<PAGE> 1
SCHEDULE 14A INFORMATION
PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES
EXCHANGE ACT OF 1934
Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]
Check the appropriate box:
<TABLE>
<S> <C>
[ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission
Only (as permitted by Rule 14a-6(e)(2))
[X] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to sec.240.14a-11(c) or sec.240.14a-12
</TABLE>
OSI Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
(Name of Registrant as Specified In Its Charter)
- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
Payment of Filing Fee (Check the appropriate box):
[X] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
(1) Title of each class of securities to which transaction applies:
------------------------------------------------------------------------
(2) Aggregate number of securities to which transaction applies:
------------------------------------------------------------------------
(3) Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
filing fee is calculated and state how it was determined):
------------------------------------------------------------------------
(4) Proposed maximum aggregate value of transaction:
------------------------------------------------------------------------
(5) Total fee paid:
------------------------------------------------------------------------
[ ] Fee paid previously with preliminary materials.
[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number,
or the Form or Schedule and the date of its filing.
(1) Amount Previously Paid:
------------------------------------------------------------------------
(2) Form, Schedule or Registration Statement No.:
------------------------------------------------------------------------
(3) Filing Party:
------------------------------------------------------------------------
(4) Date Filed:
------------------------------------------------------------------------
<PAGE> 2
[OSI LETTERHEAD]
February 3, 1998
Dear Stockholders:
It is a pleasure to invite you to the annual meeting of stockholders of OSI
Pharmaceuticals, Inc., formerly known as Oncogene Science, Inc. (the
"Corporation"), which will be held at the Corporation's headquarters, located at
106 Charles Lindbergh Boulevard, Uniondale, New York, on Wednesday, March 25,
1998, at 10:00 a.m. Eastern Standard Time. Information about the matters to be
voted upon at the meeting is in the attached Notice of Annual Meeting of
Stockholders and Proxy Statement.
In addition to the matters to be voted upon at the meeting there will be a
presentation made on recent developments relating to the Corporation. Specific
directions to the Corporation's headquarters may be obtained by calling or
writing to Ms. Kathy Galante, Investor Relations Coordinator, OSI
Pharmaceuticals, Inc., 106 Charles Lindbergh Boulevard, Uniondale, New York
11553, telephone no. (516) 222-0023.
In order to assure that a quorum is present at the meeting, you are urged
to sign and mail the enclosed proxy card at once, even though you may plan to
attend in person. You may revoke the proxy granted in the proxy card at any time
prior to its being voted by filing with the Secretary of the Corporation either
an instrument of revocation or a duly executed proxy card bearing a later date.
If you attend the meeting, you may elect to revoke the proxy and vote your
shares in person.
The Corporation's Annual Report to Stockholders for the fiscal year ended
September 30, 1997, is being distributed to stockholders with the attached Proxy
Statement.
Sincerely,
GARY E. FRASHIER
Chairman and Chief Executive Officer
<PAGE> 3
OSI PHARMACEUTICALS, INC.
106 CHARLES LINDBERGH BOULEVARD
UNIONDALE, NEW YORK 11553
------------------------
NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
------------------------
The annual meeting of stockholders of OSI Pharmaceuticals, Inc., formerly
known as Oncogene Science, Inc. (the "Corporation"), will be held at the
Corporation's headquarters, located at 106 Charles Lindbergh Boulevard,
Uniondale, New York, on Wednesday, March 25, 1998, at 10:00 a.m., for the
following purposes:
(1) to elect eight directors;
(2) to ratify the appointment of KPMG Peat Marwick LLP as the independent
public accountants to audit the Corporation's accounts for the fiscal
year ending September 30, 1998; and
(3) to transact such other business as may properly come before the meeting
or any adjournment or adjournments thereof.
The Board of Directors has fixed the close of business on January 26, 1998,
as the record date for determining stockholders entitled to notice of and to
vote at the meeting. A complete list of stockholders entitled to vote at the
meeting will be open to examination by stockholders for any purpose germane to
the meeting during normal business hours at the Corporation's offices at 106
Charles Lindbergh Boulevard, Uniondale, New York 11553.
By Order of the Board of Directors,
ROBERT L. VAN NOSTRAND
Secretary
February 3, 1998
IMPORTANT
Whether or not you plan to attend the meeting, please sign and date the
enclosed proxy and return it in the postage-paid envelope enclosed for your
convenience. Returning a proxy will not deprive you of your right to attend the
annual meeting and vote your shares in person.
<PAGE> 4
OSI PHARMACEUTICALS, INC.
106 CHARLES LINDBERGH BOULEVARD
UNIONDALE, NEW YORK 11553
------------------------
PROXY STATEMENT
This Proxy Statement is furnished to the stockholders of OSI
Pharmaceuticals, Inc., a Delaware corporation (the "Corporation"), in connection
with the solicitation of proxies by the Board of Directors for use at the annual
meeting of stockholders of the Corporation to be held on March 25, 1998, and any
adjournment or adjournments thereof (the "Meeting"). A copy of the Notice of
Annual Meeting of Stockholders accompanies this Proxy Statement. It is
anticipated that the mailing of this Proxy Statement will commence on or about
January 30, 1998.
Only holders of record of the Corporation's common stock (the "Common
Stock") at the close of business on January 26, 1998, the record date for the
Meeting, will be entitled to notice of and to vote at the Meeting. On the record
date, the Corporation had issued and outstanding 21,369,283 shares of Common
Stock, which are the only securities of the Corporation entitled to vote at the
Meeting. Each share is entitled to one vote.
The presence at the Meeting, in person or by proxy, of the holders of a
majority of the issued and outstanding shares of Common Stock entitled to vote
at the Meeting will be necessary to constitute a quorum. If a broker that is a
record holder of Common Stock does not return a signed proxy, the shares of
Common Stock represented by such proxy will not be considered present at the
Meeting and will not be counted toward establishing a quorum. If a broker that
is a record holder of Common Stock does return a signed proxy, but is not
authorized to vote on one or more matters (each such matter, a "broker
non-vote"), the shares of Common Stock represented by such proxy will be
considered present at the Meeting for purposes of determining the presence of a
quorum.
Assuming a quorum is present, (i) directors of the Corporation will be
elected by a plurality of the votes cast by stockholders present, in person or
by proxy, and entitled to vote for the election of directors at the Meeting, and
(ii) the affirmative vote of a majority of the votes cast by stockholders
present, in person or by proxy, and entitled to vote at the Meeting will be
required for the ratification of the appointment of the auditors for the current
fiscal year. Abstentions and broker non-votes will have no effect on the outcome
of the election of directors or the ratification of the appointment of the
auditors.
Stockholders who execute proxies may revoke them by giving written notice
to the Secretary of the Corporation at any time before such proxies are voted.
Attendance at the Meeting will not have the effect of revoking a proxy unless
the stockholder attending the Meeting shall, in writing, notify the Secretary of
the Corporation of the revocation of the proxy at any time prior to the voting
of the proxy.
