REPLIGEN CORP
SC 13D/A, 1997-03-13
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                 SCHEDULE 13D
                               (Amendment No.3)

                   Under the Securities Exchange Act of 1934


                             Repligen Corporation
                               (Name of Issuer)


                    Common Stock, par value $.01 per share
                        (Title of Class of Securities)

                                   759916109
                                (CUSIP Number)


                   Paramount Capital Asset Management, Inc.
                        c/o Lindsay A. Rosenwald, M.D.
                              787 Seventh Avenue
                              New York, NY 10019
                                (212) 554-4300

                                with a copy to:

                             David R. Walner, Esq.
                   Paramount Capital Asset Management, Inc.
                              787 Seventh Avenue
                              New York, NY 10019
                                (212) 554-4372
                              
           (Name, Address and Telephone Number of Person Authorized
                    to Receive Notices and Communications)


                                 March 4, 1996
            (Date of Event which Requires Filing of this Statement)




             If the filing person has previously filed a statement on
             Schedule 13G to report the acquisition which is the
             subject of this Statement because of Rule 13d-1(b)(3) or
             (4), check the following:     
                                                               (X)

             Check the following box if a fee is being paid with this
             Statement:
                                                               (X)




                           
      CUSIP NO. [759916109]   13D                    

- ----------------------------------------------------------------------------
      1    NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Paramount Capital Asset Management, Inc.
- ----------------------------------------------------------------------------

      2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP  (a)(X) (b)(X)
- ----------------------------------------------------------------------------
      3    SEC USE ONLY

- ----------------------------------------------------------------------------
      4    SOURCE OF FUNDS*
           OO (see Item 3 below)
- ----------------------------------------------------------------------------

      5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                       (X)
- ----------------------------------------------------------------------------
      6    CITIZENSHIP OR PLACE OF ORGANIZATION
           Delaware
- ----------------------------------------------------------------------------

                             7    SOLE VOTING POWER
                                  None
            NUMBER OF     --------------------------------------------------
              SHARES         8    SHARED VOTING POWER
           BENEFICIALLY           1,594,800
             OWNED BY     --------------------------------------------------
               EACH          9    SOLE DISPOSITIVE POWER
            REPORTING             None
              PERSON      --------------------------------------------------
               WITH          10   SHARED DISPOSITIVE POWER
                                  1,594,800
- ----------------------------------------------------------------------------
      11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           1,594,800
- ----------------------------------------------------------------------------

      12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
           SHARES*
                                                                       (X)
- ---------------------------------------------------------------------------
      13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           10.2%
- ---------------------------------------------------------------------------

      14   TYPE OF REPORTING PERSON*
           CO
- ---------------------------------------------------------------------------


                            
      CUSIP NO. [759916109] 13D      
- ---------------------------------------------------------------------------
      1    NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Aries Domestic Fund, L.P.
- ---------------------------------------------------------------------------

      2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)(X)  b)(X)
- ---------------------------------------------------------------------------
      3    SEC USE ONLY

- ---------------------------------------------------------------------------
      4    SOURCE OF FUNDS*
           OO (see Item 3 below)
- ---------------------------------------------------------------------------
      5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                       (X)
- ---------------------------------------------------------------------------
      6    CITIZENSHIP OR PLACE OF ORGANIZATION
           Delaware
- ---------------------------------------------------------------------------

                             7    SOLE VOTING POWER
                                  None
            NUMBER OF    --------------------------------------------------
              SHARES         8    SHARED VOTING POWER
           BENEFICIALLY           505,500
             OWNED BY    --------------------------------------------------
               EACH          9    SOLE DISPOSITIVE POWER
            REPORTING             None
              PERSON     --------------------------------------------------
               WITH          10   SHARED DISPOSITIVE POWER
                                  505,500
- ---------------------------------------------------------------------------

      11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           505,500

- ---------------------------------------------------------------------------
      12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
           SHARES*
                                                                       (X)
- ---------------------------------------------------------------------------
      13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           3.2%
- ---------------------------------------------------------------------------

      14   TYPE OF REPORTING PERSON*
           PN
- ---------------------------------------------------------------------------


                            
      CUSIP NO. [759916109] 13D   
- ---------------------------------------------------------------------------
      1    NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           The Aries Trust
- ---------------------------------------------------------------------------
      2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP  (a)(X) (b)(X) 

