GENZYME CORP
SC 13E3/A, 1996-10-29
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
 
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                            ------------------------
 
                                 SCHEDULE 13E-3
 
                        RULE 13E-3 TRANSACTION STATEMENT
       (PURSUANT TO SECTION 13(E) OF THE SECURITIES EXCHANGE ACT OF 1934)

                              (AMENDMENT NO. 2 )
                 NEOZYME II CORPORATION AND GENZYME CORPORATION
- --------------------------------------------------------------------------------
                                (NAME OF ISSUER)

  NEOZYME II CORPORATION, GENZYME CORPORATION AND NEOZYME II ACQUISITION CORP.
- --------------------------------------------------------------------------------
                      (NAME OF PERSON(S) FILING STATEMENT)

 UNITS, EACH CONSISTING OF ONE SHARE OF CALLABLE COMMON STOCK, $1.00 PAR VALUE,
  OF NEOZYME II CORPORATION AND ONE CALLABLE WARRANT TO PURCHASE TWO SHARES OF
 GENERAL DIVISION COMMON STOCK, $.01 PAR VALUE, AND 0.135 OF A SHARE OF TISSUE
      REPAIR DIVISION COMMON STOCK, $.01 PAR VALUE, OF GENZYME CORPORATION
- --------------------------------------------------------------------------------
                         (TITLE OF CLASS OF SECURITIES)
 
                                  G6420H146
- --------------------------------------------------------------------------------
                     (CUSIP NUMBER OF CLASS OF SECURITIES)
 
<TABLE>
  <S>                                   <C>                               <C>
       PETER WIRTH, ESQ.                STEVEN D. SINGER, ESQ.            MAUREEN P. MANNING, ESQ.
  EXECUTIVE VICE PRESIDENT AND              HALE AND DORR                    PALMER & DODGE LLP
      CHIEF LEGAL COUNSEL                  60 STATE STREET                   ONE BEACON STREET
      GENZYME CORPORATION                  BOSTON, MA 02109                   BOSTON, MA 02108
       ONE KENDALL SQUARE                   (617) 526-6000                     (617) 573-0100
      CAMBRIDGE, MA 02139
         (617) 252-7500
</TABLE>
 
- --------------------------------------------------------------------------------
  (NAME, ADDRESS AND TELEPHONE NUMBER OF PERSON AUTHORIZED TO RECEIVE NOTICES
          AND COMMUNICATIONS ON BEHALF OF PERSON(S) FILING STATEMENT)
 
    This statement filed in connection with (check the appropriate box):
 
    a. / / The filing of solicitation materials or an information statement
subject to Regulation 14A, Regulation 14C, or Rule 13e-3(c) under the Securities
Exchange Act of 1934.
 
    b. / / The filing of a registration statement under the Securities Act of
1933.
 
    c. /X/ A tender offer.
 
    d. / / None of the above.
 
    Check the following box if the soliciting materials or information statement
referred to in checking box (a) are preliminary copies. / /
 

                           CALCULATION OF FILING FEE
 
<TABLE>
<S>                                                  <C>
- ------------------------------------------------------------------------------------------------------
Transaction Valuation1: $108,675,000                 Amount of Filing Fee: $21,735
- ------------------------------------------------------------------------------------------------------
</TABLE>
 
    /X/  Check box if any part of the fee is offset as provided by Rule
         0-11(a)(2) and identify the filing with which the offsetting fee was
         previously paid. Identify the previous filing by registration statement
         number, or the form or schedule and the date of its filing.
 
<TABLE>
<S>                                          <C>              <C>
Amount previously paid: $21,735              Filing party:    Neozyme II Acquisition Corp. and Genzyme
                                                              Corporation
Form or registration no.: Schedule 14D-1     Date filed:      September 27, 1996
</TABLE>
<PAGE>   2
 
        This Amendment No. 2 to Rule 13e-3 Transaction Statement on Schedule
13E-3 ("Amendment") relates to the offer by Neozyme II Acquisition Corp. (the
"Purchaser"), a British Virgin Islands ("BVI") international business company
and a wholly-owned subsidiary of Genzyme Corporation ("Genzyme"), a
Massachusetts corporation, to purchase all of the outstanding units ("the
Units"), each consisting of one share of Callable Common Stock, par value $1.00
per share, of Neozyme II Corporation (the "Company"), a BVI international
business company, and one Callable Warrant to purchase two shares of General
Division common stock, par value $.01 per share, and 0.135 share of Tissue
Repair Division common stock, par value $.01 per share, of Genzyme at a purchase
price of $45.00 per Unit, net to the seller in cash, without interest thereon,
upon the terms and subject to the conditions set forth in the Offer to Purchase
dated September 27, 1996 (the "Offer to Purchase") and in the related Letter of
Transmittal (the "Letter of Transmittal," which, together with the Offer to
Purchase, as each may be amended or supplemented, constitute the "Offer"). The
Offer to Purchase and Letter of Transmittal were filed as Exhibits (d)(1) and
(d)(2), respectively, to the Rule 13e-3 Transaction Statement on Schedule 13E-3
originally filed by the Company, Genzyme and the Purchaser on September 27,
1996. 
 


