REPLIGEN CORP
SC 13D/A, 1998-01-08
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D/A
                                (Amendment No.7)

                    Under the Securities Exchange Act of 1934


                              Repligen Corporation
                                (Name of Issuer)


                     Common Stock, par value $.01 per share
                         (Title of Class of Securities)

                                    759916109
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372

       (Name, Address and Telephone Number of Person Authorized to Receive
                           Notices and Communications)


                                 January 2, 1998
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                                        [_]

Check the following box if a fee is being paid with this Statement:
                                                                        [_]



                               Page 1 of 13 Pages

<PAGE>


                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 2 of 13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Paramount Capital Asset Management, Inc.         
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          2,307,700
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        2,307,700
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         2,307,700
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         14.4%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 3 of 13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Aries Domestic Fund, L.P.         
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          744,500
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        744,500
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         744,500
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         4.6%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 4 of 13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         The Aries Trust 
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          1,563,200
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        1,563,200
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         1,563,200
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         9.7%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------


<PAGE>

                                  SCHEDULE 13D
CUSIP No.  [759916109]                                     Page 5 of 13 Pages
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Lindsay A. Rosenwald, M.D.         
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          2,307,700
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        2,307,700
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         2,307,700
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         14.4%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------


<PAGE>
Item 1.  Security and Issuer.

         (a)      Common Stock, $.01 par value ("Shares")

                  Repligen Corporation
                  117 Fourth Avenue
                  Needham, MA 02194
                  617-449-9560

Item 2.  Identity and Background.

         Names of Persons Filing:

         (a)      This  statement is filed on behalf of Paramount  Capital Asset
                  Management,  Inc. ("Paramount Capital"),  Aries Domestic Fund,
                  L.P. ("Aries  Domestic"),  The Aries Trust ("Aries Trust") and
                  Lindsay A. Rosenwald,  M.D. ("Dr.  Rosenwald" and collectively
                  with Paramount  Capital,  Aries Domestic and Aries Trust,  the
                  "Reporting  Parties").  See attached Exhibit A which is a copy
                  of their agreement in writing to file this statement on behalf
                  of each of them.

         (b)      The business address of Paramount Capital,  Aries Domestic and
                  Dr.  Rosenwald  is 787  Seventh  Avenue,  New York,  New York,
                  10019. The business address for Aries Trust is c/o MeesPierson
                  (Cayman)  Limited,  P.O. Box 2003,  British  American  Centre,
                  Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

         (c)      Dr.  Rosenwald is an investment  banker,  venture  capitalist,
                  fund manager and sole  shareholder of Paramount  Capital,/1/ a
                  Subchapter  S  corporation   incorporated   in  the  State  of
                  Delaware.  Paramount  Capital is the General  Partner of Aries
                  Domestic,/2/ a limited  partnership  incorporated in Delaware.
                  Paramount Capital is the Investment Manager to Aries Trust,/3/
                  a Cayman Islands Trust.


         (d)      The   Reporting   Parties  and  their   respective   officers,
                  directors, general partners,  investment managers, or trustees
                  have not, during the five years prior to the date hereof, been
                  convicted  in  a  criminal   proceeding   (excluding   traffic
                  violations or similar misdemeanors).

         (e)      The   Reporting   Parties  and  their   respective   officers,
                  directors, general partners,  investment managers, or trustees
                  have not been, during the five years prior to the date hereof,
                  parties to a civil proceeding of a judicial or  administrative
                  body of competent jurisdiction,
- --------
                  1     Please see attached  Exhibit B indicating  the executive
                        officers  and   directors   of  Paramount   Capital  and
                        providing  information  called  for by Items 2-6 of this
                        statement as to said officers and  directors.  Exhibit B
                        is herein incorporated by reference.
                  
                  2     Please see  attached  Exhibit C  indicating  the general
                        partner  of Aries  Domestic  and the  general  partner's
                        executive   officers   and   directors   and   providing
                        information called for by Items 2-6 of this statement as
                        to  said  general  partners,   officers  and  directors.
                        Exhibit C is herein incorporated by reference.

                  3     Please see attached  Exhibit D indicating the investment
                        manager of the Aries Trust and the investment  manager's
                        executive   officers   and  direc  tors  and   providing
                        information called for by Items 2-6 of this statement as
                        to said  investment  manager and officers and directors.
                        Exhibit D is herein incorporated by reference.


                                        6

<PAGE>

                  as a result  of  which  such  person  was or is  subject  to a
                  judgment,  decree or final order enjoining  future  violations
                  of, or prohibiting or mandating activities subject to, Federal
                  or State securities laws or finding any violation with respect
                  to such laws.

