ENZON INC
DEF 14A, 2000-10-27
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION

                Proxy Statement Pursuant to Section 14(a) of the
               Securities Exchange Act of 1934 (Amendment No. __ )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material pursuant to Rule 14a-11(c) or Rule 14a-12

                                   ENZON, INC.
                (Name of Registrant as Specified In Its Charter)

                             KEVIN T. COLLINS, ESQ.
                   (Name of Person(s) filing Proxy Statement)

Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.

[ ]  $500 per each party to the controversy pursuant to Exchange Act Rule
     14a-6(I)(3).

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(I)(4) and 0-11.

     (1)  Title of each class of securities to which transaction applies:

          ----------------------------------------------------------------------

     (2)  Aggregate number of securities to which transaction applies:

          ----------------------------------------------------------------------

     (3)  Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11: Set forth the amount on which the
          filing fee is calculated and state how it was determined.

          ----------------------------------------------------------------------

     (4)  Proposed maximum aggregate value of transaction:

          ----------------------------------------------------------------------

     (5)  Total fee paid.

          ----------------------------------------------------------------------

[ ]  Check box if any part of the fee is offset as provided by Exchange Act rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     1)   Amount Previously Paid:

          ------------------------

     2)   Form, Schedule or Registration Statement No.:

          ------------------------

     3)   Filing Party:

          ------------------------

     4)   Date Filed:

          ------------------------



<PAGE>

                               [LOGO] ENZON, INC.

                               20 Kingsbridge Road
                          Piscataway, New Jersey 08854
                                 (732) 980-4500

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD DECEMBER 5, 2000

To our Stockholders:

     You are hereby  notified  that the  annual  meeting  of  stockholders  (the
"Annual  Meeting")  of Enzon,  Inc.,  a  Delaware  corporation  ("Enzon"  or the
"Company")  will be held at the Embassy  Suites Hotel,  121  Centennial  Avenue,
Piscataway,  New Jersey on Tuesday,  December 5, 2000 at 10:00 a.m.  local time,
for the following purposes:

     1.   To elect two  Class II  directors,  each for a term of three  years in
          accordance with the Company's Certificate of Incorporation and By-Laws
          (Proposal No. 1);

     2.   To vote  on a  proposal  to  approve  an  amendment  to the  Company's
          Non-Qualified Stock Option Plan, as amended,  (the "Plan") which would
          add certain vesting  acceleration  provisions upon a change of control
          of the  Company  (as  defined  therein)  for future  option  grants to
          officers,  employees  directors and independent  consultants under the
          Plan (Proposal No. 2);

     3.   To ratify the  selection  of KPMG LLP,  independent  certified  public
          accountants,  to audit the  consolidated  financial  statements of the
          Company for the fiscal year ending June 30, 2001 (Proposal No. 3); and

     4.   To transact  such other matters as may properly come before the Annual
          Meeting or any adjournment thereof.

     Only holders of record of the Company's  Common  Stock,  par value $.01 per
share, and Series A Cumulative  Convertible  Preferred Stock, par value $.01 per
share,  at the close of business on October 25, 2000 are  entitled to notice of,
and to vote at the Annual Meeting.

     We hope that as many  stockholders as possible will  personally  attend the
Annual Meeting. Whether or not you plan to attend the Annual Meeting, your proxy
vote  is  important.  To  assure  your  representation  at the  meeting,  please
complete,  sign and date the  enclosed  proxy card and return it promptly in the
enclosed  envelope.  Sending in your proxy will not  prevent  you from voting in
person at the Annual Meeting.

                                        By order of the Board of Directors,



                                        Kenneth J. Zuerblis, Corporate Secretary

Piscataway, New Jersey
October 27, 2000


<PAGE>

                                   ENZON, INC.

                                     -------

                                 PROXY STATEMENT

                                     -------

     This Proxy Statement is furnished to stockholders of record of Enzon,  Inc.
("Enzon"  or the  "Company")  as of October 25,  2000,  in  connection  with the
solicitation  of proxies  for use at the annual  meeting  of  stockholders  (the
"Annual Meeting") to be held on Tuesday, December 5, 2000 and at any adjournment
thereof.  The  accompanying  proxy is solicited by the Board of Directors of the
Company and is revocable  by the  stockholder  any time before it is voted.  For
more information concerning the procedure for revoking the proxy, see "General."
This Proxy Statement was first mailed to stockholders of the Company on or about
November 5, 2000, accompanied by the Company's Annual Report to Stockholders for
the fiscal year ended June 30,  2000.  The  principal  executive  offices of the
Company  are  located at 20  Kingsbridge  Road,  Piscataway,  New Jersey  08854,
telephone (732) 980-4500.

                      OUTSTANDING SHARES AND VOTING RIGHTS

     Only holders of the Company's  common stock,  par value $.01 per share (the
"Common Stock" or "Common Shares") and Series A Cumulative Convertible Preferred
Stock,  $.01 per share (the  "Series A  Preferred  Stock" or "Series A Preferred
Shares")  outstanding  at the close of business on October 25, 2000 (the "Record
Date") are entitled to receive notice of and vote at the Annual  Meeting.  As of
the Record Date, the number and class of stock that was  outstanding and will be
entitled to vote at the meeting were 41,422,554 Common Shares and 7,000 Series A
Preferred Shares.  Each Common Share and Series A Preferred Share is entitled to
one vote on all matters.  No other class of securities  will be entitled to vote
at the Annual Meeting. There are no cumulative voting rights.

     To be elected,  a director  must  receive a  plurality  of the votes of the
Common Shares and Series A Preferred Shares,  voting as a single class,  present
in person or  represented by proxy at the Annual Meeting and entitled to vote on
the election of directors.  The  affirmative  vote of at least a majority of the
Common Shares and Series A Preferred Shares, present in person or represented by
proxy at the Annual Meeting and entitled to vote thereon,  voting  together as a
single class,  is necessary for approval of Proposal No. 2 and Proposal No. 3. A
quorum is representation in person or by proxy at the Annual Meeting of at least
one-third  of  the  combined  Common  Shares  and  Series  A  Preferred   Shares
outstanding as of the Record Date.

     Pursuant to the Delaware  General  Corporation Law, only votes cast "For" a
matter  constitute  affirmative  votes.  Proxy  cards which are voted by marking
"Withheld" or "Abstain" on a particular matter are counted as present for quorum
purposes and for purposes of determining  the outcome of such matter,  but since
they are not cast "For" a particular  matter,  they will have the same effect as
negative  votes or votes  cast  "Against"  a  particular  matter.  If a  validly
executed proxy card is not marked to indicate a vote on a particular  matter and
the proxy granted  thereby is not revoked  before it is voted,  it will be voted
"For" such matter.  Where brokers are prohibited from  exercising  discretionary
authority  for  beneficial  owners  who have not  provided  voting  instructions
(commonly  referred to as "broker  non-votes"),  such broker  non-votes  will be
treated as shares that are present for purposes of determining the presence of a
quorum; however, with respect to proposals which require the affirmative vote of
a percentage of shares present at the Annual  Meeting for approval,  such broker
non-votes will be treated as not present for purposes of determining the outcome
of any such matter. With respect to proposals which require the affirmative vote
of a  percentage  of the  outstanding  shares for  approval,  since such  broker
non-votes are not cast "For" a particular matter, they will have the same effect
as negative votes or votes cast "Against" such proposals.

                                       1

<PAGE>

                     PROPOSAL NO. 1 - ELECTION OF DIRECTORS

     Pursuant to the provisions of the Company's  Certificate  of  Incorporation
and By-laws,  the Board of Directors is comprised of three classes of directors,
designated  Class I, Class II and Class III.  One class of  directors is elected
each year to hold  office for a  three-year  term and until  successors  of such
directors are duly elected and qualified. Two Class II directors will be elected
at this  year's  Annual  Meeting.  The  nominees  for  election to the office of
director,  and certain  information  with respect to their  backgrounds  and the
backgrounds of non-nominee  directors,  are set forth below. It is the intention
of  the  persons  named  in  the  accompanying   proxy  card,  unless  otherwise
instructed,  to vote to elect the nominees  named herein as Class II  directors.
Each of the nominees named herein presently serves as a director of the Company.
In the event any of the nominees  named herein is unable to serve as a director,
discretionary  authority  is  reserved to the Board of  Directors  to vote for a
substitute.  The Board of  Directors  has no reason to  believe  that any of the
nominees named herein will be unable to serve if elected.

                 Nominees for Election to the Office of Director
                           at the 2000 Annual Meeting

                                          Director
Nominee                           Age     Since     Position with the Company
-------                           ---     -----     -------------------------

Randy H. Thurman(1)(2)            51      1993      Chairman of the Board

Dr. David W. Golde(4)(5)          60      1998      Director


                    Non-Nominee Directors Continuing to Serve
             in the Office of Director After the 2000 Annual Meeting

                                          Director
Nominee                           Age     Since     Position with the Company
-------                           ---     -----     -------------------------

Peter G. Tombros (1) (6)          58      1994      President and
                                                       Chief Executive Officer

David S. Barlow (2)(4)(7)         43      1999      Director

Dr. Rosina B. Dixon (2)(4)(5)(6)  58      1994      Director

Rolf A. Classon(2)(3)(7)          55      1997      Director

Robert LeBuhn (1)(3)(5)(7)        68      1994      Director


A.M. "Don" MacKinnon, age 75, a director of the Company since 1990, has resigned
from the Board effective December 4, 2000 and will not stand for re-election.

(1)  Member of the Executive Committee
(2)  Member of the Compensation Committee
(3)  Member of the Finance and Audit Committee
(4)  Member of Scientific Advisory Committee
(5)  Member of Corporate Governance Committee
(6)  Class I director serving until the 2002 Annual Meeting
(7)  Class III director serving until the 2001 Annual Meeting

                                       2

<PAGE>

                        BUSINESS EXPERIENCE OF DIRECTORS

Nominee Class II Directors for Election at the 2000 Annual Meeting

     Randy H.  Thurman  has served as the  Chairman  of the Board of the Company
since April 1996 and as a Director of the Company since April 1993.  Mr. Thurman
is Chairman and Chief Executive Officer of Strategic Reserves, LLC, a company he
founded in 1996.  Mr.  Thurman is the founder and has been Chairman of the Board
of Health Care Strategies 2000, a global healthcare consulting firm, since 1995.
During 1996,  Mr.  Thurman also served as a director of Spencer Stuart Inc. From
1993 to 1995,  Mr.  Thurman  served as Chairman and Chief  Executive  Officer of
Corning  Life  Sciences.  From 1985 to 1993,  Mr.  Thurman  served as  Corporate
Executive  Vice  President  and a Director  of  Rhone-Poulenc  Rorer,  Inc.  and
President of  Rhone-Poulenc  Rorer  Pharmaceuticals,  Inc. He also serves on the
Board of Directors of Closure Medical, Inc and Curagen Corporation.

     Dr.  David W. Golde has served as a Director  of the  Company  since  March
1998.  Dr.  Golde has been the  Physician-In-Chief  at Memorial  Sloan-Kettering
Cancer  Center  since 1996.  From 1991 to 1996,  Dr. Golde served as Head of the
Division of Hematology and Oncology at Memorial  Sloan-Kettering  Cancer Center.
Prior to 1991,  Dr.  Golde was a professor of medicine and Chief of the Division
of  Hematology  and  Oncology  at UCLA,  Director  of the UCLA AIDS  Center  and
Director of the UCLA Clinical Research Center. Dr. Golde currently serves on the
Board of  Directors of Cypress  Biosciences,  Inc. and on the Board of Overseers
and Managers of Memorial Sloan-Kettering Cancer Center.

     The Board of Directors  recommends a vote FOR Mr.  Thurman and Dr. Golde as
Class II Directors (Proposal No. 1 on the Proxy Card).

Non-Nominee Class III Directors Serving Until the 2001 Annual Meeting

     David S. Barlow has served as a Director  of the  Company  since June 1999.
Mr. Barlow is currently President of Black Diamond Capital, a private investment
company. From 1995 to September 1999 Mr. Barlow was President of Pharmaceuticals
at Sepracor,  Inc. From 1993 to 1995 Mr. Barlow served as the General Manager of
Pharmaceuticals  at Sepracor,  Inc. Prior to 1993 Mr. Barlow held several senior
level positions at Rhone-Poulenc  Rorer, Inc.,  including Vice President,  World
Wide Marketing and Business  Development  at Armour  Pharmaceutical  Company,  a
subsidiary of Rhone-Poulenc Rorer, Inc. He also serves on the Board of Directors
of  Pan  Pacific  Pharmaceuticals,   Inc.,  Biostream,  Inc.,  Lotus  Biomedical
Corporation,  Red Bird LLC and  Hemasure,  Inc. Mr. Barlow serves as Chairman of
the Pan Pacific Pharmaceuticals and Biostream Board of Directors.

