REPLIGEN CORP
SC 13D/A, 1997-07-02
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13D
                                (Amendment No.6)

                    Under the Securities Exchange Act of 1934


                              Repligen Corporation
                              --------------------
                                (Name of Issuer)


                     Common Stock, par value $.01 per share
                     --------------------------------------
                         (Title of Class of Securities)

                                    759916109
                                    ---------
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300

                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372

       (Name, Address and Telephone Number of Person Authorized to Receive
                           Notices and Communications)


                                  June 24, 1997
             (Date of Event which Requires Filing of this Statement)



                                        1

<PAGE>
                                     
If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following: [  ]

Check the following box if a fee is being paid with this Statement:  [  ]




                                        2

<PAGE>
                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 3 of 15 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Paramount Capital Asset Management, Inc.         
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|
                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          2,112,700
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        2,112,700
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         2,112,700
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         13.1%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------

<PAGE>

                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 4 of 15 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Aries Domestic Fund, L.P.         
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|
                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          678,600
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        678,600
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         678,600
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         4.2%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------

<PAGE>

                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 5 of 15 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         The Aries Trust         
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|
                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          1,434,100
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        1,434,100
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         1,434,100
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         8.9%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------

<PAGE>
                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 6 of 15 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    |_|
                                                          (b)    |_|
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          |_|
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          2,112,700
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        2,112,700
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         2,112,700
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  |_|
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         13.1%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------

<PAGE>

Item 1. Security and Issuer.

     (a)  Common Stock, $.01 par value ("Shares")

          Repligen Corporation
          117 Fourth Avenue
          Needham, MA 02194
          617-449-9560

Item 2. Identity and Background.

         Names of Persons Filing:

     (a)  This  statement  is  filed  on  behalf  of  Paramount   Capital  Asset
          Management,  Inc.  ("Paramount  Capital"),  Aries Domestic Fund,  L.P.
          ("Aries  Domestic"),  The Aries Trust  ("Aries  Trust") and Lindsay A.
          Rosenwald,  M.D.  ("Dr.  Rosenwald"  and  collectively  with Paramount
          Capital, Aries Domestic and Aries Trust, the "Reporting Parties"). See
          attached  Exhibit A which is a copy of their  agreement  in writing to
          file this statement on behalf of each of them.

     (b)  The business  address of  Paramount  Capital,  Aries  Domestic and Dr.
          Rosenwald  is 787  Seventh  Avenue,  New York,  New York,  10019.  The
          business address for Aries Trust is c/o MeesPierson  (Cayman) Limited,
          P.O.  Box 2003,  British  American  Centre,  Phase 3, Dr. Roy's Drive,
          George Town, Grand Cayman.

     (c)  Dr.  Rosenwald  is an  investment  banker,  venture  capitalist,  fund
          manager and sole  shareholder of Paramount  Capital,/1/ a Subchapter S
          corporation  incorporated in the State of Delaware.  Paramount Capital
          is the General  Partner of Aries  Domestic,/2/  a limited  partnership
          incorporated in Delaware.  Paramount Capital is the Investment Manager
          to Aries Trust,/3/ a Cayman Islands Trust.

     (d)  The  Reporting  Parties  and  their  respective  officers,  directors,
          general partners,  investment  managers,  or trustees have not, during
          the five years prior to the date hereof,  been convicted in a criminal
          proceeding (excluding traffic violations or similar misdemeanors).

     (e)  The  Reporting  Parties  and  their  respective  officers,  directors,
          general  partners,  investment  managers,  or trustees  have not been,
          during the five  years  prior to the date  hereof,  parties to a civil
          proceeding  of  a  judicial  or   administrative   body  of  competent
          jurisdiction.

- --------------  
     /1/  Please see attached  Exhibit B indicating  the executive  officers and
          directors of Paramount Capital and providing information called for by
          Items 2-6 of this statement as to said officers and directors. Exhibit
          B is herein incorporated by reference.
 

     /2/  Please see attached  Exhibit C indicating the general partner of Aries
          Domestic and the general  partner's  executive  officers and directors
          and providing information called for by Items 2-6 of this statement as
          to said general partners, officers and directors.  Exhibit C is herein
          incorporated by reference.

     /3/  Please see attached Exhibit D indicating the investment manager of the
          Aries Trust and the investment  manager's executive officers and direc
          tors  and  providing  information  called  for by  Items  2-6 of  this
          statement as to said  investment  manager and officers and  directors.
          Exhibit D is herein incorporated by reference.


