ENZON INC
10-Q, 2000-11-13
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-Q
                QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


For the Quarter Ended September 30, 2000             Commission File No. 0-12957


                          [GRAPHIC OMITTED] ENZON, INC.

             (Exact name of registrant as specified in its charter)


           Delaware                                           22-2372868
(State or other jurisdiction of                              (IRS Employer
incorporation or organization)                               Identification No.)


20 Kingsbridge Road, Piscataway, New Jersey                             08854
(Address of principal executive offices)                              (Zip Code)


Registrant's telephone number, including area code: (732) 980-4500

Securities registered pursuant to Section 12(b) of the Act:  None

Securities registered pursuant to Section 12(g) of the Act:

                          Common Stock, $.01 par value
                                (Title of class)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days. Yes X No


     As of November 8, 2000, there were 41,478,671 shares of Common Stock, par
value $.01 per share, outstanding.


<PAGE>


PART I FINANCIAL INFORMATION
Item 1. Financial Statements







                          ENZON, INC. AND SUBSIDIARIES
                      CONSOLIDATED CONDENSED BALANCE SHEETS
                      September 30, 2000 and June 30, 2000

                                                   September 30,    June 30,
                                                       2000           2000
                                                    (unaudited)         *
                                                   ------------   ------------
ASSETS
Current assets:
  Cash and cash equivalents                        $ 27,255,390   $ 31,935,410
  Short-term investments                             30,637,661     16,986,278
  Accounts receivable                                 5,669,253      5,442,455
  Inventories                                           955,099        946,717
  Other current assets                                2,687,097        487,657
  Accrued interest receivable                         1,712,672      1,782,227
                                                   ------------   ------------
     Total current assets                            68,917,172     57,580,744
                                                   ------------   ------------

Property and equipment                               12,566,963     12,439,729
  Less accumulated depreciation and amortization     10,746,031     10,650,859
                                                   ------------   ------------
                                                      1,820,932      1,788,870
                                                   ------------   ------------

Other assets:
  Investments                                        63,587,023     69,557,481
  Other assets                                          603,851        426,732
  Patents, net                                          862,936        898,423
                                                   ------------   ------------
                                                     65,053,810     70,882,636
                                                   ------------   ------------
Total assets                                       $135,791,914   $130,252,250
                                                   ============   ============

LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
  Accounts payable                                    2,945,472      2,465,360
  Accrued expenses                                    7,810,869      5,706,811
                                                   ------------   ------------
     Total current liabilities                       10,756,341      8,172,171
                                                   ------------   ------------
Accrued rent                                            601,295        607,914
Unearned Revenue-Aventis                                510,001        510,001
                                                   ------------   ------------
                                                      1,111,296      1,117,915
                                                   ------------   ------------

Stockholders' equity:
   Preferred stock-$.01 par value,
   authorized 3,000,000 shares;
   issued and outstanding 7,000
   shares at September 30, 2000 and
   June 30, 2000 (liquidation
   preference aggregating $322,000
   at September 30, 2000 and
   $319,000 at June 30, 2000)                              70               70
   Common stock-$.01 par value,
   authorized 60,000,000 shares; issued and
   outstanding 41,442,086 shares at
   September 30, 2000 and
   40,838,115 shares at June 30, 2000                 414,421          408,381
   Additional paid-in capital                     252,941,141      250,567,774
   Accumulated deficit                           (129,431,355)    (130,014,061)
                                                 -------------    -------------

   Total stockholders' equity                      123,924,277      120,962,164
                                                 -------------    -------------

Total liabilities and stockholders' equity       $ 135,791,914    $ 130,252,250
                                                 =============    =============
*Condensed from audited financial statements.

The accompanying notes are an integral part of these unaudited consolidated
condensed financial statements.


