GENZYME CORP
8-K, 1996-07-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                                    FORM 8-K
                                 CURRENT REPORT


     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934


                Date of Report (Date of earliest event reported)
                                  JULY 1, 1996


                               GENZYME CORPORATION
             (Exact name of registrant as specified in its charter)


 
        MASSACHUSETTS                  0-14680                  06-1047163
(State or other jurisdiction       (Commission File           (IRS Employer 
     of incorporation)                 Number)              Identification No.)



               ONE KENDALL SQUARE, CAMBRIDGE, MASSACHUSETTS 02139
              (Address or principal executive offices and zip code)


               Registrant's telephone number, including area code
                                 (617) 252-7500




<PAGE>   2


ITEM 2. ACQUISITION OR DISPOSITION OF ASSETS.

On July 1, 1996, Genzyme Corporation ("Genzyme"), a Massachusetts corporation
completed the acquisition of Deknatel Snowden Pencer, Inc. ("DSP"), a privately
held surgical products company, for approximately $250.0 million. The purchase
price consisted of cash of approximately $190.0 million. Genzyme also assumed
and subsequently repaid debt of DSP of approximately $56.5 million, and Genzyme
paid acquisition costs of approximately $3.5 million. Funds for the acquisition,
the repayment of the debt and the payment of the acquisition costs were provided
by borrowings of $200.0 million under a revolving credit facility from Fleet
National Bank, due September 1, 1997, with interest payable at LIBOR plus 5/8%
(6.16% at July 1, 1996) and approximately $50.0 million was provided from
Genzyme General Division cash balances.

The acquisition was accomplished by a merger of DSP Acquisition Corp.
("Acquisition"), a wholly-owned subsidiary of Genzyme, with and into DSP,
resulting in DSP being the surviving corporation as a wholly-owned subsidiary of
Genzyme (the "Merger"). As a result of the Merger, each outstanding share of the
capital stock of DSP was converted into the right to receive $379.01 in cash
(the "Merger Consideration"), and certain outstanding options to purchase the
capital stock of DSP were converted into the right to receive the Merger
Consideration multiplied by the number of shares for which such option was
exercisable, less the exercise price of such option.

The nature and amount of the consideration paid in the Merger was determined by
negotiation between Genzyme and DSP and its principal stockholder, KDK
Acquisition Company, L.P. Such negotiation followed a bidding process in which
DSP, through its investment bankers retained for such purpose, solicited
proposals for the acquisition of the company. There was no material relationship
between DSP or its shareholders and Genzyme or any of its affiliates, directors
or officers, or any associate of a Genzyme director or officer.

DSP designs, manufactures and markets cardiovascular devices, precision
instruments and specialty surgical products. Its 70-person sales force calls
directly on cardiovascular, general and gynecological surgeons throughout the
U.S. and Europe and has a strong presence in the operating rooms of major
hospitals. Genzyme will retain DSP personnel and facilities and continue to
pursue DSP's growth strategy.

Genzyme plans to use DSP's sales force to accelerate the introduction of its
Seprafilm[Trademark] bioresorbable membrane to the U.S. surgical market once it 
is approved by the U.S. Food and Drug Administration.



                                       2
<PAGE>   3

ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS.

      Genzyme hereby incorporates by reference into this report, the following
      financial statements included on pages F-1 through F-29 in Genzyme's
      Registration Statement on Form S-3 (File No. 333-05979), dated June 24,
      1996:

           (a) Historical financial statements of DSP as of September 30, 1995
                    and 1994 and March 24, 1996 (unaudited) and for the years
                    ended September 30, 1994 and 1995 and the six months ended
                    March 26, 1995 and March 24, 1996 (unaudited).

           (b) Pro forma financial statements of Genzyme Corporation and
                    Genzyme General Division as of March 31, 1996 and for the
                    three months ended March 31, 1996 and for the year ended
                    December 31, 1995 presented assuming that the acquisition of
                    DSP occurred as of January 1, 1995.



           (c) Exhibits.

            Exhibit
              No.                        Description
              ---                        -----------


            Exhibit 2.1       Merger agreement dated as of May 24, 1996, among
                              Genzyme Corporation, DSP Acquisition Corporation
                              and Deknatel Snowden Pencer, Inc. Filed as Exhibit
                              2.1 to Genzyme's Registration Statement on Form
                              S-3 (File No. 333-05979), dated dated June 24,
                              1996 incorporated herein by reference. Pursuant to
                              Item 602(b)(2) of Regulation S-K, the schedules to
                              the Agreement and Plan of Merger are omitted. A
                              list of such schedules appears in the table of
                              contents to the Merger Agreement. The Registrant
                              hereby undertakes to furnish supplementary a copy
                              of any omitted schedule to the Commission upon
                              request.

            Exhibit 4.1       Credit Agreement dated as of June 28, 1996 between
                              Genzyme and Fleet National Bank. Filed herewith.




                                       3
<PAGE>   4


            (c) Exhibits (continued).

            Exhibit
              No.                        Description
              ---                        -----------


            Exhibit 4.2       Revolving Credit Note in the principal amount of
                              $215.0 million dated June 28, 1996 payable to 
                              Fleet National Bank. Filed herewith.

            Exhibit 23.2      Consent of Arthur Andersen LLP, independent
                              accountants to DSP. Filed herewith.

            Exhibit 99        Pages F-1 through F-29 in Genzyme's Registration
                              Statement on Form S-3 (File No. 333-05979), dated
                              June 24, 1996. Incorporated herein by reference.





                                       4
<PAGE>   5



                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                         GENZYME CORPORATION
                                              (Registrant)
          

Date: July 15, 1996                      By: /s/ David J. McLachlan
                                             ------------------------------

                                             (signature)
                                             David J. McLachlan
                                             Senior Vice President, Finance










                                       5
<PAGE>   6

                                  EXHIBIT INDEX


Exhibit                                                              Sequential
  No.                        Description                               Page No.
  ---                        -----------                               --------


Exhibit 2.1       Merger agreement dated as of May 24, 1996,
                  among Genzyme Corporation, DSP Acquisition
                  Corporation and Deknatel Snowden Pencer, Inc.
                  Filed as Exhibit 2.1 to Genzyme's Registration
                  Statement on Form S-3 (File No. 333-05979),
                  dated June 24, 1996 incorporated herein by
                  reference.  Pursuant to Item 602(b)(2) of
                  Regulation S-K, the schedules to the Agreement
                  and Plan of Merger are omitted.  A list of such
                  schedules appears in the table of contents to the
                  Merger Agreement.  The Registrant hereby
                  undertakes to furnish supplementary a copy of any
                  omitted schedule to the Commission upon request.

Exhibit 4.1       Credit Agreement dated as of June 28, 1996 between 
                  Genzyme and Fleet National Bank. Filed herewith.

Exhibit 4.2       Revolving Credit Note in the principal amount of 
                  $215.0 million dated June 28 1996 payable to Fleet 
                  National Bank. Filed herewith.

Exhibit 23.2      Consent of Arthur Andersen LLP, independent 
                  accountants to DSP.  Filed herewith.

Exhibit 99        Pages F-1 through F-29 in Genzyme's Registration 
                  Statement on Form S-3 (File No. 333-05979), dated 
                  June 24, 1996. Incorporated herein by reference.








                                       6

<PAGE>   1
                                
                                                                    EXHIBIT 4.1



















                               FLEET NATIONAL BANK

                                       AND

                               GENZYME CORPORATION


                                CREDIT AGREEMENT

                                  JUNE 28, 1996





<PAGE>   2


                                TABLE OF CONTENTS
                                -----------------


1. BACKGROUND AND DEFINED TERMS..............................................1

  1.1. Original Agreement....................................................1
  1.2. $15,000,000 Revolving Line of Credit..................................1
  1.3 $215,000,000 Line of Credit............................................1
  1.4 Defined Terms..........................................................1

2. REVOLVING LINE OF CREDIT..................................................1

  2.1 Revolving Credit Commitment............................................1
  2.2. Procedure for Revolving Credit Borrowings.............................1
  2.3 Interest on Revolving Credit Loans.....................................2
    2.3.1 LIBOR Advances.....................................................2
    2.3.2 Cost of Funds Advances.............................................2
  2.4 Payment of Interest....................................................3
  2.5 Default Rate...........................................................3
  2.6 Revolving Credit Note..................................................3
  2.7 Calculation of Interest................................................3
  2.8 Interest Limitation....................................................3
  2.9 Fees...................................................................3
    2.9.1 Structuring Fee....................................................3
    2.9.2 Undrawn Commitment Fee.............................................4
    2.9.3 Late Payment Charge................................................4
  2.10 Payments..............................................................4
  2.11 Reduction in Revolving Credit Commitment..............................4
  2.12 Prepayment............................................................5
    2.12.1 Mandatory Prepayment..............................................5
    2.12.2 Voluntary Prepayment..............................................5
  2.13 Make Whole Provision..................................................5
  2.14 Increased Costs.......................................................5
  2.15 Illegality............................................................6
  2.16 Additional Advance Conditions.........................................6
    2.16.1 Availability......................................................6
    2.16.2 Payments Net of Taxes.............................................6
    2.16.3 Successor LIBOR Interest Period Not Selected......................7
    2.16.4 Successor Cost of Funds Maturity Date Not Selected................7

3. REPRESENTATIONS AND WARRANTIES............................................7

  3.1 Financial Information..................................................7
  3.2 No Violations..........................................................7
  3.3 No Litigation..........................................................7
  3.4 Use of Proceeds........................................................8
  3.5 Organization...........................................................8
  3.6 Due Authority..........................................................8
  3.7 Authorization..........................................................8
  3.8 Valid and Binding......................................................8
  3.9 IRC and ERISA..........................................................8
  3.10 No Default............................................................9
  3.11 Taxes.................................................................9




                                     - i -
<PAGE>   3


  3.12 Intellectual Property Rights..........................................9
  3.13 Consents; No Burdensome Agreements...................................10
  3.14 Compliance with Laws Including Environmental and Safety Matters......10
  3.15 No Liens.............................................................10
  3.16 Regulation U, Etc. ..................................................10
  3.17 Investment Company Act, Etc. ........................................10
  3.18 Background Information and Certificates..............................11
  3.19 Continuous Nature of Representations and Warranties..................11
4. COVENANTS................................................................11

  4.1 Notices...............................................................11
  4.2 Financial Statements and Reports......................................11
    4.2.1 Annual Statements of Borrower.....................................11
    4.2.2 Periodic Statements...............................................11
    4.2.3 Accountant Letter.................................................11
    4.2.4 Description of Trends and Compliance..............................12
    4.2.5 Financial Statements; Reports; Notices, Etc. .....................12
    4.2.6 Data Requested; Annual Budget.....................................12
    4.2.7 Plan Events.......................................................12
    4.2.8 Intellectual Property Rights......................................12
  4.3 Existence.............................................................12
  4.4 Payment of Taxes and Other Obligations................................13
  4.5 Conduct of Business; Compliance With Law..............................13
  4.6 Insurance.............................................................13
  4.7 Recordkeeping; Rights of Inspection...................................13
  4.8 Prohibition of Fundamental Changes....................................13
  4.9 Contingent Liabilities................................................13
  4.10. Indebtedness........................................................14
  4.11 Liens................................................................14
  4.12 Bank Accounts........................................................15
  4.13 Costs and Expenses...................................................16
  4.14 Compliance with Legal Requirements...................................16
  4.15 Certain Borrower Financial Covenants.................................16
    4.15.1 Minimum Cash Coverage of Funded Debt.............................16
    4.15.2 Minimum Liquidity................................................16
    4.15.3 Minimum Tangible Net Worth.......................................17
    4.15.4 Profitability....................................................17
    4.15.5 Certain Definitions..............................................17

5. SPECIAL PROVISIONS.......................................................19

  5.1 Right to Contest......................................................19
    5.1.1 Taxes and Claims by Third Parties.................................19
  5.1.2 Legal Requirements..................................................19
  5.2 Revolving Credit Loans not Secured by Property........................19

6. CONDITIONS PRECEDENT.....................................................19

  6.1 Conditions of Initial Revolving Credit Loan...........................19
    6.1.1 Execution of Documents, Etc. .....................................19
    6.1.2 Proceedings; Receipt of Documents.................................19
    6.1.3 Legal Opinion.....................................................20
    6.1.4 Material Litigation...............................................20




                                     - ii -
<PAGE>   4

    6.1.5 No Material Adverse Effect........................................20
    6.1.6 Consents and Approvals............................................20
    6.1.7 Additional Matters................................................20
  6.2 Conditions of All Revolving Credit Loans..............................20
    6.2.1 Representations...................................................20
    6.2.2 Credit Limit Compliance...........................................20
    6.2.3 No Default........................................................20

7. EVENTS OF DEFAULT........................................................21

  7.1 Default and Events of Default.........................................21
    7.1.1 Generally.........................................................21
    7.1.2 Revolving Credit Note.............................................21
    7.1.3 Financial Status and Insolvency...................................21
    7.1.4 Breach of Representation or Warranty..............................22
    7.1.5 Plan Defaults.....................................................22
  7.2 Grace Periods and Notice..............................................22
    7.2.1 No Notice or Grace Period For Bankruptcy and Certain Covenants....22
    7.2.2 No Notice or Grace Period For Nonpayment of Interest and 
            Principal.......................................................22
    7.2.3 Other Monetary Defaults...........................................22
    7.2.4 Nonmonetary Defaults Capable of Cure..............................23
  7.3 Certain Lender Remedies...............................................23
    7.3.1 Accelerate Debt...................................................23
    7.3.2 Pursue Remedies...................................................23
    7.3.3 Termination of Commitment.........................................23
  7.4 Written Waivers.......................................................23

8. SECURITY INTEREST AND SET-OFF............................................23

  8.1 Security Interest.....................................................23
  8.2 Set-Off and Debit.....................................................23
  8.3 Right to Freeze.......................................................24
  8.4 Additional Rights.....................................................24

9. GENERAL PROVISIONS.......................................................24

  9.1 Notices...............................................................24
  9.2 Limitations on Assignment.............................................25
  9.3 Further Assurances....................................................25
  9.4 Parties Bound.........................................................26
  9.5 Waivers, Extensions and Releases......................................26
  9.6 GOVERNING LAW; CONSENT TO JURISDICTION; MUTUAL WAIVER Of JURY TRIAL...26
    9.6.1 Substantial Relationship..........................................26
    9.6.2 Place of Delivery.................................................26
    9.6.3 Governing Law.....................................................26
    9.6.4 Consent to Jurisdiction...........................................26
    9.6.5 JURY TRIAL WAIVER.................................................26
  9.7 Survival..............................................................27
  9.8 Cumulative Rights.....................................................27
  9.9 Claims Against Lender.................................................27
    9.9.1 Borrower Must Notify..............................................27
    9.9.2 Remedies..........................................................27
    9.9.3 Limitations.......................................................27





                                    - iii -
<PAGE>   5


    9.9.4 Indemnification...................................................28
  9.10 Obligations Absolute.................................................28
  9.11 Table of Contents, Title and Headings................................28
  9.12 Counterparts.........................................................28
  9.13 Satisfaction of Commitment; Termination of First Amendment...........28
  9.14 Right to Participate.................................................28
  9.15 Time Of the Essence..................................................29
  9.16 No Oral Change.......................................................29
  9.17 Monthly Statements...................................................29
  9.18 Confidentiality......................................................29










                                     - iv -
<PAGE>   6


                                CREDIT AGREEMENT

      CREDIT AGREEMENT ("Credit Agreement" or "Agreement") made and entered into
as of the 28th day of June, 1996, by and among GENZYME CORPORATION, a
Massachusetts corporation, having a principal place of business at Building
1400, One Kendall Square, Cambridge, Massachusetts 02139 ("Borrower") and FLEET
NATIONAL BANK, a national banking association, having an address at 75 State
Street, Boston, Massachusetts 02109 ("Lender").

                              W I T N E S S E T H:

      1.    BACKGROUND AND DEFINED TERMS.
            -----------------------------

      1.1   ORIGINAL AGREEMENT. Borrower and Fleet Bank of Massachusetts, N.A.
("Fleet-MA"), the predecessor to the Lender, entered into a Term Loan Agreement
dated as of June 13, 1994 (the "Term Loan Agreement") pursuant to which Lender
made a $21,500,000 secured term loan to Borrower (the "Term Loan").

      1.2   $15,000,000 REVOLVING LINE OF CREDIT. Borrower and Fleet-MA entered
into a First Amendment to Term Loan Agreement dated as of August 29, 1994 (the
"First Amendment") pursuant to which Fleet-MA made available to Borrower an
unsecured $15,000,000 line of credit (the "$15,000,000 Line of Credit"). The
term of the $15,000,000 Line of Credit was extended pursuant to a Second
Amendment to Term Loan Agreement dated as of August 31, 1995 (the "Second
Amendment).

      1.3   $215,000,000 LINE OF CREDIT. Borrower has requested that Lender 
provide it with an unsecured revolving line of credit in the aggregate amount of
$215,000,000, which will replace the $15,000,000 Line of Credit, and Lender has
agreed to do so, subject to the terms and conditions hereof.

      1.4   DEFINED TERMS. Capitalized terms used in this Credit Agreement have 
the meanings given such terms either in Schedule A or in specific sections of
this Agreement.

