LIFE TECHNOLOGIES INC
SC 13D/A, 2000-01-28
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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================================================================================


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                                (Amendment No. 8)

                         ------------------------------

                             LIFE TECHNOLOGIES, INC.
                                (Name of Issuer)

COMMON STOCK, $.01 PAR VALUE PER SHARE                      532177201
    (Title of class of securities)                        (CUSIP number)

                            RICHARD A. WEINBERG, ESQ.
                        C/O ISP MANAGEMENT COMPANY, INC.
                                 1361 ALPS ROAD
                             WAYNE, NEW JERSEY 07470
                                 (973) 628-3000
            (Name, address and telephone number of person authorized
                     to receive notices and communications)

                                 WITH A COPY TO:

                             STEPHEN E. JACOBS, ESQ.
                           WEIL, GOTSHAL & MANGES LLP
                                767 FIFTH AVENUE
                          NEW YORK, NEW YORK 10153-0119
                                 (212) 310-8000

                                JANUARY 27, 2000
             (Date of event which requires filing of this statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of ss.ss. 240.13d-1(e), 240.13d-1(f) or 240.13d-(g), check the
following box. [ ]

Note: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See ss. 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purposes of Section 18 of the Securities Exchange Act of
1934 (the "Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act. (However, see the
Notes.)

                         (Continued on following pages)

                              (Page 1 of 25 Pages)


================================================================================
NY2:\870622\03\54104.0016
<PAGE>


- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 2 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON              ISP OPCO HOLDINGS INC.
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            OO
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Delaware
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                            0
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                  3,384,600
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:                       0
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:             3,384,600
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                          3,384,600
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):    13.56%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            CO
- ------------------ -------------------------------------------------------------




<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 3 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             ISP INVESTMENTS INC.
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            WC, OO
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Delaware
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:              2,932,600
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:              452,000
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:         2,932,600
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:         452,000
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                    3,384,600
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):    13.56%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            CO
- ------------------ -------------------------------------------------------------



<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 4 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             ISP IRELAND
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            WC, OO
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Ireland
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:              452,000
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                  0
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:         452,000
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:             0
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                    452,000
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):    1.81%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            CO
- ------------------ -------------------------------------------------------------



<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 5 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON            INTERNATIONAL SPECIALTY
                   S.S. OR I.R.S. IDENTIFICATION NO.   PRODUCTS INC.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            OO
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Delaware
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                    121,670
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                3,384,600
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:               121,670
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:           3,384,600
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                        3,506,270
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):    14.05%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            CO
- ------------------ -------------------------------------------------------------



<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 6 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             BEAR, STEARNS & CO. INC.
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            WC, PF
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            DELAWARE
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                 342,826
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                92,000
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:            342,826
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:           92,000
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                       434,826
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     1.73%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            CO
- ------------------ -------------------------------------------------------------



<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 7 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             FREDERICK R. ADLER
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            PF
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            USA
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                    714,895
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                        0
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:               714,895
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:                   0
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                          714,895
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     2.86%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            OO
- ------------------ -------------------------------------------------------------

<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 8 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON           THE COHEN REVOCABLE TRUST
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            PF
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            California
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:               397,100
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                   0
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:          397,100
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:              0
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                     397,100
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):    1.59%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            OO
- ------------------ -------------------------------------------------------------



<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 9 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             A. CHANG
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            PF
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            USA
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:              135,500
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                  0
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:         135,500
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:             0
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                    135,500
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     0.54%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            IN
- ------------------ -------------------------------------------------------------




<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 10 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON        YORK CAPITAL MANAGEMENT, L.P.
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            WC
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Delaware
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:              78,700
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                 0
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:         78,700
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:            0
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                    78,700
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     0.32%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            PN
- ------------------ -------------------------------------------------------------



<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 11 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             DINAN MANAGEMENT, L.L.C.
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            WC
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            New York
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                    0
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:             78,700
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:               0
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:        78,700
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                     78,700
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     0.32%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            OO
- ------------------ -------------------------------------------------------------

<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 12 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON            JGD MANAGEMENT CORP.
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            AF
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Delaware
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                 23,100
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                    0
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:            23,100
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:               0
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                       23,100
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     0.09%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            CO
- ------------------ -------------------------------------------------------------


<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 13 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             YORK INVESTMENT LIMITED
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            WC
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Bahamas
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                129,600
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:                    0
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:           129,600
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:               0
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                      129,600
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     0.52%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            OO
- ------------------ -------------------------------------------------------------


<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 14 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             DINAN MANAGEMENT
                   S.S. OR I.R.S. IDENTIFICATION NO.    CORPORATION
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            AF
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            Delaware
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                    0
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:            129,600
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:               0
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:       129,600
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                    129,600
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     0.52%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            CO
- ------------------ -------------------------------------------------------------