                                       2
<PAGE>


                          ENZON, INC. AND SUBSIDIARIES
                 CONSOLIDATED CONDENSED STATEMENTS OF OPERATIONS
                 Three Months Ended September 30, 2000 and 1999
                                   (Unaudited)

                                                        Three months ended
                                                    September 30,  September 30,
                                                        2000           1999
                                                    -----------    -----------
Revenues:
  Sales and royalties                               $ 4,947,268    $ 2,870,135
  Contract revenue                                      226,346         43,678
                                                    -----------    -----------
     Total revenues                                   5,173,614      2,913,813
                                                    -----------    -----------
Costs and expenses:
    Cost of sales                                     1,001,188      1,178,561
    Research and development expenses                 2,636,597      1,657,283
    Selling, general and administrative expenses      3,074,227      2,325,971
                                                    -----------    -----------
     Total costs and expenses:                        6,712,012      5,161,815
                                                    -----------    -----------
        Operating (loss)                             (1,538,398)    (2,248,002)
                                                    -----------    -----------

Other income (expense):
    Interest and dividend income                      2,109,213        300,497
    Interest expense                                         --         (2,958)
    Other                                                11,891             --
                                                    -----------    -----------
                                                      2,121,104        297,539
                                                    -----------    -----------
    Net income (loss)                               $   582,706    ($1,950,463)
                                                    ===========    ===========
Basic earnings (loss) per common share              $      0.01    ($     0.05)
                                                    ===========    ===========
Diluted earnings (loss) per common share            $      0.01    ($     0.05)
                                                    ===========    ===========

The  accompanying  notes are an integral  part of these  unaudited  consolidated
condensed financial statements.


                                       3
<PAGE>


                          ENZON, INC. AND SUBSIDIARIES
                 CONSOLIDATED CONDENSED STATEMENTS OF CASH FLOWS
                 Three Months Ended September 30, 2000 and 1999
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                                 Three Months Ended
                                                          September 30,   September 30,
                                                              2000            1999
                                                          ------------    ------------
<S>                                                       <C>             <C>
Cash flows from operating activities:
  Net Income (loss)                                       $    582,706    ($ 1,950,463)
  Adjustment for depreciation and amortization                 130,659         124,512
  Non-cash expense for issuance of common stock,
    stock options, and warrants                                  --             70,022
  Decrease in accrued rent                                      (6,619)         (6,619)
  Increase in royalty advance - Aventis                          --              5,219
  Changes in assets and liabilities                             41,985         554,645
                                                          ------------    ------------
    Net cash provided by (used in) operating activities        748,731      (1,202,684)
                                                          ------------    ------------

Cash flows from investing activities:
 Capital expenditures                                         (127,234)        (69,018)
 Proceeds from sale of long-term investment                     19,600           --
 Maturities of investments                                   5,500,000           --
 Increase in short-term investments                        (19,151,383)          --
 Decrease in long-term investments                           5,950,859           --
                                                          ------------    ------------
   Net cash used in investing activities                    (7,808,158)        (69,018)
                                                          ------------    ------------

Cash flows from financing activities:
Proceeds from issuance of common stock,
    preferred stock, and warrants                            2,379,407       1,233,390
                                                          ------------    ------------
    Net cash provided by financing activities                2,379,407       1,233,390
                                                          ------------    ------------


    Net decrease in cash and cash equivalents               (4,680,020)        (38,312)

Cash and cash equivalents at beginning of period            31,935,410      24,673,636
                                                          ------------    ------------

Cash and cash equivalents at end of period                $ 27,255,390    $ 24,635,324
                                                          ============    ============
</TABLE>


The accompanying notes are an integral part of these consolidated financial
statements.


                                       4
<PAGE>


                          ENZON, INC. AND SUBSIDIARIES
              Notes To Consolidated Condensed Financial Statements
                                   (Unaudited)


(1)  Organization and Basis of Presentation

     The  unaudited   consolidated  condensed  financial  statements  have  been
prepared  from the  books  and  records  of  Enzon,  Inc.  and  subsidiaries  in
accordance with generally accepted  accounting  principles for interim financial
information.  Accordingly,  they  do not  include  all of  the  information  and
footnotes  required by generally  accepted  accounting  principles  for complete
financial statements. In the opinion of management,  all adjustments (consisting
only of  normal  and  recurring  adjustments)  considered  necessary  for a fair
presentation have been included.  Interim results are not necessarily indicative
of the results that may be expected for the year.

