GENETICS INSTITUTE INC
S-8, 1994-05-23
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1


                               
                                                      
              As filed with the Securities and Exchange Commission
                                on May 23, 1994
                                                      Registration No. 33-

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                            GENETICS INSTITUTE, INC.
               -------------------------------------------------
               (Exact name of issuer as specified in its charter)

             DELAWARE                               04-2718435
  -------------------------------               ------------------
  (State or other jurisdiction of                (I.R.S. Employer
   incorporation or organization)               Identification No.)

87 CAMBRIDGEPARK DRIVE, CAMBRIDGE, MASSACHUSETTS     02140
- ------------------------------------------------   ----------
    (Address of Principal Executive Offices)       (Zip Code)

                       1991 EMPLOYEE STOCK PURCHASE PLAN
                       ---------------------------------
                            (Full title of the plan)

                              MARK G. BORDEN, ESQ.
                                 HALE AND DORR
                                60 STATE STREET
                          BOSTON, MASSACHUSETTS 02109
                    ---------------------------------------
                    (Name and address of agent for service)

                                 (617) 526-6000
         ------------------------------------------------------------
         (Telephone number, including area code, of agent for service)
<TABLE>
===============================================================================
                        CALCULATION OF REGISTRATION FEE

<CAPTION>
                               Proposed   Proposed
Title of                       maximum    maximum
securities         Amount      offering   aggregate     Amount of
to be              to be       price      offering      registration
registered         registered  per share  price         fee
- ----------         ----------  ---------  ---------     ------------
<S>                  <C>       <C>        <C>            <C>
Depositary Shares,   300,000   $43.125(1) $12,937,500(1)  $4,461.21     
each representing    shares
one share of
Common Stock,
$.01 par value,
subject to a call
option and
evidenced by a
depositary
receipt                                                              
- ---------------------------------------------------------------------
</TABLE>


                           
                   

<PAGE>   2


<TABLE>
<S>                       <C>      <C>            <C>          <C>
Common Stock,
$.01 par value            (2)      N/A            N/A          (3)   
- ---------------------------------------------------------------------
<FN>
(1)  Estimated solely for the purpose of calculating the
     registration fee, and based upon the average of the
     high and low prices of the Common Stock on the Nasdaq
     National Market on May 17, 1994 in accordance with
     Rules 457(c) and 457(h) of the Securities Act of 1933.

(2)  Such number of shares of Common Stock as are represented
     by the Depositary Shares registered hereby.

(3)  Because the Common Stock is issued for no consideration,
     no registration fee is required with respect thereto.
- ---------------------------------------------------------------------
</TABLE>

<PAGE>   3

  PART I.  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

       The information required by Part I is included in documents
  sent or given to participating employees of the 1991 Employee
  Stock Purchase Plan of Genetics Institute, Inc. (the "Registrant")
  pursuant to Rule 428(b)(1) of the Securities Act of 1933, as
  amended (the "Securities Act").

  PART II.  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

       Item 3.  Incorporation of Certain Documents by Reference.
                ------------------------------------------------

       The Registrant is subject to the informational and reporting
  requirements of Sections 13(a), 14, and 15(d) of the Securities
  Exchange Act of 1934 (as amended, the "Exchange Act"), and in
  accordance therewith files reports, proxy statements and other
  information with the Securities and Exchange Commission.  The
  following documents, which are filed with the Securities and
  Exchange Commission, are incorporated in this Prospectus by
  reference:

            (1)  The Registrant's latest annual report, as amended,
       filed pursuant to Section 13(a) or 15(d) of the Exchange Act,
       or the latest prospectus filed pursuant to Rule 424(b), or
       otherwise, under the Securities Act that contains audited
       financial statements for the Registrant's latest fiscal year
       for which such statements have been filed.

            (2)  All other reports filed pursuant to Section 13(a)
       or 15(d) of the Exchange Act since the end of the fiscal year
       covered by the annual report or the prospectus referred to in
       (1) above.

            (3)  The description of the common stock of the
       Registrant, par value $.01 per share ("Common Stock"),
       contained in a registration statement filed under the
       Exchange Act, including any amendment or report filed for the
       purpose of updating such description.

            (4)  The description of the depositary shares of the
       Registrant, each representing one share of Common Stock,
       subject to a call option and evidenced by a depositary
       receipt (the "Depositary Shares"), contained in a
       registration statement filed under the Exchange Act,
       including any amendment or report filed for the purpose of
       updating such description.

            (5)  The Registrant's definitive proxy statement or
       information statement, if any, filed pursuant to Section 14
       of the Exchange Act in connection with the latest annual


<PAGE>   4

       meeting of its stockholders, and any definitive proxy or
       information statements so filed in connection with any
       subsequent special meetings of its stockholders.

