MERRILL LYNCH PIERCE FENNER & SMITH INC
424B4, 2000-02-01
ASSET-BACKED SECURITIES
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<PAGE>

                                           FILED PURSUANT TO RULE NO. 424(B)(4)
                                           REGISTRATION NO. 333-92161
                                           REGISTRATION NO. 333-95805



PROSPECTUS
                      [LOGO OF PHARMACEUTICAL HOLDRs SM]

                       1,000,000,000 Depositary Receipts
                        Pharmaceutical HOLDRs SM Trust

     The Pharmaceutical HOLDRsSM Trust will issue Depositary Receipts called
Pharmaceutical HOLDRsSM representing your undivided beneficial ownership in
the U.S.-traded common stock of a group of 20 specified companies that are
involved in various segments of the pharmaceutical industry. The Bank of New
York will be the trustee. You only may acquire, hold or transfer
Pharmaceutical HOLDRs in a round-lot amount of 100 Pharmaceutical HOLDRs or
round-lot multiples. Pharmaceutical HOLDRs are separate from the underlying
deposited common stocks that are represented by the Pharmaceutical HOLDRs. For
a list of the names and the number of shares of the companies that make up a
Pharmaceutical HOLDR, see "Highlights of Pharmaceutical HOLDRs--The
Pharmaceutical HOLDRs" starting on page 9. Merrill Lynch, Pierce, Fenner &
Smith Incorporated has sold 6,812,000 Pharmaceutical HOLDRs in the initial
distribution. The trust will issue the additional Pharmaceutical HOLDRs on a
continuous basis after the initial distribution.

     Investing in Pharmaceutical HOLDRs involves significant risks. See "Risk
factors" starting on page 4.

     The initial public offering price for a round-lot of 100 Pharmaceutical
HOLDRs will equal the sum of the closing market price on the primary trading
market on January 31, 2000 for each deposited share multiplied by the share
amount specified in this prospectus, plus an underwriting fee.

     Pharmaceutical HOLDRs are neither interests in nor obligations of either
the initial depositor, Merrill Lynch, Pierce, Fenner & Smith Incorporated, or
The Bank of New York, as trustee.

     Prior to this issuance, there has been no public market for
Pharmaceutical HOLDRs. The Pharmaceutical HOLDRs have been approved for
listing on the American Stock Exchange under the symbol "PPH", subject to
official notice of issuance.

                                ---------------

     Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved these securities or determined if this
prospectus is truthful or complete. Any representation to the contrary is a
criminal offense.

<TABLE>
<CAPTION>
                                                      Initial Price Underwriting
                                                       to Public*       Fee
                                                      ------------- ------------
     <S>                                              <C>           <C>
     Per Pharmaceutical HOLDR........................    $93.72           2%
</TABLE>
    -------
     * Includes underwriting fee.

     For purchases of Pharmaceutical HOLDRs in excess of 10,000 Pharmaceutical
HOLDRs, the underwriting fee will be 1.5%.

                                ---------------

                              Merrill Lynch & Co.

                                ---------------

               The date of this prospectus is January 31, 2000.

"HOLDRs" and "HOLding Company Depositary Receipts" are service marks of
Merrill Lynch & Co., Inc.
<PAGE>

                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                            Page
                                                                            ----
<S>                                                                         <C>
Summary....................................................................   3
Risk Factors...............................................................   4
Highlights of Pharmaceutical HOLDRs........................................   9
The Trust..................................................................  15
Description of Pharmaceutical HOLDRs.......................................  15
Description of the Underlying Securities...................................  16
Description of the Depositary Trust Agreement..............................  18
Federal Income Tax Consequences............................................  21
ERISA Considerations.......................................................  22
Plan of Distribution.......................................................  22
Legal Matters..............................................................  23
Where You Can Find More Information........................................  23
</TABLE>

                               ----------------

      This prospectus contains information you should consider when making your
investment decision. With respect to information about Pharmaceutical HOLDRs,
you should rely only on the information contained in this prospectus. We have
not authorized any other person to provide you with different information. If
anyone provides you with different or inconsistent information, you should not
rely on it. We are not making an offer to sell Pharmaceutical HOLDRs in any
jurisdiction where the offer or sale is not permitted.

                                       2
<PAGE>

                                    SUMMARY

     The Pharmaceutical HOLDRs trust will be formed under the depositary trust
agreement, dated as of January 24, 2000 among The Bank of New York, as
trustee, Merrill Lynch, Pierce, Fenner & Smith Incorporated, other depositors
and the owners of the Pharmaceutical HOLDRs. The trust is not a registered
investment company under the Investment Company Act of 1940.

     The trust will hold shares of common stock issued by 20 specified
companies generally considered to be involved in various segments of the
pharmaceutical industry. The number of shares of each common stock held by the
trust with respect to each round-lot of Pharmaceutical HOLDRs is specified
under "Highlights of Pharmaceutical HOLDRs-The Pharmaceutical HOLDRs." This
group of common stocks is referred to as the underlying securities. Except
when a reconstitution event occurs, the underlying securities will not change.

     Under no circumstances will a new company be added to the group of
issuers of underlying securities.

     The trust will issue Pharmaceutical HOLDRs that represent your undivided
beneficial ownership interest in the shares of common stock held by the trust
on your behalf. The Pharmaceutical HOLDRs are separate from the underlying
common stocks that are represented by the Pharmaceutical HOLDRs.

                                       3
<PAGE>

                                  RISK FACTORS

      An investment in Pharmaceutical HOLDRs involves risks similar to
investing in each of the underlying securities outside of the Pharmaceutical
HOLDRs, including the risks associated with concentrated investments in the
pharmaceutical industry.

General Risk Factors

     .  Loss of investment. Because the value of Pharmaceutical HOLDRs
        directly relates to the value of the underlying securities, you
        may lose all or a substantial portion of your investment in the
        Pharmaceutical HOLDRs if the underlying securities decline in
        value.

     .  Discount trading price. Pharmaceutical HOLDRs may trade at a
        discount to the aggregate value of the underlying securities.

     .  Not necessarily representative of the pharmaceutical
        industry. While the underlying securities are common stocks of
        companies generally considered to be involved in various segments
        of the pharmaceutical industry, the underlying securities and the
        Pharmaceutical HOLDRs may not necessarily follow the price
        movements of the entire pharmaceutical industry generally. If the
        underlying securities decline in value, your investment in the
        Pharmaceutical HOLDRs will decline in value even if common stock
        prices in the pharmaceutical industry generally increase in value.
        Furthermore, after the initial deposit, one or more of the issuers
        of the underlying securities may no longer be involved in the
        pharmaceutical industry. In this case, the Pharmaceutical HOLDRs
        may no longer consist of securities issued only by companies
        involved in the pharmaceutical industry.

     .  No investigation of underlying securities. The underlying
        securities included in the Pharmaceutical HOLDRs were selected by
        Merrill Lynch, Pierce, Fenner & Smith Incorporated based on the
        market capitalization of issuers and the market liquidity of
        common stocks in the pharmaceutical industry, without regard for
        the value, price performance, volatility or investment merit of
        the underlying securities. The Pharmaceutical HOLDRs Trust, the
        trustee, Merrill Lynch, Pierce, Fenner & Smith Incorporated, and
        their affiliates, have not performed any investigation or review
        of the selected companies, including the public filings by the
        companies. Investors and market participants should not conclude
        that the inclusion of a company is any form of investment
        recommendation by the trust, the trustee, Merrill Lynch, Pierce,
        Fenner & Smith Incorporated, or their affiliates.

     .  Loss of diversification. As a result of business developments,
        reorganizations, or market fluctuations affecting issuers of the
        underlying securities, Pharmaceutical HOLDRs may not necessarily
        continue to be a diversified investment in the pharmaceutical
        industry. As a result of market fluctuation and/or reconstitution
        events, Pharmaceutical HOLDRs may represent a concentrated
        investment in one or more of the underlying securities which would
        reduce investment diversification and increase your exposure to
        the risks of concentrated investments.

     .  Conflicting investment choices. In order to sell one or more of
        the underlying securities individually or to participate in a
        tender offer relating to one or more of the underlying securities,
        you will be required to cancel your Pharmaceutical HOLDRs and
        receive delivery of each of the underlying securities. The
        cancellation of your Pharmaceutical HOLDRs will allow you to sell
        individual underlying securities or to deliver individual
        underlying securities in a tender offer. If you choose not to
        cancel your Pharmaceutical HOLDRs you cannot participate in a
        tender offer relating to an underlying security. The cancellation
        of Pharmaceutical HOLDRs will involve payment of a cancellation
        fee to the trustee.

                                       4
<PAGE>

        Currently some of the underlying securities of the Pharmaceutical
        HOLDRs are the subject of, or are involved in, a tender offer. For
        example: (1) Pfizer Inc. filed on November 15, 1999 a registration
        statement on Form S-4 in an effort to acquire the outstanding
        shares of common stock of Warner-Lambert Company and (2) American
        Home Products Corporation has entered into an Agreement and Plan
        of Merger with Warner-Lambert Company and on December 20, 1999,
        filed a registration statement on Form S-4 whereby each
        outstanding share of Warner-Lambert common stock will convert into
        shares of AmericanWarner common stock. There are no assurances
        that either of these tender offers will be completed. For more
        detail on the underlying securities mentioned above, see "Annex
        A." In addition, it is likely that other tender offers for some of
        the underlying securities of the Pharmaceutical HOLDRs will be
        made in the future.

     .  Trading halts. Trading in Pharmaceutical HOLDRs may be halted in
        the event trading in one or more of the underlying securities is
        halted. If so, you will not be able to trade Pharmaceutical HOLDRs
        even though there is trading in some of the underlying securities,
        however, you will be able to cancel your Pharmaceutical HOLDRs to
        receive the underlying securities.

     .  Delisting from the American Stock Exchange. If the number of
        companies whose common stock is held in the trust falls below
        nine, the American Stock Exchange may consider delisting the
        Pharmaceutical HOLDRs. If the Pharmaceutical HOLDRs are delisted
        by the American Stock Exchange, a termination event will result if
        the Pharmaceutical HOLDRs are not listed for trading on another
        national securities exchange or through NASDAQ within five
        business days from the date the Pharmaceutical HOLDRs are
        delisted.

     .  Possible conflicts of interest. Merrill Lynch, Pierce, Fenner &
        Smith Incorporated, as initial depositor, has selected the
        underlying securities and may face possible conflicts of interest
        in connection with its activities. For example, Merrill Lynch,
        Pierce, Fenner & Smith Incorporated and its affiliates,
        collectively referred to as Merrill Lynch, may engage in
        investment banking and other activities, may provide services to
        issuers of the underlying securities in connection with its
        business, or may trade in the underlying securities for its own
        account. All of these activities may result in conflicts of
        interest with respect to the financial interest of Merrill Lynch,
        on the one hand, and, on the other hand, the initial selection of
        the underlying securities included in the Pharmaceutical HOLDRs,
        the selection of the pharmaceutical industry, Merrill Lynch's
        activity in the secondary market in the underlying securities, and
        the creation and cancellation of Pharmaceutical HOLDRs by Merrill
        Lynch.

     .  Temporary price increases in the underlying securities. Purchasing
        activity in the secondary trading market associated with acquiring
        the underlying securities for deposit into the trust may affect
        the market price of the deposited shares. Large volumes of
        purchasing activity, which may occur in connection with the
        issuance of Pharmaceutical HOLDRs, particularly in connection with
        the initial issuance of Pharmaceutical HOLDRs, could temporarily
        increase the market price of the underlying securities, resulting
        in a higher price on that date. This purchasing activity could
        create a temporary imbalance between the supply and demand of the
        underlying securities, thereby limiting the liquidity of the
        underlying securities due to a temporary increased demand for
        underlying securities. Consequently, prices for the underlying
        securities may decline after these purchases as the volume of
        purchases subsides. This in turn is likely to have an immediate,
        adverse effect on the trading price of Pharmaceutical HOLDRs.

                                       5
<PAGE>

Risk Factors Specific to the Pharmaceutical Industry

     .  Pharmaceutical company stock prices have been and will likely
        continue to be extremely volatile. Pharmaceutical companies stock
        prices could be subject to wide fluctuations in response to a
        variety of factors, including:

            .  announcements of technological innovations or new commercial
               products;

            .  developments in patent or proprietary rights;

            .  government regulatory initiatives;

            .  public concern as to the safety or other implications of
               pharmaceutical products;

            .  fluctuations in quarterly and annual financial results; and

            .  market conditions.

     .  Pharmaceutical companies face uncertainty with respect to pricing
        and third party reimbursement. The ability of many pharmaceutical
        companies to commercialize current and any future products depends
        in part on the extent to which reimbursement for the cost of such
        products and related treatments are available from government
        health agencies, private health insurers and other third-party
        payors. Third-party payors are increasingly challenging the price
        and cost-effectiveness of medical products. Significant
        uncertainty exists as to the reimbursement status of health care
        products, and there can be no assurance that adequate third-party
        coverage will be available for pharmaceutical companies to obtain
        satisfactory price levels for their products. Government and other
        third-party payors are increasingly attempting to contain health
        care costs by a variety of means, including limiting both the
        degree of coverage and the level of reimbursement for new
        therapeutic products. If pharmaceutical companies do not obtain
        adequate coverage and reimbursement levels from government and
        third-party payors for use of existing and potential products, the
        costs and market acceptance of their products could be adversely
        affected.

