GENETICS INSTITUTE INC
S-8, 1995-05-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
               As filed with the Securities and Exchange Commission
                               on May 30, 1995
                                                  Registration No. 33-     

===============================================================================
                         SECURITIES AND EXCHANGE COMMISSION
                               WASHINGTON, D.C. 20549

                                      FORM S-8

                            REGISTRATION STATEMENT UNDER
                             THE SECURITIES ACT OF 1933

                               GENETICS INSTITUTE, INC.                   
                 (Exact name of issuer as specified in its charter)

                    DELAWARE                               04-2718435     
         (State or other jurisdiction of                (I.R.S. Employer
          incorporation or organization)               Identification No.)

          87 CAMBRIDGEPARK DRIVE, CAMBRIDGE, MASSACHUSETTS   02140
              (Address of Principal Executive Offices)     (Zip Code)

                                 1991 STOCK OPTION PLAN
                                (Full title of the plan)

                                  MARK G. BORDEN, ESQ.
                                      HALE AND DORR
                                     60 STATE STREET
                               BOSTON, MASSACHUSETTS  02109  
                         (Name and address of agent for service)

                                     (617) 526-6000
              (Telephone number, including area code, of agent for service)
                                                                            
<TABLE>
                            CALCULATION OF REGISTRATION FEE
================================================================================
<CAPTION>
                                      Proposed   Proposed
       Title of                       maximum    maximum
       securities         Amount      offering   aggregate       Amount of
       to be              to be       price      offering        registration
       registered         registered  per share  price           fee          
       ----------         ----------  ---------  ---------       ------------
       <S>                <C>         <C>        <C>             <C>
       Depositary Shares, 1,300,000   $36.25(1)  $47,125,000(1)  $16,250
       each representing    shares
       one share of 
       Common Stock,
       $.01 par value,
       subject to a call
       option and 
       evidenced by a 
       depositary
       receipt
- --------------------------------------------------------------------------------
</TABLE>

                          
<PAGE>   2

<TABLE>
       <S>                       <C>      <C>            <C>          <C>
       Common Stock,
       $.01 par value            (2)      N/A            N/A          (3)
- --------------------------------------------------------------------------------
<FN>
       (1)  Estimated solely for the purpose of calculating the
            registration fee, and based upon the average of the
            high and low prices of the Common Stock on the Nasdaq
            National Market on May 25, 1995 in accordance with
            Rules 457(c) and 457(h) of the Securities Act of 1933.

       (2)  Such number of shares of Common Stock as are represented 
            by the Depositary Shares registered hereby.

       (3)  Because the Common Stock is issued for no consideration, 
            no registration fee is required with respect thereto.

================================================================================
</TABLE>







                                         -2-
<PAGE>   3

                      Statement of Incorporation by Reference
                      ---------------------------------------

              This Registration Statement on Form S-8 incorporates by
         reference the contents of the Registration Statements on Form S-8,
         File Nos. 33-43651, filed by the Registrant on November 5, 1991,
         and 33-63052, filed on May 20, 1993, relating to the Registrant's
         1991 Stock Option Plan.  















                                         -3-

<PAGE>   4

                                     SIGNATURES

              Pursuant to the requirements of the Securities Act, the
         registrant certifies that it has reasonable grounds to believe
         that it meets all of the requirements for filing on Form S-8 and
         has duly caused this Registration Statement to be signed on its
         behalf by the undersigned, thereunto duly authorized, in the City
         of Boston, Commonwealth of Massachusetts on the 25th day of May,
         1995.


                                            GENETICS INSTITUTE, INC.



                                            By: /s/ Gabriel Schmergel     
                                                ----------------------
                                                Gabriel Schmergel
                                                President and Chief 
                                                  Executive Officer




                                  POWER OF ATTORNEY

              We, the undersigned officers and directors of Genetics
         Institute, Inc. hereby severally constitute Gabriel Schmergel,
         Garen G. Bohlin and Mark G. Borden, and each of them singly, our
         true and lawful attorneys with full power to them, and each of
         them singly, to sign for us and in our names in the capacities
         indicated below, the Registration Statement on Form S-8 filed
         herewith and any and all subsequent amendments to said
         Registration Statement, and generally to do all such things in our
         names and behalf in our capacities as officers and directors to
         enable Genetics Institute, Inc. to comply with all requirements of
         the Securities and Exchange Commission, hereby ratifying and
         confirming our signatures as they may be signed by said attorneys,
         or any of them, to said Registration Statement and any and all
         amendments thereto.

              WITNESS our hands and common seal on the date set forth
         below.

                                         -4-
<PAGE>   5

<TABLE>
           Pursuant to the requirements of the Securities Act of 1933, this
      Registration Statement has been signed below by the following persons
      in the capacities and on the dates indicated.  

<CAPTION>

              Signature              Title                        Date
              ---------              -----                        ----

         <S>                      <C>                      <C>
         /s/ Gabriel Schmergel    President, Chief         )
         ----------------------   Executive Officer and    )
         Gabriel Schmergel        Director (Principal      )
                                  Executive Officer)       )
                                                           )
                                                           )
                                                           )
         /s/ Garen G. Bohlin      Executive Vice President )
         ----------------------   (Principal Financial     )
         Garen G. Bohlin          Officer and Principal    )
                                  Accounting Officer)      )
                                                           )
                                                           )
         /s/ James G. Andress     Director                 )
         ----------------------                            )
         James G. Andress                                  )
                                                           )
                                                           )
         /s/ J. Richard Crout     Director                 )
         ----------------------                            )
         J. Richard Crout                                  )
                                                           )
                                                           )
         /s/ Anthony B. Evnin     Director                 )  May 25, 1995
         ----------------------                            )
         Anthony B. Evnin                                  )
                                                           )
                                                           )
         /s/ Fred Hassan          Director                 )
         ----------------------                            )
         Fred Hassan                                       )
                                                           )
                                                           )
         /s/ Robert I. Levy       Director                 )
         ----------------------                            )
         Robert I. Levy                                    )
                                                           )
                                                           )
         /s/ Thomas P. Maniatis   Director                 )
         ----------------------                            )
         Thomas P. Maniatis                                )
                                                           )
                                                           )
         /s/ Benno C. Schmidt     Director                 )
         ----------------------                            )
         Benno C. Schmidt                                  )

