REPLIGEN CORP
DEF 14A, 1997-06-17
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION

                Proxy Statement Pursuant to Section 14(a) of the
                Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ] Preliminary Proxy Statement       [X] Confidential, for Use of the
                                          Commission Only (as permitted by
                                          Rule 14a-6(e)(2))
[X] Definitive Proxy Statement

[ ] Definitive Additional Materials

[ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                             Repligen Corporation
                             --------------------
                (Name of Registrant as Specified in Its Charter)

- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of filing fee (Check the appropriate box):

[X]  No fee required.
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

       (1)  Title of each class of securities to which transaction applies:
              not applicable
              --------------

       (2)  Aggregate number of securities to which transaction applies:
              not applicable
              --------------
       (3)  Per unit price or other underlying value of transaction computed
            pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
            the filing fee is calculated and state how it was determined):
              not applicable
              --------------
       (4)  Proposed maximum aggregate value of transaction:
              not applicable
              --------------
       (5)  Total fee paid:
              not applicable
              --------------

[ ]  Fee paid previously with preliminary materials:
[ ]  Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously. Identify the previous filing by registration
     statement number, or the Form or Schedule and the date of its filing.

     (1)  Amount Previously Paid:
             not applicable
             --------------
     (2)  Form, Schedule or Registration Statement No.:
             not applicable
             --------------
     (3)  Filing Party:
             not applicable
             --------------
     (4)  Date Filed:
             not applicable
             --------------
<PAGE>

                              Repligen Corporation

                                117 Fourth Avenue
                                Needham, MA 02194
                                 (617-449-9560)

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JULY 24, 1997



To the Stockholders:


         The Annual Meeting of Stockholders of Repligen Corporation, a Delaware
Corporation (the "Company"), will be held on Thursday, July 24, 1997, 10:00 a.m.
local time, at the offices of the Company, 117 Fourth Avenue, Needham,
Massachusetts to consider and act upon the following matters:

      1.       To elect four members to the Board of Directors to serve a
               one-year term and until their successors are duly elected and
               qualified.

      2.       To consider and act upon a proposal to ratify the selection of
               Arthur Andersen LLP as the independent auditors of the Company
               for the fiscal year ending March 31, 1998.

      3.       To transact such other business as may properly come before the
               Annual Meeting or any adjournments thereof.

         The Board of Directors has fixed the close of business on June 9, 1997
as the record date for determining the stockholders entitled to notice of and to
vote at the Annual Meeting. A list of stockholders entitled to vote at the
Annual Meeting will be open to examination by stockholders during ordinary
business hours for a period of ten (10) days prior to the Annual Meeting at the
offices of the Company set forth above. The list will also be available at the
Annual Meeting.
         All stockholders are cordially invited to attend the Annual Meeting in
person. To ensure your representation at the meeting, however, you are urged to
complete, sign, date and return the enclosed proxy card as promptly as possible
in the enclosed postage-paid envelope. You may revoke your proxy in the manner
described in the accompanying Proxy Statement at any time before it has been
voted at the Annual Meeting. Any stockholder attending the Annual Meeting may
vote in person even if such stockholder has returned a proxy.


                                       By Order of the Board of Directors




                                       Daniel P. Witt, Secretary
Needham, Massachusetts
June 19, 1997




<PAGE>



- --------------------------------------------------------------------------------
IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED AT THE MEETING. WHETHER OR NOT
YOU PLAN TO ATTEND THE MEETING IN PERSON, YOU ARE REQUESTED TO COMPLETE, SIGN,
DATE AND MAIL PROMPTLY THE ENCLOSED PROXY WHICH IS BEING SOLICITED ON BEHALF OF
THE BOARD OF DIRECTORS. A RETURN ENVELOPE WHICH REQUIRES NO POSTAGE IF MAILED IN
THE UNITED STATES IS ENCLOSED FOR THAT PURPOSE.
- --------------------------------------------------------------------------------


<PAGE>


                              REPLIGEN CORPORATION
                                117 FOURTH AVENUE
                                NEEDHAM, MA 02194

                                 PROXY STATEMENT

                     FOR THE ANNUAL MEETING OF STOCKHOLDERS

                            TO BE HELD JULY 24, 1997


         This Proxy Statement is furnished in connection with the solicitation
by and on behalf of the Board of Directors (the "Board") of Repligen
Corporation, a Delaware corporation ("Repligen" or the "Company"), of proxies to
be voted at the Annual Meeting of Stockholders of the Company to be held,
pursuant to the accompanying Notice of Annual Meeting, on Thursday, July 24,
1997, and at any adjournments thereof (the "Annual Meeting" or the "Meeting").
Only stockholders of record as of June 9, 1997 (the "Record Date") will be
entitled to notice of and to vote at the Meeting and any adjournments thereof.
As of the Record Date, 16,001,785 shares of Common Stock, $.01 par value (the
"Common Stock"), of the Company were issued and outstanding.

         The holders of Common Stock are entitled to one vote per share on any
proposal presented at the Annual Meeting. Stockholders may vote in person or by
proxy. Execution of a proxy will not in any way affect a stockholder's right to
attend the Annual Meeting and vote in person. Any proxy given pursuant to this
solicitation may be revoked by the person giving it any time before it is voted.
Proxies may be revoked by the person giving it any time before it is voted.
Proxies may be revoked by: (1) filing with the Secretary of the Company, before
the taking of the vote at the Annual Meeting, a written notice of revocation
bearing a later date than the proxy; (2) duly executing a later-dated proxy
relating to the same shares and delivering it to the Secretary of the Company
before the taking of the vote at the Annual Meeting; or (3) attending the Annual
Meeting and voting in person (although attendance at the Annual Meeting will not
in and of itself constitute a revocation of a proxy). Any written notice of
revocation or subsequent proxy should be sent so as to be delivered to Repligen
Corporation, 117 Fourth Avenue, Needham, Massachusetts 02194, Attention:
Secretary, at or before the taking of the vote at the Annual Meeting.

