REPLIGEN CORP
SC 13D/A, 1997-04-24
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                     SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549


                                SCHEDULE 13D
                              (Amendment No.5)

                 Under the Securities Exchange Act of 1934


                            Repligen Corporation
                      --------------------------------
                              (Name of Issuer)


                   Common Stock, par value $.01 per share
                   --------------------------------------
                       (Title of Class of Securities)


                                 759916109
                          -----------------------
                               (CUSIP Number)


                  Paramount Capital Asset Management, Inc.
                       c/o Lindsay A. Rosenwald, M.D.
                             787 Seventh Avenue
                             New York, NY 10019
                               (212) 554-4300

                              with a copy to:

                           David R. Walner, Esq.
                  Paramount Capital Asset Management, Inc.
                             787 Seventh Avenue
                             New York, NY 10019
                               (212) 554-4372
                  ----------------------------------------
          (Name, Address and Telephone Number of Person Authorized
                   to Receive Notices and Communications)


                               April 14, 1997
                            -------------------
          (Date of Event which Requires Filing of this Statement)



        If the filing person has previously filed a statement on
        Schedule 13G to report the acquisition which is the
        subject of this Statement because of Rule 13d-1(b)(3) or
        (4), check the following:     
                                                          ( )

        Check the following box if a fee is being paid with this
        Statement:
                                                          ( )



                                    13D
      CUSIP NO. [759916109]     
 --------------------------------------------------------------------------
 1    NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Paramount Capital Asset Management, Inc.
 --------------------------------------------------------------------------
 2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP   
                                                               (a)( )
                                                               (b)( )
 --------------------------------------------------------------------------
 3    SEC USE ONLY

 --------------------------------------------------------------------------
 4    SOURCE OF FUNDS*
      OO (see Item 3 below)
 --------------------------------------------------------------------------
 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO ITEM 2(d) or 2(e)
                                                                   ( )
 --------------------------------------------------------------------------
 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      Delaware
 --------------------------------------------------------------------------
                        7    SOLE VOTING POWER
                             None
       NUMBER OF        ---------------------------------------------------
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           1,934,800
        OWNED BY        ---------------------------------------------------
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON         ---------------------------------------------------
          WITH          10   SHARED DISPOSITIVE POWER
                             1,934,800
 --------------------------------------------------------------------------
 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      1,934,800
 --------------------------------------------------------------------------
 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                    ( )
 --------------------------------------------------------------------------
 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      12.1%
 --------------------------------------------------------------------------
 14   TYPE OF REPORTING PERSON*
      CO
 --------------------------------------------------------------------------



                                    13D
      CUSIP NO. [759916109]
 --------------------------------------------------------------------------
 1    NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Aries Domestic Fund, L.P.
 --------------------------------------------------------------------------
 2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                (a)( )
                                                                (b)( )
 --------------------------------------------------------------------------
 3    SEC USE ONLY

 --------------------------------------------------------------------------
 4    SOURCE OF FUNDS*
      OO (see Item 3 below)
 --------------------------------------------------------------------------
 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO ITEM 2(d) or 2(e)
                                                                  ( )
 --------------------------------------------------------------------------
 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      Delaware
 --------------------------------------------------------------------------
                        7    SOLE VOTING POWER
                             None
       NUMBER OF        ---------------------------------------------------
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           622,000
        OWNED BY        ---------------------------------------------------
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON         ---------------------------------------------------
          WITH          10   SHARED DISPOSITIVE POWER
                             622,000
 --------------------------------------------------------------------------
 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      622,000
 --------------------------------------------------------------------------
 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                  ( )
 --------------------------------------------------------------------------
 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      3.9%
 --------------------------------------------------------------------------
 14   TYPE OF REPORTING PERSON*
      PN
 --------------------------------------------------------------------------



                                    13D
      CUSIP NO. [759916109]
 --------------------------------------------------------------------------
 1    NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      The Aries Trust
 --------------------------------------------------------------------------
 2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                               (a)( )
                                                               (b)( )
 --------------------------------------------------------------------------
 3    SEC USE ONLY

 --------------------------------------------------------------------------
 4    SOURCE OF FUNDS*
      OO (see Item 3 below)
 --------------------------------------------------------------------------
 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO ITEM 2(d) or 2(e)
                                                                  ( )
 --------------------------------------------------------------------------
 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      Cayman Islands
 --------------------------------------------------------------------------
                        7    SOLE VOTING POWER
                             None
       NUMBER OF        ---------------------------------------------------
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           1,317,300
        OWNED BY        ---------------------------------------------------
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON         ---------------------------------------------------
          WITH          10   SHARED DISPOSITIVE POWER
                             1,317,300
 --------------------------------------------------------------------------
 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      1,317,300
 --------------------------------------------------------------------------
 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                  ( )
 --------------------------------------------------------------------------
 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      8.2%
 --------------------------------------------------------------------------
 14   TYPE OF REPORTING PERSON*
      OO (see Item 2)
 --------------------------------------------------------------------------