The Board of Directors does not know of any matter other than the election
of directors, and the ratification of the appointment of the auditors for the
current fiscal year that is expected to be presented for consideration at the
Meeting. However, if other matters properly come before the Meeting, the persons
named in the accompanying proxy intend to vote thereon in accordance with their
judgment. All proxies received pursuant to this solicitation will be voted,
except as to matters where authority to vote is specifically withheld, and where
a choice is specified as to the proposal, in accordance with such specification.
If no instructions are given, the persons named in the proxy solicited by the
Board of Directors intend to vote (i) FOR the nominees for election as directors
of the Corporation named below under the caption "Election of Directors," and
(ii) FOR the ratification of the appointment of KPMG Peat Marwick LLP as the
independent public accountants to audit the Corporation's accounts for the
fiscal year ending September 30, 1998.
The Corporation will bear the cost of the Meeting and the cost of
soliciting proxies, including the cost of mailing the proxy materials. In
addition to solicitation by mail, directors, officers and regular employees of
the Corporation (who will not be specifically compensated for such services) may
solicit proxies by telephone. The Corporation may engage Corporate Investor
Communications, Inc. ("CIC") to assist in the solicitation of proxies from
stockholders. In the event the Corporation does engage CIC, the Corporation will
enter into an agreement with CIC pursuant to which the Corporation will pay CIC
a fee of approximately $7,000 plus reimbursement of reasonable out-of-pocket
expenses.
<PAGE> 5
VOTING SECURITIES AND PRINCIPAL STOCKHOLDERS
The following table sets forth certain information as of December 31, 1997,
regarding the beneficial ownership of Common Stock by (i) all persons known to
the Corporation who own more than 5% of the outstanding shares of Common Stock,
(ii) all corporate stockholders with whom the Corporation has entered into
strategic collaborations, (iii) each director and nominee for director, (iv)
each executive officer, and (v) all officers and directors as a group. Unless
otherwise indicated, the persons named in the table below have sole voting and
investment power with respect to all shares of Common Stock shown as
beneficially owned by them.
<TABLE>
<CAPTION>
PERCENT OF
NAME AND ADDRESS NO. OF SHARES CLASS(1)
- --------------------------------------------------------------- ------------- ----------
<S> <C> <C>
Amerindo Investment Advisors Inc............................... 3,446,600 16.1%
388 Market Street
San Francisco, California 94111
Hoechst Marion Roussel, Inc.................................... 1,590,909(2) 7.2%
10236 Marion Park Drive
Kansas City, Missouri 64137
Novartis Pharma AG............................................. 909,091 4.2%
CH-4002 Basel
Switzerland
Pfizer Inc..................................................... 587,500 2.7%
235 East 42nd Street
New York, New York 10017
BioChem Pharma (International) Inc............................. 500,000 2.3%
275 Armand-Frappier Boulevard
Laval, Quebec
Canada H7V 4A7
G. Morgan Browne............................................... 106,332(3) *
Arthur M. Bruskin, Ph.D........................................ 81,624(4) *
Walter P. Carney, Ph.D......................................... 58,528(5) *
Gary E. Frashier............................................... 211,832(6) *
John H. French, II............................................. 69,932(7) *
Edwin A. Gee, Ph.D............................................. 208,672(8) *
Colin Goddard, Ph.D............................................ 119,034(9) *
Daryl K. Granner, M.D.......................................... 56,186(10) *
Walter M. Lovenberg, Ph.D...................................... 66,339(11) *
Steve M. Peltzman.............................................. 216,358(12) *
Ann H. Rose, Ph.D.............................................. 82,591(13) *
Gary Takata.................................................... 15,260(14) *
Robert L. Van Nostrand......................................... 70,932(15) *
John P. White.................................................. 51,682(16) *
All directors and executive officers as a group (fourteen
persons)..................................................... 1,415,302(17) 6.2%
</TABLE>
- ---------------
* Represents ownership that does not exceed 1% of the outstanding shares of
the Corporation's Common Stock.
(1) Beneficial ownership is determined in accordance with the rules of the
Securities and Exchange Commission and generally includes voting or
investment power with respect to securities. Shares of Common Stock subject
to stock options and warrants currently exercisable, or exercisable within
60 days are deemed beneficially owned by the person holding such options
and warrants. The percent of the outstanding shares of the Corporation's
Common Stock for any person or group who as of December 31, 1997,
beneficially owned any shares pursuant to options which are exercisable
within 60 days of December 31, 1997, is calculated assuming all such
options have been exercised in full and adding the number of shares subject
to such options to the total number of shares issued and outstanding on
December 31, 1997 for each individual.
2
<PAGE> 6
(2) Includes 500,000 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding warrants.
(3) Includes 400 shares owned by Mr. Browne's wife, as to which Mr. Browne
disclaims beneficial ownership. Also includes 69,182 shares that may be
acquired at or within 60 days of December 31, 1997, pursuant to the
exercise of outstanding options. Also includes 21,750 shares owned by Cold
Spring Harbor Laboratory, of which Mr. Browne is an executive officer. Mr.
Browne disclaims beneficial ownership of the shares owned by Cold Spring
Harbor Laboratory.
(4) Includes 81,011 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(5) Includes 58,210 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(6) Includes 202,173 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(7) Includes 50,432 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(8) Consists entirely of shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(9) Includes 117,456 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of options.
(10) Consists entirely of shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(11) Includes 63,339 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(12) Includes 198,679 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(13) Includes 82,486 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(14) Includes 9,700 shares owned by Mr. Takata's wife, as to which Mr. Takata
disclaims beneficial ownership. Also includes 5,560 shares that may be
acquired at or within 60 days of December 31, 1997 pursuant to the exercise
of outstanding options.
(15) Includes 69,815 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(16) Includes 31,682 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
(17) Includes 1,294,883 shares that may be acquired at or within 60 days of
December 31, 1997 pursuant to the exercise of outstanding options.
3
<PAGE> 7
ELECTION OF DIRECTORS
At the Meeting, eight directors are to be elected, each to hold office
(subject to the Corporation's Bylaws) until the next annual meeting of
stockholders and until his respective successor has been elected and qualified.
The nominees for election to the Board of Directors are named in the table
below. If any nominee listed in the table below should become unavailable for
any reason, which management does not anticipate, the proxy will be voted for
any substitute nominee selected by management prior to or at the Meeting, or for
a motion to reduce the membership of the Board to the number of nominees
available. One present director will not stand for reelection as of the date of
the Meeting. The Board has determined not to fill the vacancy at this time, and
the proxies solicited hereby will not be voted for more than eight nominees. The
information concerning the nominees has been furnished by them to the
Corporation.