(2)  Earnings (loss) Per Common Share

         Basic  earnings  (loss) per common  share is based on the net  earnings
(loss) for the relevant  period,  adjusted for cumulative  undeclared  preferred
stock  dividends of $4,000 and $54,000 for the three months ended  September 30,
2000 and 1999  respectively,  divided by the weighted  average  number of shares
issued and outstanding during the periods. Diluted earnings per common share for
the three months ended  September 30, 2000 is based on net income,  adjusted for
cumulative  undeclared  preferred stock dividends of $4,000 for the three months
ended  September  30,  2000,  divided by the weighted  average  number of common
shares issued and outstanding during the period, plus the exercise or conversion
of all dilutive  potential  common shares.  Due to the net loss recorded for the
three  months  ended  September  30, 1999,  the  exercise or  conversion  of all
dilutive  potential  common  shares is not  included for purposes of the diluted
loss per share calculation.  As of September 30, 2000, the Company had 4,753,000
dilutive  potential  common shares  outstanding  that could  potentially  dilute
future diluted earnings per share calculations.

     The  following  represents  the weighted  average  number of common  shares
outstanding  for the three months ended  September 30, 2000 and 1999 used in the
basic and diluted earnings (loss) per common share calculations:

                                                          Three months ended
                                                   September 30,   September 30,
                                                       2000            1999
                                                   -------------   ------------
Weighted average number of
  common shares issued and
  outstanding - basic                              41,101,289       36,650,335

Weighted average shares issued
  upon the exercise of dilutive
  options and warrants based on
  the Treasury Stock Method                        2,557,370             --
                                                   ----------       ----------


Weighted average number of
  common shares issued and
  outstanding and dilutive potential
  common shares - diluted                          43,658,659       36,650,335
                                                   ----------       ----------


                                       5
<PAGE>


                          ENZON, INC. AND SUBSIDIARIES
              Notes To Consolidated Condensed Financial Statements
                                   (Unaudited)


(3)  Inventories

     The  composition  of inventories at September 30, 2000 and June 30, 2000 is
as follows:

                                                  September 30,         June 30,
                                                      2000               2000
                                                  -------------         --------
     Raw materials                                  $122,000             283,000
     Work in process                                 724,000             504,000
     Finished goods                                  109,000             160,000
                                                    --------            --------
                                                    $955,000            $947,000


(4)  Cash Flow Information

     The Company considers all highly liquid securities with original maturities
of three months or less to be cash equivalents. There were no cash payments made
for interest for the three months ended  September  30, 2000.  Cash payments for
interest  were  approximately  $3,000 for the three months ended  September  30,
1999.  There  were no  income  tax  payments  made for the  three  months  ended
September  30,  2000  and  1999.   Due  to  the  Company's  net  operating  loss
carryforwards,  the net earnings  recorded for the three months ended  September
30,  2000,  did not  result  in the  payment  of  income  taxes.  There  were no
conversions of Series A Preferred  Stock during the three months ended September
30, 2000 and 1999.

(5)  Stockholders' Equity

     During the three months ended  September 30, 2000,  93,000 shares of Common
Stock were issued as a result of the exercise of warrants. The exercise price of
and the number of shares  issuable  under these  warrants  were  adjusted  under
standard anti-dilution provisions based upon the Company's issuance of shares of
Common Stock at prices  below the fair market value of the stock,  as defined in
the warrants.

(6)  Non-Qualified Stock Option Plan

     During the three  months  ended  September  30,  2000,  the Company  issued
527,000 stock options at an average exercise price of $45.90 per share under the
Company's  Non-Qualified  Stock Option Plan, as amended,  of which 200,000 stock
options were granted to executive  officers of the Company.  None of the options
granted during the period are exercisable as of September 30, 2000. Of the total
options granted, 310,000 contain accelerated vesting provisions, under which the
vesting and  exercisability  of such shares will accelerate if the closing price
of the  Company's  Common  Stock  exceeds  $100 per  share  for at least  twenty
consecutive  trading days as reported by the Nasdaq National Market. All options
were granted with exercise prices that equaled or exceeded the fair market value
of the underlying stock on the date of grant.


                                       6
<PAGE>


                          ENZON, INC. AND SUBSIDIARIES
         Notes To Consolidated Condensed Financial Statements, Continued
                                   (Unaudited)

(7)  Business Segments

     A single  management  team  that  reports  to the Chief  Executive  Officer
comprehensively manages the Company's business operations.  The Company does not
operate separate lines of business or separate business entities with respect to
any of its approved  products or product  candidates.  In addition,  the Company
does not conduct any operations  outside of the United States.  The Company does
not prepare  discrete  financial  statements  with  respect to separate  product
areas. Accordingly,  the Company does not have separately reportable segments as
defined by Statement of Financial  Accounting  Standards  No. 131,  "Disclosures
about Segments of an Enterprise and Related Information".

