REPLIGEN CORP
SC 13D/A, 1997-01-03
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                   SECURITIES AND EXCHANGE COMMISSION
                         WASHINGTON, D.C.  20549 

                               SCHEDULE 13D
                            (Ammendment No.1)

                Under the Securities Exchange Act of 1934

                           Repligen Corporation   
                             (Name of Issuer)

                  Common Stock, par value $.01 per share
                     (Title of Class of Securities) 

                                759916109           
                              (CUSIP Number)

                  Paramount Capital Asset Management, Inc.
                      c/o Lindsay A. Rosenwald, M.D.
                              787 Seventh Avenue
                              New York, NY 10019
                                (212) 554-4300 

                             with a copy to:
                          David R. Walner, Esq.
                 Paramount Capital Asset Management, Inc.
                            787 Seventh Avenue
                             New York, NY 10019
                              (212) 554-4372
                         
        (Name, Address and Telephone Number of Person Authorized
        to Receive Notices and Communications) 

                           December 20, 1996        
         (Date of Event which Requires Filing of this Statement) 

        If the filing person has previously filed a statement on
        Schedule 13G to report the acquisition which is the
        subject of this Statement because of Rule 13d-1(b)(3) or
        (4), check the following:     
                                                          (X)

        Check the following box if a fee is being paid with this
        Statement:
                                                          (X)



                                       13D
      CUSIP NO. [759916109]                          PAGE ____ OF ___ PAGES

  1   NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Paramount Capital Asset Management, Inc.

  2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP 
                                                         (a)(X)
                                                         (b)(X) 

 3    SEC USE ONLY

 4    SOURCE OF FUNDS*
      OO (see Item 3 below)

 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO
      ITEM 2(d) or 2(e)
                                                                  (X)

 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      Delaware

                        7    SOLE VOTING POWER
                             None
       NUMBER OF
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           1,184,400
        OWNED BY
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON
          WITH          10   SHARED DISPOSITIVE POWER
                             1,184,400

 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      1,184,400

 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                  (X)

 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      7.5%

 14   TYPE OF REPORTING PERSON*
      CO 


                                      13D
      CUSIP NO. [759916109]                          PAGE ____ OF ___ PAGES

  1   NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Aries Domestic Fund, L.P.



  2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                         (a)(X)
                                                         (b)(X)
 3    SEC USE ONLY

 4    SOURCE OF FUNDS*
      OO (see Item 3 below)

 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO ITEM 2(d) or 2(e)
                                                            (X)

 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      Delaware

                        7    SOLE VOTING POWER
                             None
       NUMBER OF
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           361,700
        OWNED BY
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON
          WITH          10   SHARED DISPOSITIVE POWER
                             361,700

 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      361,700

 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                  (X)
 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      2.3%

 14   TYPE OF REPORTING PERSON*
      PN



                                    13D
      CUSIP NO. [759916109]                          PAGE ____ OF ___ PAGES

  1   NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      The Aries Trust
  2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                               (a)(X)
                                                               (b)(X) 

 3    SEC USE ONLY

 4    SOURCE OF FUNDS*
      OO (see Item 3 below)

 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO
      ITEM 2(d) or 2(e)
                                                                  (X)

 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      Cayman Islands

                        7    SOLE VOTING POWER
                             None
       NUMBER OF
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           822,700
        OWNED BY
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON
          WITH          10   SHARED DISPOSITIVE POWER
                             822,700

 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      822,700

 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                  (X)

 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      5.2%

 14   TYPE OF REPORTING PERSON*
      OO (see Item 2) 



                                    13D
      CUSIP NO. [759916109]                          PAGE ____ OF ___ PAGES

  1   NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Lindsay A. Rosenwald, M.D.

  2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                                               (a)(X)
                                                               (b)(X) 

 3    SEC USE ONLY

 4    SOURCE OF FUNDS*
      OO (see Item 3 below)

 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO
      ITEM 2(d) or 2(e)
                                                                  (X)

 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      United States

                        7    SOLE VOTING POWER
                             None
       NUMBER OF
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           1,184,400
        OWNED BY
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON
          WITH          10   SHARED DISPOSITIVE POWER
                             1,184,400

 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      1,184,400

 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                  (X)

 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      7.5%

 14   TYPE OF REPORTING PERSON*
      IN



Item 1.   Security and Issuer.

