PACIFIC PHARMACEUTICALS INC
DEF 14A, 1998-07-08
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>

                                    SCHEDULE 14A
                                   (Rule 14a-101)
                                          
                      INFORMATION REQUIRED IN PROXY STATEMENT
                              SCHEDULE 14A INFORMATION
                                          
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                          
                                          
Filed by the Registrant  [X]
Filed by a Party other than the Registrant  [ ]
                                          
Check the appropriate box:
[ ]  Preliminary Proxy Statement     [ ] Confidential, for Use of the Commission
                                         Only (as permitted by Rule 14a-6(e)(2))

[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                          PACIFIC PHARMACEUTICALS, INC. 
                  ------------------------------------------------
                  (Name of Registrant as Specified in its Charter)


     ------------------------------------------------------------------------
     (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of Filing Fee (Check the appropriate box):

[X]  No fee required
[  ] $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), or 14a-6(j)(2) 
     or Item 22(a)(2) of Schedule A 
[  ] $500 per each party to the controvery pursuant to Exchange Act 
     Rule 14a-6(i)(3).
[  ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     (1)  Title of each class of securities to which transaction applies:

- -------------------------------------------------------------------------------
     (2)  Aggregate number of securities to which transaction applies:

- -------------------------------------------------------------------------------
     (3)  Per unit price of other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11
          (Set forth the amount on which the filing fee is calculated and 
          state how it was determined):

- -------------------------------------------------------------------------------
     (4)  Proposed maximum aggregate value of transaction:

- -------------------------------------------------------------------------------
     (5)  Total fee paid:

- -------------------------------------------------------------------------------
     [  ] Fee paid previously with preliminary materials

- -------------------------------------------------------------------------------
     [  ] Check box if any part of the fee is offset as provided by Exchange
          Act Rule 0-11(a)(2) and identify the filing for which the offsetting 
          fee was paid previously.  Identify the previous filing by 
          registration statement number, or the Form or Schedule and the date 
          of its filing.

     (1)  Amount Previously Paid: 
                                  ----------------------------------------------
     (2)  Form, Schedule or Registration Statement No.:
                                                        ------------------------
     (3)  Filing Party:
                       ---------------------------------------------------------
     (4)  Date Filed:
                     -----------------------------------------------------------
                                          
<PAGE>

                            PACIFIC PHARMACEUTICALS, INC.
                            6730 MESA RIDGE ROAD, SUITE A
                                 SAN DIEGO, CA 92121
                                    (619) 550-3900

                                     ------------

                       NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                              TO BE HELD AUGUST 13, 1998

                                     ------------

Notice is hereby given that an Annual Meeting (the "Meeting") of the 
Stockholders of Pacific Pharmaceuticals, Inc., a Delaware corporation (the 
"Company"), will be held at the offices of Patterson, Belknap, Webb & Tyler 
LLP, 1133 Avenue of the Americas, New York, NY 10036, on Thursday, August 13, 
1998, at 10:00 a.m. E.S.T., and at any adjournments thereof, for the 
following purposes:

     1.  To elect six Directors to hold office for a one-year term or until
     their successors are elected and qualified.  The following persons are
     nominees (the "Nominees") for election to the Board of Directors by
     holders of the outstanding shares entitled to vote:  Drs. and Messrs.
     H. Laurence Shaw, Robert A. Vukovich, Jack H. Halperin, John G.
     Kringel, Elliott H. Vernon and Michael S. Weiss;

     2.  To authorize the Company to enter into and perform agreements, in
     connection with a private placement financing by the Company and the
     Company's subsidiary, BG Development Corp. ("BGDC"), to exchange
     shares of BGDC Convertible Preferred Stock for shares of the Company's
     Common Stock under certain circumstances (the "Exchange Right");

     3.  To consider and act upon a proposal to ratify the selection of
     Deloitte & Touche LLP as the Company's independent public accountants
     for the fiscal year ending March 31, 1999; and

     4.  To consider and act on such other business as may properly be
     presented at the Meeting.

<PAGE>

A record of the stockholders has been taken as of the close of business on 
June 26, 1998 (the "Record Date"), and only those stockholders of record on 
the Record Date will be entitled to notice of and to vote at the Meeting.  A 
complete list of the stockholders entitled to vote at the Meeting arranged in 
alphabetical order, and showing the address of such stockholder and the 
number of shares registered in the name of each stockholder, will be kept 
open at the offices of Patterson, Belknap, Webb & Tyler LLP, 1133 Avenue of 
the Americas, New York, NY 10036, for examination by any stockholder during 
business hours for a period of ten (10) days immediately prior to the Meeting.

The votes of a majority of the shares present at the meeting in person or by 
proxy is required for the approval of the Nominees, for the approval of the 
Exchange Right and to ratify the selection of Deloitte & Touche LLP as the 
Company's independent accountants.

Your participation in the Meeting is important.  To ensure your 
representation, if you do not expect to be present at the Meeting, please 
sign and date the enclosed proxy and return it promptly in the enclosed 
postage-prepaid envelope which has been provided for your convenience.  A 
proxy may be revoked by a later dated, properly executed proxy.  The prompt 
return of proxies will ensure a quorum for the Meeting and save the expense 
of a further solicitation.

                              BY ORDER OF THE BOARD OF DIRECTORS



                              /S/ DR. H. LAURENCE SHAW
                              ------------------------
                              DR. H. LAURENCE SHAW
                              PRESIDENT AND CHIEF EXECUTIVE OFFICER


SAN DIEGO, CALIFORNIA
JULY 8, 1998

          IT IS IMPORTANT THAT YOUR SHARES BE PRESENTED AT THE MEETING.  YOUR 
VOTE IS IMPORTANT REGARDLESS OF THE NUMBER OF SHARES YOU OWN, PLEASE EXECUTE 
THE ENCLOSED PROXY AND RETURN IT PROMPTLY IN THE ENVELOPE PROVIDED.

<PAGE>



                          PACIFIC PHARMACEUTICALS, INC.
                          6730 MESA RIDGE ROAD, SUITE A
                               SAN DIEGO, CA 92121
                                 (619) 550-3900
                                  JULY 8, 1998

                                 --------------

                                 PROXY STATEMENT

                                 --------------

                             SOLICITATION OF PROXIES


This proxy statement (the "Proxy Statement") is furnished in connection with the
solicitation of proxies by the Board of Directors of Pacific Pharmaceuticals,
Inc., a Delaware corporation (the "Company"), for use at the Annual Meeting (the
"Meeting") of Stockholders, to be held at the offices of Patterson, Belknap,
Webb & Tyler LLP, 1133 Avenue of the Americas, New York, NY 10036, on Thursday,
August 13, 1998, at 10:00 a.m. E.S.T. and at any adjournments thereof.

Shares of capital stock of the Company entitled to vote at the Meeting which are
represented by properly executed and dated proxies returned prior to the Meeting
will be voted at the Meeting in accordance with the specifications thereon.
Shares represented by valid proxies will be voted in accordance with the
instructions indicated thereon and otherwise in accordance with the judgment of
the persons designated as the holders of the proxies. Any proxy on which no
direction is specified will be cast: FOR Proposal 1 to elect the Nominees as
Directors; FOR Proposal 2 to authorize the Company to enter into and perform
agreements, in connection with a private placement financing by the Company and
the Company's subsidiary, BG Development Corp. ("BGDC"), to exchange shares of
BGDC Convertible Preferred Stock for shares of the Company's Common Stock under
certain circumstances (the "Exchange Right"); and FOR Proposal 3 to ratify the
selection of Deloitte & Touche LLP as the Company's independent public
accountants for the fiscal year ending March 31, 1999. The proxy also confers
discretionary authority on the persons designated therein to vote on other
business, not currently contemplated, which may come before the Meeting.

Any stockholder giving a proxy has the right to revoke it by giving written
notice to the Secretary of the Company or by duly executing and delivering a
proxy bearing a later date or by attending the Meeting and giving oral notice to
the Secretary at any time prior to the voting.

This Proxy Statement, accompanying form of proxy and the Fiscal 1998 Annual
Report to Stockholders, including financial statements, are first being mailed
to stockholders on or about July 13, 1998.


                                        1
<PAGE>

A complete list of the stockholders entitled to vote at the Meeting arranged 
in alphabetical order, showing their address and the number of shares 
registered in the name of each stockholder, will be kept open at the offices 
of Patterson, Belknap, Webb & Tyler LLP, 1133 Avenue of the Americas, New 
York, NY 10036, for examination by any stockholder during business hours for 
a period of ten (10) days immediately prior to the Meeting.

The cost of the solicitation of proxies for the Meeting will be paid by the 
Company. In addition to solicitation of proxies by use of mails, Directors, 
Officers and employees of the Company may solicit proxies personally, or by 
other appropriate means. The Company will request banks, brokerage houses and 
other custodians, nominees or fiduciaries holding stock in their names for 
others to send proxy materials to, and to obtain proxies from the beneficial 
holders of such stock, and the Company will reimburse them for their 
reasonable expenses in doing so.

QUORUM

The presence in person or by proxy of stockholders of a majority of the 
outstanding shares entitled to vote is required for there to exist the quorum 
needed to transact business of the Meeting. If, initially, a quorum should 
not be present, the Meeting may be adjourned from time to time until a quorum 
is obtained.

VOTE REQUIRED FOR APPROVAL

The affirmative vote of the holders of a majority of the voting power of the 
common stock, par value $.02 per share (the "Common Stock") and the Series A 
Convertible Preferred Stock, par value $25.00 per share (the "Preferred 
Stock"), present at the meeting in person or by proxy is required for the 
approval of the Nominees as Directors, for the approval of the Exchange Right 
and to ratify the selection of Deloitte & Touche LLP as the Company's 
independent accountants.

Abstentions and "broker non-votes" (as defined below) are counted for 
purposes of determining whether a quorum is present, but do not represent 
votes cast with respect to any proposal. Abstention from voting on any matter 
will have the practical effect of voting against any of the proposals since 
it is one less vote for approval. Broker non-votes are not considered to be 
shares "entitled to vote" (other than for quorum purposes), and will 
therefore have the effect of reducing the absolute number of votes required 
for stockholders to approve Proposals 1, 2, and 3. "Broker non-votes" are 
shares held by a broker or nominee for which an executed proxy is received by 
the Company, but are not voted as to one or more proposals because 
instructions have not been received from the beneficial owners or persons 
entitled to vote and the broker or nominee does not have discretionary power 
to vote.

APPRAISAL RIGHTS

Stockholders will not have appraisal rights with respect to any of the proposals
to be voted upon at the Meeting. Delaware law does not require that holders of
the Common Stock and Preferred Stock


                                        2
<PAGE>

who object to any or all of the Proposals, and who vote against or abstain 
from voting in favor of any or all of the Proposals, be afforded any 
appraisal or dissenters' rights or the right to receive cash for their shares.