(8)  Comprehensive Income (Loss)

     The net income (loss) of $583,000 and ($1,950,000),  recorded for the three
months  ended  September  30,  2000  and  1999,  respectively,  is  equal to the
comprehensive income (loss) for those periods.


                                       7
<PAGE>


Item 2. Management's  Discussion and Analysis of Financial Condition and Results
        of Operations

Information contained herein contains "forward-looking  statements" which can be
identified  by the  use  of  forward-looking  terminology  such  as  "believes,"
"expects,"  "may," "will," "should," or "anticipates" or the negative thereof or
other  variations  thereon  or  comparable  terminology,  or by  discussions  of
strategy.  We  cannot  assure  you  that  the  future  results  covered  by  the
forward-looking  statements will be achieved. The matters set forth in the "Risk
Factors"  section and elsewhere in our Annual Report on Form 10-K for the fiscal
year ended June 30, 2000, which is incorporated herein by reference,  constitute
cautionary  statements  identifying  important  factors  with  respect  to  such
forward-looking  statements,  including  certain risks and  uncertainties,  that
could cause actual results to vary materially from the future results  indicated
in such  forward-looking  statements.  Other  factors  could also  cause  actual
results  to  vary  materially   from  the  future  results   indicated  in  such
forward-looking statements.

Results of Operations

Three months ended September 30, 2000 vs. Three months ended September 30, 1999

     Revenues.  Revenues for the three months ended September 30, 2000 increased
by 78% to $5,174,000, as compared to $2,914,000 for the same period in the prior
year.  The  components  of  revenues  are sales,  which  consist of sales of our
products and  royalties  earned on sales of approved  products  that utilize our
PEG-technology,  and contract revenues.  Sales and royalties were $4,947,000 for
the three months ended  September 30, 2000,  as compared to  $2,870,000  for the
same period in the prior year.  The  increase  was  primarily  due to  increased
ONCASPAR sales. The increase in ONCASPAR sales was due to the lifting of some of
the FDA  distribution  restrictions  that were in place  during the prior  year.
These  distribution   restrictions  were  related  to  a  previously   disclosed
manufacturing problem and resulted in prior year sales being significantly lower
than in the current quarter. During October 2000, the FDA gave final approval to
manufacturing  changes  which we had  proposed  to correct  these  manufacturing
problems  and  removed  all  previously   imposed   distribution   and  labeling
restrictions.  This will allow for the  resumption  of normal  distribution  and
labeling  of this  product by our  marketing  partner,  Aventis  Pharmaceuticals
(formerly Rhone-Poulenc Rorer Pharmaceuticals,  Inc.), which is expected to take
place in the first half of calendar 2001. We expect lower revenues from ONCASPAR
in future  quarters  when Aventis  resumes  distribution  of the product and our
revenue  stream  reverts back to a 27.5%  royalty  rate on net sales.  Increased
ADAGEN  sales,  as well  as  royalties  earned  on  sales  of  PEG-INTRON,  also
contributed to the increase in sales for the quarter.  ADAGEN sales increased by
21% over the prior year as a result of an increase in patients  receiving ADAGEN
treatment.  Sales of ADAGEN for the three  months ended  September  30, 2000 and
1999 were $3,319,000 and $2,746,000 respectively.

     We expect sales of ADAGEN to increase at rates comparable to those achieved
during the last two years as  additional  patients are treated.  PEG-INTRON  was
approved by the European Union in May 2000 and was launched in several  European
countries throughout the quarter.  Additional launches of PEG-INTRON are ongoing
and expected to occur throughout the remaining  EU-Member States in the upcoming
months.  To  date,  PEG-INTRON  has  been  launched  in the  following  European
countries:  Austria,  Finland, France, Germany,  Portugal, Sweden and the United
Kingdom.   PEG-INTRON  is  a  modified  form  of  Schering-Plough's   INTRON(R)A
(interferon alfa-2b, recombinant) that was developed using our PEG technology to
have   longer-acting   properties.    Under   our   licensing   agreement   with
Schering-Plough,  we are entitled to royalties on worldwide  sales of PEG-INTRON
and milestone payments.

     During the three months ended  September  30, 2000 and 1999,  we had export
sales of  $1,303,000  and $918,000,  respectively.  Of these  amounts,  sales in
Europe were  $1,161,000 and $773,000 for the quarters  ended  September 30, 2000
and 1999, respectively.