      2.    REVOLVING LINE OF CREDIT.
            -------------------------

      2.1   REVOLVING CREDIT COMMITMENT. Subject to the terms and conditions 
hereof, Lender agrees to make Revolving Credit Loans to Borrower from time to
time during the Revolving Credit Commitment Period, provided, however, that the
aggregate principal amount of all outstanding Revolving Credit Loans does not
exceed the Revolving Credit Commitment. The Revolving Credit Loans may be repaid
and reborrowed only during the Revolving Credit Commitment Period, and shall be
due and payable on the Revolving Credit Termination Date.

      2.2 PROCEDURE FOR REVOLVING CREDIT BORROWINGS. Subject to the terms and 
conditions hereof, Borrower may borrow under the Revolving Credit Commitment
during the Revolving 




                                      -1-
<PAGE>   7

Credit Commitment Period on any Business Day. Borrower may request Revolving
Credit Loans, from time to time, by submitting irrevocable Revolving Credit Loan
requests in such form and manner as Lender may require or permit (including,
without limitation, telephone requests, confirmed promptly in writing),
specifying, among other information, the amount to be borrowed, the requested
Borrowing Date, the interest rate mode (based on the Cost of Funds Rate or the
LIBO Rate, as provided in Section 2.3) selected by Borrower, the applicable
LIBOR Interest Period for any LIBOR Advance and the Maturity Date for any Cost
of Funds Advance, and the manner in which Borrower would like the proceeds of
such Revolving Credit Loan disbursed. If such Revolving Credit Loan request is
properly made and received by Lender prior to 10:00 a.m. (Eastern Time) on a
Business Day, requesting a Revolving Credit Loan on the next Business Day
following the Business Day upon which the request is made, Lender shall use
reasonable efforts to make the Revolving Credit Loan on the requested Business
Day. If, however, such Revolving Credit Loan request is received by Lender after
10:00 a.m. (Eastern Time) on a Business Day, Lender shall use reasonable efforts
to make the Revolving Credit Loan not later than the second Business Day
following the Business Day upon which the request was made. All telephone
requests shall be confirmed promptly in writing and Borrower shall indemnify and
hold Lender harmless for any action, including the making of any advance or any
actual loss or expenses taken or incurred by Lender in reliance upon any such
telephone request. Each borrowing pursuant to the Revolving Credit Commitment
shall be in the amount of $100,000 or an integral multiple thereof, provided
that any such borrowing, together with the aggregate principal amount of the
Revolving Credit Loans then outstanding, shall not exceed the Revolving Credit
Commitment then in effect. Except as otherwise requested, the proceeds of all
Revolving Credit Loans will be made available to Borrower by Lender by crediting
Borrower's deposit account with Lender.

      2.3 INTEREST ON REVOLVING CREDIT LOANS. The Borrower shall pay interest 
on the unpaid principal amount of the Revolving Credit Loans outstanding at
any time, and from time to time from the respective date such principal amounts
are advanced until paid (whether at stated maturity, on acceleration, or
otherwise) at an interest rate per annum equal to one of the following rates,
as elected by the Borrower as provided herein:

            2.3.1 LIBOR ADVANCES. For each LIBOR Advance made during the 
Initial Loan Period, the Adjusted LIBO Rate plus 62.5 basis points (0.625%),
and upon the first day following the Initial Loan Period and thereafter at the
Adjusted LIBO Rate plus 75 basis points (0.75%); and

            2.3.2 COST OF FUNDS ADVANCES. For each Cost of Funds Advance made 
during the Initial Loan Period, the Cost of Funds Rate plus 62.5 basis points
(0.625%), and upon the first day following the Initial Loan Period and
thereafter at the Cost of Funds Rate plus 75 basis points (0.75%);

provided, however, that upon the effective date of the reduction by Borrower
pursuant to Section 2.11 of the Revolving Credit Commitment to $25,000,000, the
interest rate payable on each LIBOR Advance made thereafter shall be the
Adjusted LIBO Rate plus 62.5 basis points 




                                      -2-
<PAGE>   8
(0.625%) and the interest rate on each Cost of Funds Advance made thereafter
shall be the Cost of Funds Rate plus 62.5 basis points (0.625%).

      2.4 PAYMENT OF INTEREST. Interest on Cost of Funds Advances, and 
Revolving  Credit Loans bearing interest at the Prime Rate, shall be payable in
arrears on the first day of each month commencing on July 1, 1996, and monthly
thereafter and, for Cost of Funds Advances, on the Maturity Date applicable
thereto or for Revolving Credit Loans bearing interest at the Prime Rate, when
such Revolving Credit Loans are repaid in full. Interest on LIBOR Advances
shall be payable in arrears on the first to occur of the last day of the
applicable LIBOR Interest Period or upon the prepayment of such LIBOR Advance.

      2.5 DEFAULT RATE. Notwithstanding anything to the contrary contained 
herein, after maturity (whether at the stated maturity, by acceleration after an
Event of Default or otherwise), interest shall be payable on the unpaid
principal balance of all outstanding Revolving Credit Loans at a rate that is
four percent (4%) in excess of the rate otherwise payable, until fully paid.

      2.6 REVOLVING CREDIT NOTE. The Revolving Credit Loans shall be evidenced 
by the Revolving Credit Note. Lender is hereby authorized to record the date and
amount of each (i) Revolving Credit Loan and (ii) payment or prepayment of
principal, on the schedule annexed to the Revolving Credit Note, or on such
related records maintained by Lender with respect to Revolving Credit Loans,
and, absent manifest error, any such notation shall constitute PRIMA FACIE
evidence of the accuracy of the information so recorded and in the event that
Borrower fails to object, within thirty (30) days of receipt of Lender's
periodic reports to Borrower with respect to Revolving Credit Loans, such
notations shall be conclusive and binding as against Borrower; PROVIDED,
HOWEVER, that any failure by Lender to make such notation on such schedule or
such related records shall not affect the obligations of Borrower under the
Revolving Credit Note or this Agreement.

      2.7 CALCULATION OF INTEREST. Interest and fees on Revolving Credit Loans 
shall be calculated on the basis of a 360-day year for the actual days elapsed,
from and including the date of each Revolving Credit Loan to but excluding the
date of any repayment. 

      2.8 INTEREST LIMITATION. No provision of this Agreement or the Revolving 
Credit Note shall require the payment, or permit the collection, of interest in
excess of the highest rate permitted by applicable law. To the extent that any
interest received by Lender exceeds the maximum amount permitted, such payment
shall be credited to unpaid principal, provided, however, that any excess amount
remaining after full payment of principal shall be refunded to Borrower.

      2.9 FEES. In addition to the fees set forth in the letter agreement of
even date between Borrower and Lender, Borrower agrees to pay the following:

            2.9.1 STRUCTURING FEE. The Borrower shall pay to the Lender a 
structuring fee equal to five (5) basis points on the initial Revolving Credit
Commitment ($107,500.00) of which $25,000.00 was fully earned and paid upon the
issuance by the Lender of its commitment 




                                      -3-
<PAGE>   9

letter dated June 13, 1996 relating to this credit facility and the balance of
$82,500.00 shall be fully earned and paid upon the Closing Date.

            2.9.2 UNDRAWN COMMITMENT FEE. Borrower agrees to pay to Lender an 
Undrawn Commitment Fee equal to twenty (20) basis points (.20%) per annum
calculated upon the amount by which the Revolving Credit Commitment exceeds the
average daily principal balance of the Revolving Credit Loans outstanding during
the immediately preceding fiscal quarter of Borrower (or part thereof), which
fee shall be payable quarterly in arrears on the first Business Day of each
fiscal quarter of Borrower.

            2.9.3 LATE PAYMENT CHARGE. Any payment of principal or interest on 
the Revolving Credit Loans not paid within ten (10) days after the date such
payment is due shall be subject to a late charge equal to five percent (5%) of
the amount overdue.

      2.10 PAYMENTS. All payments (including prepayments) made by Borrower 
hereunder or under the Revolving Credit Note shall be made in immediately
available funds not later than 2:00 p.m., (Eastern time), on the due date at
Lender's office located at 75 State Street, Boston, Massachusetts 02109 (or at
such other office as Lender may specify to Borrower in writing). If any payment
becomes due and payable on a day other than a Business Day, such payment shall
be extended to the next succeeding Business Day and, with respect to payments of
principal, interest thereon shall be payable at the applicable rate during such
extension. All payments shall be made without setoff or counterclaim and free
and clear of, and without deduction for, any charge of any kind. All payments
received by Lender after 2:00 p.m. on any Business Day shall not be deemed
received until the next Business Day. On the date any payment of principal or
interest is due on account of the Revolving Credit Loans, Lender will effect
payment by debiting Borrower's deposit accounts with Lender in an amount equal
to all or any portion of such payment due, but the failure of Lender to debit
Borrower's deposit accounts shall not relieve Borrower of its obligation to make
payments as required hereunder other than the Borrower's obligation to pay a
late payment charge under Section 2.9.4 if immediately available funds in the
amount required to make such payment were available at all times following the
payment date.

      2.11 REDUCTION IN REVOLVING CREDIT COMMITMENT. The Borrower shall have 
the  right to reduce the Revolving Credit Commitment at any time and from time
to time provided that (a) the Borrower shall give the Lender not less three (3)
Business Days notice of such reduction, (b) each reduction shall be in a
minimum amount of $5,000,000.00, (c) the Revolving Credit Commitment shall not
be reduced below $25,000,000.00 (the "Minimum Revolving Credit Commitment")
during the Revolving Credit Commitment Period, and (d) the Borrower shall not
reduce the Revolving Credit Limit unless, after giving effect to such
reduction, the Revolving Credit Commitment shall equal or exceed the aggregate
outstanding amount of the Revolving Credit Loans.



                                      -4-
<PAGE>   10


      2.12  PREPAYMENT.

            2.12.1 MANDATORY PREPAYMENT. If at any time the aggregate unpaid 
principal amount of the Revolving Credit Loans exceeds the Revolving Credit
Commitment, Borrower shall immediately pay an amount at least equal to such
excess, together with accrued interest on the amount paid to the date of payment
and the make-whole amount, if any, due under Section 2.13.

            2.12.2 VOLUNTARY PREPAYMENT. The Revolving Credit Loans may be 
prepaid in full or in part at any time upon three (3) Business Days prior
written notice to Lender, together with the payment of the make-whole amount,
if any, due under Section 2.13.

      2.13 MAKE WHOLE PROVISION. The Borrower shall pay to the Lender, 
immediately upon request and notwithstanding contrary provisions contained
herein, such amounts as shall, in the conclusive judgment of Lender (in the
absence of manifest error), compensate Lender for the loss, cost or expense
which it may reasonably incur as a result of (a) any payment or prepayment,
under any circumstances whatsoever, whether voluntary or involuntary, of all or
any portion of (i) a LIBOR Advance on a date other than the last day of the
applicable LIBOR Interest Period, or (ii) a Cost of Funds Advance on a date
other than the applicable Maturity Date for such Cost of Funds Advance, (b) the
failure of all or a portion of a Revolving Credit Loan pursuant to the request
of the Borrower to be advanced hereunder (except as a result of a failure by
Lender to fulfill Lender's obligations to fund), or (c) the failure of the
Borrower to borrow in accordance with any request submitted by it for a
Revolving Credit Loan. Such amounts payable by Borrower shall be equal to any
administrative costs actually incurred by Lender, plus any amounts required to
compensate Lender for any loss, cost or expense incurred by reason of the
liquidation or re-deployment of deposits or other funds acquired by Lender to
fund or maintain a Revolving Credit Loan plus, in any event a Yield Maintenance
Fee. The Yield Maintenance Fee shall be an amount equal to the product of: (a)
the amount so prepaid, not advanced or not borrowed, as the case may be,
multiplied by (b) the difference between the interest, then in effect, or which
would have been in effect (computed separately for each outstanding maturity or
installment), and the Treasury Rate in effect on the date of the occurrence
(computed separately for each outstanding maturity or installment) for such
Revolving Credit Loan, which product shall be multiplied by (c) a fraction, the
numerator of which is the number of days from the date of occurrence to the last
day of the applicable LIBOR Interest Period (or, if applicable, each LIBOR
Interest Period) with respect to LIBOR Advances and the Maturity Date (or, if
applicable, each Maturity Date) with respect to Cost of Funds Advances and the
denominator of which is 360 days; HOWEVER, if or to the extent that the
applicable interest rate for the applicable LIBOR Interest Period or the
applicable Maturity Date (computed separately for each maturity or installment),
as the case may be, is equal to or less than the Treasury Rate, no Yield
Maintenance Fee shall be payable.

      2.14 INCREASED COSTS. If, due to any one or more of: (i) the introduction 
after the date hereof of any applicable law or regulation or any change (other
than any change by way of imposition or increase of reserve requirements already
referred to in the definition of Adjusted 



                                      -5-
<PAGE>   11

LIBO Rate) in the interpretation or application by any authority charged with
the interpretation or application thereof of any law or regulation; or (ii) the
compliance with any guideline or request issued after the date hereof from any
governmental central bank or other governmental authority (whether or not having
the force of law), there shall be an increase in the cost to Lender of agreeing
to make or making, funding or maintaining Revolving Credit Loans, including,
without limitation, changes which affect or would affect the amount of capital
or reserves required or expected to be maintained by Lender, with respect to all
or any portion of the Revolving Credit Loans, or any corporation controlling
Lender, on account thereof, then the Borrower from time to time shall, upon
written demand by Lender, pay Lender additional amounts sufficient to indemnify
the Lender against the increased cost. A certificate as to the amount of the
increased cost and the reason therefor submitted to the Borrower by the Lender,
in the absence of manifest error, shall be conclusive and binding for all
purposes.

      2.15 ILLEGALITY. Notwithstanding any other provision of this Agreement or 
the Revolving Credit Note, if the introduction of or change in or in the
interpretation of any law, treaty, statute, regulation or interpretation thereof
shall make it unlawful, or any central bank or government authority shall assert
by directive guideline or otherwise, that it is unlawful, for Lender to make or
maintain Revolving Credit Loans with interest determined with reference to the
LIBO Rate or Cost of Funds Rate or to continue to fund or maintain Revolving
Credit Loans with interest determined with reference to the LIBO Rate or Cost of
Funds Rate then, on written notice thereof and demand by Lender to the Borrower,
(a) (i) the obligation of Lender to make such Revolving Credit Loans shall
terminate and (ii) all applicable outstanding Revolving Credit Loans shall bear
interest at the Prime Rate per annum, or (b) at Borrower's option, Borrower
shall immediately repay such Revolving Credit Loans in full plus the make-whole
amount, if any, due under Section 2.13.

      2.16 ADDITIONAL ADVANCE CONDITIONS. The making of Revolving Credit Loans 
under Section 2.1 and the maintenance of LIBOR Advances shall be subject to the
following additional terms and conditions:

            2.16.1 AVAILABILITY. If Lender notifies the Borrower that:

            (a)   dollar deposits in the amount and for the maturity requested 
are not available to Lender in the London interbank market, or

            (b)   reasonable means do not exist for Lender to determine the LIBO
Rate for the amounts and maturity requested or, upon selection by Borrower of a
Maturity Date, the Cost of Funds Rate as determined pursuant to Section 2.3.2.

then the principal which would have been a LIBOR Advance shall bear interest at
the Prime Rate per annum.

            2.16.2 PAYMENTS NET OF TAXES. All payments and prepayments of 
principal and interest on any LIBOR Advance be made net of any taxes and costs
resulting from having principal and interest outstanding at or computed with
reference to a LIBO Rate. Without 



                                      -6-
<PAGE>   12


limiting the generality of the preceding obligation, such taxes and costs
include taxes, or the withholding of amounts for taxes, of any nature whatsoever
including income, excise, interest equalization taxes (other than United States
or state income taxes) as well as all levies, imposts, duties or fees whether
now in existence or as the result of a change in or promulgation of any treaty,
statute, regulation, or interpretation thereof or any directive guideline or
otherwise by a central bank or fiscal authority (whether or not having the force
of law) or a change in the basis of, or the time of payment of, such taxes and
other amounts resulting therefrom.

            2.16.3 SUCCESSOR LIBOR INTEREST PERIOD NOT SELECTED. At the end of 
each applicable LIBOR Interest Period for each LIBOR Advance, unless Borrower
selects another LIBOR Interest Period or elects to convert the borrowing to a
Cost of Funds Advance in accordance with the provisions of this Agreement, the
LIBOR Advance shall bear interest at the Prime Rate.

            2.16.4 SUCCESSOR COST OF FUNDS MATURITY DATE NOT SELECTED. At the 
Maturity Date for each Cost of Funds Advance, unless Borrower has properly
notified Lender to extend the Cost of Funds Advance and designated a new
Maturity Date or to convert the Cost of Funds Advance to a LIBOR Advance, the
Cost of Funds Advance shall continue with successive Maturity Dates of seven (7)
days until any such notification is received and effective.

      3.   REPRESENTATIONS AND WARRANTIES. Borrower represents and warrants to 
Lender for the express purpose of inducing Lender to enter into this Agreement
and to make the Revolving Credit Loans hereunder as follows:

      3.1 FINANCIAL INFORMATION. The Financial Statements of Borrower that have 
been delivered to Lender are true, accurate and complete in all material
respects and the same fairly present the financial condition of Borrower as of
the dates thereof and the results of operations, shareholder's equity and cash
flows for the periods then ended. No event or circumstance has occurred which
would have a Material Adverse Effect on such financial condition since the dates
of such Financial Statements. All Financial Statements of Borrower hereafter
furnished to Lender shall have been prepared in accordance with GAAP, except as
otherwise disclosed therein, subject only in the case of unaudited interim
financial statements to normal year end audit adjustments and limited or no
footnote disclosures, and shall be true, accurate and complete and shall fairly
present the financial condition of Borrower as of the dates thereof.

      3.2 NO VIOLATIONS. The borrowing of the Revolving Credit Loans and the 
subsequent payment and performance of the Obligations evidenced by this
Agreement and the Revolving Credit Note shall not constitute a violation of, or
conflict with, any law, order, regulation, indenture, contract or agreement to
which Borrower is a party or by which Borrower, or the property and assets
thereof, may be bound, or of the charter and by-laws of, or any security issued
by, Borrower.

      3.3 NO LITIGATION. There is no material litigation now pending, or to the 
best of Borrower's knowledge threatened, against Borrower in which there is a
reasonable possibility 




                                      -7-
<PAGE>   13


of an adverse decision that would materially impair the ability of Borrower to
pay and perform its obligations hereunder or under the Revolving Credit Note.

      3.4 USE OF PROCEEDS. The proceeds of the Revolving Credit Loans shall be 
used to acquire the assets of Deknatel Snowden Pencer, Inc. and for Borrower's
and its Subsidiaries' working capital needs and other general business purposes.

      3.5 ORGANIZATION. Borrower is a duly organized and validly existing 
corporation in good standing under the laws of The Commonwealth of
Massachusetts. Borrower is duly qualified and in good standing as a foreign
corporation in each jurisdiction where the nature of its business is such that
the failure to so qualify would reasonably be expected to have a Material
Adverse Effect.

      3.6 DUE AUTHORITY. Borrower has all requisite power and authority to 
conduct its business and to own its property, as now conducted or owned, and as
contemplated by this Agreement.

      3.7 AUTHORIZATION.  All required corporate actions and proceedings have 
been duly taken so as to authorize the execution and delivery by Borrower of
this Agreement and the Revolving Credit Note.

      3.8 VALID AND BINDING. This Agreement had the Revolving Credit Note 
constitute the legal, valid and binding obligations of Borrower in accordance
with the terms hereof and thereof, but in each instance subject to bankruptcy,
insolvency and similar laws of general application affecting the rights and
remedies of creditors and, with respect to the availability of equitable
remedies, subject to the discretion of the court before which any proceeding
therefor may be brought.

      3.9 IRC AND ERISA. All Plans which are pension plans as defined in 
Section 3(2) of ERISA, shall qualify under Section 401(a) of the IRC, and all
Plans have been and shall be in compliance with the provisions of the IRC and
ERISA, and have been and shall be administered in accordance with their terms.
Except with respect to events which would not have a Material Adverse Effect on
Borrower: (a) none of the Plans has participated in, engaged in or been a party
to any non-exempt "prohibited transaction" as defined in Section 406 of ERISA
or Section 4975(c) of the IRC, and no officer, director or employee of Borrower
or other Person for whose conduct Borrower may be responsible has committed a
breach of any of the responsibilities or obligations imposed upon fiduciaries
by Title I of ERISA; (b) there are no material claims, pending or threatened,
involving any Plan by a current or former employee (or beneficiary thereof) of
Borrower, nor is there any reasonable basis to anticipate any material claims
involving any such Plans; (c) there have been no violations of any reporting or
disclosure requirements with respect to any Plan and no such Plan has violated
applicable law, including but not limited to ERISA and the IRC; (d) no Plan
which is a defined benefit pension plan has (i) incurred a material unfunded
post service liability, a material excess of "benefit liabilities" over the
fair market value of Plan assets, or any "accumulated funding deficiency"
(within the meaning of Section 412(a) of the IRC), whether or not waived, (ii)
been a Plan with respect to 





                                      -8-
<PAGE>   14


which a Reportable Event (to the extent that the reporting of such events to the
PBGC within thirty (30) days of the occurrence has not been waived) has occurred
and is continuing, or (iii) been a Plan with respect to which there exist
conditions or events which have occurred presenting a risk of termination by
PBGC; (e) no Plan which is a Multiemployer Plan to which Borrower contributes or
has contributed has been a Plan with respect to which Borrower has received any
notification that such Multiemployer Plan is in reorganization or has been
terminated within the meaning of Title IV of ERISA and no such Multiemployer
Plan is reasonably expected to be in reorganization or to be terminated within
the meaning of Title IV of ERISA, and Borrower has not withdrawn from, or
incurred any withdrawal liability to, any Multiemployer Plan; (f) there has been
no violation of the applicable requirements of Section 4980B of the IRC
pertaining to COBRA continuation coverage with respect to any Plan; and (g) no
Plan which is a medical, dental, health, disability, insurance or other
"employee welfare benefit plan" as defined in Section 3(1) of ERISA, has any
unfunded accrued liability or provides benefits to former employees or retirees
(except as may be required by COBRA).

      3.10 NO DEFAULT. Borrower is not in default under any order, award or 
decree of any court, arbitrator or governmental authority binding upon or
affecting Borrower or by which any of Borrower's properties may be bound or
affected which, if not cured within any applicable cure period, would have a
Material Adverse Effect on Borrower, and no such order, award or decree has a
Material Adverse Effect on Borrower. There is no Default by Borrower hereunder
and no event has occurred and is continuing which could constitute a Default
hereunder. Borrower is not in default under any indenture, agreement or
instrument evidencing or securing any outstanding Indebtedness for borrowed
money or Capital Lease Obligation of Borrower.

      3.11 TAXES. All federal, state, local and other tax reports and returns 
which are required to be filed by Borrower have been filed, except where
extensions have been properly obtained, and Borrower has paid or made adequate
provision for all taxes, interest and penalties shown to be due and payable on
such returns or on any assessments made against Borrower or any of Borrower's
properties in which the failure to pay would have a Material Adverse Effect on
Borrower, and no tax liens have been filed and no claims are being asserted with
respect to any such taxes, fees or other charges (except as may be subject to
contest as set forth in Section 5.1.1 of this Agreement).

      3.12 INTELLECTUAL PROPERTY RIGHTS. Except with respect to events or 
matters which are not reasonably expected to have a Material Adverse Effect on
Borrower, (a) Borrower owns or licenses all material Intellectual Property
necessary for the conduct of its business as presently conducted; (b) all
material agreements pursuant to which Borrower licenses the manufacture,
marketing or sale of products employing its Intellectual Property are in full
force and effect; (c) no claims, demands, suits, or proceedings are pending or
threatened which impair Borrower's rights in any material Intellectual Property
used in the conduct of Borrower's business or any material agreement relating
thereto; and (d) Borrower has not infringed any Intellectual Property of any
other Person, and the present conduct of Borrower's business does not infringe
any such rights.




                                      -9-
<PAGE>   15

      3.13 CONSENTS; NO BURDENSOME AGREEMENTS. No consent, or authorization of, 
filing with, or notice to, any governmental entity or any other Person is or
shall be required in connection with the execution, delivery or performance by
Borrower, or the validity or enforceability against Borrower, of this Agreement
or the Revolving Credit Note. Borrower is not a party to or bound by any
agreement or instrument or subject to any corporate restriction (including any
restriction set forth in its charter or by-laws) that is reasonably expected to
have a Material Adverse Effect.

      3.14 COMPLIANCE WITH LAWS INCLUDING ENVIRONMENTAL AND SAFETY MATTER. 
Borrower is in compliance in all material respects with all Legal Requirements
including, without limitation, all environmental, health and safety statutes and
regulations and specifically the Federal Food, Drug and Cosmetic Act, the
Federal Resource Conservation and Recovery Act, the Federal Comprehensive
Environmental Response, Compensation and Liability Act, the Federal Clean Water
Act, the Clean Air Act, the requirements and regulations of the Nuclear
Regulatory Commission, the Federal Occupational Safety and Health Act and
Massachusetts General Laws, Chapters 21C and 21E and the regulations promulgated
thereunder. To the knowledge of Borrower, Borrower is not subject to any
material judicial or administrative proceedings alleging the violation of any
applicable law or regulation. Borrower is not the subject of any federal, state
or local investigation regarding, among other matters, the release of any
Hazardous Material into the environment, the results of which would reasonably
be likely to materially and adversely affect Borrower's financial condition,
operations, business or prospects. Borrower does not have, any contingent
liabilities in connection with any release of any Hazardous Material into the
environment which would reasonably be likely to materially and adversely affect
Borrower's financial condition, operations, businesses or prospects.

      3.15  NO LIENS. There are no liens on the Borrower's or its Subsidiaries' 
properties, except as permitted under Section 4.11.

      3.16 REGULATION U, ETC. Borrower is not and shall not engage, principally 
or as one of its important activities, in the business of extending credit for
the purpose of "purchasing" or "carrying" any "margin stock" (within the
respective meanings of each of the quoted terms under Regulations G, T, U or X
of the Board of Governors of the Federal Reserve System and any successors
thereto as now and from time to time hereafter in effect), and no portion of the
proceeds of the Revolving Credit Loans hereunder will be used (a) for
"purchasing" or "carrying" any "margin stock" as so defined or to extend credit
to others for the purpose thereof, or to repay or refund Indebtedness previously
incurred for that purpose, or (b) for any purpose which violates, or which would
be inconsistent with, the provisions of the regulations of the Federal Reserve
System including, without limitation, Regulations G, T, U and X thereof.

      3.17 INVESTMENT COMPANY ACT, ETC. Borrower is not and shall not be an 
"investment company" registered or required to be registered under the
Investment Company Act of 1940, or a company "controlled" (within the meaning of
such Investment Company Act) by such an "Investment Company". Borrower is not
and shall not be subject to regulation under the Public Utility Holding Company
Act of 1935, the Federal Power Act, the Interstate Commerce Act, 




                                      -10-
<PAGE>   16

Massachusetts General Laws, Chapter 164 or to any other federal or state statute
or regulation limiting its ability to incur indebtedness for money borrowed.

      3.18 BACKGROUND INFORMATION AND CERTIFICATES. The factual information 
contained in the financial statements, reports, SEC filings, certificates and
opinions furnished to Lender by or on behalf of Borrower in connection with the
Property or the Loan, is, or shall be, as of the respective dates thereof, true,
accurate and complete in all material respects, and, except for certificates
which are intended to be limited in scope, does not, and shall not, omit any
material fact necessary to make the same not misleading in any material respect.

      3.19 CONTINUOUS NATURE OF REPRESENTATIONS AND WARRANTIES. Each 
representation or warranty contained in this Agreement shall be continuous in
nature and shall remain accurate, complete and not misleading at all times
during the term of this Agreement, except for changes in the nature of
Borrower's and its Subsidiaries' business or operations which would not render
the information contained herein or in any disclosure schedule hereto
inaccurate, incomplete or misleading or which are expressly permitted hereunder.

      4.    COVENANTS. From the date hereof and so long as the Revolving Credit 
Commitment remains in effect, or any of the Revolving Credit Loans or other
Obligations remain outstanding, the Borrower covenants and agrees, unless the
Lender shall otherwise consent in writing, as follows:

      4.1 NOTICES. Borrower shall, with reasonable promptness, but in all 
events  within ten (10) days after it has actual knowledge thereof, notify
Lender in writing of the occurrence of any act, event or condition which
constitutes a Default hereunder. Such notification shall include a written
statement of any remedial or curative actions which Borrower proposes to
undertake to cure or remedy such Default.

      4.2 FINANCIAL STATEMENTS AND REPORTS. Borrower shall furnish or cause to 
be furnished to Lender from time to time, the following financial statements and
reports and other information:

            4.2.1 ANNUAL STATEMENTS OF BORROWER. As soon as available, but in 
any event not later than ninety (90) days after the end of each fiscal year of
Borrower, Financial Statements of Borrower for such fiscal year;

            4.2.2 PERIODIC STATEMENTS. As soon as available, but in any event 
not later than forty-five (45) days after the end of each of the first three (3)
fiscal quarters of each fiscal year of Borrower, Financial Statements of
Borrower for such fiscal quarter;

            4.2.3 ACCOUNTANT LETTER. When received by Borrower, a copy of the 
management letter of Borrower's accountants addressed to its Board of Directors,
if such letter is prepared;


                                      -11-
<PAGE>   17

            4.2.4 DESCRIPTION OF TRENDS AND COMPLIANCE. (i) Simultaneously with 
delivery of the Financial Statements, a copy of Borrower's Form 10-Q or 10-K
filing made for the periods covered by the Financial Statements required
hereunder, or, if such filings are not available, a brief narrative description
of material business and financial trends and developments and significant
transactions that have occurred in the period or periods covered thereby,
together with (ii) a Compliance Certificate as of the date of such Financial
Statements, in the form attached as EXHIBIT B hereto;

            4.2.5 FINANCIAL STATEMENTS; REPORTS; NOTICES, ETC. As and when 
issued, copies of all (i) financial statements, reports, notices and proxy
statements sent to shareholders of Borrower; (ii) press releases and other
statements generally made available by Borrower to the public, customers or the
trade concerning material developments in the businesses of Borrower; and (iii)
regular, periodic and special reports and registration statements or other
official statements and prospectuses (and all amendments and supplements
thereto) required to be filed by Borrower with the Securities and Exchange
Commission or any successor thereto under Sections 13(a) or 15 of the Securities
Exchange Act of 1934.

            4.2.6 DATA REQUESTED; ANNUAL BUDGET. Within a reasonable period of 
time and from time to time such other financial data or information as Lender
may reasonably request with respect to the Borrower. Within a reasonable period
of time after the end of each fiscal year of Borrower, Borrower, at Lender's
request, will meet with Lender to discuss Borrower's anticipated financial
results and business prospects for the current year.

            4.2.7 PLAN EVENTS. Borrower shall give Lender notice of the 
following events, as soon as possible and in any event within five (5) days
after any officer of Borrower obtains knowledge thereof: (i) Borrower's failure
to make any required payment to any Plan in sufficient amount to comply with
ERISA and the IRC on or before the due date for such payment; (ii) the
occurrence or expected occurrence of any Reportable Event, "prohibited
transaction" or "accumulated funding deficiency" with respect to any Plan; (iii)
receipt by Borrower of any notice (A) from a Multiemployer Plan regarding the
imposition of withdrawal liability; or (B) of the institution, or expectancy of
the institution, of any proceeding or any other action which may result in the
termination of any Plan, or Borrower's withdrawal or partial withdrawal from any
Plan.

            4.2.8 INTELLECTUAL PROPERTY RIGHTS. Within thirty (30) days of 
obtaining knowledge thereof, Borrower shall provide Lender with a written notice
and reasonable description of any events or conditions which, if they existed
and were known to Borrower on the date of this Agreement, would have violated
the warranty and representation made in Section 3.12 (dealing with Intellectual
Property Rights).

      4.3 EXISTENCE. Borrower shall preserve and keep in full force and effect 
its corporate existence and all franchises, licenses, permits and approvals
material to the conduct of its business.




                                      -12-
<PAGE>   18
 
     4.4 PAYMENT OF TAXES AND OTHER OBLIGATIONS. Subject to the rights to 
contest set forth in Section 5.1, Borrower shall duly pay and discharge, or
cause to be paid and discharged, before the same shall become overdue, all
taxes, assessments and other governmental charges payable by it, or with respect
to its property and assets, and shall duly pay all Indebtedness for borrowed
money as such becomes due and payable.

      4.5 CONDUCT OF BUSINESS; COMPLIANCE WITH LAW. Borrower shall continue to 
be engaged principally in the biotechnology, pharmaceutical and diagnostic
services businesses. Borrower shall operate its business and conduct its affairs
in a lawful manner and in compliance with all material Legal Requirements
applicable thereto.

      4.6 INSURANCE. Borrower shall maintain insurance with responsible 
companies in such amounts and against such risks as is usually carried by
similar businesses.

      4.7 RECORDKEEPING; RIGHTS OF INSPECTION. Borrower shall (i) keep proper 
books of record and account at its Cambridge, Massachusetts headquarters or at
its offices in Framingham, Massachusetts or at any other location in
Massachusetts, upon written notice to Lender, in which full, true and correct
entries, in conformity with GAAP, are made of all dealings and transactions in
relation to its properties, business and activities; (ii) permit Persons
authorized by Lender to visit and inspect its books of record and account and to
discuss the affairs, finances and accounts of Borrower with its officers and
independent public accountants, all at such times during normal business hours
after reasonable prior notice and as often as Lender may reasonably request; and
(iii) permit Lender to perform audits of such books and records of account, at
Lender's expense prior to the occurrence of a Default and, thereafter at
Borrower's expense.

      4.8 PROHIBITION OF FUNDAMENTAL CHANGES. Borrower shall not (a) enter into 
any transaction of merger or consolidation or liquidate, wind-up or dissolve
itself (or allow any such liquidation or dissolution) except (upon prior written
notice to Lender if the transaction is reportable to the Securities and Exchange
Commission), a merger or consolidation in which the Borrower is the surviving
entity and which, giving effect to the merger or consolidation, would not result
in a breach of the covenants contained in Section 4.15 (which deals with certain
financial covenants); or (b) convey, sell, exchange, lease, assign, transfer or
otherwise dispose of all or substantially all of its assets or, without the
prior written consent of Lender not to be unreasonably withheld, any material
assets, whether now owned or held or hereafter acquired, except in the ordinary
course of business and as customary in the biotechnology, pharmaceutical and
diagnostic services industries (which exceptions may include, without
limitation, currency and interest rate hedging transactions and licensing of
patents and product rights).

      4.9 CONTINGENT LIABILITIES. Borrower and its Consolidated Subsidiaries 
shall not create, incur, assume or allow to exist any Contingent Liability in
excess of $10,000,000 (without duplication), in the aggregate, at any one time
outstanding, (other than the existing Contingent Liabilities set forth on
Schedule 4.9) without the prior written consent of the Lender, which shall not
be unreasonably withheld.



                                      -13-
<PAGE>   19

      4.10 INDEBTEDNESS. At all times that the Revolving Credit Commitment 
exceeds the Minimum Revolving Credit Commitment, the Borrower will not create,
incur or suffer to exist any Indebtedness EXCEPT:

            (a)  Indebtedness to the Lender hereunder;

            (b)  Indebtedness outstanding on the initial Borrowing Date and set
forth in the Financial Statements furnished to Lender and any renewals,
extensions or refinancings thereof provided that such renewals, extensions or
refinancings shall not increase the amount of such Indebtedness or provide any
collateral security for it, and not mature prior to the original maturity of
such Indebtedness;

            (c)  Indebtedness under or in respect of currency exchange contracts
or interest rate protection obligations incurred in the ordinary course of
business;

            (d)  Indebtedness in connection with performance bonds or letters of
credit obtained and issued in the ordinary course of business, including letters
of credit related to insurance associated with claims for work-related injuries;

            (e)  Indebtedness with respect to Liens permitted under Section
4.11(d);

            (f)  Indebtedness in an amount not to exceed $30,000,000.00 incurred
to finance the construction of a manufacturing facility and acquisition of
equipment for the Genzyme Tissue Repair Division;

            (g)  Indebtedness in an amount not to exceed $10,000,000.00 
incurred to finance the business and operations of Genzyme (UK) Limited;

            (h)  Indebtedness, the payment of which is subordinated to the
payment of the Revolving Credit Loans and other Obligations hereunder in a
manner reasonably satisfactory to Lender; and

            (i)  Other unsecured Indebtedness of the Borrower in an aggregate
principal amount at any time outstanding not to exceed $10,000,000.

      4.11 LIENS. Borrower will not create or suffer to exist any Lien upon any 
of its property or assets, now owned or hereafter acquired, securing any
Indebtedness, except Liens:

            (a)  for taxes, assessments or governmental charges or levies on
property if the same shall not at the time be delinquent or thereafter can be
paid without penalty or interest, or are being contested pursuant to Section 5.1
hereof;

            (b)  imposed by law, such as carriers', warehousemen's and 
mechanics' liens, bankers' set-off rights and other similar liens arising in the
ordinary course of business for sums 


                                      -14-
<PAGE>   20

not yet due or being contested in good faith by appropriate proceedings
diligently conducted and for which proper reserves or other provision has been
made in accordance with GAAP;

            (c) arising in the ordinary course of business out of pledges or
deposits under worker's compensation laws, unemployment insurance, old age
pensions, or other social security or retirement benefits, or similar
legislation;

            (d) incurred as purchase money Liens or other Liens of a conditional
vendor sale or refundings thereof on fixed or capital assets acquired or held by
Borrower to secure the purchase price of such property; provided that the Liens
permitted by this clause (d) shall (i) at all times be confined solely to the
property so purchased, and (ii) secure Indebtedness which does not exceed the
lower of the fair market value on the date of purchase or the cost of the
property so purchased;

            (e) Liens on the Genzyme Tissue Repair manufacturing facility and
equipment securing the repayment of Indebtedness permitted under Section
4.10(f);

            (f) Liens on the assets of Genzyme (UK) Limited securing the 
repayment of the Indebtedness permitted under Section 4.10(g);

            (g) arising from or upon any judgment or award, provided that such
judgment or award is being contested in good faith by proper appeal proceedings,
such judgment or aware is not secured by any Lien which is not discharged within
thirty (30) days, and only so long as execution thereon shall be stayed;

            (h) those now or hereafter granted to the Lender;

            (i) deposits to secure the performance of bids, trade contracts, and
bonds, performance bonds and other obligations of a like nature incurred in the
ordinary course of any of the Borrower's businesses;

            (j) easements, rights of way, restrictions and other similar
encumbrances incurred in the ordinary course of business which, in the
aggregate, are not material in amount, and which do not in any case materially
detract from the value of the property subject thereto or interfere with the
ordinary conduct of business by the Borrower; and

            (k) security interests and liens existing on the date hereof and set
forth on Schedule 4.11 hereto.

      4.12 BANK ACCOUNTS. Borrower has established and shall maintain a demand 
(checking) account with Lender, which account shall be used for making payments
due on the Revolving Credit Loans.

      Lender is hereby authorized, on or after the due date, to charge such
account, or any other deposit account of Borrower at Lender, with the amount of
all payments due under this 



                                      -15-
<PAGE>   21

Agreement or the Revolving Credit Note. Borrower agrees to have sufficient
collected funds in its account at Lender to enable Lender to charge such account
for each payment due under this Agreement and the Revolving Credit Note on the
due date thereof. The failure of Lender to so charge such account shall not
affect or limit Borrower's obligation to make any required payment.

      4.13 COSTS AND EXPENSES. Borrower shall pay all reasonable out-of-pocket 
costs and expenses reasonably incurred by Lender in connection with: (i) the
arrangement, documentation, closing and funding of the Revolving Credit Loans,
(ii) responding to any requests from Borrower for approvals, consents or formal
changes under or with respect to this Agreement, and (iii) in connection with
the determination and enforcement of Lender's rights under this Agreement or the
Revolving Credit Note, including, without limitation, reasonable legal fees and
disbursements, reasonable appraisal fees, inspection fees, plan review fees,
reasonable fees and out-of-pocket costs of Lender and its agents and
consultants. Borrower's obligations to pay such costs and expenses shall
include, without limitation, all reasonable attorneys' fees and other costs and
expenses reasonably incurred for preparing and conducting litigation or dispute
resolution arising from any breach by Borrower of any covenant, warranty,
representation or agreement under any one or more of the Loan Documents.

      4.14 COMPLIANCE WITH LEGAL REQUIREMENTS. Borrower shall comply with all 
material provisions of ERISA and all other material Legal Requirements
applicable to the Borrower, subject to the right to contest set forth in Section
5.1.

      4.15  CERTAIN BORROWER FINANCIAL COVENANTS.

      4.15.1 MINIMUM CASH COVERAGE OF FUNDED DEBT. Borrower and its wholly-owned
Subsidiaries shall maintain a ratio of (A) unrestricted and unpledged cash, Cash
Equivalents and Marketable Securities, to (B) Funded Debt, of (C) not less than
the ratio set forth below as determined on the last day of the following fiscal
quarters:

                            Period                          Ratio
                            ------                          -----

             Fiscal Quarter Ended June 30, 1996             1.0:1.0

             Fiscal Quarter Ended September 30, 1996        .95:1.0

             Thereafter at each Fiscal Quarter End          1.0 to 1.0

provided, however, that upon the reduction by Borrower pursuant to Section 2.11
of the Revolving Credit Commitment to the Minimum Revolving Credit Commitment,
the foregoing ratio shall be 1.1 to 1.0, as determined on the last day of each
fiscal quarter of Borrower thereafter.

      4.15.2 MINIMUM LIQUIDITY. Borrower and its Consolidated Subsidiaries 
shall maintain a ratio of (A) cash and Cash Equivalents, plus Marketable
Securities, plus Accounts Receivable, to 



                                      -16-
<PAGE>   22

(B) Current Liabilities plus Total Long Term Senior Liabilities, of (C) .85 to
1.0 as determined on the last day of each fiscal quarter of Borrower; provided,
however that upon the reduction by Borrower pursuant to Section 2.11 of the
Revolving Credit Commitment to the Minimum Revolving Credit Commitment, the
foregoing ratio shall be 1.5 to 1.0, as determined on the last day of each
fiscal quarter of Borrower thereafter.

      4.15.3 MINIMUM TANGIBLE NET WORTH. Borrower and its Consolidated 
Subsidiaries shall maintain a Tangible Net Worth of not less than
$350,000,000.00, as determined on the last day of each fiscal quarter of
Borrower.

      4.15.4  PROFITABILITY. Borrower and its Consolidated Subsidiaries shall 
have minimum quarterly Operating Income of $10,000,000.00 and minimum fiscal
year Operating Income of $50,000,000.00.

      4.15.5 CERTAIN DEFINITIONS.

      (i) "ACCOUNTS RECEIVABLE" shall mean, on any date the net amount of
accounts receivable of Borrower and its Consolidated Subsidiaries, excluding any
such accounts which are more than 120 days old, after deducting all returns,
discounts and allowances thereon and reserves relating thereto, determined in
accordance with GAAP.

      (ii) "CASH EQUIVALENTS" - shall mean any interest bearing investment of
Borrower and (x) its wholly-owned Subsidiaries in respect of the Minimum Cash
covenant set forth in Section 4.15.1, or (y) its Consolidated Subsidiaries for
all other purposes, which meets the definition of a "cash equivalent" under GAAP
(i.e. purchased with a remaining maturity of 90 days or less). Such investments
shall be at least investment grade (A1/P1 for commercial paper, BBB or better
for bonds and similar investments).

      (iii) "CONSOLIDATED NET INCOME" shall mean, for any period, the net income
(or deficit) of Borrower and its Consolidated subsidiaries determined in
accordance with GAAP on a Consolidated basis; provided, however, that
Consolidated Net Income shall not include: (a) all amounts included in computing
net income (or deficit) in respect of the write-up of any asset (other than
marketable securities) after December 31, 1995; and (b) extraordinary and
nonrecurring gains or losses as determined in accordance with GAAP.

      (iv) "CONSOLIDATED NET WORTH" - shall mean, at any date, the shareholder's
equity of the Borrower and its Consolidated Subsidiaries determined in
accordance with GAAP on a Consolidated basis;

      (v) "CURRENT LIABILITIES" - shall mean any liability that in accordance
with GAAP would be classified as such.

      (vi) "FUNDED DEBT" - shall mean the outstanding balance of all
Indebtedness in respect of borrowed money, letters of credit and trade
acceptances (excluding however Subordinated Debt).



                                      -17-
<PAGE>   23

      (vii) "INDEBTEDNESS" - shall mean with respect to Borrower and its
Consolidated Subsidiaries, any item that would properly be included as a
liability on the liability side of a balance sheet as of any date as of which
Indebtedness is to be determined and includes (but is not limited to) (a) all
obligations for borrowed money, (b) all obligations evidenced by bonds,
debentures, notes or other similar instruments, (c) all obligations to pay the
deferred purchase price of property or services, (d) all Capital Lease
Obligations and (e) all obligations in respect of advances under letters of
credit issued for such Person's account and in respect of acceptances of drafts
drawn by such Person.

      (viii) "MARKETABLE SECURITIES" shall mean any interest bearing debt
obligations owned by (x) Borrower and its wholly-owned Subsidiaries for the
purpose of Section 4.15.1, and (y) and for all other purposes by Borrower and
its Consolidated Subsidiaries (excluding directors' qualifying shares) of
Borrower (without duplication of items included as Cash Equivalents) which meet
the definition of marketable securities under GAAP. Such amounts shall exclude
common or preferred stock. Such securities shall include obligations issued by
the U.S. Treasury and other agencies of the U.S. government, corporate bonds,
bank notes, mortgage and asset backed securities, finance company securities,
and auction rate preferred stocks. Such securities shall be rated investment
grade (BBB or better for bonds or similar securities, A1/P1 for commercial paper
and notes) and which are otherwise reasonably liquid investments.

      (ix) "OPERATING INCOME" shall mean the Consolidated Net Income of Borrower
and its Consolidated Subsidiaries without deduction for taxes, interest expense,
interest income, income attributable to minority interests held by Borrower and
the before-tax effects of non-operating non-cash items including, but not
limited to, write-off of acquired technology or acquired research and
development, which, in accordance with GAAP, may be charged to income.

      (x) "SUBORDINATED DEBT" shall mean Indebtedness of Borrower and its
Subsidiaries that by its terms is fully subordinated to the payment and
enforcement of the Loans in a manner reasonably satisfactory to Lender.

      (xi) "TANGIBLE NET WORTH" shall mean the Consolidated Net Worth of
Borrower less all intangible assets of the Borrower and its Consolidated
Subsidiaries determined in accordance with GAAP on a Consolidated basis plus all
indebtedness of the Borrower that is subordinated to the full repayment of the
Obligations in a manner satisfactory to Lender.

      (xii) "TOTAL LONG TERM SENIOR LIABILITIES" shall mean all Indebtedness of
the Borrower and its Consolidated Subsidiaries on a Consolidated basis,
excluding Current Liabilities and Indebtedness which is Subordinated Debt.





                                      -18-
<PAGE>   24

      5.    SPECIAL PROVISIONS.

      5.1   RIGHT TO CONTEST.

      5.1.1 TAXES AND CLAIMS BY THIRD PARTIES.-- Notwithstanding the provisions 
of Section 3.4 which obligate Borrower to pay taxes and other charges when due,
it is agreed that any tax, assessment, charge, levy, claim or such obligation to
a third party (expressly excluding an obligation created hereunder) need not be
paid while the validity or amount thereof shall be contested currently,
diligently and in good faith by appropriate proceedings and if Borrower shall
have adequate unencumbered and unrestricted cash reserves with respect thereto
and provided that Borrower shall pay all taxes, assessments, charges, levies or
other such obligations immediately upon the imposition of any Lien on the assets
or properties of Borrower.

      5.1.2 LEGAL REQUIREMENTS. Borrower may contest any claim, demand, levy or 
assessment under any Legal Requirements by any Person if: (i) the contest is
based upon a material question of law or fact raised by Borrower in good faith;
(ii) Borrower properly commences and thereafter diligently pursues the contest;
(iii) the contest will not materially impair the ability to ultimately comply
with the contested Legal Requirement should the contest not be successful; and
(iv) no Event of Default exists.

      5.2 REVOLVING CREDIT LOANS NOT SECURED BY PROPERTY. Lender and Borrower 
acknowledge and agree that notwithstanding any provision to the contrary in the
Original Agreement or the Mortgage or the Security Agreement entered into
thereunder, the Revolving Credit Loans and the Borrower's obligations under this
Agreement shall not be secured by the Mortgage from Borrower, the Security
Documents or other collateral listed in Sections 3.1 of the Original Agreement
and the term "obligations" as used in the Mortgage shall not include Borrower's
obligations under the Revolving Credit Note and this Credit Agreement.
Accordingly, Lender may not foreclose on the Property subject to the Mortgage,
exercise any of its other remedies under the Mortgage or otherwise seek to
realize upon any of such Collateral in order to satisfy Borrower's Obligations
to it under this Agreement or the Revolving Credit Note.

      6.    CONDITIONS PRECEDENT.

      6.1 CONDITIONS OF INITIAL REVOLVING CREDIT LOAN. The obligation of the 
Lender to make the initial Revolving Credit Loans hereunder is subject to the
fulfillment of the following conditions precedent, each of which shall have been
fulfilled to the satisfaction of the Lender:

            6.1.1 EXECUTION OF DOCUMENTS, ETC. This Agreement, the Revolving 
Credit Note and any other agreements, documents and instruments to be executed
and/or delivered in connection herewith and therewith (collectively the "Loan
Documents") shall have been duly and properly authorized, executed and delivered
by the respective party or parties thereto and shall be in full force and
effect;

            6.1.2 PROCEEDINGS; RECEIPT OF DOCUMENTS. All requisite corporate 
action and proceedings in connection with the execution and delivery of this
Agreement, the Revolving 



                                      -19-
<PAGE>   25

Credit Note and the other Loan Documents shall be satisfactory in form and
substance to the Lender and its counsel, and the Lender and its counsel shall
have received all information and copies of all documents, including without
limitation, records of requisite corporate action and proceedings which the
Lender or its counsel may have requested in connection therewith, such documents
where requested by the Lender or its counsel to be certified by appropriate
persons or governmental authorities;

            6.1.3 LEGAL OPINION. Lender shall have received and approved a 
legal opinion letter from counsel representing Borrower;

            6.1.4 MATERIAL LITIGATION. There shall be no pending or, to the 
best knowledge of the Borrower, threatened litigation with respect to the
Borrower before any court, arbitrator or governmental or administrative body or
agency which challenges or relates to (i) the transactions contemplated hereby
or (ii) the Loan Documents;

            6.1.5 NO MATERIAL ADVERSE EFFECT. In the judgment of the Lender (a)
no event or circumstance shall have occurred in the financial condition of the
Borrower from that reflected in the financial statements of the Borrower most
recently furnished to Lender that is reasonably likely to have a Material
Adverse Effect and (b) no Default or Event of Default shall have occurred and be
continuing;

            6.1.6 CONSENTS AND APPROVALS. Borrower shall have obtained and 
furnished to Lender all consents and approvals of other Persons required for
Borrower to enter into this Agreement and to borrow hereunder; and.

            6.1.7 ADDITIONAL MATTERS. Lender shall have received such other 
documents, statements, certificates, information and evidence as Lender may
reasonably request.

      6.2 CONDITIONS OF ALL REVOLVING CREDIT LOANS. The Lender's obligation to 
make any Revolving Credit Loan including the initial Revolving Credit Loans
hereunder is subject to the fulfillment of the following conditions precedent:

            6.2.1 REPRESENTATIONS. The representations and warranties made by 
the Borrower in any Loan Document shall be true and correct in all material
respects on and as of the Borrowing Date for such Revolving Credit Loan as if
made on and as of such date;

            6.2.2 CREDIT LIMIT COMPLIANCE. The aggregate unpaid principal 
amount  of the Revolving Credit Loans outstanding on any Borrowing Date shall
not exceed the Revolving Credit Commitment then in effect on such date; and

            6.2.3 NO DEFAULT. No Default or Event of Default shall exist or 
have occurred and be continuing.



                                      -20-
<PAGE>   26

      7.    EVENTS OF DEFAULT. The following provisions deal with Default, 
Events of Default, notice, grace and cure periods, and certain rights of Lender
following an Event of Default.

      7.1 DEFAULT AND EVENTS OF DEFAULT. The term "Default" as used herein 
shall  mean an Event of Default, or any fact or circumstance which constitutes,
or upon the lapse of time, or giving of notice, or both, would constitute, an
Event of Default. Each of the following events, unless cured within any
applicable grace period set forth or referred to below in this Section 7.1., or
in Section 7.2., shall constitute an "Event of Default":

      7.1.1 GENERALLY. A default by Borrower in the performance of any term, 
provision or condition of this Agreement to be performed by Borrower, or a
breach, or other failure to satisfy, any other term, provision, condition,
covenant or warranty under this Agreement and such default remains uncured
beyond any applicable specific grace period provided for in this Agreement, or
as set forth in Section 7.2. below;

      7.1.2 REVOLVING CREDIT NOTE. A default by Borrower in the performance of 
any term or provision of the Revolving Credit Note, or a breach, or other
failure to satisfy, any other term, provision, condition or warranty under the
Revolving Credit Note, regardless of whether or not the Lender has adequate
security to cover any payment of money required thereby, and the specific grace
period, if any, allowed for the default in question shall have expired without
such default having been cured;

      7.1.3 FINANCIAL STATUS AND INSOLVENCY. Borrower shall: (i) admit in 
writing its inability to pay its debts generally as they become due; (ii) file a
petition in bankruptcy or a petition to take advantage of any insolvency act;
(iii) make a general assignment for the benefit of creditors; (iv) consent to,
or acquiesce in, the appointment of a receiver, liquidator or trustee of itself
or of the whole or any substantial portion of its properties or assets; (v) file
a petition or answer seeking reorganization, arrangement, composition,
readjustment, liquidation, dissolution or similar relief under the Federal
Bankruptcy laws or any other applicable law; (vi) have a court of competent
jurisdiction enter an order, judgment or decree appointing a receiver,
liquidator or trustee of Borrower, or of the whole or any substantial portion of
the property or assets of Borrower, and such order, judgment or decree shall
remain unvacated or not set aside or unstayed for sixty (60) days; (vii) have a
petition filed against it seeking reorganization, arrangement, composition,
readjustment, liquidation, dissolution or similar relief under the Federal
Bankruptcy laws or any other applicable law and such petition shall remain
undismissed for sixty (60) days; (viii) have, under the provisions of any other
law for the relief or aid of debtors, any court of competent jurisdiction assume
custody or control of Borrower or of the whole or any substantial portion of its
property or assets and such custody or control shall remain unterminated or
unstayed for sixty (60) days; (ix) have an attachment or execution in an amount
greater than $1,000,000 in the aggregate levied against any of the assets or
properties of Borrower, or in an amount greater than $10,000,000 in the
aggregate against the whole or any substantial portion of the property of
Borrower, or any attachment in an amount greater than $1,000,000 against any
portion of the properties or assets of Borrower which is not discharged or
dissolved by a bond (or cash collateral acceptable to Lender) within thirty (30)
days; or (x) have a judgment entered 



                                      -21-
<PAGE>   27

against it which is not subject to further appeal in an amount greater than
$1,000,000 in the aggregate for matters related to the assets or properties of
Borrower, or greater than $10,000,000 in the aggregate whether or not related to
the assets or properties of Borrower is not paid in full or otherwise satisfied
within thirty (30) days.

      7.1.4 BREACH OF REPRESENTATION OR WARRANTY. Any material representation 
or  warranty made by Borrower herein or in any other instrument or document
relating to the Revolving Credit Loans shall at any time be materially false or
misleading when made, or any warranty shall be materially breached;

      7.1.5 PLAN DEFAULTS. The Borrower or any Commonly Controlled Entity shall 
fail to pay when due amounts (other than amounts being contested in good faith
through appropriate proceedings and in accordance with Section 5.1) which it
shall become liable to pay to the PBGC or to a Plan; or notice of intent to
terminate a Plan shall be filed by Borrower or any Commonly Controlled Entity or
administrator; or the PBGC shall institute proceedings to terminate or cause a
trustee to be appointed to administer any Plan or a proceeding shall be
instituted by a fiduciary of any Plan against Borrower or any Commonly
Controlled Entity to enforce Section 515 or 4219(c)(5) of ERISA; or a condition
shall exist which would require the PBGC to obtain a decree adjudicating that
any Plan must be terminated.

      7.2 GRACE PERIODS AND NOTICE. As to each of the foregoing events the 
following provisions relating to grace periods and notice shall apply:

      7.2.1 NO NOTICE OR GRACE PERIOD FOR BANKRUPTCY AND CERTAIN COVENANTS.  
There shall be no grace period and no notice provision with respect to: (i) the
payment of principal at maturity; (ii) defaults related to the voluntary filing
of bankruptcy or reorganization proceedings or an assignment for the benefit of
creditors; (iii) nonmonetary defaults which are not reasonably capable of being
cured;(iv) a breach of warranty or representation under Sections 3.1. (regarding
Financial Information), 3.4 (Use of Proceeds), 3.5, 3.6, 3.7 (Entity Matters),
3.8 (Valid and Binding), 3.16 (Regulation U) and 3.17 (Investment Company Act);
or (v) breaches under Sections 4.1 (Notices), 4.8 (Prohibition of Fundamental
Changes), 4.9 (Contingent Liabilities), 4.10 (Restriction on Indebtedness), 4.11
(Restriction on Liens) and 4.15 (Financial Covenants).

      7.2.2 NOTICE OR GRACE PERIOD FOR NONPAYMENT OF INTEREST AND PRINCIPAL. As
to the nonpayment of interest and principal prior to maturity, there shall be a
one (1) Business Day grace period without any requirement of notice, but
Borrower shall not be entitled to such grace period more than once in any
consecutive twelve month period.

      7.2.3 OTHER MONETARY DEFAULTS. All other monetary defaults shall have a 
five (5) day grace period following notice from Lender, or, if shorter, a grace
period without notice until five (5) Business Days before the last day on which
payment is required to be made in order to avoid the cancellation or lapse of
required insurance, or as to municipal taxes and charges, to avoid late charges
or penalties.

                                      -22-
<PAGE>   28

      7.2.4 NONMONETARY DEFAULTS CAPABLE OF CURE. As to nonmonetary defaults 
which are reasonably capable of being cured or remedied, unless there is a
specific shorter or longer grace period provided for in this Agreement, there
shall be a thirty (30) day grace period, without requirement of notice from
Lender or, if such default would reasonably require more than thirty (30) days
to cure or remedy, such longer period of time not to exceed a total of ninety
(90) days from the date of default as may be reasonably required so long as
Borrower shall commence reasonable actions to remedy or cure the default within
thirty (30) days following the date of default and shall diligently prosecute
such curative action to completion within such ninety (90) day period. However,
where there is an emergency situation in which there is danger to person or
property such curative action shall be commenced as promptly as possible. As to
breaches of warranties and representations (other than those specified in
Section 7.2.1 above) there shall be a thirty (30) day grace period following the
first to occur of (a) Borrower's knowledge of the breach, or (b) notice from
Lender to Borrower with respect to the breach.

      7.3 CERTAIN LENDER REMEDIES. If an Event of Default shall exist, Lender:

      7.3.1 ACCELERATE DEBT. May declare the indebtedness evidenced by the 
Revolving Credit Note to be immediately due and payable provided that in the
case of a voluntary petition in bankruptcy filed by Borrower, or an involuntary
petition in bankruptcy filed against Borrower which is not dismissed as herein
provided, such acceleration shall be automatic;

      7.3.2 PURSUE REMEDIES. May pursue any and all remedies provided for 
hereunder, or available to Lender at law or in equity; and

      7.3.3 TERMINATION OF COMMITMENT. May declare all obligations of Lender to 
Borrower, including, without limitation, the Revolving Credit Commitment to be
terminated, whereupon such obligations and the Revolving Credit Commitment shall
terminate; provided, however, that upon the occurrence of a Default under
Section 7.1.3, the Revolving Credit Commitment shall terminate immediately.

      7.4 WRITTEN WAIVERS. If a Default or an Event of Default is waived by 
Lender, in its sole discretion, pursuant to a specific written instrument 
executed by an authorized officer of Lender, the Default or Event of Default 
so waived shall be deemed to have never occurred.

      8.    SECURITY INTEREST AND SET-OFF.

      8.1 SECURITY INTEREST. Borrower hereby grants to Lender a direct and 
continuing lien and security interest, as security for all of Borrower's
Obligations in and upon all deposits, balances and other sums credited by or due
from Lender, or from any affiliate of Lender, to Borrower.

      8.2 SET-OFF AND DEBIT. (i) If any payment is not made when due hereunder 
or under the Revolving Credit Note, or (ii) if any Event of Default or other
event which would entitle Lender to accelerate the Revolving Credit Loans
occurs, or (iii) at any time, whether or not any Default or Event of Default
exists, in the event any attachment, trustee process, garnishment, or 



                                      -23-
<PAGE>   29

other levy or lien is, or is sought to be, imposed on any property of Borrower;
then, in any such event, any such deposits, balances or other sums credited by
or due from Lender, or from any such affiliate of Lender, to Borrower may to the
fullest extent not prohibited by applicable law at any time or from time to
time, without regard to the existence, sufficiency or adequacy of any other
collateral, and without notice or compliance with any other condition precedent
now or hereafter imposed by statute, rule of law or otherwise, all of which are
hereby waived, be set off, debited and appropriated, and applied by Lender
against any or all of Borrower's Obligations irrespective of whether demand
shall have been made and although such Obligations may be unmatured, in such
manner as Lender in its sole and absolute discretion may determine. Within two
(2) Business Days of making any such set off, debit or appropriation and
application, Lender agrees to notify Borrower thereof, provided the failure to
give such notice shall not affect the validity of such set off, debit or
appropriation and application.

      8.3 RIGHT TO FREEZE. Lender shall also have the right, at its option, 
upon  the occurrence of any event which would entitle Lender to set off or
debit as set forth in Section 8.2, to freeze, block or segregate any such
deposits, balances and other sums so that Borrower may not access, control or
draw upon the same.

      8.4 ADDITIONAL RIGHTS. The rights of Lender and each affiliate of Lender 
under this Section 8 are in addition to, and not in limitation of, other rights
and remedies, including other rights of set off, which Lender may have.

      9.    GENERAL PROVISIONS.

      9.1 NOTICES. Any notice or other communication in connection with this 
Agreement or the Revolving Credit Note, shall be in writing, and (i) deposited
in the United States Mail, postage prepaid, by registered or certified mail, or
(ii) hand delivered by any commercially recognized courier service or overnight
delivery service such as Federal Express, or (iii) sent by facsimile
transmission, if a FAX Number is designated below, provided a copy is also sent
by first-class mail addressed:

      If to Borrower:

                        GENZYME CORPORATION
                        One The Mountain Road
                        Framingham, Massachusetts 01701
                        FAX Number: 508-872-0827
                        Attention: Evan M. Lebson, Treasurer




                                      -24-
<PAGE>   30

with copies by regular mail, or such hand delivery or facsimile transmission
to:

                        Palmer & Dodge
                        One Beacon Street
                        Boston, Massachusetts 02108
                        FAX Number: 617-227-4420
                        Attention: Maureen P. Manning, Esquire

      If to Lender:

                        Fleet National Bank
                        75 State Street
                        Boston, Massachusetts 02109
                        FAX Number: 617-346-1633
                        Attention: High Tech Group

with copies by regular mail, or such hand delivery or facsimile transmission
to:

                        Brown Rudnick Freed & Gesmer
                        One Financial Center
                        Boston, Massachusetts 02111
                        FAX Number: (617) 856-8201
                        Attention: Peter D. Gens, Esq.

Any such addressee may change its address for such notices to such other address
in the United States as such addressee shall have specified by written notice
given as set forth above. All periods of notice shall be measured from the
deemed date of delivery.

A notice shall be deemed to have been given, delivered and received for the
purposes of this Agreement and the Revolving Credit Note upon the earliest of:
(i) if sent by such certified or registered mail, on the third Business Day
following the date of postmark, or (ii) if hand delivered at the specified
address by such courier or overnight delivery service, when so delivered or
tendered for delivery during customary business hours on a Business Day, or
(iii) if so mailed, on the date of actual receipt as evidenced by the return
receipt, or (iv) if so delivered, upon actual receipt or (v) if facsimile
transmission is a permitted means of giving notice, upon receipt as evidenced by
confirmation.

      9.2 LIMITATIONS ON ASSIGNMENT. Borrower may not assign this Agreement or 
the monies due thereunder or any interest therein without the prior written
consent of Lender in each instance.

      9.3 FURTHER ASSURANCES. Borrower shall upon request from Lender from time 
to time execute, seal, acknowledge and deliver such further instruments or
documents which Lender may reasonably require to better perfect and confirm its
rights and remedies hereunder and under the Revolving Credit Note.


                                      -25-
<PAGE>   31

      9.4 PARTIES BOUND. The provisions of this Agreement and of the Revolving 
Credit Note shall be binding upon and inure to the benefit of Borrower and
Lender and their respective successors and assigns, except as otherwise
prohibited by this Agreement. This Agreement is a contract by and between
Borrower and Lender for their mutual benefit, and no third person shall have any
right, claim or interest against either Lender or Borrower by virtue of any
provision hereof.

      9.5 WAIVERS, EXTENSIONS AND RELEASES. Lender may at any time and from 
time  to time waive any one or more of the conditions contained herein, but any
such waiver, extension or release shall be deemed to be made in pursuance and
not in modification hereof, and any such waiver in any instance, or under any
particular circumstance, shall not be considered a waiver of such condition in
any other instance or any other circumstance.

      9.6  GOVERNING LAW; CONSENT TO JURISDICTION; MUTUAL WAIVER Of JURY TRIAL.

      9.6.1 SUBSTANTIAL RELATIONSHIP. It is understood and agreed that the 
Agreement and the Revolving Credit Note were negotiated, executed and delivered
in the Commonwealth of Massachusetts, which Commonwealth the parties agree has a
substantial relationship to the parties and to the underlying transactions
embodied herein.

      9.6.2 PLACE OF DELIVERY. Borrower agrees to furnish to Lender at the 
Lender's office in Boston, Massachusetts all further instruments, certifications
and documents to be furnished hereunder.

      9.6.3 GOVERNING LAW. This Agreement and the Revolving Credit Note shall 
in all respects be governed, construed, applied and enforced in accordance with
the internal laws of The Commonwealth of Massachusetts without regard to
principles of conflicts of law.

      9.6.4 CONSENT TO JURISDICTION. Borrower hereby consents to personal 
jurisdiction in any state or Federal court located within the Commonwealth of
Massachusetts.

      9.6.5 JURY TRIAL WAIVER. BORROWER AND LENDER MUTUALLY HEREBY KNOWINGLY, 
VOLUNTARILY AND INTENTIONALLY WAIVE THE RIGHT TO A TRIAL BY JURY IN RESPECT OF
ANY LITIGATION BASED ON THIS AGREEMENT, ARISING OUT OF, UNDER OR IN CONNECTION
WITH THIS AGREEMENT OR THE REVOLVING CREDIT NOTE CONTEMPLATED TO BE EXECUTED IN
CONNECTION HEREWITH, OR ANY COURSE OF CONDUCT, COURSE OF DEALINGS, STATEMENTS
(WHETHER VERBAL OR WRITTEN) OR ACTIONS OF ANY PARTY. THIS WAIVER CONSTITUTES A
MATERIAL INDUCEMENT FOR BORROWER AND LENDER TO ENTER INTO THE TRANSACTIONS
CONTEMPLATED HEREBY.


                                      -26-
<PAGE>   32


      9.7 SURVIVAL. All representations, warranties, covenants and agreements 
of  Borrower herein or in any other Loan Document, or in any notice,
certificate, or other paper delivered by or on behalf of Borrower pursuant
hereto are significant and shall be deemed to have been relied upon by Lender
notwithstanding any investigation made by Lender or on its behalf and shall
survive the delivery of this Agreement and the making of the Revolving Credit
Loans. No review or approval by Lender, or by its consultants or
representatives, of any plans and specifications, opinion letters, certificates
by professionals or other item of any nature shall relieve Borrower or anyone
else of any of the obligations, warranties or representations made by or on
behalf of Borrower hereunder.

      9.8 CUMULATIVE RIGHTS. All of the rights of Lender hereunder and any 
other  instrument or agreement now or hereafter executed in connection herewith
or therewith, shall be cumulative and may be exercised singly, together, or in
such combination as Lender may determine in its sole good faith judgment.

      9.9 CLAIMS AGAINST LENDER.

            9.9.1 BORROWER MUST NOTIFY. Lender shall not be liable for a 
default  under this Agreement, unless a written notice specifically setting
forth the claim of Borrower shall have been given to Lender within sixty (60)
days after Borrower first had actual knowledge or actual notice of the
occurrence of the event which Borrower alleges gave rise to such claim and
Lender does not remedy or cure the default, if any there be, with reasonable
promptness thereafter. Such actual knowledge or actual notice shall refer to
what was actually known by, or expressed in a written notification furnished
to, any of the persons or officials referred to in SCHEDULE B as Authorized
Representatives or of the Chief Executive Officer, Chief Financial Officer, or
Treasurer.

            9.9.2 REMEDIES. If it is determined by the final order of a court 
of  competent jurisdiction, which is not subject to further appeal, that Lender
has breached any of its obligations hereunder and has not remedied or cured the
same with reasonable promptness following notice thereof, Lender's
responsibilities shall be limited to: (i) where the breach consists of the
failure to grant consent or give approval in violation of the terms and
requirements hereof, the obligation to grant such consent or give such approval
and to pay Borrower's reasonable costs and expenses including, without
limitation, reasonable attorneys' fees and disbursements in connection with
such court proceedings; and (ii) in the case of any such failure to grant such
consent or give such approval, or in the case of any other such default by
Lender, where it is also so determined that Lender acted in bad faith, or that
Lender's default constituted gross negligence or willful misconduct, the
payment of any actual, direct, compensatory damages sustained by Borrower as a
result thereof plus Borrower's reasonable costs and expenses, including,
without limitation, reasonable attorneys' fees and disbursements in connection
with such court proceedings.

            9.9.3 LIMITATIONS. In no event, however, shall Lender be liable to 
Borrower or to anyone else for other damages such as, but not limited to,
indirect, speculative or punitive damages whatever the nature of the breach by
Lender of its obligations under this Agreement. In 




                                      -27-
<PAGE>   33

no event shall Lender be liable to Borrower or to anyone else unless a written
notice specifically setting forth the claim of Borrower shall have been given to
Lender within the time period specified above.

            9.9.4 INDEMNIFICATION. Borrower agrees to indemnify and hold Lender 
harmless from and against any and all loss, liability, damages, penalties,
claims, actions, costs and expenses (including, without limitation, reasonable
attorneys' fees and disbursements) now or at any time in the future incurred or
asserted against Lender by any Person arising out of or in connection with this
Agreement or the Revolving Credit Note or any of the transactions contemplated
hereby, except to the extent that a court of competent jurisdiction determines
pursuant to a final judgment that is not subject to further appeal in a
proceeding in which Lender is a proper party that such loss or claim arose out
of the gross negligence or willful misconduct of Lender.

      9.10 OBLIGATIONS ABSOLUTE. Except to the extent prohibited by applicable 
law which cannot be waived, the Obligations of Borrower hereunder shall be
absolute, unconditional and irrevocable and shall be paid strictly in accordance
with the terms hereunder all circumstances whatsoever, including, without
limitation, the existence of any claim, set off, defense or other right which
Borrower, or any Affiliate thereof, may have at any time against Lender whether
in connection with the Loan or any unrelated transaction, except for any such
claim, setoff, defense or other right, if any, as to which a written notice
shall have been given to Lender in accordance with the provisions of Section
9.9.

      9.11 TABLE OF CONTENTS, TITLE AND HEADINGS. Any Table of Contents, the 
titles and the headings of sections are not parts of this Agreement and shall
not be deemed to affect the meaning or construction of any of its provisions.

      9.12 COUNTERPARTS. This Agreement may be executed in several 
counterparts, each of which when executed and delivered is an original, but
all of which together shall constitute one instrument. In making proof of this
agreement, it shall not be necessary to produce or account for more than one
such counterpart which is executed by the party against whom enforcement of
such loan agreement is sought.

      9.13 SATISFACTION OF COMMITMENT; TERMINATION OF FIRST AMENDMENT. The 
Revolving Credit Loans being made pursuant to the terms hereof is being made in
satisfaction of Lender's obligations under the commitment letter dated June 13,
1996. The terms, provisions and conditions of this Agreement supersede and
replace the provisions of that letter commitment and the First Amendment and the
Second Amendment.

      9.14 RIGHT TO PARTICIPATE. Lender reserves the right to transfer and 
assign the Revolving Credit Loans and Revolving Credit Commitment, or portions
thereof, or participation interests therein, but no such transfer or sale of
participation interests shall affect or limit the rights and obligations of
Lender and Borrower as set forth in this Agreement. In connection with any sale
of participation interests or assignments thereof: (a) each such participation
in the Revolving Credit Commitment shall be in a minimum amount of $25,000,000,
(b) any 




                                      -28-
<PAGE>   34


assignment by a participant of an interest in the Revolving Credit Commitment
shall be in a minimum amount of $10,000,000, (c) the Lender shall retain for its
own account at least $25,000,000 of the Revolving Credit Commitment and may
charge an assignment fee, payable by participants and assignees, of $2,500 for
each such transfer, and (d) all such participations and assignments shall be
subject to the consent of Borrower, which consent shall not be unreasonably
withheld or delayed. Lender may disclose to, or share with, any actual or
prospective transferee, participant or assignee all information, including, but
not limited to, financial information, in Lender's possession regarding the
Revolving Credit Loans or the Borrower.

      9.15  TIME OF THE ESSENCE. Time is of the essence of each provision of 
this Agreement.

      9.16 NO ORAL CHANGE. This Credit Agreement may only be amended, 
terminated, extended or otherwise modified by a writing signed by the party
against which enforcement is sought (except no such writing shall be required
for any party which, pursuant to a specific provision here, is required to be
bound by changes without such party's assent). In no event shall any oral
agreements, promises, actions, inactions, knowledge, course of conduct, course
of dealings or the like be effective to amend, terminate, extend or otherwise
modify this Agreement.

      9.17 MONTHLY STATEMENTS. While Lender may issue invoices or other 
statements on a monthly or periodic basis (a "Statement"), it is expressly
acknowledged and agreed that: (i) the failure of Lender to issue any Statement
on one or more occasions shall not affect Borrower's obligations to make
payments under this Agreement and the Revolving Credit Note as and when due;
(ii) the inaccuracy of any Statement shall not be binding upon Lender and so
Borrower shall always remain obligated to pay the full amount(s) required under
this Agreement and the Revolving Credit Note as and when due notwithstanding any
provision to the contrary contained in any Statement (but no Default shall
result unless Borrower shall have notice of such inaccuracy); (iii) all
Statements are issued for information purposes only and shall never constitute
any type of offer, acceptance, modification, or waiver of this Agreement and the
Revolving Credit Note or any of Lender's rights or remedies thereunder; and (iv)
in no event shall any Statement serve as the basis for, or a component of, any
course of dealing, course of conduct, or trade practice which would modify,
alter, or otherwise affect the express written terms of this Agreement and the
Revolving Credit Note.

      9.18 CONFIDENTIALITY. Lender shall not divulge to others any non-public 
information obtained from Borrower or its Affiliates in connection with this
Agreement and shall not use such information for any purpose not contemplated
hereby, except in connection with Legal Requirements and in connection with
enforcing its rights and remedies under this Agreement and the Revolving Credit
Note and in the conduct, operation and regulation of its banking and lending
business (which may include, without limitation, the transfer of the Revolving
Credit Loans or of participation interests therein as provided in Section 9.14).
Any transferee of the Loan or any holder of a participation interests in the
Loan shall be entitled to deal with such information in the same manner and in
connection with any subsequent transfer of its interest in the Loan or of
further participation interests therein, subject in each case to the
restrictions set forth herein.




                                      -29-
<PAGE>   35

      IN WITNESS WHEREOF this Agreement has been duly executed and delivered as
a sealed instrument at Boston, Massachusetts as of the date first above written.


                                    BORROWER:

                                    GENZYME CORPORATION


                                    By: /s/ David J. McLachlan
                                       -------------------------------------- 
                                       David J. McLachlan
                                       Senior Vice President, Finance


                                    LENDER:

                                    FLEET NATIONAL BANK


                                    By: /s/ Catherine M. Bruton
                                       -------------------------------------- 
                                       Catherine M. Bruton, Vice President


                                    By: /s/ William Rurode
                                       -------------------------------------- 
                                       William Rurode, Senior Vice President





                                      -30-
<PAGE>   36

                             SCHEDULES AND EXHIBITS:
                             -----------------------


                                                          Section Reference
                                                          -----------------
                                                          Number
                                                          ------

Schedule A         Definitions                            1.4
- ----------
Schedule B         Authorized Representatives             9.9.1
- ----------
Schedule 4.9       Contingent Liabilities                 4.9
- ------------
Schedule 4.11      Existing Liens                         4.11
- -------------
Exhibit A          Revolving Credit Note                  2.6
- ---------
Exhibit B          Form of Compliance Certificate         4.2.4
- ---------



                                      -31-
<PAGE>   37


                         SCHEDULE A TO CREDIT AGREEMENT
                         ------------------------------

                                   DEFINITIONS
                                   -----------


ACCOUNTS RECEIVABLE as defined in Section 4.15.5(i).

ADJUSTED LIBO RATE means for each LIBOR Interest Period the rate per annum
obtained by dividing (i) the LIBO Rate for such LIBOR Interest Period, by (ii) a
percentage equal to one hundred percent (100%) minus the maximum reserve
percentage applicable during such LIBOR Interest Period under regulations issued
from time to time by the Board of Governors of the Federal Reserve System for
determining the maximum reserve requirements (including, without limitation, any
basic, supplemental, marginal and emergency reserve requirements) for Lender (or
of any subsequent holder of the Revolving Credit Note which is subject to such
reserve requirements) in respect of liabilities or assets consisting of or
including Eurocurrency liabilities (as such term is defined in Regulation D of
the Board of Governors of the Federal Reserve System) having a term equal to the
LIBOR Interest Period.

AFFILIATE means as to any Person (a) any other Person which, directly or
indirectly, is in control of, is controlled by or is under common control with
such Person or (b) any other Person who is a director or officer (i) of such
Person or (ii) of any Person described in clause (a) above. For purposes hereof,
control of a Person shall mean the power, direct or indirect, (i) to vote
thirty-three percent (33%) or more of the securities having the right to vote
for the election of directors of such Person or (ii) to direct or cause the
direction of the management and policies of such Person, whether by contract or
otherwise and either alone or in conjunction with others.

AGREEMENT as defined in the Preamble.

AUTHORIZED REPRESENTATIVES as listed on SCHEDULE B.

BORROWER as defined in the Preamble.

BORROWING DATE means the Business Day on which any Revolving Credit Loan is
made.

BUSINESS DAY means: any day of the year on which offices of Fleet National Bank
are not required or authorized by law to be closed for business in Boston,
Massachusetts. If any day on which a payment is due is not a Business Day, then
the payment shall be due on the next day following which is a Business Day.
Further, if there is no corresponding day for a payment in the given calendar
month (i.e., there is no "February 30th"), the payment shall be due on the last
Business Day of the calendar month. If the applicable Business Day relates to
the selection or determination of any LIBO Rate, the term Business Day means any
London Banking Day. If any day on which a payment on a Revolving Credit Loan is
due is not a Business Day, then the payment shall be due on the next day
following which is a Business Day, unless, with respect to such Revolving Credit
Loan, the effect would be to make the payment due in the next calendar




                                      -1-
<PAGE>   38


month, in which event such payment shall be due on the next preceding day which
is a Business Day.

CASH EQUIVALENT as defined in Section 4.15.5(ii).

CAPITAL LEASE means any lease of property by Borrower or any of its
Subsidiaries, as lessee, that, in accordance with GAAP, would be capitalized on
its balance sheet.

CAPITAL LEASE OBLIGATIONS means the aggregate capitalized amount of the
obligations of Borrower and its Subsidiaries under all Capital Leases.

CLOSING DATE means the date that the Lender determines that the conditions
precedent in Section 6 to the initial Revolving Credit Loans have been satisfied
or determines that such conditions may be waived.

COBRA means the Consolidated Omnibus Budget Reconciliatory Act of 1985, as
amended, including the sections of the IRC affected by it and all regulations
promulgated under such Act or the IRC.

COMMONLY CONTROLLED ENTITY means an entity, whether or not incorporated, which
is under common control with Borrower within the meaning of Section 414(b) or
(c) of the IRC.

CONSOLIDATED and CONSOLIDATING means, when used with reference to any term, that
term (or the terms "combined" and "combining", as the case may be, in the case
of partnerships, joint ventures and Affiliates that are not Subsidiaries) as
applied to the accounts of Borrower (or any other specified Person) and all of
its Subsidiaries (or other specified Persons) or such of its Subsidiaries as may
be specified, consolidated (or combined) in accordance with GAAP and with
appropriate deductions for minority interests in Subsidiaries, if required by
GAAP.

CONSOLIDATED NET INCOME as defined in Section 4.15.5(iii).

CONSOLIDATED NET WORTH as defined in Section 4.15.5(iv).

CONTINGENT LIABILITY means any obligation of a Person guaranteeing or in effect
guaranteeing any Indebtedness, leases, dividends or other obligations ("primary
obligations") of any other Person (the "primary obligor") in any manner, whether
directly or indirectly, including, without limitation, any obligation of such
Person, whether or not contingent, (a) to purchase any such primary obligation
or asset constituting direct or indirect security therefor, (b) to advance or
supply funds (i) for the purchase or payment of any such primary obligation or
(ii) to maintain working capital or equity capital of the primary obligor or
otherwise to maintain the net worth or solvency of the primary obligor, (c) to
purchase property, securities or services primarily for the purpose of assuring
the owner or holder of any such primary obligation of the ability of the primary
obligor to make payment of such primary obligation or (d) otherwise to assure or
hold harmless the owner or holder of such primary obligation against loss in
respect thereof; PROVIDED, HOWEVER, that the term Contingent Liability shall not
include (x) guaranties of any primary 




                                      -2-
<PAGE>   39

obligation of an Affiliate of Borrower, or (y) endorsements of negotiable
instruments in the ordinary course of business or agreements to indemnify other
Persons against liabilities arising out of collaboration with or service
provided to the indemnitor unless a written claim for indemnification in respect
thereof has been made. The amount of any Contingent Liability shall be deemed to
be an amount equal to the stated or determinable amount of the primary
obligation in respect of which such Contingent Liability is made or, if not
stated or determinable, the reasonably anticipated maximum liability in respect
thereof (assuming the Person obligated on such Contingent Liability is required
to perform thereunder) as determined by Lender.

COST OF FUNDS ADVANCE means a Revolving Credit Loan bearing interest at the rate
determined under Section 2.3.2.

COST OF FUNDS RATE means the rate on any date designated by Lender as its cost
of funds rate for the period and amount of the applicable Cost of Funds Advance.

CREDIT AGREEMENT as defined in the Preamble.

CURRENT LIABILITIES as defined in Section 4.15.5(v).

DEFAULT as defined in Section 7.1.

DEFAULT RATE as defined in Section 2.5.

DOLLARS shall mean lawful money of the United States.

ERISA means the Employee Retirement Income Security Act of 1974, as amended from
time to time, including all regulations promulgated under such Act.

EVENT OF DEFAULT as defined in Section 7.1.

$15,000,000 LINE OF CREDIT as defined in Section 1.2.

FINANCIAL STATEMENTS means financial statements of Borrower prepared on a
consistent basis in accordance with GAAP and containing balance sheets,
statements of income and retained earnings and statements of cash flow.
Financial Statements for a fiscal year shall contain an audit report by
independent certified public accountants selected by Borrower and being one of
the so-called "Big Six" United States accounting firms or otherwise acceptable
to Lender. Financial Statements for a fiscal quarter shall be certified by the
chief financial officer of Borrower.

FIRST AMENDMENT as defined in Section 1.2.

FUNDED DEBT as defined in Section 4.15.5(vi).





                                      -3-
<PAGE>   40

GAAP means those generally accepted accounting principles set forth in
Statements of the Financial Accounting Standards Board and in Opinions of the
Accounting Principles Board of the American Institute of Certified Public
Accountants or which have other substantial authoritative support in the United
States and are applicable in the circumstances, as applied on a consistent
basis. As used in the preceding sentence "consistent basis" shall mean that the
accounting principles observed in the current period are comparable in all
material respects to those applied in the preceding period.

INITIAL LOAN PERIOD means the period commencing on the Closing Date to and
including the ninetieth (90th) day after the Closing Date.

INDEBTEDNESS as defined in Section 4.15.5(vii).

INTELLECTUAL PROPERTY means "Intellectual Property," as defined in Section
101(60) of the Bankruptcy Code, now or hereafter owned by Borrower or any of its
Subsidiaries, together with all of the following property now or hereafter owned
by Borrower or any of its Subsidiaries: all domestic and foreign patents and
patent applications; inventions, discoveries and improvements, whether or not
patentable; trademarks, trademark applications and registrations; service marks,
service mark applications and registrations; copyrights, copyright applications
and registrations; all licenses therefor; trade secrets and all other
proprietary information.

INVESTMENT COMPANY as defined in Section 3.17.

IRC means the Internal Revenue Code of 1986, as amended from time to time and
including all regulations promulgated thereunder.

LEGAL REQUIREMENTS means all applicable federal, state, county and local laws,
by-laws, rules, regulations, codes and ordinances, and the requirements of any
governmental agency or authority having or claiming jurisdiction with respect
thereto, including, but not limited to, those applicable to zoning, subdivision,
building, health, fire, safety, sanitation, the protection of the handicapped,
and environmental matters and shall also include all orders and directives of
any court, governmental agency or authority having or claiming jurisdiction with
respect thereto.

LENDER as defined in the Preamble.

LIBOR ADVANCE means a Revolving Credit Loan bearing interest at the rate
determined under Section 2.3.1.

LIBO RATE means with respect to each LIBOR Interest Period, the rate of
interest, expressed as an annual rate, equal to the simple average, rounded up
to the nearest 1/16 of 1%, of the rates shown on the display referred to as the
"LIBO page" (or any display substituted therefor) of the Reuters U.S. Domestic
Money Service transmitted through the Reuters monitor system as being the
respective rates at which deposits in Dollars would be offered by the principal
London offices of each of the banks named thereon to major banks in the London
interbank market at approximately 11:00 A.M. (London time) on the second London
Banking Day before the first 



                                      -4-
<PAGE>   41


day of such LIBOR Interest Period for a period substantially coextensive with
such LIBOR Interest Period.

LIBOR INTEREST PERIOD means a period of one (1), two (2), three (3), or six (6)
consecutive months, subject to availability, as selected, or deemed selected, by
the Borrower at least one (1) Business Day prior to a LIBOR Advance, or if a
LIBOR Advance is already outstanding, at least one (1) Business Day prior to the
end of the current LIBOR Interest Period. Each such LIBOR Interest Period shall
commence on the Business Day so selected, or deemed selected, by Borrower and
shall end on the numerically corresponding day in the first, second, third, or
sixth month thereafter, as applicable. PROVIDED, HOWEVER: (i) if there is no
such numerically corresponding day, such LIBOR Interest Period shall end on the
last Business Day of the applicable month, (ii) if the last day of such a LIBOR
Interest Period would otherwise occur on a day which is not a Business Day, such
LIBOR Interest Period shall be extended to the next succeeding Business Day; but
(iii) if such extension would otherwise cause such last day to occur in a new
calendar month, then such last day shall occur on the next preceding Business
Day. No LIBOR Interest Period may be selected which would end beyond the
Revolving Credit Termination Date.

LIENS means, with respect to any asset, any mortgage, lien, pledge, charge,
security interest, attachment, levy or encumbrance of any kind in respect of
such asset whether obtained by consent or by judicial process. For the purposes
of this Agreement, Borrower shall be deemed to own subject to a Lien any asset
which it has acquired or holds subject to the interest of a vendor or lessor
under any conditional sale agreement, capital lease or other title retention
agreement relating to such asset.

LOAN DOCUMENTS has the meaning given such term in Section 6.1.1.

LONDON BANKING DAY - any day on which dealings in deposits in Dollars are
transacted in the London interbank market.

MARKETABLE SECURITIES as defined in Section 4.15.5(viii).

MATERIAL ADVERSE EFFECT means the occurrence of any event or circumstance that
would make the breach of any of the financial covenants set forth in Section
4.15 probable in accordance with GAAP.

MATURITY DATE means the date specified as the maturity date for any Cost of
Funds Advance, which shall not be less than seven (7) days after the date that
such Cost of Funds Advance is made.

MINIMUM REVOLVING CREDIT COMMITMENT has the meaning given such term in Section
2.11.

MULTIEMPLOYER PLAN means a Plan which is a multiemployer plan as defined in
Section 3(37)(A) of ERISA or Section 414(f) of the IRC.




                                      -5-
<PAGE>   42

OBLIGATIONS means any and all Revolving Credit Loans, including any principal,
interest, charges, fees, costs and expenses (including any interest arising
after the filing of any bankruptcy petition and notwithstanding any law to the
contrary) and all other obligations, liabilities and indebtedness of the
Borrower of any kind, nature or description arising under this Agreement or the
Revolving Credit Note.

OPERATING INCOME as defined in Section 4.15.5(ix).

PBGC means the Pension Benefit Guaranty Corporation and its successors and
assigns.

PERSON means an individual, partnership, corporation, business trust, joint
stock company, trust, unincorporated association, joint venture, governmental
authority or other entity of whatever nature.

PLAN means any pension plan, as defined in Section 3(2) of ERISA and any welfare
plan, as defined in Section 3(1) of ERISA, which is sponsored, maintained or
contributed to by Borrower or any Commonly Controlled Entity, or in respect of
which Borrower or a Commonly Controlled Entity is an "employer" as defined in
Section 3(5) of ERISA.

PRIME RATE means the per annum rate of interest so designated from time to time
by Lender as its prime rate. The Prime Rate is a reference rate and does not
necessarily represent the lowest or best rate being charged to any customer.

REPORTABLE EVENT means any of the events set forth in section 4043(b) of ERISA.

REVOLVING CREDIT COMMITMENT PERIOD means the period from and including the
Borrowing Date to and including the Revolving Credit Termination Date.

REVOLVING CREDIT COMMITMENT means as of the Closing Date of the Agreement, the
Lender's commitment to make Revolving Credit Loans in the aggregate amount of
Two Hundred Fifteen Million Dollars ($215,000,000.00) as such amount may be
reduced pursuant to the terms of this Agreement.

REVOLVING CREDIT LOAN means any loan made pursuant to Section 2.1.

REVOLVING CREDIT NOTE means the promissory note of Borrower made to evidence the
Revolving Credit Loans, in the form of EXHIBIT A to the Agreement, as it may be
amended, supplemented or otherwise modified, from time to time.

REVOLVING CREDIT TERMINATION DATE means the earlier of (a) September 1, 1997,
and (b) the date the Revolving Credit Commitment is terminated upon or following
an Event of Default.

SECOND AMENDMENT as defined in Section 1.2.

STATEMENT as defined in Section 9.17.




                                      -6-
<PAGE>   43


SUBORDINATED DEBT as defined in Section 4.15.5(x).

SUBSIDIARY means with respect to any Person, any corporation, partnership, trust
or other organization, whether or not incorporated, the majority of the voting
stock or voting rights of which is owned or controlled, directly or indirectly,
by such Person.

TANGIBLE NET WORTH as defined in Section 4.15.5(xi).

TERM LOAN as defined in Section 1.1.

TERM LOAN AGREEMENT as defined in Section 1.1.

TITLE IV PLAN means any Plan that is covered by Title IV of ERISA.

TOTAL LONG TERM SENIOR LIABILITIES as defined in Section 4.15.5(xii).

TREASURY RATE means as of the date of any calculation or determination, the
latest published rate for United States Treasury Notes or Bills (but the rate on
Bills issued on a discounted basis shall be converted to a bond equivalent) as
published weekly in the Federal Reserve Statistical Release H.15(519) of
Selected Interest Rates in an amount which approximates (as determined by
Lender) the amount (i) comparable to the portion of the Loan to which the
Treasury Rate applies for the Designated Term, or (ii) in the case of a
prepayment, the amount prepaid and with a maturity closest to the original
maturity of the installment which is prepaid in whole or in part.

UCC means the Uniform Commercial Code in effect in the Commonwealth of
Massachusetts.

YIELD MAINTENANCE FEE as defined in Section 2.13.





                                      -7-
<PAGE>   44

                         SCHEDULE B TO CREDIT AGREEMENT
                         ------------------------------

                           AUTHORIZED REPRESENTATIVES
                           --------------------------

      Any one or more of:

            (i)   President (Henri A. Termeer)

            (ii)  Senior Vice President, Finance (David J. McLachlan)

            (iii) Vice President and Treasurer (Evan M. Lebson)

            Also:  for the purpose of issuing corporate certificates of vote
and attesting signatures and authority, Peter Wirth, Clerk and Mark Hofer,
Assistant Clerk.





                                      -1-
<PAGE>   45
SCHEDULE 4.9                 CONTINGENT LIABILITIES


BANK GUARANTEE
Guarantee by Genzyme Corporation of bank financing                   $10.75M
to Genzyme Transgenics Corporation
($8.45M Line of Credit and $2.3M Term Loan)


CONVERTIBLE DEBT
Credit Line to Genzyme Transgenics; convertible into                 $ 9.85M
GTC stock under certain conditions; $150,000 of the $10.0M
was converted on March 31, 1996


<PAGE>   46
SCHEDUEL 4.11                           LIENS


MORTGAGE NOTE                                                    SECURITY
Balance due on 5/31/96 of$3.3M                             Land and Buildings at
Mortgage held by Mellon Bank                               2000 Vivigen Way,
                                                           Sane Fe, New Mexico


MORTGAGE NOTE                                                    SECURITY
Balance due on 5/31/96 of $0.7M                            Land and Buildings at
Mortgage held by Norwest Bank                              2000 Vivigen Way,
                                                           Sane Fe, New Mexico



<PAGE>   47

                          EXHIBIT A TO CREDIT AGREEMENT
                          -----------------------------

                              REVOLVING CREDIT NOTE
                              ---------------------


$215,000,000.00                                          Boston, Massachusetts
                                                                 June 28, 1996

FOR VALUE RECEIVED, the undersigned, Genzyme Corporation, a Massachusetts
corporation, with a principal place of business at Building 1400, One Kendall
Square, Cambridge, Massachusetts 02139 (the "Maker"), hereby promises to pay to
the order of Fleet National Bank, a national banking association, having an
address at 75 State Street, Boston, Massachusetts 02109 (the "Lender"), the sum
of TWO HUNDRED FIFTEEN MILLION AND 00/100 DOLLARS ($215,000,000.00), or so much
as may have been advanced to the Maker, as provided under that certain Credit
Agreement dated as of June 28, 1996, as the same may be amended from time to
time (the "Credit Agreement"), together with interest on the unpaid principal
amount from time to time outstanding at the times, for the interest periods and
at the rates set forth in the Credit Agreement.

This Note evidences borrowings under the Credit Agreement and is entitled to all
benefits of the provisions of the Credit Agreement. All capitalized terms not
specifically defined herein shall have the same meanings as in the Credit
Agreement. The principal of this Note is subject to prepayment in the manner and
to the extent provided in the Agreement.

Maker also agrees to pay certain costs and expenses, including, without
limitation, reasonable attorneys' fees and expenses incurred, or which may be
incurred, by the holder in connection with the negotiation, documentation,
administration, and enforcement of this Note and the Credit Agreement.

If an Event of Default shall occur, the entire unpaid balance of principal,
accrued interest, and any and all other fees and charges may become, or may be
declared, immediately due and payable in the manner and with the effect provided
in the Credit Agreement.

The Maker and all guarantors and endorsers hereby waive presentment, demand,
notice, protest, and all other demands and notices in connection with the
delivery, acceptance, performance and enforcement of this Note, and assent to
extensions of the time of payment or forbearance or other indulgence without
notice.

Executed under seal as of the 28th day of June, 1996.

ATTEST:                             GENZYME CORPORATION


                                    By: 
- ------------------------------         -----------------------------------
Clerk or Assistant Clerk               David J. McLachlan
                                       Senior Vice President, Finance
[SEAL]



                                      -1-
<PAGE>   48

                          EXHIBIT B TO CREDIT AGREEMENT
                          -----------------------------
    
                         FORM OF COMPLIANCE CERTIFICATE
                         ------------------------------

CREDIT AGREEMENT BY AND BETWEEN GENZYME CORPORATION
AND FLEET BANK OF MASSACHUSETTS, N.A.


                             COMPLIANCE CERTIFICATE
                             ----------------------
 
                         
      This Compliance Certificate is provided pursuant to Section [_______]
[________] [________] of that certain Credit Agreement (the "Agreement") dated
as of June 28, 1996, between Genzyme Corporation ("Borrower") and Fleet National
Bank of Massachusetts, N.A. ("Lender"). The capitalized terms used herein shall
have the meanings ascribed to such terms in the Agreement. The undersigned
hereby certifies as follows as of this date:

      1. The representations and warranties made by Borrower in the Agreement
and in each certificate, document or financial or other statement furnished
under or in connection therewith are true and accurate in all material respects.

      2. The financial information and calculations shown on the attached
Schedule A are true and accurate as of the date hereof and the Borrower is in
compliance with the financial covenants set forth in Section 4.15 of the Loan
Agreement.

      3. No Default or Event of Default under the Agreement has occurred.

      IN WITNESS WHEREOF, this Certificate has been duly executed and delivered
as a sealed instrument at Boston, Massachusetts on this ____ day of ________,
199_.

                                     GENZYME CORPORATION


                                     By:
                                        ------------------------------------   
                                     Name:
                                          ----------------------------------   
                                     Title:
                                          ----------------------------------   




<PAGE>   49

                                   SCHEDULE A
                                   ----------
                                  TO EXHIBIT A
                                  ------------
 

Section 4.15.1  Minimum Cash Coverage
- --------------  ---------------------

cash -- $__________

Cash Equivalents -- $___________

Marketable Securities -- $____________

Funded Debt -- $____________

Actual Ratio -- ____________

Minimum Ratio -- _____________

NOTE:  For the above, all cash, Cash Equivalents  and Marketable Securities
must be owned by Borrower and its wholly owned Subsidiaries.

Section 4.15.2  Minimum Liquidity
- --------------  -----------------

cash -- $_________

Accounts Receivable -- $___________

Current Liabilities -- $___________

Total Long Term Senior Liabilities -- $___________

Actual Ratio -- ___________

Minimum Ratio: -- __________

NOTE:  The Minimum Liquidity covenant is computed with reference to cash,
Cash Equivalents and Accounts Receivable of Borrower and its Consolidated
Subsidiaries.

Section 4.15.3  Minimum Tangible Net Worth
- --------------  --------------------------

Tangible Net Worth -- $___________

Minimum Tangible Net Worth -- $____________

Section 4.15.4  Profitability
- --------------  -------------



                                      -1-
<PAGE>   50


Actual Quarterly Operating Incomes for the quarter ending _____________

Minimum Quarterly Operating Incomes Required -- $10,000,000

Actual Fiscal Year Operating Incomes for the Year Ending 12/31/__ --$__________

Minimum Fiscal Year Operating Incomes Required -- $50,000,000









                                      -2-
<PAGE>   51
                     THIRD AMENDMENT TO TERM LOAN AGREEMENT

            THIRD AMENDMENT TO TERM LOAN AGREEMENT ("Third Amendment") made and
entered into as of the 28th day of June, 1996, by and among GENZYME CORPORATION,
a Massachusetts corporation, having a principal place of business at Building
1400, One Kendall Square, Cambridge, Massachusetts 02139 ("Borrower") and FLEET
NATIONAL BANK, a national banking association, having an address at 75 State
Street, Boston, Massachusetts 02109 ("Lender").

                                  W I T N E S S E T H:

      1.      BACKGROUND
 
      1.1. ORIGINAL AGREEMENT. Borrower and Fleet Bank of Massachusetts, N.A., a
predecessor to Lender ("Fleet-MA"), entered into a Term Loan Agreement dated as
of June 13, 1994 (the "Original Agreement") and a First Amendment to Term Loan
Agreement dated as of August 29, 1994 (the "First Amendment") pursuant to which
Lender furnished to Borrower, among other things, a $15,000,000 revolving line
of credit (the "Original Line of Credit"). The Original Line or Credit was
extended pursuant to a Second Amendment to Term Loan Agreement dated as of
August 31, 1995 (the "Second Amendment").

      1.2. REPLACEMENT LINE OF CREDIT. Borrower has requested that Lender
provide a $215,000,000 line of credit to Borrower and Lender has agreed to do
so, pursuant to a Credit Agreement of even date (the "Credit Agreement"), which
line of credit will supersede and replace the Original Line of Credit.

      1.3 FINANCIAL COVENANTS. In connection with the extension of the
$215,000,000 line of credit pursuant to the Credit Agreement, Lender and
Borrower have agreed to certain modifications set forth herein to the financial
covenants found in Section 9.21 of the Original Agreement.

      1.4 DEFINED TERMS. Capitalized terms used in this Third Amendment have
the meanings given such terms in the Original Agreement, as amended hereby, and
except as provided otherwise herein.

      2.    TERMINATION OF REVOLVING LINE OF CREDIT. Section 2A of the Original
Agreement and the definitions that were added to the Schedule A to the Original
Agreement pursuant to the First Amendment are deleted in their entirety.

      3. AMENDMENTS TO SECTION 9.21 - CERTAIN BORROWER FINANCIAL COVENANTS.
Section 9.21 of the Original Agreement and all defined terms in Schedule A
relating thereto are deleted in their entirety and replaced with the following:

      "9.21 CERTAIN BORROWER FINANCIAL COVENANTS.



<PAGE>   52



      9.21.1 MINIMUM CASH COVERAGE OF FUNDED DEBT. Borrower and its wholly-owned
Subsidiaries shall maintain a ratio of (A) unrestricted and unpledged cash, Cash
Equivalents and Marketable Securities, to (B) Funded Debt, of (c) not less than
the ratio set forth below as determined on the last day of the following fiscal
quarters:

                             Period                       Ratio
                             ------                       -----

              Fiscal Quarter Ended June 30, 1996         1.0:1.0

              Fiscal Quarter Ended September 30, 1996    .95:1.0

              Thereafter at each Fiscal Quarter End      1.0 to 1.0

provided, however, that upon the reduction by Borrower of the Revolving Credit
Commitment to the Minimum Revolving Credit Commitment under Section 2.11 of the
Credit Agreement, the foregoing ratio shall be 1.1 to 1.0, as determined on the
last day of each fiscal quarter of Borrower thereafter.