     .  Protection of patent and proprietary rights of pharmaceutical
        companies is difficult and costly. The success of many
        pharmaceutical companies is highly dependent on their ability to
        obtain patents, to defend their existing patents and trade secrets
        and to operate in a manner that does not infringe the proprietary
        rights of other pharmaceutical companies. Patent disputes are
        frequent and can preclude the successful commercial introduction
        of products and technologies. As a result, there is significant
        litigation in the pharmaceutical industry regarding patent and
        other intellectual property rights. Litigation is costly, diverts
        resources and can subject a pharmaceutical company to significant
        liabilities to third parties. In addition, a pharmaceutical
        company could be forced to obtain costly third-party licenses or
        cease using the technology or product in dispute.

     .  Many pharmaceutical companies face intense competition from new
        products and less costly generic products. The pharmaceutical
        industry is highly competitive and rapidly changing. Many
        pharmaceutical companies are major international corporations with
        substantial resources for research and development, production and
        marketing. Proprietary pharmaceutical products, which are products
        under patent protection, face intense competition from other
        competitors' similar proprietary products and many pharmaceutical
        companies also face increasing competition from similar generic
        products. Generic pharmaceutical competitors generally are able to
        obtain regulatory approval for drugs no longer covered by patents
        without investing in costly and time-consuming clinical trials,
        and need only demonstrate that their product is equivalent to the
        drug they wish to copy. As a result of their substantially reduced
        developments costs, generic pharmaceutical products are sold at
        lower prices than the original proprietary product. The
        introduction of a generic product can significantly reduce
        revenues received from a patented pharmaceutical product.

                                       6
<PAGE>

     .  Research and development efforts may not result in successful
        products. A pharmaceutical company's success depends on its
        ability to commit substantial resources to research and
        development and to obtain regulatory approval to market new
        pharmaceutical products. Development of a product requires
        substantial technical, financial and human resources and the
        research and development process often takes 10 or more years from
        discovery to commercial product launch. This process is conducted
        in various stages, and during each stage there is a substantial
        risk that a pharmaceutical company will not achieve its goals and
        will have to abandon a product in which it has invested
        substantial amounts. A pharmaceutical company may choose product
        candidates that are unsuccessful, unable to be developed in a
        timely manner or that require excessive resources to bring to
        market. Delays or unanticipated increases in costs of development
        at any stage of development, or failure to obtain regulatory
        approval or market acceptance of products could adversely affect a
        pharmaceutical company's results and financial condition.

     .  Pharmaceutical companies must keep pace with rapid technological
        change to remain competitive. The pharmaceutical industry is
        highly competitive and is subject to rapid and significant
        technological change. The success of a pharmaceutical company will
        depend in large part on its ability to maintain a competitive
        position, measured largely by the effectiveness and marketing of
        its products. Any technological advancement, product or process
        that these companies develop may become obsolete before research
        and development expenses are recovered.

     .  Pharmaceutical companies are subject to extensive government
        regulation. Pharmaceutical products offered by pharmaceutical
        companies are subject to strict regulation by governmental
        regulatory authorities in countries throughout the world. Products
        require extensive pre-clinical testing and other testing, clinical
        trials, government review and final approval before any marketing
        of the products will be permitted. This procedure could take a
        number of years and involves the expenditure of substantial
        resources. The success of a pharmaceutical company's products will
        depend, in part, upon obtaining and maintaining regulatory
        approval to market products and, once approved, complying with the
        continued review by regulatory agencies. For instance, the Food
        and Drug Administration (FDA), the agency which regulates and
        investigates drugs in the United States, can take as long as eight
        to nine years after an application is originally filed to approve
        a new drug application. The manufacturing process for
        pharmaceutical products is also highly regulated and
        pharmaceutical companies are subjected to periodic inspection of
        manufacturing facilities by regulatory agencies in many countries.
        Regulatory agencies may shut down manufacturing facilities that
        they find do not comply with regulations. The failure to obtain
        necessary government approvals, the restriction of existing
        approvals, loss of or changes to previously obtained approvals or
        the failure to comply with regulatory requirements could result in
        fines, unanticipated expenditures, product delays, non-approval or
        recall, interruption of production and even criminal prosecution.

     .  Pharmaceutical companies may be exposed to extensive product
        liability costs. Product liability is a significant commercial
        risk for many pharmaceutical companies. Substantial damage awards
        have been granted in several jurisdiction against pharmaceutical
        companies based upon claims for injuries allegedly caused by the
        use of their products. Many pharmaceutical companies obtain
        product liability insurance; however, a single product liability
        claim could exceed the coverage limits of a pharmaceutical
        company. Further, there can be no assurance that a pharmaceutical
        company will be able to obtain or maintain its product liability
        insurance, that it will continue to be able to obtain adequate
        product liability insurance on reasonable terms or that any
        product liability insurance obtained will provide adequate
        coverage against potential liabilities. The business, financial
        condition and results of operations of a pharmaceutical company
        could be materially and adversely affected by one or more
        successful product liability claims.

                                       7
<PAGE>

     .  Many pharmaceutical companies are dependent on key personnel for
        success. The success of many pharmaceutical companies is highly
        dependent on the experience, abilities, and continued services of
        key executive officers and key scientific and technical personnel.
        If these companies lose the services of any of these officers or
        key scientific and technical personnel, their future success could
        be undermined. The success of many pharmaceutical companies also
        depends upon their ability to attract and retain other highly
        qualified scientific, technical, sales and manufacturing personnel
        and their ability to develop and maintain relationships with
        qualified clinical researchers. Competition for such personnel and
        relationships is intense and many of these companies compete with
        each other and with universities and non-profit research
        organizations. There is no certainty that any of these
        pharmaceutical companies will be able to continue to attract and
        retain qualified personnel or develop and maintain relationships
        with clinical researchers.

                                       8
<PAGE>

                      HIGHLIGHTS OF PHARMACEUTICAL HOLDRs

      This discussion highlights information regarding Pharmaceutical HOLDRs;
we present certain information more fully in the rest of this prospectus. You
should read the entire prospectus carefully before you purchase Pharmaceutical
HOLDRs.

Issuer.......................  Pharmaceutical HOLDRs Trust.

The trust....................  The Pharmaceutical HOLDRs Trust will be formed
                               under the depositary trust agreement, dated as
                               of January 24, 2000 among The Bank of New York,
                               as trustee, Merrill Lynch, Pierce, Fenner &
                               Smith Incorporated, other depositors and the
                               owners of the Pharmaceutical HOLDRs. The trust
                               is not a registered investment company under
                               the Investment Company Act of 1940.

Initial depositor............
                               Merrill Lynch, Pierce, Fenner & Smith
                               Incorporated.

Trustee......................  The Bank of New York, a New York state-
                               chartered banking organization, will be the
                               trustee and receive compensation as set forth
                               in the depositary trust agreement.

Purpose of Pharmaceutical
 HOLDRs......................  Pharmaceutical HOLDRs are designed to achieve
                               the following:

                               Diversification. Pharmaceutical HOLDRs are
                               designed to allow you to diversify your
                               investment in the pharmaceutical industry
                               through a single, exchange-listed instrument
                               representing your undivided beneficial
                               ownership of the underlying securities.

                               Flexibility. The beneficial owners of
                               Pharmaceutical HOLDRs have undivided beneficial
                               ownership interests in each of the underlying
                               securities represented by the Pharmaceutical
                               HOLDRs, and can cancel their Pharmaceutical
                               HOLDRs to receive each of the underlying
                               securities represented by the Pharmaceutical
                               HOLDRs.

                               Transaction costs. The expenses associated with
                               trading Pharmaceutical HOLDRs are expected to
                               be less than trading each of the underlying
                               securities separately.

Trust assets.................  The trust will hold shares of common stock
                               issued by 20 specified companies in the
                               pharmaceutical industry. Except when a
                               reconstitution event occurs, the group of
                               companies will not change. Reconstitution
                               events are described in this prospectus under
                               the heading "Description of the depositary
                               trust agreement-- Reconstitution events." Under
                               no circumstances will the common stock of a new
                               company be added to the common stocks
                               underlying the Pharmaceutical HOLDRs.

                               The trust's assets may increase or decrease as
                               a result of in-kind deposits and withdrawals of
                               the underlying securities during the life of
                               the trust.

                                       9
<PAGE>

The Pharmaceutical HOLDRs....
                               The trust will issue Pharmaceutical HOLDRs that
                               represent your undivided beneficial ownership
                               interest in the shares of U.S.-traded common
                               stock held by the trust on your behalf. The
                               Pharmaceutical HOLDRs themselves are separate
                               from the underlying securities that are
                               represented by the Pharmaceutical HOLDRs.

                               The specific share amounts for each round-lot
                               of 100 Pharmaceutical HOLDRs are set forth in
                               the chart below and were determined on December
                               15, 1999 so that the initial weightings of each
                               underlying security included in the
                               Pharmaceutical HOLDRs approximated the relative
                               market capitalizations of the specified
                               companies, subject to a maximum weight of 20%.
                               Because these weightings are a function of
                               market prices, it is expected that these
                               weightings will change substantially over time,
                               including during the period between December
                               15, 1999 and the date the Pharmaceutical HOLDRs
                               are first issued to the public.

                               The share amounts set forth below will not
                               change, except for changes due to corporate
                               events such as stock splits or reverse stock
                               splits on the underlying securities or
                               reconstitution events.

                               The following chart provides the

                               .  names of the 20 issuers of the underlying
                                  securities represented by the Pharmaceutical
                                  HOLDRs,

                               .  stock ticker symbols,

                               .  share amounts represented by a round-lot of
                                  100 Pharmaceutical HOLDRs,

                               .  initial weightings as of December 15, 1999
                                  and

                               .  principal market on which the shares of
                                  common stock of the selected companies are
                                  traded.

<TABLE>
<CAPTION>
                                                                        Primary
                                                       Share   Initial  Trading
                        Name of Company        Ticker Amounts Weighting Market
                   --------------------------  ------ ------- --------- -------
                   <S>                         <C>    <C>     <C>       <C>
                   Merck & Co., Inc.            MRK      22    17.50%     NYSE
                   Pfizer Inc.                  PFE      36    13.75%     NYSE
                   Johnson & Johnson            JNJ      13    13.72%     NYSE
                   Bristol-Myers Squibb
                    Company                     BMY      18    13.37%     NYSE
                   Eli Lilly & Company          LLY      10     7.63%     NYSE
                   Warner-Lambert Company       WLA       8     7.56%     NYSE
                   Schering-Plough
                    Corporation                 SGP      14     7.04%     NYSE
                   American Home Products
                    Corporation                 AHP      12     6.38%     NYSE
                   Abbott Laboratories          ABT      14     5.45%     NYSE
                   Pharmacia & Upjohn, Inc.     PNU       5     3.02%     NYSE
                   Biovail Corporation
                    International               BVF       2     0.83%     NYSE
                   King Pharmaceuticals, Inc.   KING      1     0.61%   NASDAQ
                   Forest Laboratories, Inc.    FRX       1     0.60%     NYSE
                   Andrx Corporation            ADRX      1     0.48%   NASDAQ
                   Allergan, Inc.               AGN       1     0.47%     NYSE
                   Jones Pharma Inc.            JMED      1     0.45%   NASDAQ
                   Watson Pharmaceuticals,
                    Inc.                        WPI       1     0.40%     NYSE
                   ICN Pharmaceuticals, Inc.    ICN       1     0.27%     NYSE
                   Mylan Laboratories, Inc.     MYL       1     0.25%     NYSE
                   IVAX Corporation(/1/)        IVX       1     0.22%     AMEX
</TABLE>
                               --------
                               (/1/) On February 23, 2000, as a result of a 3-
                                     for-2 stock split, the share amount of
                                     IVAX Corporation, represented by a round-
                                     lot of 100 Pharmaceutical HOLDRs, will be
                                     1.5. Please see the description of IVAX
                                     in Annex A.

                                       10
<PAGE>

                               These companies generally are considered to be
                               among the 20 largest and most liquid companies
                               with U.S.-traded common stock involved in the
                               pharmaceutical industry as measured by market
                               capitalization and trading volume on December
                               15, 1999. The market capitalization of a
                               company is determined by multiplying the price
                               of its common stock by the number of
                               outstanding shares of its common stock.

                               The trust only will issue and cancel, and you
                               only may obtain, hold, trade or surrender,
                               Pharmaceutical HOLDRs in a round-lot of 100
                               Pharmaceutical HOLDRs and round-lot multiples.
                               The trust will only issue Pharmaceutical HOLDRs
                               upon the deposit of the whole shares
                               represented by a round-lot of 100
                               Pharmaceutical HOLDRs. In the event that a
                               fractional share comes to be represented by a
                               round-lot of Pharmaceutical HOLDRs, the trust
                               may require a minimum of more than one round-
                               lot of 100 Pharmaceutical HOLDRs for an
                               issuance so that the trust will always receive
                               whole share amounts for issuance of
                               Pharmaceutical HOLDRs.