     Cost of Sales.  Cost of sales,  as a percentage of sales,  decreased to 20%
for the three  months ended  September  30, 2000 as compared to 41% for the same
period in 1999. The decrease was due to increased cost of sales incurred  during
the  prior  year's  quarter  related  to  the  previously   disclosed   ONCASPAR
manufacturing


                                       8
<PAGE>


problems and the related  inventory  reserves that  decreased the current year's
cost of sales.

     Research and Development.  Research and development  expenses for the three
months ended  September  30, 2000  increased by 59% to $2,637,000 as compared to
$1,657,000  for the same  period  in 1999.  The  increase  is  primarily  due to
increased   expenses  related  to  the  ongoing  Phase  I  clinical  trials  for
PROTHECAN(TM),  as well as other PEG  products in  preclinical  development.  We
currently plan to file an IND on another PEG anti-cancer compound before the end
of calendar 2000. Research and development  expenses are expected to continue to
increase significantly as PROTHECAN moves into Phase II clinical trials in early
2001 and additional compounds enter and progress through clinical trials.

     Selling, General and Administrative Expenses. Selling, general and
administrative expenses for the three months ended September 30, 2000, increased
by 32% to $3,074,000, as compared to $2,326,000 for the same period in 1999. The
increase was due primarily to an increase in legal fees related to litigation,
increased patent filing and defense costs.

     Other  Income/Expense.  Other  income/expense  increased to  $2,121,000  as
compared to $298,000 for the prior year.  The increase  was  attributable  to an
increase in interest income due to an increase in interest bearing investments.

Liquidity and Capital Resources

     Our cash reserves,  including cash and interest  bearing  investments as of
September 30, 2000 were  $121,434,000,  as compared to  $118,413,000 at June 30,
2000.  We  invest  our  excess  cash in a  portfolio  of  high-grade  marketable
securities and United States government-backed securities.

     Our license  agreement with Aventis for ONCASPAR  provided for a payment of
$3,500,000 in advance  royalties which we received from Aventis in January 1995.
Royalties due under this agreement will be offset against an original  credit of
$5,970,000,  which represents the royalty advance plus  reimbursement of certain
amounts due Aventis under a prior  agreement and interest  expense,  before cash
payments  will be made under the  agreement.  The royalty  advance is shown as a
long-term liability,  with the corresponding current portion included in accrued
expenses on the  consolidated  balance sheets and to be reduced as royalties are
recognized  under the  agreement.  Through  September  30, 2000, an aggregate of
$4,313,000 in royalties  payable by Aventis has been offset against the original
credit.

     As of September 30, 2000,  1,043,000 shares of our Series A preferred stock
had been converted into 3,325,000 shares of Common Stock.  Accrued  dividends on
the  converted  Series A preferred  stock in the  aggregate of  $3,770,000  were
settled by the issuance of 235,000  shares of common stock and cash  payments of
$1,947,000.  As of September 30, 2000,  there were accrued and unpaid  dividends
totaling  $148,000  on the 7,000  shares of Series A preferred  stock  currently
outstanding.  These  dividends are payable in cash or common stock at our option
and accrue on the  outstanding  Series A preferred  stock at the rate of $14,000
per year.

     To date,  our sources of cash have been the  proceeds  from the sale of our
stock through public and private  placements,  sales of, and royalties earned on
sales of, ADAGEN,  ONCASPAR and  PEG-INTRON,  sales of our products for research
purposes,  contract  research  and  development  fees,  technology  transfer and
license fees and royalty  advances.  Our current  sources of  liquidity  are our
cash, cash equivalents and investments and interest earned on such cash reserves
and investments,  sales of, and royalties  earned on sales of, ADAGEN,  ONCASPAR
and  PEG-INTRON,  sales of our products for research  purposes and license fees.
Based upon our currently planned research and development activities and related
costs and our current  sources of  liquidity,  we  anticipate  our current  cash
reserves will be sufficient to meet our capital and operational requirements for
the foreseeable future.


                                       9
<PAGE>

     We may seek  additional  financing,  such as through  future  offerings  of
equity or debt securities or agreements with  collaborators  with respect to the
development and  commercialization  of products,  to fund future operations.  We
cannot assure you,  however,  that we will be able to obtain additional funds on
acceptable terms, if at all.

