SYNERGEN INC
POS AM, 1995-03-28
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

                                                       REGISTRATION NO. 33-41797
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                         POST-EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-4
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933


                              AMGEN BOULDER INC.
             (Exact name of registrant as specified in its charter)

                      (FORMERLY KNOWN AS SYNERGEN, INC.)

<TABLE>
           <S>                                    <C>                                   <C>
                       DELAWARE                               2831                           84-0868248
           (State or other jurisdiction of        (Primary Standard Industrial            (I.R.S. Employer
            incorporation or organization)         Classification Code Number)          Identification No.)
</TABLE>                                                                        

                                 C/O AMGEN INC.
                                  AMGEN CENTER
                             1840 DEHAVILLAND DRIVE
                          THOUSAND OAKS, CA 91320-1789
                                 (805) 447-1000
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)





<TABLE>
 <S>                                                            <C>
       MARGARET VALEUR-JENSEN, PH.D.                                     With copies to:
              SENIOR COUNSEL                                        GEORGE A. VANDEMAN, ESQ.
                AMGEN INC.                                              LATHAM & WATKINS
               AMGEN CENTER                                     633 WEST FIFTH STREET, SUITE 4000
          1840 DEHAVILLAND DRIVE                                      LOS ANGELES, CA 90071
       THOUSAND OAKS, CA  91320-1789                                     (213) 485-1234
              (805) 447-1000                               
  (Name, address, including zip code, and                  
 telephone number, including area code, of                 
            agent for service)
</TABLE>

================================================================================
<PAGE>   2
                 This Registration Statement No. 33-41797 (the "Registration
Statement") registered an aggregate of 511,500 shares of Common Stock, par
value $.01, and 930 Warrants to Purchase Common Stock exercisable into an
aggregate of 139,500 shares of Common Stock (together, the "Securities"), of
Amgen Boulder Inc. (formerly known as Synergen, Inc.) (the "Registrant").

                 On December 29, 1994, the Registrant became a wholly-owned
subsidiary of Amgen Inc. following a merger.  As a result of the merger, it is
anticipated that the Registrant's securities will no longer be registered under
the Securities Act of 1934, as amended.  Accordingly, the Registrant is
removing the Securities from registration under the Securities Act of 1933, 
as amended.





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<PAGE>   3
                                   SIGNATURE

                 Pursuant to the requirements of the Securities Act of 1933, as
amended, the Registrant has duly caused this Post-Effective Amendment No. 1 to
the Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Thousand Oaks, State of California,
on March 6, 1995.

                                       AMGEN BOULDER INC.


                                       By:  /s/  THOMAS E. WORKMAN, JR.
                                            ---------------------------------
                                            Thomas E. Workman, Jr.
                                            Vice President, Secretary
                                            and General Counsel


                               POWER OF ATTORNEY

                 Each person whose signature appears below constitutes and
appoints Thomas E. Workman, Jr. his true and lawful attorney-in-fact and agent,
with full power of substitution and resubstitution, for him and in his name,
place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) to the Registration Statement amended by
this Post-Effective Amendment No. 1, and to file the same, with all exhibits
thereto and other documents in connection therewith, with the Securities and
Exchange Commission, granting unto said attorneys-in-fact and agents, and each
of them, full power and authority to do and perform each and every act and
thing requisite and necessary to be done in and about the premises, as fully to
all intents and purposes as he might or could do in person, hereby ratifying
and confirming all that said attorneys-in-fact and agents or any of them, or
their or his substitutes or substitute, may lawfully do or cause to be done by
virtue hereof.

                 Pursuant to the requirements of the Securities Act of 1933, as
amended, this Post-Effective Amendment No. 1 to the Registration Statement has 
been signed by the following persons in the capacities and on the dates 
indicated.

<TABLE>
<CAPTION>
Signature                            Title                                      Date
- ---------                            -----                                      ----
<S>                                  <C>                                        <C>
/s/ GORDON M. BINDER
- -----------------------                                                  
Gordon M. Binder                     Chief Executive Officer                    March 13, 1995
                                     (Principal Executive Officer)        
                                                                          
/s/ ROBERT S. ATTIYEH                                                                          
- -----------------------                                                   
Robert S. Attiyeh                    Senior Vice President, Finance             March 13, 1995
                                     and Corporate Development 
                                     and Director         
                                     (Principal Financial and Accounting  
                                     Officer)
</TABLE>                         





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<PAGE>   4

<TABLE>
<S>                                   <C>                                       <C>
/s/ THOMAS E. WORKMAN, JR.
- ---------------------------                                              
Thomas E. Workman, Jr.                Vice President, Secretary,                March 6, 1995
                                      General Counsel and Director   
                                                                     
/s/ DR. N. KIRBY ALTON                                                                     
- ---------------------------                                              
Dr. N. Kirby Alton                    Director                                  March 13, 1995
                                                                     
/s/ DR. MICHAEL BEVILACQUA                                                                     
- ----------------------------                                             
Dr. Michael Bevilacqua                Director                                  March 14, 1995
                                                                     
/s/ Dr. GEORGE MORSTYN                                                                     
- ---------------------------                                              
Dr. George Morstyn                    Director                                  March 13, 1995
                                                                     
/s/ DR. DANIEL VAPNEK                                                                     
- ---------------------------                                              
Dr. Daniel Vapnek                     Director                                  March 13, 1995
</TABLE>                                                             





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