<TABLE>
<CAPTION>
NAME AGE POSITION(S) WITH THE CORPORATION
- ----------------------------------- --- ----------------------------------------------------
<S> <C> <C>
Gary E. Frashier................... 61 Chairman of the Board, Chief Executive Officer and
Director
Edwin A. Gee, Ph.D................. 77 Chairman, Emeritus of the Board and Director
G. Morgan Browne................... 62 Director
John H. French, II................. 66 Director
Daryl K. Granner, M.D.............. 61 Director
Walter M. Lovenberg, Ph.D.......... 63 Director
Steve M. Peltzman.................. 51 Director
John P. White...................... 51 Director
</TABLE>
BIOGRAPHICAL INFORMATION
Gary E. Frashier has been Chairman of the Board since December 1997 and
Chief Executive Officer of the Corporation since March 1994. From March 1994 to
December 1997, Mr. Frashier was Vice Chairman of the Board. Mr. Frashier had
been President and Chief Executive Officer of the Corporation from March 1990 to
March 1994. From April 1987 to February 1990, he served as President, Chief
Executive Officer and a director of Genex Corporation, a biotechnology company
which specializes in protein engineering. From 1984 to March 1987, he was
Chairman, President and Chief Executive Officer of Continental Water Systems
Corporation, a corporation engaged in the manufacture and marketing of equipment
to produce ultrapure water, which was purchased from Millipore Corporation
("Millipore") in a management buy-out organized by Mr. Frashier. Mr. Frashier
served as an Executive Vice President of Millipore and President of Waters
Associates, Inc., Millipore's liquid chromatography subsidiary, from 1980 to
1983. He presently serves as a director of NuGene Technologies, Inc. and Anaderm
Research Corp. Mr. Frashier also serves as a director of Helicon Therapeutics,
Inc. Mr. Frashier was elected to the Board of Directors of the Corporation in
March 1990.
Edwin A. Gee, Ph.D., a director of the Corporation since 1985, served as
President, Chairman of the Board and Chief Executive Officer of International
Paper Company from 1978 until his retirement in April 1985. Prior to 1978, Dr.
Gee was a Senior Vice President, member of the Executive Committee and a
director of E.I. du Pont de Nemours and Company. Dr. Gee serves as a member of
the Board of Directors of Biocryst Pharmaceuticals, Inc. and the Buckhill Falls
Company. Dr. Gee is also Director Emeritus of the Salomon Brothers Fund, Inc.,
the Salomon Brothers Investors Fund, Inc. and the Salomon Brothers Capital Fund,
Inc. Dr. Gee served as an executive officer of the Corporation, holding the
position of Chairman of the Board of the Corporation from April 1987 until March
1990. From March 1990 to December 1997, Dr. Gee was Chairman of the Board, but
no longer served as an officer of the Corporation. As of December 1997, Dr. Gee
was elected Chairman, Emeritus of the Board of the Corporation.
G. Morgan Browne has been Administrative Director of Cold Spring Harbor
Laboratory since June 1985. Prior to 1985, Mr. Browne provided management
services to a series of scientifically based companies. He is presently a
director of Harris & Harris Group, Inc. and the New York Biotechnology
Association, as well as Treasurer and a director of the Long Island Research
Institute. Mr. Browne became a director of the Corporation in March 1993.
4
<PAGE> 8
John H. French, II, has been Vice Chairman of Southern Pacific Petroleum
N.L. (U.S.) for the past six years and Vice Chairman of CyberAction Limited
(Bermuda). Mr. French was a director of the Russian American Chamber of Commerce
from December 1994 to December 1996, and prior to that time he was Chairman of
this organization from July 1992. He was Chairman of the Board from January 1990
to February 1992, and President from 1960 to February 1992, of Research and
Science Investors, Inc., a New York venture capital concern. Mr. French became a
director of the Corporation in July 1988.
Daryl K. Granner, M.D., has been a professor and Chairman of Molecular
Physiology/Biophysics and of Internal Medicine at Vanderbilt University since
July 1984. From 1970 to 1984 he was a faculty member at the University of Iowa,
where he directed the Division of Endocrinology and Diabetes. He directs the
Vanderbilt Diabetes Center and is an acknowledged authority in the mechanism of
insulin action and the pathophysiology of diabetes mellitus. He has served on
numerous national advisory panels. Dr. Granner has been a director of the
Corporation since September 1996. Prior to that, Dr. Granner was an independent
consultant providing consulting services to the Corporation since 1992.
Walter M. Lovenberg, Ph.D., was an Executive Vice President and member of
the Board of Directors of Marion Merrell Dow Inc. from 1989 through August 1993.
Dr. Lovenberg served as President of the Merrell Dow Research Institute from
1989 to 1993 and Vice President from 1986 through 1989. Dr. Lovenberg has
received the Fulbright-Hayes Senior Scholar Award, the Public Health Service
Superior Service Award and the Third International Award for Research on Adult
Diseases. Dr. Lovenberg currently serves as a member of the Board of Directors
of Xenometrix, Inc., Cytoclonal Pharmaceutics, Inc., and Inflazyme, Inc. He has
served on the Scientific Advisory Board of Amilyn Pharmaceuticals since 1996.
Dr. Lovenberg has served as a director and the Chief Executive Officer of
Helicon Therapeutics, Inc. since July 1997. Dr. Lovenberg has served as a
consultant to the Corporation since October 1993. Dr. Lovenberg became a
director of the Corporation in March 1994.
Steve M. Peltzman served as President of the Corporation from March 1994 to
July 1997. From March 1994 to September 1996, Mr. Peltzman was President and
Chief Operating Officer of the Corporation. Prior to that, he had been the
Corporation's Executive Vice President and Chief Operating Officer since October
1991, upon consummation of the acquisition by the Corporation of the cancer
business of Applied bioTechnology, Inc. From June 1984 until October 1991, he
served as President and Chief Executive Officer of Applied bioTechnology, Inc.
From 1986 to 1990, Mr. Peltzman was also President of a partnership between
Applied bioTechnology, Inc. and E.I. du Pont de Nemours and Company, which
focused on the development of products relating to the prevention, diagnosis and
treatment of human cancer. Mr. Peltzman presently serves as President and Chief
Executive Officer as well as a director of NuGene Technologies, Inc. He also
presently serves as a director of IBI-Imaging bioPharmaceutical, Inc. and
LifeScience Economics, Inc. Mr. Peltzman became a director of the Corporation in
March 1992.
John P. White is a partner of Cooper & Dunham LLP, a New York City law firm
specializing in patent, trademark and related intellectual property matters, and
has been associated with the firm since 1977. Mr. White is a member of numerous
professional organizations, both legal and scientific, and has written and
lectured extensively on the subject of legal protection for biotechnology. Mr.
White has been a director of the Corporation since May 1985.
GENERAL INFORMATION
The Corporation's directors are elected at the annual meeting of
stockholders and hold office (subject to the Bylaws of the Corporation) until
the next succeeding annual meeting of stockholders and until their successors
are elected and qualified. Each of the nominees named above, was elected as a
director of the Corporation at the annual meeting of stockholders held on March
19, 1997.
The Board of Directors held four meetings during the last fiscal year. None
of the directors attended fewer than 75% of the number of meetings of the Board
of Directors or any committee of which he is a member held during the period in
which he was a director or a committee member, as applicable.
5
<PAGE> 9
The Board of Directors has an Executive Committee, which currently consists
of Dr. Gee and Messrs. Frashier, French and White. The Executive Committee held
one meeting during the last fiscal year. The principal function of the Executive
Committee is to exercise all the power and authority of the Board of Directors
between meetings of the Board of Directors.
