REPLIGEN CORP
10-K/A, 1995-08-18
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE> 1
===============================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 10-K/A

[X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
    ACT OF 1934

                    For the fiscal year ended March 31, 1995

                                       OR

[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
    EXCHANGE ACT OF 1934

    For the transition period from                   to                  
                                   -----------------    -----------------

                        Commission file number:  0-21700

                              REPLIGEN CORPORATION
-------------------------------------------------------------------------------
(Exact name of registrant as specified in its charter)

                  Delaware                                 04-2729386
--------------------------------------------  ---------------------------------
      (State or other jurisdiction of                   (I.R.S. Employer
       incorporation or organization)                  Identification No.)

One Kendall Square, Cambridge, Massachusetts                 02139
--------------------------------------------  ---------------------------------
  (Address of principal executive offices)                (Zip Code)

        Registrant's telephone number, including area code:  617-225-6000

Securities registered pursuant to Section 12(b) of the Act:

                                                    Name of each exchange
             Title of each class                     on which registered
--------------------------------------------  ---------------------------------

                    None                                     None

           Securities registered pursuant to Section 12(g) of the Act:

                          Common stock, $0.01 per share
-------------------------------------------------------------------------------
                                (Title of Class)

Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.  Yes  X   No    .
                                               ---     ---


<PAGE> 2

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405
of Regulation S-K is not contained herein, and will not be contained, to the
best of registrant's knowledge, in definitive proxy or information statements
incorporated by reference in Part III of this Form 10-K or any amendment to
this Form 10-K. 
                 ----------

State the aggregate market value of the voting stock held by non-affiliates of
the registrant.  The approximate aggregate market value, computed by reference
to the closing sale price of such stock quoted on NASDAQ on June 15, 1995 was
approximately $ 35,517,544.

Indicate the number of shares outstanding of each of the registrant's classes
of common stock as of June 15, 1995:  15,358,938.

===============================================================================










































<PAGE> 3

                                     PART IV

Item 14:     EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON
             FORM 8-K

Item 14(a)       The following documents are filed as part of this Annual
                 Report on Form 10-K:

Item 14(a)(1)    Financial Statements:  See "Index to Financial Statement and
                 Supplementary Data " in Item 8.

Item 14(a)(2)    Financial Statement Schedules:

    1.   Schedule II - Valuation and Qualifying Accounts 

         Other financial statement schedules have not been included because
they are not applicable or the information is included in financial statements
or notes thereto.

Item 14(a)(3)    Exhibits.

    The following is a list of exhibits filed as part of this Annual Report on
Form 10-K:

3.  Articles of Incorporation and By-laws

    3.1  --    Restated Certificate of Incorporation, dated June 30, 1992 and
               filed July 13, 1992 (filed as Exhibit 4.12 to Repligen
               Corporation's Annual Report on Form 10-K for the year ended
               March 31, 1993 and incorporated herein by reference).

    3.2  --    By-laws (filed as Exhibit 3.4 to Repligen Corporation's Form S-1
               Registration Statement No. 33-3959 and incorporated herein by
               reference).

4.  Instruments Defining the Rights of Security Holders

    4.1  --    Stockholder Agreement, dated May 29, 1981, among Dr. Alexander
               Rich, Dr. Paul Schimmel, and Dr. William M. Jackson and Repligen
               Corporation (filed as Exhibit 4.1  to Repligen Corporation's
               Form S-1 Registration Statement No. 33-3959 and incorporated
               herein by reference).

    4.2  --    Specimen Stock Certificate (filed as Exhibit 4.2 to Repligen
               Corporation's Form S-1 Registration Statement No. 33-3959 and
               incorporated herein by reference).

    4.3  --    Form of Subscription Documents for Series A Preferred Stock
               (filed as Exhibit 4.3 to Repligen Corporation's Form S-1
               Registration Statement No. 33-3959 and incorporated herein by
               reference).

    4.4  --    Form of Subscription Documents for Series B Preferred Stock
               (filed as Exhibit 4.4 to Repligen Corporation's Form S-1
               Registration Statement No. 33-3959 and incorporated herein by
               reference).


<PAGE> 4

    4.5  --    Common Stock Purchase Agreement, dated May 21, 1985, between The
               Gillette Company and Repligen Corporation (filed as Exhibit 4.5
               to Repligen Corporation's Form S-1 Registration Statement No.
               33-3959 and incorporated herein by reference).

