CORTECH INC
PREC14A, 1998-07-24
PHARMACEUTICAL PREPARATIONS
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                           SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant [x]
Filed by a party other than the Registrant [ ]

Check the appropriate box:

[x]      Preliminary Proxy Statement
[ ]  Confidential,  for  Use  of the  Commission  Only  (as  permitted  by  Rule
14a-6(e)(2)) [ ] Definitive Proxy Statement [ ] Definitive  Additional Materials
[ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                                 Cortech, Inc.
             (Name of Registrant as Specified In Its Charter)

                                      N/A
   (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[x]    No fee required

[ ]    Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

         1) Title of each class of securities to which transaction applies:



         2) Aggregate number of securities to which transaction applies:



         3)       Per  unit  price  or other  underlying  value  of  transaction
                  computed  pursuant  to  Exchange  Act Rule 0-11 (set forth the
                  amount on which the filing fee is calculated  and state how it
                  was determined):



         4) Proposed maximum aggregate value of transaction:



         5) Total fee paid:


[ ]      Fee paid previously with preliminary materials.

[ ]      Check box if any part of the fee is offset as  provided  by  Exchange
         Act Rule  0-11(a)(2)  and identify the filing for which the  offsetting
         fee was paid  previously.  Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

         1)       Amount Previously Paid:

         2)       Form, Schedule or Registration Statement No.:

         3)       Filing Party:

         4)       Date Filed:

<PAGE>


                                Cortech, Inc.
                          6850 N. Broadway, Suite G
                            Denver, Colorado 80221
                               (303) 650-1200

                                                                August __, 1998


Dear Stockholder:

         You are cordially  invited to attend Cortech,  Inc.'s Annual Meeting of
Stockholders,  which will begin at 9:00 a.m.  local time,  Friday,  September 4,
1998 at The Renaissance Hotel, 3801 Quebec Street, Denver, Colorado.

         Stockholders will vote on the proposals  detailed in the attached proxy
statement,  and  we  will  present  a  brief  status  report  on  the  Company's
operations.

         Regardless of your plans to join us on September  4th, we hope you will
sign, date and return your WHITE-STRIPED  proxy card in the envelope provided at
your earliest convenience. We look forward to your reply.


                                                             Sincerely yours,



                                                             Bert Fingerhut
                                                             Chairman

<PAGE>


                                 CORTECH, INC.

                                 ------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                         TO BE HELD SEPTEMBER 4, 1998
                                 ------------


        NOTICE IS HEREBY  GIVEN  that the  Annual  Meeting  of  Stockholders  of
Cortech, Inc., a Delaware corporation ("Cortech" or the "Company"), will be held
on Friday,  September 4, 1998 at 9:00 a.m. local time at The Renaissance  Hotel,
3801 Quebec Street, Denver, Colorado for the following purposes:

        1.      To elect  one Class I  director  to hold  office  until the 2001
                annual meeting of stockholders or until his successor is elected
                and has qualified and, if the stockholder  proposal set forth in
                item 4 below  is  approved,  to  elect  two  additional  Class I
                directors  and one  Class III  director  to hold  office  until,
                respectively,  the 2001 and 2000 annual meeting of  stockholders
                or until their successors are elected and have qualified.

       2.       To adopt and approve an amendment to the  Company's  Certificate
                of Incorporation which provides for a one-for-four reverse stock
                split of outstanding Cortech common stock.

       3.       To adopt and approve an amendment to the  Company's  Certificate
                of  Incorporation,  which  provides  that the Board of Directors
                shall fix the number of directors.

       4.       To consider and act upon a  stockholder  proposal  concerning an
                amendment  to the  Company's  By-laws to increase  the number of
                directors, which proposal is opposed by the Board of Directors.

       5.       To ratify the  selection of Arthur  Andersen LLP as  independent
                auditors of the Company for its fiscal year ending  December 31,
                1998.

       6.       To transact such other  business as may properly come before the
                meeting or any adjournment or postponement thereof.

        The  foregoing  items of business are more fully  described in the Proxy
Statement accompanying this Notice.

        The Board of Directors  has fixed the close of business on July 10, 1998
as the record date for the  determination of stockholders  entitled to notice of
and to  vote at this  Annual  Meeting  and at any  adjournment  or  postponement
thereof.

                                            By Order of the Board of Directors,



                                            Bert Fingerhut
                                            Chairman

Denver, Colorado
August __, 1998


        ALL STOCKHOLDERS ARE CORDIALLY  INVITED TO ATTEND THE MEETING IN PERSON.
WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN AND
RETURN THE ENCLOSED WHITE-STRIPED PROXY CARD AS PROMPTLY AS POSSIBLE IN ORDER TO
ENSURE YOUR  REPRESENTATION AT THE MEETING.  A RETURN ENVELOPE (WHICH IS POSTAGE
PREPAID IF MAILED IN THE UNITED  STATES) IS ENCLOSED FOR THAT  PURPOSE.  EVEN IF
YOU HAVE  GIVEN  YOUR  PROXY,  YOU MAY STILL  VOTE IN PERSON IF YOU  ATTEND  THE
MEETING.  PLEASE  NOTE,  HOWEVER,  THAT IF YOUR  SHARES  ARE HELD OF RECORD BY A
BROKER,  BANK OR OTHER  NOMINEE  AND YOU WISH TO VOTE AT THE  MEETING,  YOU MUST
OBTAIN FROM THE RECORD HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE>



PRELIMINARY COPY                    SUBJECT TO COMPLETION, DATED JULY 24, 1998


                                CORTECH, INC.
                                ------------

                               PROXY STATEMENT
                                ------------

General

        The  enclosed  proxy is solicited on behalf of the Board of Directors of
Cortech, Inc., a Delaware corporation  ("Cortech" or the "Company"),  for use at
the  Annual  Meeting  of  Stockholders  (the  "Annual  Meeting")  to be  held on
September 4, 1998 at 9:00 a.m. local time, or at any adjournment or postponement
thereof,  for the purposes set forth  herein and in the  accompanying  Notice of
Annual Meeting.  The Annual Meeting will be held at The Renaissance  Hotel, 3801
Quebec  Street,  Denver,  Colorado.  The  Company  intends  to mail  this  proxy
statement  and  accompanying  proxy  card on or about  August 10,  1998,  to all
stockholders entitled to vote at the Annual Meeting.

         You may have  already  received  an  opposition  proxy  statement  (the
"Opposition  Proxy")  from  Asset  Value Fund  Limited  Partnership  ("AVF"),  a
dissident  stockholder that is attempting a hostile takeover of the Company.  In
connection with its hostile  takeover  attempts,  AVF is soliciting  proxies to,
among other things, amend the Company's Bylaws to increase the size of the Board
from four to seven members and,  subject to the approval of such  amendment,  to
elect  its  four  nominees  to the  Board  (to fill  the one  vacancy  currently
available plus the three  vacancies  created by the Bylaw  amendment).  In other
words,  AVF is seeking  to seize  control of the  Company by  circumventing  the
classified structure of the Board and electing a majority of the directors.

         AVF  is  an  investment  vehicle  led  by  Paul  Koether,  a  notorious
greenmailer with a documented  history of purchasing  short-term  positions in a
public company, threatening and waging costly and divisive proxy contests under
the ruse of  protecting  stockholder  interests  and then  selling  out when his
personal enrichment goals are achieved.  The Board of Directors urges you not to
support AVF's hostile attempt to take over the Company,  but to carefully review
the information  contained in this proxy statement and sign, date and return the
BLUE proxy card today in the enclosed, postage pre-paid envelope.

Voting Rights and Outstanding Shares

        Only  holders of record of Common Stock at the close of business on July
10,  1998 (the  "Record  Date") will be entitled to notice of and to vote at the
Annual  Meeting.  At the close of  business  on the Record  Date the Company had
outstanding and entitled to vote 18,523,918  shares of Common Stock. Each holder
of record of Common  Stock on the Record  Date will be  entitled to one vote for
each share held on all matters to be voted upon at the Annual Meeting.

        Under the  By-laws  of the  Company,  a quorum  for the  transaction  of
business is constituted by the presence,  in person or by proxy,  of the holders
of a majority of the stock of the Company issued and outstanding and entitled to
vote at the meeting. A plurality of the votes of the shares present and entitled
to vote at the Annual  Meeting is required to approve the  election of directors
in Proposal 1. The  affirmative  vote of holders of a majority of the  Company's
issued and outstanding shares entitled to vote at the Annual Meeting is required
to approve  each of Proposals 2 and 3 and the  affirmative  vote of holders of a
majority of the shares present in person or by proxy and entitled to vote on the
matter at the Annual Meeting is required to approve each of Proposals 4 and 5.

        All votes will be tabulated by the  inspector of election  appointed for
the meeting,  who will  separately  tabulate  affirmative  and  negative  votes,
abstentions  and  broker  non-votes.  Abstentions  will be counted  towards  the
tabulation  of votes cast on proposals  presented to the  stockholders  and will
have the same effect as negative votes.  Broker  non-votes are counted towards a
quorum, but are not counted for any purpose in determining  whether a matter has
been approved.