         The persons named as attorneys in the proxies are directors and/or
officers of the Company. All properly-executed proxies returned in time to be
counted at the Annual Meeting will be voted as stated below under the heading
"Voting Procedures." Any stockholder submitting a proxy has the right to
withhold authority to vote for any individual nominee to the Board of Directors
by writing that nominee's name on the space provided on the proxy. In addition
to the election of Directors, the stockholders will consider and vote upon a
proposal to ratify the selection of auditors, as further described in this Proxy
Statement. Where a choice has been specified on the proxy with respect to a
matter, the shares represented by the proxy will be voted in accordance with the
specifications and will be voted FOR if no specification is indicated.

         The representation in person or by proxy of at least a majority of the
outstanding shares of Common Stock entitled to vote at the Annual Meeting is
necessary to establish a quorum for the transaction of business. Votes withheld
from any nominee, abstentions, and broker "non-votes" are counted as present or
represented for purposes of determining the presence or absence of a quorum. A
"non-vote" occurs when a broker holding shares for a beneficial 


                                       1
<PAGE>

owner votes on one proposal but does not vote on another proposal because,
with respect to such other proposals, the broker does not have discretionary
voting power and has not received instructions from the beneficial owner.
Directors are elected by a plurality of the votes cast by stockholders entitled
to vote at the Meeting. All other matters being submitted require the
affirmative vote of the majority of shares present in person or represented by
proxy at the Annual Meeting. An automated system administered by the Company's
transfer agent tabulates the votes. The vote on each matter submitted to
stockholders is tabulated separately. Abstentions are included in the number of
shares present or represented and voting on each matter and, therefore, with
respect to votes on specific proposals, will have the effect of negative votes.
Broker "non-votes" are not so included.

         The Board of Directors knows of no other matters to be presented at the
Annual Meeting. If any other matter should be presented at the Annual Meeting
upon which a vote properly may be taken, shares represented by all proxies
received by the Company will be voted with respect thereto in accordance with
the judgment of the persons named as attorneys in the proxies.

         The Company's Annual Report, containing financial statements and
Management's Discussions and Analysis of Financial Condition and Results of
Operations for the fiscal year ended March 31, 1997, is being mailed
contemporaneously with this Proxy Statement to all stockholders entitled to
vote. This Proxy Statement and the form of proxy were first mailed to
stockholders of record on or about the date hereof.

         The Company's principal executive offices are located at 117 Fourth
Avenue, Needham, Massachusetts 02194. The Company intends to mail this Proxy
Statement and related form of Proxy on or about June 19, 1997 to its
stockholders of record at the close of business on June 9, 1997.


                                       2
<PAGE>



                 OCCUPATIONS OF DIRECTORS AND EXECUTIVE OFFICERS

         The following table sets forth the directors and executive officers of
the Company, their ages and present positions with the Company as of the date of
the Record Date:

<TABLE>
<CAPTION>
      Name                                Age                       Positions
      ----                                ---                       ---------
<S>                                       <C>      <C>
Walter C. Herlihy, Ph.D. ..               45       President, Chief Executive Officer and Director (3)
James R. Rusche, Ph.D......               43       Vice President, Research and Development
Daniel P. Witt, Ph.D.......               49       Vice President, Business Development
G. William Miller..........               72       Director (1) (2) (3)
Alexander Rich, M.D........               72       Director (2)
Paul Schimmel, Ph.D........               56       Director (1) (3)
</TABLE>
- ------------------------------------
(1) Member of the Compensation Committee
(2) Member of the Audit Committee
(3) Member of the Executive Committee

                            BIOGRAPHICAL INFORMATION

Walter C. Herlihy, Ph.D. joined the Company in March 1996 as President, Chief
Executive Officer and Director in connection with the Company's merger with
Glycan Pharmaceuticals, Inc. From July 1993 to March 1996, Dr. Herlihy was the
President and CEO of Glycan Pharmaceuticals, Inc. From October 1981 to June
1993, he held numerous research positions at Repligen, most recently as Senior
Vice President, Research and Development. Dr. Herlihy holds an A.B. degree in
chemistry from Cornell University and a Ph.D. in chemistry from MIT.

James R. Rusche, Ph.D. joined the Company in March 1996 as Vice President,
Research and Development in connection with the Company's merger with Glycan
Pharmaceuticals, Inc. From July 1994 to March 1996, Dr. Rusche was Vice
President, Research and Development of Glycan Pharmaceuticals, Inc. From
February 1985 to June 1994, he held numerous research positions at Repligen,
most recently as Vice President, Discovery Research. Dr. Rusche holds a B.S.
degree in microbiology from the University of Wisconsin, LaCrosse and a Ph.D. in
immunology from the University of Florida.

Daniel P. Witt, Ph.D. joined the Company in March 1996 as Vice President,
Business Development in connection with the Company's merger with Glycan
Pharmaceuticals, Inc. From October 1993 to March 1996, Dr. Witt was Vice
President, Business Development of Glycan Pharmaceuticals, Inc. From April 1983
to September 1993, he held numerous research positions at Repligen, most
recently as Vice President, Technology Acquisition. Dr. Witt holds a B.A. degree
in chemistry from Gettysberg College and a Ph.D. in biochemistry from the
University of Vermont.

