REPLIGEN CORP
10-Q, 1999-11-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
Previous: NUVEEN TAX EXEMPT UNIT TRUST STATE SERIES 111, 24F-2NT, 1999-11-15
Next: CLARIDGE HOTEL & CASINO CORP, NT 10-Q, 1999-11-15



<PAGE>






                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 10-Q

             [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF
                       THE SECURITIES EXCHANGE ACT OF 1934

                For the quarterly period ended September 30, 1999

                                       OR

            [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF
                       THE SECURITIES EXCHANGE ACT OF 1934

   For the transition period from ____________________ to ____________________

                         Commission File Number 0-14656

                              REPLIGEN CORPORATION
             (exact name of registrant as specified in its charter)

               Delaware                                      04-2729386
    (State or other jurisdiction of                       (I.R.S. Employer
    incorporation or organization)                         Identification No.)


             117 Fourth Avenue
         Needham, Massachusetts                                 02494
  (Address of principal executive offices)                    (Zip Code)

       Registrant's telephone number, including area code: (781) 449-9560

        -----------------------------------------------------------------
      (Former name, former address and former fiscal year, if changed since
                                 last report.)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15 (d) of the Securities Exchange Act of 1934
during the preceding 12 months (or for such shorter period that the registrant
was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes  x  No   .
                                       ___   ___

Indicate the number of shares outstanding of each of the issuer's classes of
common stock, as of October 31, 1999.

   COMMON STOCK, PAR VALUE $.01 PER SHARE                    22,320,310
   --------------------------------------                  ----------------
                Class                                      Number of Shares



<PAGE>


                              REPLIGEN CORPORATION

                                      INDEX


<TABLE>
<CAPTION>
                  PART I. FINANCIAL INFORMATION                                     PAGE


<S>                                                                                 <C>

Item 1.       Financial Statements

              Balance Sheets as of September 30, 1999 (Unaudited)
              and March 31, 1999                                                      3

              Statements of Operations (Unaudited) for the Three and Six
              Months Ended September 30, 1999 and 1998                                4

              Statement of Cash Flows (Unaudited) for the Six Months
              Ended September 30, 1999 and 1998                                       5

              Notes to Financial Statements (Unaudited)                               6

Item 2.       Management's Discussion and Analysis of Financial Condition
              and Results of Operations                                               9


                  PART II. OTHER INFORMATION

Item 1.       Legal Proceedings                                                      12

Item 2.       Changes in Securities                                                  13

Item 3.       Defaults Upon Senior Securities
              None

Item 4.       Submissions of Matters to a Vote of Security Holders                   13

Item 5.       Other Information
              None

Item 6.       Exhibits and Reports on Form 8-K                                       14

Signature                                                                            15

Exhibit Index                                                                        16

Exhibits                                                                             17

</TABLE>


                                       2
<PAGE>



  PART I.     FINANCIAL INFORMATION

  ITEM I.     FINANCIAL STATEMENTS


                              REPLIGEN CORPORATION
                                 BALANCE SHEETS
                                   (Unaudited)

<TABLE>
<CAPTION>
    ASSETS                                                      SEPTEMBER 30, 1999       MARCH 31, 1999
                                                                ------------------       --------------

<S>                                                             <C>                    <C>
Current assets:
  Cash and cash equivalents                                         $  10,912,517      $   3,250,751
  Accounts receivable                                                     487,522            429,720
  Inventories                                                             494,893            630,329
  Prepaid expenses and other current assets                               310,451            181,617
                                                                      ------------       ------------
    Total current assets                                               12,205,383          4,492,417
Property and equipment, at cost:
  Equipment                                                             1,089,331            944,644
  Furniture and fixtures                                                  155,890            101,376
  Leasehold improvements                                                  469,088            460,319
                                                                      ------------       ------------
                                                                        1,714,309          1,506,339
  Less: accumulated depreciation and amortization                       1,019,067            862,934
                                                                      ------------       ------------
                                                                          695,242            643,405

Other assets, net                                                          81,411             88,472
                                                                      ------------       ------------
                                                                    $  12,982,036      $   5,224,294
                                                                      ------------       ------------
                                                                      ------------       ------------

                  LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
  Accounts payable                                                  $     209,987      $     268,708
  Accrued expenses                                                        308,370            313,926
  Unearned income                                                            --               49,969
                                                                      ------------       ------------
     Total current liabilities                                            518,357            632,603

Commitments and contingencies                                                --                 --

Stockholders' equity:
  Preferred stock, $.01 par value --authorized - 5,000,000
   shares --outstanding - none                                               --                 --
  Common stock, $.01 par value --authorized - 40,000,000 shares
     --outstanding - 21,872,085 shares at September 30, 1999
     and 18,264,285 shares at March 31, 1999
                                                                          218,720            182,642
  Additional paid-in capital                                          140,335,872        131,272,607
  Accumulated deficit                                                (128,090,913)      (126,863,558)
                                                                      ------------       ------------
     Total stockholders' equity                                        12,463,679          4,591,691
                                                                      ------------       ------------

                                                                    $  12,982,036      $   5,224,294
                                                                      ------------       ------------
                                                                      ------------       ------------

</TABLE>


                 See accompanying notes to financial statements.


                                       3
<PAGE>

                              REPLIGEN CORPORATION
                             STATEMENT OF OPERATIONS
                                   (Unaudited)



<TABLE>
<CAPTION>
                                         THREE MONTHS ENDED SEPTEMBER 30,         SIX MONTHS ENDED SEPTEMBER 30,
                                             1999              1998             1999                1998

<S>                                     <C>              <C>              <C>              <C>
Revenues:
Research and development                $    232,344     $    470,032     $    610,847     $    738,438
Product                                      578,996          197,010          811,466          426,149
Investment income                            156,247           57,491          202,784          119,182
Other                                         14,438           37,648           45,095           70,836
                                        ------------     ------------     ------------     ------------

                                             982,025          762,181        1,670,192        1,354,604

Costs and expenses:
Research and development                     733,045          464,955        1,221,248          931,025
Selling, general and administrative          767,214          354,311        1,193,383          711,243
Cost of products sold                        286,534          141,991          482,917          254,273

                                        ------------     ------------     ------------     ------------

                                           1,786,793          961,258        2,897,548        1,896,541
                                        ------------     ------------     ------------     ------------

Net loss                                $   (804,768)    $   (199,077)    $ (1,227,356)    $   (541,937)
                                        ------------     ------------     ------------     ------------
                                        ------------     ------------     ------------     ------------
Basic and diluted net loss per share    $      (0.04)    $      (0.01)    $      (0.06)    $      (0.03)
                                        ------------     ------------     ------------     ------------
                                        ------------     ------------     ------------     ------------
Basic and diluted weighted average        21,867,601       18,001,785       20,324,426       18,001,785
common shares outstanding
                                        ------------     ------------     ------------     ------------
                                        ------------     ------------     ------------     ------------
</TABLE>



                 See accompanying notes to financial statements.


                                       4
<PAGE>


                              REPLIGEN CORPORATION
                            STATEMENTS OF CASH FLOWS
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                                      Six Months Ended September 30,
                                                                     --------------------------------
                                                                        1999                     1998
                                                                       ------                    -----

<S>                                                                <C>              <C>
Cash flows from operating activities
  Net loss                                                         $ (1,227,356)    $   (541,937)
  Adjustments to reconcile net loss to net cash
  used in operating activities -
  Depreciation and amortization                                         156,134          131,586
  Non cash charge for warrant issuance                                  188,265             --

Changes in assets and liabilities -
   Accounts receivable                                                  (57,802)        (247,862)
   Inventories                                                          135,436          (56,677)
   Prepaid expenses and other current assets                           (128,834)          79,115
   Accounts payable                                                     (58,721)          11,202
   Accrued expenses                                                      (5,556)         111,186
   Unearned income                                                      (49,969)         (33,332)
                                                                    ------------     -------------

     Net cash used in operating activities                           (1,048,403)        (546,719)

Cash flows from investing activities
   Purchases of property and equipment, at cost                        (207,970)         (78,951)
   Changes in other assets                                                7,061             --
                                                                    ------------     -------------
      Net cash used in investing activities                            (200,909)         (78,951)

Cash flows from financing activities:
   Net proceeds from the issuance of common stock and warrants,
   net of issuance costs                                              8,911,078             --
                                                                    ------------     -------------

      Net cash provided by financing activities                       8,911,078             --
                                                                    ------------     -------------

Net increase (decrease) in cash and cash equivalents                  7,661,766         (625,670)
Cash and cash equivalents, beginning of period                        3,250,751        4,725,544
                                                                    ------------     -------------
Cash and cash equivalents, end of period                           $ 10,912,517     $  4,099,874
                                                                    ------------     -------------
                                                                    ------------     -------------

</TABLE>


                 See accompanying notes to financial statements.


                                       5
<PAGE>


                              REPLIGEN CORPORATION
                          NOTES TO FINANCIAL STATEMENTS
                                   (UNAUDITED)

         1.       BASIS OF PRESENTATION

         The financial statements included herein have been prepared by Repligen
Corporation (the "Company" or "Repligen"), pursuant to the rules and regulations
of the Securities and Exchange Commission for quarterly reports on Form 10-Q and
do not include all of the information and footnote disclosures required by
generally accepted accounting principles. These financial statements should be
read in conjunction with the audited financial statements and notes thereto
included in the Company's Form 10-K for the year ended March 31, 1999.

         In the opinion of management, the accompanying unaudited financial
statements include all adjustments, consisting of only normal, recurring
adjustments, necessary to present fairly, the consolidated financial position,
results of operations and cash flows of the Company. The results of operations
for the interim periods presented are not necessarily indicative of results to
be expected for the entire year.

         The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the reported amounts of assets and liabilities and
disclosure of contingent assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the
reporting period. Actual results could differ from those estimates.

