ENZON INC
8-K, 2000-11-06
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                Kevin T. Collins
                                 (212) 415-9319


                                November 6, 2000


Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549

Attn: Filing Desk


                   Re: Enzon, Inc.- Current Report on Form 8-K


Ladies and Gentlemen:

     On behalf of our client Enzon, Inc. (the "Company"), we are transmitting
electronically the Company's Current Report on Form 8-K (the "Form 8-K") dated
November 6, 2000.

     Please note that the Form 8-K filed herewith contains a conformed signature
and that an original, manual signature will be retained in the Company's records
for five (5) years.

                                                       Very truly yours,

                                                       /s/ KEVIN T. COLLINS
                                                       -------------------------
                                                       Kevin T. Collins


cc: Kenneth J. Zuerblis



<PAGE>


                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported) November 6, 2000


                                   ENZON, INC.
             (Exact name of registrant as specified in its charter)






         Delaware                    0-12957                       22-237286
(State or other jurisdiction       (Commission                   (IRS Employer
     of incorporation)             File Number)                  Identification)



                20 Kingsbridge Road, Piscataway, New Jersey 08854
               (Address of principal executive offices) (Zip Code)



       Registrant's telephone number, including area code: (732) 980-4500



                                       N/A
          (Former name or former address, if changed since last report)



                                       1

<PAGE>


Item 5.  Other Events

     Enzon, Inc. announced today that Peter Tombros,  (58),  President and Chief
Executive  Officer,  intends to exercise  options to acquire  300,000  shares of
Enzon common stock and is irrevocably instructing his investment advisor to sell
over time a portion  of those  shares.  These  options  will  expire in 2002 and
represent  approximately  20% of the options to purchase Enzon common stock held
by Mr. Tombros. To date, Mr. Tombros, who has been President and Chief Executive
Officer of Enzon since 1994,  has never sold any shares of the Company's  common
stock.  The proposed  sales are focused on those options which are due to expire
in the near future.  Mr. Tombros has instructed his investment advisor to retain
a portion of the underlying  shares of common stock for long-term  appreciation.
Other than this limitation,  Mr. Tombros'  investment advisor will exercise sole
discretion  with  respect to the sales of these  shares of common stock and will
not consult with Mr. Tombros prior to effecting any such sales. Mr. Tombros will
not exercise any subsequent influence over such sales.

     Except for the historical information herein, the matters discussed in this
news release  include  forward-looking  statements  that may involve a number of
risks and  uncertainties.  Actual  results may vary  significantly  based upon a
number of factors which are described in the  Company's  Form 10-K,  Form 10-Q's
and  Form  8-K on file  with the SEC,  including  without  limitation,  risks in
obtaining and maintaining  regulatory approval for expanded indications,  market
acceptance  of and  continuing  demand for  Enzon's  products  and the impact of
competitive  products and pricing.  The  forward-looking  statements included in
this news release provide the information  included in such statements as of the
date of this news  release and the Company  disclaims  any duty to update any of
such statements.

                                       2

<PAGE>


                                   SIGNATURES


     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

Dated: November 6, 2000


                                                         ENZON, INC.
                                             -----------------------------------
                                                        (Registrant)


                                         By: /s/ Kenneth J. Zuerblis
                                             -----------------------------------
                                             Kenneth J. Zuerblis
                                             Vice President,
                                             Finance and Chief Financial Officer


                                        3



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