Year 2000

     In 1999 we completed a review of our business systems,  including  computer
systems and manufacturing equipment, and queried our customers and vendors as to
their  progress in identifying  and  addressing  problems that their systems may
face in correctly  interrelating  and  processing  date  information in the year
2000. To date, we have not experienced any significant  problems  related to the
year 2000  problem,  either in our  systems  or the  systems  of our  vendors or
customers.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

     The  following  discussion  about our  exposure to market risk of financial
instruments  contains  forward-looking  statements.  Actual  results  may differ
materially from those described.

     Our holdings of financial instruments are comprised of debt securities, and
time  deposits.  All such  instruments  are  classified  as  securities  held to
maturity.  We do not invest in portfolio equity securities or commodities or use
financial  derivatives  for  trading  purposes.   Our  debt  security  portfolio
represents funds held temporarily pending use in our business and operations. We
manage these funds accordingly.  We seek reasonable assuredness of the safety of
principal  and market  liquidity by  investing in rated fixed income  securities
while at the same time seeking to achieve a favorable rate of return. Our market
risk exposure consists principally of exposure to changes in interest rates. Our
holdings  are also  exposed to the risks of  changes  in the  credit  quality of
issuers.  We typically invest the majority of our investments in the shorter-end
of the maturity spectrum,  and at September 30, 2000 all of our holdings were in
instruments maturing in two and a half years or less.

The table below  presents the  principal  amounts and related  weighted  average
interest rates by year of maturity for our investment  portfolio as of September
30, 2000.


<TABLE>
<CAPTION>

                                  2001            2002            2003             Total         Fair Value
<S>                             <C>             <C>             <C>              <C>             <C>
  Fixed Rate                    26,573,000      62,152,000          --           88,725,000       88,975,000
  Average Interest Rate              6.29%           6.69%          --                6.41%             --
  Variable Rate                       --         4,997,000      10,007,000       15,004,000       15,034,000
  Average Interest Rate               --             6.37%           6.44%            6.56%             --
                               ------------    ------------    ------------    --------------    ------------
                                26,573,000      67,149,000      10,007,000      103,729,000      104,009,000
                               ============    ============    ============    ==============    ============
</TABLE>


                                       10
<PAGE>


PART II OTHER INFORMATION

Item 2. Changes in Securities

     In September 2000, the Company issued 31,243 shares of unregistered Common
Stock for aggregate consideration of $186,750. These shares were issued upon the
exercise of common stock warrants. These warrants were issued in connection with
our March 1996 private placement. The foregoing transaction was consummated
pursuant to an exemption from registration provided by Section 4(2) of the
Securities Act of 1933, as amended.

     In September 2000, the Company issued 62,147 shares of unregistered Common
Stock. These shares were issued upon the cashless exercise of common stock
warrants. These warrants were issued as consideration for consulting services
rendered. The total value of the shares used to pay the exercise price of these
warrants was $418,757. The foregoing transaction was consummated pursuant to an
exemption from registration provided by Section 4(2) of the Securities Act of
1933, as amended.


Item 5. Other Information

     In September 2000, we filed a patent infringement lawsuit in Federal
District Court in New Jersey against Hoffmann-LaRoche, Inc. and Roche
Laboratories, Inc. for infringement of Enzon's U.S. Patent 6,113,906. This
patent, which has composition of matter claims directed to "branched PEG", a
unique form of Enzon's high-molecular-weight pegylation technology, was issued
to Enzon by the U.S. Patent and Trademark Office on September 5, 2000.


                                       11
<PAGE>

Item 6. Exhibits and Reports on Form 8-K

(a) Exhibits (numbered in accordance with Item 601 of Regulation S-K).