<PAGE>

Revocability of Proxies

        Any person giving a proxy in connection  with the Annual Meeting has the
power to revoke such proxy at any time before it is voted at the Annual  Meeting
(i) by delivering a written  notice of revocation of such proxy to the Secretary
of the Company at the Company's  principal  executive office,  6850 N. Broadway,
Suite G, Denver,  Colorado 80221, (ii) by executing and delivering a later dated
proxy to the  Company or its  solicitation  agents,  or (iii) by  attending  the
Annual  Meeting and voting in person at the Annual  Meeting.  Attendance  at the
Annual Meeting will not, by itself, revoke a proxy.

        There is no limit on the number of times that a  stockholder  may revoke
his or her proxy prior to the Annual  Meeting.  Only the latest dated,  properly
signed proxy card will be counted.

        IF YOU ALREADY SENT A PROXY CARD TO AVF, A DISSIDENT STOCKHOLDER THAT IS
ATTEMPTING A HOSTILE TAKEOVER OF THE COMPANY, YOU MAY REVOKE THAT PROXY AND VOTE
IN  ACCORDANCE  WITH THE  RECOMMENDATIONS  OF THE BOARD OF DIRECTORS BY SIGNING,
DATING  AND  MAILING  THE  ENCLOSED  WHITE-STRIPED  PROXY  CARD IN THE  ENVELOPE
PROVIDED.


                                 PROPOSAL 1
                           ELECTION OF DIRECTORS

        The Company's Certificate and Bylaws, each as amended, currently provide
that the Board of  Directors  shall be divided  into three  classes,  each class
consisting,  as  nearly  as  possible,  of  one-third  of the  total  number  of
directors, with each class having a three-year term.

        The Company  currently has a total of four directors,  consisting of one
Class I director,  whose term  expires in 1998,  two Class II  directors,  whose
terms  expire in 1999 and one Class III  director,  whose term  expires in 2000.
Each of the  current  directors,  with  the  exception  of Bert  Fingerhut,  was
appointed to fill a vacancy on the Board created by the  resignations of Charles
Cohen, Ph.D., Donald Kennedy,  Ph.D. and Allen Misher,  Ph.D. effective July 21,
1998. Such resignations were not the result of any disagreement with the Company
and had been contemplated by Drs. Cohen, Kennedy and Misher earlier this year in
connection with the Company's  proposed merger with Biostar,  Inc., which merger
was  subsequently  abandoned.  

        The only director to be elected at the Annual  Meeting will be a Class I
director.  The Board of Directors has  nominated  Joachim von Roy as the Class I
director (term expiring 2001) to be elected at the Annual Meeting. However, AVF,
a dissident  stockholder,  is  attempting  to take  control and  circumvent  the
Company's  classified  Board of  Directors  by  proposing  Proposal  4 (the "AVF
Proposal")  which  would add  three new  directors  to the  Board  (two  Class I
directors,  with terms expiring  2001,  and one Class III director,  with a term
expiring 2000). The Board of Directors opposes the AVF Proposal and has proposed
Proposal 3, which would  protect the  Company's  classified  Board  structure by
eliminating the possibility of AVF or future dissident  stockholders from taking
control of the  Company  by  proposals  such as the AVF  Proposal.  However,  if
Proposal 3 is defeated and the AVF Proposal is properly  presented and approved,
then  four  directors  will be  elected  at the  Annual  Meeting.  The  Board of
Directors  has  conditionally  nominated  John C.  Cheronis,  M.D.,  Ph.D.,  and
Diarmuid  Boran  (collectively,  the  "Additional  Nominees") to fill two of the
three  vacancies  (for Class I director  and Class III  director,  respectively)
created in the event the AVF  Proposal is adopted and the Board is  increased to
seven members.

        Directors  are elected by a plurality of the votes  present in person or
represented by proxy and entitled to vote at the meeting.  Shares represented by
executed  WHITE-STRIPED  proxy card will be voted,  if authority to do so is not
withheld,  for the election of Mr. von Roy as Class I director and, in the event
the AVF Proposal is approved,  also for the  election of Dr.  Cheronis,  and Mr.
Boran as Class I and Class III directors, respectively.

        The persons nominated for election have agreed to serve if elected,  and
management  has no reason to believe that such nominees will be unable to serve.
However,  in the event that any of such nominees  becomes unable or unwilling to
accept  nomination  or election  as a result of an  unexpected  occurrence,  the
shares  represented by the enclosed proxy will be voted for the election of such
substitute nominee as management may propose.

        Set forth below is biographical  information for the persons  (including
the  Additional  Nominees)  nominated for election to the Board of Directors and
each other person  whose term of office as a director  will  continue  after the
Annual Meeting,  including  information  furnished by them as to their principle
occupations at present and for the past five years,  certain  directorships held
by each,  their ages as of July 15,  1998 and the year in which each  continuing
director became a director of the Company.

       The Board of Directors  recommends a vote FOR each of the nominees listed
below.


Nominee for Election as Class I Director

     Joachim von Roy Mr. von Roy,  51, has been a director of the Company  since
July 1998.  Mr.  von Roy is a  Principal  of RvR  Associates,  a  pharmaceutical
consulting  firm.  From 1993 to 1997,  he served as President  of  Bristol-Myers
Squibb  Pharmaceuticals,  Europe and,  from 1990 to 1993,  he was  President  of
Bristol-Myers Squibb Pharmaceuticals, Central Europe. Mr. von Roy is Chairman of
Health Initiative Europe Institute for Bagonalistics and a member of Kuratorium,
the German Lipid League.

Additional Nominees for Election as Class I and Class III Directors

         Class I Director:

     John C. Cheronis, Ph.D., M.D. Dr. Cheronis, 47, has been Founding Scientist
of the Company since 1996 and served as Vice President,  Research of the Company
from the Company's inception in 1982 to 1995. Dr. Cheronis was a director of the
Company from 1982 to 1995.  He is a diplomat of the  American  Board of Internal
Medicine.  Dr.  Cheronis  received his Ph.D.  and M.D.  from the  Department  of
Pharmacology and Physiology at the Pritzker School of Medicine of the University
of Chicago in 1978 and 1980, respectively.

         Class III Director:

     Diarmuid Boran.  Mr. Boran,  38, has served as Chief Operating  Officer and
Acting Chief Financial  Officer of the Company since May 1998. He served as Vice
President, Corporate Development and Planning of the Company from August 1995 to
May 1998 and prior to that time as Senior Director,  Commercial  Development and
Planning.  From 1988 to 1993,  Mr. Boran worked for Marion Merrell Dow Inc. (now
Hoechst  Marion  Roussel,  Inc.  where he held various  positions in  marketing,
strategic planning and finance,  most recently as Director of Corporate Business
Analysis.

Continuing Class II Director

         Bert Fingerhut.  Mr. Fingerhut,  54, has been a director of the Company
since 1988 and Chairman of the Board and Acting Chief  Executive  Officer  since
May 1998.  Mr.  Fingerhut also served as Chairman of the Board from June 1991 to
April 1997. In addition to his service with the Company, Mr. Fingerhut presently
pursues private business and conservation  interests.  From 1984 to 1985, he was
Special Limited Partner and Senior Vice President of Odyssey Partners, a private
investment  partnership.  From 1965 to 1983,  he was General  Partner,  Managing
Director,  Executive  Vice  President and Director of Research of  Oppenheimer &
Company,  Inc.,  an  investment  banking and brokerage  firm.  Mr.  Fingerhut is
Chairman of the Board of Directors of Toxics Targeting,  a private company based
in Ithaca, N.Y. that tracks and provides information on toxic waste sites. He is
currently Chairman of the Governing Council of The Wilderness  Society, a member
of the Board of Directors of the Southern Utah Wilderness  Alliance,  a director
of the Grand Canyon Trust and Trustee of the Alaska Conservation Foundation. Mr.
Fingerhut also serves as a director of the Wyss Foundation.

     John E.  Repine,  M.D. Dr.  Repine,  51, has been a director of the Company
since  July  1998.  Dr.  Repine  has  been the  President  and  Director  of the
Webb-Waring Anti-Oxidant Institute for Biomedical Research. He is also the James
J.  Waring  Professor  in the  Department  of  Medicine  and  Pediatrics  at the
University of Colorado  Health  Sciences  Center.  Dr. Repine was elected to the
American  Society of  Clinical  Investigation  and the  Association  of American
Physicians.  He is also the recipient of an Established  Investigator Award from
the American Heart Association,  Basil O'Connor Research Award from the March of
Dimes and the Bonfils-Stanton Award for his outstanding contribution to medicine
and science.  Dr. Repine serves on the scientific advisory boards of a number of
biotechnology companies. He currently holds 6 patents.

<PAGE>

Continuing Class III Directors

        Edward  Finkelstein.  Mr.  Finkelstein,  61, has been a director  of the
Company since July 1998. Mr.  Finkelstein has been a managing  partner of REM, a
real estate holding  company since 1986,  and the President and Chief  Executive
Officer  of  Edmark  Development,  a  commercial  real  estate  development  and
management  company,  since 1990.  He has also served as the President and Chief
Executive  Officer of  Central  Motors,  a holding  company  of  Midwestern  car
dealerships,  since  1991,  and the  Chairman  and Chief  Executive  Officer  of
Rollabind,  Inc.,  the largest  manufacturer  of patented  disc binding  systems
worldwide,  since 1996. Between 1972 and 1991, Mr. Finkelstein was President and
Chief  Executive  Officer of Michigan  Sporting  Goods  Distributors,  Inc., the
parent company of MC Sports,  one of the largest retail  sporting good chains in
the world.