<PAGE>
- -----------------------------------           ----------------------------------
CUSIP No. 532177201                    13D               Page 15 of 25 Pages
- -----------------------------------           ----------------------------------

- ------------------ -------------------------------------------------------------
        1          NAME OF REPORTING PERSON             JAMES G. DINAN
                   S.S. OR I.R.S. IDENTIFICATION NO.
                   OF ABOVE PERSON

- ------------------ -------------------------------------------------------------
        2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:     (a) [X]
                                                                         (b) [ ]
- ------------------ -------------------------------------------------------------
        3          SEC USE ONLY
- ------------------ -------------------------------------------------------------
        4          SOURCE OF FUNDS:                            AF
- ------------------ -------------------------------------------------------------
        5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
                   PURSUANT TO ITEM 2(d) OR 2(e):                            [_]
- ------------------ -------------------------------------------------------------
        6          CITIZENSHIP OR PLACE OF ORGANIZATION:            USA
- --------------------------------------------------------------------------------
    NUMBER OF           7     SOLE VOTING POWER:                      0
      SHARES
                      ------- --------------------------------------------------
   BENEFICIALLY         8     SHARED VOTING POWER:              231,400
     OWNED BY
                      ------- --------------------------------------------------
       EACH             9     SOLE DISPOSITIVE POWER:                 0
    REPORTING
                      ------- --------------------------------------------------
   PERSON WITH          10    SHARED DISPOSITIVE POWER:         231,400
- ------------------ -------------------------------------------------------------
       11          AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING
                   PERSON:                                      231,400
- ------------------ -------------------------------------------------------------
       12          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
                   CERTAIN SHARES:                                           [_]
- ------------------ -------------------------------------------------------------
       13          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11):     0.93%
- ------------------ -------------------------------------------------------------
       14          TYPE OF REPORTING PERSON:            IN
- ------------------ -------------------------------------------------------------


<PAGE>


           This Amendment No. 8 ("Amendment No. 8") amends the Statement on
Schedule 13D (the "Schedule 13D") filed on November 20, 1998, as amended by
Amendment No. 1 filed on November 30, 1998 ("Amendment No. 1"), Amendment No. 2
filed on December 2, 1998 ("Amendment No. 2"), Amendment No. 3 filed on December
21, 1998 ("Amendment No. 3"), Amendment No. 4 filed on December 24, 1998
("Amendment No. 4"), Amendment No. 5 filed on May 11, 1999 ("Amendment No. 5"),
Amendment No. 6 filed on December 6, 1999 ("Amendment No. 6"), and Amendment No.
7 filed on January 3, 2000 ("Amendment No. 7"), by and on behalf of ISP Opco
Holdings Inc. ("ISP Opco"), ISP Investments Inc. ("ISP Investments"),
International Specialty Products Inc. ("ISP"), ISP Ireland ("ISP Ireland" and,
together with ISP Opco, ISP Investments and ISP, the "ISP Group"), Bear, Stearns
& Co. Inc. ("Bear, Stearns"), Frederick R. Adler ("Adler"), The Cohen Revocable
Trust (the "Cohen Trust"), A. Chang ("Chang"), York Capital Management, L.P.
("York Capital"), Dinan Management, L.L.C. ("Dinan Management"), JGD Management
Corp. ("JGD Management"), York Investment Limited ("York Investment"), Dinan
Management Corporation ("DMC") and James G. Dinan ("JGD") (collectively, the
"Reporting Persons") with respect to their ownership of common stock, par value
$.01 per share (the "Common Stock"), of Life Technologies, Inc. (the "Company").
As indicated in Item 2 below, the Shares formerly owned beneficially by the
Adler Trust are now owned directly and beneficially by Adler. Capitalized terms
used herein and not defined herein have the meanings ascribed thereto in the
Schedule13D, as previously amended.

ITEM 2. IDENTITY AND BACKGROUND

           Adler, a citizen of the United States of America, is primarily
engaged as a venture capitalist. Adler's principal place of business is 1520
South Ocean Blvd., Palm Beach, Florida 33480.

           Adler has not, during the last five years, (i) been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors) or
(ii) been a party to any civil proceeding of a judicial or administrative body
of competent jurisdiction as a result of which Adler was or is subject to a
judgment, decree or final order enjoining the future violations of, or
prohibiting or mandating activities subject to, federal or state securities laws
or finding a violation with respect to such laws.

ITEM 3. SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

           In addition to the 713,395 Shares previously reported by the Adler
Trust that were transferred to Adler for no consideration, Adler has purchased
an aggregate of 1,500 Shares for total consideration (including brokerage
commissions) of $54,093 derived from personal funds.