                               The number of outstanding Pharmaceutical HOLDRs
                               will increase and decrease as a result of in-
                               kind deposits and withdrawals of the underlying
                               securities. The trust will stand ready to issue
                               additional Pharmaceutical HOLDRs on a
                               continuous basis when an investor deposits the
                               required shares of common stock with the
                               trustee.

Public offering price........  The initial public offering price for 100
                               Pharmaceutical HOLDRs will equal the sum of the
                               closing market price on the primary trading
                               market on January 31, 2000, the pricing date,
                               for each underlying security multiplied by the
                               share amount appearing in the above table, plus
                               an underwriting fee.

Purchases....................
                               After the initial offering, you may acquire
                               Pharmaceutical HOLDRs in two ways:

                               .  through an in-kind deposit of the required
                                  number of shares of common stock of the
                                  underlying issuers with the trustee, or

                               .  through a cash purchase in the secondary
                                  trading market.

Underwriting fees............  If you purchase Pharmaceutical HOLDRs in the
                               initial public offering, you will pay Merrill
                               Lynch, Pierce, Fenner & Smith Incorporated, in
                               its role as underwriter, an underwriting fee
                               equal to:

                               .  For purchases of 10,000 Pharmaceutical
                                  HOLDRs or fewer, 2%.

                               .  For purchases in excess of 10,000
                                  Pharmaceutical HOLDRs, 1.5%.

                               You will not be charged any issuance fee or
                               other sales commission in connection with
                               purchases of Pharmaceutical HOLDRs made in the
                               initial public offering.

                                       11
<PAGE>

Issuance and cancellation
 fees........................  After the initial offering, if you wish to
                               create Pharmaceutical HOLDRs by delivering to
                               the trust the requisite shares of common stock
                               represented by a round-lot of 100
                               Pharmaceutical HOLDRs, The Bank of New York as
                               trustee will charge you an issuance fee of up
                               to $10.00 for each round-lot of 100
                               Pharmaceutical HOLDRs. If you wish to cancel
                               your Pharmaceutical HOLDRs and withdraw your
                               underlying securities, The Bank of New York as
                               trustee will charge you a cancellation fee of
                               up to $10.00 for each round-lot of 100
                               Pharmaceutical HOLDRs.

Commissions..................  If you choose to deposit underlying securities
                               in order to receive Pharmaceutical HOLDRs after
                               the conclusion of the initial public offering,
                               you will not be charged the underwriting fee.
                               However, in addition to the issuance fee
                               charged by the trustee described above, you
                               will be responsible for paying any sales
                               commission associated with your purchase of the
                               underlying securities that is charged by your
                               broker, whether it be Merrill Lynch, Pierce,
                               Fenner & Smith Incorporated or another broker.

Custody fees.................
                               The Bank of New York, as trustee and as
                               custodian, will charge you a quarterly custody
                               fee of $2.00 for each round-lot of 100
                               Pharmaceutical HOLDRs to be deducted from any
                               cash dividend or other cash distributions on
                               underlying securities received by the trust.
                               With respect to the aggregate custody fee
                               payable in any calendar year for each
                               Pharmaceutical HOLDR, the Trustee will waive
                               that portion of the fee which exceeds the total
                               cash dividends and other cash distributions
                               received, or to be received, and payable with
                               respect to such calendar year.

Rights relating to
 Pharmaceutical HOLDRs.......  You have the right to withdraw the underlying
                               securities upon request by delivering a round-
                               lot or integral multiple of a round-lot of
                               Pharmaceutical HOLDRs to the trustee, during
                               the trustee's business hours, and paying the
                               cancellation fees, taxes, and other charges.
                               You should receive the underlying securities no
                               later than the business day after the trustee
                               receives a proper notice of cancellation.

                               The trustee will not deliver fractional shares
                               of underlying securities. To the extent that
                               any cancellation of Pharmaceutical HOLDRs would
                               otherwise require the delivery of a fractional
                               share, the trustee will sell such share in the
                               market and the trust, in turn, will deliver
                               cash in lieu of such share. Except with respect
                               to the right to vote for dissolution of the
                               trust, the Pharmaceutical HOLDRs themselves
                               will not have voting rights.

Rights relating to the
 underlying securities.......  You have the right to:

                               .  Receive all shareholder disclosure
                                  materials, including annual and quarterly
                                  reports, distributed by the issuers of the
                                  underlying securities.


                                       12
<PAGE>

                               .   Receive all proxy materials distributed by
                                  the issuers of the underlying securities and
                                  will have the right to instruct the trustee
                                  to vote the underlying securities or may
                                  attend shareholder meetings yourself.

                               .   Receive dividends and other distributions
                                  on the underlying securities, if any are
                                  declared and paid to the trustee by an
                                  issuer of the underlying securities, net of
                                  any applicable taxes or fees.

                               If you wish to participate in a tender offer
                               for underlying securities, you must obtain the
                               underlying securities by surrendering your
                               Pharmaceutical HOLDRs and receiving all of your
                               underlying securities. For specific information
                               about obtaining your underlying securities, you
                               should read the discussion under the caption
                               "Description of the depositary trust
                               agreement."

Reconstitution events........  A. If an issuer of underlying securities no
                                  longer has a class of common stock
                                  registered under section 12 of the
                                  Securities Exchange Act of 1934, then its
                                  securities will no longer be an underlying
                                  security and the trustee will distribute the
                                  shares of that company to the owners of the
                                  Pharmaceutical HOLDRs.

                               B. If the SEC finds that an issuer of
                                  underlying securities should be registered
                                  as an investment company under the
                                  Investment Company Act of 1940, and the
                                  trustee has actual knowledge of the SEC
                                  finding, then the trustee will distribute
                                  the shares of that company to the owners of
                                  the Pharmaceutical HOLDRs.

                               C. If the underlying securities of an issuer
                                  cease to be outstanding as a result of a
                                  merger, consolidation or other corporate
                                  combination, the trustee will distribute the
                                  consideration paid by and received from the
                                  acquiring company to the beneficial owners
                                  of Pharmaceutical HOLDRs, unless the merger,
                                  consolidation or other corporate combination
                                  is between companies that are already
                                  included in the Pharmaceutical HOLDRs and
                                  the consideration paid is additional
                                  underlying securities. In this case, the
                                  additional underlying securities will be
                                  deposited into the trust.

                               D. If an issuer's underlying securities are
                                  delisted from trading on a national
                                  securities exchange or NASDAQ and are not
                                  listed for trading on another national
                                  securities exchange or through NASDAQ within
                                  5 business days from the date such
                                  securities are delisted, then the trustee
                                  will distribute the shares of that company
                                  to the owners of the Pharmaceutical HOLDRs.

                               If a reconstitution event occurs, the trustee
                               will deliver the underlying security to you as
                               promptly as practicable after the date that the
                               trustee has knowledge of the occurrence of a
                               reconstitution event.

                                       13
<PAGE>

Termination events...........
                               A. The Pharmaceutical HOLDRs are delisted from
                                  the American Stock Exchange and are not
                                  listed for trading on another national
                                  securities exchange or through NASDAQ within
                                  5 business days from the date the
                                  Pharmaceutical HOLDRs are delisted.

                               B. The trustee resigns and no successor trustee
                                  is appointed within 60 days from the date
                                  the trustee provides notice to Merrill
                                  Lynch, Pierce, Fenner & Smith, Incorporated,
                                  as initial depositor, of its intent to
                                  resign.

                               C. 75% of beneficial owners of outstanding
                                  Pharmaceutical HOLDRs vote to dissolve and
                                  liquidate the trust.

                               If a termination event occurs, the trustee will
                               distribute the underlying securities to you as
                               promptly as practicable after the termination
                               event.

Federal income tax             The federal income tax laws will treat a U.S.
 consequences................  holder of Pharmaceutical HOLDRs as directly
                               owning the underlying securities. The
                               Pharmaceutical HOLDRs themselves will not
                               result in any federal tax consequences separate
                               from the tax consequences associated with
                               ownership of the underlying securities.

Listing......................
                               The Pharmaceutical HOLDRs have been approved
                               for listing on the American Stock Exchange
                               under the symbol "PPH", subject to official
                               notice of issuance. Trading will take place
                               only in round-lots of 100 Pharmaceutical HOLDRs
                               and round-lot multiples. A minimum of 150,000
                               Pharmaceutical HOLDRs will be required to be
                               outstanding when trading begins.

Trading......................  Investors only will be able to acquire, hold,
                               transfer and surrender a round-lot of 100
                               Pharmaceutical HOLDRs. Bid and ask prices,
                               however, will be quoted per single
                               Pharmaceutical HOLDRs.

Clearance and settlement.....
                               The trust will issue Pharmaceutical HOLDRs in
                               book-entry form. Pharmaceutical HOLDRs will be
                               evidenced by one or more global certificates
                               that the trustee will deposit with The
                               Depository Trust Company, referred to as DTC.
                               Transfers within DTC will be in accordance with
                               DTC's usual rules and operating procedures. For
                               further information see "Description of
                               Pharmaceutical HOLDRs."

                                       14
<PAGE>

                                   THE TRUST

      General. This discussion highlights information about the Pharmaceutical
HOLDRs trust. You should read this information, information about the
depositary trust agreement as well as the depositary trust agreement before you
purchase Pharmaceutical HOLDRs. The material terms of the depositary trust
agreement are described in this prospectus under the heading "Description of
the depositary trust agreement."

      The Pharmaceutical HOLDRs trust. The trust will be formed pursuant to the
depositary trust agreement, dated as of January 24, 2000. The Bank of New York
will be the trustee. The Pharmaceutical HOLDRs trust is not a registered
investment company under the Investment Company Act of 1940.

      The Pharmaceutical HOLDRs trust is intended to hold deposited shares for
the benefit of owners of Pharmaceutical HOLDRs. The trustee will perform only
administrative and ministerial acts. The property of the trust will consist of
the underlying securities and all monies or other property, if any, received by
the trustee. The trust will terminate on December 31, 2040 or earlier if a
termination event occurs.

                      DESCRIPTION OF PHARMACEUTICAL HOLDRs

      The trust will issue Pharmaceutical HOLDRs under the depositary trust
agreement described in this prospectus under the heading "Description of the
depositary trust agreement." After the initial offering, the trust may issue
additional Pharmaceutical HOLDRs on a continuous basis when an investor
deposits the requisite underlying securities with the trustee.

      You may only acquire, hold, trade and surrender Pharmaceutical HOLDRs in
a round-lot of 100 Pharmaceutical HOLDRs and round-lot multiples. The trust
will only issue Pharmaceutical HOLDRs upon the deposit of the whole shares of
underlying securities that are represented by a round-lot of 100 Pharmaceutical
HOLDRs. In the event of a stock split, reverse stock split, or other
distribution by the issuer of an underlying security that results in a
fractional share becoming represented by a round-lot of Pharmaceutical HOLDRs,
the trust may require a minimum of more than one round-lot of 100
Pharmaceutical HOLDRs for an issuance so that the trust will always receive
whole share amounts for issuance of Pharmaceutical HOLDRs.

      Pharmaceutical HOLDRs will represent your individual and undivided
beneficial ownership interest in the common stock of the specified underlying
securities. The 20 companies selected as part of this receipt program are
listed above in the section entitled "Highlights of Pharmaceutical HOLDRs--The
Pharmaceutical HOLDRs."

      Beneficial owners of Pharmaceutical HOLDRs will have the same rights and
privileges as they would have if they beneficially owned the underlying
securities outside of the trust. These include the right of investors to
instruct the trustee to vote the common stock, and to receive dividends and
other distributions on the underlying securities, if any are declared and paid
to the trustee by an issuer of an underlying security, as well as the right to
cancel Pharmaceutical HOLDRs to receive the underlying securities. See
"Description of the depositary trust agreement." Pharmaceutical HOLDRs are not
intended to change your beneficial ownership in the underlying securities under
federal securities laws, including Sections 13(d) and 16(a) of the Securities
Exchange Act of 1934.

      The trust will not publish or otherwise calculate the aggregate value of
the underlying securities represented by a receipt. Pharmaceutical HOLDRs may
trade in the secondary market at prices that are lower than the aggregate value
of the corresponding underlying securities. If, in such case, an owner of
Pharmaceutical HOLDRs wishes to realize the dollar value of the underlying
securities, that owner will have to cancel the Pharmaceutical HOLDRs. Such
cancellation will require payment of fees and expenses as described in
"Description of the depositary trust agreement--Withdrawal of underlying
securities."

                                       15
<PAGE>

      Pharmaceutical HOLDRs will be evidenced by one or more global
certificates that the trustee will deposit with DTC and register in the name of
Cede & Co., as nominee for DTC. Pharmaceutical HOLDRs will be available only in
book-entry form. Owners of Pharmaceutical HOLDRs may hold their Pharmaceutical
HOLDRs through DTC, if they are participants in DTC, or indirectly through
entities that are participants in DTC.