                                   PROPOSAL 2
                          APPROVAL OF THE REVERSE SPLIT

         The Board of  Directors  of the  Company  has  unanimously  approved an
amendment to its Certificate of  Incorporation  to effect a reverse split of the
Company's  Common Stock and make a  corresponding  reduction  in the  authorized
number of shares of Common  Stock  which the  Company  may issue  (such  actions
collectively  being referred to as the "Reverse  Split").  The Reverse Split, if
approved by stockholders,  would cause all issued and outstanding  shares of the
Company's  Common Stock to be split,  on a reverse  basis,  one-for-four  (i.e.,
stockholders  would receive one share of Common Stock for every four shares held
by them prior to the Reverse  Split).  If the  Reverse  Split is approved at the
Annual Meeting, the Company intends to file the Reverse Split with the Secretary
of State of Delaware as soon as  practicable  thereafter,  upon which  filing it
will be effective.  As described  below,  the primary  objective of the Board in
effecting  the Reverse  Split is to increase  the per share  market price of the
Common Stock.

         As part of the Reverse Split,  Article V, Section 1 of the  Certificate
of Incorporation would be amended to decrease the authorized number of shares of
capital stock which the Company may issue from  52,000,000  shares to 14,500,000
shares,  12,500,000 of which shall be Common Stock, and 2,000,000 of which shall
be Preferred Stock.

         By letter dated July 13, 1998, the Nasdaq Stock Market, Inc. ("Nasdaq")
advised  the  Company  that,  as of the  close of  business  on such  date,  the
Company's  Common  Stock would be delisted  from the Nasdaq  National  Market as
result of the Company's  failure to comply with Nasdaq's minimum $1.00 per share
bid price requirement.  The Company is in the process of appealing the delisting
of its Common Stock and believes that if the Reverse Split is approved  there is
a reasonable  likelihood  that Nasdaq will reinstate the Nasdaq  National Market
listing  of the  Common  Stock,  although  there  can be no  assurance  that the
Company's appeal will be successful or, if successful, that the Company would be
able to  maintain  such  listing  (whether  as a result of  failure  to meet the
minimum bid price requirement or other requirements imposed by Nasdaq).

         The Board of Directors believes that the Reverse Split is beneficial to
the Company's  future  prospects since it will not have  reasonable  grounds for
appealing the delisting of its Common Stock from the Nasdaq  National  Market if
the  Reverse  Split does not take  place and if the market  price for the Common
Stock does not otherwise meet Nasdaq's $1.00 minimum bid price.

         For the foregoing reasons, the Board of Directors has determined that a
recapitalization through the Reverse Split would be in the best interests of the
Company and its stockholders.

Effects of the Reverse Split

         General Effects.  The principal effect of the Reverse Split would be to
decrease  the  number of  outstanding  shares  of the  Company's  Common  Stock.
Specifically,  the 18,523,918  shares of Common Stock issued and  outstanding on
the Record  Date would,  as a result of the Reverse  Split,  be  converted  into
approximately  4,630,979  shares  of  Common  Stock  (with  the  precise  number
depending upon the extent of fractional shares resulting from the Reverse Split,
which will be  converted  to cash  based  upon the  market  price for a share of
Common Stock on the trading day prior to  implementation  of the Reverse Split).
The number of shares of Common Stock  authorized  for issuance by the  Company's
Certificate   of   Incorporation   following   the   Reverse   Split   would  be
proportionately   adjusted  from   50,000,000   shares  to  12,500,000   shares.
Accordingly,  after the Reverse Split,  there would be  approximately  7,869,021
"new" (or  post-Reverse  Split) shares of Common Stock ("New Shares")  available
for issuance by the Company.

<PAGE>

         Effect on Market for Common Stock.  On July 23, 1998, the closing price
of the Company's  Common Stock as quoted on the OTC Bulletin Board was $0.51 per
share. By decreasing the number of shares of Common Stock otherwise  outstanding
without altering the aggregate  economic interest in the Company  represented by
such  shares,  the  Board  believes  that the per  share  market  price  for the
Company's  Common  Stock will be  increased  in excess of the minimum  $1.00 bid
price required for inclusion of shares on the Nasdaq National Market.

         Effect on Stock  Options and  Warrants.  The total  number of shares of
Common Stock  issuable upon the exercise of options and warrants to acquire such
shares,  and the exercise price  thereof,  shall be  proportionally  adjusted to
reflect the Reverse Split.

         Effect under the Company's Rights Plan. Following the implementation of
the  Reverse  Split,  each  share of  Common  Stock  will  continue  to have one
preferred  share purchase right (a "Right")  associated  with it;  however,  the
number of shares of  Preferred  Stock  issuable  upon the exercise of each Right
shall be proportionally  adjusted to reflect the Reverse Split (i.e.,  following
the effectiveness of the Reverse Split, each Right, under certain circumstances,
would be eligible to purchase up to four  one-hundredths of a share of Preferred
Stock).

         Changes in  Stockholders'  Equity.  The Reverse  Split would reduce the
Company's  stated  capital,  which consists of the par value per share of Common
Stock multiplied by the number of such shares outstanding, from the amount which
would otherwise  exist (assuming the share amounts set forth above,  the Reverse
Split would reduce the Company's  stated capital by  approximately  $27,776.20).
Although  the par  value of  Common  Stock  would  remain  at  $0.002  per share
following  the Reverse  Split,  stated  capital  would be decreased  because the
number of shares  outstanding would be reduced.  Correspondingly,  the Company's
additional paid-in capital,  which consists of the difference between its stated
capital and the  aggregate  amount paid to the Company  upon its issuance of all
then outstanding shares of Common Stock, would be increased.

     Appraisal  Rights.  Pursuant to the  Delaware  General  Corporate  Law, the
Company's  stockholders are not entitled to appraisal rights with respect to the
Reverse Split.

Federal Income Tax Consequences

         The following  summary of the federal  income tax  consequences  of the
Reverse Split is based on current law,  including  the Internal  Revenue Code of
1986, as amended, and is for general information only. The tax treatment for any
stockholder may vary depending upon the particular  facts and  circumstances  of
such  stockholder.   Certain   stockholders,   including  insurance   companies,
tax-exempt organizations, financial institutions,  broker-dealers,  non-resident
aliens,  foreign  corporations  and persons who do not hold Common  Stock of the
Company as a capital asset, may be subject to special rules not discussed below.
Accordingly, each stockholder should consult his or her tax advisor to determine
the particular tax  consequences  to him or her of the Reverse Split,  including
the application and effect of federal,  state, local or foreign income taxes and
other laws.

         The receipt of whole New Shares  (excluding  fractional  New Shares) in
the  Reverse  Split  should be  non-taxable  for  federal  income tax  purposes.
Consequently,  a stockholder receiving New Shares will not recognize either gain
or loss, or any other type of income,  with respect to whole New Shares received
as a  result  of  the  Reverse  Split.  In  addition,  the  tax  basis  of  such
stockholder's  shares of Common Stock prior to the Reverse Split will carry over
as the tax basis of the stockholder's New Shares.  The holding period of the New
Shares should also include the stockholder's  holding period of the Common Stock
prior to the Reverse  Split,  provided  that such  Common  Stock was held by the
stockholder as a capital asset on the effective date of the Reverse Split.

         Any  stockholder  who receives  cash in lieu of a fractional  New Share
pursuant  to the  Reverse  Split  will  recognize  gain  or  loss  equal  to the
difference  between the amount of cash received and the portion of the aggregate
tax basis in his or her shares of Common Stock  allocable to such fractional New
Share.  If the  shares of  Common  Stock  were  held as a  capital  asset on the
effective date of the Reverse Split, then the stockholder's gain or loss will be
a capital gain or loss.  Such  capital gain or loss will be a long-term  capital
gain or loss if the stockholder's  holding period for the shares of Common Stock
is  longer  than  eighteen  months,  a  short-term  capital  gain or loss if the
stockholder's  holding period is twelve months or less and mid-term gain or loss
if the  stockholder's  holding period is longer than twelve months and less than
eighteen months.

<PAGE>

         Based on certain  exceptions  contained  in  regulations  issued by the
Internal  Revenue  Service,  the  Company  does  not  believe  that  it  or  its
stockholders would be subject to backup  withholding or informational  reporting
with respect to cash distributed in lieu of fractional New Shares.

Exchange Of Shares

         On or after the effective date of the Reverse  Split,  the Company will
mail to each stockholder of record a letter of transmittal. Stockholders will be
able to receive a certificate  representing New Shares and, if applicable,  cash
in lieu of a fractional  New Share only by  transmitting  to the Exchange  Agent
such stockholder's  stock  certificate(s) for shares of Common Stock outstanding
prior to the Reverse  Split,  together with the properly  executed and completed
letter of  transmittal,  and such  evidence of  ownership  of such shares as the
Company may require.  Stockholders will not receive  certificates for New Shares
unless and until the  certificates  representing  their  shares of Common  Stock
outstanding prior to the Reverse Split are surrendered.  Stockholders should not
forward their certificates to the Exchange Agent until the letter of transmittal
is received and should  surrender  their  certificates  only with such letter of
transmittal.