ITEM 10.  INTEREST IN SECURITIES OF THE ISSUER.

     The response to Item 10 is hereby amended by adding the following:

     The Offer expired at 5:00 p.m., New York City time, on Monday, October 28,
1996. The Purchaser accepted for payment all of the 2,385,561 Units
(including 673,153 Units subject to guarantees of delivery) that were
validly tendered and not properly withdrawn pursuant to the Offer. The number
of Units accepted for payment by the Purchaser pursuant to the Offer equals
approximately 98.8% of the outstanding Units.


        
 
                                        2
<PAGE>   3
 
 
ITEM 17.  MATERIAL TO BE FILED AS EXHIBITS.
 
<TABLE>
<S>     <C>  <C>
(a)     --   Not applicable.

(b)(1)  --   Report of Robertson, Stephens & Company LLC.* 

(b)(2)  --   Opinion of Robertson, Stephens & Company LLC. Set forth in Annex II to the Offer
             to Purchase dated September 27, 1996 filed as Exhibit (a)(1) to the Schedule 14D-1
             filed by Genzyme Corporation and Neozyme II Acquisition Corp. on September 27, 
             1996 and incorporated herein by reference.

(b)(3)  --   Report of Hambrecht and Quist LLC.*

(b)(4)  --   Opinion of Hambrecht and Quist LLC.*

(c)(1)  --   Purchase Agreement dated as of September 20, 1996 by and among Genzyme
             Corporation, Neozyme II Acquisition Corp. and Neozyme II Corporation. Filed as
             Exhibit A to Amendment No. 2 to the Schedule 13D filed by Genzyme Corporation on
             September 24, 1996 and incorporated herein by reference.

(c)(2)  --   Technology License Agreement dated April 28, 1992 between Genzyme Corporation and
             Neozyme II Corporation. Filed as Exhibit 28.7 to the Genzyme Corporation Quarterly
             Report on Form 10-Q for the quarter ended March 31, 1992 and incorporated herein
             by reference.

(c)(3)  --   Research and Development Agreement dated as of April 28, 1992 between Genzyme
             Corporation and Neozyme II Corporation. Filed as Exhibit 28.8 to the Genzyme
             Corporation Quarterly Report on Form 10-Q for the quarter ended March 31, 1992 and
             incorporated herein by reference.

(c)(4)  --   Purchase Option Agreement dated April 28, 1992 between Genzyme Corporation and
             certain other parties named therein. Filed as Exhibit 28.9 to the Genzyme
             Corporation Quarterly Report on Form 10-Q for the quarter ended March 31, 1992 and
             incorporated herein by reference.

(c)(5)  --   Administrative Agreement dated April 28, 1992 between Genzyme Corporation and
             Neozyme II Corporation. Filed as Exhibit 28.10 to the Genzyme Corporation
             Quarterly Report on Form 10-Q for the quarter ended March 31, 1992 and
             incorporated herein by reference.
</TABLE>
 
                                        3
<PAGE>   4
 
<TABLE>
<S>     <C>  <C>
(c)(6)  --   Series 1992 Note of Neozyme II Corporation dated April 28, 1992. Filed as Exhibit
             28.11 to the Genzyme Corporation Quarterly Report on Form 10-Q for the quarter
             ended March 31, 1992 and incorporated herein by reference.

(c)(7)  --   Services Agreement dated April 28, 1992 between Genzyme Corporation and Neozyme II
             Corporation. Filed as Exhibit 10.5 to the Genzyme Corporation Annual Report on
             Form 10-K for the year ended December 31, 1993 and incorporated herein by
             reference.

(c)(8)  --   Amendment No. 1 dated as of August 11, 1993 to Technology License Agreement and
             Research and Development Agreement between Neozyme II Corporation and Genzyme
             Corporation. Filed as Exhibit 10.42 to the Genzyme Corporation Annual Report on
             Form 10-K for the year ended December 31, 1993 and incorporated herein by
             reference.