- ---------------------------------------------------------------------------
      3    SEC USE ONLY

- ---------------------------------------------------------------------------
      4    SOURCE OF FUNDS*
           OO (see Item 3 below)
- ---------------------------------------------------------------------------
      5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
           PURSUANT TO
           ITEM 2(d) or 2(e)
                                                                       (X)
- ---------------------------------------------------------------------------
      6    CITIZENSHIP OR PLACE OF ORGANIZATION
           Cayman Islands
- ---------------------------------------------------------------------------

                             7    SOLE VOTING POWER
                                  None
            NUMBER OF     -------------------------------------------------
              SHARES         8    SHARED VOTING POWER
           BENEFICIALLY           1,104,300
             OWNED BY     -------------------------------------------------
               EACH          9    SOLE DISPOSITIVE POWER
            REPORTING             None
              PERSON      -------------------------------------------------
               WITH          10   SHARED DISPOSITIVE POWER
                                  1,104,300
- ---------------------------------------------------------------------------

      11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           1,104,300
- ---------------------------------------------------------------------------
      12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
           SHARES*
                                                                       (X)
- ---------------------------------------------------------------------------
      13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           7.0%
- ---------------------------------------------------------------------------
      14   TYPE OF REPORTING PERSON*
           OO (see Item 2)
- ---------------------------------------------------------------------------



                            
      CUSIP NO. [759916109] 13D    
- ---------------------------------------------------------------------------
      1    NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Lindsay A. Rosenwald, M.D.
- ---------------------------------------------------------------------------
      2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)(X)  (b)(X) 

- ---------------------------------------------------------------------------
      3    SEC USE ONLY

- ---------------------------------------------------------------------------
      4    SOURCE OF FUNDS*
           OO (see Item 3 below)
- ---------------------------------------------------------------------------
      5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                       (X)
- ---------------------------------------------------------------------------
      6    CITIZENSHIP OR PLACE OF ORGANIZATION
           United States
- ---------------------------------------------------------------------------

                             7    SOLE VOTING POWER
                                  None
            NUMBER OF     -------------------------------------------------
              SHARES         8    SHARED VOTING POWER
           BENEFICIALLY           1,594,800
             OWNED BY     -------------------------------------------------
               EACH          9    SOLE DISPOSITIVE POWER
            REPORTING             None
              PERSON      -------------------------------------------------
               WITH          10   SHARED DISPOSITIVE POWER
                                  1,594,800
- ---------------------------------------------------------------------------
      11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           1,594,800

- ---------------------------------------------------------------------------
      12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN
           SHARES*
                                                                       (X)
- ---------------------------------------------------------------------------
      13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           10.2%

- ---------------------------------------------------------------------------
      14   TYPE OF REPORTING PERSON*
           IN
- ---------------------------------------------------------------------------



     Item 1.   Security and Issuer.

          (a)  Common Stock, $.01 par value ("Shares")

               Repligen Corporation
               117 Fourth Avenue
               Needham, MA 02194
               617-449-9560

     Item 2.   Identity and Background.

          Names of Persons Filing:

          (a)  This statement is filed on behalf of Paramount Capital Asset
               Management, Inc. ("Paramount Capital"), Aries Domestic Fund,
               L.P. ("Aries Domestic"), The Aries Trust ("Aries Trust") and
               Lindsay A. Rosenwald, M.D. ( Dr. Rpsenwald and collectively
               with Paramount Capital, Aries Domestic and Aries Truat, the
               "Reporting Parties"). See attached Exhibit A which is a copy
               of their agreement in writing to file this statement on
               behalf of each of them.

          (b)  The business address of Paramount Capital, Aries Domestic
               and Dr. Rosenwald is 787 Seventh Avenue, New York, New York,
               10019. The business address for Aries Trust is c/o
               MeesPierson (Cayman) Limited, P.O. Box 2003, British
               American Centre, Phase 3, Dr. Roy's Drive, George Town,
               Grand Cayman.

          (c)  Dr. Rosenwald is an investment banker, venture capitalist,
               fund manager and sole shareholder of Paramount Capital,(1) a
               Subchapter S corporation incorporated in the State of
               Delaware. Paramount Capital is the General Partner of Aries
               Domestic,(2) a limited partnership incorporated in Delaware.
               Paramount Capital is the Investment Manager to Aries Trust,(3)
               a Cayman Islands Trust.