                    DESCRIPTION OF THE UNDERLYING SECURITIES

      Selection criteria. The underlying securities are the common stocks of a
group of 20 specified companies involved in various segments of the
pharmaceutical industry and whose common stock is registered under Section 12
of the Exchange Act. The issuers of the underlying securities are among the 20
largest capitalized, most liquid companies in the pharmaceutical industry as
measured by market capitalization and trading volume. The following criteria
were used in selecting the underlying securities on December 15, 1999:

     .  Market capitalization equal to or greater than $950 million;

     .  Average daily trading volume of at least 270,000 shares over the
        60 trading days prior to and including December 15, 1999;

     .  Average daily dollar volume (that is, the average daily trading
        volume multiplied by the closing price on December 15, 1999) of at
        least $7.5 million over the 60 trading days prior to and including
        December 15, 1999; and

     .  A trading history of at least 90 calendar days.

      The market capitalization of a company is determined by multiplying the
price of its common stock by the number of shares of its common stock that are
held by stockholders. In determining whether a company met the above-stated
criteria for inclusion in the Pharmaceutical HOLDRs, Merrill Lynch, Pierce,
Fenner & Smith Incorporated examined available public information about the
company. The ultimate determination of the inclusion of the 20 specified
companies, however, rested solely within the discretion of Merrill Lynch,
Pierce, Fenner & Smith Incorporated.

      After the initial deposit, one or more of the issuers of the underlying
securities may no longer be substantially involved in the Pharmaceutical
industry. In this case, the Pharmaceutical HOLDRs may no longer consist of
securities issued by companies involved in the pharmaceutical industry. Merrill
Lynch, Pierce, Fenner & Smith Incorporated will determine, in its sole
discretion, whether the issuer of a particular underlying security remains in
the pharmaceutical industry and will undertake to make adequate disclosure when
necessary.

      Underlying securities. For a list of the underlying securities
represented by Pharmaceutical HOLDRs, please refer to "Highlights of
Pharmaceutical HOLDRs--The Pharmaceutical HOLDRs." If the underlying securities
change because of a reconstitution event, a revised list of underlying
securities will be set forth in a prospectus supplement and will be available
from the American Stock Exchange and through a widely-used electronic
information dissemination system such as Bloomberg or Reuters.

      No investigation. In selecting the underlying securities, the trust, the
trustee, Merrill Lynch, Pierce, Fenner & Smith Incorporated, and any affiliate
of these entities, have not performed any investigation or review of the
selected companies, including the public filings by the companies, other than
to the extent required to determine whether the companies satisfied the stated
selection criteria. Accordingly, before you acquire Pharmaceutical HOLDRs, you
should consider publicly available financial and other information about the
issuers of the underlying securities. See "Risk factors" and "Where you can
find more information." Investors and market participants should not conclude
that the inclusion of a company in the list is any form of

                                       16
<PAGE>

investment recommendation of that company by the trust, the trustee, Merrill
Lynch, Pierce, Fenner & Smith Incorporated, and any of their affiliates.

      General background and historical information. For a brief description of
the business of each of the issuers of the underlying securities and monthly
pricing information showing the historical performance of each underlying
issuer's securities see "Annex A."

      The following table sets forth the composite performance of all of the
underlying securities represented by a single Pharmaceutical HOLDR, measured at
the close of each business day from June 25, 1998, the first date when all of
the underlying securities were publicly traded, and thereafter as of the end of
each month to December 15, 1999. The following graph sets forth such
performance at the close of each business day during the same period. The
performance table and graph data are adjusted for any splits that may have
occurred over the measurement period. Past movements of the underlying
securities are not necessarily indicative of future values.

<TABLE>
<CAPTION>
                         Pharmaceutical
                             HOLDRs
                         --------------
<S>                      <C>
June 25, 1998...........     83.44
June 1998...............     83.29
July 1998...............     83.53
August 1998.............     75.13
September 1998..........     84.95
October 1998............     87.75
November 1998...........     93.12
December 1998...........     96.47
January 1999............     96.55
February 1999...........     98.39
</TABLE>
<TABLE>
<CAPTION>
                         Pharmaceutical
                             HOLDRs
                         --------------
<S>                      <C>
March 1999..............     100.35
April 1999..............      92.96
May 1999................      89.88
June 1999...............      94.63
July 1999...............      88.14
August 1999.............      91.85
September 1999..........      85.15
October 1999............      97.50
November 1999...........      96.89
December 15, 1999.......      89.87
</TABLE>

            [LINE GRAPH]



                                       17
<PAGE>

                 DESCRIPTION OF THE DEPOSITARY TRUST AGREEMENT

      General. The depositary trust agreement, dated as of January 24, 2000,
among Merrill Lynch, Pierce, Fenner & Smith Incorporated, The Bank of New York,
as trustee, other depositors and the owners of the Pharmaceutical HOLDRs,
provides that Pharmaceutical HOLDRs will represent an owner's undivided
beneficial ownership interest in the common stock of the underlying companies.

      The trustee. The Bank of New York will serve as trustee. The Bank of New
York, which was founded in 1784, was New York's first bank and is the oldest
bank in the country still operating under its original name. The Bank is a
state-chartered New York banking corporation and a member of the Federal
Reserve System. The Bank conducts a national and international wholesale
banking business and a retail banking business in the New York City, New Jersey
and Connecticut areas, and provides a comprehensive range of corporate and
personal trust, securities processing and investment services.

      Issuance, transfer and surrender of Pharmaceutical HOLDRs. You may create
and cancel Pharmaceutical HOLDRs only in round-lots of 100 Pharmaceutical
HOLDRs. You may create Pharmaceutical HOLDRs by delivering to the trustee the
requisite underlying securities. The trust will only issue Pharmaceutical
HOLDRs upon the deposit of the whole shares represented by a round-lot of 100
Pharmaceutical HOLDRs. In the event that a fractional share comes to be
represented by a round-lot of Pharmaceutical HOLDRs, the trust may require a
minimum of more than one round-lot of 100 Pharmaceutical HOLDRs for an issuance
so that the trust will always receive whole share amounts for issuance of
Pharmaceutical HOLDRs. Similarly, you must surrender Pharmaceutical HOLDRs in
integral multiples of 100 Pharmaceutical HOLDRs to withdraw deposited shares
from the trust. The trustee will not deliver fractional shares of underlying
securities, to the extent that any cancellation of Pharmaceutical HOLDRs would
otherwise require the delivery of fractional shares, the trust will deliver
cash in lieu of such shares. You may request withdrawal of your deposited
shares during the trustee's normal business hours. The trustee expects that in
most cases it will deliver your deposited shares within one business day of
your withdrawal request.

      Voting rights. The trustee will deliver you proxy soliciting materials
provided by issuers of the deposited shares so as to permit you to give the
trustee instructions as to how to vote on matters to be considered at any
annual or special meetings held by issuers of the underlying securities.

      Under the depositary trust agreement, the beneficial owners of
Pharmaceutical HOLDRs, other than Merrill Lynch, Pierce, Fenner & Smith
Incorporated owning Pharmaceutical HOLDRs for its own proprietary account as
principal, will have the right to vote to dissolve and liquidate the trust.

      Distributions. You will be entitled to receive, net of trustee fees,
distributions of cash, including dividends, securities or property, if any,
made with respect to the underlying securities. The trustee will use its
reasonable efforts to ensure that it distributes these distributions as
promptly as practicable after the date on which it receives the distribution.
Therefore, you may receive your distributions substantially later than you
would have had you held the underlying securities directly. You will be
obligated to pay any tax or other charge that may become due with respect to
Pharmaceutical HOLDRs. The trustee may deduct the amount of any tax or other
governmental charge from a distribution before making payment to you. In
addition, the trustee will deduct its quarterly custody fee of $2.00 for each
round-lot of 100 Pharmaceutical HOLDRs from quarterly dividends, if any, paid
to the trustee by the issuers of the underlying securities. With respect to the
aggregate custody fee payable in any calendar year for each Pharmaceutical
HOLDR, the trustee will waive that portion of the fee which exceeds the total
cash dividends and other cash distributions received, or to be received, and
payable with respect to such calendar year.

      Record dates. With respect to dividend payments and voting instructions,
the trustee expects to fix the trust's record dates as close as possible to the
record date fixed by the issuer of the underlying securities.

                                       18
<PAGE>

      Shareholder communications. The trustee promptly will forward to you all
shareholder communications that it receives from issuers of the underlying
securities.

      Withdrawal of underlying securities. You may surrender your
Pharmaceutical HOLDRs and receive underlying securities during the trustee's
normal business hours and upon the payment of applicable fees, taxes or
governmental charges, if any. You should receive your underlying securities no
later than the business day after the trustee receives your request. If you
surrender Pharmaceutical HOLDRs in order to receive underlying securities, you
will pay to the trustee a cancellation fee of up to $10.00 per round-lot of 100
Pharmaceutical HOLDRs.

      Further issuances of Pharmaceutical HOLDRs. The depositary trust
agreement provides for further issuances of Pharmaceutical HOLDRs on a
continuous basis without your consent.

      Reconstitution events. The depositary trust agreement provides for the
automatic distribution of underlying securities to you in four circumstances.

     A. If an issuer of underlying securities no longer has a class of
        common stock registered under section 12 of the Securities
        Exchange Act of 1934, then its securities will no longer be an
        underlying security and the trustee will distribute the shares of
        that company to the owners of the Pharmaceutical HOLDRs.

     B. If the SEC finds that an issuer of underlying securities should be
        registered as an investment company under the Investment Company
        Act of 1940, and the trustee has actual knowledge of the SEC
        finding, then the trustee will distribute the shares of that
        company to the owners of the Pharmaceutical HOLDRs.

     C. If the underlying securities of an issuer cease to be outstanding
        as a result of a merger, consolidation or other corporate
        combination, the trustee will distribute the consideration paid by
        and received from the acquiring company to the beneficial owners
        of Pharmaceutical HOLDRs, unless the merger, consolidation or
        other corporate combination is between companies that are already
        included in the Pharmaceutical HOLDRs and the consideration paid
        is additional underlying securities. In this case, the additional
        underlying securities will be deposited into the trust.

     D. If an issuer's underlying securities are delisted from trading on
        a national securities exchange or NASDAQ and are not listed for
        trading on another national securities exchange or through NASDAQ
        within 5 business days from the date such securities are delisted,
        then the trustee will distribute the shares of that company to the
        owners of the Pharmaceutical HOLDRs.

      If a reconstitution event occurs, the trustee will deliver the underlying
security to you as promptly as practicable after the date that the trustee has
knowledge of the occurrence of a reconstitution event.

      Termination of the trust. The trust will terminate if the trustee resigns
and no successor trustee is appointed by Merrill Lynch, Pierce, Fenner & Smith
Incorporated, as initial depositor, within 60 days from the date the trustee
provides notice to Merrill Lynch, Pierce, Fenner & Smith Incorporated, as
initial depositor, of its intent to resign. Upon termination, the beneficial
owners of Pharmaceutical HOLDRs will surrender their Pharmaceutical HOLDRs as
provided in the depositary trust agreement, including payment of any fees of
the trustee or applicable taxes or governmental charges due in connection with
delivery to the owners of the underlying securities. The trust also will
terminate if Pharmaceutical HOLDRs are delisted from the American Stock
Exchange and are not listed for trading on another national securities exchange
or through NASDAQ within 5 business days from the date the Pharmaceutical
HOLDRs are delisted. Finally, the trust will terminate if 75% of the owners of
outstanding Pharmaceutical HOLDRs other than Merrill Lynch, Pierce, Fenner &
Smith Incorporated vote to dissolve and liquidate the trust.

                                       19
<PAGE>

      If a termination event occurs, the trustee will distribute the underlying
securities to you as promptly as practicable after the termination event
occurs.

      Amendment of the depositary trust agreement. The trustee and Merrill
Lynch, Pierce, Fenner & Smith Incorporated, as initial depositor, may amend any
provisions of the depositary trust agreement without the consent of any other
depositor or any of the owners of the Pharmaceutical HOLDRs. Promptly after the
execution of any amendment to the agreement, the trustee must furnish or cause
to be furnished written notification of the substance of the amendment to each
owner of Pharmaceutical HOLDRs. Any amendment that imposes or increases any
fees or charges, subject to exceptions, or that otherwise prejudices any
substantial existing right of the owners of Pharmaceutical HOLDRs will not
become effective until 30 days after notice of the amendment is given to the
owners of Pharmaceutical HOLDRs.

      Issuance and cancellation fees. After the initial public offering, the
trust expects to issue more Pharmaceutical HOLDRs. If you wish to create
Pharmaceutical HOLDRs by delivering to the trust the requisite underlying
securities, the trustee will charge you an issuance fee of up to $10.00 for
each round-lot of 100 Pharmaceutical HOLDRs. If you wish to cancel your
Pharmaceutical HOLDRs and withdraw your underlying securities, the trustee will
charge you a cancellation fee of up to $10.00 for each round-lot of 100
Pharmaceutical HOLDRs issued. The trustee may negotiate either of these fees
depending on the volume, frequency and size of the issuance or cancellation
transactions.