         2.       NET LOSS PER SHARE

         The Company has adopted Statement of Financial Accounting Standards
(SFAS) No. 128, EARNINGS PER SHARE, effective December 15, 1998. SFAS No. 128
establishes standards for computing and presenting earnings per share and
applies to entities with publicly held common stock or potential common stock.
The Company has applied the provisions of SFAS No. 128, retroactively to all
periods presented. Basic and diluted net loss per share represents net loss
divided by the weighted average number of common shares outstanding during the
period. The dilutive effect of the potential common shares consisting of
outstanding stock options and warrants is determined using the treasury stock
method in accordance with SFAS No. 128. Diluted weighted average shares
outstanding at September 30, 1999 and 1998 excluded the potential common shares
from warrants and stock options because to do so would be antidilutive for the
periods presented. At September 30, 1999, there are 1,332,791 options
outstanding with a weighted average exercise price of $1.94 and 3,307,050
warrants outstanding with a weighted average exercise price of $3.18. At
September 30, 1998, there are 1,042,000 options outstanding with a weighted
average exercise price of $1.34 and 2,832,000 warrants outstanding with a
weighted average exercise price of $3.97.

         3.       CASH AND CASH EQUIVALENTS

         The Company considers highly liquid investments purchased with original
maturities at the date of acquisition of three months or less to be cash
equivalents. Cash equivalents consist of the following at September 30, 1999 and
March 31, 1999:


                                       6
<PAGE>


<TABLE>
<CAPTION>
                                                   Three Months Ended
                                         September 30,1999    March 31, 1999
                                            (Unaudited)

<S>                                      <C>                  <C>
U.S. Government and Agency securities    $ 4,989,877          $ 1,197,624
Commercial paper                           3,963,497            1,136,119
Money markets                              1,797,830              802,755
Cash                                         161,313              114,253
                                          ----------           ----------
     Total cash and cash equivalents     $10,912,517          $ 3,250,751
                                          ----------           ----------
                                          ----------           ----------

</TABLE>



         4.       INVENTORIES

         Inventories are stated at the lower of cost (first-in, first-out) or
market and consist of the following:

<TABLE>
<CAPTION>
                                                 September 30, 1999   March 31,1999
                                                   (Unaudited)

<S>                                                      <C>            <C>
                Raw materials and work-in-process        $371,305       $412,480
                Finished goods                            123,587        217,849
                                                          -------        -------
                     Total                               $494,892       $630,329
                                                          -------        -------
                                                          -------        -------

</TABLE>


         Work in process and finished goods inventories consist of material,
labor, outside processing costs and manufacturing overhead.

         5.       COMPREHENSIVE INCOME

         Effective January 1, 1998, the Company adopted SFAS No. 130 REPORTING
COMPREHENSIVE INCOME, effective January 1, 1998. SFAS No. 130 establishes
standards for reporting and display of comprehensive income and its components
in financial statements. Comprehensive income includes all changes in equity
during a period except those resulting from investments by owners and
distributions to owners. The comprehensive net loss is the same as net loss for
all periods presented.

         6.       DISCLOSURES ABOUT SEGMENTS OF AN ENTERPRISE AND SIGNIFICANT
                  CUSTOMERS

         The Company has adopted SFAS No. 131, DISCLOSURES ABOUT SEGMENTS OF AN
ENTERPRISE AND RELATED Information, in the fiscal year ended March 31, 1999.
SFAS No. 131 establishes standards for reporting information regarding operating
segments in annual financial statements and requires selected information for
those segments to be presented in interim financial reports issued to
stockholders. SFAS No. 131 also establishes standards for related disclosures
about products and services and geographic areas. Operating segments are
identified as components of an enterprise about which separate discrete
financial information is available for evaluation by the chief operating
decision maker, or decision making group, in making decisions now to allocate
resources and assess performance. To date, the Company has viewed its operations
and manages its business as principally one operating segment. As a result, the
financial information disclosed herein, represents all of the material financial
information related to the Company's principal operating segment.


                                       7
<PAGE>


         The following table represents the Company's revenue by country:

<TABLE>
<CAPTION>
                           Three Months Ended              Six Months Ended
                              September 30,                  September 30,
                           1999            1998           1999           1998
                           ----            ----           ----           ----

    <S>                    <C>             <C>            <C>            <C>
    US                      61%             85%            59%            73%
    Europe                  38%             10%            39%            22%
    Other                    1%              5%             2%             5%
                           ----            ----           ---            ----
    Total                  100%            100%           100%           100%

</TABLE>


         During the three months ended September 30,1999, there were three
significant customers which accounted for approximately 12%, 10% and 11% of the
Company's revenues or $118,000 $100,000 and $105,300, respectively. The related
accounts receivable for these three customers at September 30, 1999 was $62,000,
$0 and $47,000, respectively.

         7.       SALE OF SECURITIES

         Pursuant to stock purchase agreements dated April 30, 1999 and May 14,
1999, respectively, Repligen issued in a private placement an aggregate of
3,600,000 shares of Common Stock for an aggregate purchase price of
approximately $9 million. Repligen closed the private placement transaction on
June 23, 1999. There were no underwriters involved in such private placement
transaction. Repligen filed a registration statement with the Securities and
Exchange Commission on Form S-3 on June 16, 1999 for the resale of the 3,600,000
shares of Common Stock sold to the parties in the private placement transaction.
The Securities and Exchange Commission declared such resale registration
statement effective on June 23, 1999.

         8.       SUBSEQUENT EVENT

         In October 1999 the Company licensed commercialization rights to two
diagnostic secretin products from ChiRhoClin Inc., a private company. These
products have been evaluated in clinical trials for the diagnosis of pancreatic
dysfunction and gastrinoma. A New Drug Application was filed with the FDA in May
1999 seeking approval to market synthetic porcine secretin for these
applications. ChiRhoClin has also conducted clinical studies for these
diagnostic indications with a human form of secretin which it intends to submit
to the FDA in 2000. Under terms of the agreement, Repligen paid $1,000,000 upon
execution of the agreement and, if the NDAs are approved, the Company will be
required to pay future milestones and royalties.


                                       8
<PAGE>





ITEM 2.       MANAGEMENT'S DISCUSSION AND ANALYSIS OF
              FINANCIAL CONDITION AND RESULTS OF OPERATIONS

         Cautionary Statement Regarding Forward-Looking Statements

         Statements in this Quarterly Report on Form 10-Q as well as oral
statements that may be made by the Company or by officers, directors or
employees of the Company acting on the Company's behalf, that are not historical
facts constitute "forward-looking statements" within the meaning of Section 21E
of the Securities Exchange Act of 1934. Such forward-looking statements involve
known and unknown risks, uncertainties and other factors that could cause the
actual results of the Company to be materially different from the historical
results or from any results expressed or implied by such forward-looking
statements. The Company's future operating results are subject to risks and
uncertainties and are dependent upon many factors, including, without
limitation, the Company's ability to (i) meet its working capital and future
liquidity needs, (ii) successfully implement its strategic growth strategies,
(iii) understand, anticipate and respond to rapidly changing technologies and
market trends, (iv) develop, manufacture and deliver high quality,
technologically advanced products on a timely basis to withstand competition
from competitors which may have greater financial, information gathering and
marketing resources than the Company, (v) obtain and protect licensing and
intellectual property rights necessary for the Company's technology and product
development on terms favorable to the Company, (vi) recruit and retain highly
talented professionals in a competitive job market, (vii) realize future
revenues, (viii) maintain a timeline for clinical activity, (ix) obtain
successful results of pending or future clinical trials, (x) continue to
establish collaborative arrangements with third parties, and (xi) compete
against the biotechnology and pharmaceutical industries. Further information on
potential factors that could affect the Company's financial results are included
in filings made by the Company from time to time with the Securities and
Exchange Commission included in the section entitled "Risk Factors" contained in
the Company's Annual Report on Form 10-K for the fiscal year ended March 31,
1999 (File No.000-14656).

         OVERVIEW

         Repligen develops new drugs for the treatment of autism, organ
transplantation and cancer. To expand our drug development program, in March
1999, we acquired the exclusive rights to patent applications for the use of
secretin in the treatment of autism. Autism is a developmental disorder
characterized by poor communication and social skills, negative behavior,
irregular sleep patterns and diminished ability to learn. Secretin is a hormone
produced in the small intestine which regulates the function of the pancreas as
part of the process of digestion. A form of secretin derived from pigs is
approved by the United States Food and Drug Administration for use in diagnosing
problems with pancreatic function. Recent anecdotal reports indicate that
secretin may have beneficial effects in treating autism, including improvements
in sleep, digestive function, speech and social behavior. Following media
reports of the potential benefits of secretin, more than 2,000 autistic children
have been treated with the pig-derived hormone. We intend to manufacture a
human, synthetic form of secretin and evaluate it in FDA approved clinical
trials in order to confirm the benefits of secretin in treating autism and to
determine the optimal dosing schedule. Currently there are no drugs approved by
the FDA for the treatment of autism.

         Repligen also is developing a product named "CTLA4-Ig," which has been
shown to suppress unwanted immune responses in animal models of organ
transplantation and autoimmune diseases, such as lupus or multiple sclerosis, in
which the immune system mistakenly attacks the body. Our product candidate is a
derivative of a natural protein whose role is to turn-off an immune response. In
animal models of organ transplantation and autoimmune diseases, CTLA4-


                                       9
<PAGE>


Ig has been shown to block the rejection of a transplanted organ or the effects
of the autoimmune disease. Initial clinical testing of CTLA4-Ig has been carried
out in patients receiving a bone marrow transplant, which is a potential cure
for several diseases of the immune system, including leukemia, myeloma, lymphoma
and sickle cell anemia. Despite the clinical success of bone marrow transplants,
a significant number of patients experience a severe and potentially
life-threatening complication known as Graft Versus Host Disease, in which the
newly transplanted immune system attacks the host (i.e., the patient). In June
1999, investigators from the Dana-Farber Cancer Institute, a research hospital
in Boston, reported in the NEW ENGLAND JOURNAL OF MEDICINE that treatment of
bone marrow from a family member with CTLA4-Ig prevented Graft Versus Host
Disease in eight of eleven transplant patients. Repligen intends to further
evaluate CTLA4-Ig in bone marrow transplantation for leukemia in collaboration
with the National Cancer Institute.

         In October 1999 we licensed commercialization rights to two diagnostic
secretin products from ChiRhoClin Inc., a private company. These products have
been evaluated in clinical trials for the diagnosis of pancreatic dysfunction
and gastrinoma. A New Drug Application was filed with the FDA in May 1999
seeking approval to market synthetic porcine secretin for these applications.
ChiRhoClin has also conducted clinical studies for these diagnostic indications
with a human form of secretin which it intends to submit to the FDA in 2000.