     (a)  Common Stock, $.01 par value ("Shares")

          Repligen Corporation
          117 Fourth Avenue
          Needham, MA 02194
          617-449-9560

Item 2.   Identity and Background.

     Names of Persons Filing:

     (a)  This statement is filed on behalf of Paramount Capital Asset
          Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
          ("Aries Domestic"), The Aries Trust ("Aries Trust") and Dr. Lindsay
          A. Rosenwald (collectively, "Reporting Parties").  See attached
          Exhibit A which is a copy of their agreement in writing to file
          this statement on behalf of each of them.

     (b)  The business address of Paramount Capital, Aries Domestic and Dr.
          Rosenwald s is 787 Seventh Avenue, 44th Floor, New York, New York,
          10019.  The business address for Aries Trust is c/o MeesPierson
          (Cayman) Limited, P.O. Box 2003, British American Centre, Phase 3,
          Dr. Roy's Drive, George Town, Grand Cayman.

     (c)  Dr. Rosenwald is an investment banker, venture capitalist, fund
          manager and sole shareholder of Paramount Capital,(1) a Subchapter S
          corporation incorporated in the State of Delaware. Paramount
          Capital is the General Partner of Aries Domestic,(2) a limited
          partnership incorporated in Delaware. Paramount Capital is the
          Investment Manager to Aries Trust,(3) a Cayman Islands Trust.

     (d)  Dr. Rosenwald, Paramount Capital, Aries Domestic and Aries Trust
          and their respective officers, directors, general partners,
          investment managers, or trustees have not, during the five years
          prior to the date hereof, been convicted in a criminal proceeding
          (excluding traffic violations or similar misdemeanors).

     (e)  Dr. Rosenwald, Paramount Capital, Aries Domestic and Aries Trust
          and their respective officers, directors, general partners,
          investment managers, or trustees have not been, during the five

__________________                   
1.   Please see attached Exhibit B indicating the executive
     officers and directors of Paramount Capital and providing
     information called for by Items 2-6 of this statement as to
     said officers and directors.  Exhibit B is herein
     incorporated by reference.

2.   Please see attached Exhibit C indicating the general partner of Aries
     Domestic and the general partner's executive officers and directors and
     providing information called for by Items 2-6 of this statement as to
     said general partners, officers and directors.  Exhibit C is herein
     incorporated by reference.

3.   Please see attached Exhibit D indicating the investment manager of the
     Aries Trust and the investment manager's executive officers and
     directors and providing information called for by Items 2-6 of this
     statement as to said investment manager and officers and directors.
     Exhibit D is herein incorporated by reference.


          years prior to the date hereof, parties to a civil proceeding of a
          judicial or administrative body of competent jurisdiction, as a
          result of which such person was or is subject to a judgment, decree
          or final order enjoining future violations of, or prohibiting or
          mandating activities subject to, Federal or State securities laws
          or finding any violation with respect to such laws.

     (f)  Dr. Rosenwald is a citizen of the United States.

Item 3.   Source and Amount of Funds or Other Consideration.

          As previously reported in the original statement on Schedule 13-D
          (the "Original Statement") filed by the Reporting Parties on
          November 15, 1996, in connection with their initial acquisition of
          shares of the Issuer, Aries Domestic used its general funds to
          effect the purchase of 292,000 shares of the Issuer in various open
          market transactions for an approximate aggregate purchase price of
          $407,258 and Aries Trust used its general funds to effect its
          initial purchase of 658,000 shares for an approximate aggregate
          purchase price of $916,692. Since the date of the Original
          Statement, Aries Domestic used its general funds to effect the
          purchase of an additional 69,700 shares of the Issuer in various
          open market transactions as further set forth in Item 5 for an
          approximate aggregate purchase price of $88,093 and the Aries Trust
          has used its general funds to effect the purchase of an additional
          164,700 shares of the Issuer in various open market transactions as
          further set forth in Item 5 for an approximate aggregate purchase
          price of $208,215.

Item 4.   Purpose of Transaction.

          The Reporting Parties acquired shares of Common Stock of the Issuer
          as an investment in the Issuer.