RECORD DATE AND OUTSTANDING VOTING SECURITIES

The securities of the Company entitled to vote at the Meeting consist as of 
June 26, 1998, the record date fixed by the Board of Directors (the "Record 
Date"), of 11,257,021 shares of Common Stock, and 38,446 shares of Preferred 
Stock. Each share of Common Stock is entitled to one vote on all matters 
presented to the stockholders. Each share of Preferred Stock outstanding as 
of the record date is entitled to 290.89 votes on all matters presented to 
the stockholders. Only stockholders of record on the books of the Company at 
the close of business on the Record Date will be entitled to vote at the 
Meeting.

RECOMMENDATION OF THE BOARD OF DIRECTORS

The Board of Directors unanimously recommends that the Company's stockholders 
vote (i) FOR the election of the Nominees as Directors, (ii) FOR approval of 
the Exchange Right, and (iii) FOR ratification of the selection of Deloitte & 
Touche LLP as the Company's independent public accountants for the fiscal 
year ending March 31, 1999.

AVAILABLE INFORMATION

The Company's Annual Report to Stockholders for the Fiscal Year ending March 
31, 1998, including financial statements, accompanies this Proxy Statement. 
Stockholders and Preferred Stockholders may obtain (free of charge) a copy of 
the Company's most recent Annual Report on Form 10-K, excluding Exhibits, as 
filed with the Securities and Exchange Commission (the "SEC") by writing to 
Pacific Pharmaceuticals, Inc., Attention: Investor Relations, at the address 
shown on Page 1.

The Company is subject to the informational requirements of the Securities 
Exchange Act of 1934, as amended, and the rules and regulations promulgated 
thereunder (the "Exchange Act"), and in accordance therewith files reports, 
proxy statements and other information with the SEC. The reports, proxy 
statements and other information filed by the Company with the SEC can be 
inspected and copied at the public reference facilities maintained by the SEC 
at Room 1024, 450 Fifth Street, N.W., Washington, D.C. 20549, and at the 
SEC's Regional Offices at Seven World Trade Center, 13th Floor, New York, NY 
10007 and at Citicorp Center, 500 West Madison Street, Suite 1400, Chicago, 
Illinois 60661-2511. Copies of such material also can be obtained from the 
Public Reference Section of the SEC at Judiciary Plaza, 450 Fifth Street, 
N.W., Washington, D.C. 20549 at prescribed rates. Information filed with the 
SEC can also be inspected at the SEC's site on the World Wide Web at 
http://www.sec.gov. In addition, material filed by the Company can be 
inspected at the offices of the American Stock Exchange ("Amex") at 86 
Trinity Place, New York, NY 10006.


                                        3
<PAGE>

                             EXECUTIVE COMPENSATION

The information under this heading relates to the compensation of the Chairman
of the Board (who was also the Chief Executive Officer at Fiscal 1998 year-end)
and the other most highly compensated executive officer of the Company as of the
Fiscal 1998 year-end for services in all capacities during Fiscal 1998. This
information is presented in compliance with the rules and regulations of the
Securities and Exchange Commission applicable to those companies, such as
Pacific Pharmaceuticals, Inc., that meet the definition of a "small business
issuer".


                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                                              Long-Term Compensation
                              ----------------------------------------------------------------------------------------------
                                                       Annual Compensation                     Awards            Payouts 
- ----------------------------------------------------------------------------------------------------------------------------
          Name and                                                                    Restricted     Number        LTIP
          Principal             Fiscal                                                   Stock         of         Payout
          Position               Year      Salary          Bonus         Other           Awards      Options      Amount
                                                                                         Amount
- ---------------------------------------------------------------------------------------------------------------------------
<S>                              <C>      <C>              <C>         <C>               <C>          <C>           <C>
H. Laurence Shaw, M.D.           1998     $ 253,646        $ 35,000    $ 150,439 (a)     $ 56,875     200,000       $ -
   Chairman of the               1997     $  64,000 (b)    $ 25,000    $  23,493         $   -        675,000       $ -
   Board and Chief                                                                          
   Executive Officer

Anil K. Singhal, Ph.D. (c)       1998     $ 125,437         $ 20,000   $      -           $ 8,750     225,000       $ -
   Vice President - R & D

</TABLE>

(a)  Includes $13,401 for reimbursement of health, life and disability insurance
     coverage and $137,038 for reimbursement of relocation costs.

(b)  Represents approximately three months' compensation earned after Dr. Shaw
     joined the Company in December 1996.

(c)  Dr. Singhal joined the Company in April 1997.



                                        4

<PAGE>



                            COMPENSATION PURSUANT TO PLANS

        INDIVIDUAL OPTION GRANTS TO EXECUTIVE OFFICERS DURING FISCAL 1998

<TABLE>
<CAPTION>
                                                                                    Potential Realizable Value
                                          Percent                                        at Assumed Annual
                       Number of          of Total                                     Rates of Stock Price
                        Securities        Options                                        Appreciation for
                      Underlying         Granted to                                         Option Term
      Name of           Options          Employees    Exercise   Expiration    -------------------------------------
 Executive Officer       Granted         in FY 1997     Price       Date               5%                10%
- --------------------------------------------------------------------------------------------------------------------
<S>                    <C>                  <C>        <C>        <C>               <C>               <C>
H. Laurence Shaw       200,000 (a)          22%        $ 0.90625  02/10/08          $ 185,251         $ 402,342
                                        
Anil Singhal           150,000 (b)          16%        $ 1.0625   04/16/07          $ 100,230         $ 254,003
                        75,000 (c)           8%        $ 0.75     03/12/08          $  73,553         $ 150,439
</TABLE>

(a)  66,667 options vest on January 1, 1999, 66,667 vest on January 1, 2000 and 
     66,666 vest on January 1, 2001.

(b)  100,000 options become exercisable in four equal annual installments after
     the first anniversary of the grant date. 50,000 options vest upon
     achievement of certain milestones. As of March 31, 1998, 40,000 options
     were vested.

(c)  Options become exercisable in four equal annual installments after the
     first anniversary of the grant date.


  AGGREGATED OPTION EXERCISES IN FISCAL 1998 AND FISCAL YEAR END 1998 OPTION 
                                   VALUES

<TABLE>
<CAPTION>
                                                              Number of
                                                        Securities Underlying             Value of Unexercised
                          Number of                      Unexercised Options              In-The-Money Options
                           Shares                         at March 31, 1998                 at March 31, 1998
Name of                   Acquired      Value      -------------------------------- ---------------------------------
Executive Officer        on Exercise   Realized      Exercisable    Unexercisable     Exercisable    Unexercisable
- -------------------------------------------------  -------------------------------- ---------------------------------
<S>                         <C>          <C>           <C>              <C>              <C>              <C>
H. Laurence Shaw             -           $ -           365,625          509,375          $ -              $ -

Anil K. Singhal              -           $ -            40,000          185,000          $ -              $ -

</TABLE>

EMPLOYMENT AGREEMENT

Dr. Shaw has an employment agreement (the "Employment Agreement") with the
Company for an initial two year period beginning December 17, 1996, subject to
renewal upon mutual agreement. The Employment Agreement provides that the
Company will pay Dr. Shaw an initial salary of $250,000 per annum, subject to
certain annual increases. Effective January 1, 1998, the Company increased Dr.
Shaw's annual salary to $262,500. Under the Employment Agreement, Dr. Shaw is
also entitled to receive a minimum annual bonus of $25,000, with an additional
annual milestone-based bonus at the discretion of the Board of Directors of up
to an additional $125,000. The 


                                        5
<PAGE>

Employment Agreement also provides for the Company to pay Dr. Shaw 
compensation equal to his salary and minimum bonus for a period of 12 months 
in the event of his early termination from the Company for a reason other 
than just cause or in the event that Dr. Shaw terminates the Employment 
Agreement for (i) a material breach of the Employment Agreement by the 
Company, (ii) the failure of the Company to elect Dr. Shaw to the office of 
Chief Executive Officer, President and Director of the Company, (iii) a 
reduction in Dr. Shaw's base salary or other benefits of a material economic 
effect, or (iv) in the event of a "change of control" of the Company. A 
"change of control" is defined in the Employment Agreement to mean a merger 
or consolidation in which either more than fifty percentage of the voting 
power of the Company is transferred or the Company is not the surviving 
entity, or the sale or other disposition of all or substantially all the 
assets of the Company.

COMPENSATION OF DIRECTORS

Directors who are not employees of the Company currently receive an annual 
retainer of $3,000 and a fee of $1,000 for each Board meeting attended in 
person. The Company also reimburses Directors for reasonable travel and 
related expenses incurred in attending meetings. Officers of the Company who 
serve on the Board or any Committee thereof receive no compensation for doing 
so.

The Company grants 50,000 options to each new Director pursuant to the 
Company's Stock Option Plan for Non-Employee Directors (the "Director Plan"). 
In addition, the Director Plan calls for annual grants of 10,000 options for 
each Director at the market price on the date of the Annual Stockholders' 
Meeting.



                                        6
<PAGE>

                  BENEFICIAL AND RECORD OWNERSHIP OF SECURITIES

The following table sets forth certain information as of June 26, 1998, with
respect to the beneficial ownership of the Company's Common Stock and Preferred
Stock by (a) each person who is known to the Company to own beneficially more
than 5% of the outstanding shares of Common Stock and Preferred Stock; (b) each
present executive officer, Director and Nominee, and (c) all Executive Officers,
Directors and Nominees as a group. Except as otherwise indicated, the address of
each person is care of Pacific Pharmaceuticals, Inc., 6730 Mesa Ridge Road,
Suite A, San Diego, CA 92121.

<TABLE>
<CAPTION>
                                          Common Stock           Preferred Stock       
                                          ------------           ---------------           % of Total
              Name                     Shares (1)(2)     %      Shares(1)(2)     %          Voting Power
              ----                     -------------     -      ------------     -          ------------
<S>                                      <C>           <C>        <C>          <C>            <C>
Paramount Capital Asset
Management, Inc. (3)                     2,426,400     17.29%     14,338       27.10%         26.43%

Dr. Lindsay Rosenwald (3)                2,858,783     19.76%     24,684       39.03%         34.19%

The Aries Trust (3)                      1,445,250     11.07%      9,461       19.70%         17.52%

Aries Domestic Fund, L. P. (3)             981,150      7.79%      4,877       11.23%         10.28%

Lou Weisbach
5980 West Touhy Ave.
Niles, IL 60714                            955,100      7.84%          -            -          4.26%

Dr. H. Laurence Shaw                       460,000      3.96%          -           -           2.01%

Anil K. Singhal                             67,000          *                                    *

Jack H. Halperin                            54,800          *          -           -             *

John G. Kringel                             37,500          *          -           -             *

Elliott H. Vernon                           47,900          *          -           -             *

Michael S. Weiss (4)                       113,174      1.00%      1,557       3.88%         2.46%

Robert A. Vukovich                          29,300          *          -           -             *

All Directors and Executive
Officers as a group (7 persons)            809,674      7.22%      1,557       3.88%         5.52%

</TABLE>


                                        7
<PAGE>


(1) The inclusion of any shares deemed beneficially owned does not constitute 
an admission by the person named that he is the beneficial owner of those 
shares. Beneficial ownership also includes shares of Common Stock which may 
be acquired within 60 days of June 26, 1998 through the exercise of warrants 
or options as follows: Dr. Rosenwald, 2,458,783 shares; Aries Domestic Fund, 
L.P., 781,150 shares; The Aries Trust, 1,245,250 shares; Paramount Capital 
Asset Management, Inc., 2,026,400 shares; Dr. Shaw, 450,000; Dr. Singhal, 
65,000; Mr. Halperin, 54,800 shares; Mr. Kringel, 32,500 shares; Mr. Vernon, 
47,900 shares; Mr. Weiss, 113,174 shares; and all Directors and Executive 
Officers as a group 785,874 shares. Beneficial ownership also includes shares 
of Preferred Stock which may be acquired within 60 days of June 26, 1998 
through the exercise of warrants as follows: Dr. Rosenwald, 12,045 shares; 
Aries Domestic Fund, L.P., 578 shares; Aries Trust, 1,121 shares; Paramount 
Capital Asset Management, Inc., 1,699 shares; and Mr. Weiss, 1,558 shares. 
Although the Preferred Stock is convertible into Common Stock, it is not 
reflected on an as-converted basis in the Common Stock Column because, as a 
voting security, it is reflected in its own column.