         Repligen develops, manufactures and markets products for the production
of therapeutic antibodies. We currently market a line of products for the
purification of antibodies based on a naturally occurring protein, Protein A,
which can specifically bind to antibodies. In December 1998, Repligen entered
into a ten year relationship to supply recombinant Protein A to Amersham
Pharmacia Biotech, a leading supplier to the biopharmaceutical market.

         RESULTS OF OPERATIONS

         REVENUES

          Total revenues for the three month period ended September 30, 1999 and
1998 were approximately $982,000 and $762,000, respectively, an increase of
approximately $220,000 or 29%. This increase was largely attributable to
increased product sales of recombinant Protein A and investment income. Year to
date total revenues increased approximately $316,000, or 23%, to $1,670,000 at
September 30,1999 from $1,355,000 at September 30,1998.

         Research and development revenues for the three month period ended
September 30, 1999 and 1998 were approximately $232,000 and $470,000,
respectively, a decrease of approximately $238,000 or 51%. The decrease in
quarterly revenue was largely attributable to a licensing payment received
during the three months ended September 30, 1998. Year to date revenues
decreased approximately $128,000 or 17% as a result of the discontinuation of
research collaborations on Repligen's drug discovery programs that generated
revenue during the six months ended September 30, 1998.

         Product revenues for the three month period ended September 30, 1999
and 1998 were approximately $579,000 and $197,000, respectively, an increase of
$382,000 or 194%. Year to date revenues increased 90% or approximately $385,000
to $811,000 from $426,000 at September 30, 1999 and 1998, respectively. This
increase is attributable to increased sales of Protein A products during such
periods.


                                       10
<PAGE>


         Investment income for the three month period ended September 30, 1999
and 1998 was approximately $156,000 and $57,000, respectively, an increase of
approximately $99,000 or 173%. Year to date revenue increased 71% or
approximately $84,000 to $203,000 from $119,000. These increases are largely
attributable to higher average funds available for investment arising
principally out of the completion of a private placement of common stock to
certain investors of $8,900,000 on June 23, 1999.

         Other revenues for the three month period ended September 30, 1999 were
approximately $15,000, a decrease of $23,000 or 61% from the comparable period
ended September 30, 1998. Year to date revenue was $45,000 and $71,000 for the
six months ended September 30, 1999 and 1998, respectively. This decrease is
primarily due to sales of unused equipment during fiscal year 1999.

         EXPENSES

         Total expenses for the three month period ended September 30, 1999 and
1998 increased to approximately $1,787,000 from $961,000, an increase of
$826,000 or 86%. For the six months ended September 30, 1999 and 1998, expenses
were $2,898,000 and $1,897,000, respectively, an increase of $1,001,000 or 35%.

         Research and development expenses for the three month period ended
September 30, 1999 and 1998 were approximately $733,000 and $465,000,
respectively, an increase of $268,000 or 58%. Year to date expenses were
$1,221,000 and $931,000 for the six month period September 30, 1999 and 1998,
respectively. These increases reflect costs associated with its drug development
programs for secretin and CTLA4-Ig.

         Selling, general and administrative expenses for the three months ended
September 30, 1999 and 1998 were approximately $767,000 and $354,000,
respectively, an increase of $413,000 or 117%. For the six month period ended
September 30, 1999 and 1998, respectively, selling, general and administrative
expenses were $1,193,000 and $711,000, respectively, an increase of $482,000 or
68%. This increase is attributable to non-recurring expenses associated with a
financial advisory agreement with a shareholder, including a non-cash charge for
the issuance of warrants exercisable for shares of Common Stock of Repligen
pursuant to an agreement signed during the quarter ended September 30, 1999.

         Cost of products sold for the three months ended September 30, 1999 and
1998 were approximately $287,000 and $142,000, respectively, an increase of
$145,000, or 102%. Year to date costs as of September 30, 1999 and 1998 were
$483,000 and $254,000, an increase of $229,000 or 90%. This increase is largely
attributable to costs associated with the commencement of its manufacturing
contract for AP Biotech. Cost of products sold in the three months ended
September 30, 1999 and 1998 were 50% and 72%, respectively, of product revenues
and for the six months ended September 30, 1999 and 1998, 60% and 60%,
respectively.

          LIQUIDITY AND CAPITAL RESOURCES

         Repligen's total cash and cash equivalents increased to $10,913,000 at
September 30, 1999 from $3,251,000 at March 31, 1999. This increase of
$7,662,000 reflects $8,900,000 of proceeds resulting from the sale of Common
Stock of Repligen to certain investors through a private placement that closed
during June 1999, offset by a net loss from operations incurred during the six
month period ended September 30, 1999 of approximately $1,227,000, an increase
in accounts receivable of $58,000 and an increase in


                                       11
<PAGE>


accounts payable of $59,000. Working capital increased to $11,762,000 at
September 30, 1999 from $3,860,000 at March 31, 1999.

         Repligen has entered into agreements with a number of collaborative
partners and licensees. Under the terms of these agreements, Repligen may be
eligible to receive research support, additional milestones or royalty revenue
if these collaborations result in clinical evaluation and commercialization of
products developed. The continuation of these collaborations or of receiving any
future payments related to these agreements cannot be guaranteed.

         While Repligen anticipates that the cost of operations will increase in
fiscal 2000 as Repligen expands its investment in proprietary product
development, Repligen believes that the private placement financing, yielding an
aggregate of $8,900,000 in net proceeds, will provide sufficient funding to
satisfy Repligen's working capital and capital expenditure requirements for the
next twenty-four months. Should Repligen need to secure additional financing to
meet its future liquidity requirements, Repligen may not be able to secure such
financing, or obtain such financing on favorable terms because of the volatile
nature of the biotechnology market place.

         YEAR 2000


         Repligen has undertaken an initial review of its information technology
computer systems and it believes that the Year 2000 problem does not pose
significant operational problems to its information technology systems. The
majority of Repligen's software and computer equipment has been purchased within
the last five years from third-party vendors who have already provided upgrades
intended to bring their products into Year 2000 compliance. Repligen has begun
to address the small number of internal systems that are not yet Year 2000
compliant, and expects full compliance by the end of 1999. Repligen currently
believes that the costs of addressing these issues should not exceed $50,000 and
will not have a material adverse impact on Repligen's financial position.

         Repligen has recently interviewed various third parties, including
vendors and suppliers of Repligen, to determine their exposure to Year 2000
issues, their anticipated risks and responses to those risks. To date, the third
parties that have been contacted have indicated that their hardware or software
is or will be Year 2000 compliant in a time frame that meets Repligen's
requirements. Even with the vendor compliance however, Repligen intends to
continue to assess its exposure to Year 2000 noncompliance on the part of any of
its material vendors. Repligen has no control, however, of whether the vendor's
systems will be Year 2000 compliant in a time frame satisfactory to Repligen.

         Repligen is working to establish a contingency plan in the event Year
2000 compliance cannot be achieved in a timely manner. A contingency plan will
be developed immediately upon completion of Repligen's Year 2000 compliance
assessment.

PART II.              OTHER INFORMATION

Item 1.           LEGAL PROCEEDINGS

         On July 17, 1998, Repligen filed a complaint against Bristol Meyers
Squibb ("BMS") at the United States District Court for the District of
Massachusetts in Boston, Massachusetts seeking correction of inventorship of
certain United States patents which claim compositions and methods of use for
CTLA4 as well as unspecified monetary damages. A correction of inventorship
would result in the University of Michigan being designated as a co-assignee on
any corrected BMS


                                       12
<PAGE>


patent. Repligen would then have rights to such technology pursuant to a 1992
License Agreement with the University of Michigan, a 1995 Asset Acquisition
Agreement with Genetics Institute, and other related agreements. On July 13,
1999, the court dismissed the complaint without prejudice citing a lack of legal
standing of Repligen to bring such a complaint. We believe that the court's
finding on standing was in error. The court did not rule on the validity of
Repligen's inventorship claim. Repligen continues to believe that the University
of Michigan is a rightful co-assignee of the aforesaid BMS patents and we intend
to continue to pursue the correction of inventorship. Repligen's failure to
obtain shared ownership rights in the patents may restrict Repligen's ability to
commercialize CTLA4-Ig.

Item 2.           CHANGES IN SECURITIES

         Pursuant to a Financial Advisory Agreement dated as of July 15, 1999 by
  and between Repligen and Paramount Capital, Inc. ("Paramount"), Repligen
  engaged Paramount as a non-exclusive financial adviser for an initial period
  of twelve months from the date thereof. In exchange and as consideration for
  Paramount's financial services, Repligen paid to Paramount $100,000 in cash
  and issued to Paramount (and its designees) warrants to purchase an aggregate
  of 100,000 shares of Common Stock of Repligen (the "Warrants"). Each Warrant
  is exercisable at $2.75 per share at any time prior to July 15, 2004. Repligen
  also agreed to pay Paramount additional fees to be agreed upon between the
  parties upon the consummation of certain equity financing transactions as set
  forth in the Financial Advisory Agreement. Based on certain representations by
  Paramount, Repligen had a reasonable belief that Paramount (and its designees)
  were acquiring the Warrants (and the shares issuable upon exercise thereof)
  for investment and not for distribution and that of the ten designees
  receiving the Warrants, at least five were "accredited" (as such term is
  defined under Rule 501 of the Securities Act of 1933). Pursuant thereto,
  Repligen issued the Warrants to such designees in a private placement
  transaction exempt from the registration requirements of the Securities Act of
  1933 pursuant to Regulation D, Rule 506 of the Securities Act of 1933. There
  were no underwriters in valued in such private placement transaction. Pursuant
  to the Financial Advisory Agreement, Repligen granted Paramount "piggy-back"
  registration rights with respect to the shares of Common Stock issuable upon
  exercise of the Warrants, and subject to the terms of the Financial Advisory
  Agreement, has agreed to register for resale the shares of Common Stock
  issuable upon exercise of the Warrants by May, 2000.

Item 4.        SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.

