").

Six months ended December 31, 1996 vs. Six months ended December 31, 1995
- -------------------------------------------------------------------------

Revenues.  Revenues for the six months ended  December 31, 1996 increased by 18%
to  $7,374,000  as  compared  to  $6,256,000  for the same  period in 1995.  The
components of revenues are sales and contract  revenues.  Sales increased by 17%
to  $6,275,000  for the six  months  ended  December  31,  1996 as  compared  to
$5,351,000  for the same period in the prior  year,  due to  increased  ONCASPAR
revenues from RPR and an increase in ADAGEN sales  resulting from an increase in
patients  receiving  ADAGEN.  ONCASPAR  revenues are comprised of  manufacturing
revenues as well as  royalties  on sales of ONCASPAR by RPR.  ONCASPAR  revenues
increased  due to an increase in sales of ONCASPAR by RPR as well as an increase
in the royalty rate to 23.5%, as compared to 10.0% during the prior year. ADAGEN
sales for the six months ended  December 31, 1996 and 1995 were  $4,453,000  and
$4,214,000, respectively. Contract revenue for the six months ended December 31,
1996 increased by 21% to $1,099,000, as compared to $905,000 for the same period
in 1995. The increase was due to a one-time $1,000,000 payment,  received during
the six months ended December 31, 1996, from Schering  Corporation  ("Schering")
related to the transfer of know-how for the  manufacturing of PEG-Intron A under
the Company's June 1995 amended Schering  agreement.  Contract  revenues for the
prior year's period  reflected a one-time  payment received in connection with a
worldwide  non-exclusive license for the Company's SCA protein technology signed
with RPR.  During the six months ended  December 31, 1996 and 1995,  the Company
had export sales of $1,271,000  and  $1,162,000,  respectively.  Sales in Europe
were  $1,091,000  and  $1,014,000 for the six months ended December 31, 1996 and
1995, respectively.

Cost of Sales. Cost of sales, as a percentage of sales, decreased to 32% for the
six months  ended  December  31,  1996 as compared to 41% for the same period in
1995. The decrease was due primarily to a cash payment in the prior year in lieu
of satisfying the minimum purchase  requirements  under the Company's  long-term
supply  agreement for a raw material used in the  production of ONCASPAR and the
write-off of excess  ONCASPAR raw material,  as well as a decrease in the charge
recorded  for the six months ended  December  31, 1996 for idle  capacity at the
Company's  manufacturing  facility.  While it is  possible  that the Company may
incur similar  losses on its  remaining  purchase  commitments  under the supply
agreement,  the Company  does not  consider  such losses  probable,  nor can the
amount of any loss which may be incurred in the future  presently  be  estimated
due to a number of factors,  including,  but not limited to, potential increased
demand for ONCASPAR from RPR, expansion into additional markets outside the U.S.
and the  possibility  that the Company could  renegotiate  the level of required
purchases. If the Company does not achieve increases in sales of ONCASPAR beyond
current levels or cannot renegotiate its commitment, a loss would be incurred on
the remaining purchase commitment.

Research and Development.  Research and development  expenses for the six months
ended December 31, 1996 decreased by 13% to $4,410,000  from  $5,081,000 for the
same period in 1995. This decrease was primarily due to reductions in personnel,
principally in the clinical and  scientific  administration  areas,  and related
costs,  such as payroll taxes,  totaling  approximately  $624,000 and other cost
containment  measures implemented by the Company as part of a continued focus on
key development programs.

                                      - 8 -

<PAGE>

Selling,   General   and   Administrative   Expenses.   Selling,   general   and
administrative  expenses  for the six months ended  December  31, 1996  remained
relatively  consistent at  $2,730,000,  as compared to  $2,676,000  for the same
period in 1995.

Other Income/Expense.  Other income/expense  decreased by $1,178,000 to $316,000
for the six months  ended  December 31, 1996 as compared to  $1,494,000  for the
same  period  last  year.  The  decrease  was due  principally  to the  one-time
recognition as other income of approximately $1,313,000 during the quarter ended
December 31, 1995,  representing the unused portion of an advance received under
a development and license agreement with Sanofi.

Liquidity and Capital Resources
- -------------------------------

         Enzon had  $10,352,000 in cash and cash  equivalents as of December 31,
1996.  The  Company  invests  its  excess  cash  in a  portfolio  of  high-grade
marketable securities and United States government-backed securities.

         The  Company's  cash  reserves as of December  31,  1996  decreased  by
$2,315,000  from June 30, 1996.  The decrease in cash reserves was caused by the
funding of  operations  and capital  expenditures  of  $603,000,  related to the
upgrade of the Company's pilot manufacturing facility for PEG-hemoglobin.

         The Company's  exclusive  U.S.  marketing  rights  license with RPR for
ONCASPAR  provides for a payment of  $3,500,000 in advance  royalties  which was
received in January 1995.  Under the  agreement,  as amended,  royalties will be
offset against a credit of $5,970,000, which represents the royalty advance plus
reimbursement  of  certain  amounts  due RPR under the  previous  agreement  and
interest  expense,  before cash payments will be made under the  agreement.  The
royalty advance is shown as a long term liability with the corresponding current
portion  included in accrued  expenses  on the  consolidated  condensed  balance
sheets and will be reduced as  royalties  are  recognized  under the  agreement.
Through  December 31, 1996, an aggregate of  $1,969,000 in royalties  payable by
RPR have been offset against the original credit.