            (6)  Information as to stock options, including the
       amount outstanding, exercises, prices and expiration dates,
       included in the Registrant's definitive proxy statement,
       described in (4) above and which will be included in the
       future either in the Registrant's proxy statements, annual
       reports or appendices to the prospectus.

       All documents subsequently filed by the Registrant pursuant
  to Sections 13(a), 13(c), 14, and 15(d) of the Exchange Act prior
  to the filing of a post-effective amendment which indicates that
  all shares of Common Stock offered hereby have been sold or which
  deregisters all shares of Common Stock then remaining unsold,
  shall be deemed to be incorporated by reference herein and to be
  part hereof from the date of the filing of such documents.

       Item 4.  Description of Securities.
                -------------------------

            Not applicable.

       Item 5.  Interests of Named Experts and Counsel.
                --------------------------------------

            Not applicable.

       Item 6.  Indemnification
                ---------------

       Article TENTH of the Company's Restated Certificate of
  Incorporation provides that no director of the Company shall be
  liable for any breach of fiduciary duty, except to the extent that
  the Delaware General Corporation Law prohibits the elimination of
  limitation of liability of directors for breach of fiduciary duty.

       Article ELEVENTH of the Company's Restated Certificate of
  Incorporation provides that a director or officer of the Company
  (a) shall be indemnified by the Company against all costs,
  charges, expenses, (including attorneys' fees), judgments, fines
  and amounts paid in settlement actually and reasonably incurred in
  connection with any litigation or other legal proceeding (other
  than an action by or in the right of Genetics Institute) brought
  against such person by virtue of such person's position as a
  director or officer of the Company if such person acted in good
  faith and in a manner such person reasonably believed to be in, or
  not opposed to, the best interests of the Company, and, with
  respect to any criminal action or proceeding, has no reasonable
  cause to believe such person's conduct was unlawful and (b) shall
  be indemnified by the Company against all costs, charges and
  expenses (including attorneys' fees) actually and reasonably
  incurred in connection with any action by or in the right of the
  Company brought against such person by virtue or such person's


                                      -2-
<PAGE>   5

  position as a director or officer of the Company if such person
  acted in good faith and in a manner such person reasonably
  believed to be in, or not opposed to, the best interests of the
  Company, except that no indemnification shall be made with respect
  to any such matters as to which such person shall have been
  adjudged to be liable to the Company, unless a court determines
  that, despite such adjudication, in view of all of the
  circumstances, such person is entitled to indemnification of such
  expenses.  Notwithstanding the foregoing, to the extent that a
  director or officer has been successful, on the merits or
  otherwise, including without limitation, the dismissal of an
  action without prejudice or the settlement of an action without
  admission of liability, such person is required to be indemnified
  by the Company against all costs, charges and expenses (including
  attorneys' fees) actually and reasonably incurred in connection
  therewith.  Expenses shall be advanced to a director or officer at
  such person's request, provided that such person undertakes to
  repay the amount advanced if it is ultimately determined that such
  person is not entitled to indemnification or such expenses.

       Indemnification is required to be made unless a majority of a
  quorum of the disinterested directors of the Board of Directors,
  or if no such quorum is met, independent legal counsel determines
  that the applicable standard of conduct required for
  indemnification has not been met.  In the event of a determination
  by a majority of a quorum of the disinterested directors of the
  Board of Directors or, if no such quorum is met, independent legal
  counsel that the director or officer did not meet the applicable
  standard of conduct required for indemnification, or if the
  Company fails to make a determination within 60 days after such
  payment is claimed by such person, such person is permitted to
  petition the court to make an independent determination as to
  whether such person is entitled to indemnification.  As a
  condition precedent to the right of indemnification, the director
  or officer must give the Company notice of the action for which
  indemnity is sought and the Company has the right to participate
  in such action or assume the defense thereof.

       Article ELEVENTH of the Company's Restated Certificate of
  Incorporation further provides that the indemnification set forth
  therein is not exclusive, and provides that in the event that the
  Delaware General Corporation Law is amended to expand the
  indemnification permitted to directors or officers, the Company
  must indemnify those persons to the fullest extent permitted by
  such laws as so amended.

       Substantially similar indemnification provisions are
  contained in the By-laws of the Company.

       Item 7.  Exemption from Registration Claimed
                -----------------------------------

            Not applicable.


                                      -3-
<PAGE>   6

       Item 8.  Exhibits.
                --------

            The Exhibit Index immediately preceding the exhibits is
  incorporated herein by reference.