          (d)  The Reporting Parties and their respective officers,
               directors, general partners, investment managers, or
               trustees have not, during the five years prior to the date
               hereof, been convicted in a criminal proceeding (excluding
               traffic violations or similar misdemeanors).

          (e)  The Reporting Parties and their respective officers,
               directors, general partners, investment managers, or
               trustees have not been, during the five years prior to the
               date hereof, parties to a civil proceeding of a judicial or
               administrative body of competent juris diction, as a result
               of which such person was or is subject to a judgment, decree
               or final order enjoining future violations of, or
               prohibiting or mandating activities subject to, Federal or
               State securities laws or finding any violation with respect
               to such laws.

          (f)  Dr. Rosenwald is a citizen of the United States.

       ----------------------------

        1      Please see attached Exhibit B indicating the executive
               officers and directors of Paramount Capital and providing
               information called for by Items 2-6 of this statement as to
               said officers and directors.  Exhibit B is herein
               incorporated by reference.

        2      Please see attached Exhibit C indicating the general partner
               of Aries Domestic and the general partner's executive
               officers and directors and providing information called for
               by Items 2-6 of this statement as to said general partners,
               officers and directors. Exhibit C is herein incorporated by
               reference.

        3      Please see attached Exhibit D indicating the investment
               manager of the Aries Trust and the investment manager's
               executive officers and directors and providing information
               called for by Items 2-6 of this statement as to said
               investment manager and officers and directors. Exhibit D is
               herein incorporated by reference.


     Item 3.   Source and Amount of Funds or Other Consideration.

               As previously reported in the original statement on Schedule
               13-D (the "Original Statement") filed by the Reporting
               Parties on November 15, 1996, in connection with their
               initial acquisition of shares of the Issuer, Aries Domestic
               used its general funds to effect the purchase of 292,000
               shares of the Issuer in various open market transactions for
               an approximate aggregate purchase price of $407,258 and
               Aries Trust used its general funds to effect its initial
               purchase of 658,000 shares for an approximate aggregate
               purchase price of $916,692. Since the date of the Original
               Statement, Aries Domestic used its general funds to effect
               the purchase of an additional 69,700 shares of the Issuer in
               various open market transactions for an approximate
               aggregate purchase price of $88,093 and the Aries Trust has
               used its general funds to effect the purchase of an
               additional 164,700 shares of the Issuer in various open
               market transactions for an approximate aggregate purchase
               price of $208,215 ( Amendment No. 1 ). Since the date of
               Amendment No. 1, the Aries Domestic used its general funds
               to effect the purchase of an additional 87,800 shares of the
               Issuer and the Aries Trust has used its general funds to
               effect the purchase of an additional 167,600 shares of the
               Issuer in various open market transactions ( Amendment No.
               2"). Since the date of Amendment No. 2, the Aries Domestic
               and the Aries Trust have also used their general funds to
               effect certain purchases of the securities of Issuer in open
               market transactions including purchase occurring since the
               date of Amendment No. 2 as further set forth in Item 5.

     Item 4.   Purpose of Transaction.

               The Reporting Parties have acquired shares of Common Stock
               of the Issuer as an investment in the Issuer.

               Although the Reporting Parties have not formulated any
               definitive plans, they may from time to time acquire, or
               dispose of, Common Stock and/or other securities of the
               Issuer if and when they deem it appropriate. The Reporting
               Parties may formulate other purposes, plans or proposals
               relating to any of such securities of the Issuer to the
               extent deemed advisable in light of market conditions,
               investment policies and other factors.

               Except as indicated in this Schedule 13D, the Reporting
               Parties currently have no plans or proposals that relate to
               or would result in any of the matters described in
               subparagraphs (a) through (j) of Item 4 of Schedule 13D.

     Item 5.   Interest in Securities of the Issuer.

               (a)  As of March 6, 1997, Dr. Rosenwald and Paramount
                    Capital, through acquisition of the shares by the Aries
                    Trust and Aries Domestic, beneficially owned 1,594,800
                    shares or 10.2% of the Issuer's securities and Aries
                    Domestic and the Aries Trust beneficially owned as
                    follows:

                                                      Amount Owned
                                                      ------------
                    Aries Domestic                   505,500 shares
                    Aries Trust                    1,104,300 shares

               (b)  Dr. Rosenwald and Paramount Capital share the power
                    to vote or to direct the vote, to dispose or to direct
                    the disposition of those shares owned by each of Aries
                    Domestic and Aries Trust.