         As of  December  31,  1996,  940,808  shares  of  Series  A  Cumulative
Convertible  Preferred  Stock  ("Series A Preferred  Stock") have been converted
into  3,093,411  shares of the  Company's  common  stock (the  "Common  Stock").
Accrued  dividends on the converted Series A Preferred Stock in the aggregate of
$1,792,000  were settled by the issuance of 232,383 shares of Common Stock.  The
Company  does  not  presently  intend  to pay  cash  dividends  on the  Series A
Preferred  Stock. As of December 31, 1996,  there were $1,476,000 of accrued and
unpaid dividends on the Series A Preferred Stock. These dividends are payable in
cash or Common  Stock at the  Company's  option  and  accrue on the  outstanding
Series A Preferred  Stock at the rate of $218,000  per year.  During the quarter
ended  December 31, 1996,  24,260 shares of the  Company's  Series B Convertible
Preferred  Stock were  converted into  1,287,213  shares of Common Stock.  As of
December  31,  1996,  there had been no  conversion  of the  Company's  Series C
Convertible  Preferred Stock.  Neither the Series B Convertible  Preferred Stock
nor the Series C Convertible Preferred Stock carry stated dividends.

         To date, the Company's  sources of cash have been the proceeds from the
sale of its stock through public and private placements,  sales of ADAGEN, sales
of ONCASPAR, sales of its products for research purposes,  contract research and
development fees, technology transfer and license fees and royalty advances. The
Company's  current  sources of  liquidity  are its cash,  cash  equivalents  and
interest earned on such cash reserves, sales of ADAGEN, sales of ONCASPAR, sales
of its products for research purposes and license fees. Management believes that
its current sources of liquidity will be sufficient to meet its anticipated cash
requirements,  based on current spending levels,  for approximately the next two
years.

         Upon exhaustion of the Company's  current cash reserves,  the Company's
continued  operations will depend on its ability to realize significant revenues
from the commercial sale of its products,  raise additional funds through equity
or debt  financing,  or obtain  significant  licensing,  technology  transfer or
contract  research and  development  fees.  There can be no assurance that these
sales, financings or revenue generating activities will be successful.

                                      - 9 -

<PAGE>

PART II OTHER INFORMATION
- -------------------------

Item 1. Legal Proceedings
- -------------------------

         On January 6, 1997,  Enzon was served with a  complaint  by LBC Capital
Resources,  Inc.  ("LBC"),  that was filed on December 17,  1996,  in the United
States  District  Court  for  the  District  of New  Jersey  (Civil  Action  No.
96-5919(JCL)  asserting that under the May 2, 1995,  letter  agreement  ("Letter
Agreement") between Enzon and LBC, LBC was entitled to a commission comprised of
$500,000 in cash and warrants to purchase 1,000,000 shares of Enzon common stock
at an exercise  price of $2.50 per share in connection  with the 1996  financing
transactions  (collectively,  the  "Financings")  the Company  entered into with
affiliates  of Genesee  Advisors  ("Genesee").  LBC has also asserted that it is
entitled  to an  additional  fee of  $175,000  in cash and  warrants to purchase
250,000 of Enzon common stock when and if Genesee  exercises any of the warrants
obtained pursuant to the Financings.  LBC has claimed $3 million in compensatory
damages, plus punitive damages, counsel fees and costs for the alleged breach of
the Letter Agreement. The Company believes that no such commission was due under
the Letter  Agreement and denies any liability under the Letter  Agreement.  The
Company intends to defend this lawsuit vigorously.

Item 2. Changes in Securities
- -----------------------------

         During the period from November 19, 1996 through December 31, 1996, the
purchaser of 40,000 shares of the Company's Series B Convertible Preferred Stock
in January  1996,  converted  an  aggregate  of 24,260  shares of such  Series B
Convertible  Preferred  Stock into an aggregate  of  1,287,213  shares of Common
Stock at per share conversion prices ranging from $1.83 to $1.96. The conversion
prices  were equal to 80% of the average of the closing bid prices of the Common
Stock for the five consecutive  trading days ending one trading day prior to the
date of such conversion. The Company relied upon the exemption from registration
under the  Securities  Act of 1933,  as amended,  contained  in Section  3(a)(9)
thereof  with  respect  to the  issuance  of such  shares of Common  Stock  upon
conversion of the Series B Convertible Stock.

Item 4. Submission of Matters to a Vote of Security Holders
- -----------------------------------------------------------

(a)  An annual meeting of stockholders was held on December 3, 1996.

(b)  The directors  elected at the annual  meeting were Peter G. Tombros and Dr.
     Rosina B. Dixon.  The term of office as a director  for each of A.M.  "Don"
     MacKinnon,  Randy H. Thurman and Robert LeBuhn  continued  after the annual
     meeting.

(c)  The matters voted upon at the annual meeting and the results of the voting,
     including broker non-votes where applicable, are set forth below.

     (i)The stockholders  voted 23,447,880  shares in favor and withheld 273,020
          votes with  respect to the  election of Peter G.  Tombros as a Class I
          director of the Company and  23,489,276  shares in favor and  withheld
          231,624 votes with respect to the election of Dr. Rosina B. Dixon as a
          Class I director of the Company. Broker non-votes were not applicable.

     (ii) The stockholders  voted 22,229,653  shares in favor,  648,481 against,
          158,792 abstained and there were 683,974 broker non-votes with respect
          to a proposal to approve the  Company's  1996  Independent  Directors'
          Stock Plan,  which will provide for  compensation in the form of Enzon
          common stock for independent directors.

     (iii)The stockholders voted 23,539,597 shares in favor, 100,112 against and
          81,191 abstained with respect to a proposal to ratify the selection of
          KPMG Peat Marwick LLP to audit the  Company's  consolidated  financial
          statements for the fiscal year ending June 30, 1997.  Broker non-votes
          were not applicable.