Alexander Rich, M.D.,Co-Founder and Co-Chairman of the Board of Directors of the
Company, has been on the faculty of MIT since 1958 and is the Sedgwick Professor
of Biophysics. Internationally recognized for his contributions to the molecular
biology of nucleic acids, he has determined their three-dimensional structure
and has investigated 


                                       3
<PAGE>

their activity in biological systems. He is widely known for his work in
elucidating the three-dimensional structure of transfer RNA, which is a
component of the protein synthesizing mechanism and for his discovery of a
novel, left-handed form of DNA. He is a member of the National Academy of
Sciences, the American Philosophical Society, the Pontifical Academy of
Sciences, Rome and a foreign member of the French Academy of Sciences, Paris.
Dr. Rich has been a Director of the Company since March 1981. Dr. Rich is a
director of Bristol-Myers Squibb Corporation and Alkermes, Inc.

Paul Schimmel, Ph.D., Co-Founder and Co-Chairman of the Board of Directors of
the Company, has been on the faculty of MIT since 1967 and is a Professor of
Biochemistry and Biophysics. He is well known for his work in biophysical
chemistry and molecular biology. His field of specialty is the mechanism of
action of proteins and the manner in which they act upon the nucleic acids in
the cell. This work involves broad applications of recombinant DNA technology.
He is a member of the National Academy of Sciences, received the 1978 ACS/Pfizer
award for excellence in enzyme research, and is co-author of a widely read
textbook on biophysical chemistry. He also previously served as the Chairman,
Director of Biological Chemistry, American Chemical Society. Dr. Schimmel has
been a Director of the Company since March 1981. Dr. Schimmel is a director of
Alkermes, Inc. and Cubist Pharmaceuticals, Inc.

G. William Miller has served as a Director of the Company since January 1982.
Mr. Miller is the Chairman of the Board, G. William Miller & Co., Inc., a
private merchant banking firm. He has served in that capacity for over five
years. From January 1990 until February 1992, Mr. Miller was Chairman and Chief
Executive Officer of Federated Stores, Inc., an owner and operator of retail
department stores, supermarkets and real estate interests. Mr. Miller is a
former Chairman of the Board of Governors of the Federal Reserve System and
served as Secretary of the Treasury under President Carter. Mr. Miller is a
director of the Simon DeBartolo Group, Inc., a real estate investment trust,
Kleinwort Benson Australian Income Fund, Inc., and GS Industries, Inc., a
producer of steel and related products.

         No family relationship exists among the officers and directors of the
Company.


         INFORMATION REGARDING THE BOARD OF DIRECTORS AND ITS COMMITTEES

         The Board of Directors met six times during the fiscal year ended March
31, 1997. Each of the incumbent directors attended at least 75% of the aggregate
number of meetings of the Board and the committees of which he was a member held
during the period in which he served on the Board or such committee.

         The Board has a standing Audit Committee, Compensation Committee and
Executive Committee. The Audit Committee, currently consisting of Mr. Miller and
Dr. Rich, is responsible for determining the adequacy of the Company's internal
accounting and financial controls. It met once with management and the Company's
independent public accountants in the fiscal year ended March 31, 1997 to review
matters pertaining to the 1997 fiscal year audit. No member of the Audit
Committee is a member of the Company's management. The Compensation Committee,
currently consisting of Dr. Schimmel and Mr. Miller, is responsible for
reviewing matters pertaining to the compensation of the Company's officers and
the granting of stock options (other than stock options which are automatically
granted to certain members of the Board pursuant to the Company's stock option
plan) and contributions to the Company's Employee Stock


                                       4
<PAGE>



Ownership Plan. See "Compensation of Directors" and "Compensation Committee
Report to Shareholders." It met once during the fiscal year ended March 31,
1997. No member of the Compensation Committee is a member of the Company's
management. The Executive Committee, currently consisting of Mr. Miller, Dr.
Schimmel and Dr. Herlihy (an employee of the Company), is authorized to exercise
certain powers of the Board not specifically reserved to the Board by the
Company's By-Laws or the General Corporation Law of the State of Delaware. The
Board does not have a standing nominating committee.


                        SUMMARY OF EXECUTIVE COMPENSATION

                           Summary Compensation Table

         The following table sets forth certain information with respect to the
annual and long-term compensation for services in all capacities to the Company
for the past three fiscal years of each of (i) the Company's Chief Executive
Officer, and (ii) each of the Company's other most highly compensated executive
officers who earned more than $100,000 in salary and bonus in fiscal 1997 and
were serving as executive officers as of March 31, 1997 (collectively, the
"Named Executive Officers").


<TABLE>
<CAPTION>
                                               Annual                 Other            Long-Term Compensation (2)
                                           Compensation(1)      Annual Compensation
- ---------------------------------------------------------------------------------------------------------------------
                                                                                        Shares
Name and                      Fiscal      Salary        Bonus                         Underlying     All Other
Principle Position             Year        ($)           ($)                          Options (#)    Compensation
- ---------------------------------------------------------------------------------------------------------------------
<S>                            <C>          <C>           <C>            <C>            <C>                <C>
Walter C. Herlihy, Ph.D.       1997         160,000       15,000         --               --               --
President and Chief            1996           6,667           --         --             100,000            --
Executive Officer              1995 *            --           --         --               --               --


James R. Rusche, Ph.D.         1997         115,000       10,000         --               --               --
Vice President,                1996           4,792           --         --             60,000             --
Research and Development       1995 *            --           --         --               --               --

Daniel P. Witt,                1997         115,000       10,000         --               --               --
Ph.D.                          1996           4,792           --         --             60,000             --
Vice President, Business       1995 *            --           --         --               --               --
Development
</TABLE>

         * Was not employed by Repligen during fiscal 1995.

(1)      The aggregate amount of perquisites and other personal benefits for
         each of the Named Executive Officers did not exceed the lesser of
         either $50,000 or 10% of such individual's base salary and bonus, as
         reported herein, for the applicable fiscal years, and is not reflected
         in the table.