         The Company's Annual Meeting of Stockholders (the "Annual Meeting") was
     held on September 16, 1999. At the Annual Meeting, the stockholders of the
     Company considered and acted upon a proposal to: (i) elect five members to
     the Board of Directors (ii) ratify the selection of Arthur Andersen LLP as
     the independent auditors of the Company for the fiscal year ending March
     31, 1999 and (iii) amend Repligen's Restated Certificate of Incorporation
     to increase the number of authorized shares of Common Stock, par value $.01
     per share, from 30,000,000 shares to 40,000,000 shares.

         The Company had 21,868,085 shares of Common Stock of the Company issued
     and outstanding and entitled to vote as of the close of business on July
     23, 1999, the record date established by the Board of Directors for the
     Annual Meeting. At the Annual Meeting, holders of a total of 17,432,216
     shares of Common Stock or approximately 79% of all stockholders entitled to
     vote were present in person or represented by proxy. The following sets
     forth the information regarding the results of the voting at the Annual
     Meeting:


                                       13
<PAGE>


Proposal 1. Election of Directors:

<TABLE>
<CAPTION>
      Directors                              Shares Voting        Shares Voting
                                                 in Favor            Against
                                                 --------            -------

      <S>                                    <C>                  <C>
      Robert J. Hennessey*                      17,339,046               93,170
      Alexander Rich, M.D.*                     17,319,986              112,230
      Paul Schimmel, Ph.D.*                     17,344,971               87,245
      Walter C. Herlihy, Ph.D.*                 17,343,171               89,045
      G. William Miller*                        17,344,971              112,230

</TABLE>


* Incumbent

Proposal 2. Ratification of Selection of Arthur Andersen LLP as independent
auditors:

<TABLE>

      <S>                                    <C>
      Shares voting in favor:                17,376,364
      Shares voting against:                     28,307
      Abstention:                                27,545

</TABLE>


Proposal 3. Amend the Restated Certificate of Incorporation to increase the
number of authorized shares from 30,000,000 shares to 40,000,000 shares:

<TABLE>

      <S>                                    <C>
      Shares voting in favor:                17,986,570
      Shares voting against:                    408,026
      Abstention:                                37,620

</TABLE>


Item 6.           EXHIBITS AND REPORTS ON FORM 8-K

(a)      Exhibits

<TABLE>
<CAPTION>
       EXHIBIT           DESCRIPTION

<S>                      <C>
         3.1             Restated Certificate of Incorporation, dated
                         June 30, 1992 and filed July 13, 1992, as
                         amended (filed herewith)

         3.2             By-laws (filed as Exhibit 3.4 to Repligen
                         Corporation's Form S-1 Registration Statement
                         No. 33-3959 and incorporated herein by
                         reference).

         4.1          *  Form of Warrant Agreement (filed herewith)

       10.1          **  Financial Advisory Agreement with Paramount
                         Capital, Inc. (filed herewith)

       27.1              Financial Data Schedule (filed herewith)

</TABLE>


* Repligen issued a Common Stock Purchase Warrant to ten designees of Paramount
in connection with Paramount's services to Repligen. Each Warrant was identical
except for the number of shares of Common Stock issuable upon exercise of such
Warrant. ** The Exhibit A to the Financial Advisory Agreement, which is not
attached to the Financial Advisory Agreement, is filed by Repligen as Exhibit
4.1 hereunder.

         (b)      Reports on Form 8-K

                  The Company filed no current reports on Form 8-K during the
                  quarter covered by the report.


                                       14
<PAGE>

                                    SIGNATURE


         Pursuant to the requirements of the Securities Exchange Act of 1934,
     the registrant has duly caused this report to be signed on its behalf by
     the undersigned thereunto duly authorized.


                                     REPLIGEN CORPORATION
                                     (Registrant)


   Date:  November 15, 1999          By: /s/ Walter C. Herlihy
                                         ---------------------
                                     Chief Executive Officer and President,
                                     Principal Financial and Accounting Officer


                                       15
<PAGE>


                              Repligen Corporation
                                  Exhibit Index


<TABLE>
<CAPTION>
       EXHIBIT                     DESCRIPTION

       <S>                         <C>
         3.1                       Restated Certificate of Incorporation, dated
                                   June 30, 1992 and filed July 13, 1992, as
                                   amended (filed herewith)

         3.2                       By-laws (filed as Exhibit 3.4 to Repligen
                                   Corporation's Form S-1 Registration Statement
                                   No. 33-3959 and incorporated herein by
                                   reference).

         4.1                    *  Form of Warrant Agreement (filed herewith)

        10.1                    ** Financial Advisory Agreement with Paramount
                                   Capital, Inc. (filed herewith)

        27.1                       Financial Data Schedule (filed herewith)

</TABLE>


* Repligen issued a Common Stock Purchase Warrant to ten designees of Paramount
in connection with Paramount's services to Repligen. Each Warrant was identical
except for the number of shares of Common Stock issuable upon exercise of such
Warrant. ** The Exhibit A to the Financial Advisory Agreement, which is not
attached to the Financial Advisory Agreement, is filed by Repligen as Exhibit
4.1 hereunder.


                                       16

<PAGE>


EXHIBIT 3.1 RESTATED CERTIFICATE OF INCORPORATION


                          CERTIFICATE OF INCORPORATION
                                       OF
                              REPLIGEN CORPORATION

                Incorporated pursuant to an original Certificate
               of Incorporation filed with the Secretary of State
                                  May 29, 1981

                      We, the undersigned, for the purpose of restating the
     Certificate of Incorporation of Repligen Corporation (hereinafter referred
     to as the "corporation" or the "Company") under the laws of the State of
     Delaware, hereby certify as follows:

         FIRST. The name of the corporation is Repligen Corporation.

         SECOND. The address of the registered office of the corporation in the
State of Delaware is 32 Loockerman Square, Suite L-100, Dover, Kent County,
Delaware, 19901. The name of the registered agent of the corporation at such
address is The Prentice-Hall Corporation System, Inc.

         THIRD. The purpose of the corporation is to engage in any lawful act or
activity for which corporations may be organized under the General Corporation
Law of Delaware, and specifically, without limiting the generality of the
foregoing, to engage in research, development, manufacture and marketing of
products produced in part by application of genetic engineering techniques.

         FOURTH. The total number of shares of stock which the Company shall
have authority to issue is thirty-five million (35,000,000), of which thirty
million (30,000,000) shares shall constitute Common Stock ("Common Stock"), each
such share having a par value of one cent, and five million (5,000,000) shares
shall constitute Preferred Stock ("Preferred Stock"), each such share having a
par value of one cent.

         The powers, preferences and rights of the Common Stock and the
Preferred Stock shall be as set forth below:

                                 PREFERRED STOCK

         1. DESIGNATION OF SERIES BY BOARD OF DIRECTORS. The shares of Preferred
Stock may be divided by the Board of Directors into and issued in one or more
series, and each series shall be designated so as to distinguish the shares
thereof from the shares of all other series. All shares of Preferred Stock shall
be identical with all other shares of Preferred Stock, except in respect of
particulars which may be fixed by the Board of Directors as hereinafter provided
pursuant to the authority which is hereby expressly vested in the Board of
Directors. Each share of a series shall be identical in all respects with all
other shares of such series, except as to the date from which dividends thereon
(if any) shall be cumulative on any series as to which dividends are cumulative.

         2. TERMS THAT MAY BE SET BY BOARD OF DIRECTORS. Before any shares of
Preferred Stock of any series shall be issued, the Board of Directors, pursuant
to authority hereby expressly vested in it, shall fix by resolution or
resolutions the following provisions in respect of the shares for each such
series provided that such provisions are not inconsistent with the provisions of
this Article FOURTH applicable to shares of all series of Preferred Stock then
outstanding:

            (a) The distinctive designations of each such series and the number
         of shares which shall constitute such series, if any, which number may
         be increased (except where otherwise provided by the Board of Directors
         in creating such series) or decreased (but not below the number of
         shares thereof then outstanding) from time to time by like action of
         the Board of Directors;


                                       17
<PAGE>


            (b) The annual rate or amount of dividends payable on shares of such
         series, if any, whether such dividends shall be cumulative or
         non-cumulative, the conditions upon which and/or the dates when such
         dividends shall be payable and the date from which dividends on
         cumulative series shall accrue and be cumulative on all shares of such
         series issued prior to the payment date for the first dividend of such
         series;

            (c) Whether such series shall be redeemable or callable and, if so,
         the terms and conditions of such redemption or call, including the time
         or times when and the price or prices at which shares of such series
         shall be redeemed or called, and including the terms and conditions of
         any retirement or sinking fund for the purchase or redemption of shares
         of such series;

            (d) The amount payable on shares of such series in the event of
         liquidation, dissolution or winding up of the affairs of the Company;

            (e) Whether such series shall be convertible into or exchangeable
         for shares of any other class, or any series of the same or any other
         class and, if so, the terms and conditions thereof, including the date
         or dates when such shares shall be convertible into or exchangeable for
         shares of any other class, or any series of the same or any other
         class, the price or prices or the rate or rates at which shares of such
         series shall be so convertible or exchangeable, and any adjustments
         which shall be made, and the circumstances in which any such
         adjustments shall be made, in such conversion or exchange prices or
         rates;

            (f) Whether such series shall have any voting rights in addition to
         those prescribed by law and, if so, the terms and conditions of
         exercise of such voting rights;

            (g) The conditions and restrictions, if any, on the payment of
         dividends or on the making of other distributions on, or the purchase,
         redemption, or other acquisition by the Company or any subsidiary of,
         the Common Stock or of any other class (or other series of the same
         class) ranking junior to the shares of such series as to dividends or
         upon liquidation, dissolution or winding up;

            (h) The conditions and restrictions, if any, on the creation of
         indebtedness of the Company, or any subsidiary, or on the issue of any
         additional stock ranking on a parity with or prior to the shares of
         such series as to dividends or upon liquidation, dissolution or winding
         up; and

            (i) Such other powers, preferences and relative, participating,
         optional or other special rights, qualifications, limitations or
         restrictions as shall not be inconsistent with any such resolution or
         resolutions previously adopted as to shares then still outstanding or
         with the laws of the State of Delaware.