<TABLE>
<CAPTION>
                                                                                     Page Number
                                                                                         or
Exhibit                                                                             Incorporation
Number       Description                                                            By Reference
------       -----------                                                            -------------
<S>           <C>                                                                        <C>
   3(i)      Certificate of Incorporation as amended                                             ~~
  3(ii)      By laws, as amended                                                             *(4.2)
  3(iv)      Amendment to Certificate of Incorporation dated January 5, 1998                ##3(iv)
   10.1      Form of Change of Control Agreements dated as of January 20, 1995
             entered into with the Company's Executive Officers                           ###(10.2)
   10.2      Lease - 300-C Corporate Court, South Plainfield, New Jersey                  ***(10.3)
   10.4      Lease Termination Agreement dated March 31, 1995 for
             20 Kingsbridge Road and 40 Kingsbridge Road, Piscataway,
             New Jersey                                                                   ###(10.6)
   10.5      Option Agreement dated April 1, 1995 regarding 20 Kingsbridge
             Road, Piscataway, New Jersey                                                 ###(10.7)
   10.6      Form of Lease - 40 Cragwood Road, South Plainfield, New Jersey              ****(10.9)
   10.7      Lease 300A-B Corporate Court, South Plainfield, New Jersey                   ++(10.10)
   10.8      Stock Purchase Agreement dated March 5, 1987 between the
             Company  and Eastman Kodak Company                                          ****(10.7)
   10.9      Amendment dated June 19, 1989 to Stock Purchase Agreement
             between the Company and Eastman Kodak Company                                **(10.10)
  10.10      Form of Stock Purchase Agreement between the Company
             and the purchasers of the Series A Cumulative
             Convertible Preferred Stock                                                   +(10.11)
  10.11      Amendment to License Agreement and Revised License Agreement
             Between the Company and RCT dated April 25, 1985                             +++(10.5)
  10.12      Amendment dated as of May 3, 1989 to Revised License Agreement
             Dated April 25, 1985 between the Company and Research
             Corporation                                                                  **(10.14)
  10.13      License Agreement dated September 7, 1989 between the Company
             and Research Corporation Technologies, Inc.                                  **(10.15)
  10.14      Master Lease Agreement and Purchase Leaseback Agreement dated
             October 28, 1994 between the Company and Comdisco, Inc.                       #(10.16)
  10.15      Employment Agreement with Peter G. Tombros dated as of
             August 10, 2000                                                              //(10.15)
  10.16      Stock Purchase Agreement dated as of June 30, 1995                            ~(10.16)
  10.17      Securities Purchase Agreement dated as of January 31, 1996                    ~(10.17)
  10.18      Registration Rights Agreements dated as of January 31, 1996                   ~(10.18)
  10.19      Warrants dated as of February 7, 1996 and issued pursuant to the
             Securities Purchase Agreement dated as of January 31, 1996                    ~(10.19)
  10.20      Securities Purchase Agreement dated as of March 15, 1996                     ~~(10.20)
  10.21      Registration Rights Agreement dated as of March 15, 1996                     ~~(10.21)
  10.22      Warrant dated as of March 15, 1996 and issued pursuant to the
             Securities Purchase Agreement dated as of March 15, 1996                    ~~ (10.22)
  10.23      Amendment dated March 25, 1994 to License Agreement dated
             September 7, 1989 between the Company and Research
             Corporation  Technologies, Inc.                                             ~~~(10.23)

                                       12
</TABLE>

<PAGE>
<TABLE>
<CAPTION>
                                                                                     Page Number
                                                                                         or
Exhibit                                                                             Incorporation
Number       Description                                                            By Reference
------       -----------                                                            -------------
<S>           <C>                                                                        <C>
  10.24      Independent Directors' Stock Plan                                           ~~~(10.24)
  10.25      Stock Exchange Agreement dated February 28, 1997, by and between
             the Company and GFL Performance Fund Ltd                                      ^(10.25)
  10.26      Agreement Regarding Registration Rights Under Registration Rights
             Agreement dated March 10, 1997, by and between the Company
             and Clearwater Fund IV LLC                                                    ^(10.26)
  10.27      Common Stock Purchase Agreement dated June 25, 1998                          ^^^(10.27)
  10.28      Placement Agent Agreement dated June 25, 1998 with SBC Warburg
             Dillon Read, Inc.                                                          ^^^^(10.28)
  10.29      Underwriting Agreement dated March 20,2000 with Morgan
             Stanley & Co. Inc., CIBC World Markets Corp., and SG
             Cowen Securities Corporation                                                  /(10.29)
   27.0      Financial Data Schedule
</TABLE>


   *    Filed   herewith

   *    Previously filed as an exhibit to the Company's  Registration  Statement
        on Form S-2 (File No.  33-34874)  and  incorporated  herein by reference
        thereto.

  **    Previously filed as exhibits to the Company's Annual Report on Form 10-K
        for the  fiscal  year  ended June 30,  1989 and  incorporated  herein by
        reference thereto.