                                    13D
      CUSIP NO. [759916109]
 --------------------------------------------------------------------------
 1    NAMES OF REPORTING PERSONS
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

      Lindsay A. Rosenwald, M.D.
 --------------------------------------------------------------------------
 2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                               (a)( )
                                                               (b)( )
 --------------------------------------------------------------------------
 3    SEC USE ONLY

 --------------------------------------------------------------------------
 4    SOURCE OF FUNDS*
      OO (see Item 3 below)
 --------------------------------------------------------------------------
 5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
      PURSUANT TO ITEM 2(d) or 2(e)
                                                                  ( )
 --------------------------------------------------------------------------
 6    CITIZENSHIP OR PLACE OF ORGANIZATION
      United States
 --------------------------------------------------------------------------
                        7    SOLE VOTING POWER
                             None
       NUMBER OF        ---------------------------------------------------
         SHARES         8    SHARED VOTING POWER
      BENEFICIALLY           1,934,800
        OWNED BY        ---------------------------------------------------
          EACH          9    SOLE DISPOSITIVE POWER
       REPORTING             None
         PERSON         ---------------------------------------------------
          WITH          10   SHARED DISPOSITIVE POWER
                             1,934,800
 --------------------------------------------------------------------------
 11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      1,934,800
 --------------------------------------------------------------------------
 12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
      SHARES*
                                                                  ( )
 --------------------------------------------------------------------------
 13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      12.1%
 --------------------------------------------------------------------------
 14   TYPE OF REPORTING PERSON*
      IN
 --------------------------------------------------------------------------



Item 1.   Security and Issuer.

     (a)  Common Stock, $.01 par value ("Shares")

          Repligen Corporation
          117 Fourth Avenue
          Needham, MA 02194
          617-449-9560

Item 2.   Identity and Background.

     Names of Persons Filing:

     (a)  This statement is filed on behalf of Paramount Capital Asset
          Management, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
          ("Aries Domestic"), The Aries Trust ("Aries Trust") and Lindsay
          A. Rosenwald, M.D. ( Dr. Rosenwald and collectively with
          Paramount Capital, Aries Domestic and Aries Trust, the "Reporting
          Parties"). See attached Exhibit A which is a copy of their
          agreement in writing to file this statement on behalf of each of
          them.

     (b)  The business address of Paramount Capital, Aries Domestic and Dr.
          Rosenwald is 787 Seventh Avenue, New York, New York, 10019. The
          business address for Aries Trust is c/o MeesPierson (Cayman)
          Limited, P.O. Box 2003, British American Centre, Phase 3, Dr.
          Roy's Drive, George Town, Grand Cayman.

     (c)  Dr. Rosenwald is an investment banker, venture capitalist, fund
          manager and sole shareholder of Paramount Capital,(1) a Subchapter
          S corporation incorporated in the State of Delaware. Paramount
          Capital is the General Partner of Aries Domestic,(2) a limited
          partnership incorporated in Delaware. Paramount Capital is the
          Investment Manager to Aries Trust,(3) a Cayman Islands Trust.

 ---------------------------
     1    Please see attached Exhibit B indicating the executive
          officers and directors of Paramount Capital and providing
          information called for by Items 2-6 of this statement as to
          said officers and directors.  Exhibit B is herein
          incorporated by reference.

     2    Please see attached Exhibit C indicating the general partner of
          Aries Domestic and the general partner's executive officers and
          directors and providing information called for by Items 2-6 of
          this statement as to said general partners, officers and
          directors. Exhibit C is herein incorporated by reference.

     3    Please see attached Exhibit D indicating the investment manager
          of the Aries Trust and the investment manager's executive
          officers and directors and providing information called for by
          Items 2-6 of this statement as to said investment manager and
          officers and directors. Exhibit D is herein incorporated by
          reference.


     (d)  The Reporting Parties and their respective officers, directors,
          general partners, investment managers, or trustees have not,
          during the five years prior to the date hereof, been convicted in
          a criminal proceeding (excluding traffic violations or similar
          misdemeanors).

     (e)  The Reporting Parties and their respective officers, directors,
          general partners, investment managers, or trustees have not been,
          during the five years prior to the date hereof, parties to a
          civil proceeding of a judicial or administrative body of
          competent jurisdiction, as a result of which such person was or
          is subject to a judgment, decree or final order enjoining future
          violations of, or prohibiting or mandating activities subject to,
          Federal or State securities laws or finding any violation with
          respect to such laws.