         3. CONSIDERATION FOR ISSUANCE. The authorized but unissued shares of
Common Stock and the authorized but unissued shares of Preferred Stock of the
Company may be issued for such consideration, having a value, not less than the
par value thereof (if any), as is determined from time to time by the Board of
Directors.

         4. MATTERS PERTAINING TO VOTING.

            (a) Except as otherwise determined by the provisions of this Article
         FOURTH or pursuant to authority of the Board of Directors as
         hereinbefore provided or by the General Corporation Law of the State of
         Delaware, all voting rights shall be vested exclusively in the holders
         of the outstanding shares of Common Stock and each such holder shall be
         entitled to one (1) vote per share for all purposes for such share of
         Common Stock held of record by him.

            (b) Except as otherwise determined pursuant to authority of the
         Board of Directors as hereinbefore provided, or by the General
         Corporation Law of the State of Delaware, the holders of shares of
         Preferred Stock shall not be entitled to vote for any purpose nor shall
         they be entitled to notice of meetings of stockholders.


                                       18
<PAGE>

         FIFTH. The corporation is to have perpetual existence.

         SIXTH. Election of directors need not be by written ballot unless the
by-laws of the corporation shall so provide.

         SEVENTH. The corporation shall, to the fullest extent permitted by
Section 145 of the General Corporation Law of the State of Delaware, as that
section may be amended and supplemented from time to time, indemnify any and all
persons whom it shall have power to indemnify under that section against any
expenses, liabilities or other matters referred to in or covered by that
section. The indemnification provided for herein shall not be deemed exclusive
of any other rights to which those seeking indemnification may be entitled under
any by-law, agreement, vote of stockholders or disinterested directors or
otherwise, both as to action in their official capacities and as to action in
another capacity while holding such office, and shall continue as to a person
who has ceased to be a director, officer, employee or agent and shall inure to
the benefit of the heirs, executors and administrators of such a person.

         EIGHTH. A director of the corporation shall not be personally liable to
the corporation or its stockholders for monetary damages for breach of fiduciary
duty as a director, except for liability (i) for any breach of the director's
duty of loyalty to the corporation or its stockholders, (ii) for acts or
omissions not in good faith or which involve intentional misconduct or a knowing
violation of law, (iii) under Section 174 of the General Corporation Law of the
State of Delaware or (iv) for any transaction from which the director derived an
improper personal benefit.

         The foregoing provisions of this Article EIGHTH shall not eliminate the
liability of a director for any act or omission occurring prior to the date on
which this Article EIGHTH becomes effective.

         If the General Corporation Law of the State of Delaware is amended
after approval of this Article EIGHTH by the stockholders to authorize the
further elimination or limitation of the liability of directors, then the
liability of directors shall be eliminated or limited to the full extent
authorized by the General Corporation Law of the State of Delaware, as so
amended.

         Any repeal or modification of this Article EIGHTH shall not adversely
affect any right or protection of a director of the corporation existing at the
time of such repeal or modification.

         NINTH. The corporation reserves the right to amend, alter, change or
repeal any provision contained in this Certificate of Incorporation, in the
manner now or hereafter prescribed by statute, and all rights conferred upon
stockholders herein are granted subject to this reservation

         TENTH. This Restated Certificate of Incorporation has been duly adopted
by the Board of Directors of the corporation in accordance with the provisions
of Section 245 of the Delaware General Corporation Law. This Restated
Certificate of Incorporation only restates and integrates, and does not further
amend, the provisions of the corporation's Certificate of Incorporation as
heretofore amended or supplemented, and there is no discrepancy between those
provisions and the provisions of this Restated Certificate of Incorporation.

         Signed this 30th day of June, 1992.


                                        /s/ Sandford D. Smith
                                        --------------------------------------
                                         Sandford D. Smith,
Attest:                                  President and Chief Executive Officer
/s/ Ramesh L. Ratan
- -------------------------------
Ramesh L. Ratan
Senior Vice President,
Administration, Chief
Financial Officer and Secretary


                                       19
<PAGE>

                            CERTIFICATE OF AMENDMENT

                                       OF

                          CERTIFICATE OF INCORPORATION

         Repligen Corporation, a corporation organized and existing under and by
virtue of the General Corporation Law of the State of Delaware ("DGCL"), DOES
HEREBY CERTIFY pursuant to Section 242 of the DGCL:

         FIRST: That the Board of Directors of Repligen Corporation (the
"Corporation"), by unanimous written consent dated June 21, 1999 in accordance
with the provisions of Sections 141(f) and 242 of the DGCL, duly and validly
adopted the following resolutions:

RESOLVED:     To amend, restate or amend and restate the Certificate of
              Incorporation to allow the Company the authority to issue
              forty-five million (45,000,000) shares of capital stock, of which
              forty million (40,000,000) shares shall constitute Common Stock
              ("Common Stock"), each share having a par value of one cent, and
              five million (5,000,000) shares shall constitute Preferred Stock
              ("Preferred Stock"), each such share having a par value of one
              cent.

RESOLVED:     That the Board of Directors deems the proposal set forth
              immediately above advisable and in the best interest of the
              Corporation and its stockholders; and that the approval of such
              proposal be recommended to the stockholders for approval at the
              Annual Meeting of Stockholders of the Corporation.

RESOLVED:     That the officers of the Corporation hereby are and each of them
              hereby is authorized to execute all such instruments, make all
              such payments and do all such other acts and things as in their
              opinion, or in the opinion of any of them, may be necessary or
              appropriate in order to carry out the intent and purposes of the
              foregoing resolutions.

         SECOND: That the stockholders of the Corporation duly adopted such
resolutions stated immediately above and approved of the amendment to the
Certificate of Incorporation of the Corporation by a vote of the stockholders of
the Corporation at the Annual Meeting of Stockholders held on September 16,
1999, in accordance with the provisions of Section 242 of the DGCL.

         THIRD: That the aforesaid amendment was duly adopted by such written
consent of the Board of Directors of the Corporation and by a vote of the
stockholders of the Corporation in accordance with the applicable provisions of
Section 242 of the DGCL, and the first paragraph of Article Fourth of the
Certificate of Incorporation is hereby deleted in its entirety and replaced in
its entirety to read as follows:

 "FOURTH. The total number of shares of stock which the Company shall have
 authority to issue is forty-five million (45,000,000), of which forty million
 (40,000,000) shares shall constitute Common Stock ("Common Stock"), each such
 share having a par value of one cent, and five million (5,000,000) shares shall
 constitute Preferred Stock ("Preferred Stock"), each such share having a par
 value of one cent."


                [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]


                                       20
<PAGE>


         IN WITNESS WHEREOF, said Repligen Corporation has caused this
certificate to be executed by Walter C. Herlihy, its President and Chief
Executive Officer, and attested to by Barbara Burnim-Day, its Director of
Finance, on this 17th day of September, 1999.

                                REPLIGEN CORPORATION


                                By:  /s/ Walter C. Herlihy
                                     -------------------------------------
                                     Walter C. Herlihy
                                     President and Chief Executive Officer

ATTEST:


By:   /s/ Barbara Burnim Day
      ----------------------
      Barbara Burnim Day
      Director of Finance


                                       21

<PAGE>


4.1 FORM OF COMMON STOCK PURCHASE WARRANT

THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS, AND MAY NOT BE SOLD OR
TRANSFERRED UNLESS SUCH SALE OR TRANSFER IS IN ACCORDANCE WITH THE REGISTRATION
REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS OR SOME OTHER EXEMPTION FROM THE
REGISTRATION REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS IS AVAILABLE WITH
RESPECT THERETO.


                          COMMON STOCK PURCHASE WARRANT

Warrant No.                                       Number of Shares:
           --------                                                --------

                              REPLIGEN CORPORATION


                            Void after July 15, 2004



         1. ISSUANCE. This Warrant is issued to ________ on this 15th day of
July, 1999 (the "Original Issue Date") by RepliGen Corporation, a Delaware
corporation (hereinafter with its successors called the "Company"), pursuant to
a certain Financial Advisory Agreement dated as of July 15, 1999 by and between
Paramount, the Company.

         2. PURCHASE PRICE; NUMBER OF SHARES. Subject to the terms and
conditions hereinafter set forth, the registered holder of this Warrant (the
"Holder"), commencing on the date hereof, is entitled upon surrender of this
Warrant with the subscription form annexed hereto duly executed, at the office
of the Company, 117 Fourth Avenue, Needham, MA 02494, or such other office as
the Company shall notify the Holder of in writing, to purchase from the Company
at a price per share of $2.75 (the "Purchase Price"), _____________ fully paid
and nonassessable shares of Common Stock, $.01 par value per share, of the
Company (the "Common Stock"). Until such time as this Warrant is exercised in
full or expires, the Purchase Price and the securities issuable upon exercise of
this Warrant are subject to adjustment as hereinafter provided.

         3. PAYMENT OF PURCHASE PRICE. The Purchase Price may be paid (i) in
cash or by check, (ii) by the surrender by the Holder to the Company of any
promissory notes or other obligations issued by the Company, with all such notes
and obligations so surrendered being credited against the Purchase Price in an
amount equal to the principal amount thereof plus accrued interest to the date
of surrender, (iii) through delivery by the Holder to the Company of other
securities issued by the Company, with such securities being credited against
the Purchase Price in an amount equal to the fair market value thereof, as
determined in good faith by the Board of Directors of the Company (the "Board"),
or (iv) by any combination of the foregoing. The Board shall promptly respond in
writing to an inquiry by the Holder as to the fair market value of any
securities the Holder may wish to deliver to the Company pursuant to clause
(iii) above.

         4. NET ISSUE ELECTION. The Holder may elect to receive, without the
payment by the Holder of any additional consideration, shares equal to the value
of this Warrant or any portion hereof by the surrender of this Warrant or such
portion to the Company, with the net issue election notice annexed hereto duly
executed, at the office of the Company. Thereupon, the Company shall issue to
the Holder such number of fully paid and nonassessable shares of Common Stock as
is computed using the following formula:

                                   X = Y (A-B)
                                        A

where


                                       22
<PAGE>


                           X = the number of shares to be issued to the Holder
pursuant to this Section 4.

                           Y = the number of shares covered by this Warrant in
                  respect of which the net issue election is made pursuant to
                  this Section 4.