(2) To the best of the Company's knowledge, unless otherwise indicated, the 
beneficial owners names in column one have sole voting and investment power 
with respect to the shares held.

(3) Reflects beneficial ownership in accordance with Rule 13d-3 under the 
Securities Exchange Act of 1934. Paramount Capital Asset Management, Inc. is 
the general partner of Aries Domestic Fund, L.P., and is the investment 
manager of the Aries Trust, and therefore may be deemed to be the beneficial 
owner of shares beneficially owned by each. Dr. Lindsey Rosenwald is the 
President and sole shareholder of Paramount Capital Asset Management, Inc. 
and may therefore deemed to be the beneficial owner of shares beneficially 
owned by Paramount, and each of the Fund and the Trust, although he disclaims 
such beneficial ownership except to the extent of his primary interests. 
Other than the 2,426,400 shares of Common Stock and the 14,338 shares of 
Preferred Stock attributed to Dr. Rosenwald through the holdings of Paramount 
Capital Asset Management, Inc., Dr. Rosenwald's attributed beneficial 
ownership consists of 432,383 shares of Common Stock and 10,346 of Preferred 
Stock underlying certain warrant exercisable within 60 days.

(4) Includes warrants to purchase 46,174 shares of Common Stock and 1,557 
shares of Preferred Stock. Mr. Weiss disclaims beneficial ownership of all 
shares owned by other employees of principals of Paramount or Paramount 
Capital.

*  Less than 1%


                                       8
<PAGE>

                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

Six Directors are to be elected at the Meeting, each to serve for a term of 
one year and until his successor shall be duly elected and qualified. The 
proxies solicited hereby are intended to be voted FOR the Nominees whose 
names are listed below unless authority to vote for election of any or all of 
such nominees is withheld by marking the proxy to that effect. If a quorum is 
present, the six nominees receiving an affirmative vote of the holders of a 
majority of the Common Stock and Preferred Stock represented and entitled to 
vote at the Meeting in person or by proxy shall be elected. Shares with 
respect to which authority to vote for a nominee or nominees is withheld will 
not be counted in the total number of shares voted for such nominee or 
nominees. The Company has no reason to believe that any nominee will not be 
available for election to serve his prescribed term. However, if any nominee 
should for any reason be unable to serve, the shares represented by all valid 
proxies will be voted for the election of such other person as the Board may 
recommend in his place, or the Board may reduce the number of Directors to 
eliminate the vacancy.

Pursuant to the Company's Bylaws, the size of Board of Directors is currently 
fixed at nine members. However, the Board has nominated only the six existing 
Board members for election at this time. Votes cannot be cast, either in 
person or by proxy, for a greater number of persons than the number of 
nominees named herein.

The following table sets forth the name and age of each nominee and the 
positions and offices with the Company held by him, his principal occupation 
and business experience during the past five years, and the year of 
commencement of his term as a Director of the Company.

               THE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS THAT 
STOCKHOLDERS VOTE FOR THE ELECTION OF THE FOLLOWING NOMINEES:

H. LAURENCE SHAW, M.D., Chairman, President and Chief Executive Officer, 52, 
became a Director in 1996. From 1995 to 1996, Dr. Shaw served as Corporate 
Vice President Research & Development of C.R. Bard. Prior to that, from 
1993-1995, Dr. Shaw served as Chief Executive Officer, President and Director 
of Atlantic Pharmaceuticals, Inc. and Chief Executive Officer of each of 
Atlantic's operating companies from their inception in 1993. From 1984-1993, 
he was Vice President, Medical and Regulatory Affairs and Advanced Research 
at Abbott Laboratories. From 1981-1984, he was a board member of Revlon 
Health Care, Ltd. (UK) and Director, Medical and Technical Affairs. At 
Revlon, he was responsible for pharmaceutical formulation and development, 
new business development and clinical research for Revlon's major research 
unit outside of the USA. Prior to Revlon, he served as International Medical 
Director for Meadox Medical Inc.; Medical Director for Merck in the UK; and 
as Associate Director for SmithKline Corporation. Dr. Shaw is a graduate of 
the University College Hospital Medical School, London, UK and has worked in 
clinical practice in the UK and in the USA. He is a 


                                        9
<PAGE>

Fellow of the Faculty of Pharmaceutical Medicine of the Royal College of 
Physicians, a Fellow of the American College of Clinical Pharmacology and a 
member of many professional associations. Dr. Shaw also serves on the Board 
of directors of Endorex Corporation and is the Chairman, President and CEO of 
BG Development Corp.

JACK H. HALPERIN, 51, became a Director in 1992. Mr. Halperin is a corporate 
and securities attorney with expertise in financing transactions who has 
practiced independently since 1987. Mr. Halperin was a member of the law firm 
of Solinger Grosz & Goldwasser, P.C. from 1981 to 1987. Mr. Halperin has a 
B.A. from Columbia College and a J.D. from New York University School of Law. 
Mr. Halperin is a member of the Board of Directors of I-Flow Corporation, 
AccuMed International, Inc., Memory Corporation and Nocopi Technologies, Inc.

JOHN G. KRINGEL, 59, became a Director in 1997. Mr. Kringel, was Senior Vice 
President of Hospital Products and President of Hospital Products Division of 
Abbott Laboratories from October 1990 and September 1983 until June 30, 1998. 
He joined Abbott in 1980 as divisional vice president of corporate planning 
and development. From 1977 to 1980, Kringel was associated with the 
Warner-Lambert Co., where he was executive vice president of American Optical 
Corporation and president of the vision care and safety products division. 
Prior to that, Kringel was general manager of the U.S. medical division of 
Corning Glass Works. Mr. Kringel is a member of the Board of Directors of 
Lakeland Health Services, Inc., and the Board of Trustees of Highland Park 
Hospital and Chairman of Groveland Health Services Board of Trustees. He is 
also Chairman of Lakeland Health Ventures, Inc.'s Board of Directors. He is a 
member of the Board and Chairman of the Northeast Illinois Council of the Boy 
Scouts of America, Member of the Board of Directors of the American Society 
of Hospital Pharmacists Research & Education Foundation, and a member of the 
Board of Directors of Navix Radiology Systems, Inc.

ELLIOTT H. VERNON, 55, became a director in 1995. Mr. Vernon has been the 
Chairman of the Board and Chief Executive Officer of Healthcare Imaging 
Services, Inc., a publicly held health care management and services company 
that supplies state-of-the-art medical equipment and services to physicians, 
hospitals, and other health care providers in the Northeast region since its 
inception in 1991. Mr. Vernon is also the managing partner of MR General 
Associates, a New Jersey general partnership and the general partner of DMR 
Associates, and has held such positions for the past seven years. Mr. Vernon 
is Of Counsel to the law firm of Schottland, Aaron, Plaza, Costanzo & 
Manning, Esq., with offices in New York and New Jersey. Mr. Vernon is 
currently a director of Transworld Home Healthcare, Inc., a publicly held 
regional supplier of a broad range of alternate site healthcare services and 
products.

ROBERT A. VUKOVICH, Ph.D., 55, became a Director in January 1998. Dr. 
Vukovich founded Roberts Pharmaceutical in 1983 and served as Chairman of the 
Board, Chief Executive Officer and President until September 1997, and is 
presently Executive Chairman. From 1979-1983, he was the worldwide divisional 
director of Developmental Therapeutics at Revlon Health Care Group, and held 
positions prior to 1979 in drug development with the Squibb Institute for 


                                        10
<PAGE>

Medical Research and Warner Lambert Research Institute. Dr. Vukovich is also 
a member of the Board of Directors for Cypros Pharmaceutical, Entrepreneur of 
the Year Institute, Biotransplant, Inc., and is on the Board of Trustees at 
Allegheny College. He is a graduate of Jefferson Medical College.

MICHAEL S. WEISS, 32, became a director in 1995. Mr. Weiss is Senior Managing 
Director of Paramount Capital, Inc., an investment banking firm and certain 
affiliated entities. He joined the companies is 1993. Prior to that, Mr. 
Weiss was an attorney with Cravath, Swaine & Moore. Mr. Weiss is Vice 
Chairman of Genta, Incorporated and Chairman of Procept, Inc. Mr. Weiss also 
serves as a director of AVAX Technologies, and Palatin Technologies, Inc. and 
is secretary of Atlantic Pharmaceuticals, Inc., all of which are publicly 
traded biotechnology companies. Mr. Weiss is also currently a member of the 
Board of Directors of several privately held biopharmaceutical companies, 
including Nephros, Inc. and Cardio Technologies, Inc. Mr. Weiss is also a 
Director and Secretary and of Binary Therapeutics, Inc and is a Director and 
Secretary of BG Development Corp. Mr. Weiss received his J.D. from Columbia 
University School of Law and a B.S. in Finance from The State University of 
New York at Albany.

COMMITTEES OF THE BOARD OF DIRECTORS

The Board of Directors met five times during fiscal year 1998. The Company's 
Board of Directors has an Audit Committee and Executive Compensation and 
Stock Option Committee. The Board has no nominating or similar committee. The 
current members of the Audit Committee are Messrs. Kringel, Halperin and 
Weiss. This committee monitors the Company's basic accounting policies, 
reviews audit and management reports and makes recommendations regarding the 
appointment of the independent auditors. The Audit Committee met once during 
the last fiscal year, and otherwise its responsibilities were assumed by the 
full Board of Directors. The members of the Executive Compensation Committee 
and Stock Option Committee are Messrs. Halperin, Vernon and Vukovich. This 
committee, which met once during the last fiscal year and reviews and 
determines appropriate Officer compensation and administers and makes awards 
under the various stock option plans. During fiscal 1998, all of the 
Company's Directors attended at least 75% of the meetings of the full Board 
and of committees of which they were members.

The affirmative vote of the holders of a majority of the voting power of the 
Common Stock and Preferred Stock present at the Meeting in person or by proxy 
is required to approve the election of the Nominees as Directors of the 
Company.