         Payment  in  lieu  of a  fractional  New  Share  will  be  made  to any
stockholder  entitled  thereto  promptly  after  receipt  by the  Company or its
Exchange  Agent  of  a  properly  completed  letter  of  transmittal  and  stock
certificate(s) for all of his or her shares of Common Stock outstanding prior to
the Reverse Split.  There will be no service charge payable by  stockholders  in
connection  with the exchange of  certificates or in connection with the payment
of cash in lieu of the issuance of a fractional  New Share.  These costs will be
borne by the Company.

Required Vote

         The  affirmative  vote of the  holders of a majority  of the issued and
outstanding  shares entitled to vote on the matter at the Annual Meeting will be
required to approve the Reverse Split described in this Proposal 2.

         The Board of Directors recommends a vote FOR Proposal 2.



                                   PROPOSAL 3

          APPROVAL OF AMENDMENT TO CERTIFICATE OF INCORPORATION UPHOLDING
                  BOARD'S AUTHORITY TO FIX THE NUMBER OF DIRECTORS

         Article IX,  Section 1 of the Company's  Certificate  of  Incorporation
currently  provides  that the number of directors of the Company  shall be fixed
from time to time in the manner  provided in the Bylaws and may be  increased or
decreased  from time to time in the manner  provided in the  Bylaws.  Article 3,
Section 3.1 of the Company's Bylaws provides, in pertinent part, that the number
of directors  shall be one or more,  as fixed from time to time by resolution of
the Board of  Directors.  The Board of  Directors  has  unanimously  approved an
amendment to the Company's  Certificate of  Incorporation to restate Article IX,
Section 1 in its  entirety as follows:  "The exact  number of  directors  of the
Company  shall be  determined  from time to time by  resolution  of the Board of
Directors."

         The  proposed  amendment is designed to resolve the question of whether
dissident   stockholders  can  circumvent  the  Company's  classified  Board  of
Directors by amending  the Bylaws to increase  the number of directors  and then
nominating  directors to fill the vacancies created by the Bylaw amendment.  The
Board of Directors  believes that it is in the best interests of the Company and
its stockholders to defeat cheap efforts, such as those currently being employed
by AVF through the AVF Proposal (described under Proposal 4), to take control of
the Board.

<PAGE>

         The Company has had a classified  Board structure since 1992. The Board
of Directors  believes that a classified  Board  continues to serve the Company,
its  stockholders  and those with whom the  Company is seeking to do business by
permitting all to rely on the  consistency  and continuity of corporate  policy.
This is  particularly  important to a  research-based  organization  such as the
Company,  where product development often requires many years. At the same time,
annual elections in which  approximately  one-third of the Board is elected each
year  offer  stockholders  a  regular  opportunity  to  renew  and  reinvigorate
corporate  decision-making  while  maintaining  the basic integrity of corporate
policy from year-to-year.

         In addition,  in the event of any unfriendly or unsolicited proposal to
take over or  restructure  the  Company,  such as the hostile  takeover by proxy
contest  currently being undertaken by AVF, a classified board structure permits
the Company to negotiate with the sponsor, to consider alternative proposals and
to assure that stockholder value is maximized.

         The Board of Directors  believe that the approval of the  amendment set
forth in this  Proposal 3 is  important  in order to uphold the Board's  current
authority to fix the number of directors and, more importantly, to eliminate the
possibility of AVF or future dissident  stockholders  from taking control of the
Company by  proposals,  such as the AVF Proposal,  to  circumvent  the Company's
classified Board structure.

         The  affirmative  vote of the  holders of a majority  of the issued and
outstanding  shares entitled to vote on the matter at the Annual Meeting will be
required for the adoption of the amendment contained in this Proposal 3.

         The Board of Directors recommends a vote FOR Proposal 3.


                                   PROPOSAL 4
   SOLICITATION IN OPPOSITION TO AVF PROPOSAL TO INCREASE SIZE OF THE BOARD

         Article 3, Section 3.1 of the Company's Bylaws currently  provides,  in
pertinent part, that the number of directors shall be one or more, as fixed from
time  to  time  by  resolution  of the  Board  of  Directors.  According  to the
Opposition  Proxy, AVF proposes to amend Article 3, Section 3.1 of the Bylaws to
fix the number of  directors  to serve on the Board of  Directors  at seven.  As
asserted  by AVF in the  Opposition  Proxy,  the AVF  Proposal  is  designed  to
circumvent the Company's classified Board of Directors and enable AVF to elect a
majority of the Board, thereby seizing control of the Company.

         The Board of  Directors  believes  that the AVF  Proposal is not in the
best interests of the Company and its stockholders  and has unanimously  adopted
Proposal 3, which would amend the  Company's  Certificate  of  Incorporation  to
prevent AVF or other dissident  stockholders from attempting to seize control of
the Company by proposing such a Bylaw  amendment.  In addition to helping assure
continuity and stability of the Company's  corporate policies and strategies,  a
classified  board  structure  permits  the  Company,  in the  face of a  hostile
takeover attempt or unsolicited proposal, time to negotiate with the sponsor, to
consider  alternative   proposals  and  to  assure  that  stockholder  value  is
maximized--in  other  words,  the  classified  board is  designed to protect the
Company  and  stockholders  precisely  against  corporate  raiders  such  as Mr.
Koether. Given Mr. Koether's documented history of greenmail,  hostile takeovers
and  contentious  litigation,  the Board of  Directors  urges  you to  carefully
consider the Board's reasons for opposing Proposal 4.

         AVF presently  owns  approximately  10.8% of the Company's  outstanding
Common Stock (approximately 15% when combined with the holdings of Mark and Fred
Jaindl who are  participating in the Opposition Proxy  solicitation),  acquiring
its  interest  in the  fall of 1997  with the  announced  intention  of  seeking
representation  on the Board  through a proxy  contest or  otherwise.  In recent
months  the  Board of  Directors  has  worked  hard to try to  negotiate  a fair
settlement with Mr. Koether, but he appears to want nothing less than control of
the Company for his (and the Jaindl's) 15% interest.  The Board urges holders of
the remaining 85% of the Company's  outstanding  Common Stock to look beyond Mr.
Koether's  rhetoric about restoring  corporate  democracy to his hostile actions
over the past  twenty  years that have  frequently  been in pursuit of  personal
enrichment at the expense of the target company and its other stockholders.

<PAGE>

         The  affirmative  vote of the  holders of a majority  of the issued and
outstanding  shares  present in person or  represented  by proxy and entitled to
vote at the Annual  Meeting  will be  required  to approve  the Bylaw  amendment
described in this Proposal 4.

         In order to defeat the  hostile  takeover  attempt by Mr.  Koether  and
ensure  that the  interests  of all the  Company's  stockholders  are taken into
account, the Board of Directors recommends a vote AGAINST Proposal 4.



                                   PROPOSAL 5
               RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

         The  Board  of  Directors  has  selected  Arthur  Andersen  LLP  as the
Company's  independent auditors for the fiscal year ending December 31, 1998 and
has  further  directed  that  management  submit the  selection  of  independent
auditors for  ratification by the  stockholders  at the Annual  Meeting.  Arthur
Andersen  LLP  has  audited  the  Company's  financial  statements  since  1989.
Representatives  of Arthur Andersen LLP are expected to be present at the Annual
Meeting, will have an opportunity to make a statement if they so desire and will
be available to respond to appropriate questions.

         Stockholder ratification of the selection of Arthur Andersen LLP as the
Company's  independent  auditors  is not  required  by the  Company's  Bylaws or
otherwise. However, the Board is submitting the selection of Arthur Andersen LLP
to the stockholders for ratification as a matter of good corporate practice.  If
the stockholders fail to ratify the selection, the Audit Committee and the Board
will  reconsider  whether or not to retain that firm.  Even if the  selection is
ratified,  the Board in its discretion  may direct the  appointment of different
independent  auditors at any time during the year if they  determine that such a
change would be in the best interests of the Company and its stockholders.

         The affirmative vote of the holders of a majority of the shares present
in person or  represented  by proxy and  entitled to vote at the Annual  Meeting
will be  required  to  approve  Proposal 5  ratifying  the  selection  of Arthur
Andersen LLP.

         The Board Of Directors recommends a vote FOR Proposal 5.



<PAGE>



                             SECURITY OWNERSHIP OF
                   CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

        The  following  table  sets  forth  certain  information  regarding  the
ownership  of the  Company's  Common  Stock  as of July 24,  1998  by:  (i) each
director and nominee for director;  (ii) each of the executive officers named in
the Summary  Compensation  Table under the caption  "Compensation  of  Executive
Officers" below;  (iii) all executive officers and directors of the Company as a
group;  and (iv) all those known by the Company to be beneficial  owners of more
than five percent of its Common Stock.