                           A = the fair market value of one share of Common
                  Stock, which shall be equal to the average closing price on
                  the Nasdaq National Market of the Common Stock over the ten
                  (10) day period prior to the date the net issue election is
                  made pursuant to this Section 4.

                           B = the Purchase Price in effect under this Warrant
                  at the time the net issue election is made pursuant to this
                  Section 4.

The Board shall promptly respond in writing to an inquiry by the Holder as to
the fair market value of one share of Common Stock.

         5. PARTIAL EXERCISE. This Warrant may be exercised in part, and the
Holder shall be entitled to receive a new warrant, which shall be dated as of
the date of this Warrant, covering the number of shares in respect of which this
Warrant shall not have been exercised.

         6. ISSUANCE DATE. The person or persons in whose name or names any
certificate representing shares of Common Stock is issued hereunder shall be
deemed to have become the holder of record of the shares represented thereby as
at the close of business on the date this Warrant is exercised with respect to
such shares, whether or not the transfer books of the Company shall be closed.

         7. EXPIRATION DATE. This Warrant shall expire at the close of business
on July 15, 2004, and shall be void thereafter.

         8. RESERVED SHARES; VALID ISSUANCE. The Company covenants that it will
at all times from and after the date hereof reserve and keep available such
number of its authorized shares of Common Stock, free from all preemptive or
similar rights therein, as will be sufficient to permit the exercise of this
Warrant in full. The Company further covenants that such shares as may be issued
pursuant to the exercise of this Warrant will, upon issuance, be duly and
validly issued, fully paid and nonassessable and free from all taxes, liens and
charges with respect to the issuance thereof other than those caused or suffered
by the Holder hereof.

         9. DIVIDENDS. If after the Original Issue Date the Company shall
subdivide the Common Stock, by split-up or otherwise, or combine the Common
Stock, or issue additional shares of Common Stock in payment of a stock dividend
on the Common Stock, the number of shares issuable on the exercise of this
Warrant shall forthwith be proportionately increased in the case of a
subdivision or stock dividend, or proportionately decreased in the case of a
combination, and the Purchase Price shall forthwith be proportionately decreased
in the case of a subdivision or stock dividend, or proportionately increased in
the case of a combination.

         10. MERGERS AND RECLASSIFICATIONS. If after the Original Issue Date
there shall be any reclassification, capital reorganization or change of the
Common Stock (other than as a result of a subdivision, combination or stock
dividend provided for in Section 9 hereof), or any consolidation of the Company
with, or merger of the Company into, another corporation or other business
organization (other than a consolidation or merger in which the Company is the
continuing corporation and which does not result in any reclassification or
change of the outstanding Common Stock), or any sale or conveyance to another
corporation or other business organization of all or substantially all of the
assets of the Company, then, as a condition of such reclassification,
reorganization, change, consolidation, merger, sale or conveyance, lawful
provisions shall be made, and duly executed documents evidencing the same from
the Company or its successor shall be delivered to the Holder, so that the
Holder shall thereafter have the right to purchase, at a total price not to
exceed that payable upon the exercise of this Warrant in full, the kind and
amount of shares of stock and other securities and property receivable upon such
reclassification, reorganization, change, consolidation, merger, sale or
conveyance by a holder of the number of shares of Common Stock which might have
been purchased by the Holder immediately prior to such reclassification,
reorganization, change,


                                       23
<PAGE>


consolidation, merger, sale or conveyance, and in any such case appropriate
provisions shall be made with respect to the rights and interest of the Holder
to the end that the provisions hereof (including without limitation, provisions
for the adjustment of the Purchase Price and the number of shares issuable
hereunder) shall thereafter be applicable in relation to any shares of stock or
other securities and property thereafter deliverable upon exercise hereof.

         11. FRACTIONAL SHARES. In no event shall any fractional share of Common
Stock be issued upon any exercise of this Warrant. If, upon exercise of this
Warrant as an entirety, the Holder would, except as provided in this Section 11,
be entitled to receive a fractional share of Common Stock, then the Company
shall issue the next higher number of full shares of Common Stock, issuing a
full share with respect to such fractional share.

         12. CERTIFICATE OF ADJUSTMENT. Whenever the Purchase Price is adjusted,
as herein provided, the Company shall promptly deliver to the Holder a
certificate of a firm of independent public accountants setting forth the
Purchase Price after such adjustment and setting forth a brief statement of the
facts requiring such adjustment.

         13. NOTICES OF RECORD DATE, ETC. In the event of:

                  (a) any taking by the Company of a record of the holders of
any class of securities for the purpose of determining the holders thereof who
are entitled to receive any dividend or other distribution, or any right to
subscribe for, purchase or otherwise acquire any shares of stock of any class or
any other securities or property, or to receive any other right,

                  (b) any reclassification of the capital stock of the Company,
capital reorganization of the Company, consolidation or merger involving the
Company, or sale or conveyance of all or substantially all of its assets, or

                  (c) any voluntary or involuntary dissolution, liquidation or
winding-up of the Company, then and in each such event the Company will mail
or cause to be mailed to the Holder a notice specifying (i) the date on
which any such record is to be taken for the purpose of such dividend,
distribution or right, and stating the amount and character of such dividend,
distribution or right, or (ii) the date on which any such reclassification,
reorganization, consolidation, merger, sale or conveyance, dissolution,
liquidation or winding-up is to take place, and the time, if any is to be
fixed, as of which the holders of record in respect of such event are to be
determined. Such notice shall be mailed at least twenty (20) days prior to the
date specified in such notice on which any such action is to be taken.

         14. AMENDMENT. The terms of this Warrant may be amended, modified or
waived only with the written consent of the Company and the Holder hereof.

         15. WARRANT  REGISTER; TRANSFERS, ETC.

             A. The Company will maintain a register containing the names and
addresses of the registered holders of the Warrant. The Holder may change its
address as shown on the warrant register by written notice to the Company
requesting such change. Any notice or written communication required or
permitted to be given to the Holder may be given by certified mail or delivered
to the Holder at its address as shown on the warrant register.

             B. Subject to compliance with applicable federal and state
securities laws, this Warrant may be transferred by the Holder with respect to
any or all of the shares purchasable hereunder. Upon surrender of this Warrant
to the Company, together with the assignment hereof properly endorsed, for
transfer of this Warrant as an entirety by the Holder, the Company shall issue a
new warrant of the same denomination to the assignee. Upon surrender of this
Warrant to the Company, together with the assignment hereof properly endorsed,
by the Holder for transfer with respect to a portion of the shares of Common
Stock purchasable hereunder, the Company shall issue a new warrant to the
assignee, in such denomination as shall be requested


                                       24
<PAGE>


by the Holder hereof, and shall issue to such Holder a new warrant covering the
number of shares in respect of which this Warrant shall not have been
transferred.

             C. In case this Warrant shall be mutilated, lost, stolen or
destroyed, the Company shall issue a new warrant of like tenor and denomination
and deliver the same (i) in exchange and substitution for and upon surrender and
cancellation of any mutilated Warrant, or (ii) in lieu of any Warrant lost,
stolen or destroyed, upon receipt of evidence reasonably satisfactory to the
Company of the loss, theft or destruction of such Warrant (including a
reasonably detailed affidavit with respect to the circumstances of any loss,
theft or destruction) and of indemnity reasonably satisfactory to the Company.

         16. CERTAIN OBLIGATIONS. This Warrant has been issued subject to
certain obligations to register the Common Stock under the Securities Act of
1933, as amended, which obligations are set forth in the Agreement, of even date
herewith, between the Company, and Paramount, which are incorporated herein by
reference.

         17. NO IMPAIRMENT. The Company will not, by amendment of its
certificate of incorporation, as amended or through any reclassification,
capital reorganization, consolidation, merger, sale or conveyance of assets,
dissolution, liquidation, issue or sale of securities or any other voluntary
action, avoid or seek to avoid the observance or performance of any of the terms
of this Warrant, but will at all times in good faith assist in the carrying out
of all such terms and in the taking of all such action as may be necessary or
appropriate in order to protect the rights of the Holder.

         18. GOVERNING LAW. The provisions and terms of this Warrant shall be
governed by and construed in accordance with the internal laws of the
Commonwealth of Massachusetts.

         19. SUCCESSORS AND ASSIGNS. This Warrant shall be binding upon the
Company's successors and assigns and shall inure to the benefit of the Holder's
successors, legal representatives and permitted assigns.

         20. BUSINESS DAYS. If the last or appointed day for the taking of any
action required or the expiration of any right granted herein shall be a
Saturday or Sunday or a legal holiday in the Commonwealth of Massachusetts, then
such action may be taken or right may be exercised on the next succeeding day
which is not a Saturday or Sunday or such a legal holiday.

Dated:    July 15, 1999                              REPLIGEN CORPORATION



(Corporate Seal)                             By:    /s/ Walter C. Herlihy
                                                    -----------------------
                                                Name:     Walter Herlihy
Attest: /s/  Barbara Burnim Day                 Title:    President and CEO
- -------------------------------
Director of Finance


                                       25
<PAGE>


                                         Subscription


To:                                      Date:
   ----------------------                     ----------------------------


         The undersigned hereby subscribes for __________ shares of Common Stock
covered by this Warrant. The certificate(s) for such shares shall be issued in
the name of the undersigned or as otherwise indicated below:


                                         ---------------------------------
                                         Signature



                                         ---------------------------------
                                         Name for Registration


                                         ---------------------------------
                                         Mailing Address



                                         Net Issue Election Notice


To:                                      Date:
   ----------------------                     ----------------------------

         The undersigned hereby elects under Section 4 to surrender the right to
purchase _______ shares of Common Stock pursuant to this Warrant. The
certificate(s) for the shares issuable upon such net issue election shall be
issued in the name of the undersigned or as otherwise indicated below.



                                         ---------------------------------
                                         Signature


                                         ---------------------------------
                                         Name for Registration


                                         ---------------------------------
                                         Mailing Address



                                       26
<PAGE>


                                   Assignment


       For value received                             hereby sells, assigns and
                         ----------------------------

transfers unto
              ----------------------------------------

- -----------------------------------------------------------------
    Please print or typewrite name and address of Assignee

- -----------------------------------------------------------------

the within Warrant, and does hereby irrevocably constitute and appoint
_______________________ its attorney to transfer the within Warrant on the books
of the within named Company with full power of substitution on the premises.