                                        11
<PAGE>

                                   PROPOSAL 2

                           APPROVAL OF EXCHANGE RIGHT

RIGHTS TO O6 BENZYL GUANINE COMPOUND

In March 1998, the Company and Pennsylvania State University (the 
"Licensor"), entered into an exclusive, worldwide, royalty bearing license 
agreement (the "License") with the right to grant sublicenses to certain 
patents and patent applications relating to the manufacture and use of 
proposed products incorporating O6 Benzyl Guanine ("BG"). The Company, in 
turn, assigned the License to its subsidiary, B-G Development Corp. ("BGDC"), 
pursuant to an Assignment and Assumption Agreement dated April 20, 1998 (the 
"Assignment"), and BGDC issued 7,500,000 shares of its common stock, par 
value $.001 per share, to the Company. In accordance with the Assignment, 
BGDC has assumed the obligations of the Company under the License, including 
royalty and other payments more fully described below, provided that Pacific 
guarantees such payments. Additionally, BGDC and the Company have entered 
into a one-year renewable Corporate Services and Management Agreement 
pursuant to which the Company will provide financial/accounting, 
administrative, advisory and managerial support to BGDC. For such services, 
the Company will receive from BGDC a management fee equal to $500,000 per 
year, payable in equal monthly installments. Because of the sale of the BGDC 
Preferred Stock (as defined below), BGDC is no longer a wholly owned 
subsidiary of the Company but is, and will be at all times following any 
closing in the Transaction (as defined below) be majority owned by the 
Company. See "Transaction Giving Rise To The Exchange Right" below.

The Company has had preliminary discussions with the N.I.H. with respect to 
entering into a Cooperative Research and Development Agreement ("CRADA") for 
BG. Pursuant to the CRADA, the N.I.H. would, among other things, make 
available to BGDC (a) all N.I.H. clinical data relating to any potential 
products incorporating BG developed or generated by the N.I.H. prior to the 
date of the CRADA and (b) all subsequent data developed under such CRADA. The 
Company estimates that, pursuant to the CRADA, it would be required to pay 
approximately $125,000 per year to the N.I.H.

In accordance with the terms of the License, the Company has agreed to pay to 
the Licensor a percentage of sales of Licensed Products as well as certain 
performance-based milestones. The Company has also agreed to pay the Licensor 
a non-refundable minimum annual royalty (the "Minimum Annual Royalty") equal 
to $75,000 per year creditable against future milestone payments and third 
party payments, commencing upon execution of the License but subject to 
certain deferrals. Additionally, the Company will pay to the Licensor 
$150,000 as an up-front licensing fee, payable upon the earlier to occur of 
(a) receipt by the Company of the National Cancer Institute (the "N.C.I.") 
Clinical Data and pre-clinical data or (b) the date that is six months from 
the Effective Date, payable in cash or equity at the discretion of the 
Company. The Company may fulfill up to 75% of its payment obligations 
resulting from Minimum Annual Royalties or performance milestones through 


                                        12
<PAGE>

the issuance of a number of shares of the Company's Common Stock equal to the 
cash value of such payments for this purpose, the Company's common stock 
shall be valued at the average closing price of the Company's Common Stock on 
the 10 consecutive trading days prior to (a) the date of achievement of any 
such milestone or (b) the date on which such payment accrues. To the extent 
that the Company satisfies any of the payment obligations under the License 
through the issuance of the Company's Common Stock, BGDC has agreed to 
reimburse the Company with a cash payment of the obligation amount.

Upon receipt of appropriate documentation of past patent expenses, the 
Company shall also pay to the Licensor the approximate amount of $200,000 
(for which BGDC has agreed to reimburse the Company) in installments 
commencing upon the earlier to occur of (a) receipt by the Company of the 
N.C.I. Clinical Data and pre-clinical data and (b) the date that is six 
months from the Effective Date of the License.

TRANSACTION GIVING RISE TO THE EXCHANGE RIGHT

The Company and BGDC are pursuing a private placement transaction (the 
"Transaction") to fund the development of BG and to provide capital resources 
for the Company to develop its other products. As of the date of the mailing 
of this Proxy Statement, the Company and BGDC have sold approximately $3.0 
million of a class of Preferred Stock of BGDC (the "BGDC Preferred Stock") 
convertible into shares of BGDC common stock, and plan to sell up to an 
additional $7.0 million of the BGDC Preferred Stock in the Transaction. The 
Company receives approximately 25% of the proceeds of the Transaction with 
the remaining 75% going directly to BGDC. Any offer and sale of securities in 
the Transaction have been and will be made in reliance on an exemption from 
registration under the Securities Act of 1933, as amended, and the rules and 
regulations promulgated thereunder. The Company cannot predict when or if 
additional closings of the Transaction will occur.

In accordance with the terms of the Transaction, each holder of the BGDC 
Preferred Stock and the Company enter into agreements providing each holder 
with the right to exchange their BGDC Preferred Stock with the Company to the 
extent that any shares of the BGDC Preferred Stock are outstanding on the 
date that is one year following the final closing date of the Transaction 
(the "Initial Exchange Date"). In accordance with terms of such agreements, 
(i) for the 60-day period following the Initial Exchange Date, each holder of 
the BGDC Preferred Stock has the right to sell their shares of the BGDC 
Preferred Stock to the Company for $2.00 per share, and (ii) for the 60-day 
period following the one year anniversary of the Initial Exchange Date (the 
"Final Exchange Date"), each holder of the BGDC Preferred Stock has the right 
to put their shares of BGDC Preferred Stock to the Company for $3.99 per 
share (in either case the "Put Purchase Price"). The $2.00 Put Purchase Price 
is based upon the per share price of the BGDC Preferred Stock, and the $3.99 
Put Purchase Price is based upon the per share price plus accrued dividends 
at the time of the Final Exchange Date.


                                        13
<PAGE>

Importantly, the Company has the right, in its discretion, to pay the Put
Purchase Price in cash, the Company's Common Stock or any combination thereof.
In the event that the Company elects to pay the Put Purchase Price in shares of
Company Common Stock ("Exchange Shares"), the number of Exchange Shares to be
delivered will be determined by dividing (a) that portion of the Put Purchase
Price to be paid in Exchange Shares by (b) the average closing price of
Company's Common Stock for the 30 consecutive trading days immediately preceding
the Initial Exchange Date or the Final Exchange Date as the case may be, on the
principal national securities exchange on which Company's Common Stock is
admitted to trading or listed, or if not listed or admitted to trading on any
such exchange, the closing bid price of Company Common Stock as reported by the
NASDAQ, or other similar organization if NASDAQ is no longer reporting such
information, or, if the Company's Common Stock is not reported on NASDAQ, the
closing bid price for the Company's Common Stock in the over-the-counter market
as reported by the National Quotation Bureau or similar organization, or if not
so available, the fair market value of the Company's Common Stock as determined
in good faith between the Board of Directors of the Company and the holders of a
majority of the BGDC Preferred Stock then outstanding.


THIS PROXY STATEMENT IS NEITHER AN OFFER TO SELL NOR A SOLICITATION OF AN 
OFFER TO BUY ANY SECURITIES OF THE COMPANY, THE PROPOSED TO BE ISSUED 
SECURITIES REFERRED TO IN THIS PROXY STATEMENT HAVE NOT BEEN REGISTERED FOR 
SALE BY THE COMPANY UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE 
"SECURITIES ACT"), OR ANY STATE SECURITIES LAWS AND MAY NOT BE SO OFFERED OR 
SOLD ABSENT SUCH REGISTRATION UNDER THE SECURITIES ACT AND IN ACCORDANCE WITH 
APPLICABLE STATE SECURITIES LAWS OR ANY EXEMPTION FROM THE REGISTRATION 
REQUIREMENTS THEREOF.

STOCKHOLDER APPROVAL

Section 713 of the American Stock Exchange, Inc.'s ("AMEX") Listing 
Standards, Policies and Requirements sets forth certain stockholder approval 
requirements for companies with AMEX listed securities. In general, pursuant 
to Section 713, the Company is required to obtain stockholder approval prior 
to its issuance of Common Stock (or securities convertible into Common Stock) 
equal to 20% of the outstanding shares of Common Stock (the "20% Rule") at a 
price below the greater of the book value or market value of the Common 
Stock. On June 24, 1998, the Company was notified by AMEX that it intends to 
take actions to remove the Company's Common Stock from the AMEX because the 
Company fails to meet Amex's financial guidelines for continued listing. 
Although the Company intends to appeal Amex's decision, there can be no 
assurance that the Company will be able to maintain its AMEX listing. If the 
Company's appeal is not successful, it anticipates that its common stock will 
initially begin trading on the NASD Electronic Bulletin Board following 
removal from AMEX. Other exchanges, as well as the NASDAQ Stock Market, have 
requirements similar to that of the 20% Rule, although the NASD Bulletin 
Board does not presently impose any similar requirement. In order to comply 
with the 20% Rule or any such similar rule, the


                                        14
<PAGE>

prior approval of stockholders would be a condition precedent to the 
Company's consummation of any such transaction or transactions.

The Company is specifically seeking the Stockholders' approval to authorize 
the Company to enter into and perform agreements in connection with the 
Transaction and the Exchange Right, and in connection therewith, to use such 
amount of the Company's Common Stock that the Board of Directors determines 
to be appropriate, in its discretion, to satisfy the Put Purchase Price (such 
election by the Company, the "Exchange Right"), when and if the Put Right is 
exercised by any of the holders of the BGDC Preferred Stock.

Under certain circumstances, the Company's election to utilize the Exchange 
Right, and to issue shares of the Company's common stock to satisfy the Put 
Right, could result in the issuance of shares of Common Stock in excess of 
the 20% Rule. Ultimately, whether or not the 20% Rule is implicated by the 
Exchange Right would depend upon the price of the Company's Common Stock, the 
amount of BDGC Preferred Stock tendered pursuant to the Put Right, and how 
AMEX, if the Company's Common Stock is still listed on AMEX at the time of 
the Exchange Right were implemented, or any other exchange or market on which 
the Company's securities were then listed or reported would interpret the 20% 
Rule in relation to the Exchange Right at the time it was implemented. In any 
event, if the market price of the Company's Common Stock were low at the time 
the Exchange Right were implemented, and a substantial number of BDGC 
Preferred Stock shares tendered, substantial dilution could occur to the 
existing stockholders of the Company.

The Board of Directors believes that it is in the Company's best interests to 
consummate the Transaction and the Company intents to proceed with the 
Transaction whether or not the Exchange Right is approved by the Company's 
stockholders. In the event that stockholder approval is not obtained, the 
Company may have to pay cash to satisfy the Put Right, or the Board of 
Directors may, in consideration of its fiduciary duties, also determine to 
proceed with the Exchange Right if they determine such action to be in the 
Company's best interests. In such instance, the Company may no longer qualify 
for inclusion on the AMEX, if the Company's Common Stock is still listed on 
AMEX at the time of the Exchange Right were implemented or any other exchange 
or market on which the Company's securities were then listed that also 
applies the 20% Rule or any similar rule.