     Rolf A. Classon has served as a Director of the Company since January 1997.
Since  1995 Mr.  Classon  has served as an  Executive  Vice  President  of Bayer
Corporation and President of Bayer  Diagnostics.  From 1991 to 1995, Mr. Classon
was an  Executive  Vice  President  in  charge of Bayer  Diagnostics'  Worldwide
Marketing,  Sales and Service  operations.  From 1990 to 1991,  Mr.  Classon was
President and Chief  Operating  Officer of Pharmacia  Biosystems  A.B.  Prior to
1991, Mr. Classon served as President of Pharmacia  Development Company Inc. and
Pharmacia A.B. Hospital Products Division.

     Robert  LeBuhn has served as a Director of the Company  since  August 1994.
Mr. LeBuhn is a private investor and is a Director of Cambrex Corporation and US
Airways  Group,  Inc.  He is Trustee and  President  of the  Geraldine  R. Dodge
Foundation,  a  Trustee  and  Treasurer  of All Kinds of  Minds,  a  Trustee  of
Executive Service Corp.,  director of The International  Research Foundation for
Children's Eyecare, Inc. and a member of the National Council of the Aspen Music
Festival and School.

Non-Nominee Class I Directors Serving until the 2002 Annual Meeting

     Peter G. Tombros has served as President and Chief Executive Officer of the
Company and a Director of the Company since April 1994.  Prior to joining Enzon,
Mr. Tombros spent 25 years with Pfizer Inc., a research based, global healthcare
company  headquartered in New York City. From 1986 to March 1994, he served as a
Vice

                                       3

<PAGE>

President of Pfizer Inc. in the following  areas:  Executive  Vice  President of
Pfizer Pharmaceuticals,  a division of Pfizer Inc., corporate strategic planning
and investor  relations.  From 1980 to 1986,  Mr.  Tombros served as Senior Vice
President of Pfizer  Pharmaceuticals and general manager for the Roerig division
of Pfizer Inc. Mr. Tombros  currently  serves on the Board of Trustees of Cancer
Care and the National Cancer Care Foundation and Dominican College.  He has been
a Director of the American Foundation of Pharmaceutical Education since 1980 and
served as Chairman for three of those years.  Mr. Tombros serves on the Board of
Directors of NPS Pharmaceuticals Inc. and Alpharma Inc.

     Dr.  Rosina B. Dixon has served as a Director of the Company  since  August
1994. Dr. Dixon has been a consultant to the pharmaceutical industry since 1987.
Prior to such time she held senior  positions at Ciba-Geigy  Pharmaceuticals,  a
division  of  Ciba-Geigy  Corporation,   and  Schering-Plough  Corporation.  She
received her M.D. from Columbia  University,  College of Physicians and Surgeons
and is  certified by the National  Board of Medical  Examiners  and the American
Board of Internal Medicine.  She is a member of the American College of Clinical
Pharmacology,  American  Society for Clinical  Pharmacology and Therapeutics and
the  National  Association  of Corporate  Directors  and  currently  serves as a
Director of Church & Dwight Co., Inc. and Cambrex Corporation.

                             DIRECTORS' COMPENSATION

Directors' Cash Compensation

     During the  fiscal  year ended June 30,  2000,  the  Company  paid Randy H.
Thurman $106,250 in consideration  for serving as Chairman of the Board.  During
such fiscal year,  the Company did not pay cash  compensation  to its  remaining
directors  for acting as directors or as members of  committees  of the Board of
Directors,  other than  reimbursement  of  reasonable  expenses  incurred by the
directors in attending board and committee meetings.

Directors' Stock Options

     In December  1993,  the Board of Directors  adopted,  and the  stockholders
approved,  an amendment to the Non-Qualified Stock Option Plan, as amended, (the
"Plan") providing for automatic grants of options  ("Automatic  Grants") under a
formula  (the  "Formula")  to  non-executive  members of the Board of  Directors
("Independent  Directors").  This  formula was amended by the Board of Directors
and approved by the stockholders in 1999.

     Under the Formula, each of the Independent Directors automatically receives
an option to purchase  10,000  shares of Common  Stock yearly on January 2 which
vests one year after the grant (the "Regular  Grant").  Newly elected  directors
receive  an option to  purchase  10,000  shares of Common  Stock  (the  "Initial
Election Grant") on the date of each Independent  Director's initial election to
the Board. In addition,  each newly-elected  Independent Director  automatically
receives an option to purchase such Independent Director's pro rata share of the
Regular  Grant for the year in which such  Independent  Director  was  initially
elected to the Board,  which equals the product of 833  multiplied by the number
of whole months  remaining  in the year until the next  Regular  Grant (the "Pro
Rata Grant"). Those options granted pursuant to a Pro Rata Grant vest and become
exercisable on the January 1st following  such  Independent  Director's  initial
election to the Board.  Those options  granted  pursuant to an Initial  Election
Grant vest and become  exercisable as to 5,000 shares one year after the date of
grant;  and as to 5,000 shares two years after the date of grant.  The per share
exercise price of options  granted  pursuant to the Formula is equal to the fair
market value of the Common Stock on the date of grant.

     An option granted to an Independent  Director  pursuant to the Formula will
not  become  exercisable  as to the  relevant  shares  unless  such  Independent
Director has served  continuously  on the Board during the period  commencing on
the date the  option  was  granted  and  terminating  on the date the  option is
scheduled to vest; provided,  however,  that if an Independent Director does not
fulfill such continuous service  requirement due to such Independent  Director's
death or  disability  all  options  granted  under the  Formula and held by such
Independent  Director  nonetheless  vest and become  exercisable  as though such
Independent  Director  fulfilled the continuous

                                       4

<PAGE>

service  requirement.  An option granted to an Independent  Director pursuant to
the  Formula  remains  exercisable  for a period of ten  years  from the date of
grant.

Independent Directors' Stock Plan

     The Company's  1996  Independent  Directors'  Stock Plan (the  "Independent
Directors' Stock Plan") provides  compensation to Independent  Directors serving
on the Board which is paid in the form of the Company's Common Stock. Other than
the Chairman of the Board and as described below,  Independent Directors are not
currently  entitled  to  receive  cash   compensation.   Under  the  Independent
Directors' Stock Plan, each Independent  Director is entitled to compensation in
the form of shares of Common  Stock of the Company  with a value equal to $2,500
per quarter and $500 for each meeting attended by such Independent Director. The
number of shares issued will be based on the last reported sale price of a share
of Common  Stock on the Nasdaq  National  Market at the end of the  quarter  for
which  fees are  payable.  During  the year ended  June 30,  2000,  the  Company
recorded an aggregate of $92,500 in Independent  Directors'  fees. The following
is a  summary  of  compensation  paid to the  Independent  Directors  under  the
Independent Director's Stock Plan:

                                          Value of         Number
                                        Consideration     of Shares
                                        -------------     ---------
         Randy H. Thurman                  $13,600           361
         David S. Barlow                    13,900           370
         Rolf A. Classon                    12,100           320
         Dr. Rosina B. Dixon                13,600           361
         David W. Golde                     12,600           335
         Robert LeBuhn                      13,600           361
         A.M. "Don" MacKinnon               13,100           348

     On October 20, 2000, the  Compensation  Committee of the Board of Directors
amended the  Independent  Directors'  Stock Plan to provide that the Independent
Directors  will be  entitled  to elect to receive up to 50% of the fees  payable
under the Independent  Directors'  Stock Plan in cash, with the remainder of the
fees to be paid in Common Stock in the manner described above.

Section 16(a) Beneficial Ownership Reporting Compliance

     Ownership of and transactions in the Company's stock by executive  officers
and  directors  of the  Company  and  owners  of 10% or  more  of the  Company's
outstanding  Common  Stock are  required to be reported  to the  Securities  and
Exchange  Commission pursuant to Section 16(a) of the Securities Exchange Act of
1934,  as  amended.  During the year ended June 30, 2000 all such  reports  were
filed in a timely manner.

Directors' Stock Ownership Program

     On October 20, 2000, the Board of Directors  implemented a director's stock
ownership  program which  requires  each of the  Directors to own  beneficially,
outstanding Common Stock of the Company with a market value of at least $100,000
within  two  years  after  the  Director  first  joins  the  Company's  Board of
Directors.  The  determination  of whether the shares  owned  beneficially  by a
Director meets the $100,000  minimum market value  requirement  will be based on
the highest  average  trading price of the Common Stock over any  consecutive 20
trading  days  during the two year  period  after the  director  first joins the
Company's  Board of  Directors  or the price  paid for the  Common  Stock by the
Director.  Shares of Common  Stock  underlying  outstanding  options will not be
counted  towards  satisfaction  of this  requirement.  The Board may waive  this
requirement under certain circumstances.  All of the Company's current directors
meet this requirement.

                                       5

<PAGE>

               INFORMATION CONCERNING BOARD AND COMMITTEE MEETINGS
                           AND COMMITTEES OF THE BOARD

     Seven  meetings of the  Company's  Board of Directors  were held during the
fiscal year ended June 30, 2000. Each incumbent  director  attended at least 75%
of the total number of meetings of the Board of Directors. With the exception of
Rolf A. Classon and David W. Golde,  all incumbent  directors  attended at least
75% of the total number of meetings of any committees of the Board of Directors,
of which such director was a member, held during the fiscal year.

     As of June 30, 2000,  the standing  committees  of the  Company's  Board of
Directors  were  the  Finance  and  Audit  Committee,   Compensation  Committee,
Executive  Committee,  Scientific  Advisory  Committee and Corporate  Governance
Committee.

     As of June 30,  2000,  the Finance and Audit  Committee  was  comprised  of
Robert LeBuhn,  Chairman, Rolf A. Classon and A.M. "Don" MacKinnon.  The primary
purpose of the Finance and Audit  Committee is to assist the Board in fulfilling
its responsibility to oversee  management's  conduct of the Company's  financial
reporting  process,  including by  overviewing  the financial  reports and other
financial  information provided by the Company to any governmental or regulatory
body,  the public or other  users  thereof,  the  Company's  systems of internal
accounting and financial controls, the annual independent audit of the Company's
financial  statements and the Company's legal  compliance and ethics programs as
established by management and the Board. The Finance and Audit Committee adopted
a written charter during fiscal 2000, a copy of which is attached as Appendix A.
The Finance and Audit Committee held three meetings during the fiscal year ended
June 30, 2000.

     As of June 30, 2000,  the  Compensation  Committee was comprised of Rolf A.
Classon,  Chairman,  Dr. Rosina B. Dixon,  David S. Barlow and Randy H. Thurman.
The primary  functions  of the  Compensation  Committee  are to  administer  the
Company's  Non-Qualified  Stock Option Plan,  determine the  compensation of the
Company's officers and senior management and review compensation  policy.  There
were six  meetings of the  Compensation  Committee  during the fiscal year ended
June 30, 2000.

     The Executive Committee, which as of June 30, 2000, was comprised of Robert
LeBuhn,  Chairman,  Peter G. Tombros and Randy H. Thurman,  was  established  to
review and make decisions  concerning  matters which would otherwise come before
the Board,  as permitted by Delaware  General  Corporate  Law and the  Company's
By-laws.  Given the  relatively  small size of the  Company's  current  Board of
Directors, the Company determined that efficiencies were not being realized from
meetings of the Executive  Committee and therefore suspended regular meetings of
the  Executive  Committee  in  September  1994.  There were no  meetings  of the
Executive Committee during the fiscal year ended June 30, 2000.

     The  Scientific  Advisory  Committee  is  comprised  of Dr. David W. Golde,
Chairman,  Dr.  Rosina B. Dixon and David S.  Barlow.  This  committee  provides
scientific  input to the Board and serves as the liaison  between the  Company's
senior  research  and  development  management  and the  Board.  There  were two
meetings of the Scientific  Advisory Committee during the fiscal year ended June
30, 2000.

     The  Corporate  Governance  Committee is comprised of Dr.  Rosina B. Dixon,
Chairperson,  Dr. David W. Golde and Robert LeBuhn.  This committee  reviews and
sets corporate governance policy and will be responsible for director and senior
management  succession  planning.  There  were four  meetings  of the  Corporate
Governance Committee during the fiscal year ended June 30, 2000. The Company has
not yet  established a policy with respect to the  consideration  of stockholder
nominees to the Board of Directors.

                      COMPENSATION COMMITTEE INTERLOCKS AND
                              INSIDER PARTICIPATION

     During the fiscal  year ended June 30,  2000,  the  members of the Board of
Directors  serving on the Compensation  Committee of the Board of Directors were
Rolf A. Classon,  Chairman,  Dr. Rosina B. Dixon, David S. Barlow, Robert LeBuhn
and Randy H. Thurman, all of whom are non-employee directors of the Company.

                                       6

<PAGE>

                           AUDIT AND FINANCE COMMITTEE

     During the fiscal  year ended June 30,  2000,  the  members of the Board of
Directors  serving on the Finance and Audit  Committee of the Board of Directors
were Robert LeBuhn,  Rolf A. Classon and A.M. "Don"  MacKinnon,  all of whom are
considered  "independent  directors"  as  defined  by Rule  4200 (a) (15) of the
National Association of Securities Dealers listing standards.

                    BUSINESS EXPERIENCE OF EXECUTIVE OFFICERS

     Set forth below is certain  information  regarding the executive officer of
the Company who does not serve on the Board of Directors.