                                     - 10 -

<PAGE>

Item 6. Exhibit and Reports on Form 8-K
- ---------------------------------------

     (a) Exhibits (numbered in accordance with Item 601 of Regulation S-K).
<TABLE>
<CAPTION>

  Exhibit                                                                                      Page Number
   Number           Description                                                                    or
   ------           -----------                                                               Incorporation
                                                                                              By Reference
                                                                                              ------------
<S>                                                                                           <C>   
 3(i)   Certificate of Incorporation, as amended                                                   ^
3(ii)   By-laws, as amended                                                                     *(4.2)
 10.0   Employment Agreement dated March 25, 1994 with Peter G. Tombros                        #(10.17)
 10.1   Form of Change of Control Agreements dated as of January 20, 1995 entered
          into with the Company's Executive Officers                                            ~(10.2)
 10.2   Lease - 300-C Corporate Court, South
             Plainfield, New Jersey                                                           ***(10.3)
 10.3   Modification of Lease - 300-C Corporate Court, South Plainfield
             New Jersey                                                                        ++(10.3)
 10.4   Lease Termination Agreement dated March 31, 1995 for
          20 Kingsbridge Road and 40 Kingsbridge Road, Piscataway, New Jersey                   ~(10.6)
 10.5   Option Agreement dated April 1, 1995 regarding 20 Kingsbridge Road,
          Piscataway, New Jersey                                                                ~(10.7)
 10.6   Form of Lease - 40 Cragwood Road, South
             Plainfield, New Jersey                                                          ****(10.9)
 10.7   Lease 300A-B Corporate Court, South Plainfield, New Jersey                           +++(10.10)
 10.8   Stock Purchase Agreement dated March 5, 1987
             between the Company and Eastman Kodak Company                                   ****(10.7)
 10.9   Amendment dated June 19, 1989 to Stock Purchase
             Agreement between the Company and
             Eastman Kodak Company                                                            **(10.10)
10.10   Form of Stock Purchase Agreement between the Company
             and the purchasers of the Series A Cumulative
             Convertible Preferred Stock                                                       +(10.11)
10.11   Amendment to License Agreement and Revised License Agreement
             between the Company and RCT dated
             April 25, 1985                                                                  ++++(10.5)
10.12   Amendment dated as of May 3, 1989 to Revised License Agreement
             dated April 25, 1985 between the Company and Research
             Corporation                                                                      **(10.14)
10.13   License Agreement dated September 7, 1989 between the Company and
         Research Corporation Technologies, Inc.                                              **(10.15)
10.14   Master Lease Agreement and Purchase Leaseback Agreement dated
             October 28, 1994 between the Company and Comdisco, Inc.                          ##(10.16)
10.15   Amendment dated as of May 15, 1995 to Employment Agreement with
             Peter G. Tombros                                                                 ~~(10.17)
10.16   Stock Purchase Agreement dated as of June 30, 1995                                   ~~~(10.16)
10.17   Securities Purchase Agreement dated as of January 31, 1996                           ~~~(10.17)
10.18   Registration Rights Agreements dated as of January 31, 1996                          ~~~(10.18)
10.19   Warrants dated as of February 7, 1996 and issued pursuant to the Securities
             Purchase Agreement dated as of January 31, 1996                                 ~~~(10.19)

                                     - 11 -


10.20   Securities Purchase Agreement dated as of March 15, 1996                               ^(10.20)
10.21   Registration Rights Agreement dated as of March 15, 1996                               ^(10.21)
10.22   Warrant dated as of March 15, 1996 and issued pursuant to the Securities
        Purchase Agreement dated as of March 15, 1996                                          ^(10.22)
10.23   Amendment dated March 25, 1994 to License Agreement dated
         September 7, 1989 between the Company and Research Corporation
         Technologies, Inc.                                                                        o
10.24   Independent Directors' Stock Plan                                                          o
 27.0   Financial Data Schedule                                                                    o
 99.0   Factors to Consider in Connection with Forward-Looking Statements                      ^^(99.0)

</TABLE>

     o    Filed herewith.

     *    Previously filed as an exhibit to the Company's Registration Statement
          on Form S-2 (File No. 33- 34874) and incorporated  herein by reference
          thereto.

     **   Previously  filed as exhibits to the  Company's  Annual Report on Form
          10-K for the fiscal year ended June 30, 1989 and  incorporated  herein
          by reference thereto.

     ***  Previously filed as an exhibit to the Company's Registration Statement
          on Form  S-18  (File  No.  2-  88240-NY)  and  incorporated  herein by
          reference thereto.

     **** Previously filed as exhibits to the Company's  Registration  Statement
          on  Form  S-1  (File  No.  2-96279)  filed  with  the  Commission  and
          incorporated herein by reference thereto.

     +    Previously filed as an exhibit to the Company's Registration Statement
          on Form S-1  (File  No.  33-  39391)  filed  with the  Commission  and
          incorporated herein by reference thereto.

     ++   Previously  filed as an exhibit to the Company's Annual Report on Form
          10-K for the fiscal year ended June 30, 1992 and  incorporated  herein
          by reference thereto.

     +++  Previously  filed as an exhibit to the Company's Annual Report on Form
          10-K for the fiscal year ended June 30, 1993 and  incorporated  herein
          by reference thereto.

     ++++ Previously  filed as an exhibit to the Company's Annual Report on Form
          10-K for the fiscal year ended June 30, 1985 and  incorporated  herein
          by reference thereto.

     #    Previously filed as an exhibit to the Company's Current Report on Form
          8-K dated April 5, 1994 and incorporated herein by reference thereto.

     ##   Previously  filed as an exhibit to the Company's  Quarterly  Report on
          Form 10-Q for the quarter  ended  December  31, 1994 and  incorporated
          herein by reference thereto.

     ~    Previously  filed as an exhibit to the Company's  Quarterly  Report on
          Form 10-Q for the quarter ended March 31, 1995 and incorporated herein
          by reference thereto.

     ~~   Previously  filed as an exhibit to the Company's Annual Report on Form
          10-K for the fiscal year ended June 30, 1995 and  incorporated  herein
          by reference thereto.