       Item 9.  Undertakings.
                ------------

            1.   The Registrant hereby undertakes:

            (a)  To file, during any period in which offers or sales
       are being made, a post-effective amendment to this
       registration statement:

            (i)  To include any prospectus required by Section
       10(a)(3) of the Securities Act;

           (ii)  To reflect in the prospectus any facts or events
       arising after the effective date of the registration
       statement (or the most recent post-effective amendment
       thereof) which, individually or in the aggregate, represent a
       fundamental change in the information set forth in the
       registration statement; and

          (iii)  To include any material information with respect to
       the plan of distribution not previously disclosed in the
       registration statement or any material change to such
       information in the registration statement;

       PROVIDED, HOWEVER that paragraphs (i) and (ii) do not apply
       if the registration statement is on Form S-3 or Form S-8, and
       the information required to be included in a post-effective
       amendment by those paragraphs is contained in periodic
       reports filed by the Company pursuant to Section 13 or
       Section 15(d) of the Exchange Act that are incorporated by
       reference in the registration statement.

            (b)  That, for the purpose of determining any liability
       under the Securities Act, each such post-effective amendment
       shall be deemed to be a new registration statement relating
       to the securities offered therein, and the offering of such
       securities at that time shall be deemed to be the initial
       bona fide offering thereof.

            (c)  To remove from registration by means of a
       post-effective amendment any of the securities being
       registered which remain unsold at the termination of the
       offering.

       2.   The Registrant hereby undertakes that, for purposes of
  determining any liability under the Securities Act, each filing of
  the Company's annual report pursuant to Section 13(a) or
  Section 15(d) of the Exchange Act (and, where applicable, each


                                      -4-

<PAGE>   7

  filing of an employee benefit plan's annual report pursuant to
  Section 15(d) of the Exchange Act) that is incorporated by
  reference in the registration statement shall be deemed to be a
  new registration statement relating to the securities offered
  therein, and the offering of such securities at that time shall be
  deemed to be in the initial bona fide offering thereof.

       3.   Insofar as indemnification for liabilities arising under
  the Securities Act may be permitted to directors, officers and
  controlling persons of the Registrant pursuant to the foregoing
  provisions, or otherwise, the Registrant has been advised that in
  the opinion of the Securities and Exchange Commission such
  indemnification is against public policy as expressed in the
  Securities Act and is, therefore, unenforceable.  In the event
  that a claim for indemnification against such liabilities (other
  than the payment by the Registrant of expenses incurred or paid by
  a director, officer or controlling person of the Registrant in the
  successful defense of any action, suit or proceeding) is asserted
  by such director, officer or controlling person in connection with
  the securities being registered, the Registrant will, unless in
  the opinion of its counsel the matter has been settled by
  controlling precedent, submit to a court of appropriate
  jurisdiction the question whether such indemnification by it is
  against public policy as expressed in the Securities Act and will
  be governed by the final adjudication of such issue.



                                      -5-
<PAGE>   8


                             SIGNATURES

       Pursuant to the requirements of the Securities Act, the
  registrant certifies that it has reasonable grounds to believe
  that it meets all of the requirements for filing on Form S-8 and
  has duly caused this Registration Statement to be signed on its
  behalf by the undersigned, thereunto duly authorized, in the City
  of Boston, Commonwealth of Massachusetts on the 23rd day of May,
  1994.


                                     GENETICS INSTITUTE, INC.


                                         GABRIEL SCHMERGEL
                                     By: __________________________
                                         Gabriel Schmergel
                                         President and
                                         Chief Executive Officer






                          POWER OF ATTORNEY

       We, the undersigned officers and directors of Genetics
  Institute, Inc. hereby severally constitute Gabriel Schmergel,
  Garen G. Bohlin and Lawrence V. Stein, and each of them singly,
  our true and lawful attorneys with full power to them, and each of
  them singly, to sign for us and in our names in the capacities
  indicated below, the Registration Statement on Form S-8 filed
  herewith and any and all subsequent amendments to said
  Registration Statement, and generally to do all such things in our
  names and behalf in our capacities as officers and directors to
  enable Genetics Institute, Inc. to comply with all requirements of
  the Securities and Exchange Commission, hereby ratifying and
  confirming our signatures as they may be signed by said attorneys,
  or any of them, to said Registration Statement and any and all
  amendments thereto.





                                      -6-


<PAGE>   9

       Pursuant to the requirements of the Securities Act, this
  Registration Statement has been signed below by the following
  persons in the capacities and on the dates indicated.