         (f)      Dr. Rosenwald is a citizen of the United States.

Item 3.           Source and Amount of Funds or Other Consideration.

                  As previously  reported in the original  statement on Schedule
                  13-D (the "Original Statement") filed by the Reporting Parties
                  on  November  15,  1996,  in  connection  with  their  initial
                  acquisition  of shares of the Issuer,  Aries Domestic used its
                  general funds to effect the purchase of 292,000  shares of the
                  Issuer in various open market  transactions for an approximate
                  aggregate  purchase price of $407,258 and Aries Trust used its
                  general funds to effect its initial purchase of 658,000 shares
                  for an approximate aggregate purchase price of $916,692. As of
                  the  date of the  last  filing  of a  Schedule  13D  Amendment
                  ("Amendment No. 6"), Aries Domestic beneficially owned 678,600
                  shares of the Issuer and the Aries  Trust  beneficially  owned
                  1,434,100  shares of the Issuer.  Since the date of  Amendment
                  No. 6, Aries  Domestic  used its  general  funds to effect the
                  purchase of the an additional 65,900 shares of common stock of
                  Issuer in various  open  market  transactions  as further  set
                  forth in Item 5 for an approximate aggregate purchase price of
                  $73,466.98.  Since the date of  Amendment  No. 6, Aries  Trust
                  used  its  general  funds to  effect  the  purchase  of the an
                  additional 129,100 shares of common stock of Issuer in various
                  open market transactions as further set forth in Item 5 for an
                  approximate aggregate purchase price of $143,759.27.

Item 4.           Purpose of Transaction.

                  The Reporting  Parties have acquired shares of Common Stock of
                  the Issuer as an investment in the Issuer.

                  Although  the  Reporting   Parties  have  not  formulated  any
                  definitive  plans,  they may  from  time to time  acquire,  or
                  dispose of, Common Stock and/or other securities of the Issuer
                  if and when they deem it  appropriate.  The Reporting  Parties
                  may formulate other purposes,  plans or proposals  relating to
                  any of such  securities  of the  Issuer to the  extent  deemed
                  advisable in light of market conditions,  investment  policies
                  and other factors.

                  Except  as  indicated  in this  Schedule  13D,  the  Reporting
                  Parties currently have no plans or proposals that relate to or
                  would result in any of the matters  described in subparagraphs
                  (a) through (j) of Item 4 of Schedule 13D.

Item 5.           Interest in Securities of the Issuer.

                  (a)      As of January 5, 1998,  Dr.  Rosenwald  and Paramount
                           Capital, through the acquisition of the shares by the
                           Aries Trust and Aries  Domestic,  beneficially  owned
                           2,307,700 shares or 14.2% of the Issuer's  securities
                           and Aries  Domestic and the Aries Trust  beneficially
                           owned as follows:

                                                              Amount Owned
                                                              ------------
                           Aries Domestic                       744,500 shares
                           Aries Trust                        1,563,200 shares

                  (b)      Dr.  Rosenwald and Paramount  Capital share the power
                           to vote or to  direct  the  vote,  to  dispose  or to
                           direct the  disposition of those shares owned by each
                           of Aries Domestic and Aries Trust.

                  (c)      The following  purchases  were made by Aries Domestic
                           in the open market since the filing of Amendment  No.
                           6:


                                        7

<PAGE>

<TABLE>
<CAPTION>

                           Date                      No. of Shares              Purchase Price
                           ----                      -------------              --------------
<S>                        <C>                           <C>                           <C>  
                           11/14/97                       17,000                        1.159
                           12/09/97                        6,600                        1.031
                           12/16/97                        5,000                        0.984
                            1/02/98                        8,500                        1.031
                            1/02/98                       11,900                        1.040
                            1/05/98                        3,400                        1.125

                           The following  purchases  were made by Aries Trust in
                           the open market since the filing of  Amendment No. 6:

                           Date                      No. of Shares              Market Price
                           ----                      -------------              ------------
                           11/14/97                       33,000                        1.159
                           12/09/97                       13,400                        1.031
                           12/16/97                       10,000                        0.984
                            1/02/98                       16,500                        1.031
                            1/02/98                       23,100                        1.040
                            1/05/98                        6,600                        1.125
</TABLE>

                           Other than as set forth herein the Reporting  Parties
                           have not  engaged in any  transactions  in the Common
                           Stock of the Issuer during the past 60 days.