               (c)  The following purchases were made by Aries Domestic
                    in the open market since the filing of Amendment No. 2:

                    Date           No. of Shares       Purchase Price
                    ----           -------------       --------------
                    2/11/97             13,000              1.250
                    2/13/97              1,500              1.250
                    2/20/97             11,500              1.250
                    2/26/97              10,000             1.250
                    2/27/97              5,000              1.250
                    3/04/97             5,000               1.250
                    3/6/97              5,000               1.250

                    The following purchases were made by Aries Trust in the
                    open market in the since the filing of Amendment No. 2:

                    Date           No. of Shares         Market Price
                    ----           -------------         ------------
                    2/11/97             27,000              1.250
                    2/13/97              3,500              1.250
                    2/20/97             23,500              1.250
                    2/26/97              20,000             1.250
                    2/27/97             10,000              1.250
                    3/04/97             10,000              1.250
                    3/6/97              10,000              1.250

                    Other than as set forth herein the Reporting Parties
                    have not engaged in any transactions in the Common
                    Stock of the Issuer during the past 60 days.

               (d) & (e) Not applicable.


     Item 6.   Contracts, Arrangements, Understandings or Relationships
               with respect to Securities of the Issuer                

               Paramount Capital is the investment manager of the Aries
               Trust and the General Partner of Aries Domestic and in such
               capacities has the authority to make certain investment
               decisions on behalf of such entities, including decisions
               relating to the securities of the Issuer. In connection with
               its investment management duties, Paramount Capital receives
               certain management fees and performance allocations from the
               Aries Trust and Aries Domestic. Dr. Rosenwald is the sole
               shareholder of Paramount Capital. Except as indicated in
               this 13D and exhibits, there is no contract, arrangement,
               understanding or relationship between the Reporting Parties
               and any other party or parties, with respect to any
               securities of the Issuer.


     Item 7.   Material to be Filed as Exhibits:

     Exhibit A - Copy of an Agreement between Dr. Rosenwald, Paramount
                 Capital, Aries Domestic and Aries Trust to file this
                 Statement on Schedule 13D on behalf of each of them.

     Exhibit B - List of executive officers and directors of Paramount
                 Capital and information called for by Items 2-6 of this
                 statement relating to said officers and directors.

     Exhibit C - List of executive officers and directors of Aries
                 Domestic and information called for by Items 2-6 of this
                 statement relating to said officers and directors.

     Exhibit D - List of executive officers and directors of Aries
                 Trust and information called for by Items 2-6 of this
                 statement relating to said officers and directors.



                                 SIGNATURES

               After reasonable inquiry and to the best of my knowledge and
     belief, I certify that the information set forth in this statement is
     true, complete and correct.


                                       PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                          Lindsay A. Rosenwald, M.D.
                                          President


                                       ARIES DOMESTIC FUND, L.P.
                                       By: Paramount Capital Asset
                                             Management, Inc.
                                           General Partner

     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                          Lindsay A. Rosenwald, M.D.
                                          President


                                       THE ARIES TRUST
                                       By: Paramount Capital Asset
                                             Management, Inc.
                                           Investment Manager

     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                          Lindsay A. Rosenwald, M.D.
                                          President


     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald, M.D. 
                                           Lindsay A. Rosenwald, M.D.


                                 EXHIBIT A

                                 AGREEMENT

                        JOINT FILING OF SCHEDULE 13D

               The undersigned hereby agree to jointly prepare and file with
     regulatory authorities a Schedule 13D and any future amendments thereto
     reporting each of the undersigned's ownership of securities of Repligen
     Corporation, and hereby affirm that such Schedule 13D is being filed on
     behalf of each of the undersigned.


                                      PARAMOUNT CAPITAL ASSET 
                                        MANAGEMENT, INC.