     Kenneth  J.  Zuerblis,  41,  has served as Chief  Financial  Officer  since
January 1996 and as Vice  President,  Finance since April 1994.  During May 2000
Mr.  Zuerblis was  appointed  Secretary of the Company.  From July 1991 to April
1994, Mr. Zuerblis served as the Company's Controller. From January 1982 to July
1991,  Mr.  Zuerblis  was  employed by KPMG LLP.  He became a  certified  public
accountant in 1985.



                                       7

<PAGE>

                           SUMMARY COMPENSATION TABLE

     The following  table  provides a summary of cash and non-cash  compensation
for each of the last three fiscal years ended June 30, 2000,  1999 and 1998 with
respect  to the  Company's  Chief  Executive  Officer  and the  other  executive
officers  serving  during  the  fiscal  year  ended  June 30,  2000 (the  "Named
Executive Officers").

<TABLE>
<CAPTION>
                                                                                                  Long-Term
                                                                                                Compensation
                                                   Annual Compensation                             Awards
                                                  ---------------------                     ---------------------
       Name and                                                              Other Annual   Securities Underlying    All Other
   Principal Position                    Year     Salary($)    Bonus($)   Compensation($)(1)     Options(#)       Compensation($)(2)
   ------------------                    ----     ---------    --------   ------------------     ----------       ------------------
<S>                                      <C>       <C>         <C>              <C>              <C>                  <C>
Peter G. Tombros                         2000      $348,834    $112,000         $ --                --  (3)           $  7,622
President and Chief                      1999       336,000     120,000           --              43,000(4)              6,152
  Executive Officer                      1998       336,000      70,560           --              78,000(5)              5,000

John A. Caruso(6)                        2000       177,500      44,800           --                --  (3)              6,331
Vice President, Administration,          1999       175,364      54,000           --              17,300(4)              1,639
  General Counsel and                    1998       171,642      26,025           --              90,000(5)               --
  Corporate Secretary

Kenneth J. Zuerblis                      2000       194,077      65,700           --                --  (3)              7,622
Vice President, Finance,                 1999       165,119      60,000           --              17,000(4)              4,803
  Chief Financial Officer and            1998       154,692      33,600           --             110,000(5)              3,775
  Corporate Secretary
</TABLE>

(1)  Excludes  perquisites and other personal  benefits that in the aggregate do
     not exceed 10% of the Named  Executive  Officer's  total annual  salary and
     bonus.

(2)  Consists of annual Company contributions to a 401(k) plan.

(3)  Messrs. Tombros, Caruso and Zuerblis did not receive any options as part of
     their bonus for the year ended June 30, 2000.  The  Compensation  Committee
     did grant Mr. Tombros and Mr.  Zuerblis long term incentive  options during
     July 2000 in lieu of options under the bonus plan.  Mr. Tombros was granted
     an option to purchase  100,000  shares of the Company's  Common Stock at an
     exercise  price of $50.625 per share on August 10, 2000, as part of his new
     employment  agreement.  The  option  granted to Mr.  Tombros  will vest and
     become  exercisable  on June  30,  2003,  the  last  day of his  employment
     agreement,  if Mr.  Tombros is still  employed by the Company on such date.
     The vesting and  exercisability  of the options  granted will accelerate in
     the event the closing price of the Company's  Common Stock exceeds $100 per
     share for at least  twenty  consecutive  trading  days as  reported  by the
     Nasdaq  National  Market during a time when Mr.  Tombros is employed by the
     Company.  In the event of a change in control of the Company (as defined in
     Mr. Tombros' employment agreement),  other than a liquidation, a sale of at
     least 80% of the assets of the Company, or a merger in which the Company is
     not the  surviving  entity,  the option  will vest and  become  exercisable
     according  to the terms of the  employment  agreement  as if the  change in
     control  had not  occurred.  However,  if a change in  control in which the
     Company  liquidates,  sells at least  80% of its  assets,  or  merges  with
     another Company and is not the surviving corporation,  occurs prior to July
     1, 2003, and the Company's  shareholders receive at least $100 per share in
     connection with the change in control, the option will vest upon the change
     in control if Mr.  Tombros is still  employed  by the Company on such date,
     or, in the event that Mr.  Tombros is not still  employed by the Company on
     such date, if Mr. Tombros' termination was not voluntary, was for cause, or
     was due to Mr.  Tombros' death or disability.  The  Compensation  Committee
     also granted to Mr.  Zuerblis an option to purchase  100,000  shares of the
     Company's Common Stock at an exercise price of $44.75 per share.  50,000 of
     the shares  underlying this option will vest and become  exercisable over a
     five year period at a rate of 10,000 shares per year. The remaining  50,000
     shares will vest and become  exercisable on the seventh  anniversary of the
     date of grant, if Mr. Zuerblis is employed by the Company on such date. The
     vesting and  exercisability  of such shares will  accelerate if the closing
     stock price of the  Company's  Common  Stock  exceeds $100 per share for at
     least twenty  consecutive  trading days as reported by the Nasdaq  National
     Market during a time in which Mr.  Zuerblis is employed by the Company.  In
     the  event of a  change  in  control  of the  Company  (as  defined  in Mr.
     Zuerblis' option agreement),  other than a liquidation,  a sale of at least
     80% of the assets of the  Company,  or a merger in which the Company is not
     the surviving entity, the option will vest and become exercisable according
     to the terms of the option  agreement  as if the change in control  had not
     occurred.  However,  with  respect to the 50,000  shares  which vest on the
     seventh  anniversary of the date of grant,  if a change in control in which
     the Company  liquidates,  sells at least 80% of its assets,  or merges iwth
     another Company, occurs prior to July 31, 2007,

                                       8

<PAGE>

     and  the  Company's  shareholders  receive  at  least  $100  per  share  in
     connection with the change in control, the option will vest upon the change
     in control if Mr.  Zuerblis is still  employed by the Company on such date,
     or, in the event that Mr.  Zuerblis is not still employed by the Company on
     such date, if Mr. Zuerblis' termination was not voluntary or was for cause.
     With  respect  to the  shares  which  vest  over a five year  period,  if a
     liquidation, a sale of at least 80% of the Company's assets, or a merger in
     which the Company is not the  surviving  entity,  occurs  prior to July 31,
     2005,  the options will vest upon the change in control if Mr.  Zuerblis is
     still  employed  by the  Company  on such  date,  or, in the event that Mr.
     Zuerblis  is not  still  employed  by the  Company  on  such  date,  if Mr.
     Zuerblis' termination was not voluntary or was for cause.


(4)  Represents  stock  options  granted  during  July 1999,  which  represent a
     portion of the Named  Executive  Officer's  total bonus earned for the year
     ended June 30, 1999.

(5)  Includes stock options granted during July 1998,  which represent a portion
     of the Named Executive Officer's total bonus earned for the year ended June
     30, 1998.

(6)  During May 2000 Mr. Caruso resigned as an executive  officer of the Company
     and in August 2000 Mr. Caruso became a part-time employee of the Company.


                                       9

<PAGE>

                        OPTION GRANTS IN LAST FISCAL YEAR

     The following  table  contains  information  concerning  the grant of stock
options  under  the  Company's  Non-Qualified  Stock  Option  Plan to the  Named
Executive Officers during the fiscal year ended June 30, 2000.

<TABLE>
<CAPTION>
                                               Individual Grants
                        ---------------------------------------------------------------
                        Number of                                                             Potential Realizable Value at Assumed
                        Securities       % of Total                                               Annual Rates of Stock Price
                        Underlying     Options Granted                                          Appreciation for Option Term (3)
                          Options        to Employees     Exercise or Base    Expiration     --------------------------------------
      Name              Granted (1)     in Fiscal Year     Price ($/Share)       Date        0%($)         5%($)            10%($)
      ----              -----------     --------------     ---------------       ----        -----         -----            ------
<S>                      <C>                <C>                <C>              <C>            <C>      <C>              <C>
Peter G. Tombros         43,000(2)          18.50%             $ 22.31          7/20/09        0        $  603,385       $1,529,086
John A. Caruso           17,300(2)           7.44%               22.31          7/20/09        0           242,757          615,155
Kenneth J. Zuerblis      17,000(2)           7.31%               22.31          7/20/09        0           238,548          604,526
</TABLE>

(1)  All options were granted at an exercise  price that equaled or exceeded the
     fair market value of the Common Stock on the date of grant,  as  determined
     by the last sale price as reported on the Nasdaq National Market.

(2)  These options were granted during July 1999 as part of the Named  Executive
     Officer's  total  bonus  earned  for the year ended  June 30,  1999.  These
     options will vest and become exercisable as to 25% of the underlying shares
     in each  year,  beginning  on July 21,  2000 and  ending on July 21,  2004,
     provided  the option  holder is employed by the Company as of the  relevant
     vesting date.  The options will become  exercisable as to all shares if the
     option  holder's  employment  by the Company is  terminated  under  certain
     circumstances  following a "change in control" of the Company as defined in
     certain  agreements  between  each of Messrs.  Tombros and Zuerblis and the
     Company. See "Employment and Termination Agreements."

(3)  The amounts set forth in the three  columns  represent  hypothetical  gains
     that might be  achieved  by the  optionees  if the  respective  options are
     exercised at the end of their terms. These gains are based on assumed rates
     of stock price appreciation of 0%, 5% and 10% compounded  annually from the
     dates the respective  options were granted.  The 0% appreciation  column is
     included  because the options  were  granted  with  exercise  prices  which
     equaled or exceeded the market price of the underlying  Common Stock on the
     date of grant, and thus will have no value unless the Company's stock price
     increases above the exercise prices.


                                       10

<PAGE>

                   OPTION EXERCISES AND FISCAL YEAR-END VALUES

     The following  table sets forth the  information  with respect to the Named
Executive  Officers  concerning  the exercise of options  during the fiscal year
ended June 30, 2000 and unexercised options held as of June 30, 2000.

<TABLE>
<CAPTION>
                                                                    Number of Securities                Value of Unexercised
                                                                   Underlying Unexercised               In-the-Money Options
                                                                    Options at FY-End(#)                   at FY-End ($)(1)
                          Shares Acquired          Value       ------------------------------      -------------------------------
  Name                    On Exercise (#)       Realized($)    Exercisable      Unexercisable      Exercisable       Unexercisable
  ----                    ---------------       -----------    -----------      -------------      -----------       -------------

<S>                             <C>                <C>          <C>                <C>             <C>                 <C>
Peter G. Tombros                 --                $ --         1,108,000          82,000          $43,280,658         $2,272,063

John A. Caruso                   --                  --           220,392          42,300            8,521,569          1,249,244

Kenneth J. Zuerblis              --                  --           210,000          52,000            7,888,750          1,603,188
</TABLE>

(1)  Based upon a market value of $42.50 as determined by the last sale price as
     reported on the Nasdaq  National  Market on June 30, 2000.  If the exercise
     price is equal to or  greater  than  such last sale  price,  the  option is
     deemed to have no value.

                      EMPLOYMENT AND TERMINATION AGREEMENTS

     The  Company  has an  employment  agreement  with Peter G.  Tombros,  which
terminates on June 30, 2003, pursuant to which he receives an annual base salary
of $367,500.  In the event Mr. Tombros'  employment is terminated for any reason
prior to the second anniversary of this agreement,  except if such employment is
terminated  (i)  voluntarily  by Mr.  Tombros  other  than  in  response  to the
Company's  prior material  breach of the  employment  agreement or the Company's
employment of a successor to Mr. Tombros as Chief Executive Officer, (ii) by the
Company  for "cause" (as  defined in the  employment  agreement),  or (iii) as a
result of Mr.  Tombros'  death or  disability,  Mr.  Tombros will be entitled to
receive  the  greater of either the  remainder  of his base  salary  through the
second  anniversary  of the agreement or his base salary for one year after such
termination. If Mr. Tombros' employment is terminated for any reason, except for
the  reasons set forth in (i),  (ii) or (iii)  above,  subsequent  to the second
anniversary  date of the agreement,  Mr. Tombros is entitled to receive his base
salary for one year following such termination or until he is employed on a full
time  basis,  whichever  is  sooner.  In the event Mr.  Tombros'  employment  is
terminated due to his death or disability,  his base salary will be paid for six
months subsequent to such termination. Pursuant to his employment agreement, Mr.
Tombros was granted an option  under the  Company's  Non-Qualified  Stock Option
Plan to purchase  100,000  shares of the  Company's  Common Stock at a per share
exercise price of $50.625,  the fair market value of the Company's  Common Stock
on the date of grant. The options vest and become  exercisable on June 30, 2003,
if Mr. Tombros is still employed by the Company as President and Chief Executive
Officer on such date. The vesting and exercisability of the options granted will
accelerate  in the event the  Company's  Common Stock  exceeds $100 for at least
twenty consecutive trading days as reported by the Nasdaq National Market during
a time in which Mr. Tombros is employed by the Company. In the event of a change
in control of the  Company (as defined in Mr.  Tombros'  employment  agreement),
other than a  liquidation,  a sale of at least 80% of the assets of the Company,
or a merger in which the Company is not the  surviving  entity,  the option will
vest and become exercisable  according to the terms of the employment  agreement
as if the change in control had not occurred. However, if a change of control in
which the Company  liquidates,  sells at least 80% of its assets, or merges with
another company and is not the surviving  corporation,  occurs prior to July 1,
2003,  and the  Company's  shareholders  receive  at  least  $100  per  share in
connection  with the change in control,  the option will vest upon the change in
control if Mr.  Tombros is still  employed by the  Company on such date,  if Mr.
Tombros'  termination  was  not  voluntary,  was  for  cause,  or was due to Mr.
Tombros' death or disability.  Mr. Tombros'  employment  agreement also requires
him to maintain the confidentiality of Company information and assign inventions
to the Company.  Mr. Tombros is precluded from competing with the Company during
the term of his  employment  agreement and for two years after his employment is
terminated if his  employment is terminated by the Company for "cause" or by Mr.
Tombros  voluntarily  (except in response to the Company's prior material breach
of the  employment  agreement or the Company's  employment of a successor to Mr.
Tombros as Chief Executive Officer).