      Commissions. If you choose to create Pharmaceutical HOLDRs after the
conclusion of the initial public offering, you will not be charged the
underwriting fee. However, in addition to the issuance and cancellation fees
described above, you will be responsible for paying any sales commissions
associated with your purchase of the underlying securities that is charged by
your broker, whether it be Merrill Lynch, Pierce, Fenner & Smith Incorporated
or another broker.

      Custody fees. The Bank of New York, as trustee and as custodian, will
charge you a quarterly custody fee of $2.00 for each round-lot of 100
Pharmaceutical HOLDRs to be deducted from any dividend payments or other cash
distributions on underlying securities received by the trustee. With respect to
the aggregate custody fee payable in any calendar year for each Pharmaceutical
HOLDR, the Trustee will waive that portion of the fee which exceeds the total
cash dividends and other cash distributions received, or to be received, and
payable with respect to such calendar year. The trustee cannot recapture unpaid
custody fees from prior years.

      Address of the trustee. The Bank of New York, ADR Department, 101 Barclay
Street, New York, New York 10286.

      Governing law. The depositary trust agreement and Pharmaceutical HOLDRs
will be governed by the laws of the State of New York. The trustee will provide
the depositary trust agreement to any owner of the underlying securities free
of charge upon written request.

      Duties and immunities of the trustee. The trustee will assume no
responsibility or liability for, and makes no representations as to, the
validity or sufficiency, or as to the accuracy of the recitals, if any, set
forth in the Pharmaceutical HOLDRs.

      The trustee undertakes to perform only those duties as are specifically
set forth in the depositary trust agreement. Subject to the preceding sentence,
the trustee will be liable for its own negligence or misconduct except for good
faith errors in judgment so long as the trustee was not negligent in
ascertaining the relevant facts.

                                       20
<PAGE>

                        FEDERAL INCOME TAX CONSEQUENCES

General

      The following is a summary of the U.S. federal income tax consequences
relating to the Pharmaceutical HOLDRs for:

     .  a citizen or resident of the United States;

     .  a corporation or partnership created or organized in the United
        States or under the laws of the United States;

     .  an estate, the income of which is includible in gross income for
        U.S. federal income tax purposes regardless of its source; or

     .  a trust if a court within the United States is able to exercise
        primary supervision over the administration of the trust and one
        or more U.S. persons have the authority to control all substantial
        decisions of the trust (each of the above, a "U.S. receipt
        holder"); and

     .  any person other than a U.S. receipt holder (a "Non-U.S. receipt
        holder").

      This summary is based upon laws, regulations, rulings and decisions
currently in effect, all of which are subject to change, possibly on a
retroactive basis. The discussion does not deal with all U.S. federal income
tax consequences applicable to all categories of investors, some of which may
be subject to special rules. In addition, this summary generally is limited to
investors who will hold the Pharmaceutical HOLDRs as "capital assets"
(generally, property held for investment) within the meaning of Section 1221 of
the Internal Revenue Code of 1986, as amended. We suggest that you consult with
your own tax advisor.

Taxation of the trust

      The trust will provide for flow through tax consequences as it will be
treated as a grantor trust or custodial arrangement for United States federal
income tax purposes.

Taxation of Pharmaceutical HOLDRs

      A receipt holder purchasing and owning Pharmaceutical HOLDRs will be
treated, for U.S. federal income tax purposes, as directly owning a
proportionate share of the underlying securities represented by Pharmaceutical
HOLDRs. Consequently, if there is a taxable cash distribution on an underlying
security, a holder will recognize income with respect to the distribution at
the time the distribution is received by the trustee, not at the time that the
holder receives the cash distribution from the trustee.

      A receipt holder will determine its initial tax basis in each of the
underlying securities by allocating the purchase price for the Pharmaceutical
HOLDRs among the underlying securities based on their relative fair market
values at the time of purchase. Similarly, when a holder sells a receipt, it
will determine the amount realized with respect to each security by allocating
the sales price among the underlying securities based on their relative fair
market values at the time of sale. A holder's gain or loss with respect to each
security will be computed by subtracting its basis in the security from the
amount realized on the security. With respect to purchases of Pharmaceutical
HOLDRs for cash in the secondary market, a receipt holder's aggregate tax basis
in each of the underlying securities will be equal to the purchase price of the
Pharmaceutical HOLDRs. Similarly, with respect to sales of Pharmaceutical
HOLDRs for cash in the secondary market, the amount realized with respect to a
sale of Pharmaceutical HOLDRs will be equal to the aggregate amount realized
with respect to each of the underlying securities.

      The distribution of any securities by the trust upon the surrender of
Pharmaceutical HOLDRs, the occurrence of a reconstitution event, or a
termination event will not be a taxable event. The receipt holders holding
period with respect to the distributed securities will include the period that
the holder held the securities through the trust.

                                       21
<PAGE>

Brokerage fees and custodian fees

      The brokerage fee incurred in purchasing a receipt will be treated as
part of the cost of the underlying securities. Accordingly, a holder includes
this fee in its tax basis in the underlying securities. A holder will allocate
the brokerage fee among the underlying securities using either a fair market
value allocation or pro rata based on the number of shares of each underlying
security. Similarly, the brokerage fee incurred in selling Pharmaceutical
HOLDRs will reduce the amount realized with respect to the underlying
securities.

      A holder will be required to include in its income the full amount of
dividends paid on the underlying securities, even though the depositary trust
agreement provides that the custodian fees will be deducted directly from any
dividends paid. These custodian fees will be treated as an expense incurred in
connection with a holder's investment in the underlying securities and may be
deductible. If a holder is an individual, estate or trust, however, the
deduction of its share of custodian fees will be a miscellaneous itemized
deduction that may be disallowed in whole or in part.

Non-U.S. receipt holders

      Non-U.S. receipt holders should consult their tax advisors regarding U.S.
withholding and other taxes which may apply to an investment in the underlying
securities.

                              ERISA CONSIDERATIONS

      Any plan fiduciary which proposes to have a plan acquire Pharmaceutical
HOLDRs should consult with its counsel with respect to the potential
applicability of ERISA and the Internal Revenue Code to this investment and
whether any exemption would be applicable and determine on its own whether all
conditions have been satisfied. Moreover, each plan fiduciary should determine
whether, under the general fiduciary standards of investment prudence and
diversification, an acquisition of Pharmaceutical HOLDRs is appropriate for the
plan, taking into account the overall investment policy of the plan and the
composition of the plan's investment portfolio.

                              PLAN OF DISTRIBUTION

      In accordance with the depositary trust agreement, the trust will issue
to Merrill Lynch, Pierce, Fenner & Smith Incorporated, and Merrill Lynch,
Pierce, Fenner & Smith Incorporated will deposit the underlying securities to
receive Pharmaceutical HOLDRs. Merrill Lynch & Co., as underwriter, proposes to
offer the Pharmaceutical HOLDRs to the public at the offering price set forth
on the cover page of this prospectus. Merrill Lynch expects the trust to
deliver the initial distribution of Pharmaceutical HOLDRs against deposit of
the underlying securities in New York, New York on February 3, 2000. After the
initial offering, the public offering price, concession and discount may be
changed. The trust will continue to issue Pharmaceutical HOLDRs, in connection
with deposits of underlying securities. This offering is being made in
compliance with Conduct Rule 2810 of the National Association of Securities
Dealers, Inc. Accordingly, Merrill Lynch will not make any sales to a
discretionary account without the prior written approval of a purchaser of
Pharmaceutical HOLDRs.

      Merrill Lynch has from time to time provided investment banking and other
financial services to certain of the issuers of the underlying securities and
expects in the future to provide these services, for which it has received and
will receive customary fees and commissions. It also may have served as
counterparty in other transactions with certain of the issuers of the
underlying securities.

      Merrill Lynch, Pierce, Fenner & Smith Incorporated may use this
prospectus, as updated from time to time, in connection with offers and sales
related to market-making transactions in the Pharmaceutical HOLDRs. Merrill
Lynch, Pierce, Fenner & Smith Incorporated may act as principal or agent in
such transactions. Market-making sales will be made at prices related to
prevailing market prices at the time of sale.

                                       22
<PAGE>

      Merrill Lynch, Pierce, Fenner & Smith Incorporated has agreed to
indemnify the trustee against certain civil liabilities related to acts
performed or not performed by the trustee in accordance with the depositary
trust agreement or periodic reports filed or not filed with the SEC with
respect to the Pharmaceutical HOLDRs. Should a court determine not to enforce
the indemnification provision, Merrill Lynch, Pierce, Fenner & Smith
Incorporated also has agreed to contribute to payments the trustee may be
required to make with respect to such liabilities.

                                 LEGAL MATTERS

      Legal matters, including the validity of the Pharmaceutical HOLDRs will
be passed upon for Merrill Lynch, Pierce, Fenner & Smith Incorporated, the
initial depositor and the underwriter, by Shearman & Sterling, New York, New
York. Shearman & Sterling, as special U.S. tax counsel to the trust, also will
render an opinion regarding the material federal income tax consequences
relating to the Pharmaceutical HOLDRs.

                      WHERE YOU CAN FIND MORE INFORMATION

      Merrill Lynch, Pierce, Fenner & Smith Incorporated has filed a
registration statement on Form S-1 with the SEC covering the Pharmaceutical
HOLDRs. While this prospectus is a part of the registration statement, it does
not contain all the exhibits filed as part of the registration statement. You
should consider reviewing the full text of those exhibits.

      The registration statement is available over the Internet at the SEC's
web site at http://www.sec.gov. You also may read and copy the registration
statement at the SEC's public reference rooms in Washington, D.C., New York,
New York and Chicago, Illinois. Please call the SEC at 1-800-SEC-0330 for more
information on the public reference rooms and their copy charges. Merrill
Lynch, Pierce, Fenner & Smith Incorporated will not and the trust may not be
subject to the requirements of the Exchange Act and accordingly may not file
periodic reports.

      Because the common stock of the issuers of the underlying securities is
registered under the Exchange Act, the issuers of the underlying securities are
required to file periodically financial and other information specified by the
SEC. For more information about the issuers of the underlying securities,
information provided to or filed with the SEC by the issuers of the underlying
securities with respect to their registered securities can be inspected at the
SEC's public reference facilities or accessed through the SEC's web site
referenced above. In addition, information regarding the issuers of the
underlying securities may be obtained from other sources including, but not
limited to, press releases, newspaper articles and other publicly disseminated
information.

      The trust and Merrill Lynch, Pierce, Fenner & Smith Incorporated and its
affiliates are not affiliated with the issuers of the underlying securities,
and the issuers of the underlying securities have no obligations with respect
to Pharmaceutical HOLDRs. This prospectus relates only to Pharmaceutical HOLDRs
and does not relate to the common stock or other securities of the issuers of
the underlying securities. The information in this prospectus regarding the
issuers of the underlying securities has been derived from the publicly
available documents described in the preceding paragraph. We have not
participated in the preparation of these documents or made any due diligence
inquiries with respect to the issuers of the underlying securities in
connection with Pharmaceutical HOLDRs. We make no representation that these
publicly available documents or any other publicly available information
regarding the issuers of the underlying securities are accurate or complete.
Furthermore, we cannot assure you that all events occurring prior to the date
of this prospectus, including events that would affect the accuracy or
completeness of the publicly available documents described in the preceding
paragraph, that would affect the trading price of the common stock of the
issuers of the underlying securities, and therefore the offering and trading
prices of the Pharmaceutical HOLDRs, have been publicly disclosed.

                                       23
<PAGE>

                                    ANNEX A

     This annex forms an integral part of the prospectus.

     The following tables provide a brief description of the business of each
of the issuers of the underlying securities and set forth the split-adjusted
closing market prices, as reported on the applicable primary trading market, of
each of the underlying securities in each month during 1995, 1996, 1997, 1998,
1999 and 2000 through January 2000. All market prices in excess of one dollar
are rounded to the nearest one sixty-fourth of a dollar. An asterisk (*)
denotes that no shares of the issuer were outstanding during that month. The
historical prices of the underlying securities should not be taken as an
indication of future performance.

                              ABBOTT LABORATORIES

     Abbott Laboratories develops, manufactures and sells a broad and
diversified line of health care products and services. Abbott's products
include pharmaceuticals, diagnostic, hospital, nutritional, chemical and
agricultural products. Abbott markets its products worldwide through affiliates
and distributors to retailers, wholesalers and hospitals.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    17 11/16 January   21 1/4   January   27 1/4   January   35 13/32 January   46 7/16  January 32 5/8
February   17 3/4   February  20 7/8   February  28 1/8   February  37 13/32 February  46 5/16
March      17 7/8   March     20 3/8   March     28 1/16  March     37 21/32 March     46 13/16
April      19 11/16 April     20 5/16  April     30 1/2   April     36 9/16  April     48 3/8
May        20       May       21 9/16  May       31 1/2   May       37 3/32  May       45 3/16
June       20 1/4   June      21 3/4   June      33 3/8   June      41       June      45 3/8
July       20       July      21 15/16 July      32 23/32 July      41 5/8   July      42 15/16
August     19 3/8   August    22 1/2   August    29 31/32 August    38 1/2   August    43 3/8
September  21 5/16  September 24 5/8   September 31 31/32 September 43 7/16  September 36 11/16
October    19 7/8   October   25 3/8   October   30 21/32 October   47       October   40 3/8
November   20 5/16  November  27 13/16 November  32 9/16  November  48       November  38
December   20 13/16 December  25 3/8   December  32 3/4   December  49       December  36 5/16
</TABLE>

     The closing price on January 31, 2000 was 32 5/8.