The Board of Directors has a Nominating Committee, which currently consists
of Dr. Gee and Messrs. Frashier, French and White. The Nominating Committee held
one meeting during the last fiscal year. The principal functions of the
Nominating Committee are to review and select candidates for nomination to the
Board of Directors. In fulfilling this responsibility, the Nominating Committee
considers recommendations received from stockholders and other qualified
sources. Stockholders may submit recommendations with regard to nominees for
election to the Board of Directors by letter addressed to the Secretary of the
Corporation.
The Compensation Committee of the Board of Directors currently consists of
Drs. Gee and Lovenberg and Messrs. French and White. The Compensation Committee
held two meetings during the last fiscal year. The Compensation Committee is
authorized subject to the Certificate of Incorporation and Bylaws of the
Corporation and the Delaware General Corporation Law, to exercise all power and
authority of the Board of Directors with respect to the compensation of
employees of the Corporation. It also addresses a variety of organizational
matters with respect to the Corporation and its employees. The Compensation
Committee also administers the Corporation's stock option plans.
The Audit Committee of the Board of Directors currently consists of Drs.
Gee and Granner and Mr. Browne. The Audit Committee held one meeting during the
last fiscal year. The Audit Committee is responsible for reviewing the adequacy
of the structure of the Corporation's financial organization and the
implementation of its financial and accounting policies. In addition, the Audit
Committee reviews the results of the audit performed by the Corporation's
outside auditors before the Annual Report to Stockholders is published.
THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE ELECTION OF EACH OF THE
NOMINEES FOR ELECTION TO THE BOARD OF DIRECTORS NAMED ABOVE.
6
<PAGE> 10
EXECUTIVE OFFICERS OF THE CORPORATION
The names and ages of the executive officers of the Corporation as of
December 31, 1997, and their positions with the Corporation are as follows:
<TABLE>
<CAPTION>
NAME AGE POSITION(S) WITH THE CORPORATION
- ------------------------------ --- --------------------------------------------------------
<S> <C> <C>
Gary E. Frashier.............. 61 Chairman and Chief Executive Officer since December
1997; Vice Chairman and Chief Executive Officer from
March 1994 to December 1997; President and Chief
Executive Officer from March 1990 to March 1994
Colin Goddard, Ph.D........... 38 President since August 1997; Executive Vice President
and Chief Operating Officer since September 1996; Vice
President, Research Operations since April 1995; Vice
President, Research Operations, Pharmaceutical Division
since December 1993; Director, Pharmaceutical Operations
since February 1993; Director, Drug Discovery since May
1992; Program Manager, Drug Discovery since April 1991;
Staff scientist since 1989
Robert L. Van Nostrand........ 40 Vice President and Chief Financial Officer since
December 1996; Vice President, Finance and
Administration since May 1990; Treasurer since March
1992; Secretary since March 1995; Controller and Chief
Accounting Officer from September 1986 to May 1990
Arthur M. Bruskin, Ph.D. ..... 42 Senior Vice President, Drug Discovery since October
1996; Vice President, Drug Discovery since April 1995;
Director, Drug Discovery since July 1994; Director,
Cancer Research since April 1992; Director, Molecular
Genetics since October 1991
Walter P. Carney, Ph.D. ...... 47 Vice President, Diagnostics since June 1997; Vice
President and General Manager, Diagnostics and
Proprietary Drug Development Program since June 1995;
Vice President, Pre-clinical Proprietary Program since
1994; Director of Research and Development since 1991
Ann H. Rose, Ph.D............. 56 Vice President, TGF-Beta Program and Regulatory Affairs
since April 1994
</TABLE>
Set forth below is a biographical description of each executive officer's
employment prior to employment by the Corporation, based on information supplied
by such executive officers:
Gary E. Frashier. See "Election of Directors."
Colin Goddard, Ph.D., was employed as a research scientist with the
National Cancer Institute in Bethesda, Maryland prior to his employment by the
Corporation.
Robert L. Van Nostrand was employed by the accounting firm of Touche Ross &
Co. prior to his employment by the Corporation. Mr. Van Nostrand is a certified
public accountant.
Arthur M. Bruskin, Ph.D., was employed as Manager of Cancer Research at
Applied bioTechnology, Inc. in Cambridge, Massachusetts prior to his employment
by the Corporation. Dr. Bruskin has served as Vice President of Anaderm Research
Corp. since October 1996 and Vice President of Helicon Therapeutics, Inc. since
July 1997.
Walter P. Carney, Ph.D., was employed as Manager-Transgenic Animals and
Cancer Scouting Group at E.I. du Pont de Nemours and Company prior to his
employment by the Corporation. Dr. Carney has served as President of Oncogene
Science Diagnostics, Inc., a wholly-owned subsidiary of the Corporation, since
October 1997.
Ann H. Rose, Ph.D., was an independent consultant providing clinical and
regulatory development consulting services to companies in the biopharmaceutical
area prior to her employment by the Corporation.
7
<PAGE> 11
EXECUTIVE COMPENSATION
SUMMARY OF COMPENSATION
The following table sets forth a summary of all compensation paid or
accrued by the Corporation for services rendered for the last three completed
fiscal years to its chief executive officer and its five other most highly
compensated executive officers (the "named executive officers"):
SUMMARY COMPENSATION TABLE
<TABLE>
<CAPTION>
LONG TERM
ANNUAL COMPENSATION COMPENSATION
---------------------------------- ------------
OTHER SECURITIES
NAME AND FISCAL ANNUAL UNDERLYING ALL OTHER
PRINCIPAL POSITION YEAR SALARY BONUS(a) COMPENSATION OPTIONS(#) COMPENSATION(b)
- ----------------------------- ------ -------- -------- ------------ ------------ ---------------
<S> <C> <C> <C> <C> <C> <C>
Gary E. Frashier............. 1997 $280,000 $110,000 -- 100,000 $ 4,750
Chairman, Chief Executive 1996 274,969 100,000 -- 100,000 4,750
Officer, Director 1995 265,884 90,000 -- -- 4,621
Colin Goddard, Ph.D.......... 1997 $168,154 $ 60,000 -- 50,000 $ 5,045
President 1996 129,646 50,000 -- 90,000 3,889
1995 119,914 35,000 -- 35,000 3,598
Robert L. Van Nostrand....... 1997 $133,144 $ 45,000 -- 55,000 $ 4,098
Vice President, Chief 1996 116,548 35,000 -- 35,000 3,496
Financial Officer 1995 109,750 28,500 -- 15,000 3,571
Arthur M. Bruskin, Ph.D...... 1997 $151,158 $ 50,000 -- 40,000 $ 4,535
Senior Vice President, 1996 115,596 40,000 -- 75,000 3,375
Drug Discovery 1995 106,423 27,500 -- 25,000 3,193
Walter P. Carney, Ph.D (c)... 1997 $126,577 $ 40,000 -- 35,000 $ 2,846
Vice President, Diagnostics 1996 120,471 30,000 -- 25,000 2,902
1995 114,865 23,000 $ 8,873(d) 30,000 3,259
Ann H. Rose, Ph.D............ 1997 $151,865 $ 20,000 $ 20,000(e) 20,000 $ 2,843
Vice President, TGF-Beta 1996 149,015 25,000 20,000(e) 25,000 2,850
Program & Regulatory 1995 141,346 25,000 20,000(e) 25,000 3,747
Affairs
Steve M. Peltzman(f)......... 1997 $186,118 -- -- -- $ 4,192
Director 1996 203,809 $ 50,000 -- 50,000 4,875
1995 192,289 50,000 -- 112,500 4,987
</TABLE>
- ---------------
(a) Bonuses are paid subsequent to the end of the fiscal year.