     The  Company  has  agreements  with each of its  executive  officers  which
provide for payment to each executive officer of three years of compensation and
benefits  (as defined in such  agreements)  following a change in

                                       11

<PAGE>

control of the Company (as defined in such agreements),  including the provision
for such  payment  in the event such  executive  officer's  employment  with the
Company is terminated  under  certain  circumstances.  Following  such change in
control any  unvested  options  held by the  executive  officers  would vest and
become  exercisable if the executive  officer's  employment  with the Company is
terminated  under certain  circumstances  following such change in control.  Any
vested options held by the executive  officer would vest and become  exercisable
if the  executive  officer's  employment  with the Company is  terminated  under
certain  circumstances  following  such  change  in  control.  The term of these
agreements is for three years. Prior to a change in control of the Company,  the
agreements  automatically renew on each successive anniversary for an additional
three years, unless the Company gives the executive officer 60 days notice prior
to the anniversary date that it does not plan to renew such contracts.




                                       12

<PAGE>

         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS


     During the fiscal year ended June 30, 2000, the  Compensation  Committee of
the  Board  of  Directors   consisted  of  four  non-employee   directors.   The
Compensation  Committee  determines  all  compensation  paid or  awarded  to the
Company's  executive  officers,  including the Named  Executive  Officers in the
Summary Compensation Table. As with many other biotechnology companies,  Enzon's
current level of development  and the highly  volatile  nature of  biotechnology
stocks in general makes executive compensation based on sales and earnings goals
or stock performance impracticable.  The Compensation Committee believes that an
important factor in Enzon's success is the continued development and maintenance
of a culture focused on team-oriented performance. In this context, compensation
has  been  based  on the  accomplishment  of a  blend  of  mutually  shared  and
individual  goals.  The  Compensation   Committee  has  reviewed  the  executive
compensation  of  other  biotechnology   companies  with  comparable  levels  of
stockholders'  equity and  development  and has  designed  the  Company's  total
executive  compensation  to be targeted at the median of executive  compensation
levels of these companies.  The compensation of the Company's executive officers
consist of three  principal  components:  (i) base salary and  benefits,  (ii) a
bonus based on individual  contributions  evaluated  against  annual goals,  and
(iii) long-term incentives in the form of stock option grants.

The  Compensation  Committee  has  established  a formal  Performance  Incentive
Program for its executive officers and other members of senior  management.  The
structure  and  design  of  the  program  was  based  on  a  detailed  study  of
compensation programs provided at comparable biotechnology companies.  Under the
program Mr.  Tombros can earn a cash bonus of up to a maximum of 40% of his base
salary.  Mr. Tombros is also entitled to receive stock option grants to purchase
Common Stock under the bonus plan. During August 2000 the Compensation Committee
granted  Mr.  Tombros,  as part of a new  employment  agreement,  an  option  to
purchase  100,000  shares of Common  Stock at an  exercise  price of $50.625 per
share. These options vest and become exercisable on June 30, 2003 if Mr. Tombros
is still employed at the Company.  The vesting and exercisability of the options
will  accelerate in the event the closing  stock price of the  Company's  Common
Stock  exceeds  $100 per share for at least twenty  consecutive  trading days as
reported by the Nasdaq  National  Market  during a time in which Mr.  Tombros is
employed by the Company. The other executive officer,  Mr. Zuerblis,  can earn a
cash bonus of up to a maximum of 35% of his base salary and stock option  grants
to purchase Common Stock.  Mr. Caruso,  who resigned as an executive  officer of
the  Company  in May 2000,  was also  eligible  to earn a cash  bonus of up to a
maximum of 35% of his base salary.  The amount of bonus paid and options granted
under the program is based upon the achievement of  predetermined  corporate and
individual  objectives.  In lieu of a stock  option  grant as a bonus  under the
program,  the  Compensation  Committee  granted Mr. Zuerblis  100,000 options to
purchase the  Company's  Common Stock at an exercise  price of $44.75 per share.
50,000 of the shares  underlying  the options  will vest and become  exercisable
over a five year  period  at a rate of 10,000  shares  per year.  The  remaining
50,000  shares  will vest on the  seventh  anniversary  of the grant date if Mr.
Zuerblis is still  employed at the Company.  The vesting and  exercisability  of
such shares will  accelerate if the closing stock price of the Company's  Common
Stock  exceeds  $100 per share for at least twenty  consecutive  trading days as
reported by the Nasdaq  National  Market during a time in which Mr.  Zuerblis is
employed by the  Company.  No such options  were  granted to Mr.  Caruso.  Stock
options  granted under the program are granted with exercise prices equal to the
fair market value of the Company's Common Stock on the date of grant.

     The  annual  salary of  $350,000  and the bonus  awarded  to the  Company's
President  and Chief  Executive  Officer for the fiscal year ended June 30, 2000
were based on Mr. Tombros' extensive prior experience as a senior executive of a
major  multinational  pharmaceutical  firm  and the  compensation  paid to chief
executive officers with similar credentials at comparable biotech companies. The
bonus paid to Mr. Tombros under the Company's  Performance Incentive Program was
based on many factors  including  increasing the awareness of the Company in the
financial community,  the strengthening of the Company's financial position,  as
well as the  progress  made by the Company  and its  partners on products in the
Company's development pipeline.

                                       13

<PAGE>

     During the fiscal  year ended June 30,  2000,  the  Compensation  Committee
awarded cash bonuses under the program  described  above to the Company's  other
executive officers,  Messrs. Caruso and Zuerblis.  The bonuses were based on the
executives'  contributions  to  increase  the  awareness  of the  Company in the
financial community and the improvement of the Company's financial position. Mr.
Caruso's  cash bonus was prorated for the period during the fiscal year in which
he served as an executive officer of the Company.

     The Compensation  Committee also adjusted the salary level of Mr. Zuerblis.
The salary adjustment was based on a detailed  compensation  study of executives
with similar credentials at comparable biotechnology companies.

                                                      THE COMPENSATION COMMITTEE
                                                      Rolf A. Classon, Chairman
                                                      David S. Barlow
                                                      Dr. Rosina B. Dixon
                                                      Randy H. Thurman

                                       14

<PAGE>

                  REPORT OF THE FINANCE AND AUDIT COMMITTEE OF
                             THE BOARD OF DIRECTORS

     The Company's  Finance and Audit  Committee  consists of three  independent
members of the Board of Directors as defined in Rule 4200(a)(15) of the National
Association  of  Securities  Dealers'  listing  standards.  The Board  adopted a
written  charter  for the Audit  Committee  on June 7, 2000,  a copy of which is
attached as Appendix A to this Proxy Statement.

     The primary  purpose of the Finance  and Audit  Committee  is to assist the
Board in fulfilling its  responsibility to oversee  management's  conduct of the
Company's  financial  reporting  process,  including  overviewing  the financial
reports  and  other  financial  information  provided  by  the  Company  to  any
governmental  or  regulatory  body,  the  public  or other  users  thereof,  the
Company's  systems of internal  accounting  and financial  controls,  the annual
independent audit of the Company's financial  statements and the Company's legal
compliance and ethics programs as established by management and the Board.

     The Finance and Audit  Committee  has  reviewed and  discussed  the audited
financial  statements  for the fiscal year ended June 30, 2000 with  management.
Furthermore,  the Finance and Audit  Committee has discussed  with the Company's
independent auditors,  KPMG LLP, the matters required to be discussed by SAS 61.
Also, the Finance and Audit  Committee has received the written  disclosures and
letter from KPMG required by Independence Standards Board Standard No. 1 and has
discussed with KPMG such auditing  firm's  independence.  Based on these reviews
and  discussions the Finance and Audit  Committee  recommended  that the audited
financial statements be included in the Company's Annual Report on Form 10-K for
the fiscal year ended June 30, 2000, the last fiscal year for filing such annual
report with the U.S. Securities and Exchange Commission.




                                              THE FINANCE AND AUDIT COMMITTEE
                                              Robert LeBuhn
                                              Rolf A. Classon
                                              A.M. "Don" MacKinnon



                                       15

<PAGE>

                      STOCKHOLDER RETURN PERFORMANCE GRAPH

     The graph below summarizes the total cumulative  return  experienced by the
Company's stockholders from June 30, 1995 through June 30, 2000, compared to the
Nasdaq National  Market-US Index and the Company's Peer Group index,  the Nasdaq
Biotechnology  Index.  The changes for the periods  shown in the graph and table
below are based on the  assumption  that $100 had been invested in the Company's
Common Stock and in each index below on June 30, 1995.


                 COMPARISON OF FIVE YEAR CUMULATIVE TOTAL RETURN
       AMONG ENZON, INC., THE NASDAQ NATIONAL MARKET INDEX AND PEER GROUPS

                                                Cumulative Total Return
                             ---------------------------------------------------
                               6/95     6/96     6/97     6/98     6/99     6/00
ENZON, INC                   100.00   147.37    94.74   268.42   871.05  1789.47
NASDAQ STOCK MARKET (U.S.)   100.00   128.39   156.14   205.58   296.03   437.27
NASDAQ BIOTECHNOLOGY         100.00   146.02   153.22   157.18   251.34   602.91





                                       16

<PAGE>

                          SECURITY OWNERSHIP OF CERTAIN
                        BENEFICIAL OWNERS AND MANAGEMENT

     The following  table sets forth certain  information as of October 25, 2000
concerning  stock  ownership  of  all  persons  known  by  the  Company  to  own
beneficially 5% or more of the outstanding shares of the Company's voting stock,
each director,  each executive officer named in the Summary  Compensation  Table
and all executive officers and directors of the Company as a group:

                                                                   Percentage of
Directors, Officers or                           Number of         Voting Stock
  5% Stockholders(1)                             Shares(2)        Outstanding(3)
  ------------------                             ---------        --------------

Peter G. Tombros                                1,188,050 (4)          2.8%
Randy H. Thurman                                  116,318 (5)            *
Rolf A. Classon                                    66,599 (6)            *
David S. Barlow                                    25,416 (7)            *
Dr. Rosina B. Dixon                               144,297 (8)            *
Dr. David W. Golde                                 87,562 (9)            *
Robert LeBuhn                                     128,275(10)            *
A.M. "Don" MacKinnon                               98,905(11)            *
Kenneth J. Zuerblis                               172,450(12)            *
Janus Capital Corporation                       2,564,220(13)          5.8%
 100 Fillmore Street
 Denver, Colorado  80206
All Executive Officers and Directors            2,029,478(14)          4.7%
as a group (ten persons)

--------------

* Less than one percent.

(1)  The address of all current executive officers and directors listed above is
     in the care of the Company.

(2)  All shares  listed are Common  Stock.  Except as discussed  below,  none of
     these  shares are  subject to rights to acquire  beneficial  ownership,  as
     specified in Rule 13d-3(d)(1) under the Securities Exchange Act of 1934, as
     amended,  and the beneficial  owner has sole voting and  investment  power,
     subject to community property laws where applicable.

(3)  Gives  effect to  41,422,554  shares of  Common  Stock and 7,000  shares of
     Series A Preferred  Stock which were issued and  outstanding  as of October
     25,  2000.  Generally,  the Series A Preferred  Stock and Common Stock will
     vote as one class of stock.  Each  share of Common  Stock and each share of
     Series A Preferred  Stock is entitled to one vote. The percentage of voting
     stock  outstanding  for each  stockholder is calculated by dividing (i) the
     number of shares of Common  Stock  deemed to be  beneficially  held by such
     stockholder  as of  October  25,  2000 by (ii) the sum of (A) the number of
     shares of Common  Stock  outstanding  as of October  25,  2000 plus (B) the
     number of shares of Series A Preferred Stock  outstanding as of October 25,
     2000 plus (C) the number of shares of Common Stock  issuable  upon exercise
     of options held by such  stockholder  which were  exercisable as of October
     25, 2000 or which will become  exercisable within 60 days after October 25,
     2000.

(4)  Includes  1,157,750  shares subject to options which were exercisable as of
     October  25,  2000 or which will  become  exercisable  within 60 days after
     October 25, 2000.

(5)  Includes  100,000  shares  subject to options which were  exercisable as of
     October  25,  2000 or which will

                                       17

<PAGE>


     become exercisable within 60 days after October 25, 2000.

