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<PAGE> 1 EXHIBIT 21 SUBSIDIARIES OF THE COMPANY OSI Pharmaceuticals, UK Ltd. (formerly Aston Molecules, Inc.), organized under the laws of the United Kingdom MYCOsearch Inc., incorporated under the laws of the State of Delaware Applied bioTechnology, Inc., incorporated under the laws of the State of Delaware OSDI, Inc. (formerly Oncogene Science Diagnostics, Inc.), incorporated under the laws of the State of Delaware
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