                                                  Beneficial Ownership (1)

Name of Beneficial Owner                 Number of Shares       Percent of Total

Asset Value Fund Limited Partnership(2)       2,000,000               10.80%
 P.O. Box 74
 Bedminister, NJ

BVF Partners, L.P.(3)                          1,180,752               6.37%
 333 West Wacker Drive, Suite 1600
 Chicago, IL

Bert Fingerhut(4)                                563,205               3.02%

John E. Repine (5)                                   --                 --

Joachim von Roy                                      --                 --

Edward Finkelstein                               444,025               2.40%

Diarmuid Boran(6)                                107,225                 *

Joseph L. Turner(7)                              140,984                 *

Kenneth R. Lynn                                    3,433                 *

All executive officers 
and directors as a group (7 persons)(8)        1,662,164               8.78%
- --------------------

* Less than one percent.

(1)    This table is based upon information  supplied by the Company's officers,
       directors and principal stockholders and Schedules 13D and 13G filed with
       the  Securities and Exchange  Commission  (the "SEC").  Unless  otherwise
       indicated  in the  footnotes  to this  table  and  subject  to  community
       property  laws where  applicable,  the Company  believes that each of the
       stockholders  named in this table has sole  voting and  investment  power
       with respect to the shares  indicated as beneficially  owned.  Applicable
       percentages are based on 18,523,918 shares  outstanding on July 15, 1998,
       adjusted as required by rules promulgated by the SEC.

(2)     According to Amendment  No. 12 to the Schedule 13D filed with the SEC on
        July 17, 1998 by Asset Value. The sole general partner of Asset Value is
        Asset Value  Management,  Inc., a Delaware  corporation and wholly owned
        subsidiary of Kent Financial Services, Inc., a Delaware corporation.  On
        February 10,  1998,  Mark W. Jaindl and  Frederick  J. Jaindl  acquired,
        respectively,  250,000 shares and 520,000 shares of Company Common Stock
        from Asset Value in a privately negotiated  transaction.  Mark Jaindl is
        the son of Fred Jaindl and a director of a company which might be deemed
        to be under the common  control of Asset Value by virtue of common stock
        ownership.  Although  Asset Value and the Jaindls  file  jointly,  Asset
        Value  disclaims  membership  in a group with the Jaindls and  disclaims
        beneficial ownership of the shares owned by the Jaindls.

(3)     According  to  Schedule  13D  filed  with  the  SEC on May  16,  1997 by
        Biotechnology  Value Fund,  L.P.  ("BVF").  Includes  638,796 Shares BVF
        beneficially  owns and has shared  dispositive and voting power with BVF
        Partners,  L.P.  ("Partners").  Partners  and BVF Inc.  share voting and
        dispositive  power over the 1,180,752  shares they own with, in addition
        to BVF, the managed  accounts on whose behalf  Partners,  as  investment
        manager, purchased such shares.

(4)     Includes  options to  purchase  153,010  shares,  which are  exercisable
        within 60 days of the date of this table.  Also  includes  3,000  shares
        held by Mr.  Fingerhut's wife and 17,000 shares by Mr. Fingerhut's minor
        daughter.

(5)     Includes options to purchase 16,500 shares, which are exercisable within
        60 days of this table.

(6)     Includes options to purchase 105,716 shares, which are exercisable
        within 60 days of the date of this table.

(7)     Includes options to purchase 128,066 shares, which are exercisable 
        within 60 days of the date of this table.

(8)     Includes options to purchase a total of 403,292 shares, which are 
        exercisable within 60 days of the date of this table by executive 
        officers and directors.


                          BOARD COMMITTEES AND MEETINGS

        During the year ended  December  31, 1997,  the Board of Directors  held
nine meetings.  Each incumbent  director then in office attended at least 75% of
the  aggregate  number of meetings of the Board and of the  Committees  on which
such  director  served.  The  Board  has  an  Audit  Committee,  a  Compensation
Committee, an Equity Committee and a Nominating Committee.

        The Audit  Committee  meets with the Company's  independent  auditors at
least  annually  to review  the  results  of the annual  audit and  discuss  the
financial  statements;  recommends to the Board the  independent  auditors to be
retained;  and receives and considers the accountants'  comments as to controls,
adequacy of staff and management  performance  and procedures in connection with
audit  and  financial  controls.  The Audit  Committee,  which  during  1997 was
composed of Mr. Fingerhut and Dr. Cohen, met once during 1997.

        The Compensation Committee makes recommendations concerning salaries and
incentive  compensation,   awards  stock  options  to  officers,  employees  and
consultants  under the  Company's  stock option plans and  otherwise  determines
compensation levels and performs such other functions regarding  compensation as
the Board may  delegate.  The  Compensation  Committee,  which  during  1997 was
composed of Mr. Fingerhut and Drs. Kennedy and Misher, met once during 1997.

        The Equity  Committee  administers  the Company's stock option plans for
non-officer  employees  only and makes stock option grants to such employees not
in excess of 20,000  shares.  All option  grants in excess of this limit and all
option grants to officers must be approved by the  Compensation  Committee.  The
Equity  Committee,  which during 1997 was composed of Mr. Lynn, did not take any
action during 1997.

        The Nominating Committee interviews, evaluates, nominates and recommends
individuals  for  membership  on the Board of Directors  and  committees  of the
Board, and for election as officers of the Company, and, in connection with such
duties,  monitors  and makes  recommendations  with respect to  compensation  of
directors.  No procedure has been established for the  consideration of nominees
recommended by the stockholders.  In addition,  the Nominating Committee reviews
certain matters of Board governance, including evaluation of committee structure
and function and Board performance.  The Nominating Committee, which during 1997
was composed of Drs.
Kennedy and Misher, did not meet during 1997.


                             EXECUTIVE COMPENSATION

Compensation of Directors

        Under the 1992 Amended and Restated Non-Employee Directors' Stock Option
Plan (the "1992  Directors'  Plan"),  which expired by its terms on December 31,
1997, each  non-employee  director  received options to purchase Common Stock of
the Company as  compensation  for his or her services as a director and received
additional  options  under such Plan for  service on certain  committees  of the
Board.  In addition,  options were, and continue to be, granted to  non-employee
directors  outside  of such  Plan.  To  date,  no plan  has  replaced  the  1992
Directors' Plan. Outside directors receive $1,000 per Board meeting attended and
$1,000 per committee  meeting  attended if held on a non-Board  meeting occasion
and an additional $6,000 annually.

        Option  grants  under  the  1992  Directors'  Plan  were  automatic  and
non-discretionary. Each person who was a non-employee director of the Company as
of the adoption date of the 1992 Directors'  Plan was granted options  generally
covering  25,000 shares,  with  adjustments  to equalize the directors'  overall
options in light of options  previously  granted to them. Such options generally
become  exercisable  ("vest") in year-end  installments  of 5,000  shares.  Each
member of the  Compensation  and Audit  Committees  received options covering an
additional  500 shares for each committee on which he served.  In addition,  (a)
each person subsequently  elected for the first time as a non-employee  director
is granted an option on the date of his or her initial election as a director to
purchase a pro rata portion of 25,000  shares,  depending upon when he or she is
elected,  which options generally vest in year-end installments of 5,000 shares;
(b)  each  person  subsequently  elected  for the  first  time to the  Audit  or
Compensation  Committee  is granted an option to purchase  500 shares if elected
before July 1, or a portion  thereof,  prorated on a quarterly basis, if elected
after such date, vesting in full on December 31; (c) each non-employee  director
receives an annual option to purchase an additional number of shares, determined
by  multiplying  5,000  by a  fraction,  the  numerator  of which is $20 and the
denominator  of which is the fair market  value per share of the Common Stock on
the grant date, subject to minimum and maximum limits of 2,500 and 5,000 shares,
respectively,  vesting  quarterly  over five  years;  and (d) each  non-employee
director  who is a  member  of the  Company's  Audit or  Compensation  Committee
receives an annual  option to purchase  500 shares,  vesting in full on December
31.  Vesting of all options is subject to  continued  service as a  non-employee
director or employee of the Company  during the vesting  period and, in the case
of options  granted  for service on a  committee,  to  continued  service on the
applicable  committee.  As of July 15, 1998,  1,650  options had been  exercised
under the 1992 Directors' Plan.

        All non-employee directors are reimbursed for their expenses incurred in
attending  Board of  Directors  meetings.  Directors  who are  employees  of the
Company do not receive separate compensation for their services as directors.

        During the fiscal year ended December 31, 1997,  Mr.  Fingerhut and Drs.
Cohen,  Misher and Kennedy received options pursuant to the 1992 Directors' Plan
covering   6,000  shares,   5,000   shares,   5,500  shares  and  5,500  shares,
respectively, each at an exercise price of $1.47 per share.