(6)  Includes  60,000  shares  subject to options which were  exercisable  as of
     October  25,  2000 or which will  become  exercisable  within 60 days after
     October 25, 2000.

(7)  Includes  14,996  shares  subject to options which were  exercisable  as of
     October  25,  2000 or which will  become  exercisable  within 60 days after
     October 25, 2000.

(8)  Includes  116,664  shares  subject to options which were  exercisable as of
     October  25,  2000 or which will  become  exercisable  within 60 days after
     October 25,  2000,  500 shares held by Dr.  Dixon's  husband and 100 shares
     held by Dr.  Dixon's son. Dr. Dixon  disclaims  beneficial  ownership as to
     shares held by her husband and son.

(9)  Includes  48,320  shares  subject to options which were  exercisable  as of
     October  25,  2000 or which will  become  exercisable  within 60 days after
     October 25, 2000,  32,500 shares held by a retirement trust for Dr. Golde's
     benefit, 2,600 shares held by a separate trust for Dr. Golde's daughter and
     1,000 shares beneficially owned by Dr. Golde's wife.

(10) Includes  106,664  shares  subject to options which were  exercisable as of
     October  25,  2000 or which will  become  exercisable  within 60 days after
     October 25, 2000.

(11) Includes  62,313 shares held by trusts of which Mr.  MacKinnon is a trustee
     and  36,550  shares  held by  trusts of which  his wife is a  trustee.  Mr.
     MacKinnon disclaims beneficial ownership as to 16,800 of the above shares.

(12) Includes  169,250  shares  subject to options which were  exercisable as of
     October  25,  2000 or which will  become  exercisable  within 60 days after
     October 25, 2000 and 600 shares owned by Mr. Zuerblis' IRA.

(13) The  information  concerning  the  stock  ownership  of the  Janus  Capital
     Corporation  was obtained  from a Schedule  13F filed by the Janus  Capital
     Corporation  with the  Securities  and Exchange  Commission  for the period
     ended June 30, 2000.

(14) Includes all shares  owned  beneficially  by the  directors  and  executive
     officers named in the Summary Compensation Table.

                                       18

<PAGE>


                     PROPOSAL NO. 2 -- APPROVAL OF AMENDMENT
                     TO THE NON-QUALIFIED STOCK OPTION PLAN

     In  November   1987,   the  Company's   Board  of  Directors   adopted  the
Non-Qualified  Stock  Option Plan (the "Plan") in order to enable the Company to
attract and retain qualified employees,  directors and independent  consultants.
Subject  to  stockholder  approval,  the  Board of  Directors  has  approved  an
amendment  to the Plan to provide  for  acceleration  of  vesting,  for  options
granted  after the  amendment is approved by the  stockholders  upon a change in
control of the Company.

     The  Board  believes  that the best way to  attract  and  retain  qualified
executives  and board members is to offer  significant  potential  rewards based
upon the  Company's  success  through  the  issuance  of stock  options.  Of the
7,900,000 shares of Common Stock currently  authorized for options granted under
the Plan, at October 20, 2000,  1,490,263  shares remained  available for future
grants.

     The following summary  description of the Plan is qualified in its entirety
by the full text of the Plan which may be obtained by the Company's stockholders
upon request to the Secretary of the Company.

     The last sale price of a share of the Company's Common Stock as reported by
the Nasdaq National Market on October 20, 1999 was $71.00.

Basic Terms

     Under the Plan,  directors,  officers  and  employees  of the  Company  and
independent  consultants  to the Company  have been,  and will be,  eligible for
grants of options to  purchase  shares of Common  Stock.  To date,  all  options
granted under the Plan to directors, employees and consultants have been awarded
at the  discretion  of the Board of Directors or the  Compensation  Committee or
pursuant to a pre-established formula.  Currently, except for options granted to
Independent  Directors,  the Compensation Committee or of the Board of Directors
determines  who will  receive  options  under the Plan,  the number of shares of
Common Stock which will be issuable  upon  exercise of options which are granted
under the Plan and the terms of the options granted under the Plan to the extent
the terms are not otherwise set forth in the Plan. Currently,  no option granted
under the Plan may be transferred by the optionee, otherwise than by will or the
laws of descent and  distribution  or to certain family members of the optionee,
as  determined by the  Compensation  Committee in its  discretion.  The exercise
price of the  options  must be at least  equal to the fair  market  value of the
underlying  Common  Stock  as of the  date of  grant.  Either  the  Compensation
Committee  or the Board of  Directors  may, in its  discretion,  provide that an
option  may not be  exercised  in whole or in part for any  specified  period or
periods of time. No option may be exercised prior to six months from the date of
grant, except immediately prior to the dissolution or liquidation of the Company
or a merger or consolidation where the Company is not the surviving corporation,
in which case all outstanding  options become immediately  exercisable.  Options
expire no later than the tenth anniversary of the date of grant. For information
concerning  the options  granted to  Independent  Directors  under the Plan, see
"Directors Compensation -- Directors Stock Options."

Acceleration upon Change in Control

     Presently,  if the Company is the  surviving  corporation  in any merger or
consolidation,  any option shall pertain,  apply and relate to the securities to
which a holder of the  number of shares of Common  Stock  subject  to the option
would have been entitled  after the merger or  consolidation.  If the Company is
not the surviving corporation in any merger or consolidation,  or if the Company
is  liquidated,  or if at least 80% of the assets of the Company  are sold.  all
options outstanding under the Plan shall terminate; provided, however, that each
optionee   shall  have  the  right,   immediately   prior  to  such   merger  or
consolidation,  liquidation  or sale of assets to exercise such options in whole
or in part,  notwithstanding any provisions  contained in the Plan or the Option
Agreement (as defined in the Plan) to the contrary.

     The proposed amendment to the Plan will only apply to options granted on or
subsequent  to  December  5, 2000.  Under the  proposed  amendment  a "Change of
Control" shall mean: (i) a "Board Change" which, for purposes of the Plan, shall
have  occurred  if a majority  of the seats  (other  than  vacant  seats) on the
Company's  Board  were to be  occupied  by  individuals  who  were  neither  (A)
nominated by a majority of the Incumbent  Directors (as defined  herein) nor (B)
appointed by directors so nominated (an "Incumbent  Director" is a member of the
Board who has been either (1)  nominated  by a majority of the  directors of the
Company  then  in  office  or (2)  appointed  by  directors

                                       19

<PAGE>

so nominated, but excluding, for this purpose, any such individual whose initial
assumption  of office  occurs  as a result  of  either  an actual or  threatened
election  contest  or other  actual or  threatened  solicitation  of  proxies or
consents by or on behalf of a Person (as defined  herein) other than the Board);
or (ii) the acquisition by any  individual,  entity or group (within the meaning
of Section  13(d)(3) or 14(d)(2) of the Exchange Act) (a "Person") of beneficial
ownership  (within the meaning of Rule 13d-3  promulgated  under the  Securities
Exchange Act of 1934 (the "Exchange Act")) of a majority of the then outstanding
voting securities of the Company (the "Outstanding  Company Voting Securities");
provided, however, that the following acquisitions shall not constitute a Change
of Control:  (A) any  acquisition by the Company,  or (B) any acquisition by any
employee  benefit plan (or related trust) sponsored or maintained by the Company
or any  corporation  controlled  by the Company,  or (C) any public  offering or
private placement by the Company of its voting securities;  or (iii) a merger or
consolidation  of the Company with another  entity in which  neither the Company
nor a corporation that, prior to the merger or  consolidation,  was a subsidiary
of the Company, shall be the surviving entity; or (iv) a merger or consolidation
of the Company  following which either the Company or a corporation  that, prior
to the merger or  consolidation,  was a subsidiary of the Company,  shall be the
surviving entity and a majority of the Outstanding  Company Voting Securities is
owned by a Person or Persons who were not beneficial owners of a majority of the
Outstanding  Company  Voting  Securities  immediately  prior to such  merger  or
consolidation;  or (v) a voluntary or involuntary liquidation of the Company; or
(vi) a sale or  disposition  by the  Company  of at least 80% of its assets in a
single transaction or a series of transactions (other than a sale or disposition
of assets to a subsidiary of the Company in a transaction not involving a Change
of Control or a change in control of such  subsidiary).  If any of the Change in
Control  events  specified  in (iii),  (v) or (vi) above  occur all  outstanding
options  granted  under the Plan on or subsequent to December 5, 2000 which have
not vested in  accordance  with  their  terms as of the  effective  date of such
Change in Control event (the "Non-Vested  Options") shall vest immediately prior
to such  effective  date and the  holders  of such  Non-Vested  Options  will be
provided  a  reasonable  opportunity  to  exercise  such  options  prior to such
effective  date. In the event any of the Change in Control  events  specified in
(iii),  (v) or (vi)  above  occur,  all  options  granted  under  the Plan on or
subsequent to December 5, 2000 shall  terminate as of the effective date of such
Change in Control event to the extent not  previously  exercised.  If any of the
Change in Control events specified in (i), (ii) or (iv) above occur, all options
granted under the Plan on or subsequent to December 5, 2000 which have vested in
accordance  with their terms (the "Vested  Options") as of the effective date of
such Change in Control event,  shall remain exercisable in accordance with their
terms and all options  granted  under this Plan on or  subsequent to December 5,
2000 which are  Non-Vested  Options as of the  effective  date of such Change in
Control event,  shall vest and become exercisable in accordance with their terms
as of the  effective  date  of such  Change  in  Control  event.  The  foregoing
provisions  providing  for the vesting of  Non-Vested  Options  upon a Change in
Control  shall apply only to the extent the options  are  otherwise  eligible to
vest at the time of the Change in Control event in  accordance  with their terms
as determined by the Board or the Compensation  Committee.  For example,  if the
options  require that the holder be employed by the Company as of a certain date
in order for the options to vest and the Change in Control  event  occurs  after
such holder's  employment with the Company has terminated,  the options will not
vest upon the occurrence the Change in Control event.  The foregoing  provisions
providing for the vesting of Non-Vested  Options upon a Change in Control may be
modified or eliminated as to any option  granted under this Plan by the Board or
the Compensation Committee at the time such option is granted.


                                       20

<PAGE>

Administration

     The Plan is to be  administered  by  either  the  Board of  Directors  or a
committee  of at  least  two  directors  appointed  by the  Board.  The  Plan is
currently administered by the Compensation Committee.

Amendments and Termination

     Currently,  no options may be granted  under the Plan beyond  November  21,
2007. The Compensation Committee or the Board of Directors may terminate, amend,
or revise the Plan with respect to any shares as to which  options have not been
granted, but may not alter any previously granted options without the optionee's
consent.  Termination of the Plan will not affect  previously  granted  options.
Subject to the foregoing  restriction relating to outstanding options, the Board
can amend the Plan without stockholder  approval unless stockholder  approval is
required by applicable law or the rules of Nasdaq or any stock exchange on which
the Company's shares are then traded.

Capital Adjustments

     The aggregate  number of shares of Common Stock available for options,  the
shares  subject  to  any  option,   and  the  price  per  share,   will  all  be
proportionately  adjusted  for any  increase or decrease in the number of issued
shares of Common Stock  resulting  from (1) a subdivision  or  consolidation  of
shares or any other capital  adjustment,  (2) the payment of a stock dividend on
the  Company's  Common Stock,  or (3) other  increase or decrease in such shares
effected without receipt of  consideration  by the Company.

Tax Consequences

     An  optionee  will not  recognize  taxable  income for  Federal  income tax
purposes upon the receipt of an option under the Plan,  and the Company will not
be  entitled  to a deduction  upon the grant of an option.  Upon  exercise of an
option,  the optionee will recognize  ordinary income equal to the excess of the
fair  market  value on the date of exercise of the Common  Stock  received  upon
exercise  over the  exercise  price for such  Common  Stock.  However,  any such
optionee  who is subject to the  trading  restrictions  of Section  16(b) of the
Exchange Act would,  unless the optionee elected to recognize ordinary income on
the  date of  exercise,  recognize  ordinary  income  on the date  such  trading
restrictions  terminate (the "Deferred  Date").  The amount of such income would
equal the excess of the fair  market  value on the  Deferred  Date of the Common
Stock  received  upon  exercise of the option over the  exercise  price for such
Common Stock, and the holding period for long-term  capital gain treatment would
not begin until the Deferred  Date.  The Company will be entitled to a deduction
equal to the amount of ordinary  income  recognized  by any optionee at the same
time that such optionee recognized such income.

Eligible Participants

     As of October 20, 2000,  there were  approximately  112 persons eligible to
participate  in the Plan. Of these  eligible  participants,  eight are directors
(seven of whom are Independent  Directors),  one is an executive  officer who is
not a director  and the  remainder  are  employees  of the  Company  who are not
executive officers and consultants.

     For information concerning options granted under the Plan to directors, the
Chief  Executive  Officer  and the  Named  Executive  Officers  see  "Directors'
Compensation  - Directors'  Stock  Options,"  "Summary  Compensation  Table" and
"Option Grants In Last Fiscal Year."

     The Board of  Directors  recommends  a vote FOR  approval  of the  proposed
amendments to the  Non-Qualified  Stock Option Plan (Proposal No. 2 on the Proxy
Card).