Although the issuance of shares of Common Stock pursuant to the Exchange 
Right as proposed herein could have a dilutive effect on the Company's 
current stockholders, the Board of Directors believes that stockholder 
approval of the issuance of such stock in the best interests of the Company. 
Approval of the Exchange Right will give the Company maximum flexibility to 
address the Put Right when and if it is exercised in the future. Accordingly, 
the Board of Directors strongly recommends that stockholders vote to approve 
the Exchange Right. The affirmative vote of the holders of a majority of the 
shares present in person or represented by proxy and entitled to vote at the 
meeting will be required to approve the foregoing proposal.


                                        15
<PAGE>

THE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR
IN FAVOR OF THE EXCHANGE RIGHT. PROXIES SOLICITED BY THE BOARD OF DIRECTORS WILL
BE VOTED IN FAVOR OF THE PROPOSAL UNLESS STOCKHOLDERS SPECIFY OTHERWISE.


                                   PROPOSAL 3

           RATIFICATION OF SELECTION OF INDEPENDENT PUBLIC ACCOUNTANTS

Although not required to do so, the Board customarily seeks stockholder 
ratification of its selection of Deloitte & Touche LLP to serve as the 
Company's independent public accountants for the fiscal year ending March 31, 
1999. Deloitte & Touche LLP has served as the Company's independent public 
accountants since 1983. It is anticipated that a representative of Deloitte & 
Touche LLP will attend the Meeting in person or by telephone, and will have 
an opportunity to make a statement if he or she desires to do so and will be 
available to respond to appropriate questions from stockholders.

THE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS THAT
THE STOCKHOLDERS VOTE FOR RATIFICATION OF DELOITTE & TOUCHE LLP
TO SERVE AS THE COMPANY'S INDEPENDENT PUBLIC ACCOUNTANTS
FOR THE FISCAL YEAR ENDING MARCH 31, 1999.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

As described above, in March of 1998 the Company entered into a license 
agreement for BG with the owners of the patents for BG and subsequently 
assigned its rights to BGDC. The Company and BGDC have entered into a 
one-year renewable Corporate Services and Management Agreement pursuant to 
which Pacific will provide financial/accounting, administrative, advisory and 
managerial support to BGDC and the Company will receive from BGDC a 
management fee of $500,000 per year, payable in monthly installments. The 
directors and officers of BGDC are: Dr. H. Laurence Shaw as Chairman, 
President and CEO, Anil K. Singhal as a director and Chief Scientific Officer 
and Michael S. Weiss as a director and Secretary.

In connection with the license agreement, the Company entered into an 
Introduction Agreement with Paramount Capital Investments, LLC, ("PCI"). The 
agreement provides for cash consideration of $100,000 plus reimbursement of 
expenses, as well as milestone payments in the Company's Common Stock of up 
to 1,000,000 shares if the BG compound successfully reaches certain 
milestones.

In connection with the Transaction, the Company, BGDC and a placement agent 
(the "Placement Agent") affiliated with Michael S. Weiss and certain 
significant stockholders of the Company have 


                                        16
<PAGE>

also entered into a placement agency agreement (the "Placement Agency 
Agreement") pursuant to which the Company and BGDC have agreed that BGDC will 
pay to the Placement Agent for its services, compensation in the form of (a) 
cash commissions equal to 9% of the gross proceeds from the Transaction, (b) 
a non-accountable expense allowance equal to 4% of the gross proceeds from 
the Transaction and (c) warrants to acquire a number of newly issued shares 
of BGDC Preferred Stock equal to 10% of the number of shares of BGDC 
Preferred Stock issued in the Transaction, exercisable for a period of 10 
years from the final closing date of the Transaction at 110% of the price per 
share of Preferred Stock sold in the Transaction.

In addition, upon the final closing date of the Transaction, BGDC and the 
Placement Agent will enter into an financial advisory agreement (the "BGDC 
Financial Advisory Agreement") whereby the Placement Agent will act as the 
non-exclusive financial advisor to BGDC for a period of 24 months. Such 
engagement will provide that the Placement Agent receive (a) a monthly 
retainer of $3,000, (b) out-of-pocket expenses and (c) success fees in the 
event Paramount or any of its affiliates assists BGDC in connection with 
certain financing and strategic transitions. In addition, upon the execution 
of the BGDC Financial Advisory Agreement, BGDC will sell to the Placement 
Agent and/or its designees, for $.001 per warrant, warrants to acquire a 
number of newly issued Units equal to 15% of the Units issued in the 
Offering, exercisable for a period of five years commencing six months after 
the Final Closing Date at an exercise price equal to 110% of the initial 
offering price of the share of Preferred Stock.

Paramount Capital, Inc. ("Paramount") acted as placement agent for the 
Company on its November 1995 private placement (the "1995 Private Placement") 
and on its December 1996 private placement (the "1996 Private Placement"). 
Pursuant to its engagement in connection with the 1995 Private Placement, 
Paramount received the right to designate two nominees to the Board of 
Directors of the Company; Michael S. Weiss, a Senior Managing Director of 
Paramount, and Elliott H. Vernon were subsequently designated and elected to 
the Board of Directors. On November 27, 1995, Paramount and the Company 
entered into a financial advisory agreement (the "Company Financial Advisory 
Agreement") whereby Paramount agreed to act as non-exclusive financial 
advisor to the Company and to identify and negotiate potential acquisition 
candidates, investments or strategic alliances and pursuant to which 
Paramount receives a monthly retainer of $2,500. In connection with the 1996 
Private Placement, the parties agreed to extend the Company Financial 
Advisory Agreement for an additional eighteen (18) months. Additionally, the 
Company will pay a commission to Paramount of 6% of the gross proceeds 
received upon any exercise of the Company's outstanding Class A Warrants 
which were sold in the 1995 Private Placement and the 1996 Private Placement. 
David R. Walner, Associate Director of Paramount and has served as Secretary 
of the Company, without compensation, since December 1996.

Paramount is affiliated with certain significant stockholders of the Company, 
including the Aries Trust, a Cayman Islands Trust ("Aries Trust"), Aries 
Domestic Fund, L.P., a Delaware Corporation ("Aries Domestic") and Dr. 
Lindsay A. Rosenwald. Paramount is also affiliated with Paramount Capital 
Asset Management, Inc. ("PCAM") which is the investment manager of Aries 
Trust and the 


                                        17
<PAGE>

General Partner of Aries Domestic. Dr. Rosenwald is the sole stockholder of 
PCAM. Dr. Rosenwald is also Chairman and Michael S. Weiss is a Senior 
Managing Director of Paramount.

In June 1996 the Company entered into an agreement (the "BTI Agreement") with 
Binary Therapeutics, Inc. (BTI) under which the Company was granted an option 
to acquire BTI. If the Company elects to exercise its option, the agreement 
calls for the Company to issue 1,000,000 to 3,000,000 shares of Common Stock 
to the BTI stockholders, depending upon the price of the Company's Common 
Stock at the date of the closing. Mr. Weiss, a Director of the Company, is a 
Director and Secretary of BTI. Aries Trust, Aries Domestic and Dr. Rosenwald 
are also stockholders of BTI. Under the BTI Agreement, as amended, the 
Company is required to advance to BTI funds to repay $664,000 in indebtedness 
in the event that the Company exercises its option to acquire BTI. The 
holders of such indebtedness are Aries Trust, Aries Domestic and Dr. 
Rosenwald.

The Company and BTI have agreed to extend the period during which the Company 
may exercise its option to acquire BTI by a merger of BTI into a wholly owned 
subsidiary of the Company from April 30, 1997 until such time as BTI has 
completed human clinical trials of Boronated Porphyrin Compounds (BOPP) at an 
agreed upon dose level. The option period was extended at the Company's 
request to enable BTI to complete preclinical studies, to commence clinical 
trials in humans and to demonstrate that a given dose level of BOPP in humans 
would not cause certain adverse events. The Company believes that the 
extension of the option will give it greater opportunity to access the 
preliminary data resulting from the BOPP preclinical trials and the Phase I 
human clinical trials before determining whether to acquire BTI and to 
evaluate the possibility of adverse events in human patients. Accordingly, 
the Company has determined to defer exercise of the option and the 
stockholder vote therewith.

In April 1996, the Board of Directors approved a relocation package for Dr. 
H. Laurence Shaw, which included payment of all of Dr. Shaw's relocation 
expenses and an interest free bridge loan of $300,000 for Dr. Shaw to use to 
acquire a new residence in California. The loan, which was made in May 1997, 
was paid back in September 1997. The Company incurred $182,000 in relocation 
expenses for Dr. Shaw's move.

             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

Section 16(a) of the Exchange Act requires the Company's Directors and 
executive officers, and persons who own more than ten percent of a registered 
class of the Company's equity securities, to file with the SEC initial 
reports of ownership and reports of changes in ownership of Common Stock and 
other equity securities of the Company. Officers, Directors and greater than 
ten percent stockholders are required by SEC regulation to furnish the 
Company with copies of all Section 16(a) forms they file.

To the Company's knowledge, based solely on a review of the copies of such 
reports furnished to the Company and written representations that no other 
reports were required, and reliance by the Company upon such reports and 
representations, during the fiscal year ended March 31, 1998, all 


                                        18
<PAGE>

Section 16(a) requirements applicable to its officers, directors and greater 
than ten percent beneficial owners were complied with.

                        DESCRIPTION OF COMPANY SECURITIES

AUTHORIZED STOCK

The authorized capital stock of the Company consists of 100,000,000 shares of 
Common Stock and 2,000,000 shares of Preferred Stock. The following 
descriptions of securities is not complete and is qualified in all respects 
by the Company's Certificate of Incorporation, as amended, Certificates of 
Designations and Warrant Agreements, respectively, the forms of which are 
filed as exhibits to the Company's filings with the Commission.

COMMON STOCK

There are outstanding 11,257,021 shares of Common Stock owned of record by 
approximately 425 holders at June 26, 1998. The holders of Common Stock (i) 
have equal and ratable rights to dividends from funds legally available 
therefor, when, as and if declared by the Board of Directors of the Company; 
(ii) are entitled to share ratably in all assets of the Company available for 
distribution to holders of Common Stock upon liquidation, dissolution or 
winding up of the affairs of the Company; and (iii) do not have preemptive or 
subscription rights. There are no redemption or sinking fund provisions 
applicable to the Common Stock. Each holder of Common Stock is entitled to 
one vote per share for all purposes. The Board of Directors is authorized to 
issue additional shares of Common Stock within the limits authorized by the 
Company's Certificate of Incorporation, as amended, without stockholder 
action.

PREFERRED STOCK

The Company's Certificate of Incorporation authorizes the Board of Directors, 
without further vote or action by stockholders, to issue shares of Preferred 
Stock in one or more series and to determine the rights, preferences, 
privileges and restrictions thereof, including the dividend rights, dividend 
rate, conversion rights, voting rights, terms of redemption (including 
sinking fund provisions), redemption price or prices, liquidation preferences 
and the number of shares constituting any series or the designations of such 
series. These rights and privileges could limit the voting power of holders 
of Common Stock and restrict their rights to receive dividends or liquidation 
proceeds in an adverse manner.