Compensation of Executive Officers

        The following  table shows for the fiscal years ended December 31, 1997,
1996 and 1995,  compensation  awarded or paid to, or earned by,  each person who
served as (i) the Company's  Chief  Executive  Officer  during 1997 and (ii) the
Company's other most highly compensated  executive officers at December 31, 1997
(collectively the "Named Executive Officers"):


                         SUMMARY COMPENSATION TABLE

                                                              Long-Term
                             Annual Compensation            Compensation
                                                               Awards

Name and                                            OtherAnn.  Sec.'s  All Other
Principal Position    Year   Salary ($)   Bonus ($) Comp($)  Underlying  Comp.
                                                             Options(#) ($)(1)

Kenneth R. Lynn (2)     1997  $265,513    $65,000    --        --         $1,141
  President, Chief      1996   265,006     65,000    --      75,000        1,174
  Executive Officer and 1995   230,499     75,000    --     275,000        1,099
  Chairman of the Board

Joseph L. Turner (3)    1997   165,537         --    --        --          2,165
  Vice President, Finance 1996 154,533     25,000    --      40,000        2,399
  and Administration,   1995   155,349     30,000    --      64,000        2,009
  Chief Financial Officer
  and Secretary

Diarmuid Boran (4)      1997   140,364     30,000    --        --          1,708
  Vice President,       1996   140,046     25,000    --      40,000        1,707
  Corporate Development 1995   112,493     30,000    --      64,000        1,386
  and Planning

- -----------------

(1)      Includes  matching  payments by the  Company  under its 401(k) Plan and
         premiums paid by the Company for group term life  insurance.  For 1997,
         the amounts were $631 and $510, respectively,  for Mr. Lynn; $1,295 and
         $870, respectively,  for Mr. Turner; and $1,404 and $304, respectively,
         for Mr. Boran.

(2)       Mr. Lynn left all  positions  with the Company as of May 18, 1998.  In
          accordance with the Board's  determination  that Mr. Lynn's  departure
          constituted a Termination  Event under the Executive  Compensation and
          Benefits  Agreement  dated as of October 14, 1997  between the Company
          and Mr. Lynn,  Mr. Lynn was entitled to receive the benefits  provided
          thereunder,  subject  to the  modifications  set  forth in the  letter
          agreement  dated May 18, 1998 between Mr. Lynn and the Board:  (i) the
          lump salary  continuation  payment was limited to 20 months  salary or
          $441,667,  (ii) no pro rata  bonus was paid and (iii) all  outstanding
          options held by Mr. Lynn were terminated and extinguished. Pursuant to
          the letter  agreement,  Mr. Lynn agreed to make himself available as a
          consultant  to the  Company  through  June 30, 1998 at a rate equal to
          half of his former  rate of  compensation;  consulting  fees  totaling
          $15,726  were paid to Mr. Lynn during such period.  In  addition,  the
          Company  entered into an indemnity  agreement with Mr. Lynn whereby it
          agreed to indemnify him against claims arising in connection with acts
          or  omissions  arising out of his  service as a  director,  executive,
          employee, consultant and/or agent of the Company.

(3)      Mr.  Turner  resigned as an officer  and  employee of the Company as of
         December 1, 1997. At such time, Mr. Turner and the Company entered into
         an agreement  pursuant to which Mr. Turner  served as a consultant  and
         continued to receive his former  salary  through  June 30, 1998.  Stock
         options held by Mr. Turner at the time of his resignation  continued to
         vest until June 30, 1998.

(4)      Mr. Boran became an executive  officer in 1995. In May 1998,  Mr. Boran
         was  appointed  Chief  Operating  Officer  and Acting  Chief  Financial
         Officer of the Company.

Stock Option Grants and Exercises

         The Company  grants  options to its executive  officers  under its 1993
Equity  Incentive  Plan.  No options  were  granted to the  Company's  executive
officers in 1997.  As of July 15,  1998,  options to purchase a total of 632,483
shares  were  outstanding  under the 1993 Equity  Incentive  Plan and options to
purchase 836,627 shares remained available for grant thereunder.


          Aggregated Option Exercises in Fiscal 1997 and Value of Options
                                 At End of Fiscal 1997

                                      Number of Securities  Value of Unexercised
                                      Underlying Unexercised     In-the-Money
                                         Options at End of    Options at End of
               Shares Acquired   Value    Fiscal 1997 (#)     Fiscal 1997($)(1)
Name           On Exercise (#) Realized ($)                  Exercisable/Unexer.

Kenneth R. Lynn       --          --     275,009/174,991           $0/$0
Joseph L. Turner      --          --     101,305/62,695              0/0
Diarmuid Boran        --          --      79,940/66,560              0/0
- ----------------

(1)      Based on the closing price of the Company's Common Stock on December
         31, 1997 ($0.594) minus the exercise price of the options.

Employment Contracts and Severance Plan

         The Company adopted the Executive Officers' Severance Benefit Plan (the
"Severance Plan") on September 18, 1995, which was amended on December 13, 1996,
to encourage senior employees to work in the Company's best interests  following
a change in control.  In the event of an  involuntary  termination of employment
within 60 days prior and 30 months following a change in control,  all employees
employed  at the  level of Vice  President  or above and such  other  management
employees  as may be  designated  by the Chief  Executive  Officer  will receive
compensation  during the Benefit Period (defined  below),  a proportional  bonus
payment if one was received the year preceding the year in which the termination
date occurs, and all outstanding unvested stock options will become fully vested
on the termination date. The "Benefit Period" for employees other than the Chief
Executive  Officer  is the period  commencing  on the  termination  date and (i)
continues  for 18 months  following  such date if the date occurs within 60 days
prior or 12 months after a change in control,  or (ii)  continues for the period
following  the date the  employee  becomes  eligible  determined  by reducing 30
months by the number of months the eligible employee was employed by the Company
following a change in control.  With respect to the Chief Executive Officer, the
"Benefit  Period"  is the Chief  Executive  Officer's  termination  date and (i)
continues  for 24 months  following  such date if the date occurs within 60 days
prior or 12 months after a change in control,  or (ii)  continues for the period
following such  termination  date determined by reducing 36 months by the number
of months the Chief  Executive  Officer was employed by the Company  following a
change in control.

     The Company amended its Executive  Compensation  and Benefits  Continuation
Agreement  with Mr. Lynn (the  "Employment  Agreement")  on October 14, 1997. As
amended,  the agreement  provided,  upon the  occurrence of a Termination  Event
(defined below), for the payment of the equivalent of 24 months base salary, the
payment  of  health  insurance  policies  for  up to  18  months  following  the
Termination Event, immediate vesting of all stock options not already vested and
the  payment  of a bonus  (equal to the  fraction  of the  current  year  worked
multiplied  by the bonus paid for the prior  year).  A  "Termination  Event" was
defined as the involuntary  termination of Mr. Lynn by the Company without cause
or the  termination of employment by Mr. Lynn on account of a material change in
the  business  of the  Company or the  duties of Mr.  Lynn prior to or within 30
months  after a change in control of  Company.  The  Employment  Agreement  also
provided that,  with respect to any  Termination  Event that was also covered by
the Severance Plan, Mr. Lynn would receive compensation and benefits pursuant to
the  Employment  Agreement  only and not  pursuant  to the  Severance  Plan.  In
connection with his departure from the Company on May 18, 1998, Mr. Lynn entered
into a  letter  agreement  with  the  Company  that  modified  the  terms of the
Employment  Agreement as  described in footnote (2) to the Summary  Compensation
Table above.

         In connection with arrangements  relating to the proposed  agreement of
merger  between  Cortech and BioStar,  Inc. (the  "Merger"),  which proposal has
since been  terminated,  Cortech  entered into an agreement  with Mr. Boran (the
"Boran  Agreement")  which  provides  that the cash  benefits  payable under the
Severance Plan would have been paid to Mr. Boran upon the  effectiveness  of the
Merger.  The Boran Agreement further provides that benefits  available under the
Severance Plan would also be paid to Mr. Boran (with cash payments made over the
course of six months) in the event of Mr. Boran's involuntary termination in the
absence of the Merger and that  Cortech  would have  employed  Mr.  Boran at his
current  salary as a  full-time  consultant  for the six  months  following  the
effectiveness of the Merger.  The Boran Agreement  continues to be in full force
and effect.

Compensation Committee Interlocks and Insider Participation

         The members of the Company's  Compensation  Committee  during 1997 were
Drs.  Kennedy and Misher and Mr.  Fingerhut.  There were no  interlocks or other
relationships  among the Company's  executive  officers and  directors  that are
required to be disclosed  under  applicable  executive  compensation  disclosure
regulations.


                 REPORT TO STOCKHOLDERS ON EXECUTIVE COMPENSATION

         The Compensation  Committee of the Board of Directors (the "Committee")
consisted during 1997 of Drs. Kennedy and Misher, each of whom resigned from the
Board effective July 21, 1998, and Mr.  Fingerhut.  The Committee is responsible
for recommending and administering  the Company's  policies  governing  employee
compensation  and  for  administering  the  Company's  employee  benefit  plans,
including  its  stock  plans.   The  Committee   evaluates  the  performance  of
management,   recommends   compensation   policies   and   levels,   and   makes
recommendations  concerning salaries and incentive compensation.  The full Board
of Directors reviews the Committee's  recommendations regarding the compensation
of the executive officers of the Company.