Dated:
      --------------------------



In the Presence of:


- -----------------------------



                                       27

<PAGE>



10.1 FINANCIAL ADVISORY AGREEMENT

                                                   July 15, 1999




Walter C. Herlihy, Ph.D.
Chief Executive Officer
Repligen Corporation
117 Fourth Avenue
Needham, MA 02494


                  RE:      FINANCIAL ADVISORY AGREEMENT

Dear Sirs:

                  This is to confirm our agreement that Paramount Capital, Inc.,
its affiliates, related entities and designees (collectively, "Paramount") have
been engaged as a non-exclusive financial advisor of Repligen Corporation (the
"Company") for a period of twelve (12) months from the date hereof (the "Term").
During the Term, Paramount will assist the Company in (a) the placement of
shares of common stock, $.01 par value per share (the "Common Stock"), of the
Company, as such shares may become available for sale (other than an aggregate
of 3,600,000 shares of Common Stock being issued and sold pursuant to the Stock
Purchase Agreements dated as of April 30, 1999 and May 14, 1999 by and among the
Company and the parties thereto (the "Stock Purchase Agreements")) and (b) the
acquisition of or the structuring of a business relationship with CRC, Inc., any
subsidiary, parent entity or affiliate thereto ("CRC") as set forth below. The
terms of our agreement are set forth in more detail below.

                  Section 1. EXPENSES. The Company shall be responsible for, and
shall bear all reasonable expenses relating to this Agreement, including all
reasonable expenses incurred by Paramount (including the reasonable fees and
expenses of any outside legal counsel employed by Paramount) in connection
herewith, such expenses to be paid within fifteen (15) days of receipt by the
Company of a bill or bills by Paramount from time to time; PROVIDED THAT in no
event shall the Company pay more than an aggregate of $5,000 for such fees or
expenses. In the event that the fees and expenses incurred by Paramount exceed
$5,000, the Company and Paramount may mutually agree upon additional payment
obligations of the parties with respect thereto.

                  Section 2. TRANSACTION FEES.

         (a) Within 30 days of the execution of this Agreement, the Company
shall pay each to Paramount a cash fee (a "Cash Fee") equal to $100,000 and
shall issue to Paramount warrants, substantially in the form attached hereto as
EXHIBIT A (the "Warrants"), to purchase an aggregate of 100,000 shares of Common
Stock of the Company at an exercise price equal to $2.75 per share. Such
Warrants shall be exercisable at any time until five years from the date of
issuance of such Warrants.

         (b) During the Term, and for a period of 12 months thereafter, the
Company shall pay to Paramount a fee in cash and/or equity, in an amount to be
agreed upon between the Company and Paramount, as a result of any Investment (as
defined below) by an investor deemed to be a Paramount Client (as defined below)
hereunder. For the purposes of this Agreement, an "Investment" shall mean any
purchase of equity securities of the Company directly from the Company by a
Paramount Client (but specifically excluding the purchase of an aggregate of
3,600,000 shares of Common Stock of the Company by those certain parties to the
Stock Purchase Agreements) during the Term or during the 12-month period
following the expiration of the Term. For purposes of this Agreement, an
investor shall be considered a "Paramount Client" only if, during the Term, (i)
Paramount has introduced the investor to the Company and has identified in
writing such investor to


                                       28
<PAGE>


the Company and (ii) Paramount has had substantive discussions with such
investor regarding an Investment. For the avoidance of doubt, at the time of
termination of this Agreement, Paramount shall have 30 days following such
termination to provide to the Company with a list of all prospective Paramount
Clients for whom Paramount would be eligible to receive a fee hereunder for an
Investment.

         (c) Should the Company enter into an agreement with CRC during the
Term, or during the 12-month period following the expiration of such Term,
pursuant to which the Company consummates a sale, merger, consolidation, tender
offer, business combination, joint venture or partnership, pursuant to which,
the Company or the shareholders of the Company acquire more than 50% of the
outstanding capital stock and voting control of CRC, then the Company shall pay
Paramount a fee equal to five percent (5%) of the aggregate consideration
actually paid (net of the aggregate exercise or conversion price of all
unexercised options, warrants or other convertible securities assumed by the
acquiring company and all related CRC Transaction Fees and expenses) at the
closing (the "CRC Transaction Fee") of such transaction to or by the Company or
its shareholders. The Company shall use reasonable commercial efforts to pay
such CRC Transaction Fee to Paramount at the closing in the form of
consideration and allocation of the types of consideration (i.e., cash or stock)
substantially similar to that paid by or to the Company or the Company's
shareholders; PROVIDED THAT if the form and allocation of the CRC Transaction
Fee payable to Paramount shall, in the Company's determination, cause the
Company or its shareholders adverse tax, accounting, or legal consequences, the
Company shall be permitted to pay the CRC Transaction Fee to Paramount in the
form and allocation which minimizes or removes such adverse tax, accounting or
legal consequences. For purposes of calculating Paramount's CRC Transaction Fee
under this Section 3, aggregate consideration shall include only those payments
made at the closing of such transaction whether in cash, stock or warrants, and
(ii) future milestone payments made to CRC or its employees in connection with
the closing of such transaction. The Cash Fee described in Section 2(a) above
shall be creditable in full against any fee payable pursuant to this Section
2(c).

         Section 3. REGISTRATION RIGHTS.

         (a) Subject to the terms herein, if at any time the Company shall
determine to register for its own account or the account of others under the
Securities Act of 1933 (the "Securities Act") any of its equity securities, it
shall send to Paramount, as a holder of Registrable Shares (as defined below),
written notice of such determination and, if within fifteen (15) days after
receipt of such notice, such holder shall so request in writing that the Company
include all (but not less than all) of the Registrable Shares, the Company shall
include, subject to the terms herein, in such registration statement all (but
not less than all) the Registrable Shares such holder requests to be registered.
Notwithstanding anything to the contrary herein, if, in connection with any
offering involving an underwriting of Common Stock to be issued by the Company,
the managing underwriter shall impose a limitation on the number of shares of
such Common Stock which may be included in the registration statement because,
in its judgment, such limitation is necessary to effect an orderly public
distribution, then the Company shall be obligated to include in such
registration statement only such limited portion of the Registrable Shares as
the managing underwriter, in its own discretion, shall determine. For purposes
of this Section 3, the term "Registrable Shares" shall mean the shares of Common
Stock issuable upon exercise of a Warrant.

         (b) This Section 3 shall not apply to a registration of shares of
Common Stock on Form S-8 or Form S-4 or their then equivalents relating to an
offering of shares of Common Stock to be issued solely in connection with any
acquisition of any entity or business or otherwise issuable in connection with
any stock option, stock purchase or employee benefit plan. Further, this Section
3 shall not apply to the registration of shares of Common Stock of the Company
issued and sold pursuant to the Stock Purchase Agreements and that certain
Patent Purchase Agreement dated as of March 9, 1999 by and among the Company and
the parties thereto. This Section 3 shall expressly exclude the registration
statements covering the resale of such shares and any and all amendments and/or
supplements thereto.

         (c) Notwithstanding anything to the contrary herein, if the Company has
not filed a registration statement to register the resale of all of the
Registrable Shares under Section 3(a) herein by the date nine months from the
date hereof, holders of the Registrable Shares constituting all of the
Registrable Shares then outstanding may request that the Company file a
registration statement on Form S-3 or any successor


                                       29
<PAGE>


thereto for a public offering of all (but not less than all) of the Registrable
Shares then held by such requesting holder or holders; PROVIDED THAT the
reasonably anticipated aggregate price to the public of such registrable shares
would exceed $100,000 and the Company is a registrant entitled to use Form S-3
or any successor thereto to register such shares (the "Registration Request").
Within 30 days of a Registration Request made in accordance with the terms
above, the Company shall use its best efforts to register under the Securities
Act on Form S-3 or any successor thereto, for public sale in accordance with the
method of disposition specified in such notice, the number of Registrable Shares
specified in such notice.

         (d) In the case of a registration effected under Section 3, the Company
shall bear the reasonable costs and expenses of such registration on behalf of
Paramount with respect to the resale of its Registrable Shares (except as
otherwise prohibited by state securities law or regulation), which shall include
the Company's printing, legal and accounting fees and expenses, the Securities
and Exchange Commission and National Association of Securities Dealers, Inc.
("NASD") filing fees and "blue sky" fees and expenses; PROVIDED HOWEVER, that
the Company shall have no obligation to pay or otherwise bear any portion of the
underwriters' commissions or discounts attributable to the Registrable Shares
being offered and sold by the holders of Registrable Shares, or the fees and
expenses of any counsel engaged by Paramount in connection with the registration
of the Registrable Shares.

                  Section 4. FINANCIAL INFORMATION. The Company shall provide
Paramount with all financial and other information reasonably requested by
Paramount for the purposes of rendering its services pursuant to this Agreement,
and all such information shall be deemed to be "Confidential Information" (as
defined herein), subject to the terms of Section 5 herein.

                  Section 5. CONFIDENTIAL INFORMATION.

         (a) Confidential Information shall mean any information disclosed by
one party to the other party hereunder (in writing, if marked by the disclosing
party as confidential, or verbally, if notified by the disclosing party as
confidential), including, without limitation, the terms of this Agreement, all
commercially valuable, proprietary or confidential information with respect to
the Company's business, products or operations disclosed by the Company to
Paramount, which includes financial information, marketing plans, strategies and
other valuable business information. Confidential Information shall also include
any financial advice provided hereunder by Paramount to the Company.
Notwithstanding anything to the contrary in this Section 5, Confidential
Information shall not include: (i) information that is in or enters the public
domain without breach of this Agreement; (ii) information lawfully received from
a third party without restriction on disclosure and without breach of a
nondisclosure obligation; (iii) information that is developed independently by a
party which party can prove such independent development with written evidence;
and (iv) information that is required by judicial or administrative order or by
governmental authority to be disclosed, provided that the party from whom
disclosure is sought uses reasonable efforts to notify the other of such
requirement so that the other may seek to make such disclosure subject to a
protective order or confidentiality agreement.