    4.6  --    Common Stock Purchase Agreement, dated July 10, 1985, between
               Tiedemanns and Repligen Corporation (filed as Exhibit 4.6 to
               Repligen Corporation's Form S-1 Registration Statement No. 33-
               3959 and incorporated herein by reference).

    4.7  --    Purchase and Option Agreement dated as of March 31, 1987 between
               Centocor, Inc. and Repligen Corporation (filed as an Exhibit to
               Repligen Corporation's Form 8-K filed June 5, 1987 and
               incorporated herein by reference).

    4.8  --    Form of Limited Partner Warrant, dated as of February 28, 1992
               (filed as Exhibit 4.9 to Repligen Corporation's Annual Report on
               Form 10-K for the year ended March 31, 1992 and incorporated
               herein by reference).

    4.9  --    Form of Class B Limited Partner Warrant, dated as of February
               28, 1992 (filed as Exhibit 4.10 to Repligen Corporation's Annual
               Report on Form 10-K for the year ended March 31, 1992 and
               incorporated herein by reference).

    4.10 --    Form of Incentive Warrant, dated as of February 28, 1992 (filed
               as Exhibit 4.11 to Repligen Corporation's Annual Report on Form
               10-K for the year ended March 31, 1992 and incorporated herein
               by reference).

    4.11 --    Form of Fund Warrant, dated as of February 28, 1992 (filed as
               Exhibit 4.12 to Repligen Corporation's Annual Report on Form 10-
               K for the year ended March 31, 1992 and incorporated herein by
               reference).

    4.12 --    The 1992 Repligen Corporation Stock Option Plan (filed as
               Exhibit 4.12 to Repligen Corporation's Annual Report on Form 10-
               K for the year ended March 31, 1993 and incorporated herein by
               reference).
 
10. Material Contracts

    10.1  --   License Agreement, dated December 2, 1980, between the Trustees
               of Leland Stanford Junior University and Repligen Corporation
               (filed as Exhibit 10.1 to Repligen Corporation's Form S-1
               Registration Statement No. 33-3959 and incorporated herein by
               reference).

    10.2  --   Biological Supply Agreement, dated November 26, 1985, between
               Applied ImmuneSciences, Inc. and Repligen Corporation, with
               schedules (filed as Exhibit 10.5 to Repligen Corporation's Form
               S-1 Registration Statement No. 33-3959 and incorporated herein
               by reference).





<PAGE> 5

    10.3  --   Lease, dated August 15, 1984, between Robert A. Jones, K. George
               Najarian and David E. Clem, Trustees of Old Kendall Realty Trust
               and Repligen Corporation relating to premises located at One
               Kendall Square in Cambridge, Massachusetts (filed as Exhibit
               10.6 to Repligen Corporation's Form S-1 Registration Statement
               No. 33-3959 and incorporated herein by reference).

    10.4  --   Letter, dated December 30, 1985, from The First National Bank of
               Boston to Repligen Corporation establishing a $4,000,000 line of
               credit (filed as Exhibit 10.11 to Repligen Corporation's Form
               S-1 Registration Statement No. 33-3959 and incorporated herein
               by reference).

    10.5  --   Consulting Agreement, dated October 1, 1981, between Dr. Paul
               Schimmel and Repligen Corporation (filed as Exhibit 10.14 to
               Repligen Corporation's Form S-1 Registration Statement No. 33-
               3959 and incorporated herein by reference).

    10.6  --   Consulting Agreement, dated November 1, 1981, between Dr.
               Alexander Rich and Repligen Corporation (filed as Exhibit 10.15
               to Repligen Corporation's Form S-1 Registration Statement No.
               33-3959 and incorporated herein by reference).

    10.7  --   Purchase and Option Agreement, as amended, dated March 31, 1987,
               and Transfer, License and Collaborative Research Agreement,
               dated March 31, 1987, both between Centocor, Inc. and Repligen
               Corporation, (filed as an Exhibit to Repligen Corporation's Form
               8-K filed April 21, 1987 and incorporated herein by reference).

    10.8  --   Research Collaboration and License Agreement, dated May 26,
               1987, between Merck & Co., Inc. and Repligen Corporation (filed
               as an Exhibit to Repligen Corporation's Form 8-K filed June 5,
               1987 and incorporated herein by reference).

    10.9  --   Supply Agreement, dated May 26, 1987, between Merck and Co.,
               Inc. and Repligen Corporation (filed as an Exhibit to Repligen
               Corporation's Form 10-K filed June 29, 1987 and incorporated
               herein by reference).