</TABLE>


                                         -5-
<PAGE>   6


<TABLE>
                                     EXHIBIT INDEX
                                     -------------
<CAPTION>

    Exhibit
    Number       Description                                         Page
    -------      -----------                                         ----
      <S>        <C>                                                  <C>
       4.1       Restated Certificate of Incorporation. (1)           --

       4.2       Restated By-laws of the Registrant. (2)              --

       4.3       Depositary Agreement among Genetics Institute,
                 Inc., American Home Products Corporation,
                 AHP Biotech Holdings, Inc. and The First
                 National Bank of Boston, as Depositary.(1)           --

       5.1       Opinion of Hale and Dorr.                              

      23.1       Consent of Hale and Dorr (included in Exhibit 5.1).  --

      23.2       Consent of Arthur Andersen LLP.

      23.3       Consent of Coopers & Lybrand L.L.P.                    

      24.1       Power of Attorney (included in the signature 
                 pages of this Registration Statement).               --









<FN>

         ______________________
         (1)  Filed as an exhibit to the Company's Annual Report on
              Form 10-K for the year ended November 30, 1991 (File No. 0-
              14587) on February 28, 1992 and incorporated herein by
              reference.

         (2)  Filed as an exhibit to the Company's Quarterly Report on
              Form 10-Q/A for the quarter ended March 31, 1995 
              (File No. 0-14587) on May 26, 1995 and incorporated herein by
              reference.

</TABLE>


                                         -5-

<PAGE>   1


                                                                  EXHIBIT 5.1

                                 Hale & Dorr
                              Counsellors at Law
                                      
                 60 State Street, Boston, Massachusetts 02109
                      617-526-6000     FAX 617-526-5000

                                                                  May 25, 1995
                              
         Genetics Institute, Inc.
         87 CambridgePark Drive
         Cambridge, MA  02140

              Re:  1991 Stock Option Plan
                   ----------------------

         Ladies and Gentlemen:

              We have assisted in the preparation of a Registration
         Statement on Form S-8 (the "Registration Statement") to be filed
         with the Securities and Exchange Commission relating to 1,300,000
         Depositary Shares, each representing one share of Common Stock,
         $.01 par value per share, subject to a call option and evidenced
         by a depositary receipt (the "Depositary Shares"), of Genetics
         Institute, Inc., a Delaware corporation (the "Company"), issuable
         under the Company's 1991 Stock Option Plan (the "Plan").  Each
         Depositary Share represents one share of Common Stock subject to a
         call option held by AHP Biotech Holdings, Inc. ("Holdings") and
         evidenced by a depositary receipt.

              We have examined the Restated Certificate of Incorporation of
         the Company, the Restated By-laws of the Company, and originals,
         or copies certified to our satisfaction, of all pertinent records
         of the meetings of the directors and stockholders of the Company,
         the Depositary Agreement dated as of January 16, 1992 among the
         Company, American Home Products Corporation, Holdings and The
         First National Bank of Boston, the Registration Statement and such
         other documents relating to the Company as we have deemed material
         for the purposes of this opinion.

              In examination of the foregoing documents, we have assumed
         the genuineness of all signatures and the authenticity of all
         documents submitted to us as originals, the conformity to original
         documents of all documents submitted to us as certified or
         photostatic copies, and the authenticity of the originals of such
         latter documents.

                                         -1-
<PAGE>   2

         Genetics Institute, Inc.
         May 25, 1995
         Page 2




              Based on the foregoing, we are of the opinion that the
         Depositary Shares and the corresponding shares of Common Stock
         covered by the Registration Statement to be issued under the Plan,
         as described in the Registration Statement, have been duly
         authorized for issuance by the Company and, when issued in
         accordance with the terms of the Plan, will be legally issued,
         fully paid and nonassessable.

              We hereby consent to the filing of this opinion with the
         Securities and Exchange Commission in connection with the
         Registration Statement.

                                       Very truly yours,


                                       /s/ Hale and Dorr
                                       HALE AND DORR














                                         -2-


<PAGE>   1
                                                               Exhibit 23.2
                                                               ------------

                      CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

         As independent public accountants, we hereby consent to the
         incorporation by reference in this registration statement of our
         report dated January 18, 1995 included in Genetics Institute,
         Inc.'s Form 10-K for the year ended December 31, 1994 and to all
         references to our Firm included in this registration statement




         Boston, Massachusetts                   ARTHUR ANDERSEN LLP
         May 25, 1995
















                                         -1-

<PAGE>   1

                                                               EXHIBIT 23.3
                                                               ------------




                      CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

We consent to the incorporation by reference in the Registration Statement on
Form S-8 of Genetics Institute, Inc. of our reports dated December 29, 1992, on
our audits of the consolidated financial statements and financial statement
schedules of Genetics Institute, Inc. and Subsidiaries as of November 30, 1992
and for the year ended November 30, 1992 which reports are incorporated by
reference and included in the Genetics Institute, Inc. 1993 Annual Report on
Form 10-K.


                                      COOPERS & LYBRAND L.L.P.

Boston, Massachusetts
May 25, 1995


















                                         -1-


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