 ***    Previously filed as an exhibit to the Company's  Registration  Statement
        on Form S-18 (File No. 2-88240-NY) and incorporated  herein by reference
        thereto.

****    Previously filed as exhibits to the Company's  Registration Statement on
        Form S-1 (File No.  2-96279) filed with the Commission and  incorporated
        herein by reference thereto.

   +    Previously filed as an exhibit to the Company's  Registration  Statement
        on  Form  S-1  (File  No.   33-39391)  filed  with  the  Commission  and
        incorporated herein by reference thereto.

  ++    Previously  filed as an exhibit to the  Company's  Annual Report on Form
        10-K for the fiscal year ended June 30, 1993 and incorporated  herein by
        reference thereto.

 +++    Previously  filed as an exhibit to the  Company's  Annual Report on Form
        10-K for the fiscal year ended June 30, 1985 and incorporated  herein by
        reference thereto.

   #    Previously filed as an exhibit to the Company's Quarterly Report on Form
        10-Q for the quarter ended December 31, 1994 and incorporated  herein by
        reference thereto.

  ##    Previously filed as an exhibit to the Company's Quarterly Report on Form
        10-Q for the quarter ended December 31, 1997 and incorporated  herein by
        reference thereto.

 ###    Previously filed as an exhibit to the Company's Quarterly Report on Form
        10-Q for the quarter  ended March 31,  1995 and  incorporated  herein by
        reference thereto.

   ~    Previously filed as an exhibit to the Company's Quarterly Report on Form
        10-Q for the quarter ended December 31, 1995 and incorporated  herein by
        reference thereto.

  ~~    Previously filed as an exhibit to the Company's Quarterly Report on Form
        10-Q for the quarter  ended March 31,  1996 and  incorporated  herein by
        reference thereto.


                                       13
<PAGE>


 ~~~    Previously filed as an exhibit to the Company's Quarterly Report on Form
        10-Q for the quarter ended December 31, 1996 and incorporated  herein by
        reference thereto.

   ^    Previously filed as an exhibit to the Company's Quarterly Report on Form
        10-Q for the quarter  ended March 31,  1997 and  incorporated  herein by
        reference thereto.

  ^^    Previously  filed as an exhibit to the  Company's  Annual Report on Form
        10-K for the  year  ended  June 30,  1997  and  incorporated  herein  by
        reference thereto.

 ^^^    Previously filed as an exhibit to the Company's  Registration  Statement
        on  Form  S-3  (File  No.  333-58269)  filed  with  the  Commission  and
        incorporated herein by reference thereto.

^^^^    Previously  filed as an exhibit to the  Company's  Annual Report on Form
        10-K for the  year  ended  June 30,  1998  and  incorporated  herein  by
        reference thereto.

   /    Previously filed as an exhibit to the Company's  Registration  Statement
        on  Form  S-3  (File  No.  333-30818)  filed  with  the  Commission  and
        incorporated herein by reference thereto.

  //    Previously  filed as an exhibit to the  Company's  Annual Report on Form
        10-K for the  year  ended  June 30,  2000  and  incorporated  herein  by
        reference thereto.

(b)  Reports on Form 8-K.

On August 17, 2000,  we filed with the  Commission a Current  Report on Form 8-K
dated August 10, 2000,  reporting that Peter Tombros,  our President and CEO had
signed a new employment agreement.

On September 18, 2000, we filed with the Commission a Current Report on Form 8-K
dated September 5, 2000, related to a lawsuit which we filed in Federal Court in
New Jersey against Hoffmann-LaRoche, Inc. and Roche laboratories, Inc. (Roche)
for infringement of our new U.S. Patent 6,113,906 (`906), by Roche's "PEGASYS,"
a pegylated alpha interferon-2a product.


                                       14

<PAGE>


                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.

                                     ENZON, INC.
                                     -----------
                                     (Registrant)



Date: November 13, 2000              By: /s/ Peter G. Tombros
                                        ---------------------------------
                                     Peter G. Tombros
                                     President and Chief Executive
                                      Officer



                                      By: /s/ Kenneth J. Zuerblis
                                      -----------------------------------
                                      Kenneth J. Zuerblis
                                      Vice President, Finance, Chief Financial
                                       Officer (Principal Financial
                                      and Accounting Officer) and
                                      Corporate Secretary


                                       16


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