XYTRONYX INC
424B3, 1997-09-09
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

                                        This filing is made pursuant to Rule
                                        424(b)(3) under the Securities Act of
                                        1933 in connection with Registration
                                        Statement No. 333-26109


PROSPECTUS SUPPLEMENT NO. 1
(TO PROSPECTUS DATED SEPTEMBER 4, 1997)


                      19,831,145 SHARES OF COMMON STOCK

                         6,500,188 CLASS A WARRANTS

                        PACIFIC PHARMACEUTICALS, INC.


     This Prospectus Supplement supplements information contained in that 
certain prospectus dated September 4, 1997 (the "Prospectus") relating to 
19,831,145 shares of Common Stock and 6,500,188 Class A Warrants of Pacific 
Pharmaceuticals, Inc. (the "Company") being offered for the account of 
certain persons named therein under "Selling Shareholders" or by pledgees, 
donees, transferees or other successors in interest of the Selling 
Shareholders. This Prospectus Supplement is not complete without, and may not 
be delivered or utilized except in connection with, the Prospectus, including 
amendments or supplements thereto. Capitalized terms used but not defined 
herein have the meanings assigned to them in the Prospectus; except where the 
context otherwise requires, the term "Prospectus" includes this Prospectus 
Supplement.

     The table of Selling Shareholders which starts on page 20 of the 
Prospectus is amended, with respect to the named Selling Stockholder's set 
forth below and the information set forth below, as follows:

                                         SECURITIES OFFERED BY THIS PROSPECTUS
                                         -------------------------------------
NAME OF SELLING STOCKHOLDER              COMMON STOCK                 WARRANTS
- ---------------------------              ------------                 --------
Mark Abeshouse(8)                               7,323                    2,375
Joseph Edelman(8)                              14,401                    4,671
Joseph A. Fabiani, Jr.(8)                       4,240                    1,375
Marc Florin(8)                                 32,992                   10,700
Peter M. Kash(8)                               29,099                    9,438
Scott A. Katzmann(8)                          158,483                   51,400
Martin S. Kratchman(8)                          3,854                    1,250
Stephen McDermott(8)                            1,927                      625
Tim McInerney(8)                               51,839                   16,813
Paramount Capital Inc.(3)(5)                  554,928                  179,977
Lindsay A. Rosenwald(5)                     2,374,016                  769,951




<PAGE>

                                         SECURITIES OFFERED BY THIS PROSPECTUS
                                         -------------------------------------
NAME OF SELLING STOCKHOLDER              COMMON STOCK                 WARRANTS
- ---------------------------              ------------                 --------
Wayne L. Rubin(8)                              74,749                   23,243
Karl Ruggeberg(8)                               9,558                    3,100
Deborah Soloman(8)                              3,854                    1,250
David Walner(7)                                24,175                    7,841
Michael S. Weiss(6)                            74,749                   24,243


         THE DATE OF THIS PROSPECTUS SUPPLEMENT IS SEPTEMBER 9, 1997




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