          Although the Reporting Parties have not formulated any definitive
          plans, they may from time to time acquire, or dispose of, Common
          Stock and/or other securities of the Issuer if and when they deem
          it appropriate.  The Reporting Parties may formulate other
          purposes, plans or proposals relating to any of such securities of
          the Issuer to the extent deemed advisable in light of market
          conditions, investment policies and other factors.

          Except as indicated in this Schedule 13D, the Reporting Parties
          currently have no plans or proposals that relate to or would result
          in any of the matters described in subparagraphs (a) through (j) of
          Item 4 of Schedule 13D.

Item 5.   Interest in Securities of the Issuer.

          (a)  As of December 27, 1996, Dr. Rosenwald and Paramount Capital,
               through acquisition of the shares by the Aries Trust and Aries
               Domestic, beneficially owned 1,184,400 shares or 7.5% of the
               Issuer's securities and Aries Domestic and the Aries Trust
               beneficially owned as follows:

                                        Amount Owned
               Aries Domestic             361,700 Shares
               Aries Trust                822,700 Shares

          (b)  Dr. Rosenwald and Paramount Capital share the power to vote or
               to direct the vote, to dispose or to direct the disposition of
               those shares owned by each of Aries Domestic and Aries Trust.


          (c)  The following purchases were made by Aries Domestic in the
               open market since the filing of the Original Statement on
               December 4, 1996:

               Date           No. of Shares       Purchase Price
               12/05/96             7,500              1.313
               12/06/96             7,500              1.375
               12/11/96            15,000              1.205
               12/12/96             3,000              1.219
               12/16/96            10,800              1.250
               12/20/96             2,400              1.139
               12/23/96            17,400              1.197
               12/24/96             1,500              1.170
               12/26/96             4,600              1.125

               The following purchases were made by Aries Trust in the open
               market in the since the filing of the Original Statement on
               December 4, 1996:

                   Date       No. of Shares       Market Price
               12/05/96            17,500              1.313
               12/06/96            17,500              1.375
               12/11/96            40,000              1.205
               12/12/96             6,200              1.219
               12/16/96            25,000              1.250
               12/20/96             7,000              1.139
               12/23/96            41,000              1.197
               12/24/96             3,500              1.170
               12/26/96             7,000              1.125

               Other than as set forth herein the Reporting Parties have not
               engaged in any transactions in the Common Stock of the Issuer
               during the past 60 days.

          (d) & (e) Not applicable.

Item 6.   Contracts, Arrangements, Understandings or Relationships
          with respect to Securities of the Issuer                

          Paramount Capital is the investment manager of the Aries Trust and
          the General Partner of Aries Domestic and in such capacities has
          the authority to make certain investment decisions on behalf of
          such entities, including decisions relating to the securities of
          the Issuer.  In connection with its investment management duties,
          Paramount Capital receives certain management fees and performance
          allocations from the Aries Trust and Aries Domestic.  Dr. Rosenwald
          is the sole shareholder of Paramount Capital.  Except as indicated
          in this 13D and exhibits, there is no contract, arrangement,
          understanding or relationship between the Reporting Parties and any
          other person, with respect to any securities of the Issuer. 

Item 7.   Material to be Filed as Exhibits:

Exhibit A -    Copy of an Agreement between Dr. Rosenwald, Paramount Capital,
               Aries Domestic and Aries Trust to file this Statement on
               Schedule 13D on behalf of each of them.  

Exhibit B -    List of executive officers and directors of Paramount Capital
               and information called for by Items 2-6 of this statement
               relating to said officers and directors.


Exhibit C -    List of executive officers and directors of Aries Domestic and
               information called for by Items 2-6 of this statement relating
               to said officers and directors.

Exhibit D -    List of executive officers and directors of Aries Trust and
               information called for by Items 2-6 of this statement relating
               to said officers and directors.  

                                  SIGNATURES

          After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:    December 20, 1996
          New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                    Lindsay A. Rosenwald, M.D.
                                    President

                                  ARIES DOMESTIC FUND, L.P.
                                  By  Paramount Capital Asset Management, Inc.
                                      General Partner

Dated:    December 20, 1996
          New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                    Lindsay A. Rosenwald, M.D.
                                    President

                                  THE ARIES TRUST
                                  By Paramount Capital Asset Management, Inc.
                                  Investment Manager

Dated:    December 20, 1996
          New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                    Lindsay A. Rosenwald, M.D.
                                    President

Dated:    December 20, 1996
          New York, NY           By  /s/ Lindsay A. Rosenwald, M.D. 
                                     Lindsay A. Rosenwald, M.D.