                                       16
<PAGE>


ITEM 4. PURPOSE OF THE TRANSACTION

           On January 19, 2000, Dexter Corporation offered to purchase all
outstanding shares of the Common Stock for $49 per share in cash in a merger
transaction. The Reporting Persons have rejected such offer.

ITEM 5. INTEREST IN SECURITIES OF THE ISSUER

           As of the close of business on January 27, 2000, the Reporting
Persons beneficially owned (or are deemed, solely for purposes of Rule 13d-3, to
beneficially own), directly or indirectly, an aggregate of 5,417,991 Shares,
representing approximately 21.71% of the Common Stock outstanding (based on
24,957,556 shares of Common Stock believed by the Reporting Persons to be
outstanding as of November 2, 1999).

           Adler has the sole power to vote, direct the voting of, dispose of
and direct the disposition of 714,895 Shares.

           Bear, Stearns has the sole power to vote, direct the voting of,
dispose of and direct the disposition of 340,826 Shares. Bear, Stearns has
shared power to vote, direct the voting of, dispose of and direct the
disposition of 92,000 Shares held in discretionary accounts. Of the 434,526
Shares beneficially owned by Bear, Stearns, only 300,000 Shares that are owned
by Bear, Stearns are subject to the letter agreement, dated as of November 25,
1998 (as amended, modified, supplemented, renewed or extended to the date
hereof, the "Bear Stearns Group Agreement"), between Bear, Stearns and certain
of the Reporting Persons. The remaining 40,826 Shares owned by Bear, Stearns are
held in its market-making account and are not subject to the Bear Stearns Group
Agreement. The 92,000 Shares beneficially owned by Bear, Stearns in
discretionary accounts are also not subject to the Bear Stearns Group Agreement.

           Since the filing of Amendment No. 7, the Reporting Persons effected
transactions in Shares in open market transactions as set forth in Schedule A
hereto.

ITEM 6. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO
        SECURITIES OF THE ISSUER

           On January 27, 2000, Adler and certain of the other Reporting Persons
entered into a Joinder Agreement (the "Joinder Agreement"), pursuant to which
Adler agreed to be bound by, and subject to, all of the covenants, terms and
conditions of each of the Group Agreements previously entered into by certain of
the Reporting Persons other than Adler.

           Except as set forth above, the response of the Reporting Persons to
this Item 6 as previously disclosed in the Schedule 13D, as previously amended,
has not changed.

ITEM 7. MATERIAL TO BE FILED AS EXHIBITS

           Form of Joinder Agreement among Adler and certain of the Reporting
Persons with respect to the Common Stock.

             [The remainder of this page intentionally left blank.]



                                       17
<PAGE>


                                   SIGNATURES

           After reasonable inquiry and to the best of their knowledge and
belief, the undersigned certify that the information set forth in this Statement
is true, complete and correct.

Dated: January 28, 2000

                               ISP OPCO HOLDINGS INC.
                               ISP INVESTMENTS INC.
                               INTERNATIONAL SPECIALTY PRODUCTS INC.

                               By:  /s/ Susan B. Yoss
                                    --------------------------------------------
                                    Susan B. Yoss
                                    Vice President and Treasurer


                               ISP IRELAND

                               By:  /s/ Ueli Marty
                                    --------------------------------------------
                                    Ueli Marty
                                    Director


                               BEAR, STEARNS & CO. INC.

                               By:  /s/ Barry Cohen
                                    --------------------------------------------
                                    Barry Cohen
                                    Senior Managing Director


                               YORK CAPITAL MANAGEMENT, L.P.

                               By: DINAN MANAGEMENT, L.L.C., its General Partner

                                    By: /s/ James G. Dinan
                                        ----------------------------------------
                                        James G. Dinan
                                        President


                               DINAN MANAGEMENT, L.L.C.

                               By:  /s/ James G. Dinan
                                    --------------------------------------------
                                    James G. Dinan
                                    President


                                       18
<PAGE>

                               JGD MANAGEMENT CORP.
                               DINAN MANAGEMENT CORPORATION

                               By:  /s/ James G. Dinan
                                    --------------------------------------------
                                    James G. Dinan
                                    President


                               YORK INVESTMENT LIMITED

                               By:  /s/ Anthony L.M. Inder Reiden
                                    --------------------------------------------
                                    Anthony L.M. Inder Reiden
                                    Director


                               /s/ James G. Dinan
                               -------------------------------------------------
                               James G. Dinan

                               /s/ Frederick R. Alder
                               -------------------------------------------------
                               Frederick R. Alder


                               THE COHEN REVOCABLE TRUST

                               By:  /s/ S. Cohen
                                    --------------------------------------------
                                    S. Cohen
                                    Trustee


                               /s/ A. Chang
                               -------------------------------------------------
                               A. Chang



                                       19
<PAGE>

                                   SCHEDULE A



           The following schedule sets forth information with respect to each
purchase of Shares which was effectuated by the Reporting Persons since the
filing of Amendment No. 6. All transactions were effectuated in the open market
through a broker.