                                 ALLERGAN, INC.

     Allergan, Inc. develops, manufactures and markets a broad range of eye
care specialty pharmaceutical products and ophthalmic surgical products.
Allergan's eye care products treat a variety of diseases and disorders of the
eye and include consumer contact lens products. Its speciality pharmaceutical
products include therapeutic and cosmetic skin care products and products used
for the treatment of neuromuscular disorders. Allergan's surgical products are
primarily used in cataract surgery. Allergan's eye products are marketed and
sold through a global marketing and regional sales force system. Its speciality
pharmaceutical products are sold to drug wholesalers and retail chains.
Allergan effected a 2-for-1 stock split on its common stock in the form of a
stock dividend to shareholders of record on November 18, 1999. The shares of
common stock began trading on a split-adjusted basis on December 9, 1999. The
following table is adjusted to account for this stock split.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    14 1/2   January   16 5/8   January   17 11/16 January   17       January   38 7/16  January   57
February   14 7/16  February  18 5/8   February  17       February  17 1/2   February  40 3/4
March      14 3/4   March     18 7/16  March     14 9/16  March     19       March     43 15/16
April      13 9/16  April     17 11/16 April     13 3/8   April     20 25/32 April     44 15/16
May        13 5/16  May       19 1/4   May       14 13/16 May       21       May       46 1/2
June       13 9/16  June      19 3/4   June      15 29/32 June      23 3/16  June      55 1/2
July       15 1/8   July      20 3/8   July      15 31/32 July      26 1/8   July      47 1/4
August     15 3/16  August    19 7/16  August    16 3/16  August    23 5/8   August    49 15/16
September  16 11/16 September 19 1/16  September 18 3/32  September 29 3/16  September 55
October    14 11/16 October   15 3/16  October   16 15/32 October   31 7/32  October   53 11/16
November   15 1/2   November  16 1/16  November  16 15/16 November  30 7/16  November  49 3/16
December   16 1/4   December  17 13/16 December  16 25/32 December  32 3/8   December  49 3/4
</TABLE>

     The closing price on January 31, 2000 was 57.

                                      A-1
<PAGE>

                       AMERICAN HOME PRODUCTS CORPORATION

      American Home Products Corporation researches, develops, manufactures and
markets a diversified line of products in three primary business segments:
pharmaceuticals, consumer health care and agricultural products. The
pharmaceutical segment manufactures and sells branded and generic ethical
pharmaceuticals, and animal biologicals and pharmaceuticals. The consumer
healthcare segment manufactures and distributes cold and allergy remedies and
nutritional products including Advil, Robitussin, Dimetapp and Centrum Silver
vitamins. The agricultural products segment manufactures and distributes crop
protection and pest control products. American Home Products agreed on November
4, 1999 to merge with Warner-Lambert Company, but this merger agreement is
being presently challenged by Pfizer Inc. Pfizer's challenge is scheduled to be
heard by a Delaware court on February 14, 2000.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    17 17/32 January   25 1/2   January   31 11/16 January   47 23/32 January   58 11/16 January 47 1/16
February   17 7/8   February  24 21/32 February  32       February  46 7/8   February  59 1/2
March      17 13/16 March     27 3/32  March     30       March     47 11/16 March     65 1/4
April      19 5/16  April     26 3/8   April     33 1/16  April     46 9/16  April     61
May        18 7/16  May       26 3/4   May       38       May       48 5/16  May       57 5/8
June       19 11/32 June      30 1/16  June      38 1/4   June      51 3/4   June      57 3/8
July       19 3/4   July      28 3/8   July      41 7/32  July      51 1/2   July      51
August     19 1/4   August    29 5/8   August    36       August    50 1/8   August    41 1/2
September  21 7/32  September 31 7/8   September 36 1/2   September 52 5/8   September 41 1/2
October    22 5/32  October   30 5/8   October   37 1/16  October   48 15/16 October   52 1/4
November   22 13/16 November  32 3/16  November  34 29/32 November  53 3/8   November  52
December   24 1/4   December  29 5/16  December  38 1/4   December  56 3/8   December  39 1/4
</TABLE>

      The closing price on January 31, 2000 was 47 1/16.

                               ANDRX CORPORATION

      Andrx Corporation formulates and commercializes oral controlled-release
pharmaceuticals using proprietary drug delivery technologies. Andrx develops
generic versions of selected high sales volume controlled-release brand name
pharmaceuticals and develops its own brand name formulations of certain
existing drugs available only in immediate-release form. Andrx focuses on
pharmaceutical products with high sales volumes and patents that will expire in
a time frame that allows Andrx to complete development prior to expiration.
Products include a variety of treatments for hypertension, angina, ulcers and
inflammation.

<TABLE>
<CAPTION>
           Closing           Closing           Closing           Closing            Closing          Closing
  1995      Price    1996     Price    1997     Price    1998     Price     1999     Price    2000    Price
- ---------  ------- --------- ------- --------- ------- --------- -------- --------- -------- ------- -------
<S>        <C>     <C>       <C>     <C>       <C>     <C>       <C>      <C>       <C>      <C>     <C>
January       *    January      *    January    9 1/2  January   17 1/8   January   28 5/164 January 70 1/4
February      *    February     *    February   9 3/4  February  15 17/32 February  33 15/16
March         *    March        *    March     12 1/2  March     13 15/16 March     45 9/16
April         *    April        *    April     10 5/8  April     18 3/4   April     39 3/8
May           *    May          *    May       11 7/8  May       16 3/4   May       50 7/164
June          *    June       7 9/16 June      19 1/8  June      18 3/8   June      77 1/8
July          *    July       6 5/8  July      16 5/8  July      17 7/8   July      67 1/16
August        *    August     7 1/4  August    19 5/8  August    14 21/32 August    71 7/8
September     *    September  6 5/8  September 22 3/4  September 18 3/8   September 58 17/32
October       *    October    7 1/8  October   19 1/4  October   19 1/2   October   47 3/4
November      *    November   7      November  19 7/16 November  19 3/4   November  51 1/2
December      *    December   8 1/16 December  17 1/8  December  25 5/8   December  42 5/16
</TABLE>

      The closing price on January 31, 2000 was 70 1/4.

                                      A-2
<PAGE>

                       BIOVAIL CORPORATION INTERNATIONAL

      Biovail Corporation International is a global integrated pharmaceutical
company which specializes in the development of oral controlled-release drugs.
Controlled-release products are formulations which release active drug
compounds in the body gradually and predictably over a 12 to 24 hour period.
Biovail formulates, clinically tests, registers, manufactures and out-licenses
its own drug products. Biovail markets it products through its own sales force
and through licensees. Biovail effected a 2-for-1 stock split on its common
stock to shareholders of record on January 12, 2000. The stock began trading on
a split-adjusted basis on January 20, 2000. The following table is adjusted to
account for this stock split.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January     1 3/8   January   12 15/16 January   14 7/16  January   18       January   21 1/8   January 49 7/8
February    1 3/4   February  14 3/16  February  12 1/16  February  21 25/32 February  19 3/32
March       2 1/8   March     14 3/16  March     11 5/8   March     24 1/8   March     19 1/4
April       2 13/16 April     14 1/8   April     12 1/2   April     20 7/16  April     17 17/32
May         2 5/8   May       17 1/16  May       14 13/16 May       16 31/32 May       19 3/32
June        3 2/16  June      15 5/8   June      15 3/32  June      16       June      25 17/32
July        4       July      13 1/4   July      13 3/8   July      16 7/16  July      28 3/32
August      4 3/16  August    15       August    14 7/32  August    14 1/32  August    28 29/32
September   5 3/4   September 17 3/4   September 14 17/32 September 13 15/32 September 25 3/8
October     6 7/16  October   14 5/8   October   14 7/16  October   15 19/32 October   27 19/32
November    8 3/4   November  14 1/4   November  15 7/16  November  17       November  34 7/8
December   12 7/8   December  12 13/16 December  19 17/32 December  18 29/32 December  46 7/8
</TABLE>

      The closing price on January 31, 2000 was 49 7/8.

                          BRISTOL-MYERS SQUIBB COMPANY

      Bristol-Myers Squibb Company is a diversified health and personal care
company that focuses on the manufacture and sales of a broad range of
pharmaceutical and related products. These products include: cardiovascular,
anti-cancer, anti-infective and central nervous system prescription
pharmaceuticals; consumer medicines, such as analgesics; personal care, such as
skin and hair care products, cold remedies and deodorants; nutritional
products; medical devices; and beauty care products. Bristol-Myers markets its
products internationally to the retail and wholesale markets and some of its
products are sold directly to other pharmaceutical companies, hospitals and
healthcare professionals.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    15 3/8   January   22 1/8   January   31 11/16 January   49 27/32 January   64 1/8   January   66
February   15 15/32 February  21 9/32  February  32 5/8   February  50 3/32  February  62 31/32
March      15 23/32 March     21 13/32 March     29 1/2   March     52 5/32  March     64 1/8
April      16 19/32 April     20 9/16  April     32 3/4   April     52 15/16 April     63 9/16
May        16 9/32  May       21 11/32 May       36 11/16 May       53 3/4   May       68 3/4
June       17 1/32  June      22 1/2   June      40 1/2   June      57 15/32 June      70 7/16
July       17 5/16  July      21 21/32 July      39 5/32  July      56 31/32 July      66 1/2
August     17 3/16  August    21 15/16 August    38       August    48 15/16 August    70 3/8
September  18 7/32  September 2 3/8    September 41 3/8   September 51 15/16 September 67 1/2
October    19 1/16  October   26 7/16  October   43 15/16 October   55 11/32 October   76 13/16
November   20 1/16  November  28 7/16  November  46 13/16 November  61       November  73
December   21 15/32 December  27 1/4   December  47 5/16  December  66 29/32 December  64 3/16
</TABLE>

      The closing price on January 31, 2000 was 66.

                                      A-3
<PAGE>

                              ELI LILLY & COMPANY

      Eli Lilly & Company researches, develops, manufactures and sells
pharmaceutical products for humans and animals. Research efforts are primarily
directed toward discovering and developing products to diagnose and treat
disease in humans and animals and to increase the efficiency of animal food
production. Eli Lilly products include neuroscience products, such as Prozac,
endocrine products, cardiovascular agents, oncology products and animal health
products for cattle, poultry and swine. Eli Lilly's pharmaceutical products are
distributed primarily through independent wholesale distribution outlets and
marketed through its own sales force. The animal health products are marketed
by its own sales force to distributors and feed manufacturers.

<TABLE>
<CAPTION>
           Closing            Closing           Closing            Closing            Closing          Closing
  1995      Price     1996     Price    1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- ------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>     <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    16 15/32 January   28 5/8  January   43 9/16  January   67 5/8   January   93 11/16 January 66 7/8
February   16 3/4   February  30 5/16 February  43 11/16 February  65 13/16 February  94 1/2
March      18 9/324 March     32 1/2  March     41 1/8   March     59 5/8   March     84 7/8
April      18 11/16 April     29 9/16 April     43 15/16 April     69 9/16  April     73 5/8
May        18 21/32 May       32 1/8  May       46 1/2   May       61 3/8   May       71 7/16
June       19 5/8   June      32 1/2  June      54 21/32 June      66 1/4   June      71 5/8
July       19 9/164 July      28      July      56 1/2   July      67 1/4   July      65 11/16
August     20 15/32 August    28 5/8  August    52 5/16  August    65 3/4   August    74 5/8
September  22 15/32 September 32 1/4  September 60 1/2   September 78 5/16  September 64 3/16
October    24 5/32  October   35 1/4  October   67 1/16  October   81       October   68 7/8
November   24 7/8   November  38 1/4  November  63       November  89 11/16 November  72 11/64
December   28 1/8   December  36 1/2  December  69 5/8   December  88 7/8   December  66 1/2
</TABLE>

      The closing price on January 31, 2000 was 66 7/8.

                           FOREST LABORATORIES, INC.

      Forest Laboratories, Inc. develops, manufactures, and sells branded and
generic prescription drugs and nonprescription pharmaceutical products which
are used for the treatment of a wide range of illnesses. Forest's branded
products include treatment for depression, respiratory ailments, hypertension,
angina and urinary tract infection. Forest's generic products include generic
equivalents of its branded products and certain controlled-release products.
Its products are marketed in the United States, Eastern Europe and the United
Kingdom through its own sales force and through independent distributors in
other parts of the world.