(b) Represents the Corporation's contributions to the executive officers'
"401(K) Savings Plan."
(c) Dr. Carney was promoted to an executive officer position effective June
1997.
(d) A Special Achievement Award.
(e) In 1997, 1996 and 1995, Dr. Rose's other compensation included $20,000 in
reimbursement for office expenses.
(f) Mr. Peltzman served as President of the Corporation from March 1994 to July
1997.
8
<PAGE> 12
STOCK OPTION GRANTS
The following table sets forth grants of stock options made during the
Corporation's fiscal year ended September 30, 1997, to each of the named
executive officers:
OPTION GRANTS IN LAST FISCAL YEAR
<TABLE>
<CAPTION>
POTENTIAL REALIZED
VALUE AT ASSUMED
ANNUAL
INDIVIDUAL GRANTS RATES OF STOCK
---------------------------------------------------- PRICE APPRECIATION
% OF TOTAL FOR
OPTIONS GRANTED OPTION TERM
OPTIONS TO EMPLOYEES EXERCISE EXPIRATION ---------------------
NAME GRANTED(a) IN FISCAL YEAR PRICE DATE 5% 10%
- ------------------------------ ---------- --------------- -------- ---------- -------- ----------
<S> <C> <C> <C> <C> <C> <C>
Gary E. Frashier.............. 100,000 11.02% $6.875 6/12/07 $433,125 $1,093,125
Colin Goddard, Ph.D........... 50,000 5.51% 6.875 6/12/07 216,563 546,563
Robert L. Van Nostrand........ 25,000 2.75% 7.094 12/11/06 111,731 281,987
30,000 3.31% 6.875 6/12/07 129,938 327,938
Arthur M. Bruskin, Ph.D....... 40,000 4.41% 6.875 6/12/07 173,250 437,250
Walter P. Carney, Ph.D........ 35,000 3.86% 6.875 6/12/07 151,594 382,594
Ann H. Rose, Ph.D............. 20,000 2.20% 6.875 6/12/07 86,625 218,625
Steve M. Peltzman............. -- -- -- -- -- --
</TABLE>
- ---------------
(a) All options vest one-third one year from the date of grant and the remainder
pro rata monthly over the ensuing 24 months.
EXERCISE OF OPTIONS
The following table sets forth (i) certain information relating to options
exercised by the named executive officers during the fiscal year ended September
30, 1997, and (ii) the total number of unexercised options at September 30,
1997, and the total value of unexercised in-the-money options at September 30,
1997, for the named executive officers:
AGGREGATED OPTION EXERCISES IN LAST
FISCAL YEAR AND FISCAL YEAR END OPTION VALUES
<TABLE>
<CAPTION>
AGGREGATED OPTION NUMBER OF SECURITIES
EXERCISES DURING UNDERLYING
FISCAL 1997 UNEXERCISED OPTIONS VALUE OF UNEXERCISED
------------------------ AT FISCAL YEAR IN-THE-MONEY OPTIONS
SHARES END(#) AT FISCAL YEAR END(a)
ACQUIRED VALUE -------------------- -----------------------
NAME ON EXERCISE REALIZED VESTED UNVESTED VESTED UNVESTED
- -------------------------- ----------- -------- ------- -------- ---------- --------
<S> <C> <C> <C> <C> <C> <C>
Gary E. Frashier.......... -- -- 177,006 172,994 $1,107,191 $624,059
Colin Goddard, Ph.D. ..... -- -- 95,676 122,324 469,697 453,928
Robert L. Van Nostrand.... -- -- 51,328 78,672 274,687 279,814
Arthur M. Bruskin,
Ph.D. .................. -- -- 63,443 97,496 287,133 353,651
Walter P. Carney,
Ph.D. .................. -- -- 49,392 57,758 271,475 226,119
Ann H. Rose, Ph.D. ....... -- -- 72,421 42,579 434,295 165,080
Steve M. Peltzman......... -- -- 171,688 60,812 1,085,135 282,053
</TABLE>
- ---------------
(a) Based on the closing sale price of the Corporation's Common Stock of $10.875
per share, as reported on the Nasdaq National Market on September 30, 1997,
less the exercise price.
9
<PAGE> 13
COMPENSATION OF DIRECTORS
Monetary Compensation
Drs. Gee, Granner and Lovenberg and Messrs. Browne, French, Peltzman,
Takata and White (being the non-employee directors of the Corporation) are the
only current directors compensated for attendance at Board of Directors'
meetings. Mr. Peltzman's compensation began in July 1997. Each director is paid
a $1,500 retainer per month and $1,500 for each meeting of the Board of
Directors he attends. In addition, each of these persons receives $250 for each
meeting of a committee of the Board he attends that is held on the same day as a
meeting of the Board of Directors, and $500 for each meeting of a committee of
the Board he attends that is held on a date other than a date upon which a
meeting of the Board of Directors is held.
Formula Option Grants
Pursuant to the Corporation's 1993 Incentive and Non-Qualified Stock Option
Plan, as amended (the "1993 Plan"), any director who is not also an employee of
the Corporation or the designee of a third party who is entitled to
representation on the Board of Directors (a "Non-Employee Director") is entitled
to an automatic, formula based grant of non-qualified stock options ("NSOs").
The 1997 Incentive and Non-Qualified Stock Option Plan (the "1997 Plan")
continues the automatic, formula-based grants of NSOs to Non-Employee Directors
established pursuant to the Corporation's 1993 Plan. Each Non-Employee Director
receives an NSO to purchase 50,000 shares of Common Stock upon the Non-Employee
Director's initial election to the Board at a meeting of stockholders (the
"Initial Options"). Each Initial Option vests one-half immediately upon grant,
and one-half upon the Non-Employee Director's reelection to the Board for a
second consecutive term.
