OSI PHARMACEUTICALS INC
10-K/A, 1999-01-27
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                 FORM 10-K/A
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
 
                            ------------------------
 
(MARK ONE)
[X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT
    OF 1934
 
                  FOR THE FISCAL YEAR ENDED SEPTEMBER 30, 1998
                                       OR
 
[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934
 
            FOR THE TRANSITION PERIOD FROM             TO
 
                          COMMISSION FILE NUMBER 0-15190
 
                             OSI PHARMACEUTICALS, INC.
              (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
 
<TABLE>
<S>                                              <C>
                    DELAWARE                                        13-3159796
        (STATE OR OTHER JURISDICTION OF                          (I.R.S. EMPLOYER
         INCORPORATION OR ORGANIZATION)                        IDENTIFICATION NO.)
 
  106 CHARLES LINDBERGH BLVD., UNIONDALE, N.Y.                        11553
    (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES)                        (ZIP CODE)
</TABLE>
 
       REGISTRANT'S TELEPHONE NUMBER, INCLUDING AREA CODE: (516) 222-0023
 
          SECURITIES REGISTERED PURSUANT TO SECTION 12(B) OF THE ACT:
 
<TABLE>
<S>                                              <C>
              TITLE OF EACH CLASS                   NAME OF EACH EXCHANGE ON WHICH REGISTERED
 
                      NONE                                             NONE
</TABLE>
 
          SECURITIES REGISTERED PURSUANT TO SECTION 12(G) OF THE ACT:
 
                     COMMON STOCK, PAR VALUE $.01 PER SHARE
                                (TITLE OF CLASS)
 
     Indicate by check mark whether the Registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
Registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.  Yes [X]  No [ ]
 
     Indicate by check mark if disclosure of delinquent filers pursuant to Item
405 of Regulation S-K is not contained herein, and will not be contained, to the
best of Registrant's knowledge, in definitive proxy or information statements
incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. [ ]
 
     As of November 30, 1998, the aggregate market value of the Registrant's
voting stock held by non-affiliates was $58,502,216. For purposes of this
calculation, shares of Common Stock held by directors, officers and stockholders
whose ownership exceeds five percent of the Common Stock outstanding at November
30, 1998 were excluded. Exclusion of shares held by any person should not be
construed to indicate that such person possesses the power, direct or indirect,
to direct or cause the direction of the management or policies of the
Registrant, or that such person is controlled by or under common control with
the Registrant.
 
     As of November 30, 1998, there were 21,410,995 shares of the Registrant's
Common Stock, par value $.01 per share, outstanding.
 
                      DOCUMENTS INCORPORATED BY REFERENCE
 
     Portions of the Registrant's definitive proxy statement for its 1999 annual
meeting of stockholders are incorporated by reference into Part III of this Form
10-K.
 
     This Form 10-K/A is being filed to amend the number of shares of the
Registrant's Common Stock outstanding as of November 30, 1998 as presented on
the cover page of the annual report on Form 10-K of OSI Pharmaceuticals, Inc.
for the fiscal year ended September 30, 1998, which was filed with the
Securities and Exchange Commission on December 23, 1998 (the "Form 10-K"). The
number of shares in the Form 10-K included treasury stock. This amendment
corrects the number of shares by subtracting treasury stock, equal to 897,838
shares, from the total number of shares outstanding as of November 30, 1998. 
This Form 10-K/A is also being filed to amend an incorrect reference to the 
Notes to the Consolidated Financial Statements in footnote (a) of Item 6, 
"Selected Consolidated Financial Data."   
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ITEM 6.  SELECTED CONSOLIDATED FINANCIAL DATA
 
     The following table sets forth selected consolidated financial data with
respect to the Company for each of the years in the five-year period ended
September 30, 1998. The information set forth below should be read in
conjunction with the consolidated financial statements and notes thereto
included elsewhere in this report.
 