                                       5
<PAGE>

(2)      Represents stock options granted during the fiscal years ended March
         31, 1997, 1996 or 1995. The Company did not grant any restricted stock
         awards or stock appreciation rights or make any long-term incentive
         plan payouts during the fiscal years ended March 31, 1997, 1996 or
         1995.

Option Grants in Last Fiscal Year

The following table sets forth certain information regarding individual grants
of stock options to purchase shares of Common Stock made to the Named Executive
Officers during the fiscal year ending March 31, 1997.



<TABLE>
<CAPTION>
                                       OPTIONS/SARs GRANTED IN LAST FISCAL YEAR
- ---------------------------------------------------------------------------------------------------------------------
                                                                                                      Potential     
                                                   Percent of                                      Realizable Value 
                                                      Total                                       at Assumed Annual 
                                                    Options/                                        Rates of Stock  
                                       Options/   SARs Granted                                          Price       
                                        SASRs     to Employees    Exercise or                      Appreciation for 
                                       Granted      in Fiscal     Base Price      Expiration      Option Term ($)(1)
Name                                     (#)          Year         ($/Share)          Date          5%       10%    
- ---------------------------------------------------------------------------------------------------------------------
<S>                                      <C>           <C>            <C>              <C>          <C>      <C>   
Walter C. Herlihy, Ph.D.(2)              --            --             --               --           --       --

James R. Rusche, Ph.D. (2)               --            --             --               --           --       --

Daniel P. Witt, Ph.D. (2)                --            --             --               --           --       --
</TABLE>


(1) Amounts represent hypothetical gains that could be achieved from the
exercise of respective options and the subsequent sale of the Common Stock
underlying such options if the options were exercised immediately prior to the
end of the option term. These gains are based on assumed rates of stock price
appreciation of 5% and 10% compounded annually from the date the respective
options were granted. These rates of appreciation are mandated by the rules of
the Securities and Exchange Commission and do not represent the Company's
estimate or projection of the future Common Stock price.

(2) There were no stock option grants to Named Executive Officers during the
fiscal year ending March 31, 1997.


                                       6
<PAGE>


<TABLE>
Aggregated Option Exercises In Last Fiscal Year And Fiscal Year-End Option Values
                                                                                   
<CAPTION>
                                                                                               Value of    
                                                           Number of Options at    Unexercised In-the-Money
                               Shares                         Fiscal Year-End          Options at Fiscal   
                            Acquired on        Value           Exercisable/          Year-End Exercisable/ 
Name                        Exercise (1)    Realized($)      Unexercisable (2)         Unexercisable (3)   
- -------------------------------------------------------------------------------------------------------------
<S>                                    <C>            <C>      <C>                      <C>    
Walter C. Herlihy                      --             --       20,000/80,000            $4,400/$17,600
James R. Rusche                        --             --       12,000/48,000            $2,640/$10,560
Daniel P. Witt                         --             --       12,000/48,000            $2,640/$10,560
</TABLE>


(1)      None of the Named Executive Officers exercised any stock options during
         the fiscal year ended March 31, 1997.

(2)      Represents the aggregate number of stock options held as of March 31,
         1997 which can and cannot be exercised pursuant to the terms and
         provisions of the applicable stock option agreements and the 1992
         Repligen Corporation Stock Option Plan (the "Plan").

(3)      The dollar values have been calculated by determining the difference
         between the fair market value of the securities underlying the options
         and the exercise price of the options. The fair market value of
         in-the-money options was calculated on the basis of the closing price
         per share for Common Stock on The Nasdaq National Market of $1.47 on
         March 31, 1997.

                            Compensation of Directors

      Drs. Schimmel and Rich, the Co-Chairmen of the Board of Directors, are
compensated pursuant to consulting agreements described below and receive no
separate compensation for attendance at meetings or otherwise as directors.

      Under the terms of the Plan, each non-employee director, beginning on
September 10, 1996, is granted an option to purchase 5,000 shares of Common
Stock at an option price equal to the fair market value of the Common Stock on
the date of grant, determined in accordance with the terms of the Plan (the
"Board Options"). These options vest in full on the first anniversary of the
date of the grant, provided such person is still a director on such anniversary.
Additionally, each newly-elected, non-employee director who joins the Board is
entitled to receive a Board Option to purchase 24,000 shares of Common Stock on
the date he or she joins the Board. These initial Board Options vest equally
over a three-year period from the date of grant. Board Options have a term of
ten years, subject to early termination in the event of death or removal or
resignation from the Board. No director is entitled to receive Board Options
covering more than an aggregate of 50,000 shares.

      The Company paid Drs. Schimmel and Rich $49,200 and $43,200, respectively,
during the fiscal year ended March 31, 1997 pursuant to consulting agreements
which have similar terms. These agreements are automatically extended for
successive one-year terms unless terminated by either party at least 90 days
prior to the next anniversary date. Dr. Schimmel's agreement continues until
September 30, 1997 and Dr. Rich's agreement continues until


                                       7
<PAGE>



October 31, 1997. Drs. Schimmel and Rich have advised the Company that they have
no present intention of terminating their agreements.