                                       21

<PAGE>

                    PROPOSAL NO. 3 - RATIFICATION OF AUDITORS

     On  October  20,  2000,  the Audit  Committee  of the  Board of  Directors,
pursuant to authority granted by the Board of Directors,  approved the retention
of KPMG LLP ("KPMG"),  independent  certified public  accountants,  to audit the
consolidated financial statements of the Company for the fiscal year ending June
30, 2001. KPMG served as auditor of the consolidated financial statements of the
Company for the fiscal  years ended June 30, 2000,  June 30, 1999,  and June 30,
1998.  Representatives  of KPMG are expected to be present at the Annual Meeting
and will have the  opportunity to make a statement  should they desire to do so.
Such representatives are also expected to be available to respond to questions.

     The Board of Directors  recommends a vote FOR ratification of the selection
of KPMG LLP, independent certified public accountants, to audit the consolidated
financial  statements  of the  Company  for the fiscal year ending June 30, 2001
(Proposal No. 3 on the Proxy Card).

                          ANNUAL REPORT TO STOCKHOLDERS

     The Company's  Annual Report to Stockholders for the fiscal year ended June
30, 2000 accompanies this Proxy Statement.

                             STOCKHOLDERS' PROPOSALS

     It is  anticipated  that  the  Company's  fiscal  2001  Annual  Meeting  of
Stockholders will be held on or about December 4, 2001.  Stockholders who intend
to present  proposals at such Annual Meeting of  Stockholders  must submit their
proposals to the Secretary of the Company on or before July 5, 2001.

                                     GENERAL

     The cost of soliciting proxies will be borne by the Company. In addition to
mailing,  proxies  may  be  solicited  by  personal  interview,   telephone  and
telegraph,  and by  directors,  officers  and regular  employees of the Company,
without special compensation  therefor.  The Company expects to reimburse banks,
brokers  and  other  persons  for their  reasonable  out-of-pocket  expenses  in
handling proxy materials for beneficial owners of the Company's Common Stock.

     Unless  contrary  instructions  are indicated on the proxy card, all Common
Shares  or Series A  Preferred  Shares  represented  by valid  proxies  received
pursuant to this  solicitation  (and not revoked  before they are voted) will be
voted FOR the  election  of the  nominees  for  directors  named  herein and FOR
Proposal No. 2 and Proposal No. 3.

     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time before it is voted.  Proxies may be revoked by filing with
the Secretary of the Company  written notice of revocation  bearing a later date
than the proxy, by duly executing a subsequent proxy relating to the same Common
Shares or Series A  Preferred  Shares or by  attending  the Annual  Meeting  and
voting in person.  Attendance  at the Annual  Meeting  will not in and of itself
constitute  revocation of a proxy unless the stockholder votes his or her Common
Shares or Series A Preferred Shares in person at the Annual Meeting.  Any notice
revoking a proxy  should be sent to the  Secretary  of the  Company,  Kenneth J.
Zuerblis, at Enzon, Inc., 20 Kingsbridge Road, Piscataway, New Jersey 08854.

     The Board of Directors knows of no business other than that set forth above
to be  transacted at the meeting,  but if other matters  requiring a vote of the
stockholders  arise,  the  persons  designated  as proxies  will vote the Common
Shares or Series A Preferred  Shares  represented  by the proxies in  accordance
with their  judgment on such  matters.  If a  stockholder  specifies a different
choice on the proxy,  his or her Common Shares or Series A Preferred Shares will
be voted in accordance with the specification so made.

     Please complete,  sign and date the enclosed proxy card, which is revocable
as described herein, and mail it promptly in the enclosed postage-paid envelope.

                                       22

<PAGE>

     IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY.  WE URGE YOU TO FILL IN,
SIGN AND RETURN THE  ACCOMPANYING  PROXY CARD, NO MATTER HOW LARGE OR SMALL YOUR
HOLDINGS MAY BE.

                                      By order of the Board of Directors,



                                      Kenneth J. Zuerblis, Corporate Secretary

Piscataway, New Jersey
October 27, 2000


                                       23

<PAGE>

                                   Appendix A

                         CHARTER OF THE AUDIT COMMITTEE
                          OF THE BOARD OF DIRECTORS OF
                                   ENZON, INC.

Authority

The Audit Committee (the "Committee") of the Board of Directors (the "Board") of
Enzon,  Inc. (the Company) is established  pursuant to Article III, Section 8 of
the Company's  Amended and Restated  By-laws and Section  141(c) of the Delaware
General Corporation Law. The presence in person or by telephone of a majority of
the  Committee's  members  shall  constitute  a quorum for any  meetings  of the
Committee.  All actions of the Committee  will require the vote of a majority of
its members present at a meeting of the Committee at which a quorum is present.

Purpose

The primary  purpose of the Committee is to assist the Board in  fulfilling  its
responsibility  to  oversee  management's  conduct  of the  Company's  financial
reporting  process,  including by  overviewing  the financial  reports and other
financial  information provided by the Company to any governmental or regulatory
body,  the public or other  users  thereof,  the  Company's  systems of internal
accounting and financial controls, the annual independent audit of the Company's
financial  statements and the Company's legal  compliance and ethics programs as
established by management and the Board. In so doing,  it is the  responsibility
of the  Committee to maintain free and open means of  communication  between the
directors, the independent auditors, the internal auditors and the financial and
senior management of the Company.

In discharging its oversight role, the Committee is empowered to investigate any
matter  brought  to its  attention  with  full  access  to all  books,  records,
facilities and personnel of the Company and the power to retain outside counsel,
auditors or other experts for this  purpose.  The Board and the Committee are in
place to represent the Company's shareholders;  accordingly, the outside auditor
is ultimately accountable to the Board and the Committee.

The Committee shall review the adequacy of this Charter on an annual basis.

Membership

The  Committee  shall be comprised of not less than three  members of the Board,
and  the  Committee's  composition  will  meet  the  requirements  of the  Audit
Committee Policy of the NASD (the "NASD Policy").

Accordingly, all of the members will be directors:

1.   Who  have no  relationship  to the  Company  that  may  interfere  with the
     exercise of their independence from management and the Company; and

2.   Who are financially  literate or who become  financially  literate within a
     reasonable period of time after appointment to the Committee.  In addition,
     at least  one  member of the  Committee  will have  accounting  or  related
     financial management expertise.

Notwithstanding  paragraph  (1) above,  as  permitted  by the NASD  Policy,  one
director who is not independent and not a current  employee of the Company or an
immediate family member of an employee, may be appointed to the Committee if the
Board, under exceptional and limited  circumstances,  determines that membership
on the  Committee  by the  individual  is required by the best  interests of the
Company and its shareholders,  and the Board discloses, in the next annual proxy
statement  subsequent to such determination,  the nature of the relationship and
the reasons for that determination.

                                        1

<PAGE>

Meetings

The Committee  shall meet with such  frequency and at such intervals as it shall
determine is necessary to carry out its duties and responsibilities.  As part of
its purpose to foster open  communications,  the  Committee  shall meet at least
annually with management,  the head of the internal auditing  department and the
Company's  independent auditors in separate sessions to discuss any matters that
the  Committee  or each of these groups or persons  believe  should be discussed
privately.  In addition the Committee, or any member thereof designated Chairman
of the  Committee,  should  meet or confer  with the  independent  auditors  and
management quarterly to review the Company's periodic financial statements prior
to the their filing with the Securities and Exchange  Commission.  The Committee
may ask members of management and others to attend its meetings.

Key Responsibilities

The  Committee's  job is one of oversight and it  recognizes  that the Company's
management is responsible for preparing the Company's  financial  statements and
that  the  outside   auditors  are  responsible  for  auditing  those  financial
statements. Additionally, the Committee recognizes that financial management, as
well as the  outside  auditors,  have more  time,  knowledge  and more  detailed
information on the Company than do Committee members;  consequently, in carrying
out its oversight responsibilities, the Committee is not providing any expert or
special assurance as to the Company's  financial  statements or any professional
certification as to the outside auditor's work.

The  following  functions  shall  be  the  common  recurring  activities  of the
Committee in carrying out its oversight function.  These functions are set forth
as a guide with the understanding that the Committee may diverge from this guide
as appropriate given the circumstances.

     o    The Committee shall:

          -    review  with  management  and the  outside  auditors  the audited
               financial  statements  to be  included  in the  Company's  Annual
               Report on Form 10-K (or the  Annual  Report  to  Shareholders  if
               distributed  prior to the  filing of Form  10-K) and  review  and
               consider  with the outside  auditors  the matters  required to be
               discussed by Statement of Auditing Standard ("SAS") No. 61;

          -    as a whole,  or through  the  Committee  chair,  review  with the
               outside auditors the Company's  interim  financial  results to be
               included  in the  Company's  quarterly  reports  to be filed with
               Securities and Exchange Commission and the matters required to be
               discussed  by SAS No. 61;  this  review  will occur  prior to the
               Company's filing of the Form 10-Q;

          -    request  from the outside  auditors  annually,  a formal  written
               statement  delineating all relationships between the auditors and
               the Company consistent with Independence Standards Board Standard
               Number 1 ("Standard No. 1");

          -    discuss   with  the   outside   auditors   any   such   disclosed
               relationships   and  their   impact  on  the  outside   auditor's
               independence;

          -    recommend that the Board take  appropriate  action to oversee the
               independence of the outside auditors;

          -    prepare a report to be included in each annual proxy statement of
               the Company  commencing  after  December  15, 2000 which  states,
               among other  things,  whether (i) the  Committee has reviewed and
               discussed with management the audited financial  statements to be
               included in the Company's  Annual  Report on Form 10-K,  (ii) the
               Committee has discussed with the Company's  independent  auditors
               the matters  that the  auditors  are required to discuss with the
               Committee  by SAS No. 61,  (iii) the  Committee  has received the
               written  disclosures  and letter from the  Company's  independent
               auditors  required by Standard No. 1 and has  discussed  with the
               independent  auditors their independence,  and (iv) the Committee
               has   recommended  to  the  Board  that  the  audited   financial
               statements be included in the Company's Annual

                                        2

<PAGE>

               Report on Form 10-K for the last fiscal year;


          -    review with the  independent  auditors,  the  Company's  internal
               auditors and financial and accounting personnel, the adequacy and
               effectiveness  of the  accounting  and financial  controls of the
               Company and elicit any  recommendations  for the  improvement  of
               such control  procedures  or  particular  areas where new or more
               detailed controls or procedures are desirable;

          -    review the internal audit function of the Company,  including the
               independence  and  authority of its  reporting  obligations,  the
               proposed audit plans for the coming year, and the coordination of
               such plans with the independent auditors;

          -    review  accounting and financial  human  resources and succession
               planning within the Company;

          -    submit  the  minutes  of all  meetings  of the  Committee  to, or
               discuss the matters discussed at each Committee meeting with, the
               Board; and

          -    investigate any matter brought to its attention  within the scope
               of its duties,  with the power to retain outside counsel for this
               purpose if, in its judgment, that is appropriate.


     o    The Committee recognizes the outside auditors' ultimate accountability
          to the Board and the Committee as  representatives of the shareholders
          of the Company. In connection therewith, the Committee, subject to any
          action  that may be taken by the full Board,  shall have the  ultimate
          authority and  responsibility  to select (or nominate for  shareholder
          approval),  evaluate  and,  where  appropriate,  replace  the  outside
          auditor.


                                        3

<PAGE>

                                   Appendix B

                                   ENZON, INC.

                 NON-QUALIFIED STOCK OPTION PLAN, AS AMENDED(1)

A.   Purpose and Scope

     The purpose of this Plan is to encourage  stock  ownership by employees and
directors  of,  and  independent   consultants  to,  Enzon,   Inc.,  a  Delaware
corporation,  and its subsidiaries (herein called the "Company"),  to provide an
incentive  to such  persons to  develop,  expand and  improve  the  profits  and
prosperity of the Company, and to assist the Company in attracting key personnel
and consultants through the grant of Options to purchase shares of the Company's
Common Stock.

B.   Definitions

     Unless otherwise required by the context:

     1. "Board" shall mean the Board of Directors of the Company.

     2. "Board  Change"  shall have  occurred if a majority of the seats  (other
than vacant  seats) on the Company's  Board of Directors  were to be occupied by
individuals who were

----------
(1) The Plan was  amended by vote of the Board of  Directors  on each of January
10, 1990,  February 6, 1990,  April 25, 1990,  February 23, 1991,  May 30, 1991,
November 21, 1991, with all such amendments approved by vote of the Stockholders
on January 22,  1992;  amended by vote of the Board of Directors on December 28,
1992 with such  amendment  ratified by vote of the  Stockholders  on February 8,
1993;  amended by vote of the Board of Directors on September 13, 1993 with such
amendment  ratified by vote of the Stockholders on December 7, 1993;  amended by
the Board of Directors on July 17, 1995, with such amendment ratified by vote of
the Stockholders on December 5, 1995;  amended by vote of the Board of Directors
on October 7, 1997, with such amendment  ratified by vote of the Stockholders on
December  2, 1997;  amended by the Board of  Directors  on October 20, 1998 with
such amendment ratified by vote of the Stockholders on December 1, 1998; amended
by the Board of Directors on May 18, 1999 with such  amendment  ratified by vote
of the  Stockholders  on  December  7, 1999 (to take  effect  January 1,  2000);
amended by the Board of Directors on October 20, 2000, with such amendment to be
voted on by the Stockholders on December 5, 2000.