     (f)  Dr. Rosenwald is a citizen of the United States.

Item 3.   Source and Amount of Funds or Other Consideration.

          As previously reported in the original statement on Schedule 13-D
          (the "Original Statement") filed by the Reporting Parties on
          November 15, 1996, in connection with their initial acquisition
          of shares of the Issuer, Aries Domestic used its general funds to
          effect the purchase of 292,000 shares of the Issuer in various
          open market transactions for an approximate aggregate purchase
          price of $407,258 and Aries Trust used its general funds to
          effect its initial purchase of 658,000 shares for an approximate
          aggregate purchase price of $916,692. As of the date of the last
          filing of a Schedule 13D Amendment ( Amendment No. 4"), Aries
          Domestic beneficially owned 563,000 shares of the Issuer and the
          Aries Trust beneficially owned 1,211,800 shares of the Issuer.
          Since the date of Amendment No. 4, the Reporting Parties used
          their general funds to effect the purchase of the securities of
          Issuer in various open market transactions as further set forth
          in Item 5.

Item 4.   Purpose of Transaction.

          The Reporting Parties have acquired shares of Common Stock of the
          Issuer as an investment in the Issuer.

          Although the Reporting Parties have not formulated any definitive
          plans, they may from time to time acquire, or dispose of, Common
          Stock and/or other securities of the Issuer if and when they deem
          it appropriate. The Reporting Parties may formulate other
          purposes, plans or proposals relating to any of such securities
          of the Issuer to the extent deemed advisable in light of market
          conditions, investment policies and other factors.

          Except as indicated in this Schedule 13D, the Reporting Parties
          currently have no plans or proposals that relate to or would
          result in any of the matters described in subparagraphs (a)
          through (j) of Item 4 of Schedule 13D.

Item 5.   Interest in Securities of the Issuer.

          (a)  As of April 14, 1997, Dr. Rosenwald and Paramount Capital,
               through acquisition of the shares by the Aries Trust and
               Aries Domestic, beneficially owned 1,934,800 shares or 12.1%
               of the Issuer's securities and Aries Domestic and the Aries
               Trust beneficially owned as follows:

                                        Amount Owned
                                        ------------
               Aries Domestic             622,500 shares
               Aries Trust              1,317,300 shares

          (b)  Dr. Rosenwald and Paramount Capital share the power to vote
               or to direct the vote, to dispose or to direct the
               disposition of those shares owned by each of Aries Domestic
               and Aries Trust.

          (c)  The following purchases were made by Aries Domestic in the
               open market since the filing of Amendment No. 4:

               Date           No. of Shares       Purchase Price
               ----           -------------       --------------
               3/31/97           42,500               1.468
               4/04/97            3,500               1.156
               4/11/97            5,000               1.187
               4/14/97            3,500               1.156

               The following purchases were made by Aries Trust in the open
               market in the since the filing of Amendment No. 4:

               Date           No. of Shares       Market Price
               ----           -------------       ------------
               3/31/97            42,500              1.468
               4/04/97             3,500              1.156
               4/11/97             5,000              1.187
               4/14/97             3,500              1.156

               Other than as set forth herein the Reporting Parties have
               not engaged in any transactions in the Common Stock of the
               Issuer during the past 60 days.

          (d) & (e) Not applicable.

Item 6.   Contracts, Arrangements, Understandings or Relationships
          with respect to Securities of the Issuer                

          Paramount Capital is the investment manager of the Aries Trust
          and the General Partner of Aries Domestic and in such capacities
          has the authority to make certain investment decisions on behalf
          of such entities, including decisions relating to the securities
          of the Issuer. In connection with its investment management
          duties, Paramount Capital receives certain management fees and
          performance allocations from the Aries Trust and Aries Domestic.
          Dr. Rosenwald is the sole shareholder of Paramount Capital.
          Except as indicated in this 13D and exhibits, there is no
          contract, arrangement, understanding or relationship between the
          Reporting Parties and any other party or parties, with respect to
          any securities of the Issuer.

Item 7.   Material to be Filed as Exhibits:

Exhibit A - Copy of an Agreement between Dr. Rosenwald, Paramount Capital,
            Aries Domestic and Aries Trust to file this Statement on
            Schedule 13D on behalf of each of them.

Exhibit B - List of executive officers and directors of Paramount Capital
            and information called for by Items 2-6 of this statement
            relating to said officers and directors.

Exhibit C - List of executive officers and directors of Aries Domestic and
            information called for by Items 2-6 of this statement relating
            to said officers and directors.

Exhibit D - List of executive officers and directors of Aries Trust and
            information called for by Items 2-6 of this statement relating
            to said officers and directors.