       Signature                     Title
       ---------                     -----


     GABRIEL SCHMERGEL      President, Chief           )
- -------------------------   Executive Officer and      )
     Gabriel Schmergel      Director (Principal        )
                            Executive Office)          )
                                                       )
                                                       )
      GAREN G. BOHLIN       Executive Vice President   )
- -------------------------   (Principal Financial and   )
      Garen G. Bohlin       Accounting Officer)        )
                                                       )
                                                       )
      BENNO C. SCHMIDT      Chairman of the Board and  )
- -------------------------   Director                   )
      Benno C. Schmidt                                 )
                                                       )
                                                       )
                                                       )
- -------------------------   Director                   )
      James G. Andress                                 )  May 23, 1994
                                                       )
                                                       )
      ANTHONY B. EVNIN      Director                   )
- -------------------------                              )
      Anthony B. Evnin                                 )
                                                       )
                                                       )
        FRED HASSAN         Director                   )
- -------------------------                              )
        Fred Hassan                                    )
                                                       )
                                                       )
                                                       )
- -------------------------   Director                   )
     Thomas P. Maniatis                                )
                                                       )
                                                       )
       ROBERT I. LEVY       Director                   )
- -------------------------                              )
       Robert I. Levy                                  )
                                                       )


                                   -7-

<PAGE>   10

<TABLE>
                             EXHIBIT INDEX
                             -------------

<CAPTION>
Exhibit
Number       Description                                         Page
- -------      -----------                                         ----
<S>       <C>                                                    <C>
3.(i)     Restated Certificate of Incorporation (1)              --

3.(ii)    Restated By-laws of the Registrant (2)                 --

  5.1     Opinion of Hale and Dorr.

 23.1     Consent of Hale and Dorr (included in Exhibit 5.1).    --

 23.2     Consent of Arthur Andersen.                            --

 23.3     Consent of Coopers & Lybrand.                          --

 24.1     Power of Attorney (included in the signature
          pages of this Registration Statement).                 --




<FN>
  ______________________
  (1)  Filed as an Exhibit to the Registrant's Annual Report on
       Form 10-K for the year ended November 30, 1990 and
       incorporated herein by reference.

  (2)  Filed as an Exhibit to the Registrant's Registration
       Statement on Form S-1 (File No. 33-14013) on May 5, 1987 and
       incorporated herein by reference.
</TABLE>

                                      -8-

<PAGE>   1


                                                        EXHIBIT 5.1
                                                        -----------




                                  May 23, 1994



  Genetics Institute, Inc.
  87 CambridgePark Drive
  Cambridge, MA  02140

       Re:  1991 Employee Stock Purchase Plan
            ---------------------------------

  Ladies and Gentlemen:

       We have assisted in the preparation of a Registration
  Statement on Form S-8 (the "Registration Statement") to be filed
  with the Securities and Exchange Commission relating to 300,000
  Depositary Shares, each representing one share of Common Stock,
  $.01 par value per share, subject to a call option and evidenced
  by a depositary receipt (the "Depositary Shares"), of Genetics
  Institute, Inc., a Delaware corporation (the "Company"), issuable
  under the Company's 1991 Employee Stock Purchase Plan (the
  "Plan").

       We have examined the Restated Certificate of Incorporation of
  the Company, the Restated By-laws of the Company, and originals,
  or copies certified to our satisfaction, of all pertinent records
  of the meetings of the directors and stockholders of the Company,
  the Registration Statement and such other documents relating to
  the Company as we have deemed material for the purposes of this
  opinion.

       In examination of the foregoing documents, we have assumed
  the genuineness of all signatures and the authenticity of all
  documents submitted to us as originals, the conformity to original
  documents of all documents submitted to us as certified or
  photostatic copies, and the authenticity of the originals of such
  latter documents.

<PAGE>   2

  Genetics Institute, Inc.
  May 23, 1994
  Page 2




       Based on the foregoing, we are of the opinion that the
  Company has duly authorized for issuance the shares of its Common
  Stock covered by the Registration Statement to be issued under the
  Plan, as described in the Registration Statement, and such shares,
  when issued in accordance with the terms of the Plan, will be
  legally issued, fully paid and nonassessable.

       We hereby consent to the filing of this opinion with the
  Securities and Exchange Commission in connection with the
  Registration Statement.

                                Very truly yours,



                                HALE AND DORR



<PAGE>   1


                                                                EXHIBIT 23.2
                                                                ------------







                   CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS



As independent public accountants, we hereby consent to the incorporation by
reference in this registration statement of our report dated December 22, 1993
incorporated by reference in Genetics Institute, Inc.'s Form 10-K for the year
ended November 30, 1993 and to all references to our Firm included in this
registration statement.


                                             ARTHUR ANDERSEN & CO.



Boston, Massachusetts
May 20, 1994




<PAGE>   1


                                                             EXHIBIT 23.3
                                                             ------------




                   CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


We consent to the incorporation by reference in the registration statement of
Genetics Institute, Inc. on Form S-8 of our reports dated December 29, 1992, on
our audits of the consolidated financial statements and financial statement
schedules of Genetics Institute, Inc. and Subsidiaries as of November 30, 1992,
and for the years ended November 30, 1992 and 1991, which reports are
incorporated by reference in Genetics Institute, Inc. 1993 Annual Report on
Form 10-K.


                                                COOPERS & LYBRAND


Boston, Massachusetts
May 20, 1994




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