In addition to the Initial Options, the 1997 Plan provides for the annual
grant of NSOs (the "Annual Options") to Non-Employee Directors at such times and
in such amounts as set forth in the table below, provided that no Annual Options
may be issued following the termination of the 1997 Plan, which is March 18,
2007. Each Annual Option vests one-third upon the first anniversary of its date
of grant (the "Grant Date"), with the remainder vesting ratably on a monthly
basis over the succeeding 24 months:
SCHEDULE OF ANNUAL OPTION AWARDS
<TABLE>
<CAPTION>
NUMBER OF SHARES
UNDERLYING
ANNUAL OPTION
AWARDS TIMING OF AWARDS
- ---------------- -----------------------------------------------------------------------------
<C> <S>
20,000 On the date of the Non-Employee Director's reelection to a third one-year
term;
20,000 On the date of the Non-Employee Director's reelection to a fourth one-year
term;
15,000 On the later of the date of the annual meeting of stockholders in 1998 or the
date of the Non-Employee Director's reelection to a sixth one-year term;
10,000 On the later of the date of the annual meeting of stockholders in 1999 or the
date of the Non-Employee Director's reelection to a seventh one-year term;
10,000 On the later of the date of the annual meeting of stockholders in 2000 or the
date of the Non-Employee Director's reelection to an eighth one-year term;
and
10,000 On the later of the date of the annual meeting of stockholders in 2001 or the
date of the Non-Employee Director's reelection to a ninth one-year term.
</TABLE>
The exercise price of both the Initial Options and Annual Options
(collectively, the "Formula Options") is equal to 100% of the fair market value
of the Common Stock on the Grant Date. The Formula Options expire on the tenth
anniversary of their respective Grant Dates, subject to the sooner expiration
upon the occurrence of certain events set forth in the 1997 Plan which are
generally applicable to all options granted under the 1997 Plan. Benefits
attributable to future grants of Annual Options are not determinable since such
benefits depend, in part, upon the price of the Corporation's Common Stock on
the date of grant.
10
<PAGE> 14
On March 19, 1997, each of Dr. Gee and Messrs. Browne, French, Takata and
White received a formula award of options covering 15,000 shares, and Drs.
Granner and Lovenberg received a formula award of options covering 50,000 shares
and 20,000, respectively.
Stock Purchase Plan
Pursuant to the Corporation's Directors' Stock Purchase Plan (the "DSPP"),
adopted as of March 25, 1996, all Non-Employee Directors may elect to receive up
to 50% of their monthly retainer fees and up to 50% of attendance fees earned
during any month in the form of shares of Common Stock. The Corporation reserved
100,000 shares of Common Stock for issuance under the DSPP.
Other Payments
Dr. Gee was paid $50,000 by the Corporation in the last fiscal year for
services rendered as a general business consultant. Dr. Lovenberg was paid
$50,000 by the Corporation in the last fiscal year for services rendered as a
general business consultant. Dr. Granner was paid $43,900 by the Corporation in
the last fiscal year for services rendered as a general business consultant.
EMPLOYMENT AGREEMENTS
Gary E. Frashier
In February 1990, the Corporation entered into a three-year employment
agreement with Gary E. Frashier, Chairman and Chief Executive Officer of the
Corporation. The initial term of the agreement expired in February 1993, but
pursuant to its terms, the agreement has been extended automatically on a
year-to-year basis. Under the agreement, Mr. Frashier is entitled to a minimum
base salary plus such other amounts, if any, as the Board may from time to time
determine. In addition, Mr. Frashier is eligible for incentive bonus
compensation in an amount up to 50% of his base salary. The agreement provides
that Mr. Frashier will be entitled to other customary fringe benefits generally
available to executive employees of the Corporation. The agreement prohibits Mr.
Frashier from competing with or becoming engaged in the same business as the
Corporation during the term of employment plus two years thereafter. The
agreement provides Mr. Frashier with severance benefits in the event the
Corporation terminates his employment, other than for cause or due to Mr.
Frashier's death or disability, or reduces his title, job duties, salary or
benefits following a change in control. Upon termination of the agreement by the
Corporation, the Corporation will be obligated to continue Mr. Frashier's
benefits and salary for the six month period immediately following such
termination, unless such termination is for cause or due to death or disability.
In the event Mr. Frashier terminates his employment due to a change in control
of the Corporation, Mr. Frashier will receive a payment equal to 2.99 times his
base salary, and all options that were previously granted to him shall become
exercisable.
Other Executive Officers
The Corporation has entered into employment agreements with Colin Goddard,
Ph.D., and Ann H. Rose, Ph.D. (collectively, the "Officers"). Each agreement has
a fixed term of five and three years, respectively, but provides for automatic
extensions for additional one-year terms. The agreements provide for a minimum
base salary, plus such other amounts, if any, as the Board may from time to time
determine. In addition, the Officers are eligible for incentive bonus
compensation and are entitled to receive other customary fringe benefits
generally available to executive employees of the Corporation. The agreements
prohibit the Officers from competing with or becoming engaged in the same
business as the Corporation during the term of employment plus one or two years
thereafter. The agreements also provide the Officers with severance benefits in
the event the Corporation terminates employment other than for cause or due to
the Officers' death or disability. Upon such termination of an agreement by the
Corporation, the Corporation will be obligated to pay the affected Officer's
benefits and salary for the six month period immediately following such
termination.
11
<PAGE> 15
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
During the Corporation's fiscal year ended September 30, 1997, the
Compensation Committee consisted of Drs. Gee and Lovenberg and Messrs. French
and White. Dr. Gee served as an executive officer of the Corporation from 1987
through 1990.
During the Corporation's fiscal year ended September 30, 1997, Mr.
Frashier, Chief Executive Officer of the Corporation, served as a director and
member of the Compensation Committee of Helicon Therapeutics, Inc. ("Helicon")
while Dr. Lovenberg, Chief Executive Officer of Helicon, served as a director
and member of the Compensation Committee of the Corporation. Please refer to
"Certain Relationships and Related Transactions" for a description regarding the
Corporation's relationship with Helicon.
12
<PAGE> 16
REPORT OF THE COMPENSATION COMMITTEE
TO: THE BOARD OF DIRECTORS
It is a part of the responsibility of the Corporation's Compensation
Committee (the "Committee") to exercise the power and authority of the Board of
Directors with respect to the compensation of employees and to administer the
Corporation's stock option plans. Consequently it is the Committee's
responsibility to review compensation levels of members of management and to
evaluate the performance of management.
In evaluating the reasonableness of compensation paid to the Corporation's
executive officers, the Committee takes into account how compensation compares
to compensation paid by competing companies as well as the Corporation's
performance. In making this determination, the Committee has relied in part on
independent surveys of compensation of management of companies in the
biotechnology and pharmaceutical areas.
It is the Corporation's policy that the compensation of executive officers
be based, in substantial part, on the Corporation's performance, as well as the
individual contribution of each executive officer. As a result, much of an
executive officer's compensation is "at risk" in the form of bonus and stock
option compensation with target levels established by the Committee for each
position relative to total cash compensation.
The base salary of Gary Frashier, the Corporation's Chief Executive
Officer, for fiscal 1997 was based principally on his rights under an employment
agreement with the Corporation dated February 1990 (the "Employment Agreement").
The Employment Agreement established a minimum base annual salary based on
negotiations between the Board of Directors and Mr. Frashier in connection with
his joining the Corporation in February 1990. This amount has been increased
each year by the Compensation Committee to keep pace with salaries being paid to
other chief executive officers of similar companies and in recognition of the
Corporation's performance. Mr. Frashier's base annual salary generally becomes
effective on April 1st of each year, for the ensuing twelve-month period.