<TABLE>
<CAPTION>
           Closing            Closing           Closing            Closing            Closing         Closing
  1995      Price     1996     Price    1997     Price     1998     Price     1999     Price   2000    Price
- ---------  -------- --------- ------- --------- -------- --------- -------- --------- ------- ------- -------
<S>        <C>      <C>       <C>     <C>       <C>      <C>       <C>      <C>       <C>     <C>     <C>
January    24 3/4   January   27      January   18 7/8   January   29 11/16 January   46 3/16 January 67 1/2
February   25 3/8   February  26      February  19 1/16  February  31 9/32  February  49 9/16
March      23 13/16 March     24 3/8  March     18 13/16 March     37 1/2   March     56 3/8
April      22 1/2   April     23 1/16 April     17 1/16  April     36 3/16  April     44 1/2
May        22 1/16  May       20 5/8  May       21 1/8   May       33       May       47 5/8
June       22 3/16  June      19 5/16 June      20 23/32 June      35 3/4   June      46 1/4
July       22 3/16  July      17 1/16 July      22 3/4   July      37 1/2   July      51 1/4
August     22 3/8   August    20 9/16 August    20 23/32 August    32 3/4   August    48 1/2
September  22 1/4   September 18 1/16 September 21 1/16  September 34 3/8   September 42 1/8
October    20 11/16 October   19 1/4  October   23 1/8   October   41 13/16 October   45 7/8
November   21 1/4   November  19 3/8  November  22 3/8   November  46 5/8   November  51 3/16
December   22 5/8   December  16 3/8  December  24 21/32 December  53 3/16  December  61 7/16
</TABLE>

      The closing price on January 31, 2000 was 67 1/2.

                                      A-4
<PAGE>

                           ICN PHARMACEUTICALS, INC.

      ICN Pharmaceuticals, Inc. develops, manufactures, distributes and sells
pharmaceutical, research and diagnostic products as well as biotechnology
research products. ICN's pharmaceutical and nutritional products treat viral
and bacterial infections, diseases of the skin, neuromuscular disorders,
cancer, cardiovascular disease, diabetes and psychiatric disorders.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing         Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price   2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- ------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>     <C>     <C>
January    12 13/64 January   13 1/4   January   15 1/4   January   34 1/4   January   24 1/8  January 25 1/8
February    9 7/16  February  15 21/64 February  16 53/64 February  38 1/2   February  21 7/8
March      10       March     14 53/64 March     14 53/64 March     49       March     25 1/8
April      10 63/64 April     15       April     14 11/64 April     49 1/4   April     33 3/16
May        11 1/16  May       17 43/64 May       14 27/64 May       43 1/16  May       32 7/8
June       10 1/4   June      15 37/64 June      19 1/8   June      45 11/16 June      32 3/16
July       12 49/64 July      14       July      22 3/4   July      28 3/8   July      30 3/4
August     13 21/64 August    14       August    24 11/64 August    15 3/8   August    20 3/4
September  14 13/32 September 13 43/64 September 32 51/64 September 17 1/2   September 17 3/16
October    13 1/2   October   12 37/64 October   32 5/64  October   23 5/16  October   23
November   13 21/64 November  12 59/64 November  32 61/64 November  25 1/4   November  24 5/16
December   12 53/64 December  13 5/64  December  32 43/64 December  22 5/8   December  25 5/16
</TABLE>

      The closing price on January 31, 2000 was 25 1/8.

                                IVAX CORPORATION

      IVAX Corporation researches, develops, manufactures and markets
proprietary and generic pharmaceuticals in the United States and international
markets. IVAX's primary focus is on proprietary oncology and respiratory
pharmaceutical products and generic pharmaceuticals in less competitive market
segments. IVAX markets its proprietary pharmaceutical products through
licensing arrangements and its generic pharmaceutical products are sold to drug
wholesalers and retail drug store chains. On January 14, 2000, IVAX announced a
3-for-2 stock split on its common stock to shareholders of record on February
1, 2000. The shares of common stock will begin trading on a split-adjusted
basis on February 23, 2000. The following table does not take into account any
adjustments for this stock split.

<TABLE>
<CAPTION>
           Closing           Closing           Closing            Closing             Closing          Closing
  1995      Price    1996     Price    1997     Price     1998     Price     1999      Price    2000    Price
- ---------  ------- --------- ------- --------- -------- --------- -------- --------- --------- ------- -------
<S>        <C>     <C>       <C>     <C>       <C>      <C>       <C>      <C>       <C>       <C>     <C>
January    21 1/8  January   26 1/4  January   11 5/8   January    7 1/2   January    13 9/16  January 33 1/4
February   21 5/8  February  28 5/8  February  12 1/4   February   8 7/16  February   14 3/4
March      25      March     25 7/8  March      9 7/8   March      8 3/4   March      11 13/16
April      26      April     29 1/8  April      7 9/16  April      9 3/4   April      13 3/16
May        25 3/4  May       27 1/2  May       10 3/4   May        9 3/16  May        13 7/16
June       24 5/8  June      15 3/4  June      11 3/16  June       9 1/4   June       14 1/8
July       24 1/8  July      14 5/8  July       9 3/8   July       8 15/16 July       15 13/16
August     25 5/8  August    16 1/8  August     9 7/16  August     7 3/4   August     16 1/2
September  30 1/8  September 16 1/4  September 11 15/16 September  8 3/4   September  16 1/2
October    22 3/4  October   16 1/2  October    7 9/16  October    9 1/2   October    17 9/16
November   26 5/8  November  11      November   7 1/16  November   9 1/2   November   20 5/16
December   28 1/2  December  10 1/4  December   6 3/4   December  12 7/16  December   25 3/4
</TABLE>

      The closing price on January 31, 2000 was 33 1/4.

                                      A-5
<PAGE>

                               JOHNSON & JOHNSON

      Johnson & Johnson manufactures and sells health care products and
provides related services in countries around the globe. Johnson & Johnson's
principal consumer segment focuses on personal care and hygienic products and
its product brands include Band-Aid, Tylenol and Stayfree sanitary products.
Johnson & Johnson's pharmaceutical segment focuses on allergy, anti-infective,
anti-fungal, contraceptives and pain management products. Johnson & Johnson's
professional segment, catering to physicians, nurses, therapists and hospitals,
focuses on diagnostic products, surgical instruments, cardiology products and
other medical equipment and devices. Johnson & Johnson markets and distributes
its products directly and through wholesalers. In a $4.9 billion stock-for-
stock exchange, Johnson & Johnson recently merged with Centocor, Inc., a
leading biopharmaceutical company.

<TABLE>
<CAPTION>
           Closing           Closing            Closing            Closing            Closing          Closing
  1995      Price    1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  ------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>     <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    29 1/16 January   48       January   57 3/4   January   66 15/16 January    85 1/8  January 86 1/16
February   28 3/8  February  46 3/4   February  57 1/2   February  75 3/8   February   85 3/8
March      29 3/4  March     46 1/8   March     52 7/8   March     73 7/16  March      93 1/2
April      32 1/2  April     46 1/4   April     61 1/8   April     71 1/2   April      97 1/2
May        33 1/16 May       48 11/16 May       60       May       69 1/16  May        92 5/8
June       33 3/4  June      49 1/2   June      64 3/8   June      74       June       98
July       35 7/8  July      47 3/4   July      62 1/8   July      77 1/4   July       91 1/16
August     34 1/2  August    49 1/4   August    56 11/16 August    69       August    102 1/4
September  37 1/16 September 51 1/4   September 57 11/16 September 78 1/4   September  91 7/8
October    40 3/4  October   49 1/4   October   57 3/8   October   81 1/2   October   104 3/4
November   43 5/16 November  53 1/4   November  62 15/16 November  81 1/4   November  103 3/4
December   42 3/4  December  49 3/4   December  65 7/8   December  83 7/8   December   93 1/4
</TABLE>

      The closing price on January 31, 2000 was 86 1/16.

                               JONES PHARMA INC.

      Jones Pharma Inc. manufactures, markets, distributes and sells specialty
pharmaceutical products under its own trademarks and tradenames. Jones Pharma
seeks to build a portfolio of growing products through the acquisition of
under-promoted or promotion sensitive FDA-approved products from other
pharmaceutical companies. Jones Pharma's principal products serve the endocrine
treatment and critical care segments of the health care industry as well as the
companion animal segment of the veterinary industry. Jones Pharma markets and
promotes its products primarily through a direct sales force.

<TABLE>
<CAPTION>
           Closing           Closing            Closing            Closing             Closing          Closing
  1995      Price    1996     Price     1997     Price     1998     Price     1999      Price    2000    Price
- ---------  ------- --------- -------- --------- -------- --------- -------- --------- --------- ------- -------
<S>        <C>     <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>       <C>     <C>
January    2 9/64  January   11 21/64 January   25 21/64 January   23 19/64 January    21 1/4   January 58 1/16
February   2 33/64 February  13 1/16  February  20 11/64 February  24 3/4   February   18 3/4
March      2 9/16  March     17 7/64  March     16       March     24 1/8   March      23 11/64
April      2 57/64 April     23 7/32  April     23 1/2   April     19 43/64 April      21 27/64
May        2 31/32 May       23 7/16  May       23 59/64 May       20 1/2   May        23 45/64
June       3 19/64 June      22 11/64 June      31 43/64 June      22 5/64  June       26 1/4
July       4 3/16  July      23 5/64  July      19 3/4   July      21 13/64 July       28 15/16
August     4 21/64 August    26 43/64 August    19 53/64 August    13 59/64 August     27 1/16
September  5 19/64 September 32 21/64 September 21       September 19 11/64 September  32 31/32
October    5 25/32 October   29       October   20 5/64  October   21 35/64 October    31
November   6 7/32  November  26 43/64 November  22       November  24       November   34 5/8
December   7 9/64  December  24 27/64 December  25 1/2   December  24 21/64 December   43 7/16
</TABLE>

      The closing price on January 31, 2000 was 58 1/16.

                                      A-6
<PAGE>

                           KING PHARMACEUTICALS, INC.

      King Pharmaceuticals, Inc. manufactures, markets and sells primarily
name-brand prescription pharmaceutical products. King acquires these
pharmaceutical products and seeks to increase their sales by focused promotion
and marketing, as well as by developing product line extensions and through
product life cycle management. King, through a national sales force, markets
its products to general/family practitioners and hospitals across the United
States. King also provides contract manufacturing to pharmaceutical and
biotechnology companies.

<TABLE>
<CAPTION>
           Closing           Closing           Closing           Closing            Closing          Closing
  1995      Price    1996     Price    1997     Price    1998     Price     1999     Price    2000    Price
- ---------  ------- --------- ------- --------- ------- --------- -------- --------- -------- ------- -------
<S>        <C>     <C>       <C>     <C>       <C>     <C>       <C>      <C>       <C>      <C>     <C>
January      *     January      *    January      *    January      *     January   16 5/64  January   59
February     *     February     *    February     *    February     *     February  16 5/64
March        *     March        *    March        *    March        *     March     18 1/2
April        *     April        *    April        *    April        *     April     18 27/64
May          *     May          *    May          *    May          *     May       15 53/64
June         *     June         *    June         *    June       9 21/64 June      17 1/4
July         *     July         *    July         *    July      10 3/4   July      18 5/64
August       *     August       *    August       *    August     9 37/64 August    23 5/64
September    *     September    *    September    *    September  9 11/64 September 23 21/64
October      *     October      *    October      *    October   10 3/8   October   20 11/64
November     *     November     *    November     *    November  10       November  46 1/8
December      *    December     *    December     *    December  17 37/64 December  56 1/16
</TABLE>

      The closing price on January 31, 2000 was 59.

                               MERCK & CO., INC.

      Merck & Co., Inc. develops, manufactures and markets a broad range of
human and animal health products. Merck's operations are divided into a
pharmaceutical and a pharmaceutical benefit services segment. The
pharmaceutical segment creates a variety of therapeutic products including
Zocar (high cholesterol treatment), Pepcid (anti-ulcerant) and Propecia (male
baldness treatment). The pharmaceutical benefit services segment fills and
manages prescriptions and operates health management programs. Merck markets
its health products to drug retailers and wholesalers, hospitals, managed
healthcare providers and government agencies through its own representatives.
Its pharmaceutical benefit management services are marketed to corporations,
insurance companies and government agencies.

<TABLE>
<CAPTION>
           Closing             Closing            Closing            Closing            Closing          Closing
  1995      Price     1996      Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- --------- --------- -------- --------- -------- --------- -------- ------- --------
<S>        <C>      <C>       <C>       <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    20 1/8   January   35 1/16   January   45 5/16  January   58 11/16 January   73 3/8   January 78 13/16
February   21 3/16  February  33 1/8    February  46 1/16  February  63 25/32 February  81 1/2
March      21 5/16  March     31 1/8    March     42 1/8   March     64 3/32  March     80 1/8
April      21 7/16  April     30 1/4    April     45 3/16  April     60 1/4   April     70 3/8
May        23 1/2   May       32 5/16   May       44 15/16 May       58 1/2   May       67 5/8
June       24 9/16  June      32 5/16   June      51 5/32  June      66 7/8   June      73 5/8
July       25 13/16 July      32 1/8    July      51 15/16 July      61 25/32 July      67 5/8
August     24 15/16 August    32 13/16  August    45 29/32 August    57 31/32 August    67 3/16
September  28       September 35 3/16   September 49 31/32 September 64 25/32 September 64 13/16
October    28 3/4   October   36 15/16  October   44 5/8   October   67 17/32 October   79 9/16
November   30 15/16 November  41 1/2    November  47 13/32 November  77 9/16  November  78 11/16
December   32 13/16 December  39 13/164 December  53       December  73 3/4   December  67 3/16
</TABLE>

      The closing price on January 31, 2000 was 78 13/16.