         It is the Company's  policy generally to qualify  compensation  paid to
executive  officers  for  deductibility  under  Section  162(m) of the  Internal
Revenue Code (the "Code").  Section 162(m) limits the Company to a deduction for
federal income tax purposes of no more than $1 million of  compensation  paid to
certain executive officers in a taxable year.  Compensation above $1 million may
be deducted if it is "performance-based"  compensation within the meaning of the
Code. The Compensation Committee has determined that stock options granted under
the  Company's  1993 Equity  Incentive  Plan with an exercise  price equal to at
least the fair market value of the  Company's  Common Stock on the date of grant
shall  be  treated  as  "performance-based  compensation,"  to  the  extent  the
requirements  of Section 162(m) are otherwise  satisfied and consistent with the
best interests of the Company.  All options granted to executive  officers under
such plan after January 1, 1996 are eligible for treatment as "performance-based
compensation."

Key Elements of Executive Compensation

         The Company's executive compensation program is designed to attract and
retain executives capable of leading the Company to meet its business objectives
and to motivate them to enhance long-term stockholder value. The key elements of
the program are competitive pay and equity incentives.  Annual  compensation for
the Company's  executive officers consists of three elements:  a base salary, an
incentive bonus and stock option grants.

         The Committee makes compensation determinations based upon a subjective
assessment of a variety of factors,  both personal and corporate,  in evaluating
the  performance  of the Company's  executive  officers and making  compensation
decisions.  These factors include,  in order of importance,  the progress of the
Company toward its long-term  objectives,  the individual  contributions of each
officer to the  Company,  and the  compensation  paid by selected  biotechnology
companies to individuals in comparable  positions.  The Committee's  weighing of
these factors in determining the compensation of an individual executive officer
may vary. In awarding  stock  options,  the  Committee  considers the number and
value of an executive officer's outstanding stock options.

     In  light  of the  Company's  disappointing  test  results  and the loss of
collaborative  partner support,  the measures presently used by the Committee in
evaluating  the  Company's  progress  are  management's  ability to  effectively
implement the Board of Director's  restructuring and cost-saving policies, which
include  (i)  reducing  the  Company's  work  force,  (ii)  decommissioning  the
Company's laboratories, and (iii) selling the Company's scientific and technical
equipment,  as  well  as  management's  ability  to  efficiently  use  corporate
resources.  Historically,  the Committee has considered,  and where  appropriate
will continue to consider,  (w) the  achievement  and  management of appropriate
collaborative   arrangements  with  larger   pharmaceutical   and  biotechnology
companies  relating  to  the  discovery  and  development  of   commercializable
products,  (x) progress of products under  development in pre-clinical  (animal)
testing,  (y) the effectiveness  with which management  identifies new strategic
alternatives  and  its  responses  to new  information  such as the  results  of
research programs and clinical trials in the context of the identified strategic
alternatives, and (z) the hiring and retention of subordinate officers and other
key employees best capable of accomplishing the foregoing.

         Base Salary. When utilizing comparative data, the Committee attempts to
set  compensation  levels in the  mid-range of  management  compensation  at the
companies  examined.  In December  1996, the  Compensation  Committee set annual
salaries for 1997.  The  Compensation  Committee  reviews  salaries on an annual
basis,  with the annual review for 1998 having  occurred in December 1997. At an
annual review, the Compensation  Committee may increase each executive officer's
salary based on the individual's  contributions  and  responsibilities  over the
prior 12 months and expectations for the next 12 months.

         Bonus.  The  Committee  may award bonuses at the end of the fiscal year
based on the Company's ability to meet its corporate and strategic goals and the
individual's  contributions  to those  goals,  if it  deems  such an award to be
appropriate.  Based on management's ability to effectively implement the Board's
restructuring  policies within a relatively  short period of time, the Committee
decided to award cash bonuses for 1997 to certain  officers  and key  employees.
[consider providing details,  e.g., number of employees  terminated or amount of
assets sold in 1997.)

         Stock Options.  Long-term  incentives are provided by means of periodic
grants  of  stock  options.   The  Company's  1993  Equity   Incentive  Plan  is
administered  by the  Compensation  Committee.  The  Committee  believes that by
granting executive officers an opportunity to obtain and increase their personal
ownership of Company stock,  the best interests of  stockholders  and executives
will be more closely integrated. The vesting provisions of the option plan serve
to retain  qualified  employees,  providing  continuing  benefits to the Company
beyond those achieved in the year of grant.

Chief Executive Officer Compensation

         Compensation  paid during 1997 to Kenneth R. Lynn, the Company's former
Chief Executive  Officer,  was determined based on a subjective  analysis of the
criteria  described above and reflected the Company's  strategic  challenges for
the coming year,  including its need to significantly  reduce costs and conserve
cash,  while at the same time  pursuing  new  collaborative  relationships  with
larger biotechnology and pharmaceutical  companies, and the desire to compensate
the  chief  executive  officer  in the  mid-range  of  comparable  biotechnology
companies,  based  upon  an  industry  survey  covering  107  biotechnology  and
biopharmaceutical firms with between 51 and 149 employees.

         The foregoing report has been furnished by the  Compensation  Committee
of the Board of Directors and shall not be deemed  incorporated  by reference by
any general  statement  incorporating by reference this proxy statement into any
filing under the Securities Act of 1933 or under the Securities  Exchange Act of
1934, except to the extent the Company specifically  incorporates this report by
reference and shall not otherwise be deemed filed under such Acts.

                                            Respectfully submitted,

                                            Bert Fingerhut


                     STOCK PRICE PERFORMANCE GRAPH

         The following  graph  illustrates a comparison of the cumulative  total
stockholder  return  (change in stock price plus  reinvested  dividends)  of the
Company's Common Stock with the Nasdaq Stock Market (US) (the "Nasdaq US Index")
and the Hambrecht & Quist "Biotechnology Index" (the "H&Q Biotechnology Index").
The  comparisons  in the graph are  required by the SEC and are not  intended to
forecast or be indicative of possible future performance of the Company's Common
Stock.

                        [Stock Performance Graph]


                     12/31/92  12/31/93  12/31/94   12/31/95   12/31/96 12/31/97
Cortech, Inc.        $100.00    127.91     25.29      23.83      13.67      5.53
Nasdaq US Index       100.00    114.80    112.21     158.70     195.19    239.53
H & Q Biotechnology 
Index                 100.00     86.21     81.89     139.30     128.53    130.10

         Assumes a $100 investment on December 31, 1992 in each of the Company's
Common Stock, the securities  comprising the Nasdaq US Index, and the securities
comprising the H&Q Biotechnology Index.


              CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         In February  1992,  Cortech  entered into a series of  agreements  with
CP-0127 Development  Corporation ("CDC") that govern the development of products
utilizing  Bradycor.  The agreements  grant CDC the right to utilize Bradycor in
the United  States,  Canada and Europe for certain  indications,  while  Cortech
retained  rights to such  products in other parts of the world.  Cortech has the
right to market,  sell and  license  the  technology  licensed to CDC or to sell
products  derived  therefrom and is subject to a royalty  obligation in favor of
CDC.
Cortech is not currently developing any compounds covered by the license.

         The Company believes that the foregoing  transactions and relationships
are in its best interests.  As a matter of policy these  transactions  were, and
all future  transactions  between  the Company and its  officers,  directors  or
principal  stockholders  will be,  approved by a majority of the independent and
disinterested  members of the Board of Directors,  on terms no less favorable to
the  Company  than could be  obtained  from  unaffiliated  third  parties and in
connection with bona fide business purposes of the Company.

                           LEGAL PROCEEDINGS

         Biostar Litigation.  On February 27, 1998, a complaint was filed in the
New Castle County,  Delaware Court of Chancery naming the Company, the Company's
directors and BioStar as defendants.  The  complaint,  filed by a stockholder of
the Company, claims to be on behalf of a class of all the Company's stockholders
and contends that the directors of the Company  breached their fiduciary  duties
to the  Company's  stockholders  when they  unanimously  approved  the  proposed
combination with BioStar. The complaint seeks to enjoin the proposed combination
with BioStar as well as the operation of the Company's  stockholder  rights plan
and seeks an order  rescinding  the proposed  combination  with BioStar upon its
consummation as well as  compensatory  damages and costs.  The Company  believes
that the claims are without merit and intends to vigorously  defend against this
suit.  Although there can be no assurances in this regard,  the Company believes
that the suit will have no material  adverse  effect on the Company  because the
Company (i) believes that the claimant will not prevail on the merits,  (ii) has
insurance  which it believes will cover the cost of defending this claim (except
for a $75,000  deductible  amount) and (iii) has terminated the agreement  which
provided for the proposed combination with BioStar.

         AVF  Litigation.  AVF filed an action on June 29,  1998 in the Court of
Chancery  of the State of  Delaware  to  compel  the  Company  to hold an annual
meeting of  stockholders  immediately.  Pursuant to a stipulation  order entered
into by the Company and AVF on July 16,  1998,  and  approved by the Court,  the
Company and AVF agreed and stipulated that the Company's annual meeting would be
held on September 4, 1998 with the record date set for July 10, 1998.


                             STOCKHOLDER PROPOSALS

         To be considered for inclusion in the proxy statement for  presentation
at the Annual Meeting of Stockholders to be held in 1999, a stockholder proposal
must be received  at the  offices of the  Company,  6850 N.  Broadway,  Suite G,
Denver, CO 80221 not later than April 10, 1999.