Under the Employment Agreement, Mr. Frashier is eligible for incentive
bonus compensation in an amount up to 50% of his base salary. Because the
Corporation is in the development stage, the use of traditional performance
standards (such as profit levels and return on equity) are not appropriate in
the evaluation of Mr. Frashier's performance. For fiscal year 1997, the
Committee awarded Mr. Frashier a bonus of $110,000 in recognition of achievement
of the following objectives: the initiation of Phase I clinical trials for
cancer under the collaborative program with Pfizer Inc. ("Pfizer"); the
initiation of Phase II clinical trials for wound healing under the collaborative
program with Novartis Pharma AG; the establishment of a collaboration with
Hoechst Marion Roussel, Inc. ("HMRI") for discovering and developing drugs to
induce EPO; the establishment of a collaboration with Sankyo Company, Ltd. in
influenza; the extension of the base HMRI research collaboration until the year
2002; the identification of active lead compounds and the commencement of the
funded research phase of the Anaderm Research Corp. joint venture with Pfizer;
the establishment of Helicon Therapeutics, Inc. with Hoffman-La Roche, Inc. and
Cold Spring Harbor Laboratory for the development of central nervous system
drugs with the Corporation owning a 28% equity stake and royalties; the
acquisition of an exclusive worldwide license to a library of approximately
140,000 small molecule compounds for the discovery of pharmaceuticals and
cosmeceuticals from the Dow Chemical Company; the addition of chemistry and
pre-clinical capabilities and the integration of last year's acquisitions of
MYCOsearch, Inc. and Aston Molecules Ltd.; the expansion of the co-venture with
BioChem Pharma (International) Inc. in anti-virals to include Hepatitis B; and
the issuance of a key patent covering the Corporation's reporter-based gene
transcription technology.
The Corporation's performance for purposes of compensation decisions is
measured under the Corporation's Annual Business Plan against goals established
prior to the start of the fiscal year by the Committee and is reviewed and
approved by the Committee. The Committee weights individual performance so that
in each case the discretionary annual bonuses fall within a preset range.
13
<PAGE> 17
During 1997, the Committee also considered the grant of stock options to
each of the Corporation's executive officers. Each of those officers was
considered for stock options based on his or her responsibilities and relative
position in the Corporation and his or her existing stock option position.
Edwin A. Gee, Ph.D., Chairman
John H. French, II
Walter M. Lovenberg, Ph.D.
John P. White
STOCK PRICE PERFORMANCE GRAPH
The following graph presents a five-year comparison of cumulative returns
on the Corporation's Common Stock against the Standard & Poor's 500 Stock Index
("S&P 500 Index") and the Dow Jones Industry Group Biotechnology ("Peer Group
Index"), based on an assumed investment of $100 on October 1, 1992, in each case
assuming reinvestment of all dividends.
COMPARE 5-YEAR CUMULATIVE TOTAL RETURN
AMONG OSI PHARMACEUTICALS, INC.,
S&P 500 INDEX AND PEER GROUP INDEX
<TABLE>
<CAPTION>
MEASUREMENT PERIOD OSI
(FISCAL YEAR COVERED) PHARMACEUTICALS PEER GROUP INDEX S&P 500 INDEX
<S> <C> <C> <C>
1992 100.00 100.00 100.00
1993 91.43 99.75 113.01
1994 74.29 102.17 117.18
1995 122.86 144.65 152.04
1996 202.86 181.33 182.96
1997 248.57 194.77 256.97
</TABLE>
14
<PAGE> 18
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
Mr. John P. White, a director of the Corporation, is a partner of Cooper &
Dunham LLP, a New York law firm specializing in patent, trademark and related
intellectual property matters. Cooper & Dunham LLP regularly provides legal
services to the Corporation. Professional fees paid or accrued by the
Corporation to Cooper & Dunham LLP in the fiscal year ended September 30, 1997
did not exceed 5% of such law firm's gross revenues for its last full fiscal
year.
Mr. Steve M. Peltzman, a director of the Corporation, is President and
Chief Executive Officer and serves as a director of NuGene Technologies, Inc.
("NuGene"), a privately held biotechnology company developing products based on
its cell targeting and drug delivery technologies. During the fiscal year ended
September 30, 1997, the Corporation invested $100,000 in NuGene.
Dr. Walter M. Lovenberg, a director of the Corporation, is the Chief
Executive Officer and a director of Helicon Therapeutics, Inc. ("Helicon"). Mr.
G. Morgan Browne, a director of the Corporation, is the Administrative Director
of Cold Spring Harbor Laboratory ("CSHL"). In July 1997, the Corporation, CSHL
and Hoffman-La Roche Inc.("Roche") formed Helicon. In exchange for approximately
28% of Helicon's outstanding capital stock, the Corporation agreed to perform
for Helicon $1 million of molecular screening services within one year and
granted to Helicon a nonexclusive license with respect to certain screening
technology. CSHL contributed a royalty-free license to commercialize certain
technology relating to genes associated with long-term memory in exchange for a
portion of Helicon's outstanding capital stock. Roche contributed cash for a
portion of Helicon's outstanding capital stock. Certain individuals associated
with CSHL hold the remaining outstanding capital stock of Helicon. The parties
have entered into various collaborative research and license agreements pursuant
to which they will jointly pursue the discovery, development and
commercialization of novel drugs for the treatment of long-term memory disorders
and other central nervous system dysfunctions. The Corporation's net investment
in Helicon at September 30, 1997 was $124,000.
The Corporation and HMRI are parties to two collaborative agreements.
Effective as of January 1, 1997, the Corporation entered into a Collaborative
Research and License Agreement with HMRI to develop orally active, small
molecule inducers of erythropoietin gene expression for the treatment of anemia
due to chronic renal failure and anemia associated with chemotherapy for AIDS
and cancer. Under the terms of the agreement, both the Corporation and HMRI are
contributing medicinal chemistry and pre-clinical optimization teams. HMRI has
the sole responsibility to conduct pre-clinical and clinical development of drug
candidates emerging from the program. The Corporation may receive from HMRI up
to $30 million in research funding, milestone payments and success fees
depending on HMRI's clinical success. During fiscal 1997, the Corporation
received and recorded as income a $1,000,000 initiation fee from HMRI in
connection with this program, 50% of which will be credited against future
royalties, if any. Under the agreement, HMRI has been granted exclusive
worldwide licenses by the Corporation with respect to products resulting from
the joint program. In consideration for such licenses, HMRI will pay royalties
to the Corporation on sales of such products. In addition, effective as of April
1, 1997, the Corporation and HMRI entered into an Amended Collaborative Research
and License Agreement that consolidated and extended formerly separate
collaborative programs between the Corporation and each of Marion Merrell Dow
Inc. ("MMDI"), Hoechst Roussel Pharmaceuticals, Inc. ("Hoechst Roussel") and
Hoechst AG ("Hoechst"). This resulted from the corporate reorganization of HMRI
in July 1995 in which the pharmaceutical operations of MMDI, Hoechst Roussel and
Hoechst were combined into HMRI. This agreement provides for HMRI and the
Corporation to collaborate in the discovery and development of drugs for the
treatment of atherosclerosis, inflammation, arthritis and metabolic diseases.