         (b) The Company agrees to limit disclosure of the Confidential
Information only to those of its officers, employees, agents, affiliates and
consultants as the Company considers necessary, provided that each such officer,
employee, agent, affiliate or consultant of the Company shall be similarly bound
by the confidentiality obligations contained herein. The Company shall take all
reasonable commercial steps to prevent the disclosure of the Confidential
Information as it would to protect its own confidential or proprietary
information. This obligation shall be binding upon the Company and shall
continue for a period during the term of this Agreement and for a period of five
(5) years thereafter.

         (c) Paramount agrees to limit disclosure of the Confidential
Information only to those of its officers, employees, agents, affiliates and
consultants as Paramount considers necessary to render its services under this
Agreement, provided that each such officer, employee, agent, affiliate or
consultant of Paramount shall be similarly bound by the confidentiality
obligations contained herein. Paramount shall take all reasonable commercial
steps to prevent the disclosure of the Confidential Information as it would to
protect its own confidential or proprietary information. Paramount understands
and agrees that to the extent Paramount receives Confidential Information which
is material and non-public relating to the Company, Paramount shall be deemed to
be an "insider" for purposes of United States securities laws and shall be
prohibited from


                                       30
<PAGE>


selling, purchasing or otherwise trading in the securities of the Company until
public disclosure of such material non-public information. Paramount may rely,
without independent verification, on the accuracy and completeness of any
written information furnished to Paramount by the Company, subject to its
obligations under the securities laws and herein. This obligation shall be
binding upon Paramount and shall continue for a period during the term of this
Agreement and for a period of five (5) years thereafter.



                  Section 6. INDEMNIFICATION.

         (a) The Company agrees to indemnify and hold harmless Paramount and its
respective partners, shareholders, directors, officers, agents, advisors,
representatives, employees, counsel and controlling persons within the meaning
of the Securities Act (a "Paramount Indemnified Party") against any and all
losses, liabilities, claims, damages and expenses whatsoever (and all actions in
respect thereof), and to promptly reimburse any such Paramount Indemnified Party
for the reasonable legal fees and related expenses as incurred (including, but
not limited to the costs of giving testimony or furnishing documents in response
to a document request, a subpoena or otherwise, the costs of investigating,
preparing, pursuing or defending any such action or claim whether or not pending
or threatened and whether or not any Paramount Indemnified Party is a party
thereto), insofar as such losses, liabilities, claims, damages or expenses arise
out of, relate to, are in incurred in connection with or are in any way a result
of or relate to this Agreement or the matters contemplated by this Agreement;
PROVIDED HOWEVER that the Company shall not be liable to a Paramount Indemnified
Party hereunder to the extent that any loss, claim, damage, liability or expense
is found in final judgement by a court or arbitrator to have resulted from a
Paramount Indemnified Party's fraud, bad faith or gross negligence; and PROVIDED
FURTHER that in no event shall the Company's liability under this Section 6
exceed the aggregate amount of fees paid by the Company to Paramount hereunder.

         (b) Paramount agrees to indemnify and hold harmless the Company and its
respective partners, shareholders, directors, officers, agents, advisors,
representatives, employees, counsel and controlling persons within the meaning
of the Securities Act (a "Company Indemnified Party") against any and all
losses, liabilities, claims, damages and expenses whatsoever (and all actions in
respect thereof), and to promptly reimburse any such Company Indemnified Party
for reasonable legal fees and related expenses as incurred (including, but not
limited to the costs of giving testimony or furnishing documents in response to
a document request, a subpoena or otherwise, the costs of investigating,
preparing, pursuing or defending any such action or claim whether or not pending
or threatened and whether or not any Paramount Indemnified Party is a party
thereto), insofar as such losses, liabilities, claims, damages or expenses arise
out of, relate to, are in incurred in connection with or are in any way a result
of or relate to Paramount's fraud, bad faith or gross negligence in the
performance of the services pursuant to this Agreement; PROVIDED HOWEVER that
Paramount shall not be liable hereunder to the extent that any loss, claim,
damage, liability or expense is found in final judgement by a court or
arbitrator to have resulted from a Company Indemnified Party's fraud, bad faith
or gross negligence.

         (c) The indemnification provisions of this Section 6 shall be the sole
and exclusive remedies of the parties hereto with respect to any claims arising
hereunder by one party against the other party hereunder, except that any claim
by one party against the other party under this Agreement for an intentional and
material breach of Section 5 hereunder or a claim based on fraud, bad faith or
gross negligence shall not be limited to the remedies and limitations of this
Section 6.

                  Section 7. TERMINATION; SURVIVAL. The Company shall be
entitled to terminate this Agreement at any time by providing 10 days' notice to
Paramount. The provisions of Sections 1, 2, 3, 5, 6, 8, 9, 10, 11, 12 and 13
shall survive termination of this Agreement. Paramount shall be entitled to the
reimbursement of reasonable expenses incurred by Paramount as a result of
services rendered prior to the date of the termination.


                                       31
<PAGE>

                  Section 8. GOVERNING LAW. This Agreement shall be governed by
and construed in accordance with the laws of the Commonwealth of Massachusetts
without regard to principles of conflicts of law.

                  Section 9. NON-COMPETE.

         (a) Paramount shall not be in any way precluded from (i) entering into
similar agreements with companies which engage in similar business activities or
lines of business as the Company or developing or marketing any products,
services or technologies that do or may in the future compete, directly or
indirectly, with those of the Company, (ii) investing or owning any interest
publicly or privately in, or developing a business relationship with, any
corporation, partnership or other person or entity engaged in the same or
similar activities or lines or business as, or otherwise in competition with,
the Company or (iii) doing business with any client, collaborator, licensor,
consultant, vendor or customer of the Company. Paramount and any of its
officers, directors, employees or former employees and affiliates shall not have
any obligation, or be liable, to the Company solely on account of the conduct
described in the preceding sentence. The Company recognizes that Paramount is
not obligated to present any opportunities for an investment, sale, acquisition,
strategic alliance or any other opportunities to the Company and nothing in this
Agreement shall be construed to limit Paramount's ability to introduce
investment, sale, acquisition, strategic alliance or any other opportunities to
any other company. In the event that Paramount and/or any officer, director,
employee or former employee or affiliate thereof acquires knowledge of a
potential transaction, agreement, arrangement or other matter which may be a
corporate opportunity for both Paramount and the Company, neither Paramount nor
any of its officers, directors, employees or former employees or affiliates
shall have any duty to communicate or offer such corporate opportunity to the
Company and neither Paramount nor any of its officers, directors, employees or
former employees or affiliates shall be liable to the Company for breach of any
fiduciary or other duty, as a stockholder or otherwise, solely by reason of the
fact that Paramount or any of its officers, directors, employees or former
employees or affiliates pursue or acquire such corporate opportunity for
Paramount, direct such corporate opportunity to another person or entity or
communicate or fail to communicate such corporate opportunity or entity to the
Company. Nothing in this Section 9 shall relieve Paramount of its obligations
hereunder, including Section 5 hereunder.

         (b) Notwithstanding anything to the contrary herein, unless the Company
consents in writing, at no time during the Term or at any time with 12 months
after the Term shall Paramount be engaged by any entity, other than the Company,
in order to provide advisory services or any other types of services in
connection with structuring of any type of business relationship or transaction
involving CRC (including, without limitation, the sale or merger of CRC or the
sale of equity or other securities of any kind in CRC).

                  Section 10. ANNOUNCEMENT OF TRANSACTION. Except as otherwise
required by law, neither party shall make any public announcement regarding any
of the transactions contemplated in this Agreement without obtaining the prior
written consent of the other party, which consent shall not be unreasonably
withheld.

                 Section 11. WRITING REQUIRED TO WAIVE, AMEND OR MODIFY. No
waiver, amendment or other modification of this Agreement shall be effective
unless in writing and signed by each party hereto.

                  Section 12. PARTIES. This Agreement incorporates the entire
understanding of the parties with respect to this engagement of Paramount by the
Company, and supersedes all previous agreements regarding such engagement,
should they exist.

                  Section 13. NOTICES. All communications hereunder shall be in
writing and shall be deemed given, if delivered in person, by telecopy or mail
to: (a) the Company, 117 Fourth Avenue, Needham, MA 02494, Attention: Walter C.
Herlihy (Telecopy: (781) 453-0048) and (b) to Paramount, at its offices at 787
Seventh Avenue, New York, NY 10019, Attention: David M. Tanen (Telecopy: (212)
554-4355).


                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]


                                       32
<PAGE>


         Please confirm that the foregoing is in accordance with your
     understanding by signing and returning to us the enclosed duplicate of this
     letter.


                                             Sincerely yours,

                                             PARAMOUNT CAPITAL, INC.


                                             By:  /s/ Peter M. Kash
                                                ------------------------
                                                Senior Managing Director

Confirmed as of the date hereof:

REPLIGEN CORPORATION


By:  /s/ Walter C. Herlihy
     ------------------------
     Chief Executive Officer



                                       33

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
This schedule contains financial information extracted from the financial
statements for Repligen Corporation and is qualified in its entirety by
reference to such financial statements.
</LEGEND>
<MULTIPLIER> 1,000

<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          MAR-31-2000
<PERIOD-END>                               SEP-30-1999
<CASH>                                          10,913
<SECURITIES>                                         0
<RECEIVABLES>                                      513
<ALLOWANCES>                                      (25)
<INVENTORY>                                        495
<CURRENT-ASSETS>                                12,205
<PP&E>                                           1,714
<DEPRECIATION>                                 (1,019)
<TOTAL-ASSETS>                                  12,982
<CURRENT-LIABILITIES>                              518
<BONDS>                                              0
                                0
                                          0
<COMMON>                                           219
<OTHER-SE>                                      12,245
<TOTAL-LIABILITY-AND-EQUITY>                    12,982
<SALES>                                            811
<TOTAL-REVENUES>                                 1,670
<CGS>                                              483
<TOTAL-COSTS>                                    2,898
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                   0
<INCOME-PRETAX>                                      0
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                                  0
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (1,228)
<EPS-BASIC>                                      (.06)
<EPS-DILUTED>                                    (.06)


</TABLE>


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission