GENETICS INSTITUTE INC
SC 13D/A, 1996-06-06
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                               UNITED STATES
                    SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C. 20549

                              SCHEDULE 13D/A

                 Under the Securities Exchange Act of 1934

                             (AMENDMENT NO. 5)

                        GENETICS INSTITUTE, INC.
                         -----------------------
                            (Name of Issuer)
                              Common Stock
                              ------------
                     (Title of Class of Securities)
                                    
                               371855 10 7
                               -----------
                             (CUSIP Number)
                                    
                       LOUIS L. HOYNES, JR., ESQ.
                Senior Vice President and General Counsel
                   American Home Products Corporation
                  5 Giralda Farms, Madison, N.J. 07940
                             (201) 660-5000
                      ----------------------------
(Name, Address and Telephone Number of Person Authorized to Receive Notices
                           and Communications)

                               June 4, 1996
                       ---------------------------
          (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(b)(3) or (4), check the following
box [  ].

Check the following box if a fee is being paid with the statement [  ].  (A
fee is not required only if the reporting person: (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class
of securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are
to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the
Securities Exchange Act of 1934 but shall be subject to all other provisions
of the (however, see the Notes).
<PAGE>
CUSIP No. 371855 10 7

1.   NAME OF REPORTING PERSON
     S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     AHP Biotech Holdings, Inc.
     Tax I.D. 13-3641807

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
     (a) [ ]
     (b) [X]

3.   SEC USE ONLY

4.   SOURCE OF FUNDS*

     WC

5.   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) or 2(e)

     [ ]

6.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

7.   SOLE VOTING POWER

     29,531,619.15

8.   SHARED VOTING POWER

     29,531,619.15

9.   SOLE DISPOSITIVE POWER

     29,531,619.15

10.  SHARED DISPOSITIVE POWER

     

11.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 

     29,531,619.15

12.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* 
     [ ]

13.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     100%

14.  TYPE OF REPORTING PERSON*

     CO
                   *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

     The statement on Schedule 13D dated January 24, 1992, for the event
which occurred on January 16, 1992, which was amended by Amendment No. 1,
dated June 8, 1993, Amendment No. 2, dated July 29, 1993, Amendment No. 3,
dated February 14, 1994, and Amendment No. 4, dated April 9, 1996 is hereby
further amended in connection with the purchase by the Reporting Person (as
defined herein), in accordance with and as required by the provisions of the
Merger Agreement (as defined herein), of shares of Common Stock of Genetics
Institute, Inc. in connection with the exercise of the balance of the
outstanding warrants of Genetics Institute, Inc. which would otherwise have
expired on May 31, 1996.

     Item 3 is hereby amended to add the following language to the last
paragraph of Item 3:

     In addition, on April 22, 1996, April 29, 1996, May 6, 1996, May
     13, 1996, May 20, 1996 and June 4, 1996 the Reporting Person
     purchased 160, 24,738, 6,825.2, 40,352, 6,025.6 and 747,928.4
     Shares, respectively, from the Company.  The aggregate
     consideration of $8,000, $1,236,900, $341,260, $2,017,600,
     $301,280 and $37,396,420, respectively, paid by the Reporting
     Person was financed from the working capital of the Reporting
     Person.

     Item 5(a) is hereby amended by deleting the first paragraph of the Item
in its entirety and replacing it with the following:

     (a)  Following the purchase of the Shares as described in Item
     5(c) below, the Reporting Person is the beneficial owner of
     29,531,619.15 Shares, consisting of (i) 5,867,111.2 Merger Shares;
     (ii) 9,466,709 Additional Shares; (iii) 947,000 Shares underlying
     947,000 Depositary Shares held by the Reporting Person; (iv)
     11,747,728.72 Shares subject to the Call Option; (v) 649,608.57
     Shares purchased in July 1993 upon conversion of the Preferred
     Stock; (vi) 2,448.57 Shares purchased other than in July 1993 upon
     conversion of the Preferred Stock; (vii) 14,863.89 Shares
     purchased pursuant to the Standby Agreement; (viii) an aggregate
     of 836,149.2 Shares purchased pursuant to the Merger Agreement
     upon the exercise of warrants to purchase Shares.  Based on
     29,531,619.15 Shares deemed to be outstanding pursuant to Rule
     13d-3 of the Act, the Shares beneficially owned by the Reporting
     Person constitute approximately 100% of the outstanding Shares.

     Item 5(c) is hereby amended to add the following language at the end of
Item 5(c):

     On April 22, 1996, April 29, 1996, May 6, 1996, May 13, 1996, May
     20, 1996 and June 4, 1996 upon exercise of additional outstanding
     warrants the Reporting Person purchased 160, 24,738, 6,825.2,
     40,352, 6,025.6 and 747,928.4 Shares, respectively, from the
     Company pursuant to its obligations under the Merger Agreement. 
     The information set forth in Item 3 of this Schedule 13D is hereby
     incorporated herein to this Item 5(c) by reference.

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

     Dated:    June 5, 1996

                    AHP BIOTECH HOLDINGS, INC.

                    By:  /s/ Robert G. Blount
                         Robert G. Blount
                         Vice President


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