                                 SIGNATURES

          After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.
Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                     -------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


                                  ARIES DOMESTIC FUND, L.P.
                                  By: Paramount Capital Asset Management,
                                        Inc.
                                      General Partner
Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                     -------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


                                  THE ARIES TRUST
                                  By: Paramount Capital Asset Management,
                                        Inc.
                                      Investment Manager
Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                     -------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald, M.D. 
                                     --------------------------------------
                                      Lindsay A. Rosenwald, M.D.




                                 EXHIBIT A

                                 AGREEMENT

                        JOINT FILING OF SCHEDULE 13D

          The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13D and any future amendments thereto
reporting each of the undersigned's ownership of securities of Repligen
Corporation, and hereby affirm that such Schedule 13D is being filed on
behalf of each of the undersigned.


                                 PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.
Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald. M.D.  
                                     ------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


                                  ARIES DOMESTIC FUND, L.P.
                                  By: Paramount Capital Asset Management,
                                        Inc.
                                      General Partner
Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald   M.D.
                                     -------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


                                  THE ARIES TRUST
                                  By: Paramount Capital Asset Management,
                                        Inc.
                                      Investment Manager
Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------
                                     Lindsay A. Rosenwald, M.D.
                                     President


Dated:    April 16, 1997
          New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.  
                                     ------------------------------------
                                      Lindsay A. Rosenwald, M.D.




                                  EXHIBIT B

     The name and principal occupation or employment, which in each
instance is with Paramount Capital Asset Management, Inc. ("Paramount
Capital") located at 787 Seventh Avenue, 44th Floor, New York, New York,
10019, of each executive officer and director of Paramount Capital is as
follows:

                                           PRINCIPAL OCCUPATION
     NAME                                     OR EMPLOYMENT
     ----                                  --------------------
Lindsay A. Rosenwald, M.D.                 Chairman of the Board, President
                                           of Paramount Capital Asset
                                           Management, Inc., Paramount
                                           Capital Investments, LLC and
                                           Paramount Capital, Inc.

Peter Morgan Kash                          Director of Paramount Capital
                                           Asset Management, Inc., Senior
                                           Managing Director, Paramount
                                           Capital, Inc.

Dr. Yuichi Iwaki                           Director of Paramount Capital
                                           Asset Management, Inc.,
                                           Professor, University of
                                           Southern California School of
                                           Medicine

Item 2.

     During the five years prior to the date hereof, none of the above
persons (to the best of Paramount Capital's knowledge) has been convicted
in a criminal proceeding (excluding traffic violations or similar
misdemeanors) or was a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction, as a result of which such
person was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to,
Federal or State securities laws or finding any violation with respect to
such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.




                                 EXHIBIT C

     The name and principal occupation or employment of the General Partner
of Aries Domestic, which is located at 787 Seventh Avenue, New York, New
York, 10019, is as follows:

                                             PRINCIPAL OCCUPATION
     NAME                                       OR EMPLOYMENT
     ----                                    --------------------
Paramount Capital Asset Management, Inc.     General Partner; Investment
                                               Manager

     Exhibit B is hereby incorporated by reference.

Item 2.

     During the five years prior to the date hereof, the above person (to
the best of Aries Domestic's knowledge) has not been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors)
or was a party to a civil proceeding of a judicial or administrative body
of competent jurisdiction, as a result of which such person was or is
subject to a judgment, decree or final order enjoining future violations
of, or prohibiting or mandating activities subject to, Federal or State
securities laws or finding any violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.




                                  EXHIBIT D

     The name and principal occupation or employment, which in the case of
Paramount Capital Asset Management, Inc. is located at 787 Seventh Avenue,
44th Floor, New York, New York, 10019, of each executive officer and
director of Aries Trust is as follows:

                                             PRINCIPAL OCCUPATION
     NAME                                       OR EMPLOYMENT
     ----                                    --------------------
Paramount Capital Asset Management, Inc.     Investment Manager

MeesPierson (Cayman) Limited                 Trustee
P.O. Box 2003
British American Centre
Phase 3, Dr. Roy's Drive
George Town, Grand Cayman 

     Exhibit B is hereby incorporated by reference.

Item 2.

     During the five years prior to the date hereof, neither of the above
persons (to the best of Aries Trust's knowledge) have been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors)
or was a party to a civil proceeding of a judicial or administrative body
of competent jurisdiction, as a result of which such person was or is
subject to a judgment, decree or final order enjoining future violations
of, or prohibiting or mandating activities subject to, Federal or State
securities laws or finding any violation with respect to such laws.

Items 3-6.

     Please refer to Items 3-6 herein reporting the beneficial ownership.





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