<TABLE>
<CAPTION>
                                                 YEARS ENDED SEPTEMBER 30,
                           ----------------------------------------------------------------------
                             1998(a)        1997(b)        1996(c)        1995(d)       1994(e)
                           ------------   ------------   ------------   -----------   -----------
<S>                        <C>            <C>            <C>            <C>           <C>
Statement of Operations
  Data:
Revenues.................  $ 19,468,337   $ 14,777,323   $  9,718,437   $15,864,999   $16,299,489
Expenses:
  Research and
     development.........    20,350,063     16,896,617     13,918,968    13,523,043    12,125,210
  Production and service
     costs...............       955,464        635,768        134,529     1,252,990     1,427,981
  Selling, general and
     administrative......     8,076,662      7,424,265      6,314,697     7,140,208     7,487,090
  Amortization of
     intangibles.........     1,460,740      1,460,748      1,452,755     1,696,561     1,745,163
Loss from operations.....   (11,374,592)   (11,640,075)   (12,102,512)   (7,747,803)   (6,485,955)
Other income, net........     1,190,124      2,053,838      2,160,377       768,744       762,031
Gain on sale of Research
  Products Business......            --             --             --     2,720,389            --
Net loss.................   (10,184,468)    (9,586,237)    (9,942,135)   (4,258,670)   (5,723,924)
Basic loss per share.....         (0.48)         (0.44)         (0.50)        (0.25)        (0.35)
Weighted average number
  of shares of common
  stock outstanding......    21,372,655     21,604,344     19,712,274    16,757,370    16,335,000
                                                       SEPTEMBER 30,
                           ----------------------------------------------------------------------
                               1998           1997           1996          1995          1994
                           ------------   ------------   ------------   -----------   -----------
Balance Sheet Data:
Cash and short-term
  investments............  $ 24,418,281   $ 31,834,669   $ 47,542,745   $26,786,566   $18,157,891
Accounts receivable......     1,720,737      1,215,672      2,031,950     1,320,015     3,032,839
Working capital..........    22,268,346     29,612,616     47,181,407    26,127,781    21,208,145
Total assets.............    50,417,980     59,585,565     73,537,054    44,057,421    42,040,900
Stockholders' equity.....    43,059,246     52,944,868     68,286,959    40,549,636    38,656,314
</TABLE>
 
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(a) During fiscal 1998, the Company entered into collaborative agreements with
    Fujirebio and Vanderbilt, expanded its co-venture agreement with Anaderm,
    and entered into a license agreement with Aurora (See Notes 2, 5(c), 5(d),
    and 5(n) to the Consolidated Financial Statements).
 
(b) During fiscal 1997, the Company entered into collaborative agreements with
    Sankyo and Bayer, expanded its collaboration with HMRI, entered into
    co-venture agreements with Sepracor and Helicon, entered into a license
    agreement with Dow, and repurchased its Common Stock held by Becton,
    Dickinson and Company (See Notes 3(d), 5 and 9(a) to the Consolidated
    Financial Statements).
 
(c) During fiscal 1996, the Company acquired MYCOsearch and Aston and completed
    an offering of its Common Stock (See Notes 3 and 9(b) to the Consolidated
    Financial Statements).
 
(d) During fiscal 1995, the Company sold its Research Products Business and also
    sold shares of its Common Stock to Novartis.
 
(e) During fiscal 1994, the Company changed its method of accounting for
    marketable securities to adopt the provisions of the Statement of Financial
    Accounting Standards No. 115, "Accounting for Certain Investments in Debt
    and Equity Securities."
 
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                                  SIGNATURES





        Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, as amended, the Company has duly caused this report to be
signed on its behalf by the undersigned, thereunto duly authorized. 



                               OSI PHARMACEUTICALS, INC.
                              
                              
                               By: /s/ ROBERT L. VAN NOSTRAND
                                   ----------------------------
                                   Robert L. Van Nostrand
                                   Vice President and Chief Financial Officer

Date: January 27, 1999                                   


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