    10.10 --   Letter, dated May 27, 1987, from The First National Bank of
               Boston to Repligen Corporation regarding a $4,000,000 line of
               credit (filed as an Exhibit to Repligen Corporation's Annual
               Report on Form 10-K filed June 29, 1987 and incorporated herein
               by reference).

    10.11 --   Amendment Agreement No. 6, dated April 1, 1989, between
               Centocor, Inc. and Repligen Corporation (filed as Exhibit 10.20
               to Repligen Corporation's Form 10-K Annual Report for the year
               ended December 31, 1988, between Centocor, Inc. and Repligen
               Corporation and incorporated herein by reference).

    10.12 --   National Institute of Allergy and Infectious Diseases grant no.
               [SRC (91)] 1-U01-AID28243-01 dated March 22, 1989 (filed as
               Exhibit 10.19 to Repligen Corporation's Annual Report on Form
               10-K for the year ended March 31, 1990 and incorporated herein
               by reference).


<PAGE> 6

    10.13 --   Lease Modification, dated January 6, 1989, among Robert A.
               Jones, K. George Najarian and David E. Clem, Trustees of Old
               Kendall Realty Trust and Repligen Corporation relating to
               premises located at One Kendall Square in Cambridge,
               Massachusetts (filed as Exhibit 10.23 to Repligen Corporation's
               Form 10-K Annual Report for the year ended December 31, 1988,
               and incorporated herein by reference).

    10.14 --   Purchase Agreement, dated October 2, 1989, between various
               selling shareholders of Repligen Corporation (filed as Exhibit
               28.1 to Repligen Corporation's Form S-3 Registration Statement
               No. 33-31705 and incorporated herein by reference).

    10.15 --   Sublicense Agreement, dated as of March 30, 1990, among Repligen
               Corporation and Cambridge BioScience Corporation (filed as
               Exhibit 10.24 to Repligen Corporation's Annual Report on Form
               10-K for the year ended March 31, 1990 and incorporated herein
               by reference).

    10.16 --   Amendment Agreement No. 7, dated March 31, 1990, between
               Centocor, Inc. and Repligen Corporation (filed as Exhibit 10.25
               to Repligen Corporation's Annual Report on Form 10-K for the
               year ended March 31, 1990 and incorporated herein by reference).

    10.17 --   Employment Agreement, dated August 28, 1986, between Sandford D.
               Smith and Repligen Corporation (filed as Exhibit 10.26 to
               Repligen Corporation's Annual Report on Form 10-K for the year
               ended March 31, 1990 and incorporated herein by reference).

    10.18 --   License Agreement, dated November 14, 1990, between the Regents
               of the University of Michigan and Repligen Corporation (filed as
               Exhibit 10.27 to Repligen Corporation's Annual Report on Form
               10-K for the year ended March 31, 1991 and incorporated herein
               by reference).

    10.19 --   Agreement and Plan of Merger, dated as of September 30, 1991, by
               and among Repligen Corporation, AI Acquisition Corp. and Amira,
               Inc. (filed as Exhibit 2.1 to Repligen Corporation's Form 8-K
               filed December 3, 1991 and incorporated herein by reference).

    10.20 --   Amendment No. 1 to Agreement and Plan of Merger, dated as of
               October 29, 1991, by and among Repligen Corporation, AI
               Acquisition Corp. and Amira, Inc. (filed as Exhibit 2.2 to
               Repligen Corporation's Form 8-K filed December 3, 1991 and
               incorporated herein by reference).

    10.21 --   Reacquisition Agreement, dated January 27, 1992, between
               Repligen Corporation and Merck & Co., Inc.  (filed as Exhibit
               10.28 to Repligen Corporation's Annual Report on Form 10-K for
               the year ended March 31, 1992 and incorporated herein by
               reference).

    10.22 --   Product Development Agreement, dated as of February 2, 1992,
               between Repligen Corporation and Repligen Clinical Partners,
               L.P.  (filed as Exhibit 10.29 to Repligen Corporation's Annual
               Report on Form 10-K for the year ended March 31, 1992 and
               incorporated herein by reference).

<PAGE> 7

    10.23 --   Purchase Agreement, dated February 2, 1992, between Repligen
               Corporation and each of the Limited Partners from time to time
               of Repligen Clinical Partners, L.P.  (filed as Exhibit 10.30 to
               Repligen Corporation's Annual Report on Form 10-K for the year
               ended March 31, 1992 and incorporated herein by reference).