                                       1

<PAGE>

neither  nominated by a majority of the  Incumbent  Directors  nor  appointed by
directors so nominated.

     3. "Committee" shall mean the Compensation Committee, which is appointed by
the Board, and which shall be composed of at least two Non-Employee Directors.

     4. "Company" shall mean Enzon, Inc. and its subsidiaries.

     5. "Code" shall mean the Internal Revenue Code of 1986, as amended.

     6.  "Incumbent  Director" shall mean a member of the Board of Directors who
has been either  nominated by a majority of the directors of the Company then in
office or appointed by directors so nominated,  but excluding, for this purpose,
any such  individual  whose  initial  assumption of office occurs as a result of
either an actual or  threatened  election  contest or other actual or threatened
solicitation  of proxies or consents by or on behalf of a Person  other than the
Board of Directors.

     7.  "Independent  Director" shall mean a director who is not an employee of
the Company.

     8.  "Non-Employee  Director" shall have the meaning  ascribed in Rule 16b-3
("Rule  16b-3")  promulgated  under  the  Securities  Exchange  Act of 1934,  as
amended.

     9. "Option" shall mean a right to purchase Stock,  granted  pursuant to the
Plan.

     10. "Option Price" shall mean the purchase price for Stock under an Option,
as determined in Section F below.

                                       2

<PAGE>

     11.  "Participant" shall mean an employee of the Company, a director of the
Company, a consultant to the Company, or any person to whom an Option is granted
under the Plan.

     12. "Person" shall mean any individual,  entity or group within the meaning
of Section  13(d)(3) or  14(d)(2) of the  Securities  Exchange  Act of 1934,  as
amended.

     13. "Plan" shall mean this Enzon, Inc.  Non-Qualified Stock Option Plan, as
amended.

     14. "Stock" shall mean the Common Stock of the Company, par value $.01.

C.   Stock to be Optioned

     Subject to the  provisions of Section L of the Plan,  the maximum number of
shares of Stock that may be optioned or sold under the Plan is 7,900,000 shares.
Such shares may be treasury,  or authorized but unissued shares of, the Stock of
the Company.

D.   Administration

     The Plan shall be administered  by the Committee or the Board.  Two members
of the  Committee  shall  constitute a quorum for the  transaction  of business.
Except as provided in Section Q hereof,  the  Committee  or the Board shall make
all decisions  with respect to the operation of the Plan, the  participation  in
the Plan by employees or directors of, or consultants  to the Company,  and with
respect to the extent of that participation. The interpretation and construction
of any  provision of the Plan by the Board or the Committee  shall be final.  No
member  of the  Board  or the  Committee  shall  be  liable  for any  action  or
determination made by him in good faith.



                                       3
<PAGE>

E.   Eligibility

     The Board or the Committee may grant Options to any employee  (including an
employee who is a director or an officer),  or any person who is not an employee
who is a director or an officer, or any person who is not an employee and serves
as a director of the Company,  or any consultant to the Company.  Options may be
awarded by the Board or the  Committee  at any time and from time to time to new
Participants,  or to then current Participants, or to a greater or lesser number
of Participants, and may include or exclude previous Participants, as the Board,
or the Committee  shall  determine.  Options granted at different times need not
contain similar provisions.

F.   Option Price

     The  purchase  price  for Stock  under  each  Option  shall be at least 100
percent of the fair market value of the Stock at the time the Option is granted,
but in no event less than the par value of the Stock.  The fair market  value of
the Company's Stock shall be determined as follows:

(a)  If the Common Stock continues to be traded on the  over-the-counter  market
     as a National Market System Security or is traded on a national  securities
     exchange,  the fair market  value of the Stock  shall be the  closing  sale
     price on such day that the Option is granted as  reported  by the  National
     Association of Securities Dealers Automated  Quotation System ("NASDAQ") or
     the national securities exchange on which the Stock is trading, as the case
     may be; or



                                       4
<PAGE>

(b)  If the  Common  Stock  ceases  to be  traded as a  National  Market  System
     Security but  continues to be traded on the  over-the-counter  market,  the
     fair  market  value of the Stock shall be the closing bid price on such day
     that the Option is granted as reported by NASDAQ; or

(c)  If the Common Stock ceases to be traded on the over-the-counter  market and
     is not traded on a national securities  exchange,  the current market value
     shall be determined by a reputable  investment banking firm retained by the
     Board.

G.   Terms and Conditions of Options

     Except as provided  in Section Q hereof,  Options  granted  pursuant to the
Plan shall be authorized by the Board or the Committee and shall be evidenced by
agreements  ("Option  Agreements")  in such form as the Board or the  Committee,
shall  from time to time  approve.  Such  Agreements  shall  comply  with and be
subject to the following terms and conditions:

     1. Employment Agreement: The Board or the Committee may, in its discretion,
include in any Option granted under the Plan to a Participant who is an employee
of the Company a  condition  that the  Participant  shall agree to remain in the
employ  of,  and/or to render  services  to,  the  Company  for a period of time
(specified in the Option Agreement) following the date the Option is granted. No
such agreement shall impose upon the Company,  however, any obligation to employ
the  Participant  for any period of time,  except as otherwise  agreed to by the
Company.

     2. Time and Method of  Payment:  The Option  Price shall be paid in full in
cash,  by  certified  check or  official  bank  check,  at the time an Option is
exercised  under the Plan. If the Board or the Committee in its sole  discretion
so authorizes, payment may be made by exchange


                                       5
<PAGE>

of shares of the Company's Common Stock previously owned by the optionee, having
the same fair market value as  determined  in the manner set forth in Section F.
In addition, at the discretion of the Committee, the optionee may also surrender
that  number of shares of Common  Stock of the  Company  subject to such  option
having the aggregate fair market value (as determined in the manner set forth in
Section F) equivalent to the aggregate  Option Price of the exercised  option in
lieu of cash payment of the Option Price.  Without payment by one of the methods
described  above,  an  exercise  of any Option  granted  under the Plan shall be
invalid  and of no  effect.  Promptly  after the  exercise  of an Option and the
payment of the full  Option  Price,  the  Participant  shall be  entitled to the
issuance of a stock  certificate  evidencing  his or her  ownership of the Stock
issuable  under such Option.  A  Participant  shall have none of the rights of a
stockholder  until the Option is duly exercised,  and no adjustment will be made
for  dividends  or other  rights for which the record  date is prior to the date
such Option is duly exercised.

     3. Number of Shares:  Each Option shall state the total number of shares of
Stock to which it pertains.

     4. Option Period and Limitations on Exercise of Options: Except for Options
granted pursuant to Section Q hereof, the Board or Committee shall determine the
period of time during which an Option may be exercised,  provided, however, that
no Option may be exercised after the expiration of ten years from the date it is
granted.  Except for Options granted pursuant to Section Q hereof,  the Board or
the  Committee  may,  in its  discretion,  provide  that  an  Option  may not be
exercised in whole or in part for any period or periods of time specified in the
Option  Agreement;  provided,  however,  that no Option  granted  subsequent  to
November 21, 1991 may be  exercisable  for a minimum of six months from the date
of grant.  Options  granted  pursuant to Section Q hereof will be exercisable in
accordance with Section R hereof. Except as provided in


                                       6
<PAGE>

the Option  Agreement  and in this Section  G(4),  an Option may be exercised in
whole or in part at any time during its term.  No Option may be exercised  for a
fractional share of Stock.

H.   Termination of Employment

     Except as provided in Section I below,  if an employee who is a Participant
ceases to be  employed  by the  Company,  his or her  Options  unless  otherwise
exercised,  shall  terminate  as of the close of business on the one hundred and
ninetieth (190th) day following the termination of the Participant's  employment
with the Company;  provided,  however, that such Participant may exercise his or
her Options  during such one hundred and ninety (190) day period  following such
termination of employment  only to the extent that he or she would  otherwise be
entitled  to  exercise  such  Options  during such  period;  provided,  further,
however,  that in no event  shall any Option be  exercisable  more than ten (10)
years from the date it was granted.  Notwithstanding the foregoing, the Board or
the  Committee  may cancel an Option during the one hundred and ninety (190) day
period referred to in this section,  if the Participant engages in employment or
activities contrary,  in the opinion of the Board or the Committee,  to the best
interests of the Company.  The Board or the  Committee  shall  determine in each
case whether a termination of employment  shall be considered a retirement  with
the consent of the Company,  and,  subject to applicable law, whether a leave of
absence shall constitute a termination of employment.  Any such determination of
the  Board or the  Committee  shall  be  final  and  conclusive.  The  foregoing
provisions  may be modified or waived by the Board or the  Committee and do not,
in any case,  apply to any  Participant  who is not an employee of the  Company.
Except  for  Options  granted  pursuant  to  Section Q hereof,  the Board or the
Committee will determine what, if any, provisions for earlier termination of the
Option will be included in the Option  Agreement issued to any person who is not
an employee. The Board or the Committee will determine who shall be


                                       7
<PAGE>

deemed to be an employee of the Company for the  purposes of this  Section H and
Section I below at the time the Option is granted.

I.   Rights in Event of Death

     If an employee who is a Participant dies while employed by the Company,  or
within three months  after having  retired with the consent of the Company,  and
without   having  fully   exercised  his  or  her  Options,   the  executors  or
administrators,  or legatees or heirs, of his or her estate shall have the right
to  exercise  such  Options to the extent  that such  deceased  Participant  was
entitled  to  exercise  the  Options on the date of his or her death;  provided,
however,  that in no event shall the Options be exercisable  more than ten years
from the date they were  granted.  The foregoing  provisions  may be modified or
waived  by the Board or the  Committee  and do not,  in any  case,  apply to any
Participant  who is not an employee of the Company.  Except for Options  granted
pursuant to Section Q hereof, the Board or the Committee will determine what, if
any,  provisions  concerning exercise of the Option upon the death of the holder
will be  included  in the  Option  Agreement  issued to any person who is not an
employee.

J.   No Obligations to Exercise Option

     The granting of an Option shall impose no obligation  upon the  Participant
to exercise such Option.

K.   Assignability

     At the discretion of the Committee, Options may be exercised by transferees
or  beneficiaries  who are  family  members of a  Participant.  No Option may be
pledged, alienated,


                                       8
<PAGE>

attached  or  otherwise  encumbered,   and  any  purported  pledge,  alienation,
attachment of encumbrance  thereof shall be void and  unenforceable  against the
Company.

L.   Effect of Change in Stock Subject to the Plan

          (a) The  aggregate  number of shares of Stock  available  for  Options
     under the Plan, the shares subject to any Option,  and the price per share,
     shall all be  proportionately  adjusted for any increase or decrease in the
     number of issued shares of Stock  subsequent  to the effective  date of the
     Plan  resulting from (1) a subdivision  or  consolidation  of shares or any
     other  capital  adjustment,  (2) the  payment  of a stock  dividend  on the
     Company's  Common Stock,  or (3) other  increase or decrease in such shares
     effected without receipt of  consideration by the Company.

          (b) For Options issued prior to December 5, 2000, upon  dissolution or
     liquidation of the Company,  all Options  outstanding  under the Plan shall
     terminate;  provided, however, that each Participant (and each other person
     entitled  under  Section I to  exercise  an  Option)  shall have the right,
     immediately  prior to such  dissolution  or  liquidation,  to exercise such
     Participant's  Options in whole or in part,  notwithstanding any provisions
     contained in the Plan or the Option Agreement to the contrary.

          (c) For Options  issued prior to December 5, 2000:  (i) if the Company
     shall be the  surviving  corporation  in any merger or  consolidation,  any
     Option shall pertain, apply, and relate to the securities to which a holder
     of the  number of shares of Stock  subject  to the  Option  would have been
     entitled after the merger or consolidation;  and (ii) if the Company is not
     the  surviving  corporation,  upon a merger or  consolidation,  all Options
     outstanding under the Plan shall terminate;  provided,  however,  that each



                                       9
<PAGE>

     Participant  (and each other person entitled under Section I to exercise an
     Option)  shall  have  the  right,  immediately  prior  to  such  merger  or
     consolidation,  to exercise such Participant's Options in whole or in part,
     notwithstanding  any  provisions  contained  in  the  Plan  or  the  Option
     Agreement to the contrary.