Executive Employment Agreements

      On March 14, 1996, the Company entered into a letter of agreement with
Drs. Herlihy, Rusche, and Witt in connection with the Company's acquisition and
merger with Glycan Pharmaceuticals, Inc. (the "Herlihy Agreement," the "Rusche
Agreement," and the "Witt Agreement," respectively). Under the terms of the
Herlihy Agreement, Dr. Herlihy is entitled to a minimum salary of $160,000 per
annum, subject to periodic increases at the discretion of the Board of
Directors. Additionally, Dr. Herlihy is eligible for participation in all of the
Company's welfare, profit sharing, retirement and savings plans on the same
basis as other employees of the Company. Dr. Herlihy received a stock option to
purchase 100,000 shares of the Common Stock at $1.25 per share, vesting at 20%
per annum over five years pursuant to the Herlihy Agreement. Dr. Herlihy's
employment may be terminated, with or without cause, by either party upon 30
days prior written notice. In such event, Dr. Herlihy would be entitled to
continue receiving his salary for a period of eight months or until he finds
other employment, whichever occurs first.

      Under the terms of the Rusche Agreement, Dr. Rusche is entitled to a
minimum salary of $115,000 per annum, subject to periodic increases at the
discretion of the Board of Directors. Additionally, Dr. Rusche is eligible for
participation in all of the Company's welfare, profit sharing, retirement and
savings plans on the same basis as other employees of the Company. Dr. Rusche
received a stock option to purchase 60,000 shares of the Common Stock at $1.25
per share, vesting at 20% per annum over five years pursuant to the Rusche
Agreement. Dr. Rusche's employment may be terminated, with or without cause, by
either party upon 30 days prior written notice. In such event, Dr. Rusche would
be entitled to continue receiving his salary for a period of six months or until
he finds other employment, whichever occurs first.

      Under the terms of the Witt Agreement, Dr. Witt is entitled to a minimum
salary of $115,000 per annum, subject to periodic increases at the discretion of
the Board of Directors. Additionally, Dr. Witt is eligible for participation in
all of the Company's welfare, profit sharing, retirement and savings plans on
the same basis as other employees of the Company. Dr. Witt received a stock
option to purchase 60,000 shares of the Common Stock at $1.25 per share, vesting
at 20% per annum over five years pursuant to the Witt Agreement. Dr. Witt's
employment may be terminated, with or without cause, by either party upon 30
days prior written notice. In such event, Dr. Witt would be entitled to continue
receiving his salary for a period of six months or until he finds other
employment, whichever occurs first.

Compensation Committee Interlocks and Insider Participation

      The Compensation Committee currently consists of Dr. Schimmel and Mr.
Miller. No member of the Compensation Committee is a current or former employee
of the Company. There are no Compensation Committee interlocks between the
Company and any other entities involving any of the executive officers or
directors of such entities.


            STOCK OWNERSHIP OF PRINCIPAL STOCKHOLDERS AND MANAGEMENT

      The following table sets forth certain information as of June 9, 1997
concerning beneficial ownership by (i) all shareholders known by the Company to
own more than five 

                                       8
<PAGE>

percent of the Company's outstanding voting securities, (ii) each of the Named
Executive Officers, (iii) each director or nominee, and (iv) all current
directors and executive officers as a group.

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------
                                                 Number of    Shares    Percentage of
Name and Address of Beneficial Owners         Beneficially  Owned (1)    Common Stock
                                                                             (2)     
<S>                                              <C>           <C>           <C> 
Funds managed by Paramount Capital Asset         2,057,700     (3)           12.9
        Management, Inc.
787 Seventh Avenue
New York, NY 10019
                                                               
Paul Schimmel, Ph.D.                               611,732     (4)           3.8%
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02139
                                                               
Alexander Rich, M.D.                               430,700     (5)           2.7%
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02139
                                                               
G. William Miller                                   66,000     (6)            *
G. William Miller & Co., Inc.
1215 19th Street NW
Washington, DC 20036
                                                               
Walter C. Herlihy                                  149,668     (7)            *
Repligen Corporation
117 Fourth Avenue
Needham, MA 02194
                                                                  
James R. Rusche                                    121,668     (8)            *
Repligen Corporation
117 Fourth Avenue
Needham, MA 02194
                                                               
Daniel P. Witt                                     107,668     (9)            *
Repligen Corporation
117 Fourth Avenue
Needham, MA 02194

All directors and executive                                    
   officers as group (6 persons)                 1,487,436     (10)          9.3%

- ---------------------------------------------------------------------------------------
</TABLE>


(1)       Except as otherwise indicated, the persons named in the table have
          sole voting and investment power with respect to all shares of Common
          Stock beneficially owned by them. The number of shares of Common Stock
          deemed outstanding includes shares issuable pursuant to options held
          by the respective person or group, which


                                       9
<PAGE>



          may be exercised within 60 days after the date of this Proxy Statement
          ("presently exercisable stock options"), as set forth below.
(2)       As of June 9, 1997, there were 16,001,785 shares of the Company's
          Common Stock outstanding. Pursuant to the rules of the Securities and
          Exchange Commission, presently exercisable stock options held by a
          person or group are deemed outstanding for the purpose of computing
          the percentage ownership of such person or group.
(3)       Consists of 1, 398,100 shares of Common Stock owned by The Aries
          Trust, a Cayman Islands Trust (the "Aries Trust") , and 659,600 shares
          of Common Stock owned by Aries Domestic Fund, L.P., a Delaware limited
          partnership (the "Aries Domestic Fund"). Paramount Capital Asset
          Management, Inc. ("Paramount") is the general partner of Aries
          Domestic Fund and is the investment manager of the Aries Trust.
          Paramount disclaims beneficial ownership of all such shares except to
          the extent of its pecuniary interest therein.
(4)       Includes shares held jointly with Dr. Schimmel's spouse; also includes
          26,650 shares held in a charitable trust of which Dr. Schimmel is a
          trustee; excludes shares held by Dr. Schimmel's adult children. Dr.
          Schimmel disclaims beneficial ownership of the shares held by these
          children.
(5)       Includes 60,000 shares held by Dr. Rich's spouse; excludes shares held
          by Dr. Rich's adult children. Dr. Rich disclaims beneficial ownership
          of the shares held by these children.
(6)       Includes 6,000 shares beneficially owned by Mr. Miller which may be
          acquired within 60 days pursuant to presently exercisable stock
          options.
(7)       Includes 20,000 shares beneficially owned by Dr. Herlihy which may be
          acquired within 60 days pursuant to presently exercisable stock
          options.
(8)       Includes 12,000 shares beneficially owned by Dr. Rusche which may be
          acquired within 60 days pursuant to presently exercisable stock
          options.
(9)       Includes 12,000 shares beneficially owned by Dr. Witt which may be
          acquired within 60 days pursuant to presently exercisable stock
          options.
(10)      Includes 50,000 shares beneficially owned by all executive officers
          and directors as a group which may be acquired within 60 days pursuant
          to presently exercisable stock options.