The Company has granted the Board of Directors authority to issue Preferred 
Stock and to determine its rights and preferences to eliminate delays 
associated with a stockholder vote on specific issuances. The Company 
believes that this power to issue Preferred Stock will provide flexibility in 
connection with possible corporate transactions. It could also have the 
effect, however, of making it more difficult for a third party to acquire, or 
of discouraging a third party from attempting to acquire, control of the 
Company. See "Stockholders' Rights Plan."


                                        19
<PAGE>

The Board of Directors has authorized the issuance of up to 56,250 shares of 
Convertible Preferred Stock to be designated as the Company's Series A 
Convertible Preferred Stock (the "Convertible Preferred Stock"). There are 
outstanding 38,446 shares of Convertible Preferred Stock, owned of record by 
69 holders at June 26, 1998. The rights, preferences and characteristics of 
the Convertible Preferred Stock are as follows:

DIVIDENDS

The holders of Convertible Preferred Stock will be entitled to receive 
dividends as, when and if declared by the Board of Directors out of funds 
legally available therefor. No dividend or distribution, as the case may be, 
shall be declared or paid on any junior stock unless first the holders of the 
Convertible Preferred Stock are paid a special dividend in the amount of $260 
per share, and the same dividend as proposed to be paid to the junior stock 
is also paid to the Convertible Preferred Stock. The Company does not intend 
to pay cash dividends on the Convertible Preferred Stock or the underlying 
Common Stock for the foreseeable future.

CONVERSION

Each share of Convertible Preferred stock may be converted at the option of 
the holder at any time after the initial issuance date into Common Stock at a 
conversion price of 290.89 shares of Common Stock for each share of 
Convertible Preferred Stock.

MANDATORY CONVERSION

The Company has the right to cause the Convertible Preferred Stock to be 
converted in whole or in part, on a PRO RATA basis, into shares of Common 
Stock if the closing price of the Common Stock exceeds 200% of the conversion 
price for at least 20 trading days in any 30 consecutive trading day period.

LIQUIDATION

Upon (i) a liquidation, dissolution or winding up of the Company, whether 
voluntary or involuntary, (ii) a sale or other disposition of all or 
substantially all of the assets of the Company or (iii) any consolidation, 
merger, combination, reorganization or other transaction in which the 
Corporation is not the surviving entity or in which shares of Common Stock 
constituting in excess of 50% of the voting power of the Corporation are 
exchanged for or changed into other stock or securities, cash or any other 
property, after payment or provision for payment of the debts and other 
liabilities of the Company, the holders of the Convertible Preferred Stock 
then outstanding will first be entitled to receive, PRO RATA (on the basis of 
the number of shares of the Convertible Preferred Stock then outstanding), 
and in preference of the holders of the Common Stock and any other series of 
preferred stock, an amount per share equal to $260.00 plus accrued but unpaid 
dividends, if any.


                                        20
<PAGE>

VOTING RIGHTS

The holders of the Convertible Preferred Stock have the right at all meetings 
of stockholders to the number of votes equal to the number of shares of 
Common Stock issuable upon conversion of the Convertible Preferred Stock at 
the record date for determination of the stockholders entitled to vote. So 
long as a majority of the shares of Convertible Preferred Stock remain 
outstanding, the holders of 66.67% of the Convertible Preferred Stock then 
outstanding are entitled to approve (i) the issuance of any securities of the 
Company senior to or on parity with the Convertible Preferred Stock; (ii) any 
alteration or change in the rights, preferences or privileges of the 
Convertible Preferred Stock; and (iii) the declaration of payment of any 
dividend on any junior stock or the repurchase of any junior securities of 
the Company. Except as provided above or as required by applicable law, the 
holders of the Convertible Preferred Stock will be entitled to vote together 
with the holders of the Common Stock and not as a separate class.

CLASS A WARRANTS

EXERCISE PRICE AND TERMS

Each Class A Warrant entitles the holder there of to purchase one share of 
Common Stock at a price of $1.00 per share subject to adjustment in 
accordance with the adjustment provisions set forth in the Warrant Agreement 
summarized below. The Class A Warrants may be exercised upon surrender of the 
Class A Warrant certificate on or prior to November 26, 2005 (or, if redeemed 
prior thereto, the date immediately preceding the redemption date) at the 
offices of the Warrant Agent, with the subscription form on the reverse side 
of the Warrant certificate completed as indicated, accompanied by payment of 
the full exercise price (by cashier's or certified check payable to the order 
of the Warrant Agent, or by wire transfer) for the number of Class A Warrants 
being exercised. No fractional shares will be issued upon the exercise of the 
Class A Warrants, and the Company will pay cash in lieu of fractional shares.

ADJUSTMENT

The exercise price and the number of shares of Common Stock purchasable upon 
the exercise of the Class A Warrants are subject to adjustments upon the 
occurrence of certain events, such as stock dividends or stock splits of the 
Common Stock. Additionally, an adjustment would be made in the case of the 
reclassification or exchange of the Common Stock, consolidation or merger of 
the Company with or into another corporation or sale of all or substantially 
all of the assets of the Company, in order to enable Class A Warrant holders 
to acquire the kind and number of shares of stock or other securities or 
property receivable in such event by holders of the number of shares of 
Common Stock that might otherwise have been purchased upon the exercise of 
the Class A Warrant. No adjustment to the exercise price of the shares 
subject to the Class A Warrants will be made for dividends (other than 
dividends in the form of stock), if any, paid on the Common Stock.


                                        21
<PAGE>

REDEMPTION

The Class A Warrants are subject to redemption by the Company at $.10 per 
warrant on 60 days' prior written notice provided that the closing bid 
quotation for the Common Stock as reported on the AMEX, or on such exchange 
on which the Common Stock is then traded, exceeds 400% of the exercise price 
per share for 20 consecutive trading days ending three days prior to the date 
of redemption.

WARRANT HOLDER NOT A STOCKHOLDER

The Class A Warrants do not confer upon holders thereof any voting or any 
other rights of a stockholder of the Company. The shares of Common Stock 
issuable upon exercise of the Class A Warrants in accordance with the terms 
thereof will be fully paid and nonassessable.

SETTLEMENT WARRANTS

The Board of Directors authorized the issuance of 309,734 Settlement 
Warrants, to be designated as the Company's Series B Warrants, in settlement 
of a class-action lawsuit against the Company. Class B Warrants are owned of 
record by 588 holders at June 26, 1998.

EXERCISE PRICE AND TERMS

Each Class B Warrants entitles the holder thereof to purchase one share of 
Common Stock at a price of $22.00 per share subject to adjustment in 
accordance with the adjustment provisions set forth in the Warrant Agreement 
summarized below. The Class B Warrants may be exercised at any time prior to 
August 11, 2001. No fractional shares will be issued upon the exercise of the 
Class B Warrants, and the Company will pay cash in lieu of fractional shares. 
After August 12, 2001, the Class B Warrants will become void and of no value.

ADJUSTMENT

The exercise price and the number of shares of Common Stock purchasable upon 
the exercise of the Class B Warrants are subject to adjustments upon the 
occurrence of certain events, such as stock dividends or stock splits of the 
Common Stock. Additionally, an adjustment would be made in the case of the 
reclassification or exchange of the Common Stock, consolidation or merger of 
the Company with or into another corporation or sale of all or substantially 
all of the assets of the Company, in order to enable Class B Warrant holders 
to acquire the kind and number of shares of stock or other securities or 
property receivable in such event by holders of the number of shares of 
Common Stock that might otherwise have been purchased upon the exercise of 
the Class B Warrant. No adjustment to the exercise price of the shares 
subject to the Class B Warrants will be made for dividends (other than 
dividends in the form of stock), if any, paid on the Common Stock.


                                        22
<PAGE>

WARRANT HOLDER NOT A STOCKHOLDER

The Class B Warrants do not confer upon holders thereof any voting or any 
other rights of a stockholder of the Company. The shares of Common Stock 
issuable upon exercise of the Class B Warrants in accordance with the terms 
thereof will be fully paid and nonassessable.

STOCKHOLDERS' RIGHTS PLAN

In April 1991, the Company's Board of Directors adopted a stockholders' 
rights plan (the "Plan"). The Plan provides for the distribution of preferred 
stock purchase rights to common stockholders which separate from the Common 
Stock ten business days following: (a) an announcement of an acquisition by a 
person (or group) ("Acquiring Party") of 15% or more of the outstanding 
shares of Common Stock of the Company, (b) the commencement of a tender offer 
or exchange offer for 15% or more of the Common Stock or (c) a merger or 
asset sale as defined in the Plan. Under the Plan, certain related parties 
are not considered to be an Acquiring Party. In addition, the Plan was 
amended in December 1996 to allow the Placement Agent (and affiliates) to 
acquire an unlimited amount of the outstanding Common Stock without being 
characterized as an Acquiring Party. One right attached to each share of 
Common Stock outstanding as of April 15, 1991 and attaches to all shares 
issued thereafter. Each right entitles the holder to purchase one 
one-hundredth of one share of Series R junior participating cumulative 
preferred stock, par value $25.00 per share ("Unit of Preferred Stock"), at 
an exercise price of $120 per Unit of Preferred Stock. The Units of Preferred 
Stock are non redeemable, voting and are entitled to certain preferential 
dividend and liquidation rights. The exercise price and the number of Units 
of Preferred Stock issuable are subject to adjustment to prevent dilution.

If, after the rights have been distributed, the Company is a party to a 
business combination or other specifically defined transaction, each right 
(other than those held by the Acquiring Party) will entitle the holder to 
receive, upon exercise, Units of Preferred Stock or shares of common stock of 
the surviving company with a value equal to two times the exercise price of 
the right. Alternatively, a majority of the independent Directors of the 
Company may direct the Company to exchange all of the then outstanding rights 
for Common Stock at an exchange ratio of one share of Common Stock per right. 
The rights expire April 15, 2001 and are redeemable (at the option of a 
majority of the independent Directors of the Company) at $.01 per right at 
any time until the tenth day following an announcement of the acquisition of 
15% or more of the Company's Common Stock.

TRANSFER AND WARRANT AGENT

The transfer agent for the Common Stock, Series A Convertible Preferred 
Stock, Class A Warrants and Settlement Warrants is the American Stock 
Transfer and Trust Company, 6201 15th Avenue, 3rd Floor, Brooklyn, New York 
11219.


                                        23
<PAGE>

                         DESCRIPTION OF BGDC SECURITIES

AUTHORIZED STOCK

The authorized capital stock of BGDC consists of 25,000,000 shares of Common
Stock, par value $.001, per share (the "BGDC Common Stock"), and 10,000,000
shares of Preferred Stock, par value $.001, per share.

