FILE NO. 333-46117
                                                FILED PURSUANT TO RULE 424(b)(3)



                                   Enzon, Inc.

                                SUPPLEMENT NO. 2
                      TO PROSPECTUS DATED FEBRUARY 13, 1998
           RELATING TO 150,000 SHARES OF COMMON STOCK, $.01 PAR VALUE

     The Prospectus is  supplemented  by eliminating  name "The Pyne  Companies"
from the section "Selling  Stockholders--Stock  Ownership" and replacing it with
the name "White Bay (Wyoming), Inc."



                   The Date of this Supplement is June 4, 1999



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