*         Represents less than 1% of the outstanding shares.

      COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934

          Section 16(a) of the Securities Exchange Act of 1934 requires the
Company's directors, executive officers, and persons who own more than ten
percent of the Company's Common Stock, to file with the Securities and Exchange
Commission ("SEC") initial reports of ownership and reports of changes in
ownership of Common Stock of the Company. Officers, directors and greater than
ten-percent shareholders are required by SEC regulation to furnish the Company
with copies of all Section 16(a) reports they file. Except as set forth below,
to the Company's knowledge, based solely upon review of the copies of such
reports furnished to the Company and written representations that no other
reports were required, during the fiscal year ended March 31, 1997, all Section
16(a) filing requirements applicable to its officers, directors and greater than
ten-percent beneficial owners were fulfilled in a timely manner. The table below
shows the officers and directors who failed to file reports required by Section
16(a) during the last fiscal year, showing, for each of them, the number of late
reports, the number of transactions that were not reported on a timely basis
and, to the Company's knowledge, the number of reports not filed.



                                       10
<PAGE>


              Name          Late Reports     Reports Not Filed     Transactions
              ----          ------------     -----------------     ------------
Walter C. Herlihy, Ph.D.          1                 0                   1
James R. Rusche, Ph.D.            1                 0                   1
Daniel P. Witt, Ph.D.             1                 0                   1


The Company is assisting its officers and directors in bringing their Section
16(a) reports up to date and has taken steps to assist them in complying with
their reporting obligations in the future.

                  COMPENSATION COMMITTEE REPORT TO STOCKHOLDERS

         The Compensation Committee which meets on a periodic basis, is
comprised of two non-employee members of the Board of Directors. The Committee
formulates and administers the Company's compensation policies for the President
and Chief Executive Officer and all vice presidents of the Company. The
Committee is also responsible for determining to whom and under what terms stock
options should be granted (other than options which are automatically granted to
members of the Board of Directors) under the Plan and the amount of
contributions to the Company's Employee Stock Ownership Plan.

Compensation Philosophy

         In designing its compensation programs, the Company takes into account
a number of considerations, some relevant to companies in general and some
relevant primarily to biotechnology and other research and development intensive
companies. The ultimate goal of the Company's compensation program is to
motivate each employee to enhance stockholder value, to provide a fair reward
for this effort, and to stimulate each employee's professional and personal
growth. In addition, the Company's compensation program attempts to achieve the
following:

[bullet]  Provide compensation which is consistent with the Company's annual and
          long-term objectives and achievements.

[bullet]  Promotion and reward of individual initiative, effort and
          accomplishment.

[bullet]  Establishment of a competitive total compensation package that enables
          the Company to attract and retain qualified and motivated personnel.

Performance Criteria

         Since the Company is still in the process of developing its proprietary
products and because of the highly volatile nature of biotechnology stocks in
general, it is not appropriate to use the traditional performance standards,
such as profit levels and stock performance, to measure the success of the
Company and an individual's contribution to that success.

         Accordingly, the compensation of executive officers is based, for the
most part, on the achievement of certain goals by the Company as a whole and the
individual (and his or 


                                       11
<PAGE>

her business unit) concerned. The Committee therefore examines three specific
areas in formulating the compensation packages of its five most senior
executives. Criteria and specific goals within each category are as follows:

          Company Performance:

[bullet]  The extent to which key research, clinical, product manufacturing,
          product sales and financial objectives of the Company have been met
          during the preceding fiscal year.

[bullet]  The development, acquisition and licensing of key technology.

[bullet]  The achievement by the Company of certain milestones, whether
          specified in agreements with third party collaborators or determined
          internally.

          Executive Performance:

[bullet]  An executive's involvement in and responsibility for the development
          and implementation of strategic planning and the attainment of
          strategic objectives of the Company.

[bullet]  The participation by an executive in the relationship between the
          Company and the investment community.

[bullet]  The involvement of an executive in personnel recruitment, retention
          and morale.

[bullet]  The responsibility of the executive in working within budgets,
          controlling costs and other aspects of expense management.

          Other Factors:

[bullet]  The necessity of being competitive with companies in the
          pharmaceutical and biotechnology industries, taking into account
          relative company size, stage of development, performance and
          geographic location as well as individual responsibilities and
          performance.

Mix of Compensation

      The Company's executive compensation has four principal components: base
salary; annual cash bonuses; incentive and/or non-qualified stock options; and
miscellaneous benefits.

      In each case, the Committee regularly compares the individual elements
comprising the Company's executives' mix of compensation to that of a similar
group of other biotechnology companies.

      The comparison group is based on a multi-tiered classification of
representative companies within the biotechnology industry according to numerous
characteristics, including but not limited to company size, the number of
proprietary products, stage of development of the company's products and total
revenues. The tiered classification of 


                                       12
<PAGE>

biotechnology companies is reviewed annually and, if appropriate, revised as
members of such tiers change from year to year.