    10.24 --   Asset Purchase Agreement, dated as of May 14, 1992, by and among
               Repligen Corporation, Abbott Biotech, Inc. and Abbott
               Laboratories (filed as Exhibit 10.1 to Repligen Corporation's
               Form 8-K filed May 29, 1992 and incorporated herein by
               reference).

    10.25 --   Lease, dated May 14, 1992, between Repligen Corporation and
               Damon Clinical Laboratories, Inc.  (filed as Exhibit 10.32 to 
               Repligen Corporation's Annual Report on Form 10-K for the year
               ended March 31, 1992 and incorporated herein by reference).

    10.26 --   Research, Collaboration and License Agreement, dated as of May
               16, 1992, by and between Repligen Corporation and Eli Lilly and
               Company (filed as Exhibit 10.33 to Repligen Corporation's Annual
               Report on Form 10-K for the year ended March 31, 1992 and
               incorporated herein by reference).

    10.27 --   Supply Agreement, dated as of May 15, 1992, by and between
               Repligen Corporation and Eli Lilly and Company (filed as Exhibit
               10.34 to Repligen Corporation's Annual Report on Form 10-K for
               the year ended March 31, 1992 and incorporated herein by
               reference).

    10.28 --   Stock Purchase Agreement, dated as of May 15, 1992, by and
               between  Repligen Corporation and Eli Lilly and Company (filed
               as Exhibit 10.35 to Repligen Corporation's Annual Report on Form
               10-K for the year ended March 31, 1992 and incorporated herein
               by reference).

    10.29 --   License Agreement, dated as of July 9, 1991, by and between
               Repligen Corporation and the Trustees of Boston University
               (filed as Exhibit 10.36 to Repligen Corporation's Annual Report
               on Form 10-K for the year ended March 31, 1992 and incorporated
               herein by reference).

    10.30 --   License Agreement, dated as of September 1, 1991, by and between
               Repligen Corporation and Kabi Pharmacia AB (filed as Exhibit
               10.37 to Repligen Corporation's Annual Report on Form 10-K for
               the year ended March 31, 1992 and incorporated herein by
               reference).

    10.31 --   Master Lease Agreement, dated as of October 30, 1992, between
               Comdisco Inc. and Repligen Corporation (filed as Exhibit 10.31
               to Repligen Corporation's Annual Report on Form 10-K for the
               year ended March 31, 1993 and incorporated herein by reference).

    10.32 --   Equipment Lease Agreement, dated December 31, 1992, between
               General Electric Capital Corporation and Repligen Corporation
               (filed as Exhibit 10.32 to Repligen Corporation's Annual  Report
               on Form 10-K for the year ended March 31, 1993 and incorporated
               herein by reference).

<PAGE> 8

    10.33 --   Stock Purchase Agreement, dated December 31, 1992, between
               Repligen Corporation, Sandoz Ltd., Sandoz Chemicals Corporation,
               Sandoz Pharma Ltd. and Repligen Sandoz Research Corporation
               (filed as Exhibit 10.33 to Repligen Corporation's Annual Report
               on Form 10-K for the year ended March 31, 1993 and incorporated
               herein by reference).

    10.34 --   Building Lease, dated April 15, 1993, among Robert A. Jones, K.
               George Najarian and David E. Clem, Trustees of Old Cambridge
               Realty Trust and Repligen Corporation, relating to premises
               located at One Kendall Square, Building 200, in Cambridge,
               Massachusetts (filed as Exhibit 10.34 to Repligen Corporation's
               Annual Report on Form 10-K for the year ended March 31, 1993 and
               incorporated herein by reference).

    10.35 --   Letter Agreement, dated April 30, 1993, between Merck and Co.,
               and Repligen Corporation, concerning Research Collaboration and
               License Agreement and Supply Agreement both dated as of May 26,
               1987 (filed as Exhibit 10.35 to Repligen Corporation's Annual
               Report on Form 10-K for the year ended March 31, 1993 and
               incorporated herein by reference).

    10.36 --   Term Loan Agreement, dated March 31, 1993, among Repligen
               Corporation and Amira, Inc., as Borrowers and the First National
               Bank of Boston (filed as Exhibit 10.36 to Repligen Corporation's
               Annual Report on Form 10-K for the year ended March 31, 1993 and
               incorporated herein by reference).

    10.37 --   Building Lease, dated July 10, 1992, between Trustees of the
               Cambridge East Trust and Amira, Inc., relating to 79 and 83
               Rogers Street, Cambridge, Massachusetts (filed as Exhibit 10.37
               to Repligen Corporation's Annual Report on Form 10-K for the
               year ended March 31, 1993 and incorporated herein by reference).