     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald. M.D.  
                                          Lindsay A. Rosenwald, M.D.
                                          President


                                       ARIES DOMESTIC FUND, L.P.
                                       By: Paramount Capital Asset
                                             Management, Inc.
                                           General Partner

     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                          Lindsay A. Rosenwald, M.D.
                                          President


                                       THE ARIES TRUST
                                       By: Paramount Capital Asset
                                             Management, Inc.
                                           Investment Manager

     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.
                                          Lindsay A. Rosenwald, M.D.
                                          President

     Dated:    March 6, 1997
               New York, NY            By: /s/ Lindsay A. Rosenwald, M.D.  
                                           Lindsay A. Rosenwald, M.D.



                                 EXHIBIT B

          The name and principal occupation or employment, which in each
     instance is with Paramount Capital Asset Management, Inc. ("Paramount
     Capital") located at 787 Seventh Avenue, 44th Floor, New York, New
     York, 10019, of each executive officer and director of Paramount
     Capital is as follows:

                                                  PRINCIPAL OCCUPATION
          NAME                                       OR EMPLOYMENT

     Lindsay A. Rosenwald, M.D.           Chairman of the Board, President
                                          of Paramount Capital Asset
                                          Management, Inc., Paramount
                                          Capital Investments, LLC and
                                          Paramount Capital, Inc.

     Peter Morgan Kash                    Director of Paramount Capital
                                          Asset Management, Inc., Senior
                                          Managing Director, Paramount
                                          Capital, Inc.

     Dr. Yuichi Iwaki                     Director of Paramount Capital
                                          Asset Management, Inc.,
                                          Professor, University of
                                          Southern California School of
                                          Medicine


     Item 2.

          During the five years prior to the date hereof, none of the above
     persons (to the best of Paramount Capital s knowledge) has been
     convicted in a criminal proceeding (excluding traffic violations or
     similar misdemeanors) or was a party to a civil proceeding of a
     judicial or administrative body of competent jurisdiction, as a result
     of which such person was or is subject to a judgment, decree or final
     order enjoining future violations of, or prohibiting or mandating
     activities subject to, Federal or State securities laws or finding any
     violation with respect to such laws.

     Items 3-6.

          Please refer to Items 3-6 herein reporting the beneficial ownership.



                                 EXHIBIT C

          The name and principal occupation or employment of the General
     Partner of Aries Domestic, which is located at 787 Seventh Avenue, New
     York, New York, 10019, is as follows:

                                                  PRINCIPAL OCCUPATION
          NAME                                       OR EMPLOYMENT

     Paramount Capital Asset Management, Inc.     General Partner;
     Investment Manager

          Exhibit B is hereby incorporated by reference.

     Item 2.

          During the five years prior to the date hereof, the above person
     (to the best of Aries Domestic's knowledge) has not been convicted in
     a criminal proceeding (excluding traffic violations or similar
     misdemeanors) or was a party to a civil proceeding of a judicial or
     administrative body of competent jurisdiction, as a result of which
     such person was or is subject to a judgment, decree or final order
     enjoining future violations of, or prohibiting or mandating activities
     subject to, Federal or State securities laws or finding any violation
     with respect to such laws.

     Items 3-6.

          Please refer to Items 3-6 herein reporting the beneficial ownership.



                                 EXHIBIT D

          The name and principal occupation or employment, which in the
     case of Paramount Capital Asset Management, Inc. is located at 787
     Seventh Avenue, 44th Floor, New York, New York, 10019, of each
     executive officer and director of Aries Trust is as follows:

                                                  PRINCIPAL OCCUPATION
          NAME                                       OR EMPLOYMENT

     Paramount Capital Asset Management, Inc.     Investment Manager

     MeesPierson (Cayman) Limited                 Trustee
     P.O. Box 2003
     British American Centre
     Phase 3, Dr. Roy s Drive
     George Town, Grand Cayman 

          Exhibit B is hereby incorporated by reference.

     Item 2.

          During the five years prior to the date hereof, neither of the
     above persons (to the best of Aries Trust's knowledge) have been
     convicted in a criminal proceeding (excluding traffic violations or
     similar misdemeanors) or was a party to a civil proceeding of a
     judicial or administrative body of competent jurisdiction, as a result
     of which such person was or is subject to a judgment, decree or final
     order enjoining future violations of, or prohibiting or mandating
     activities subject to, Federal or State securities laws or finding any
     violation with respect to such laws.

     Items 3-6.

          Please refer to Items 3-6 herein reporting the beneficial ownership.



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