                  (d) & (e)         Not applicable.


Item 6.           Contracts, Arrangements, Understandings or Relationships
                  with respect to Securities of the Issuer

                  Paramount Capital is the investment manager of the Aries Trust
                  and  the  General  Partner  of  Aries  Domestic  and  in  such
                  capacities  has  the  authority  to  make  certain  investment
                  decisions  on behalf  of such  entities,  including  decisions
                  relating to the securities of the Issuer.  In connection  with
                  its investment  management duties,  Paramount Capital receives
                  certain  management fees and performance  allocations from the
                  Aries  Trust and Aries  Domestic.  Dr.  Rosenwald  is the sole
                  shareholder of Paramount Capital.  Except as indicated in this
                  13D  and   exhibits,   there  is  no  contract,   arrangement,
                  understanding  or relationship  between the Reporting  Parties
                  and any other party or parties, with respect to any securities
                  of the Issuer.

Item 7.           Material to be Filed as Exhibits:

Exhibit A   -     Copy  of  an  Agreement  between   Dr.  Rosenwald,   Paramount
                  Capital, Aries Domestic and Aries Trust to file this Statement
                  on Schedule 13D on behalf of each of them.

Exhibit B   -     List  of   executive   officers  and   directors  of Paramount
                  Capital  and  information  called  for by  Items  2-6 of  this
                  statement relating to said officers and directors.

Exhibit C   -     List  of  executive  officers  and directors of Aries Domestic
                  and  information  called  for by Items  2-6 of this  statement
                  relating to said officers and directors.

Exhibit D   -     List  of  executive   officers   and  directors of Aries Trust
                  and  information  called  for by Items  2-6 of this  statement
                  relating to said officers and directors.


                                        8


<PAGE>

                                   SIGNATURES


                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   January 6, 1998
         New York, NY             By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      President


                                   ARIES DOMESTIC FUND, L.P.
                                   By: Paramount Capital Asset Management, Inc.
                                       General Partner

Dated:   January 6, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


                                   THE ARIES TRUST
                                   By: Paramount Capital Asset Management, Inc.
                                       Investment Manager

Dated:   January 6, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


Dated:   January 6, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.


                                        9

<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



                  The undersigned  hereby agree to jointly prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of  the  undersigned's  ownership  of  securities  of  Repligen
Corporation,  and hereby  affirm that such Schedule 13D is being filed on behalf
of each of the undersigned.

                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   January 6, 1998
         New York, NY             By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      President


                                   ARIES DOMESTIC FUND, L.P.
                                   By: Paramount Capital Asset Management, Inc.
                                       General Partner

Dated:   January 6, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


                                   THE ARIES TRUST
                                   By: Paramount Capital Asset Management, Inc.
                                       Investment Manager

Dated:   January 6, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


Dated:   January 6, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.


                                       10

<PAGE>

                                    EXHIBIT B

         The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                              PRINCIPAL OCCUPATION
         NAME                                    OR EMPLOYMENT
         ----                                    -------------

Lindsay A. Rosenwald, M.D.        Chairman of the Board, President of Paramount
                                  Capital Asset Management, Inc., Paramount
                                  Capital Investments, LLC and Paramount
                                  Capital, Inc.

Peter Morgan Kash                 Director of Paramount Capital Asset
                                  Management, Inc., Senior Managing Director,
                                  Paramount Capital, Inc.

Dr. Yuichi Iwaki                  Director of Paramount Capital Asset
                                  Management, Inc., Professor, University of
                                  Southern California School of Medicine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons (to the best of Paramount  Capital's  knowledge) has been convicted in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       11

<PAGE>




                                    EXHIBIT C

         The name and principal  occupation or employment of the General Partner
of Aries Domestic,  which is located at 787 Seventh Avenue,  New York, New York,
10019, is as follows:

                                                    PRINCIPAL OCCUPATION
         NAME                                          OR EMPLOYMENT
         ----                                          -------------

Paramount Capital Asset Management, Inc.     General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       12

<PAGE>

                                    EXHIBIT D

         The name and principal  occupation or employment,  which in the case of
Paramount Capital Asset Management,  Inc. is located at 787 Seventh Avenue, 44th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                 PRINCIPAL OCCUPATION
         NAME                                       OR EMPLOYMENT
         ----                                       -------------

Paramount Capital Asset Management, Inc.           Investment Manager

MeesPierson (Cayman) Limited                       Trustee
P.O. Box 2003
British American Centre
Phase 3, Dr. Roy's Drive
George Town, Grand Cayman

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       13



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