    10.38 --   Licensing Agreement, dated July 20, 1993, between Repligen
               Corporation and the Dana-Farber Cancer Institute, Inc. (filed as
               Exhibit 10.38 to Repligen Corporation's Form S-3 Registration
               Statement No. 33-72078 and incorporated herein by reference).

    10.39 --   Development and License Agreement, dated as of March 1, 1995,
               between Repligen Corporation and Eli Lilly and Company (omitting
               schedules and exhibits) (filed as Exhibit 10.39 to Repligen
               Corporation's Annual Report on Form 10-K for the year ended
               March 31, 1995 and incorporated herein by reference). <F1>

               <F1>  Confidential treatment requested.  Portions of this
                     document have been omitted by blocking out the relevant
                     text pursuant to an Application for Confidential
                     Treatment.  Such blocked out omissions have been filed
                     separately with the Securities and Exchange Commission. 
                     The Registrant shall furnish all omitted schedules and
                     exhibits to this document upon the request of the
                     Securities and Exchange Commission.

    10.40 --   Employment Agreement dated November 18, 1994 between Repligen
               Corporation and Dr. Leslie Hudson (filed as Exhibit 10.40 to
               Repligen Corporation's Annual Report on Form  10-K for the year
               ended March 31, 1995 and incorporated herein by reference).
<PAGE> 9

    10.41 --   Employment Agreement dated May 8, 1992 between Repligen
               Corporation and Avery W. Catlin (filed as Exhibit 10.41 to
               Repligen Corporation's Annual Report on Form 10-K for the year
               ended March 31, 1995 and incorporated herein by reference).

    22     --  Subsidiaries of Repligen Corporation (filed as Exhibit 22 to
               Repligen Corporation's Form S-3 Registration Statement No. 33-
               72078 and incorporated herein by reference).

    23     --  Consent of Independent Public Accountants.
         
    27     --  Financial Data Schedule

Item 14(b)     Reports on Form 8-K.

    No Current Reports on Form 8-K were filed by the Company during the last
quarter of the period covered by this report.









































<PAGE> 10

                                   SIGNATURES

    Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this amended report to be
signed on its behalf by the undersigned, thereunto duly authorized.

                                          REPLIGEN CORPORATION

                                          By: /s/ Sandford D. Smith
                                              ---------------------------------
                                              Sandford D. Smith, President
                                              and Chief Executive Officer
Date:  August 17, 1995













































<PAGE> 11
                                  EXHIBIT INDEX
                                  -------------

ITEM                               DESCRIPTION
----  -------------------------------------------------------------------------
27    Financial Data Schedule


<TABLE> <S> <C>

<ARTICLE>            5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FORM THE
FINANCIAL STATEMENTS FOR REPLIGEN CORPORATION AND IS QUALIFIED IN ITS ENTIRETY
BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<CIK>            0000730272
<NAME>           REPLIGEN CORPORATION
<MULTIPLIER>     1
       
<S>                             <C>
<PERIOD-TYPE>                   YEAR
<FISCAL-YEAR-END>                          MAR-31-1995
<PERIOD-START>                             APR-01-1994
<PERIOD-END>                               MAR-31-1995
<CASH>                                      13,821,387
<SECURITIES>                                 1,480,712
<RECEIVABLES>                                1,986,902
<ALLOWANCES>                                 (300,000)
<INVENTORY>                                  1,213,379
<CURRENT-ASSETS>                            24,823,938
<PP&E>                                      20,296,538
<DEPRECIATION>                            (15,312,326)
<TOTAL-ASSETS>                              31,329,953
<CURRENT-LIABILITIES>                       15,753,569
<BONDS>                                              0
<COMMON>                                       153,570
                                0
                                          0
<OTHER-SE>                                  15,422,814
<TOTAL-LIABILITY-AND-EQUITY>                31,329,953
<SALES>                                      3,884,642
<TOTAL-REVENUES>                            16,942,315
<CGS>                                        1,535,026
<TOTAL-COSTS>                               32,546,919
<OTHER-EXPENSES>                            16,345,713
<LOSS-PROVISION>                               440,031
<INTEREST-EXPENSE>                                   0
<INCOME-PRETAX>                           (31,950,317)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                       (31,950,317)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                              (31,950,317)
<EPS-PRIMARY>                                   (2.08)
<EPS-DILUTED>                                   (2.08)
        



</TABLE>


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