COMMON STOCK

As of June 26, 1998, there are outstanding 7,500,000 shares of BGDC Common 
Stock, all owned by the Company. The holders of BGDC Common Stock (i) have 
equal and ratable rights to dividends from funds legally available therefor, 
when, as and if declared by the Board of Directors of BGDC; (ii) are entitled 
to share ratably in all assets of BGDC available for distribution to holders 
of BGDC Common Stock upon liquidation, dissolution or winding up of the 
affairs of BGDC; and (iii) do not have preemptive or subscription rights. 
There are no redemption or sinking fund provisions applicable to the BGDC 
Common Stock. Each holder of BGDC Common Stock is entitled to one vote per 
share for all purposes. The Board of Directors of BGDC is authorized to issue 
additional shares of BGDC Common Stock within the limits authorized by the 
BGDC's Certificate of Incorporation, as amended, without stockholder action.

PREFERRED STOCK

BGDC's Certificate of Incorporation authorizes its Board of Directors, 
without further vote or action by stockholders, to issue shares of Preferred 
Stock in one or more series and to determine the rights, preferences, 
privileges and restrictions thereof, including the dividend rights, dividend 
rate, conversion rights, voting rights, terms of redemption (including 
sinking fund provisions), redemption price or prices, liquidation preferences 
and the number of shares constituting any series or the designations of such 
series. These rights and privileges could limit the voting power of holders 
of BGDC Common Stock and restrict their rights to receive dividends or 
liquidation proceeds in an adverse manner.

BGDC has granted the Board of Directors authority to issue Preferred Stock 
and to determine its rights and preferences to eliminate delays associated 
with a stockholder vote on specific issuances. BGDC has no outstanding shares 
of Preferred Stock and no present plans to issue any shares of Preferred 
Stock other than the BGDC Preferred Stock described below.

The Board of Directors has authorized the issuance of up to 7,000,000 shares 
of Convertible Preferred Stock to be designated as BGDC's Series A 
Convertible Preferred Stock (the "BGDC Preferred Stock"). The rights, 
preferences and characteristics of the BGDC Preferred Stock are as follows:


                                        24
<PAGE>

VOTING RIGHTS

The holders of BGDC Preferred Stock will have the right at all meetings of 
its stockholders to that number of votes in respect of such BGDC Preferred 
Stock equal to the number of shares of BGDC Common Stock issuable upon 
conversion of such shares of BGDC Preferred Stock at the record date for the 
determination of the stockholders entitled to vote on matters or, if no such 
record date is established, at the date such vote is taken. Unless otherwise 
expressly provided by the Certificate of Incorporation or required by 
applicable law, the holders of Preferred Stock will vote together with the 
holders of BGDC Common Stock and not as a separate class.

In addition, any amendment to the Certificate of Incorporation of BGDC that 
(a) adversely affects the conversion terms of the BGDC Preferred Stock or (b) 
creates a class of capital stock that has rights senior to the BGDC Preferred 
Stock upon a Liquidation Event (as defined below) or a Merger Event (as 
defined below) or with respect to voting power (as to matters other than 
relating solely to such class of capital stock), shall require the approval 
of the holders of a majority of the BGDC Preferred Stock, except that BGDC 
may issue additional shares of BGDC Preferred Stock and/or preferred stock 
with rights similar to those of the BGDC Preferred Stock.

DIVIDENDS

At all times while the BGDC Preferred Stock remains outstanding, the BGDC 
Preferred Stock shall accrue dividends (the "Preferred Dividends") payable 
out of funds legally available therefor as follows:

<TABLE>
<CAPTION>
                      Dividend Date                                     Dividend Amount
                      -------------                                     ---------------
<S>                                                                     <C>
On the date of the final closing date of the
   Transaction (the "Final Closing Date")............................   $1.99 per share
On the date that is 30 months from the Final Closing Date............   $0.82 per share
On the date that is 36 months from the Final Closing Date............   $0.82 per share
On the date that is 42 months from the Final Closing Date............   $1.16 per share
On the date that is 48 months from the Final Closing Date............   $1.16 per share
</TABLE>

Thereafter, at all times while the BGDC Preferred Stock remains outstanding, 
the holders of BGDC Preferred Stock shall be entitled to receive an annual 
dividend at an annual rate of 35%, compounded monthly.

The Preferred Dividends shall be payable only when, as and if declared by the 
Board of Directors. The Board of Directors does not presently intend to 
declare or pay any Preferred Dividends. Preferred Dividends not declared and 
paid when due shall accrue, accumulate and be included in the liquidation 
preference of the BGDC Preferred Stock and shall be canceled upon conversion.


                                        25
<PAGE>

In addition to the foregoing, the holders of the BGDC Preferred Stock shall 
be entitled to receive dividends when, as and if declared by the Board of 
Directors out of funds legally available therefor. BGDC shall not declare any 
dividend or distribution on any securities ranking junior to the BGDC 
Preferred Stock ("Junior Stock") unless and until a special dividend equal to 
the Liquidation Amount has been declared and paid on the BGDC Preferred Stock 
and all accrued and unpaid dividends have been paid on the BGDC Preferred 
Stock.

CONVERSION

The BGDC Preferred Stock may be converted at the option of the holder at any 
time after the initial issuance date of the BGDC Preferred Stock at the then 
applicable Conversion Price for fully paid and nonassessable shares of BGDC 
Common Stock. The Conversion Price of the BGDC Preferred Stock, initially 
$2.00 per share of Common Stock, is subject to adjustment upon the occurrence 
of issuances of securities at below market price or below the Conversion 
Price, a merger, reorganization, consolidation, reclassification, stock 
dividend or stock split which will result in an increase or decrease in the 
number of shares of BGDC Common Stock outstanding.

The BGDC Preferred Stock shall be automatically converted into BGDC Common 
Stock on the date (the "Conversion Date") that is six months after the first 
date (the "Trading Date") on which the BGDC Common Stock (or securities 
received by all holders of BGDC Common Stock in exchange for BGDC Common 
Stock) trades on a national securities exchange or on the National 
Association of Securities Dealers, Inc. Automated Quotation System 
(collectively "NASDAQ") (a "Trading Event"). The Conversion Price will be 
adjusted downward if the Trading Price (as defined below) as of the 
Conversion Date is less than the then applicable Liquidation Amount per share 
(an "Adjustment Event") so that upon an Adjustment Event, each share of BGDC 
Preferred Stock shall be automatically converted into shares of BGDC Common 
Stock at a Conversion Price equal the greater of (a) the Trading Price 
divided by the applicable Return Factor (as defined below) and (b) 25% of the 
then applicable Conversion Price.

The "Return Factor" shall equal the quotient obtained by dividing (x) the 
Liquidation Amount per share by (y) the per share stated value of the BGDC 
Preferred Stock. The "Trading Price" shall mean the lower of (i) the average 
closing bid price of the Common Stock (with appropriate adjustments for 
subdivisions or combinations of shares effected during such period) for 30 
consecutive trading days, ending with the trading day prior to the date as of 
which the Trading Price is being determined, and (ii) the average closing bid 
price of the Common Stock (with appropriate adjustments for subdivisions or 
combinations of shares effected during such period) for five consecutive 
trading days, ending with the trading day prior to the date as of which the 
Trading Price is being determined, provided that if the prices referred to in 
the definition of closing bid price cannot be determined for any of such 
periods, "Trading Price" shall mean Fair Market Value (as defined Certificate 
of Designation attached hereto as Exhibit B).

In addition, each share of BGDC Preferred Stock shall be automatically converted
immediately prior to an underwritten initial public offering of BGDC Common
Stock in which gross proceeds to 


                                        26
<PAGE>

BGDC exceed $5,000,000 (a "Qualified IPO") pursuant to an effective 
registration statement under the Securities Act (a "Reset Event") on the date 
of the Reset Event (the "Reset Date") at a conversion price that will ensure, 
subject to the limitations described below, that each share of BGDC Preferred 
Stock is convertible into that number of shares of BGDC Common Stock such 
that when multiplied by the Reset Price (as defined below), each share of 
Preferred Stock shall be valued at least at the Liquidation Amount (subject 
to equitable adjustments for stock splits and other similar events). 
Accordingly, the aggregate number of shares of BGDC Common Stock issuable 
upon conversion of the BGDC Preferred Stock is subject to adjustment (the 
"Reset Adjustment") at the time of the Reset Event, if the PMV (as defined 
below) is less than the Minimum Value (as defined below). In such event, the 
conversion ration of the BGDC Preferred Stock shall be increased to equal a 
ratio that will provide that the issued and outstanding shares of BGDC 
Preferred Stock (assuming exercise or conversion of the Preferred Stock 
Equivalents (as defined below) into shares of BGDC Preferred Stock) shall in 
the aggregate be convertible into a number of shares of BGDC Common Stock 
equal to the product of (A) the Pre-Reset Shares (as defined below) times (B) 
a fraction, the numerator which is the Aggregate Liquidation Amount (as 
defined below) and the denominator of which is the PMV. No adjustment shall 
be made if the PMV is greater than the Minimum Value.

Any Reset Adjustment will be subject to the limitations that (a) in no event 
shall the adjusted conversion ratio entitle the holders of the BGDC Preferred 
Stock to hold in excess of 80% of the Pre-Reset Shares and (b) BGDC may offer 
similar (but not more favorable) protection to investors in a Subsequent 
Offering without the consent of the holders of the BGDC Preferred Stock 
provided that any reduction in the Pre-Reset Shares allocable to the holders 
of the BGDC Preferred Stock or the holders of the Subsequent offering 
Securities (as defined below), as the case may be, are allocated first from 
the Pre-Reset Shares to be allocated to the holders of BGDC Common Stock and 
BGDC Common Stock Equivalents (but subject to the 80% limitation described in 
(a) above) and secondly out of the Pre-Reset Shares to be held by the holders 
of the Preferred Stock or the holders of the Subsequent Offering Securities, 
as the case may be, pro rata based upon the relative amounts of the Offering 
Amount and the Subsequent Offering Amount.