                             ISP OPCO HOLDINGS INC.
                              ---------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                   ISP INVESTMENTS INC. (directly and through
                          ISP Investment Grantor Trust)
                   ------------------------------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                      INTERNATIONAL SPECIALTY PRODUCTS INC.
                      -------------------------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                                   ISP IRELAND
                                   -----------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                                       20
<PAGE>


                            BEAR, STEARNS & CO. INC.
                            ------------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

    1/10/00                        (200)                           43 1/2
    1/13/00                        (500)                           44 1/2
    1/18/00                        (500)                           45 3/8
    1/18/00                        (500)                           45


                               FREDERICK R. ADLER
                               ------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                            THE COHEN REVOCABLE TRUST
                            -------------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                                    A. CHANG
                                    --------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                          YORK CAPITAL MANAGEMENT, L.P.
                          -----------------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                                       21
<PAGE>



                            DINAN MANAGEMENT, L.L.C.
                            ------------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                             YORK INVESTMENT LIMITED
                             -----------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None



                              JGD MANAGEMENT CORP.
                              --------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                          DINAN MANAGEMENT CORPORATION
                          ----------------------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None


                                 JAMES G. DINAN
                                 --------------

                                  Number of
      Date                  Shares Purchased (Sold)             Price Per Share
      ----                  -----------------------             ---------------

                                      None



                                       22
<PAGE>




                             EXHIBIT INDEX

Exhibit No.                  Document                         Page No.
- -----------                  --------                         --------
     1          Form of Joinder Agreement among
                Adler and certain of the Reporting
                Persons with respect to the Common
                Stock.








                                       23


                                                                       EXHIBIT 1


                              JOINDER AGREEMENT TO

                           GROUP AGREEMENTS REGARDING
                              COMMON STOCK OF LIFE
                               TECHNOLOGIES, INC.

           On January 26, 2000, the Frederick R. Adler Trust (the "Trust")
transferred (the "Transfer") beneficial ownership of all shares of common stock,
par value $.01 per share (the "Common Stock"), of Life Technologies, Inc.
("LTI") held by the Trust to Frederick R. Adler.

           By his execution and delivery of the attached signature page, Adler
hereby:

           (i) agrees to become a party to each of the Agreements, dated as of
           November 25, 1998, December 1, 1998, and December 18, 1998,
           respectively (each as amended on May 10, 1999 and December 3, 1999),
           among International Specialty Products Inc. and each of the Investors
           party thereto (collectively, the "Group Agreements"), and shall be
           fully bound by, and subject to, all of the covenants, terms and
           conditions of each of the Group Agreements as though an original
           party thereto and shall be deemed an Investor, as such term is
           defined in each of the Group Agreements, for all purposes thereof;
           and

           (ii) authorizes the attached signature page to be attached to and
           made part of each of the Group Agreements; and

           (iii) authorizes this Joinder Agreement to be filed as an exhibit to
           a Schedule 13D filing with the Securities and Exchange Commission
           with respect to the Group Agreements and the Common Stock.

           In addition, by execution of the attached signature page, each of the
undersigned consents to the Transfer.

           This Joinder Agreement may be executed in any number of counterparts,
each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

                         [Signatures on Following Page]


<PAGE>


           IN WITNESS WHEREOF, each of the undersigned has caused this Joinder
Agreement to be executed as of the 27th day of January, 2000.



                                           /s/ Frederick R. Adler
                                           ----------------------
                                           Frederick R. Adler
Agreed to and accepted this
27th day of January, 2000

INTERNATIONAL SPECIALTY                    YORK CAPITAL MANAGEMENT, L.P.,
PRODUCTS INC.                              by Dinan Management, L.L.C., its
                                           General Partner

By: /s/ Kumar Shah
    -----------------------------
    Name:  Kumar Shah                      By: /s/ James G. Dinan
    Title: Senior Vice President              -----------------------------
                                              Name: James G. Dinan
                                              Title: Senior Managing Member

THE COHEN REVOCABLE TRUST
                                           JGD MANAGEMENT CORP.

By: /s/ S. Cohen
    -----------------------------
    Name:  S. Cohen                        By: /s/ James G. Dinan
    Title: Trustee                            -----------------------------
                                              Name: James G. Dinan
                                              Title: President

BEAR, STEARNS & CO. INC.
                                           YORK INVESTMENT LIMITED

By: /s/ Barry Cohen
   --------------------------------
    Name: Barry Cohen                      By: /s/ Anthony L.M. Inder Reiden
    Title: Senior Managing Director           -------------------------------
                                              Name: Anthony L.M. Inder Reiden
                                              Title: Director


/s/ A. Chang
- -----------------------------
A. Chang



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