ENZON INC
4, 2001-01-08
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[_]  Check box if no longer  subject to Section 16. Form 4 or Form 5 obligations
     may continue. See Instruction 1(b).


(Print or Type Responses)
________________________________________________________________________________
1.   Name and Address of Reporting Person*

     Dixon                            Rosina                 B.

--------------------------------------------------------------------------------
   (Last)                            (First)              (Middle)

     c/o Enzon, Inc.,  20 Kingsbridge Road

--------------------------------------------------------------------------------
                                    (Street)

     Piscataway,                New Jersey                 08854
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   (City)                            (State)                (Zip)
________________________________________________________________________________
2.   Issuer Name and Ticker or Trading Symbol

     Enzon, Inc. (ENZN)

________________________________________________________________________________
3.   I.R.S. Identification Number of Reporting Person, if an entity (Voluntary)


________________________________________________________________________________
4.   Statement for Month/Year

     December 2000

________________________________________________________________________________
5.   If Amendment, Date of Original (Mo/Yr)



________________________________________________________________________________
6.   Relationship of Reporting Person(s) to Issuer
     (Check all applicable)

     [X]  Director                             [_]  10% Owner
     [_]  Officer (give title below)           [_]  Other (specify below)

________________________________________________________________________________
7.   Individual or Joint/Group Filing
     (Check Applicable Line)

     [X]  Form filed by one Reporting Person
     [_]  Form filed by more than one Reporting Person
________________________________________________________________________________


================================================================================
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                 5.             6.
                                                                 4.                              Amount of      Owner-
                                                                 Securities Acquired (A) or      Securities     ship
                                                    3.           Disposed of (D)                 Beneficially   Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Owned at End   Direct    Nature of
                                      2.            Code         -----------------------------   of Month       (D) or    Indirect
1.                                    Transaction   (Instr. 8)                (A)                               Indirect  Beneficial
Title of Security                     Date          ---------       Amount    or     Price       (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)    Code    V                 (D)                and 4)         (Instr.4) (Instr. 4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                                   <C>           <C>    <C>     <C>        <C>   <C>             <C>           <C>     <C>

Common Stock                          9/30/00       A      V        50        A    See footnote 1                 D
------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          12/13/00      G      V       145        D         --                        D
------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          12/15/00      G      V        25        D         --          26,463(2)     D
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                       500(3)     I       By husband
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                       100(3)     I       By son
------------------------------------------------------------------------------------------------------------------------------------

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====================================================================================================================================
Common Stock
</TABLE>


1)   Securities granted by Enzon, Inc. pursuant to the Independent Directors
     Stock Plan as compensation for service as a member of the Board of
     Directors of Enzon, Inc. and qualified under Rule 16b-3(c).

2)   The aggregate number of shares beneficially held directly by Dr. Dixon as
     of July 31, 2000 was previously incorrectly reported as 26,571. The
     aggregate number of shares beneficially held directly by Dr. Dixon as of
     July 31, 2000 was 26,583.

3)   The reporting person disclaims beneficial ownership of these securities,
     and this report shall not be deemed an admission that the reporting person
     is the beneficial owner of such securities for purposes of Section 16 or
     for any other purpose.


Reminder:  Report on a separate line for each class of  securities  beneficially
owned directly or indirectly.

*    If the form is filed by more than one  Reporting  Person,  see  Instruction
     4(b)(v).

Potential Persons who are to respond to the collection of information  contained
in this form are not required to respond unless the form displays a currently
valid OMB control number.


                                                                          (Over)
                                                                 SEC 1474 (7-97)

<PAGE>


FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                                    10.
                                                                                                          9.        Owner-
                                                                                                          Number    ship
                                                                                                          of        Form
                    2.                                                                                    Deriv-    of
                    Conver-                    5.                              7.                         ative     Deriv-   11.
                    sion                       Number of                       Title and Amount           Secur-    ative    Nature
                    or                         Derivative    6.                of Underlying     8.       ities     Secur-   of
                    Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-
                    cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct
                    Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-
1.                  of       action   Code     of (D)        (Month/Day/Year)            Amount  ative    at End    In-      ficial
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner-
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship
Security            Secur-   Day/     -------  ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code  V   (A)   (D)    cisable  Date     Title     Shares  5)       4)        4)       4)
------------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>      <C>      <C>  <C>  <C>   <C>    <C>      <C>      <C>       <C>     <C>      <C>       <C>      <C>


------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------------

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====================================================================================================================================
</TABLE>
Explanation of Responses:



           /s/ Rosina Dixon                                      1/4/01
---------------------------------------------            -----------------------
      **Signature of Reporting Person                             Date


**   Intentional misstatements or omissions of facts constitute Federal Criminal
     Violations.
     See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this form, one of which must be manually signed.
       If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB number.

                                                                          Page 2
                                                                 SEC 1474 (7-97)




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