REPLIGEN CORP
4, 2001-01-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

|_|   Check this box if no longer subject to Section 16. Form 4 or Form 5
      obligations may continue. See Instruction 1(b).

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1. Name and Address of Reporting Person*

   Rosenwald, Lindsay A.
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   (Last)               (First)                 (Middle)

   c/o Paramount Capital Asset Management, Inc.,
   787 Seventh Avenue, 48th Floor
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                                    (Street)

   New York               NY                    10019
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   (City)               (State)                 (Zip)

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2. Issuer Name and Ticker or Trading Symbol

   Repligen Corporation (RGEN)
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3. IRS Identification Number of Reporting Person, if an Entity (Voluntary)


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4. Statement for Month/Year

   December 2000
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5. If Amendment, Date of Original (Month/Year)


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6. Relationship of Reporting Person to Issuer
   (Check all applicable)

   |_|   Director                             |X|   10% Owner
   |_|   Officer (give title below)           |_|   Other (specify below)

================================================================================
7. Individual or Joint/Group Filing (Check Applicable Line)

   |_|  Form filed by one Reporting Person
   |X|  Form filed by more than one Reporting Person

================================================================================

* If the Form is filed by more than one Reporting Person, see Instruction
  4(b)(v).
<PAGE>

================================================================================
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                    6.
                                                      4.                             5.             Owner-
                                                      Securities Acquired (A) or     Amount of      ship
                                         3.           Disposed of (D)                Securities     Form:     7.
                                         Transaction  (Instr. 3, 4 and 5)            Beneficially   Direct    Nature of
                           2.            Code         ----------------------------   Owned at End   (D) or    Indirect
1.                         Transaction   (Instr. 8)                   (A)            of Month       Indirect  Beneficial
Title of Security          Date          ------------     Amount      or     Price   (Instr. 3      (I)       Ownership
(Instr. 3)                 (mm/dd/yy)     Code     V                  (D)            and 4)         (Instr.4) (Instr. 4)
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<S>                        <C>            <C>      <C>    <C>         <C>    <C>     <C>            <C>       <C>
                                                                                                              By The Aries Master
Common Stock               12/05/00        P               6,069       A     $4.063  4,924,200(1)    I        Fund II(1)
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                                   Page 1 of 5
<PAGE>

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                                                                                                              By The Aries Master
Common Stock               12/19/00        P               1,000       A     $4.590  4,924,200(1)    I        Fund II(1)
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                                                                                                              By The Aries Master
Common Stock               12/20/00        P              12,106       A     $3.390  4,924,200(1)    I        Fund II(1)
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                              By Aries Domestic
Common Stock               12/01/00        P               1,000       A     $4.591  4,924,200(1)    I        Fund, L.P.(1)
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                              By Aries Domestic
Common Stock               12/05/00        P               2,933       A     $4.063  4,924,200(1)             Fund, L.P.(1)
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                              By Aries Domestic
Common Stock               12/20/00        P               5,788       A     $3.390  4,924,200(1)    I        Fund, L.P.(1)
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                              By Aries Domestic
Common Stock               12/05/00        P                 998       A     $4.063  4,924,200(1)    I        Fund II, L.P.(1)
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                              By Aries Domestic
Common Stock               12/20/00        P               2,106       A     $3.390  4,924,200(1)    I        Fund II, L.P.(1)
====================================================================================================================================
</TABLE>

Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.


                                   Page 2 of 5
<PAGE>

FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
            (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                       9.        10.
                                                                                                    Number    Owner-
                                                                                                    of        ship
              2.                                                                                    Deriv-    Form of
              Conver-                    5.                              7.                         ative     Deriv-   11.
              sion                       Number of                       Title and Amount           Secur-    ative    Nature
              of                         Derivative    6.                of Underlying     8.       ities     Secur-   of
              Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-
              cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct
              Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-
1.            of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial
Title of      Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner-
Derivative    ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship
Security      Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)    ity      Year)    Code V    (A)   (D)    cisable  Date     Title     Shares  5)       4)        5)       5)
-----------------------------------------------------------------------------------------------------------------------------------
<S>           <C>      <C>      <C>  <C>  <C>   <C>    <C>      <C>      <C>       <C>     <C>      <C>       <C>      <C>
                                                                                                                       Aries
                                                                                                                       Domestic
Put (Long)    $10      12/01/00  P         10          Immed.   03/16/01  Common    1,000   $5.41    43        I       Fund, L.P.(2)
-----------------------------------------------------------------------------------------------------------------------------------

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===================================================================================================================================
</TABLE>


                                   Page 3 of 5
<PAGE>

Explanation of Responses:


**  Intentional misstatements or omissions of facts constitute Federal Criminal
    Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

(1) See Attachment A

(2) Paramount Capital Asset Management, Inc. ("PCAM") is the general partner of
each of the Aries Domestic Fund, L.P. ("Aries I") and Aries Domestic Fund II,
L.P. ("Aries II"), each a Delaware limited partnership, and also serves as the
investment manager of the Aries Master Fund II, a Cayman Island exempted company
(the "Master Fund"), which also owns securities of the Issuer. Dr. Rosenwald is
the chairman and sole stockholder of PCAM. As a result, Dr. Rosenwald and PCAM
may be deemed to have voting and investment control over the securities of the
issuer owned by the Aries Funds under Rule 16a-(a)(1) of the Securities Exchange
Act of 1934. Dr. Rosenwald and PCAM disclaim beneficial ownership of the
securities held by the Aries Funds, except to the extent of its pecuniary
interest therein, if any.


/s/ Lindsay Rosenwald                                    January 9, 2001
---------------------------------------------            -----------------------
** Signature of Reporting Person                                  Date
     Lindsay A. Rosenwald, M.D.
     Chairman
     Paramount Capital Asset Management, Inc.
     Investment Manager - Aries Master Fund II
     General Partner - Aries Domestic Fund L.P.
     General Partner - Aries Domestic Fund II, L.P.

Note: File three copies of this Form, one of which must be manually signed. If
      space provided is insufficient, see Instruction 6 for procedure.


                                   Page 4 of 5
<PAGE>

                                  ATTACHMENT A

Securities beneficially owned by Dr. Rosenwald are presented on an as-converted
basis and consist of the following:

1.    3,319,545 shares of common stock of the Issuer, par value $0.01 per share
      (the "Common Stock") owned by The Aries Master Fund, a Cayman Island
      Exempted Company (the "Master Fund")

2.    1,345,795 shares of Common Stock of the Issuer owned by Aries Domestic
      Fund, L.P. ("Aries I")

3.    225,610 shares of Common Stock owned by Aries Domestic Fund II, L.P.
      ("Aries II" and collectively with Aries I and the Master Fund, the "Aries
      Funds")

4.    Warrants to purchase 33,250 shares of Common Stock owned directly by Dr.
      Rosenwald.


                                   Page 5 of 5



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