MERRILL LYNCH PIERCE FENNER & SMITH INC
8-A12B, 1999-11-23
ASSET-BACKED SECURITIES
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<PAGE>

                                    FORM 8-A

                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549


               FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
                    PURSUANT TO SECTION 12(b) OR (g) OF THE
                        SECURITIES EXCHANGE ACT OF 1934

                            Biotech HOLDRs/SM/ Trust
             (Exact name of registrant as specified in its charter)


                 New York                               not applicable
   (State of incorporation or organization)            (I.R.S. Employer
                                                      Identification No.)
      c/o The Bank of New York, as Trustee
           101 Barclay Street, 22-W
              New York, New York                           10286
   (Address of principal executive offices)              (Zip Code)

   Securities to be registered pursuant to Section 12(b) of the Act:

     Title of each class                      Name of each exchange on which
     to be so registered:                     each class is to be registered:

        Biotech HOLDRs                            American Stock Exchange


     If this form relates to the registration of a class of securities pursuant
to Section 12(b) of the Exchange Act and is effective pursuant to General
Instruction A.(c), check the following box. [x]

     If this form relates to the registration of a class of securities pursuant
to Section 12(g) of the Exchange Act and is effective pursuant to General
Instruction A.(d), check the following box. [ ]

     Securities Act registration file number to which this form relates:

     333-89355

     Securities to be registered pursuant to Section 12(g) of the Act:

                                      None
<PAGE>

                                       2

                 INFORMATION REQUIRED IN REGISTRATION STATEMENT

Item 1.   Description of Registrant's Securities to be Registered.

     The description of the 1,000,000,000 Depositary Receipts to be issued by
the Biotech HOLDRs Trust (the "Biotech HOLDRs") to be registered hereunder is
set forth under the caption entitled "Description of Biotech HOLDRs" in the
prospectus dated November 22, 1999, which description is hereby incorporated by
reference.  The prospectus was filed with the Securities and Exchange Commission
pursuant to Rule 424(b)(2) of the Securities Act of 1933 on November 23, 1999.

Item 2.   Exhibits.

     1. Form of Depositary Trust Agreement is set forth in Exhibit 4.1 to the
        registrant's Registration Statement on Form S-1 (Registration No.
        333-89355) (the "Registration Statement") and is incorporated herein by
        reference.

     2. Form of Biotech HOLDRs is set forth in Exhibit 4.1 to the Registration
        Statement and is incorporated herein by reference.
<PAGE>

                                   SIGNATURE

          Pursuant to the requirements of Section 12 of the Securities Exchange
Act of 1934, the registrant has duly caused this registration statement to be
signed on its behalf by the undersigned, thereto duly authorized.

                                          MERRILL LYNCH, PIERCE, FENNER & SMITH
                                           INCORPORATED, as Initial Depositor,
                                                        on behalf of
                                                    Biotech HOLDRS Trust


Date:  November 23, 1999                    By: /s/ STEPHEN G. BODURTHA
                                                ----------------------------
                                                Name: Stephen G. Bodurtha
                                                Title: Attorney-in-Fact


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