                                      A-7
<PAGE>

                            MYLAN LABORATORIES, INC.

     Mylan Laboratories Inc. develops, licenses, manufactures, markets and
distributes generic and branded pharmaceutical products. Mylan operates through
its generic and branded pharmaceutical segments. Its generic pharmaceutical
segment focuses on marketing a wide variety of lower cost alternatives to
branded products and investing resources in developing new drug delivery
systems. Mylan's branded pharmaceutical segment focuses on the cardiology,
neurology and dermatology areas. Mylan develops its branded pharmaceutical
segment through its own product development and product acquisitions. Mylan
markets its products to retail drug stores, wholesalers, distributors and
public and governmental agencies.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    18 43/64 January   19       January   16 3/8   January   18       January   30 1/2   January 26 5/8
February   20 53/64 February  19 1/2   February  16 3/4   February  20 3/8   February  27 5/16
March      21 11/64 March     21       March     14 3/4   March     23       March     27 7/16
April      20 1/2   April     19 1/2   April     12       April     27 1/8   April     22 11/16
May        19 5/64  May       19       May       15 1/8   May       30       May       25 3/8
June       20 1/2   June      17 3/8   June      14 3/4   June      30 1/4   June      26 1/2
July       20       July      15       July      16 7/8   July      27 3/8   July      22 7/8
August     22 7/8   August    16 3/8   August    21 1/4   August    22 7/8   August    19 13/16
September  20 1/8   September 17 1/8   September 22 7/16  September 29 1/2   September 18 3/8
October    19 1/8   October   15 1/8   October   21 7/8   October   34 7/16  October   17 15/16
November   23 3/8   November  14 3/4   November  22 3/16  November  33 3/16  November  23 9/16
December   23 1/2   December  16 5/8   December  20 15/16 December  31 1/2   December  25 3/16

     The closing price on January 31, 2000 was 26 5/8.

                                  PFIZER INC.

     Pfizer Inc. develops, manufactures and markets medicines for humans and
animals. Pfizer's operations are divided into a pharmaceutical, animal health
and consumer products segments. The pharmaceutical segment includes
prescription drugs for treating cardiovascular and infectious diseases, central
nervous system disorders, diabetes, erectile dysfunction, allergies, arthritis
and other disorders. A leading Pfizer pharmaceutical product is Viagra. The
animal health segment includes antiparasitic, anti-infective and anti-
inflammatory medicines and vaccines for animals. The consumer products segment
focuses on over-the-counter medications and personal care products. Leading
Pfizer consumer products include Zyrtec, Visine and Bengay. Pfizer's
pharmaceutical products are sold principally to wholesalers. Its animal health
products are marketed and sold to animal healthcare professionals and
distributors. Pfizer's consumer products are marketed and sold by its own
representatives to retailers. Pfizer is currently engaged in a hostile takeover
bid for Warner-Lambert Company. Pfizer's challenge is scheduled to be heard by
a Delaware court on February 14, 2000.

<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January     6 13/16 January   11 27/64 January   15 27/64 January   27 1/4   January   42 7/8   January 36 3/8
February    6 59/64 February  10 63/64 February  15 17/64 February  29 1/2   February  43 63/64
March       7 9/64  March     11 13/64 March     14 1/64  March     33 15/64 March     46 1/4
April       7 7/32  April     11 31/64 April     16       April     37 15/16 April     38 23/64
May         7 11/32 May       11 51/64 May       17 11/64 May       34 15/16 May       35 43/64
June        7 43/64 June      11 57/64 June      19 59/64 June      36 15/64 June      36 21/64
July        8 7/16  July      11 41/64 July      19 7/8   July      36 39/64 July      33 7/8
August      8 15/64 August    11 53/64 August    18 31/64 August    31       August    37 3/4
September   8 57/64 September 13 3/16  September 20 3/64  September 35 1/4   September 35 7/8
October     9 9/16  October   13 51/64 October   23 43/64 October   35 49/64 October   39 11/16
November    9 43/64 November  14 15/16 November  24 1/4   November  37 5/16  November  36 5/8
December   10 1/2   December  13 53/64 December  24 55/64 December  41 43/64 December  32 7/16
</TABLE>

     The closing price on January 31, 2000 was 36 3/8.

                                      A-8
<PAGE>

                            PHARMACIA & UPJOHN, INC.

      Pharmacia & Upjohn, Inc. develops, manufactures and sells pharmaceutical
and healthcare products. Pharmacia provides prescription and nonprescription
products for humans and pharmaceutical chemicals and other products for
livestock and companion animals. Its principal prescription and non-
prescription pharmaceutical products focus on the treatment of a broad range of
conditions including growth hormone deficiency, erectile dysfunction,
depression, male baldness, smoking addiction and diarrhea. Pharmacia products
include Nicorette, Rogaine and Kaopectate. Pharmacia markets its products
through its own representatives and through local distributors and licensees.
On December 19, 1999, Pharmacia announced that it had entered into a definitive
agreement to merge with Monsanto Company.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    23 3/16  January   41 5/8   January   37 1/4   January   38 9/16  January   57 1/2   January   47
February   24 5/16  February  41 7/8   February  37       February  39 27/32 February  54 1/2
March      24 9/16  March     39 7/8   March     36 5/8   March     43 3/4   March     62 3/8
April      25       April     38 1/4   April     29 7/8   April     42 1/16  April     55 5/8
May        25 3/32  May       40 7/8   May       34 5/8   May       44 3/16  May       55 7/16
June       25 61/64 June      44 3/8   June      34 3/4   June      46 1/8   June      56 13/16
July       26 35/64 July      41 1/8   July      37 3/4   July      47 5/16  July      53 13/16
August     29 7/32  August    42       August    34 1/16  August    41 11/16 August    52 1/4
September  30 25/32 September 41 1/4   September 36 1/2   September 50 3/16  September 49 5/8
October    35       October   36       October   31 3/4   October   52 7/8   October   53 15/16
November   35 7/8   November  38 5/8   November  33 3/4   November  52 1/8   November  54 11/16
December   38 3/4   December  39 5/8   December  36 5/8   December  56 5/8   December  45

      The closing price on January 31, 2000 was 47.

                          SCHERING-PLOUGH CORPORATION

      Schering-Plough Corporation researches, develops and markets new
therapies and treatment programs. Schering-Plough's core product groups include
allergy, respiratory, anti-infective, anticancer, dermatologicals, and
cardiovascular pharmaceutical products, and healthcare products, including foot
care and sun care products. Schering-Plough also develops and markets animal
health biological and pharmaceutical products. Schering-Plough's products
include Claritin (allergy), Coppertone (sun care) and Dr. Scholl's (footcare).

<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- -------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January     9 13/16 January   13 9/16  January   18 29/32 January   36 3/16  January   54 1/2   January   44
February    9 51/64 February  14 1/32  February  19 3/32  February  38 1/32  February  55 11/16
March       9 19/64 March     14 17/32 March     18 3/16  March     40 7/8   March     55 1/4
April       9 27/64 April     14 11/32 April     19 15/16 April     40 5/32  April     48 5/16
May         9 27/32 May       14 21/32 May       22 11/16 May       41 13/16 May       45 1/16
June       11 1/32  June      15 11/16 June      23 15/16 June      45 13/16 June      52 1/2
July       11 5/8   July      13 3/4   July      27 9/32  July      48 3/8   July      49
August     11 21/32 August    13 31/32 August    24       August    43       August    52 5/8
September  12 27/32 September 15 11/32 September 25 3/4   September 51 27/32 September 43 5/8
October    13 13/32 October   16       October   28 1/32  October   51 7/16  October   49 1/2
November   14 11/32 November  17 13/16 November  31 11/32 November  53 3/8   November  51 1/8
December   13 11/16 December  16 3/16  December  31 1/16  December  55 1/4   December  42 3/8
</TABLE>

      The closing price on January 31, 2000 was 44.

                                      A-9
<PAGE>

                             WARNER-LAMBERT COMPANY

     Warner-Lambert Company researches, develops, manufactures and markets a
widely diversified line of health care and consumer products. Warner-Lambert's
principal business segments are: pharmaceutical products, consumer health care
products and confectionery products. Warner-Lambert's pharmaceutical products
include a variety of analgesic, anti-infective and cardiovascular
pharmaceuticals and are marketed primarily under the Parke-Davis and Goedecke
trade name directly to healthcare professionals. Warner-Lambert's consumer
healthcare products include a wide variety of products including dermatological
products, such as Lubriderm, and cold and allergy treatments, such as Benadryl
and Sudafed. Warner-Lambert's confectionary products primarily include chewing
gum, such as Trident, breath mints and cough drops. Both the consumer
healthcare and confectionary products are marketed directly to wholesalers and
retailers. Warner-Lambert agreed on November 4, 1999 to merge with American
Home Products Corporation, but that merger agreement is being contested by
Pfizer Inc., which is seeking to acquire Warner-Lambert in a hostile take-over
bid. Pfizer's challenge is scheduled to be heard by a Delaware court on
February 14, 2000.

<TABLE>
<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- --------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    13       January   15 5/8   January   27       January   50 11/64 January   72 3/8   January 94 15/16
February   12 3/4   February  16 31/64 February  28       February  48 51/64 February  68 13/16
March      13 3/64  March     17 13/64 March     28 53/64 March     56 49/64 March     66 1/4
April      13 5/16  April     18 41/64 April     32 43/64 April     63 1/8   April     67 13/16
May        13 51/64 May       18 43/64 May       33 43/64 May       63 13/16 May       62
June       14 25/64 June      18 21/64 June      41 27/64 June      69 3/8   June      69 1/8
July       13 63/64 July      18 11/64 July      46 39/64 July      75 3/8   July      66
August     15 1/16  August    19 53/64 August    42 23/64 August    65 1/4   August    66 3/8
September  15 7/8   September 22       September 44 63/64 September 75 1/2   September 66 3/8
October    14 3/16  October   21 13/64 October   47 51/64 October   78 3/8   October   79 13/16
November   14 7/8   November  23 53/64 November  46 5/8   November  75 1/2   November  90
December   16 3/16  December  25       December  41 25/64 December  75 3/16  December  81 15/16

     The closing price on January 31, 2000 was 94 15/16.

                          WATSON PHARMACEUTICALS, INC.

     Watson Pharmaceuticals, Inc. develops, produces, markets, and distributes
branded and generic pharmaceutical products. Watson's products include
prescription and over-the-counter therapeutic and preventive agents used for
the treatment of human diseases and disorders in the primary care, women's
health, dermatology and neurology/psychiatry areas. Watson markets its branded
pharmaceutical products through specialty sales groups who focus on healthcare
professionals. Watson's generic pharmaceutical products are sold to drug
wholesalers, distributors and retailers, hospitals and health maintenance
organizations.

<CAPTION>
           Closing            Closing            Closing            Closing            Closing          Closing
  1995      Price     1996     Price     1997     Price     1998     Price     1999     Price    2000    Price
- ---------  -------- --------- -------- --------- -------- --------- -------- --------- -------- ------- --------
<S>        <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>       <C>      <C>     <C>
January    12 3/8   January   22 7/8   January   22 13/32 January   36 3/4   January   54 5/8   January 40 5/16
February   12 29/32 February  21 1/2   February  21 13/16 February  35 7/8   February  48 3/8
March      14 3/4   March     20       March     17 7/8   March     36       March     44 1/8
April      15 9/16  April     23 3/4   April     17 7/8   April     43 1/16  April     40 1/2
May        18 3/8   May       22 1/2   May       19 9/16  May       43 3/4   May       38 5/16
June       19 1/2   June      18 15/16 June      21 1/8   June      46 11/16 June      35 1/16
July       18       July      19 1/2   July      24 3/4   July      45 1/8   July      34 7/16
August     20 11/16 August    14 1/2   August    26 9/32  August    45 1/16  August    35 7/8
September  20 1/2   September 18 3/4   September 29 7/8   September 51 3/4   September 30 9/16
October    22 3/8   October   16 11/16 October   31 3/4   October   55 13/16 October   31 3/4
November   23 9/16  November  19 1/2   November  29 3/4   November  53 7/8   November  37 3/16
December   24 1/2   December  22 15/32 December  32 7/16  December  62 7/8   December  35 13/16
</TABLE>

     The closing price on January 31, 2000 was 40 5/16.

                                      A-10
<PAGE>

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[LOGO OF PHARMACEUTICAL HOLDRs SM]

                       1,000,000,000 Depositary Receipts
                         Pharmaceutical HOLDRs SM Trust

                              -------------------

                              P R O S P E C T U S

                              -------------------

                              Merrill Lynch & Co.

                                January 31, 2000

      Until February 25, 2000 (25 days after the date of this prospectus), all
dealers effecting transactions in the offered Pharmaceutical HOLDRs, whether or
not participating in this distribution, may be required to deliver a
prospectus. This requirement is in addition to the obligations of dealers to
deliver a prospectus when acting as underwriters and with respect to unsold
allotments or subscriptions.

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