      After completing a review of the comparison group's compensation policies,
the Committee determines competitive compensation levels for each executive
position.

      Levels of base salary are reviewed on an annual basis by the Committee.
Base salary may be altered in line with changes in compensation amongst the
companies included in the Committee's comparison group and further adjusted if
the committee determines that an executive's contribution to the Company has
increased or decreased.

      Annual cash bonuses are voted in April and calculated as a percentage of
an executive's base salary as determined by both the bonus schedule that is
established at the beginning of each fiscal year and by the various criteria set
forth above. Stock options are also awarded from time to time based upon the
same criteria and are intended both to retain and reward the executive and to
provide further incentive for him or her to continue contributing to the
long-term success of the Company.



Respectfully submitted by the Compensation Committee,

G. William Miller
Paul Schimmel, Ph.D.

      The report of the Compensation Committee shall not be deemed incorporated
by reference by any general statement incorporating by reference this proxy
statement into any filing under the Securities Act of 1933 or under the
Securities Act of 1934, except to the extent that the Company specifically
incorporates this information by reference, and shall not otherwise be deemed
filed under such Acts.

                          STOCK PRICE PERFORMANCE GRAPH

      The following graph illustrates a comparison of the cumulative stockholder
return (change in stock price plus reinvested dividends) of the Company's Common
Stock with the Nasdaq Stock Market Index (U.S.) (the "Nasdaq Composite Index")
and the Nasdaq Pharmaceutical Stock Index (the "Nasdaq Pharmaceutical Index").
The comparisons in the graph are required by the Securities and Exchange
Commission and are not intended to forecast or be indicative of possible future
performance of the Company's Common Stock.


                                       13
<PAGE>


[line chart]
                            STOCK PERFORMANCE CHART

             RGEN Closing       Nasdaq Pharmaceutical        Nasdaq Stock
YEAR          Stock Price            Stock Index          Market Index (U.S.)
- ----          -----------            -----------          -------------------
1992              100                    100                      100
1993              44                     69                       115
1994              32                     70                       124
1995              11                     70                       138
1996               7                     123                      187
1997               9                     112                      208



         Assumes $100 invested on March 31, 1992 in each of Repligen
Corporation's Common Stock, the securities comprising the Nasdaq Composite Index
and the securities comprising the Nasdaq Pharmaceutical Index.


                                       14
<PAGE>


                        PROPOSAL I -ELECTION OF DIRECTORS

         At the Meeting, four directors are to be elected to serve until their
successors are duly elected and qualified. The Board has designated the
individuals named below as nominees.


<TABLE>
<CAPTION>
       Name                              Age                       Positions
       ----                              ---                       ---------
<S>                                       <C>     <C>
Walter C. Herlihy, Ph.D. ..               45      President, Chief Executive Officer and Director (3)
G. William Miller..........               72      Director (1) (2) (3)
Alexander Rich, M.D........               72      Director (2)
Paul Schimmel, Ph.D........               56      Director (1) (3)
</TABLE>
- --------------------
(1) Member of the Compensation Committee
(2) Member of the Audit Committee
(3) Member of the Executive Committee

Proxies received from stockholders of the Company will be voted, unless
authority to so vote is withheld, for the election of the Board's nominees.
Authority to vote for any or all of the nominees may be withheld in the manner
indicated on the enclosed Proxy. If for any reason any of the nominees for
election to the Board becomes unavailable for election, the Proxies solicited
will be voted for such other nominees as are selected by the Board. The Board
has no reason to believe that any of the nominees will not be available or will
not serve if elected. All of the nominees for election at this Annual Meeting
were previously elected by the Company's stockholders as directors and currently
serve as directors of the Company. See "Biographical Information" for
information related to nominees for Director.

         The Board unanimously recommends a vote FOR each of the nominees for
election as directors.


         PROPOSAL II - RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

         Arthur Andersen LLP, certified public accountants, has been appointed
by the Board, upon recommendation of the Audit Committee of the Board, as
independent auditors for the Company to examine and report on its financial
statements for the 1998 fiscal year, which appointment is being submitted to the
stockholders for ratification at the Meeting. Representatives of Arthur Andersen
LLP are expected to be present at the Meeting, with the opportunity to make a
statement if they desire to do so, and to be available to respond to appropriate
questions. The appointment of the independent auditors will be ratified if it
receives the affirmative vote of the holders of a majority of shares of the
Common Stock of the Company present at the Meeting, in person or by proxy.
Submission of the appointment of the auditors to the stockholders for
ratification will not limit the authority of the Board to appoint another
accounting firm to serve as independent auditors if the present auditors resign
or their engagement is otherwise terminated.

         The Board recommends a vote FOR the ratification of Arthur Andersen LLP
as independent auditors.


                                       15
<PAGE>

                                VOTING PROCEDURES

      The representation, in person or by proxy, of at least a majority of the
outstanding shares of Common Stock entitled to vote at the Annual Meeting is
necessary to constitute a quorum for the transaction of business. Shares
represented by proxies pursuant to which votes have been withheld from any
nominee for director, or which contain one or more abstentions or broker
"non-votes," are counted as present or represented for purposes of determining
the presence or absence of a quorum for the Annual Meeting. A "non-vote" occurs
when a broker or other nominee holding shares for a beneficial owner votes on
one proposal, but does not vote on another proposal because the broker does not
have discretionary voting power and has not received instructions from the
beneficial owner.