(c)(9)  --   License and Development Agreement dated as of August 11, 1993 between Genzyme
             Corporation and Univax Biologics, Inc. Filed as Exhibit 10.19 to the Form 10-Q of
             Univax Biologics, Inc. for the quarter ended September 30, 1993 (File No. 0-19748)
             and incorporated herein by reference. Confidential treatment has been granted for
             the deleted portions of this Exhibit.

(d)(1)  --   Offer to Purchase dated September 27, 1996. Filed as Exhibit (a)(1) to the
             Schedule 14D-1 filed by Genzyme Corporation and Neozyme II Acquisition Corp.
             on September 27, 1996 and incorporated herein by reference.

(d)(2)  --   Letter of Transmittal. Filed as Exhibit (a)(2) to the Schedule 14D-1 filed by
             Genzyme Corporation and Neozyme II Acquisition Corp. on September 27, 1996 
             and incorporated herein by reference.

(d)(3)  --   Notice of Guaranteed Delivery. Filed as Exhibit (a)(3) to the Schedule 14D-1 filed
             by Genzyme Corporation and Neozyme II Acquisition Corp. on September 27, 1996 
             and incorporated herein by reference.

(d)(4)  --   Letter from Robertson, Stephens & Company L.P. to Brokers, Dealers, Banks, Trust
             Companies and Other Nominees. Filed as Exhibit (a)(4) to the Schedule 14D-1 filed
             by Genzyme Corporation and Neozyme II Acquisition Corp. on September 27, 1996 
             and incorporated herein by reference.

(d)(5)  --   Letter to Clients for Use by Brokers, Dealers, Banks, Trust Companies and Other
             Nominees. Filed as Exhibit (a)(5) to the Schedule 14D-1 filed by Genzyme
             Corporation and Neozyme II Acquisition Corp. on September 27, 1996 and
             incorporated herein by reference.

(d)(6)  --   Guidelines for Certification of Taxpayer Identification Number on Substitute Form
             W-9. Filed as Exhibit (a)(6) to the Schedule 14D-1 filed by Genzyme Corporation
             and Neozyme II Acquisition Corp. on September 27, 1996 and incorporated
             herein by reference.

(d)(7)  --   Press Release of Genzyme Corporation dated September 6, 1996. Filed as Exhibit G
             to Amendment No. 1 to the Schedule 13D filed by Genzyme Corporation on September
             6, 1996 and incorporated herein by reference.

(d)(8)  --   Press Release of Genzyme Corporation dated September 23, 1996. Filed as Exhibit B
             to Amendment No. 2 to the Schedule 13D filed by Genzyme Corporation on September
             24, 1996 and incorporated herein by reference.

(d)(9)  --   Summary Advertisement dated September 27, 1996. Filed as Exhibit (a)(10) to the
             Schedule 14D-1 filed by Genzyme Corporation and Neozyme II Acquisition Corp.
             on September 27, 1996 and incorporated herein by reference.

(d)(10) --   Press Release of Genzyme Corporation dated September 27, 1996. Filed as Exhibit
             (a)(9) to the Schedule 14D-1 filed by Genzyme Corporation and Neozyme II
             Acquisiton Corp. on September 27, 1996 and incorporated herein by reference.

(d)(11) --   Press Release of Genzyme Corporation dated October 29, 1996. Filed as Exhibit 
             (a)(11) to Amendment No. 2 to Schedule 14D-1 filed by Genzyme Corporation and 
             Neozyme II Acquisition Corp. on October 29, 1996 and incorporated herein by 
             reference.

(e)     --   Description of appraisal rights and procedures. Set forth in Annex III to the
             Offer to Purchase filed as Exhibit (a)(1) to the Schedule 14D-1 filed by Genzyme
             Corporation and Neozyme II Acquisition Corp. on September 27, 1996 and
             incorporated herein by reference.
</TABLE>
 
                                        4
<PAGE>   5
 
<TABLE>
<S>     <C>  <C>
(f)     --   Not applicable.

(g)(1)  --   Audited financial statements (and related notes) for Neozyme II Corporation as of
             December 31, 1994 and 1995 and for the years ended December 31, 1993, 1994 and 1995, 
             and unaudited financial  statements (and related notes) for Neozyme II Corporation 
             as of June 30, 1996 and for the six months ended June 30, 1995 and 1996.*

(g)(2)  --   Audited financial statements (and related notes) for Genzyme Corporation, Genzyme
             General Division and Genzyme Tissue Repair Division as of December 31, 1994 and 
             1995 and for the years ended December 31, 1993, 1994 and 1995, and unaudited 
             financial statements (and related notes) for Genzyme Corporation, Genzyme General 
             Division and Genzyme Tissue Repair Division as of June 30, 1996 and for the six 
             months ended June 30, 1995 and 1996. Filed as Exhibit (g)(1) to the Schedule 13E-4 
             filed by Neozyme II Acquisition Corp. on September 27, 1996 and incorporated herein 
             by reference.