                                SOLICITATION

     The Company will bear the entire cost of solicitation of proxies, including
preparation,  assembly,  printing and mailing of this proxy statement, the proxy
and any additional information furnished to stockholders. Copies of solicitation
materials  will  be  furnished  to  banks,  brokerage  houses,  fiduciaries  and
custodians  holding in their names shares of Common Stock  beneficially owned by
others to forward to such beneficial  owners.  The Company may reimburse persons
representing  beneficial  owners of Common  Stock for their costs of  forwarding
solicitation  materials to such  beneficial  owners.  Original  solicitation  of
proxies  by  mail  may  be  supplemented  by  telephone,  telegram  or  personal
solicitation  by directors,  officers or other regular  employees of the Company
or, at the Company's request,  D.F. King & Co., Inc., 77 Water Street, New York,
New York  10008-4495  ("D.F.  King").  D.F.  King has advised  the Company  that
approximately 25 D.F. King employees will provide  assistance in connection with
the solicitation. No additional compensation will be paid to directors, officers
or other regular employees for such services,  but D.F. King will be paid a fee,
estimated to be up to approximately  $47,500 (of which $17,500 is contingent the
results  of the  proxy  contest)  plus  reasonable  expenses,  to  assist in the
solicitation of proxies. The Company estimates that the total amount of expenses
to be  incurred  by it in  connection  with  this  proxy  solicitation  will  be
$135,000, $10,000 of which has been incurred to date.

                            INDEMNIFICATION

         The Company's Certificate and Bylaws provide,  among other things, that
the Company will indemnify each officer or director, under the circumstances and
to the extent provided for therein, for expenses,  damages, judgments, fines and
settlements  he may be required to pay in actions or  proceedings to which he is
or may be made a party by reason of his position as a director, officer or other
agent of the Company,  and otherwise to the full extent permitted under Delaware
law.


              SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Section  16(a) of the  Securities  Exchange  Act of 1934,  as  amended,
requires the Company's  directors,  executive officers,  and any persons holding
more than 10% of the Company's Common Stock to file initial reports of ownership
and reports of change in ownership of the  Company's  Common Stock with the SEC.
Officers,  directors and greater than ten percent  stockholders  are required by
SEC  regulation  to furnish the Company  with copies of all Section  16(a) forms
they file.

         To the Company's  knowledge,  based solely on a review of the copies of
such reports furnished to the Company and written  representations that no other
reports were  required,  during the fiscal year ended  December  31,  1997,  all
Section 16(a) filing  requirements  applicable  to its  officers,  directors and
greater than ten percent beneficial owners were complied with.


                                OTHER MATTERS

         The  Board  of  Directors  knows  of no  other  business  that  will be
presented  at the Annual  Meeting.  If any other  matters are  properly  brought
before the Annual Meeting, it is intended that proxies in the enclosed form will
be voted in accordance with the judgment of the persons voting the proxies.

         Any  stockholder  or  stockholder's  representative  who,  because of a
disability,  may need special assistance or accommodation to allow him or her to
participate  at  the  Annual  Meeting  may  request  reasonable   assistance  or
accommodation  from the Company by contacting  Cortech,  Inc., 6850 N. Broadway,
Suite G, Denver,  CO 80221,  (303) 650-1200.  To provide the Company  sufficient
time to arrange for reasonable  assistance or  accommodation,  please submit all
requests by August 25, 1998.

         If you have any questions  concerning  this proxy  solicitation  of the
procedures to execute and deliver a proxy, please contact D.F. King at:

                             D.F. King & Co., Inc.
                                77 Water Street
                         New York, New York 10005-4495
                                  (212) 249-5550

         Whether you intend to be present at the Annual  Meeting or not, we urge
you to return your signed WHITE-STRIPED proxy card promptly.

                       By order of the Board of Directors


                                            Bert Fingerhut
                                            Chairman


<PAGE>


                                  CORTECH, INC.
                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                         TO BE HELD ON SEPTEMBER 4, 1998

         The undersigned hereby appoints Bert Fingerhut, Diarmuid Boran and John
Cheronis,  M.D., and each of them, as attorneys and proxies of the  undersigned,
with full power of  substitution,  to vote all of the shares of Common  Stock of
Cortech,  Inc. (the "Company")  which the undersigned may be entitled to vote at
the Annual Meeting of  Stockholders of the Company to be held at the Renaissance
Hotel,  3801 Quebec Street,  Denver,  Colorado on Friday,  September 4, 1998, at
9:00 a.m.,  local  time,  and at any and all  postponements,  continuations  and
adjournments  thereof,  with all powers that the  undersigned  would  possess if
personally  present,  upon  and in  respect  of  the  following  matters  and in
accordance with the following  instructions,  with discretionary authority as to
any and all other matters that may properly come before the meeting.

         UNLESS A CONTRARY DIRECTION IS INDICATED,  THIS PROXY WILL BE VOTED FOR
THE NOMINEES LISTED IN PROPOSAL 1, FOR PROPOSALS 2, 3 AND 5 AND AGAINST PROPOSAL
4, ALL AS MORE  SPECIFICALLY  DESCRIBED  IN THE  PROXY  STATEMENT.  IF  SPECIFIC
INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.

PROPOSAL 1: ELECTION OF DIRECTORS

         The Board of  Directors  recommends  a vote FOR the  Nominee(s)  listed
below.

o  FOR the nominee(s) listed below       o  WITHHOLD AUTHORITY to vote for      
  (except as marked to the contrary below). the nominee(s) listed below.

         NOMINEE:

         __________________________          (Class I Director)
         __________________________          (Class I Director)*
         __________________________          (Class I Director)*
         __________________________          (Class III Director)*

- ----
* Nominated for election  solely in the event Proposal 4 to increase the size of
  the Board, which is opposed by the Board of Directors, is approved.


TO WITHHOLD AUTHORITY TO VOTE FOR ANY NOMINEE WRITE SUCH NOMINEE'S NAME BELOW

- ---------------------------------------------------

(CONTINUED AND TO BE SIGNED ON OTHER SIDE)


<PAGE>





PROPOSAL  2:  To  approve  an  amendment  to  the   Company's   Certificate   of
Incorporation which provides for a one-for-[four] reverse stock split.

o FOR         o AGAINST        o  ABSTAIN

The Board of Directors recommends a vote FOR Proposal 2.

PROPOSAL  3: To amend  Article IX,  Section 1 of the  Company's  Certificate  of
Incorporation  to provide that the number of directors shall be set by the Board
of Directors.

o FOR         o AGAINST        o  ABSTAIN

The Board of Directors recommends a vote FOR Proposal 3.

PROPOSAL 4: To amend Article 3, Section 3.1 of the Company's  By-laws to set the
number of directors to serve on the Board of Directors at seven.

o FOR         o AGAINST        o  ABSTAIN

The Board of Directors recommends a vote AGAINST Proposal 4.

PROPOSAL  5: To ratify  the  selection  of Arthur  Andersen  LLP as  independent
auditors of the Company for its fiscal year ending December 31, 1998.

o FOR         o AGAINST        o  ABSTAIN

The Board of Directors recommends a vote FOR Proposal 5.

         DATE: _________________________, 1998

         ------------------------------------
         SIGNATURE(S)

         ------------------------------------
         TITLE (IF APPLICABLE)

         Please  sign  exactly  as your  name  appears  hereon.  If the stock is
         registered  in the  names of two or more  persons,  each  should  sign.
         Executors,  administrators,  trustees,  guardians and attorneys-in-fact
         should add their titles.  If signer is a corporation,  please give full
         corporate name and have a duly authorized  officer sign, stating title.
         If  signer  is a  partnership,  please  sign  in  partnership  name  by
         authorized person.

PLEASE  VOTE,  DATE AND PROMPTLY  RETURN THIS PROXY CARD IN THE ENCLOSED  RETURN
ENVELOPE WHICH IS POSTAGE PREPAID IF MAILED IN THE UNITED STATES.


<PAGE>


                   BARTLIT BECK HERMAN PALENCHAR & SCOTT
                         The Kittredge Building
                          511 Sixteenth Street
                            Denver, CO 80202

July 24, 1998



Securities and Exchange Commission
Judiciary Plaza
450 Fifth Street, N.W.
Washington, D.C.  20549

         Re:      Cortech, Inc.

Dear Sir or Madam:

         On behalf of Cortech, Inc., a Delaware corporation (the "Company"),  we
hereby  electronically  transmit,  pursuant to Regulation S-T promulgated by the
Securities  and Exchange  Commission,  the  preliminary  Proxy  Statement of the
Company in respect of its annual meeting to be held on September 4, 1998.  Asset
Value Fund  Limited  Partnership,  a  stockholder  of the  Company,  has filed a
preliminary proxy statement in opposition to the solicitation by the Company.

         Please contact the  undersigned at (303) 592-3175 or Thomas R. Stephens
of this firm at (303) 592-3144  should you require  further  information or have
any additional questions.



                                       Very truly yours,

                                       /s/ Polly S. Swartzfager

                                       Polly S. Swartzfager
                                       (Admitted in New York;
                                       application pending in Colorado)



PSS/kmv





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