          (d) For Options  issued on or subsequent to December 5, 2000 a "Change
     in Control" shall mean: (i) a Board Change;  or (ii) the acquisition by any
     Person  of  beneficial   ownership   (within  the  meaning  of  Rule  13d-3
     promulgated  under the Exchange Act) of a majority of the then  outstanding
     voting  securities  of  the  Company  (the   "Outstanding   Company  Voting
     Securities");  provided, however, that the following acquisitions shall not
     constitute a Change of Control:  (A) any acquisition by the Company, or (B)
     any acquisition by any employee  benefit plan (or related trust)  sponsored
     or maintained by the Company or any corporation  controlled by the Company,
     or (C) any public  offering  or  private  placement  by the  Company of its
     voting  securities;  or (iii) a merger or consolidation of the Company with
     another entity in which neither the Company nor a corporation  that,  prior
     to the merger or consolidation,  was a subsidiary of the Company,  shall be
     the  surviving  entity;  or (iv) a merger or  consolidation  of the Company
     following  which  either the Company or a  corporation  that,  prior to the
     merger or  consolidation,  was a subsidiary  of the  Company,  shall be the
     surviving  entity  and  a  majority  of  the  Outstanding   Company  Voting
     Securities is owned by a Person or Persons who were not "beneficial owners"
     of a majority of the  Outstanding  Company  Voting  Securities  immediately
     prior to such merger or  consolidation;  or (v) a voluntary or  involuntary
     liquidation of the Company; or (vi) a sale or disposition by the Company of
     at  least  80% of  its  assets  in a  single  transaction  or a  series  of
     transactions (other than a


                                       10
<PAGE>

     sale  or  disposition  of  assets  to a  subsidiary  of  the  Company  in a
     transaction  not  involving  a Change of  Control or a change in control of
     such  subsidiary).  If any of the Change in  Control  events  specified  in
     (iii),  (v) or (vi) above occur all  outstanding  Options granted under the
     Plan on or  subsequent  to  December  5,  2000  which  have not  vested  in
     accordance  with their  terms as of the  effective  date of such  Change in
     Control event (the "Non-Vested  Options") shall vest  immediately  prior to
     such  effective  date and the holders of such  Non-Vested  Options  will be
     provided a reasonable  opportunity  to exercise  such Options prior to such
     effective date. In the event any of the Change in Control events  specified
     in (iii), (v) or (vi) above occur, all Options granted under the Plan on or
     subsequent to December 5, 2000 shall  terminate as of the effective date of
     such Change in Control event to the extent not previously exercised. If any
     of the Change in Control events specified in (i), (ii) or (iv) above occur,
     all Options  granted  under the Plan on or  subsequent  to December 5, 2000
     which have vested in accordance with their terms (the "Vested  Options") as
     of the  effective  date of such  Change  in  Control  event,  shall  remain
     exercisable  in accordance  with their terms and all Options  granted under
     this Plan on or  subsequent  to  December  5,  2000  which  have  vested in
     accordance with their terms (the "Non-Vested  Options") as of the effective
     date of such Change in Control event,  shall vest and become exercisable in
     accordance  with their  terms as of the  effective  date of such  Change in
     Control  event.  The  foregoing  provisions  providing  for the  vesting of
     Non-Vested  Options upon a Change in Control shall apply only to the extent
     the  Options  are  otherwise  eligible to vest at the time of the Change in
     Control event in accordance  with their terms as determined by the Board or
     the  Committee.  For  example,  if the Options  require  that the holder be
     employed  by the  Company as of a certain  date in order for the Options to
     vest and the Change in Control event occurs after


                                       11
<PAGE>

     such holder's employment with the Company has terminated,  the Options will
     not vest upon the  occurrence  the Change in Control  event.  The foregoing
     provisions providing for the vesting of Non-Vested Options upon a Change in
     Control may be modified or eliminated  as to any option  granted under this
     Plan by the Board or the Committee at the time such Option is granted.

M.   Amendment and Termination

     Subject  to the  last  paragraph  of  this  Section  M,  the  Board  or the
Committee, by resolution, may terminate,  amend, or revise the Plan with respect
to any shares as to which Options have not been  granted.  Neither the Board nor
the  Committee  may,  without the  consent of the holder of an Option,  alter or
impair  any  Option  previously  granted  under the Plan,  except as  authorized
herein.  Unless sooner terminated,  the Plan shall remain in effect for a period
of twenty  years  from the date of the  Plan's  initial  adoption  by the Board.
Termination of the Plan shall not affect any Option previously granted.

     No such amendment will require  stockholder  approval,  unless  stockholder
approval is  required by either the rules of Nasdaq or any other stock  exchange
upon which the Company's securities shall be listed or any applicable law.

N.   Agreement and Representation of Participants

     As a condition to the exercise of any portion of an Option, the Company may
require the person  exercising  such Option to represent and warrant at the time
of such  exercise  that  any  shares  of  Stock  acquired  at  exercise  are not
registered  under  the  Securities  Act of 1933  (the  "Act"),  are  "restricted
securities"  as that  term is  defined  in Rule 144  under the Act and are being

                                       12
<PAGE>

acquired  only for  investment  and  without any  present  intention  to sell or
distribute  such shares,  if, in the opinion of counsel for the Company,  such a
representation   is  required  under  the  Act  or  any  other  applicable  law,
regulation, or rule of any governmental agency.

O.   Reservation of Shares of Stock

     The Company,  during the term of this Plan,  will at all times  reserve and
keep  available,  and will  seek or  obtain  from  any  regulatory  body  having
jurisdiction any requisite  authority necessary to issue and to sell, the number
of shares of Stock that shall be sufficient to satisfy the  requirements of this
Plan.  The  inability of the Company to obtain from any  regulatory  body having
jurisdiction  the authority  deemed necessary by counsel for the Company for the
lawful issuance and sale of its Stock hereunder shall relieve the Company of any
liability  in  respect  of the  failure  to issue or sell  Stock as to which the
requisite authority has not been obtained.

P.   Effective Date of Plan

     The Plan shall be effective  as of the date it is initially  adopted by the
Board,  provided  that  Section Q shall not become  effective  until it has been
ratified by the stockholders.

Q.   Grant of Options to Independent Directors

          (a) Prior to January 1, 2000 each Independent  Director  automatically
     received an Option to purchase 60,000 shares of Stock on each of January 2,
     1994 and January 2, 1997 (the "Old Regular Independent Director Grant").

          (b) Each Independent Director shall automatically  receive,  effective
     as of January  1, 2000,  an annual  grant of an Option to  purchase  10,000
     shares of Stock on each  January  2 during  the Term of this Plan (the "New
     Regular Independent Director


                                       13
<PAGE>

     Grant").  Notwithstanding  the  foregoing,  should  the date on which a New
     Regular  Independent  Director Grant is scheduled to be awarded pursuant to
     the  preceding  sentence  fall on a Saturday,  Sunday or  holiday,  the New
     Regular  Independent  Director Grant shall be awarded on the first business
     day immediately following such scheduled date.

          (c) On the date of each Independent Director's initial election to the
     Board,  prior to  January  1,  2000,  pursuant  to a vote of the  Company's
     stockholders  or  the  Board,  such  newly-elected   Independent   Director
     automatically  received  (i) an Option to  purchase a pro rata share of the
     shares of Stock  underlying  an Option  granted  pursuant to an Old Regular
     Independent  Director  Grant,  which  was  equal  to the  product  of 1,666
     multiplied  by the number of whole months  remaining in the relevant  three
     year period (the "Old Pro Rata Independent  Director  Grant");  and (ii) an
     Option  to  purchase  10,000  shares  of Stock  (the  "Initial  Independent
     Director Election Grant").

          (d) On the date of each Independent Director's initial election to the
     Board, effective as of January 1, 2000, pursuant to a vote of the Company's
     stockholders or the Board, such  newly-elected  Independent  Director shall
     automatically  receive (i) an Option to  purchase  that number of shares of
     Stock equal to the product of 833  multiplied by the number of whole months
     remaining  in the  calendar  year during  which such  Independent  Director
     joined the Board (the "New Pro Rata Independent  Director Grant"); and (ii)
     the Initial Independent Director Election Grant.



                                       14
<PAGE>

R.   Exercise Period of Options Granted to Independent Directors

     Subject  to the last  paragraph  of this  Section  R, each  Option  granted
pursuant to the Plan shall vest and become exercisable as follows:

     1. Those Options granted  pursuant to an Old Regular  Independent  Director
Grant  shall  vest and  become  exercisable  as to  20,000  shares  on the first
anniversary of the date of grant; as to 20,000 shares on the second  anniversary
of the  date of  grant;  and as to the  remaining  20,000  shares  on the  third
anniversary of the date of grant.

     2. Those Options granted pursuant to an Old Pro Rata  Independent  Director
Grant shall vest and become exercisable as to that number of shares equal to the
product of 1,666 multiplied by the number of whole months remaining in the first
calendar  year in which the  Independent  Director is elected  initially  to the
Board on the January 1st following such Independent  Director's initial election
to the Board; and as to any remaining shares in accordance with the schedule for
Options  granted  pursuant  to an Old  Regular  Independent  Director  Grant  as
provided in Section R(1) hereof.

     3. Those Options  granted  pursuant to a New Regular  Independent  Director
Grant shall vest and become exercisable on the January 1st following the date on
which such Option was granted.

     4. Those Options granted  pursuant to a New Pro Rata  Independent  Director
Grant  shall vest and become  exercisable  on the  January  1st  following  such
Independent Director's initial election to the Board.



                                       15
<PAGE>

     5.  Those  Options  granted  pursuant  to an Initial  Independent  Director
Election  Grant  shall  become  exercisable  as to  5,000  shares  on the  first
anniversary  of  the  date  of  grant;  and as to  5,000  shares  on the  second
anniversary of the date of grant.

     Notwithstanding  the  foregoing,  an  Option  shall  not  vest  and  become
exercisable  as to the  relevant  shares  unless such  Independent  Director has
served  continuously  on the Board during the year  preceding  the date on which
such Options are scheduled to vest and become exercisable, or from the date such
Independent  Director  joined the board should such  Independent  Director  have
joined the board  during such  preceding  year;  provided,  however,  that if an
Independent Director does not fulfill such continuous service requirement due to
such  Independent  Director's  death or disability  all Options  granted to such
Independent  Director  pursuant to Section Q hereof shall  nonetheless  vest and
become exercisable as provided in this Section R. For purposes of this Section R
"disability"  shall  mean a  physical  or mental  condition  which  prevents  an
Independent  Director from  performing his duties as an Independent  Director of
the  Company  for a  continuous  six month  period or for a total of six  months
during  any 18  month  period.  Any  Option  which  does  not  vest  and  become
exercisable  in  accordance  with this  Section R shall  terminate  and be of no
further  force or  effect.  Subject  to the  provisions  of Section L, an Option
granted under Section Q shall remain  exercisable for a period of ten (10) years
from the date it was granted.



                                       16



<PAGE>

Proxy Card

                                   ENZON, INC.

                 Annual Meeting of Stockholders December 5, 2000
           This Proxy Is Solicited on Behalf of the Board of Directors

     Peter G. Tombros and Kenneth J. Zuerblis and each of them, as proxies, with
full power of substitution  in each of them, are hereby  authorized to represent
and to vote, as  designated  below and on the reverse side, on all proposals and
in the  discretion  of the proxies on such other  matters as may  properly  come
before the annual meeting of stockholders  of Enzon,  Inc. (the "Company") to be
held on  December  5,  2000 or any  adjournment(s),  postponement(s),  or  other
delay(s) thereof (the "Annual  Meeting"),  all shares of stock of the Company to
which the undersigned is entitled to vote at the Annual Meeting.

     UNLESS  OTHERWISE  DIRECTED,  THIS PROXY WILL BE VOTED "FOR" PROPOSALS 1, 2
and 3 AND WILL BE VOTED IN THE  DISCRETION  OF THE PROXIES ON SUCH OTHER MATTERS
AS MAY  PROPERLY  COME  BEFORE  THE  ANNUAL  MEETING.  THE  BOARD  OF  DIRECTORS
HAS PROPOSED AND RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" PROPOSALS 1, 2 and 3.

(1)  Election of the  following  nominees as Class II Directors to serve in such
     capacities until their successors are duly elected and qualified:


             RANDY H. THURMAN                   DR. DAVID W. GOLDE


(Authority to vote for any nominee(s) may be withheld by lining through the
name(s) of any such nominee(s).)

             [ ] FOR all nominees          [ ] WITHHOLD authority for all


(2)  Proposal to approve the  amendment  to the  Company's  Non-Qualified  Stock
     Option Plan, as set forth in the Company's  Proxy  Statement  dated October
     27, 2000.

             [ ] FOR              [ ] AGAINST              [ ] ABSTAIN



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(3)  Ratification  of the  selection  of  KPMG  LLP to  audit  the  consolidated
     financial  statements  of the  Company  for the fiscal year ending June 30,
     2001.

             [ ] FOR              [ ] AGAINST              [ ] ABSTAIN

[ ]  Please check this box if you expect to attend the Annual Meeting in person.

                              (Please  sign exactly as name appears to the left,
                              date  and  return.  If  shares  are  held by joint
                              tenants,   both  should  sign.   When  signing  as
                              attorney,  executor,  administrator,  trustees  or
                              guardian,  please  give full  title as such.  If a
                              corporation, please sign in full corporate name by
                              president  or  other  authorized   officer.  If  a
                              partnership,  please sign in  partnership  name by
                              authorized person.)


                           Date:
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                                                 Sign Here

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                                        Signature (if held jointly)

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                           Capacity (Title or Authority, i.e. Executor, Trustee)

                           PLEASE SIGN, DATE AND MAIL YOUR PROXY TODAY.




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