      Election of Directors. Directors are elected by plurality of the votes
cast, in person or by proxy, at the Annual Meeting. The four nominees who
receive the highest number of affirmative votes of the shares present or
represented and voting on the election of directors at the Annual Meeting will
be elected Directors for a one-year term. Shares present or represented and not
so marked as to withhold authority to vote for a particular nominee will be
voted in favor of a particular nominee and will be counted toward such nominee's
achievement of a plurality. Shares present at the meeting or represented by
proxy where the stockholder properly withholds authority to vote by marking the
"WITHHOLD" box on the proxy for such nominee will not be counted toward such
nominee's achievement of plurality.

      Other Matters. For all other matters being submitted to stockholders at
the Annual Meeting, the affirmative vote of the majority of shares present, in
person or represented by proxy, and voting on that matter is required for
approval. Shares voted to abstain are included in the number of shares present
or represented and voting on each matter. Shares subject to broker "non-votes"
are not considered to have been voted for the particular matter and have the
practical effect of reducing the number of affirmative votes required to achieve
a majority for such matter by reducing the total number of shares from which the
majority is calculated.

      Boston EquiServe L.P. will serve as the Inspector of Elections and will 
count all votes and ballots.

                             STOCKHOLDERS' PROPOSALS

      Any proposal by a stockholder of the Company intended to be presented at
the 1998 Annual Meeting of Stockholders must be received by the Company at its
principal executive office not later than February 1, 1998 for inclusion in the
Company's proxy statement and form of proxy relating to that meeting. Any such
proposal must also comply with the other requirements of the proxy solicitation
rules of the SEC.

                                 OTHER BUSINESS

      Management does not know of any other matters to be brought before the
Meeting except those set forth in the notice thereof. If other business is
properly presented for consideration at the Meeting, it is intended that the
Proxies will be voted by the persons named therein in accordance with their
judgment on such matters.

         Even if you plan to attend the Meeting in person, please sign, date and
return the enclosed Proxy promptly. A postage-paid return-addressed envelope is
enclosed for your convenience. Your cooperation in giving this matter your
immediate attention and in returning your proxies will be appreciated.


                                       16
<PAGE>

                                    EXPENSES

      The cost of solicitation will be borne by the Company, and in addition to
directly soliciting stockholders by mail, the Company may request banks and
brokers to solicit their customers who have stock of the Company registered in
the name of the nominee and, if so, will reimburse such banks and brokers for
their reasonable out-of-pocket costs. Solicitation by officers and employees of
the Company may also be made of some stockholders in person or by mail or
telephone following the original solicitation. The Company may, if appropriate,
retain an independent proxy solicitation firm to assist the Company in
soliciting proxies. If the Company does retain a proxy solicitation firm, the
Company would pay such firm's customary fees and expenses.

June 19, 1997

                                       17




<PAGE>

                                                                      Appendix A
Dear Shareholder:

Please take note of the important information enclosed with this Proxy. There
are a number of issues related to the operation of the Company that require your
immediate attention.

Your vote counts, and you are strongly encouraged to exercise your right to vote
your shares.

Please make the boxes on the proxy card to indicate how your shares will be
voted. Then sign the card, detach it and return your proxy in the enclosed
postage paid envelope.

Thank you in advance for your prompt consideration of these matters.

Sincerely,

Repligen Corporation


                                  DETACH HERE


[ X ]  Please mark vote as in this example

THE SHARES REPRESENTED BY THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO
DIRECTIONS IS GIVEN, WILL BE VOTED FOR THE ELECTION OF DIRECTORS AND FOR THE
PROPOSALS IN ITEMS 2 AND 3, AND AUTHORITY WILL BE DEEMED GRANTED UNDER ITEM 4
TO HAVE THE PROXIES VOTE UPON SUCH ADJOURNMENTS THEREOF.

1.  To elect four persons to the Board of Directors for the ensuing year.
    Nominees:  Alexander Rich, M.D., Paul Schimmel, Ph.D., Walter C. Herlihy,
    G. William Miller

                 FOR                  WITHHELD
                 [  ]                  [  ]


[   ] ----------------------                       MARK HERE FOR
For all nominees except as                         ADDRESS CHANGE
noted above                                        AND NOTE BELOW     [   ]

                                                 FOR   AGAINST   ABSTAIN
2.  To ratify the selection of the firm of       [  ]    [  ]      [  ]
    Arthur Andersen LLP as independent auditors
    of the Corporation for the fiscal year
    ending March 31, 1998.

3.  IN THEIR DISCRETION, THE PROXIES ARE AUTHORIZED TO VOTE UPON SUCH OTHER
    MATTERS AS MAY PROPERLY COME BEFORE THE MEETING OR ANY ADJOURNMENT THEREOF.


                                         (If signing as attorney, executor,
                                         trustee, or guardian, please give your
                                         full title as such. If stock is held
                                         jointly, each owner should sign.)


Signature:                Date:        Signature:              Date:
          ---------------      ------             ------------      ------

<PAGE>

                              REPLIGEN CORPORATION
                               117 FOURTH AVENUE
                               NEEDHAM, MA 02194

                      SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF SHAREHOLDERS


     The undersigned hereby appoints Walter C. Herlihy and Daniel P. Witt, and
each of them alone, proxies with full power of substitution, to vote all shares
of Common Stock of the Corporation with the undersigned is entitled to vote at
the Annual Meeting of Shareholders of Repligen Corporation to be held on 
Thursday, July 24, 1997 at 10:00 a.m., local time, at the offices of the
Corporation, 117 Fourth Avenue, Needham, Massachusetts 02194 any adjournments
thereof, upon matters set forth in the Notice of Annual Meeting of Shareholders
and Proxy Statement dated June 9, a copy of which has been received by the
undersigned. The proxies are further authorized to vote, in their discretion,
upon such other business as may be incidental to the meeting or any adjournments
thereof.


                                                              [SEE REVERSE SIDE]

                   CONTINUED AND TO BE SIGNED ON REVERSE SIDE


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