     ~~~  Previously  filed as an exhibit to the Company's  Quarterly  Report on
          Form 10-Q for the quarter  ended  December  31, 1995 and  incorporated
          herein by reference thereto.

     ^    Previously  filed as an exhibit to the Company's  Quarterly  Report on
          Form 10-Q for the quarter ended March 31, 1996 and incorporated herein
          by reference thereto.

                                     - 12 -

<PAGE>

     ^^   Previously  filed as an exhibit to the Company's Annual Report on Form
          10-K for the fiscal year ended June 30, 1996 and  incorporated  herein
          by reference thereto.


     (b)  Reports on Form 8-K

           On December 20, 1996, the Company filed with the Commission a Current
      Report  on Form 8-K  dated  December  3, 1996  relating  to the  Company's
      announcement at the 1996 Annual Meeting of  Shareholders  that Green Cross
      Corporation,  a Japanese pharmaceutical company, is currently in Phase III
      clinical trials in Japan for recombinant Human Serum Albumin (rHSA). While
      the Company's  agreement with Green Cross Corporation  entitles Enzon to a
      customary  pharmaceutical  royalty  on  product  sales,  Green  Cross  has
      requested a reduction of the royalty.

           On November 4, 1996,  the Company filed with the Commission a Current
      Report on Form 8-K dated  September 27, 1996 relating to (i) its marketing
      agreement with Medac and (ii) its transfer of know-how for the manufacture
      of  PEG-Intron  A to Schering  and the  Company's  receipt of a $1 million
      payment.

                                     - 13 -

<PAGE>

                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.

                                                                     ENZON, INC.
                                                                    (Registrant)



Date: February 14, 1997   
                                                         By: /S/PETER G. TOMBROS
                                                            --------------------
                                                                Peter G. Tombros
                                                   President and Chief Executive
                                                                         Officer



                                                      By: /S/KENNETH J. ZUERBLIS
                                                             Kenneth J. Zuerblis
                                                     Vice President, Finance and
                                                         Chief Financial Officer


                                     - 14 -



                                                                 

                     AMENDMENT TO REVISED LICENSE AGREEMENT

         Under  this  Amendment,   effective  March  25,  1994  (the  "Amendment
Effective Date"), Research Corporation Technologies,  Inc., a Delaware nonprofit
corporation,  with offices at 101 N. Wilmot Road, Suite 600, Tucson,  AZ, ("RCT"
or  "LICENSOR"),  and Enzon,  Inc., a Delaware  corporation,  with offices at 40
Kingsbridge  Road,  Piscataway,  New Jersey,  ("Enzon" or  "LICENSEE")  agree as
follows:

                                    ARTICLE I
                                   BACKGROUND

         SECTION  1.1.  RCT  and  Enzon  are  parties  to that  certain  license
agreement made effective August 25, 1985, and subsequently amended (the "Revised
License  Agreement")  under which  Enzon was granted the right to make,  use and
sell certain  complexes  of  polyethylene  glycol  ("PEG") and  polypeptides  of
interest  under the  "PATENT  RIGHTS,"  as such term is defined  in the  Revised
License  Agreement,  and which PATENT  RIGHTS  include  United States Patent No.
4,179,337, issued December 18, 1979, (the "U.S. PEG Patent"). Enzon, the Eastman
Kodak Company  ("Kodak") and Sterling  Winthrop  Inc.,  formerly  Sterling Drug,
Inc., ("Sterling") are parties to that certain agreement made effective June 19,
1989 concerning the development of, inter alia,  complexes of PEG and superoxide
dismutase ("SOD") and the granting of a sublicense to Sterling under the Revised
License  Agreement to make,  use and sell PEG-SOD  (the  "Sterling  Agreement").
Under the Sterling  Agreement,  Enzon,  Kodak,  and Sterling have obligations to
cooperate with RCT in obtaining any patent extension of the U.S. PEG Patent that
may be obtained by RCT and that RCT may desire to obtain.

         SECTION 1.2. Section 156 of Title 35 of the United States Code entitles
RCT to seek  extension  of the term of a United  States  patent for one  product
covered by such patent.

         SECTION 1.3. Enzon desires that RCT agree to seek extension of the term
of the U.S.  PEG Patent,  to the extent such  extension  becomes  available  for
PEG-SOD  and that RCT  agree  not to seek any other  extension  of the U.S.  PEG
Patent based on any other drug product.
RCT is willing to so agree under the following terms and conditions.

         SECTION 1.4. RCT desires to confirm  Enzon's  continuing  obligation to
pay earned royalties during the term of any extension of the PATENT RIGHTS.

                                   ARTICLE II
                                    AMENDMENT

         SECTION  2.1.   Amendment  to  Article  7(a)  of  the  Revised  License
Agreement.  Article 7(a) of the Revise  license  Agreement is hereby  amended by
adding the following paragraph after the second paragraph of Article 7(a):


<PAGE>

                  This paragraph shall apply if the term of United States Patent
         4,179,337,  issued  December  18,  1979,  (the "U.S.  PEG  Patent")  is
         extended  beyond  December 18, 1996 pursuant to Section 156 of Title 35
         of the United  States Code and the rights  derived from such  extension
         apply  to  LICENSED  PRODUCTS  in  Field C (the  "PEG-SOD  Extension").
         LICENSEE and LICENSOR  agree and affirm that,  during the period of the
         PEG-SOD  Extension,  if any, the rights and duties of the parties under
         this License  Agreement,  and the terms of this License  Agreement,  as
         they  pertain to LICENSED  PRODUCTS  in Field C  ("PEG-SOD  Products"),
         shall continue in full force and effect  unchanged,  including  without
         limitation LICENSEE's obligations to pay royalties for the manufacture,
         USE or SALE of any PEG-SOD Product, throughout the term of the PEG- SOD
         Extension,  and the parties'  obligations  under  Articles 9 and 16(j).
         Nothing in any  agreement or this  Amendment  shall  affect,  change or
         diminish  LICENSEE's  or any  SUBLICENSEE's  obligation  to pay  earned
         royalties  to  LICENSOR  under  this  License   Agreement  through  the
         expiration of the PEG-SOD Extension,  or any party's  obligations under
         Articles 9 or 16(j).