      9.21.2 MINIMUM LIQUIDITY. Borrower and its Consolidated Subsidiaries
shall maintain a ratio of (A) cash and Cash Equivalents, plus Marketable
Securities, plus Accounts Receivable, to (B) Current Liabilities plus Total Long
Term Senior Liabilities, of (c) .85 to 1.0 as determined on the last day of each
fiscal quarter of Borrower; provided, however that upon the reduction by
Borrower of the Revolving Credit Commitment to the Minimum Revolving Credit
Commitment under Section 2.11 of the Credit Agreement, the foregoing ratio shall
be 1.5 to 1.0, as determined on the last day of each fiscal quarter of Borrower
thereafter.

      9.21.3 MINIMUM TANGIBLE NET WORTH. Borrower and its Consolidated
Subsidiaries shall maintain a Tangible Net Worth of not less than
$350,000,000.00, as determined on the last day of each fiscal quarter of
Borrower.

      9.21.4 PROFITABILITY. Borrower and its Consolidated Subsidiaries shall
have minimum quarterly Operating Income of $10,000,000.00 and minimum fiscal
year Operating Income of $50,000,000.00.

      9.21.5 CERTAIN DEFINITIONS.

      (i) "ACCOUNTS RECEIVABLE" shall mean, on any date the net amount of
accounts receivable of Borrower and its Consolidated Subsidiaries, excluding any
such accounts which are more than 120 days old, after deducting all returns,
discounts and allowances thereon and reserves relating thereto, determined in
accordance with GAAP.

      (ii) "CASH EQUIVALENTS"  shall mean any interest bearing investment of
Borrower and (x) its wholly-owned Subsidiaries in respect of the Minimum Cash
covenant set forth in Section 9.21.1, or (y) its Consolidated Subsidiaries for
all other purposes, which meets the definition of a "cash equivalent" under GAAP
(i.e. purchased with a remaining maturity of 90 days or less).



                                    -2-


<PAGE>   53


Such investments shall be at least investment grade (A1/P1 for commercial paper,
BBB or better for bonds and similar investments).

      (iii) "CONSOLIDATED NET INCOME" shall mean, for any period, the net income
(or deficit) of Borrower and its Consolidated subsidiaries determined in
accordance with GAAP on a Consolidated basis; provided, however, that
Consolidated Net Income shall not include: (a) all amounts included in computing
net income (or deficit) in respect of the write-up of any asset (other than
marketable securities) after December 31, 1995; and (b) extraordinary and
nonrecurring gains or losses as determined in accordance with GAAP.

      (iv) "CONSOLIDATED NET WORTH" - shall mean, at any date, the shareholder's
equity of the Borrower and its Consolidated Subsidiaries determined in
accordance with GAAP on a Consolidated basis;

      (v) "CURRENT LIABILITIES" - shall mean any liability that in accordance
with GAAP would be classified as such.

      (vi) "FUNDED DEBT" - shall mean the outstanding balance of all
Indebtedness in respect of borrowed money, letters of credit and trade
acceptances (excluding however Subordinated Debt).

      (vii) "INDEBTEDNESS" - shall mean with respect to Borrower and its
Consolidated Subsidiaries, any item that would properly be included as a
liability on the liability side of a balance sheet as of any date as of which
Indebtedness is to be determined and includes (but is not limited to) (a) all
obligations for borrowed money, (b) all obligations evidenced by bonds,
debentures, notes or other similar instruments, (c) all obligations to pay the
deferred purchase price of property or services, (d) all Capital Lease
Obligations and (e) all obligations in respect of advances under letters of
credit issued for such Person's account and in respect of acceptances of drafts
drawn by such Person.

      (viii) "MARKETABLE SECURITIES" shall mean any interest bearing debt
obligations owned by (x) Borrower and its wholly-owned Subsidiaries for the
purpose of Section 9.21.1, and (y) and for all other purposes by Borrower and
its Consolidated Subsidiaries (excluding directors' qualifying shares) of
Borrower (without duplication of items included as Cash Equivalents) which meet
the definition of marketable securities under GAAP. Such amounts shall exclude
common or preferred stock. Such securities shall include obligations issued by
the U.S. Treasury and other agencies of the U.S. government, corporate bonds,
bank notes, mortgage and asset backed securities, finance company securities,
and auction rate preferred stocks. Such securities shall be rated investment
grade (BBB or better for bonds or similar securities, A1/P1 for commercial
paper and notes) and which are otherwise reasonably liquid investments.

      (ix) "OPERATING INCOME" shall mean the Consolidated Net Income of Borrower
and its Consolidated Subsidiaries without deduction for taxes, interest expense,
interest income, income attributable to minority interests held by Borrower and
the before-tax effects of non-operating

                                         -3-




<PAGE>   54



non-cash items including, but not limited to, write-off of acquired technology
or acquired research and development, which, in accordance with GAAP, may be
charged to income.

      (x) "SUBORDINATED DEBT" shall mean Indebtedness of Borrower and its
Subsidiaries that by its terms is fully subordinated to the payment and
enforcement of the Loans in a manner reasonably satisfactory to Lender.

      (xi) "TANGIBLE NET WORTH" shall mean the Consolidated Net Worth of
Borrower less all intangible assets of the Borrower and its Consolidated
Subsidiaries determined in accordance with GAAP on a Consolidated basis plus all
indebtedness of the Borrower that is subordinated to the full repayment of the
Obligations in a manner satisfactory to Lender.

      (xii) "TOTAL LONG TERM SENIOR LIABILITIES" shall mean all Indebtedness of
the Borrower and its Consolidated Subsidiaries on a Consolidated basis,
excluding Current Liabilities and Indebtedness which is Subordinated Debt."

      All cross-references to the subsections of 9.21 or the defined terms in
Section 9.21.5 of the Original Agreement are amended to reflect the foregoing
changes to Section 9.21 and to the subsections included therein and to terms
defined above.

      3.1. REPRESENTATIONS AND WARRANTIES. In order to induce the Lender to
enter into this Third Amendment, Borrower makes the following representations
and warranties, all of which shall survive the execution and delivery of this
Third Amendment:

             (a) The Borrower has full corporate power and authority to execute
and deliver this Third Amendment, and the other agreements, documents and
instruments executed in connection herewith or contemplated hereby, and to
perform its obligations hereunder and thereunder and under the Original
Agreement as amended hereby. This Third Amendment and each of the other
agreements, documents and instruments executed by the Borrower in connection
herewith or contemplated hereby, has been duly authorized, executed and
delivered by the Borrower, and does not contravene any law, rule or regulation
applicable to the Borrower or any of the terms of its Articles of Organization
or by-laws or any other material indenture, agreement or undertaking to which
the Borrower is a party. The obligations of the Borrower hereunder, and under
the other agreements, documents and instruments executed in connection herewith
or contemplated hereby, and under the Original Agreement as amended hereby
constitute the legal, valid and binding obligations of the Borrower enforceable
against the Borrower in accordance with their respective terms.

            (b) On the date hereof each of the representations and warranties in
the Original Agreement are true, accurate and complete in all material respects.

            (c) Upon the execution and delivery of this Third Amendment and the
other agreements, documents and instruments executed in connection herewith or
contemplated hereby, and the satisfaction of each of the conditions precedent
set forth in Section 4 of this Third Amendment, no Default or Event of Default
shall exist and be continuing.

                                    -4-




<PAGE>   55



      4. CONDITIONS PRECEDENT. The agreements contained herein and the
amendments contemplated hereby shall become effective on the date (the
"Effective Date") when Borrower shall have executed this Third Amendment and
shall have delivered the same to the Lender and when each of the following
conditions shall have been fulfilled:

            (a) EXECUTION OF DOCUMENTS. ETC. Each of this Third Amendment and
any other agreements, documents and instruments to be executed and/or delivered
in connection herewith and therewith (collectively the "Transaction Documents")
shall have been duly and properly authorized, executed and delivered by the
respective party or parties thereto and shall be in full force and effect on and
as of the Effective Date of this Third Amendment.

            (b) PROCEEDINGS: RECEIPT OF DOCUMENTS. All requisite corporate
action and proceedings in connection with the execution and delivery of this
Third Amendment and the other Transaction Documents shall be satisfactory in
form and substance to the Lender and its counsel, and the Lender and its counsel
shall have received all information and copies of all documents, including
without limitation, records of requisite corporate action and proceedings which
the Lender or its counsel may have requested in connection therewith, such
documents where requested by the Lender or its counsel to be certified by
appropriate persons or governmental authorities.

            (c) MATERIAL LITIGATION. There shall be no pending or, to the best
knowledge of the Borrower, threatened litigation with respect to the Borrower
before any court, arbitrator or governmental or administrative body or agency
which challenges or relates to (i) the transactions contemplated hereby or (ii)
the Loan Documents.

            (d) NO MATERIAL ADVERSE CHANGE. In the judgment of the Lender (a) no
event or change in circumstances shall have occurred which has or would have a
Material Adverse Effect on the Borrower from that reflected in the financial
statements of the Borrower most recently furnished to Lender and (b) no Default
or Event of Default shall have occurred and be continuing.

            (e) REPLACEMENT LINE OF CREDIt. All conditions precedent to the 
closing of the $215,000,000 line of credit under the Credit Agreement shall have
been satisfied or waived by the Lender.

      5. REAFFIRMATION AND RATIFICATION OF EXISTING AGREEMENTS. ETC. The
Borrower: (i) reaffirms and ratifies all the obligations to the Lender, in
respect of the Original Agreement and the other Loan Documents as amended
hereby, (ii) certifies that there are no defenses, offsets or counterclaims
thereto as of the date hereof to said obligations, (iii) expressly acknowledges
its continuing liability pursuant thereto, (iv) agrees that each of the Original
Agreement and the other Loan Documents, as amended hereby, shall remain in full
force and effect, enforceable against the Borrower in accordance with its terms,
and (v) hereby confirms that such obligations shall survive and continue in
accordance with said terms as said documents are amended by this

                                    -5-
                                                           




<PAGE>   56



Third Amendment. Further, the Borrower understands that the Lender is relying on
these representations as a basis for entering into this Third Amendment.

     6.    MISCELLANEOUS.

            (a) This Third Amendment may be executed on separate counterparts by
the parties hereto, each of which when so executed and delivered shall be an
original, but all of which shall constitute one and the same agreement.

            (b) This Third Amendment and the rights and obligations of the
parties hereunder shall be construed in accordance with and be governed by the
laws of the Commonwealth of Massachusetts (without giving effect to the conflict
of law principles thereof).

            (c) The headings of the several sections of this Third Amendment are
inserted for convenience only and shall not in any way affect the meaning or
construction of any provision of this Third Amendment.

            (d) This Third Amendment effectively amends the Original Agreement
in accordance with the terms hereof and supersedes and replaces the First
Amendment and the Second Amendment. This Third Amendment, together with the
other Transaction Documents, and the Loan Documents, as modified by this Third
Amendment, embodies the entire agreement and understanding among the parties
relating to the subject matter hereof and supersedes all prior proposals,
negotiation, agreements and understandings relating to such subject matter.

            (e) BORROWER AND LENDER MUTUALLY HEREBY KNOWINGLY, VOLUNTARILY AND
INTENTIONALLY WAIVE THE RIGHT TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION
BASED HEREON, ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS THIRD AMENDMENT
OR ANY OTHER LOAN DOCUMENTS CONTEMPLATED TO BE EXECUTED IN CONNECTION HEREWITH,
OR ANY COURSE OF CONDUCT, COURSE OF DEALINGS, STATEMENTS (WHETHER VERBAL OR
WRITTEN) OR ACTIONS OF ANY PARTY. THIS WAIVER CONSTITUTES A MATERIAL INDUCEMENT
FOR LENDER TO ACCEPT THIS THIRD AMENDMENT AND MAKE REVOLVING CREDIT LOANS.

            (f) Borrower shall pay on demand the costs and expenses, including,
without limitation, reasonable attorneys' fees and expenses incurred, or which
may be incurred by Lender in connection with the negotiation, documentation,
administration and enforcement of this Third Amendment.

                                   -6-                 




<PAGE>   57


     IN WITNESS WHEREOF, this Third Amendment has been duly executed and 
delivered as a sealed instrument at Boston, Massachusetts as of the 28th day of
June, 1996.


                                        GENZYME CORPORATION

                                        By: /s/ David J. McLachlan
                                           ----------------------------------
                                           David J. McLachlan
                                           Senior Vice President, Finance


                                        FLEET NATIONAL BANK

                                        By: /s/ Catherine M. Bruton
                                           ---------------------------------  
                                           Catherine M. Bruton, Vice President



<PAGE>   58

                                  June 28, 1996

Fleet National Bank
75 State Street
Boston, MA 02109

Ladies and Gentlemen:

      Reference is made to the Credit Agreement of even date between the
undersigned and Fleet National Bank. All capitalized terms not otherwise defined
in this letter shall have the definitions found in the Credit Agreement.

      In addition to the fees payable to the Lender pursuant to Section 2.9 of
the Credit Agreement, Borrower agrees to pay to Lender the following additional
compensation:

      1. SECOND STRUCTURING FEE. The Borrower shall pay to the Lender a second
structuring fee equal to twenty (20) basis points (.20%) on the amount by which
the Revolving Credit Commitment on the ninety-first (91st) day after the
Closing Date exceeds the Minimum Revolving Credit Commitment.

      2. ADMINISTRATIVE FEE. In the event that Lender sells participation
interests or assigmnents in the Revolving Credit Loans and Revolving Credit
commitment after the Initial Loan Period, the Borrower shall pay to the Lender
an annual administration fee of $10,000 due and payable on the ninety-first 
(91st) day after the Closing Date and on each anniversary of the Closing Date 
while the Revolving Credit Commitment remains in effect or any Revolving 
Credit Loans are outstanding.

      This letter agreement is made subject to the terms and conditions of the
Credit Agreement, which are incorporated herein by reference and made a part
hereof.

      Executed as an instrument under seal on the 28th day of June, 1996.

                                       GENZYME CORPORATION

                                       By: /s/ David J. McLachlan
                                          -------------------------------
                                          David J. McLachlan
                                          Senior Vice President, Finance
Agreed:

FLEET NATIONAL BANK

By: /s/ Catherine M. Bruton
    -------------------------------------
    Catherine M. Bruton, Vice President








<PAGE>   1

                                                                    EXHIBIT 4.2

                              REVOLVING CREDIT NOTE
                              ---------------------


$215,000,000.00                                           Boston, Massachusetts
                                                          June 28, 1996

FOR VALUE RECEIVED, the undersigned, Genzyme Corporation, a Massachusetts
corporation, with a principal place of business at Building 1400, One Kendall
Square, Cambridge, Massachusetts 02139 (the "Maker"), hereby promises to pay to
the order of Fleet National Bank, a national banking association, having an
address at 75 State Street, Boston, Massachusetts 02109 (the "Lender"), the sum
of TWO HUNDRED FIFTEEN MILLION AND 00/100 DOLLARS ($215,000,000.00), or so much
as may have been advanced to the Maker, as provided under that certain Credit
Agreement dated as of June 28, 1996, as the same may be amended from time to
time (the "Credit Agreement"), together with interest on the unpaid principal
amount from time to time outstanding at the times, for the interest periods and
at the rates set forth in the Credit Agreement.

This Note evidences borrowings under the Credit Agreement and is entitled to all
benefits of the provisions of the Credit Agreement. All capitalized terms not
specifically defined herein shall have the same meanings as in the Credit
Agreement. The principal of this Note is subject to prepayment in the manner and
to the extent provided in the Agreement.

Maker also agrees to pay certain costs and expenses, including, without
limitation, reasonable attorneys' fees and expenses incurred, or which may be
incurred, by the holder in connection with the negotiation, documentation,
administration, and enforcement of this Note and the Credit Agreement.

If an Event of Default shall occur, the entire unpaid balance of principal,
accrued interest, and any and all other fees and charges may become, or may be
declared, immediately due and payable in the manner and with the effect provided
in the Credit Agreement.

The Maker and all guarantors and endorsers hereby waive presentment, demand,
notice, protest, and all other demands and notices in connection with the
delivery, acceptance, performance and enforcement of this Note, and assent to
extensions of the time of payment or forbearance or other indulgence without
notice.

Executed under seal as of the 28th day of June, 1996.

ATTEST:                                GENZYME CORPORATION


                                       By:
- -----------------------------             -----------------------------------
Clerk or Assistant Clerk                  David J. McLachlan
                                          Senior Vice President, Finance
[SEAL]





<PAGE>   1
                                                                   Exhibit 23.2

                             ARTHUR ANDERSEN LLP




                  CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS




As independent public accountants, we hereby consent to the use of our reports
and to all references to our firm included in or made a part of this
Registration Statement.




                                                /s/ ARTHUR ANDERSEN LLP
                                                -----------------------------
                                                ARTHUR ANDERSEN LLP



Boston, Massachusetts
July 15, 1996






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