                                        7

<PAGE>

          as a result of which such  person  was or is  subject  to a  judgment,
          decree or final order enjoining  future  violations of, or prohibiting
          or mandating  activities  subject to, Federal or State securities laws
          or finding any violation with respect to such laws.

     (f)  Dr. Rosenwald is a citizen of the United States.

Item 3. Source and Amount of Funds or Other Consideration.

          As previously reported in the original statement on Schedule 13-D (the
          "Original  Statement")  filed by the Reporting Parties on November 15,
          1996, in connection  with their initial  acquisition  of shares of the
          Issuer,  Aries  Domestic used its general funds to effect the purchase
          of 292,000  shares of the Issuer in various  open market  transactions
          for an  approximate  aggregate  purchase  price of $407,258  and Aries
          Trust used its general funds to effect its initial purchase of 658,000
          shares for an approximate  aggregate purchase price of $916,692. As of
          the date of the last filing of a Schedule  13D  Amendment  ("Amendment
          No. 5"),  Aries  Domestic  beneficially  owned  622,000  shares of the
          Issuer and the Aries Trust  beneficially owned 1,317,700 shares of the
          Issuer.  Since the date of Amendment  No. 5, Aries  Domestic  used its
          general  funds to effect  the  purchase  of the an  additional  56,600
          shares of common stock of Issuer in various  open market  transactions
          as further set forth in Item 5 for an approximate  aggregate  purchase
          price of $69,878.  Since the date of Amendment No. 5, Aries Trust used
          its general funds to effect the purchase of the an additional  116,800
          shares of common stock of Issuer in various  open market  transactions
          as further set forth in Item 5 for an approximate  aggregate  purchase
          price of $125,971.

Item 4. Purpose of Transaction.

          The  Reporting  Parties  have  acquired  shares of Common Stock of the
          Issuer as an investment in the Issuer.

          Although the  Reporting  Parties have not  formulated  any  definitive
          plans, they may from time to time acquire, or dispose of, Common Stock
          and/or  other  securities  of the  Issuer  if and  when  they  deem it
          appropriate. The Reporting Parties may formulate other purposes, plans
          or proposals  relating to any of such  securities of the Issuer to the
          extent  deemed  advisable  in light of market  conditions,  investment
          policies and other factors.

          Except as  indicated  in this  Schedule  13D,  the  Reporting  Parties
          currently have no plans or proposals that relate to or would result in
          any of the matters  described in subparagraphs (a) through (j) of Item
          4 of Schedule 13D.

Item 5. Interest in Securities of the Issuer.

          (a)  As of June 27, 1997, Dr. Rosenwald and Paramount Capital, through
               acquisi tion of the shares by the Aries Trust and Aries Domestic,
               beneficially  owned  2,112,700  shares  or 13.1% of the  Issuer's
               securities  and Aries  Domestic and the Aries Trust  beneficially
               owned as follows:

                                                           Amount Owned
               Aries Domestic                             678,600 shares
               Aries Trust                              1,434,100 shares

          (b)  Dr. Rosenwald and Paramount Capital share the power to vote or to
               direct the vote, to dispose or to direct the disposition of those
               shares owned by each of Aries Domestic and Aries Trust.

          (c)  The following  purchases  were made by Aries Domestic in the open
               market since the filing of Amendment No. 5:


                                        8

<PAGE>



               Date                No. of Shares              Purchase Price
               ----                -------------              --------------
               4/18/97                   3,500                1.250
               4/21/97                   2,400                1.125
               4/22/97                     500                1.188
               4/24/97                   1,700                1.188
               4/25/97                   3,500                1.313
               4/30/97                   8,500                1.239
               4/30/97                   8,500                1.150
               5/02/97                   3,500                1.250
               5/07/97                   3,500                1.125
               5/13/97                   6,500                1.250
               5/30/97                   5,000                1.125
               6/02/97                   3,500                1.188
               6/03/97                   3,500                1.250
               6/24/97                   3,500                1.219

               The following  purchases  were made by Aries Trust in
               the open market in the since the filing of  Amendment
               No. 5:

               Date                 No. of Shares              Market Price
               ----                 -------------              ------------
               4/18/97                    6,500                1.250
               4/21/97                    4,000                1.125
               4/22/97                    1,000                1.188
               4/24/97                    3,300                1.188
               4/25/97                    6,500                1.313
               4/30/97                   16,500                1.239
               4/30/97                   16,500                1.150
               5/02/97                    6,500                1.250
               5/07/97                    6,500                1.125
               5/13/97                   13,500                1.250
               5/30/97                   10,000                1.125
               6/02/97                    6,500                1.188
               6/03/97                    6,500                1.250
               6/24/97                    6,500                1.219

               Other than as set forth herein the Reporting  Parties
               have not  engaged in any  transactions  in the Common
               Stock of the Issuer during the past 60 days.