         SECTION  2.2.  Amendment  to  Add  Article  17 to the  Revised  License
Agreement.  The  Revised  License  Agreement  is hereby  amended  by adding  the
following new Article 17 after Article 16:

         17.      The PEG-SOD Extension.

                  (a)  Obligations  of  LICENSOR.  Unless  LICENSOR and LICENSEE
         otherwise mutually agree, LICENSOR agrees to seek extension of the term
         of U.S.  PEG Patent,  to the extent such  extension is  available,  for
         PEG-SOD  and not to take any  action  or fail to take any  action  that
         would  preclude  or  delay  such  extension,   or  directly  place  the
         availability  of such extension in jeopardy.  So long as the law of the
         United  States  pertaining  to  extension of patents is  understood  or
         interpreted   to  permit  only  one  extension  per  patent  under  the
         provisions  of Section  156 of Title 35 of the United  States Code (and
         other corresponding sections of the law of the United States pertaining
         to patent extension),  LICENSOR agrees not to seek any extension of the
         term of the U.S. PEG Patent for any other  product  covered by the U.S.
         PEG  Patent  under the  provisions  of  Section  156 of Title 35 of the
         United States Code.  The  foregoing in no way  prohibits  LICENSOR from
         seeking  additional  extensions by way of legislative or judicial means
         and in no way prohibits  LICENSOR from seeking other  extensions  under
         Section 156 of Title 35 of the United States Code if such  provision is
         amended (or other provisions are added to the law of the United States)
         to provide for multiple  extensions or is interpreted in a final ruling
         by a court of competent jurisdiction (from which no appeal can be or is
         taken) to permit multiple extensions.

                  (b) Notice of PLA Filing  for FDA  Approval.  If, on or before
         December 18, 1996,  LICENSEE or any  SUBLICENSEE  files with the FDA an
         NDA or a Product  License  Application  ("PLA") seeking FDA Approval to
         market and sell a PEG-SOD Product, LICENSEE shall, immediately after it
         is aware of such filing, notify

                                      - 2 -

<PAGE>

         LICENSOR in writing of such filing.  If LICENSOR  becomes aware of such
         filing,  LICENSOR shall immediately  notify LICENSEE in writing of such
         filing.  If neither  LICENSEE nor LICENSOR has received  notice by June
         19, 1996 that the FDA has approved  such NDA or PLA, the parties  shall
         confirm that fact in writing  between  themselves,  the earliest  dated
         confirmation being hereafter referred to as the "Initiating Notice". If
         LICENSEE  or any  SUBLICENSEE  files with the FDA an NDA or PLA seeking
         FDA  approval to market and sell a PEG-SOD  Product and such NDA or PLA
         is approved by the FDA on or before December 18, 1996,  LICENSEE shall,
         immediately  after it is aware of such approval,  give LICENSOR written
         notice (the "Initiating Notice") of such approval.  If LICENSOR becomes
         aware  of such  approval,  LICENSOR  shall  immediately  give  LICENSEE
         written notice (the "Initiating Notice") of such approval.

                  (c) Responsibility for PEG-SOD Extension; Periodic Reports. In
         connection  with  filing for  interim  PEG-SOD  Extensions  (before FDA
         approval of the PEG-SOD Product) and the final PEG-SOD Extension (after
         such FDA  approval)  and any other  PEG-SOD  Extensions  as may  become
         available for any reason,  within ten days after LICENSOR's  receipt or
         issuance of any Initiating  Notice,  LICENSOR shall either:  (i) file a
         complete application with the United States Patent and Trademark Office
         ("USPTO") seeking the then-available PEG-SOD Extension; or (ii) subject
         to  Article  17(d)  below,  grant to  LICENSEE  the power of  attorney,
         substantially  in the form of  Exhibit A attached  hereto,  to seek the
         then-available PEG-SOD Extension (and all subsequent PEG-SOD Extensions
         available) on behalf of LICENSOR.  Concurrently  with the execution and
         delivery of such power of attorney,  LICENSOR shall execute and deliver
         to LICENSEE the Right of Assignee,  substantially  in the form attached
         to the power of  attorney  of Exhibit A. Every two weeks after the date
         of each such Initiating  Notice,  through the date on which the PEG-SOD
         Extension  corresponding  to such  Initiating  Notice  is  obtained  or
         finally denied,  the party undertaking to obtain the PEG- SOD Extension
         (the  "Responsible  Party")  shall report to the other party in writing
         regarding:  (A) the  status  of the  application;  (B) the  Responsible
         Party's  efforts to complete and file the  application  (including  the
         degree  of  cooperation  received  from  any  SUBLICENSEE,  if  such is
         necessary);  (C) any requests or inquiries  received  from the USPTO or
         the FDA,  and the  Responsible  Party's  responses  to such  request or
         inquiries;  and (D) if applicable,  the status of any administrative or
         judicial proceedings concerning the PEG-SOD Extension, its preparation,
         filing or  prosecution.  Although an extension  may be in effect at the
         time of a  particular  Initiating  Notice,  it is the  intention of the
         parties  that all actions  possible  are taken to maximize  and keep in
         effect any PEG-SOD Extension.