                                  EXHIBIT A

                                  AGREEMENT

                         JOINT FILING OF SCHEDULE 13D

          The undersigned hereby agrees to jointly prepare and file with
regulatory authorities a Schedule 13D and any future amendments thereto
reporting each of the undersigned's ownership of securities of Repligen
Corporation, and hereby affirm that such Schedule 13D is being filed on
behalf of each of the undersigned.

                                 PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:    December 20, 1996
          New York, NY            By /s/ Lindsay A. Rosenwald. M.D.  
                                    Lindsay A. Rosenwald, M.D.
                                    President

                                  ARIES DOMESTIC FUND, L.P.
                                  By Paramount Capital Asset Management, Inc.
                                  General Partner

Dated:    December 20, 1996
          New York, NY            By /s/ Lindsay A. Rosenwald   M.D.
                                    Lindsay A. Rosenwald, M.D.
                                    President

                                  THE ARIES TRUST
                                  By Paramount Capital Asset Management, Inc.
                                  Investment Manager

Dated:    December 20, 1996
          New York, NY            By /s/ Lindsay A. Rosenwald, M.D.
                                    Lindsay A. Rosenwald, M.D.
                                    President

Dated:    December 20, 1996
          New York, NY           By  /s/ Lindsay Rosenwald, M.D.  
                                     Lindsay A. Rosenwald, M.D.



                                  EXHIBIT B

     The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management, Inc. ("Paramount Capital")
located at 787 Seventh Avenue, 44th Floor, New York, New York, 10019, of each
executive officer and director of Paramount Capital is as follows:

                                             PRINCIPAL OCCUPATION
     NAME                                       OR EMPLOYMENT

Lindsay A. Rosenwald, M.D.                   Chairman of the Board, President
                                             of Paramount Capital Asset
                                             Management, Inc., Paramount
                                             Capital Investments LLC and
                                             Paramount Capital, Inc.

Peter Morgan Kash                            Director of Paramount Capital
                                             Asset Management, Inc., Inc.,
                                             Senior Managing Director,
                                             Paramount Capital, Inc.

Dr. Yuichi Iwaki                             Director of Paramount Capital
                                             Asset Management, Inc., Inc.,
                                             Professor, University of
                                             Southern California School of
                                             Medicine

Item 2.

     During the five years prior to the date hereof, none of the above
persons (to the best of Paramount Capital s knowledge) was convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors) or
was a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction, as a result of which such person was or is subject to
a judgment, decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, Federal or State securities
laws or finding any violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.



                                  EXHIBIT C

     The name and principal occupation or employment of the General Partner
of Aries Domestic, which is located at 787 Seventh Avenue, 44th Floor, New
York, New York, 10019, is as follows:

                                             PRINCIPAL OCCUPATION
     NAME                                       OR EMPLOYMENT

Paramount Capital Asset Management, Inc.    General Partner; Investment Manager

     Exhibit B is hereby incorporated by reference.

Item 2.

     During the five years prior to the date hereof, the above person (to the
best of Aries Domestic's knowledge) has not been convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a
party to a civil proceeding of a judicial or administrative body of competent
jurisdiction, as a result of which such person was or is subject to a
judgment, decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, Federal or State securities
laws or finding any violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.



                                  EXHIBIT D

     The name and principal occupation or employment, which in the case of
Paramount Capital Asset Management, Inc. is located at 787 Seventh Avenue,
44th Floor, New York, New York, 10019, of each executive officer and director
of Aries Trust is as follows:

                                             PRINCIPAL OCCUPATION
     NAME                                       OR EMPLOYMENT

Paramount Capital Asset Management, Inc.     Investment Manager

MeesPierson (Cayman) Limited                 Trustee
P.O. Box 2003
British American Centre
Phase 3, Dr. Roy s Drive
George Town, Grand Caymen 

     Exhibit B is hereby incorporated by reference.

Item 2.

     During the five years prior to the date hereof, neither of the above
persons (to the best of Aries Trust's knowledge) have been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors) or
was a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction, as a result of which such person was or is subject to
a judgment, decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, Federal or State securities
laws or finding any violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.





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