Under this agreement, HMRI has been granted certain exclusive, worldwide
licenses by the Corporation, and has the right to negotiate with the Corporation
within specified parameters to obtain certain other exclusive, worldwide
licenses with respect to products resulting from joint research programs. In
consideration for their licenses, HMRI will pay royalties to the Corporation on
sales of such products. In fiscal year 1997, the Corporation earned an aggregate
of $5,800,000 in research funding under the agreement. HMRI holds 1,090,909
shares of Common Stock of the Corporation, and a warrant to purchase an
additional 500,000 shares.
15
<PAGE> 19
RATIFICATION OF APPOINTMENT OF AUDITORS
The firm of KPMG Peat Marwick LLP, independent certified public
accountants, has audited the books and records of the Corporation for several
years and the Board of Directors desires to continue the services of this firm
for the current fiscal year. Accordingly, the Board recommends that the
stockholders vote FOR the ratification of the appointment by the Board of
Directors of the firm of KPMG Peat Marwick LLP to audit the books and accounts
of the Corporation for the current fiscal year.
Representatives of KPMG Peat Marwick LLP are expected to be available at
the Meeting to respond to appropriate questions and will be given the
opportunity to make a statement if they desire to do so. If the stockholders do
not ratify the appointment of this firm, the appointment of another firm of
independent certified public accountants will be considered by the Board of
Directors.
THE BOARD OF DIRECTORS DEEMS THE RATIFICATION OF THE APPOINTMENT OF KPMG
PEAT MARWICK LLP AS THE AUDITORS FOR THE CORPORATION TO BE IN THE CORPORATION'S
BEST INTERESTS AND RECOMMENDS A VOTE "FOR" SUCH RATIFICATION.
SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
Section 16(a) of the Securities Exchange Act of 1934 requires the
Corporation's officers and directors, and persons who own more than ten percent
of a registered class of the Corporation's equity securities, to file reports of
ownership and changes in ownership with the Securities and Exchange Commission
("SEC"). Officers, directors and greater than ten percent stockholders are
required by SEC regulations to furnish the Corporation with copies of all
Section 16(a) forms they file.
Based solely on the Corporation's review of such forms received by it, or
written representations from certain reporting persons that no Forms 5 were
required for such persons, the Corporation believes that, during the fiscal year
ended September 30, 1997, all filing requirements applicable to its officers,
directors and greater than ten percent beneficial owners were complied with,
except for the following: (i) a Form 5 was filed late by Mr. Browne with respect
to one transaction, Dr. Bruskin with respect to one transaction, Mr. Frashier
with respect to two transactions, Mr. French with respect to one transaction,
Dr. Goddard with respect to one transaction, Dr. Lovenberg with respect to one
transaction, Mr. Peltzman with respect to four transactions, Dr. Rose with
respect to three transactions, Mr. Van Nostrand with respect to four
transactions, and Mr. White with respect to one transaction; (ii) a Form 4 was
filed late by Dr. Bruskin with respect to one transaction, Dr. Goddard with
respect to one transaction and Mr. Takata with respect to one transaction; and
(iii) certain initial holdings of Dr. Granner were reported late.
16
<PAGE> 20
STOCKHOLDER PROPOSALS
Stockholders who intend to present proposals at the Corporation's Annual
Meeting of Stockholders to be held in 1999 must submit their proposals to the
Secretary of the Corporation on or before October 2, 1998. Such proposals must
also meet the other requirements of the rules of the SEC relating to
stockholders' proposals.
By Order of the Board of Directors,
ROBERT L. VAN NOSTRAND
Secretary
February 3, 1998
17
<PAGE> 21
________________________________________________________________________________
OSI PHARMACEUTICALS, INC.
PROXY
ANNUAL MEETING OF STOCKHOLDERS, MARCH 25, 1998
This Proxy is Solicited on Behalf of the Corporation's Board of Directors
The undersigned hereby appoints Gary E. Frashier and Robert L. Van
Nostrand, and each of them jointly and severally, Proxies, with full power of
substitution, to vote, as designated on the reverse side, all shares of Common
Stock of OSI Pharmaceuticals, Inc., formerly known as Oncogene Science, Inc.
(the "Corporation") held of record by the undersigned on January 26, 1998, at
the annual meeting of stockholders to be held on March 25, 1998, or any
adjournment thereof.
THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE ELECTION OF THE
NOMINEES TO SERVE AS DIRECTORS, AND "FOR" THE RATIFICATION OF THE APPOINTMENT
OF KPMG PEAT MARWICK LLP AS THE CORPORATION'S INDEPENDENT PUBLIC ACCOUNTANTS.
The shares represented by this Proxy will be voted as specified on the reverse
side. IF NO DIRECTION IS GIVEN IN THE SPACES PROVIDED ON THE REVERSE SIDE, THIS
PROXY WILL BE VOTED "FOR" ITEMS 1 AND 2.
(Continued and to be dated and signed on the reverse side.)
OSI PHARMACEUTICALS, INC.
P.O. BOX 11097
NEW YORK, N.Y. 10203-0097
________________________________________________________________________________
<PAGE> 22
________________________________________________________________________________
[ ]
<TABLE>
<S> <C> <C> <C>
1. Election of Directors (Term to FOR all nominees / / WITHHOLD AUTHORITY to vote / / EXCEPTIONS / /
expire at next Annual Meeting) Listed below for all nominees listed below
</TABLE>
Nominees: Gary E. Frashier, Edwin A. Gee, Ph.D., G. Morgan Browne, John H.
French, II, Daryl K. Granner, M.D., Walter M. Lovenberg, Ph.D.,
Steve M. Peltzman, John P. White.
(INSTRUCTIONS: To withhold authority to vote for any individual nominee, mark
the "Exceptions" box and write that nominee's name in the space provided
below.) THIS PROXY WILL BE VOTED FOR EACH NOMINEE FOR WHOM AUTHORITY TO VOTE
IS NOT WITHHELD.
"Exceptions _________________________________________________________________
2. PROPOSAL TO RATIFY THE APPOINTMENT OF 3. In their discretion, the Proxies
KPMG PEAT MARWICK LLP as the independent are authorized to vote upon such
public accountants of the Corporation other business as may properly
for the fiscal year ending September come before the meeting or any
30, 1998. adjournment thereof and matters
incident to the conduct of the
meeting.
FOR / / AGAINST / / ABSTAIN / /
Change of Address or / /
Comments Mark Here
Please sign exactly as the name appears
hereon. When shares are held by joint
tenants, both should sign. When signing
as attorney, executor, administrator,
trustee or guardian, please give full
title as such. If a corporation, please
sign in full corporate name by President
or other authorized officer and affix
corporate seal. If a partnership, please
sign in partnership name by general
partner.
Dated: __________________________, 1998
_________________________________ (SEAL)
Signature
_________________________________ (SEAL)
Signature if held jointly
Votes MUST be indicated /x/
(x) in Black or Blue ink.
(Please mark, sign, date and return this proxy in the enclosed postage prepaid
envelope.)
________________________________________________________________________________