               (d) Best Effort Requirement.  The Responsible Party covenants and
          agrees to  exercise  its best  efforts to obtain  each such  extension
          until  each  PEG-SOD  Extension  is either  obtained  or it is finally
          denied by a court of competent  jurisdiction  from which no appeal can
          be taken. The other party shall fully and promptly  cooperate with the
          Responsible Party. "Best efforts" shall include,  without  limitation:
          (i) timely preparing

                                      - 3 -

<PAGE>

         and filing a complete application (subject to any delays that may arise
         because a SUBLICENSEE  does not  cooperate  with such  preparation  and
         filing but further subject to the Responsible  Party's obligation below
         to pursue legal  proceedings  to cause any such  SUBLICENSEE to provide
         such  information);  (ii) timely and fully responding to any request by
         the USPTO regarding the application;  (iii)  completely  exhausting any
         administrative  proceedings,  avenues or remedies that may be necessary
         to obtain such  extension;  (iv) timely  bringing  any suit,  appeal or
         other legal  proceeding in a court of competent  jurisdiction to obtain
         such  extension  or to  obtain  the  information  from any  SUBLICENSEE
         necessary to complete the application for the PEG-SOD  Extension and to
         cause such application to be timely filed; and (v) seeking extension by
         virtue of action by any legislative or judicial  authority.  If, in the
         reasonable opinion of the other party, the Responsible Party is failing
         to exercise its best efforts to obtain the PEG-SOD Extension, the other
         party may give the Responsible  Party five days' written notice of such
         opinion.  If the Responsible Party fails, in the reasonable  opinion of
         the other party,  to exercise its best efforts before the expiration of
         such five day period to obtain the PEG-SOD  Extension,  the other party
         may, in addition  to any other  remedies at law or equity,  enforce the
         requirements of this Article 17 through  injunctive  proceedings and an
         action at law or equity. Additionally,  if LICENSEE is the other party,
         LICENSEE may request the court to order  LICENSOR to grant LICENSEE the
         power of  attorney  to prepare  and file the  application  for any such
         PEG-SOD Extension;  if LICENSOR is the other party, LICENSOR may revoke
         the power of  attorney  granted to  LICENSEE  to prepare  and file such
         application  and may undertake to prepare and file such  application on
         LICENSOR's own behalf.  The party from whom  responsibility for seeking
         the PEG-SOD Extension is taken pursuant to the preceding sentence shall
         nonetheless  cooperate  with the  efforts of the other party in seeking
         each and every PEG- SOD Extension.

                  (e)  Grant of Power of  Attorney.  If:  (i)  LICENSOR  has not
         previously  granted  LICENSEE a power of  attorney  to seek any PEG-SOD
         Extension;  (ii)  a PLA or NDA  before  October  19,  1996;  and  (iii)
         LICENSEE has provided  LICENSOR with all  information in its possession
         that LICENSOR may desire for filing the interim  PEG-SOD  Extension but
         LICENSOR has not filed for interim PEG-SOD Extension before October 19,
         1996; then the power of attorney in the form attached to this Agreement
         as Exhibit B shall become  automatically  effective on October 19, 1996
         so as to enable LICENSEE to pursue the PEG-SOD Extension. The foregoing
         provisions  shall  apply with equal  force,  and to the same effect and
         extent,  for any subsequent  interim PEG-SOD  Extension except that the
         pertinent date on which such provision  takes effect for any subsequent
         interim  PEG-SOD  Extension  shall be the date  sixty  days  before the
         expiration of the  then-existing  interim  PEG-SOD  Extension.  If: (A)
         LICENSOR  has not  previously  granted  LICENSEE a power of attorney to
         seek any PEG-SOD  Extension;  (B) the FDA has approved an earlier-filed
         PLA or NDA  for a  PEG-SOD  Product;  and  (C)  LICENSEE  has  provided
         LICENSOR  with all  information  in its  possession  that  LICENSOR may
         desire for filing the final  PEG-SOD  Extension  but  LICENSOR  has not
         filed for final  PEG-SOD  Extension  on or before the later of the date
         twenty days after the date of such

                                      - 4 -

<PAGE>
         FDA  approval  or the date five days  after  LICENSOR's  receipt of the
         information  from  LICENSEE;  then the  power of  attorney  in the form
         attached  to the  Agreement  as  Exhibit B shall  become  automatically
         effective  on the 21st day after the date of such FDA approval so as to
         enable LICENSEE to pursue the PEG-SOD Extension.  Concurrently with the
         execution of this amendment to the Revised License Agreement,  LICENSOR
         shall   execute   and   deliver   to   LICENSEE   (or  its   designated
         representative)  the sole and  exclusive  power of attorney to seek any
         and all available PEG-SOD Extension, which power of attorney shall take
         the form of Exhibit B.  Concurrently with the execution and delivery of
         such power of attorney,  LICENSOR shall execute and deliver to LICENSEE
         the Right of Assignee,  substantially in the form attached to the power
         of attorney of Exhibit B. The  effectiveness and validity of such power
         of attorney shall be subject to, and contingent  upon, the satisfaction
         of the conditions specified in this Article 17(e)). LICENSEE shall hold
         such power of attorney in escrow until such time as the  conditions  of
         this  Article  17(e)  are,  in  the  reasonable  opinion  of  LICENSEE,
         satisfied,  at  which  time,  and  only at which  time,  such  power of
         attorney  shall be filed with the United  States  Patent and  Trademark
         Office. LICENSEE acknowledges and agrees that if it files such power of
         attorney  with the  USPTO at a time in which the  foregoing  conditions
         have not been fully satisfied,  such power of attorney shall be revoked
         ab initio and shall have no further force and effect. LICENSOR may seek
         any remedy at law or equity for LICENSEE's  violation of the provisions
         of this Article 17(e).

                  (f) No  Conflicting  Agreements.  Each  party  represents  and
         warrants to the other party that the  provisions  of this Article 17 do
         not violate,  and are not  inconsistent  with or contrary to, any other
         agreement, contract or understanding to which the representing party is
         presently  a party.  Each party  represents  and  warrants to the other
         party that the  representing  party shall not enter into any agreement,
         contract or understanding that would be violated by, inconsistent with,
         or  contrary  to,  the   representing   party's   fulfillment   of  the
         representing party's duties under this Article 17.

     SECTION  2.3.  Amendment  to  Article  1(e)(viii)  of the  Revised  License
Agreement. Article 1(e)(viii) of the Revised License Agreement is hereby changed
to read as follows:

         (viii)   "LICENSED  FIELD" shall mean Fields A, B, C, D, E, F, G, H and
                  I  taken  collectively,  and,  from  and  after  the  date  of
                  extension  of the  license  granted in ARTICLE 2 hereof to any
                  NEW FIELD,  as defined  in clause  (x) of this  ARTICLE  1(e),
                  shall  also  include  each such NEW FIELD so added,  but in no
                  event shall the LICENSED FIELD include the EXCLUDED FIELD.

         SECTION  2.4.   Amendment  to  Article  1(e)  of  the  Revised  License
Agreement.  Article 1(e) often Revised  License  Agreement is hereby  amended by
adding the following subparagraph (xi) after subparagraph (x) of Article 1(e):


                                      - 5 -

<PAGE>

         (xi)     "Field  I"  shall  mean  the  making,  Using  and  Selling  of
                  PEG-polypeptide complexes, the polypeptide portion of which is
                  the       enzyme        glucocerebrosidase,        hereinafter
                  "PEG-Glucocerebrosidase."

         SECTION 2.5. Amendment to Article 6 of the Revised Licensed  Agreement.
Article 6 of the  Revised  License  Agreement  is hereby  amended  by adding the
following Paragraph (e) to the end of Article 6:

               (e)  Notwithstanding  the  foregoing,  no License  Issue Fee,  no
          Annual License  Maintenance Fee and no Annual Minimum Royalty shall be
          due or payable by LICENSEE for Field I.

         SECTION 2.6  Continued  Effect.  The Revised  License  Agreement  shall
continue in force and effect unchanged, except as specifically set forth in this
document.


         IN WITNESS  WHEREOF,  the parties  have each  caused a duly  authorized
officer to sign this Amendment  Agreement on the date(s)  indicated below, to be
effective the Amendment Effective Date.


ENZON, INC.                                          RESEARCH CORPORATION
                                                     TECHNOLOGIES, INC.



By:/S/ABRAHAM ABUCHOWSKI                    By:/S/GARY M. MUNSINGER
- ------------------------                    -----------------------
Title:                                      President

Date:March 24, 1994                         Date:March 24, 1994

                                      - 6 -





   

                                   ENZON, INC.
                      1996 INDEPENDENT DIRECTORS STOCK PLAN
                                                                        

     1.  Purpose  and  Persons  Covered.  The  purpose  of the 1996  Independent
Directors  Stock Plan of Enzon,  Inc. is to provide  compensation to Independent
Directors  for  serving on the Board and align  their  economic  interests  more
closely with those of Enzon shareholders.

     2. Definitions.

          (a) "Board" shall mean the Board of Directors of the Company.

          (b) "Common  Stock"  shall mean the $.01 par value Common Stock of the
     Company.

          (c) "Company" shall mean Enzon Inc., a Delaware corporation.

          (d) "Compensation  Committee" shall mean the Compensation Committee of
     the Board.

          (e) "Fair  Market  Value" of a Share of Common Stock as of a specified
     date shall mean (i) the last  reported  sale price of a Share on the NASDAQ
     National  Market on such date or if no Shares are traded on such date, such
     last  reported sale price on the next  following  date on which such Shares
     are  traded,  or  (ii)  the  closing  price  of a  Share  on the  principal
     securities  exchange  on which such Shares are traded on such date or if no
     Shares are traded on such date,  such closing  price on the next  following
     date on which such Shares are traded, or (iii) if the Shares are not traded
     on the NASDAQ National Market or on a securities  exchange,  the average of
     the high bid and low  asked  prices of the  Shares in the  over-the-counter
     market on such date or if no such  prices are  recorded  on such date,  the
     next  following  date on which  such  high  bid and low  asked  prices  are
     recorded. If the Shares are not publicly traded, Fair Market Value shall be
     determined in good faith by the Board.

          (f)  "Independent  Directors"  shall mean members of the Board who are
     not officers and/or employees of the Company.

          (g) "Plan"  shall mean this Enzon,  Inc.  1996  Independent  Directors
     Stock Plan.

          (h) "Share" shall mean one share of Common Stock.


<PAGE>

     3. Administrator. The Plan shall be administered, construed and interpreted
by the Compensation Committee or the Board.

     4.  Eligibility.  All Independent  Directors shall participate in the Plan.
Independent  Directors  shall cease to be eligible to participate in the Plan at
the time their membership on the Board of Directors terminates.

     5. Effective Date.  This Plan was approved by the Board  effective  January
15, 1996 (the "Effective  Date");  provided that the Plan shall terminate if the
shareholders of the Company do not approve the Plan on or before March 31, 1997.
The right to receive  Shares in accordance  with the Plan shall be earned by the
Independent  Directors  commencing  as of the Effective  Date;  provided that no
Shares shall be issued to the Independent  Directors hereunder until the Plan is
approved by the  shareholders  of the  Company;  and further  provided  that the
Independent  Directors'  right to the Shares earned hereunder shall terminate if
the Plan is not approved by the  shareholders  of the Company on or before March
31, 1997.

     6. Grant of Shares

          (a)  Quarterly  Grants.  As part of his or her  director's  fee,  each
     Independent  Director  shall be  granted  Shares  equivalent  to $2,500 per
     quarter,  as determined in subsection (b) hereof, plus Shares equivalent to
     $500  per  Board  meeting  attended  by the  Independent  Director  in such
     quarter,  as  determined  in  subsection  (b) hereof.  Subject to Section 5
     hereof,  Shares  granted shall be issued and  delivered to the  Independent
     Director as soon as is  practicable  following the last trading day of each
     quarter provided such Independent  Director has served  continuously on the
     Board during the preceding quarter.

          (b)  Determining   Grant.  The  number  of  Shares  issuable  will  be
     determined by dividing the amount of compensation payable to an Independent
     Director in each quarter by the Fair Market Value of a Share (as defined in
     Section 2 (e)  hereof) on the last day of such  quarter.  A whole  Share of
     Common Stock shall be paid in lieu of any fractional  Share  resulting from
     the computation described in this section.

     7. Shares.  The Shares granted under the Plan shall be Shares of authorized
but unissued or reacquired  Common Stock.  The aggregate  number of Shares which
may be issued under this Plan shall not exceed 240,000, subject to adjustment in
accordance with Section 10 hereof.

                                      - 2 -

<PAGE>

     The  limitations  established  by  this  Section  7  shall  be  subject  to
adjustment  upon  the  occurrence  of the  events  specified  and in the  manner
provided in Section 10 hereof.

     8. Terms and Conditions of Shares.

          (a) Rights as a Stockholder. No adjustment shall be made for dividends
     (ordinary or extraordinary,  whether in cash, securities or other property)
     or  distributions or other rights for which the record date is prior to the
     date the Shares are  granted  hereunder,  except as  provided in Section 10
     hereof.  No rights as a stockholder  of the Company as such shall accrue to
     any person hereunder unless and until Shares are granted.

     9. Term of Plan. Shares may be granted pursuant to the Plan until 5:00 p.m.
local time on December 3, 1999.

     10.  Recapitalization.  In the event of a  recapitalization,  stock  split,
stock dividend, combination or exchange of Shares, merger, consolidation, rights
offering,  reorganization  or  liquidation  or any other  similar  change in the
corporate structure of the Company or the Shares, the Compensation  Committee or
the Board may make such equitable adjustments to prevent dilution or enlargement
of rights in the number and class of Shares  authorized to be granted  hereunder
as the Compensation Committee or the Board may deem appropriate.

     11. Securities Law Requirements. No Shares shall be issued unless and until
the  Company  has  determined  that:  (i) it has taken all  actions  required to
register  the Shares  under the  Securities  Act of 1933 or perfect an exemption
from  the  registration   requirements  thereof;  (ii)  any  applicable  listing
requirement of the NASDAQ  National Market or of any stock exchange on which the
Common Stock is then listed has been satisfied;  and (iii) any other  applicable
provision of state or Federal law has been satisfied.

     12.  Termination  or  Amendment  of the  Plan.  The  Board  may at any time
terminate the Plan and may from time to time alter or amend the Plan or any part
thereof;  provided  that, any such  alteration or amendment  shall be subject to
shareholder  approval to the extent required by applicable Federal or state law,
or the  NASDAQ  National  Market or such  other  automated  quotation  system or
national exchange on which the Common Stock may be traded.

     13. No Obligation to Reelect. Nothing in the Plan shall be deemed to create
any obligation on the part of the Board of Directors to nominate any Independent
Director for reelection by the Company's stockholders.

                                      - 3 -

<PAGE>

     14.  Governing  Law.  The  provisions  of this Plan shall be  governed  and
construed  in  accordance  with  the  internal  laws of the  State  of  Delaware
applicable to agreements  made and to be performed  entirely  within such state,
without regard to the conflicts of laws provisions thereof.


                                      - 4 -


<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
This schedule contains summary financial  information  extracted from the Enzon,
Inc. and Subsidiaries  Consolidated  Condensed  Balance Sheet as of December 31,
1996 and the  Consolidated  Condensed  Statement of Operations for the three and
six months ended December 31, 1996 and is qualified in its entirety by reference
to such financial statements.
</LEGEND>
       
<S>                             <C>                             <C>
<PERIOD-TYPE>                                   3-MOS              6-MOS
<FISCAL-YEAR-END>                        JUN-30-1996             JUN-30-1996
<PERIOD-END>                             DEC-31-1996             DEC-31-1996
<CASH>                                   $10,351,505              $10,351,505
<SECURITIES>                                      0                         0                    
<RECEIVABLES>                             3,376,915                 3,376,915
<ALLOWANCES>                                      0                         0  
<INVENTORY>                                 820,441                   820,441  
<CURRENT-ASSETS>                         14,885,784                14,885,784  
<PP&E>                                   16,220,391                16,220,391  
<DEPRECIATION>                           12,404,047                12,404,047  
<TOTAL-ASSETS>                           20,499,199                20,499,199  
<CURRENT-LIABILITIES>                     6,778,565                 6,778,565  
<BONDS>                                           0                         0  
                             0                         0  
                                   1,447                     1,447  
<COMMON>                                    290,100                   290,100  
<OTHER-SE>                               11,323,322                11,323,322  
<TOTAL-LIABILITY-AND-EQUITY>             20,499,199                20,499,199  
<SALES>                                   3,553,975                 6,274,566
<TOTAL-REVENUES>                          3,558,985                 7,373,875
<CGS>                                       994,325                 1,980,314
<TOTAL-COSTS>                             4,427,933                 9,119,760                                       
<OTHER-EXPENSES>                                  0                         0  
<LOSS-PROVISION>                                  0                         0  
<INTEREST-EXPENSE>                            4,847                    11,600  
<INCOME-PRETAX>                           (710,845)               (1,429,459)  
<INCOME-TAX>                                      0                         0  
<INCOME-CONTINUING>                       (710,845)               (1,429,459)  
<DISCONTINUED>                                    0                         0  
<EXTRAORDINARY>                                   0                         0  
<CHANGES>                                         0                         0  
<NET-INCOME>                              (710,845)               (1,429,459)  
<EPS-PRIMARY>                                (0.03)                    (0.05)  
<EPS-DILUTED>                                    0                          0 
                                                                               
                                                                               
                          

</TABLE>


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