          (d)  & (e) Not applicable.


Item 6. Contracts, Arrangements, Understandings or Relationships with respect to
        Securities of the Issuer

          Paramount Capital is the investment manager of the Aries Trust and the
          General  Partner  of Aries  Domestic  and in such  capacities  has the
          authority  to make  certain  investment  decisions  on  behalf of such
          entities,  including  decisions  relating  to  the  securities  of the
          Issuer. In connection with its investment management duties, Paramount
          Capital receives certain  management fees and performance  allocations
          from the Aries Trust and Aries  Domestic.  Dr.  Rosenwald  is the sole
          shareholder of Paramount Capital.  Except as indicated in this 13D and
          exhibits,  there  is  no  contract,   arrangement,   understanding  or
          relationship  between  the  Reporting  Parties  and any other party or
          parties, with respect to any securities of the Issuer.


                                        9

<PAGE>

Item 7. Material to be Filed as Exhibits:

Exhibit A -    Copy of an Agreement  between Dr. Rosenwald,  Paramount  Capital,
               Aries Domestic and Aries Trust to file this Statement on Schedule
               13D on behalf of each of them.

Exhibit B -    List of executive officers and directors of Paramount Capital and
               information called for by Items 2-6 of this statement relating to
               said officers and direc tors.

Exhibit C -    List of executive  officers and  directors of Aries  Domestic and
               information called for by Items 2-6 of this statement relating to
               said officers and direc tors.

Exhibit D -    List of  executive  officers  and  directors  of Aries  Trust and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

                                       10

<PAGE>

                                   SIGNATURES


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    President


                                ARIES DOMESTIC FUND, L.P.
                                By: Paramount Capital Asset Management, Inc.
                                    General Partner

Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    President


                                THE ARIES TRUST
                                By: Paramount Capital Asset Management, Inc.
                                    Investment Manager

Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.


                                       11

<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



         The  undersigned   hereby  agree  to  jointly  prepare  and  file  with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each of the  undersig  ned's  ownership  of  securities  of  Repligen
Corporation,  and hereby  affirm that such Schedule 13D is being filed on behalf
of each of the undersigned.

                                PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    President


                                ARIES DOMESTIC FUND, L.P.
                                By: Paramount Capital Asset Management, Inc.
                                    General Partner

Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.
                                    President


                                THE ARIES TRUST
                                By: Paramount Capital Asset Management, Inc.
                                    Investment Manager

Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


Dated:  July 1, 1997
        New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                    ------------------------------
                                    Lindsay A. Rosenwald, M.D.

                                       13

<PAGE>

                                    EXHIBIT B

         The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  44th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                             PRINCIPAL OCCUPATION
         NAME                                   OR EMPLOYMENT
         ----                                   -------------

Lindsay A. Rosenwald, M.D.          Chairman of the Board, President of
                                    Paramount Capital Asset Management, Inc.,
                                    Paramount Capital Investments, LLC and
                                    Paramount Capital, Inc.

Peter Morgan Kash                   Director of Paramount Capital Asset
                                    Management, Inc., Senior Managing Director,
                                    Paramount Capital, Inc.

Dr. Yuichi Iwaki                    Director of Paramount Capital Asset
                                    Management, Inc., Professor, University of
                                    Southern California School of Medicine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons (to the best of Paramount  Capital's  knowledge) has been convicted in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       13

<PAGE>

                                    EXHIBIT C

         The name and principal  occupation or employment of the General Partner
of Aries Domestic,  which is located at 787 Seventh Avenue,  New York, New York,
10019, is as follows:

                                            PRINCIPAL OCCUPATION
         NAME                                  OR EMPLOYMENT
         ----                                  -------------

Paramount Capital Asset Management, Inc.    General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       14

<PAGE>

                                    EXHIBIT D

         The name and principal  occupation or employment,  which in the case of
Paramount Capital Asset Management,  Inc. is located at 787 Seventh Avenue, 44th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                              PRINCIPAL OCCUPATION
         NAME                                    OR EMPLOYMENT
         ----                                    -------------

Paramount Capital Asset Management, Inc.      Investment Manager

MeesPierson (Cayman) Limited                  Trustee
P.O. Box 2003
British American Centre
Phase 3, Dr. Roy's Drive
George Town, Grand Cayman

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       15



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