For purposes of the foregoing:

         (A) "The Aggregate Liquidation Amount" shall mean the aggregate
         Liquidation Amount of outstanding shares of BGDC Preferred Stock
         (assuming exercise or conversion of all Preferred Stock Equivalents
         into BGDC Preferred Stock);

          (B) "BGDC Common Stock Equivalents" shall mean all securities
         exercisable for or convertible into, directly or indirectly, shares of
         BGDC Common Stock excluding shares issuable upon conversion of the BGDC
         Preferred Stock and Preferred Stock Equivalents or any Subsequent
         Offering Securities;

         (C) "Unadjusted Percentage" shall mean the quotient of (1) all shares
         of BGDC Common Stock issuable upon the exercise and/or conversion of
         all BGDC Preferred Stock and Preferred Stock Equivalents, prior to any
         adjustments as a result of a Reset Event, divided 


                                        27
<PAGE>

         by (2) all outstanding shares of BGDC Common Stock and all shares of 
         BGDC Common Stock issuable upon the exercise or conversion of all 
         outstanding BGDC Common Stock Equivalents plus all shares of BGDC 
         Common Stock issuable upon conversion of the BGDC Preferred Stock and 
         Preferred Stock Equivalents, in each case prior to any adjustments as 
         a result of the Reset Event;

         (D) "Minimum Value" shall mean the quotient obtained by dividing (1)
         the sum of the Aggregate Liquidation Amount by (2) the Unadjusted
         Percentage;

         (E) "Pre-Reset Shares" shall mean the aggregate number of shares of
         BGDC Common Stock outstanding on a fully diluted basis (assuming the
         exercise or conversion of all BGDC Common Stock Equivalents and
         including shares of BGDC Common Stock issuable upon conversion of the
         BGDC Preferred Stock and Preferred Stock Equivalents or any Subsequent
         Offering Securities) upon the effectiveness of the Reset Event, but
         excluding shares of BGDC Common Stock and BGDC Common Stock Equivalents
         issued in or at the time of the Reset Event as a result of a Reset
         Event;

         (F) "Preferred Stock Equivalents" shall mean all securities exercisable
         for, or convertible into, shares of BGDC Preferred Stock;

         (G) "PMV" shall be equal to the aggregate value of the Pre-Reset Shares
         determined by multiplying the number of Pre-Reset Shares by the Reset
         Price;

         (H) "Reset Price' shall mean the per share public offering price of the
         BGDC Common Stock sold in the Qualified IPO. If units of BGDC Common
         Stock and other securities are issued in the Qualified IPO, the Board
         of Directors of BGDC shall in good faith allocate value to the BGDC
         Common Stock based on the relative historical values of similar unit
         offerings conducted by the same and/or similar underwriters;

         (I) "Offering Amount" shall mean the gross amount of proceeds to BGDC
         from sales of the then outstanding shares of Preferred Stock ($2.00 per
         share in the case of the Transaction) plus any other amounts receivable
         by BGDC in connection with the issuance of shares of the BGDC Preferred
         Stock upon conversion or exercise of any then outstanding securities
         convertible or exercisable, directly or indirectly, for the BGDC
         Preferred Stock;

         (J) "Subsequent Offering" shall mean any private financing of debt
         securities or series of preferred stock of BGDC that shall in each case
         by convertible, directly or indirectly, into shares of BGDC Common
         Stock which shall be consummated by BGDC prior to the Qualified IPO;

         (K) "Subsequent Offering Amount" shall mean the gross amount of
         proceeds or other amounts received or receivable by BGDC in any
         Subsequent Offering of Subsequent Offering Securities; and


                                        28
<PAGE>

         (L) "Subsequent Offering Securities" shall mean the convertible debt
         securities or convertible preferred stock of BGDC issued in any
         Subsequent Offering that have the Reset Event protection.

LIQUIDATION PREFERENCE

Upon a liquidation, dissolution or winding up of BGDC, whether voluntary or 
involuntary (a "Liquidation Event"), after payment or provision for payment 
of the debts and other liabilities of BGDC, subject to the prior and superior 
rights of the holders of any shares of any series or class of capital stock 
ranking prior and superior to the shares of the BGDC Preferred Stock with 
respect to liquidation, holders of the BGDC Preferred Stock will receive, pro 
rata (on the basis of the number of shares of Preferred Stock then 
outstanding), in preference to the holders of all other series of preferred 
stock (other than shares of preferred stock that are pari passu with the BGDC 
Preferred Stock) and BGDC Common Stock, $2.00 per share (subject to 
appropriate adjustments for stock splits and other similar events) plus 
declared but unpaid dividends, if any, and all accrued but unpaid Preferred 
Dividends (collectively, the "Liquidation Amount"). Similar treatment for the 
holders of the BGDC Preferred Stock will be provided upon (a) any 
consolidation, merger, combination, reorganization or other transaction in 
which BGDC is not the surviving entity or the shares of BGDC Common Stock 
constituting in excess of 50% of the voting power of BGDC are exchanged for 
or changed into other stock or securities (other than pursuant to the 
Exchange Right described below), cash and/or any other property or (b) a sale 
or other disposition of all or substantially all of the assets of BGDC (any 
of the foregoing a "Merger Event"). The Liquidation Amount is payable in cash 
or securities.

EXCHANGE RIGHT

To the extent that any shares of BGDC Preferred Stock are outstanding on the 
date that is one year following the Final Closing Date (the "Initial Exchange 
Date"), then, (i) for the 60 day period thereafter, the holders of BGDC 
Preferred Stock will have the right to put their shares of BGDC Preferred 
Stock, if any, to Pacific Pharmaceuticals, Inc. for $2.00 per share, and (ii) 
for the 60-day period following the one year anniversary of the Initial 
Exchange Date (the "Final Exchange Date"), each holder of the BGDC Preferred 
Stock would have the right to put their shares of BGDC Preferred Stock to the 
Company for $3.99 per share (in each case subject to adjustments for stock 
splits and other similar events) (the "Exchange Purchase Price").

The Exchange Purchase Price may be paid in cash, Company Common Stock or any 
combination thereof, at the Company's sole discretion, within 60 days after 
the holder's exercise of the put right.

In the event that the Company elects to pay the Purchase Price in shares of 
Company Common Stock ("Exchange Shares"), the number of Exchange Shares to be 
delivered will be determined by dividing (a) that portion of the Exchange 
Purchase Price to be paid in Exchange Shares by (b) the average closing price 
of Company's Common Stock for the 30 consecutive trading days immediately 


                                        29
<PAGE>

preceding the Initial Exchange Date or the Final Exchange Date, as the case 
may be, on the principal national securities exchange on which Company's 
Common Stock is admitted to trading or listed, or if not listed or admitted 
to trading on any such exchange, the closing bid price of Company Common 
Stock as reported by the NASDAQ, or other similar organization if NASDAQ is 
no longer reporting such information, or, if the Company's Common Stock is 
not reported on NASDAQ, the closing bid price for the Company's Common Stock 
in the over-the-counter market as reported by the National Quotation Bureau 
or similar organization, or if not so available, the fair market value of the 
Company's Common Stock as determined in good faith between the Board of 
Directors of the Company and the holders of a majority of the BGDC Preferred 
Stock then outstanding.

REDEMPTION

BGDC shall have the right at any time following the date of issuance of the BGDC
Preferred Stock to redeem the BGDC Preferred Stock in whole, but not in part,
upon not less than 30 days nor more than 60 days written notice, at a price
equal to the Liquidation Amount. The Holders of the BGDC Preferred Stock will
have the right, on or prior to the redemption date specified in the written
notice by BGDC, to convert each share of the BGDC Preferred Stock into shares of
the BGDC Common Stock at the then applicable conversion ratio.

                             STOCKHOLDERS' PROPOSALS

Proposals of stockholders which are intended to be presented at the 1999 Annual
Meeting must be consistent with the regulations of the SEC and received by the
Company at its principal executive offices not later than February 28, 1999 for
inclusion in the Company's proxy materials for that meeting. Such proposals
should be directed to Pacific Pharmaceuticals, Inc., Attention: Investor
Relations, at the address shown on Page 1.

                                 OTHER BUSINESS

At the date of this Proxy Statement, the Company knows of no other matters to be
brought before the Meeting. If other matters should properly come before the
Meeting, it is the intention of each person mentioned in the proxy to vote such
proxy in accordance with his judgment of such matters. Discretionary authority
with respect to such other matters is granted by the execution of the enclosed
proxy.




                                        30
<PAGE>

                    REQUEST TO VOTE, SIGN AND RETURN PROXIES

PLEASE VOTE, DATE AND SIGN THE ENCLOSED PROXY CARD AND RETURN IT IN THE 
ACCOMPANYING ENVELOPE AT YOUR EARLIEST CONVENIENCE.

DATED:  JULY 8, 1998

                                         BY ORDER OF THE BOARD OF DIRECTORS

                                         BY: /S/ H. LAURENCE SHAW, M.D.
                                             --------------------------
                                                 H. LAURENCE SHAW, M.D.



                                        31
<PAGE>
                           PACIFIC PHARMACEUTICALS, INC.
                                          
                                       PROXY
                                          
                          ANNUAL MEETING, AUGUST 13, 1998
                                          
            THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The undersigned hereby appoints H. Laurence Shaw and James Hertzog as
Proxies, each with full power to appoint his substitute, and hereby authorizes
them to appear and vote as designated below, all shares of Common Stock and
Series A Convertible Preferred Stock of Pacific Pharmaceuticals, Inc. held on
record by the undersigned on June 26, 1998, at the Annual Meeting of
Stockholders to be held on August 13, 1998, and any adjournment thereof.

     The undersigned hereby directs this proxy to be voted: 

Please mark your vote
as in this example:      /X/

<TABLE>
<CAPTION>
                                                                                               WITHHOLD
                                                                                   FOR ALL       ALL        WITHHOLD
                                                                                   NOMINEES    NOMINEES     AUTHORITY
<S>  <C>                                                                           <C>         <C>          <C>
1.   Election of Directors    Nominees:      H. Laurence Shaw                        / /         / /           / /
                                             Jack Halperin
                                             John G. Kringel
                                             Elliott H. Vernon
                                             Robert A. Vukovich
                                             Michael S. Weiss

     For, except vote withheld from the following nominee(s):

     ---------------------------------------------


                                                                                    FOR         AGAINST        ABSTAIN

2.   To authorize the Company to enter into agreements, in connection with a        / /           / /            / /
     private placement financing by the Company and the Company's subsidiary, 
     BG Development Corp. ("BGDC"), to exchange shares of BGDC Convertible
     Preferred Stock for shares of the Company's Common Stock under certain
     circumstances.


3.   To ratify the Board of Directors' selection of Deloitte & Touche LLP as the    / /           / /            / /
     Company's independent public accountants for the year ended March 31, 1999.


4.   To consider and act on such other business as may properly be presented at
     the Meeting.
</TABLE>



                       (CONTINUED, AND TO BE SIGNED AND DATED, ON REVERSE SIDE)



     In their discretion, the named Proxies may vote on such other business as
may properly come before the Annual Meeting, or any adjournments or
postponements thereof.

     THIS PROXY, WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER.  IF NO DIRECTIONS IS MADE, THIS PROXY
WILL BE VOTED FOR PROPOSALS 1, 2 AND 3.

<PAGE>

     SHARES REPRESENTED BY THIS PROXY WILL BE VOTED AT THE MEETING IN ACCORDANCE
WITH THE STOCKHOLDER'S DIRECTIONS ABOVE.  THE PROXY CONFERS DISCRETIONARY
AUTHORITY IN RESPECT TO MATTERS NOT KNOW OR DETERMINED AT THE TIME OF THE
MAILING OF THE NOTICE OF THE ANNUAL MEETING OF STOCKHOLDERS TO THE UNDERSIGNED.


                                             -----------------------------------
                                             Date

                                             -----------------------------------
                                             Signature of stockholder

                                             -----------------------------------
                                             Signature if held jointly

                                             Note: PLEASE MARK, DATE, SIGN AND
                                             RETURN THIS PROXY PROMPTLY USING
                                             THE ENCLOSED ENVELOPE.  If signing
                                             as attorney, executor,
                                             administrator, trustee or guardian,
                                             please give full title.  If a
                                             corporation or partnership, please
                                             sign in corporate or partnership
                                             name by an authorized person.




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