(g)(3)  --   Pro forma financial statements (and related notes) for Genzyme Corporation and
             Genzyme General Division as of June 30, 1996 and for the year ended December 31, 
             1995 and for the six months ended June 30, 1996. Filed as Exhibit (g)(2) to the 
             Schedule 13E-4 filed by Neozyme II Acquisition Corp. on September 27, 1996 and 
             incorporated herein by reference.

<FN>
- ---------------
*  Previously filed.
</TABLE>
 
                                        5
<PAGE>   6
 
                                   SIGNATURE
 
     After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.
 

October 29, 1996                            NEOZYME II CORPORATION
 

                                            By:      /s/ PAUL M. EDWARDS
                                               ------------------------------ 
                                                       PAUL M. EDWARDS
                                                   President and Treasurer
 


                                            GENZYME CORPORATION
 


                                            By:      /s/ PETER WIRTH
                                               ------------------------------
                                                        PETER WIRTH
                                              Executive Vice President, Legal
                                                        Affairs
                                                  and Chief Legal Counsel
 


                                            NEOZYME II ACQUISITION CORP.


 
                                            By:      /s/ PETER WIRTH
                                               ------------------------------ 
                                                        PETER WIRTH
                                                         Secretary
 
                                        6
<PAGE>   7
 
                                 EXHIBIT INDEX
 
<TABLE>
<CAPTION>
EXHIBIT NO.                                    DESCRIPTION                              PAGE NO.
- -----------         ------------------------------------------------------------------  --------
<S>           <C>   <C>                                                                    <C>
(b)(1)        --    Report of Robertson, Stephens & Company LLC.                           *  

(b)(2)        --    Opinion of Robertson, Stephens & Company LLC Set forth in Annex        --
                    II to the Offer to Purchase filed as Exhibit (a)(1) to the
                    Schedule 14D-1 filed by Genzyme Corporation and Neozyme II
                    Acquisition Corp. on September 27, 1996 and incorporated herein
                    by reference.

(b)(3)        --    Report of Hambrecht and Quist LLC.                                     *

(b)(4)        --    Opinion of Hambrecht and Quist LLC.                                    *

(c)(1)        --    Purchase Agreement dated as of September 20, 1996 by and among         --
                    Genzyme Corporation, Neozyme II Acquisition Corp. and Neozyme II
                    Corporation. Filed as Exhibit A to Amendment No. 2 to the Schedule
                    13D filed by Genzyme Corporation on September 24, 1996 and
                    incorporated herein by reference.

(c)(2)        --    Technology License Agreement dated April 28, 1992 between Genzyme      --
                    Corporation and Neozyme II Corporation. Filed as Exhibit 28.7 to
                    the Genzyme Corporation Quarterly Report on Form 10-Q for the
                    quarter ended March 31, 1992 and incorporated herein by reference.

(c)(3)        --    Research and Development Agreement dated as of April 28, 1992          --
                    between Genzyme Corporation and Neozyme II Corporation. Filed as
                    Exhibit 28.8 to the Genzyme Corporation Quarterly Report on Form
                    10-Q for the quarter ended March 31, 1992 and incorporated herein
                    by reference.

(c)(4)        --    Purchase Option Agreement dated April 28, 1992 between Genzyme         --
                    Corporation and certain other parties named therein. Filed as
                    Exhibit 28.9 to the Genzyme Corporation Quarterly Report on Form
                    10-Q for the quarter ended March 31, 1992 and incorporated herein
                    by reference.

(c)(5)        --    Administrative Agreement dated April 28, 1992 between Genzyme          --
                    Corporation and Neozyme II Corporation. Filed as Exhibit 28.10 to
                    the Genzyme Corporation Quarterly Report on Form 10-Q for the
                    quarter ended March 31, 1992 and incorporated herein by reference.

(c)(6)        --    Series 1992 Note of Neozyme II Corporation dated April 28, 1992.       --
                    Filed as Exhibit 28.11 to the Genzyme Corporation Quarterly Report
                    on Form 10-Q for the quarter ended March 31, 1992 and incorporated
                    herein by reference.

(c)(7)        --    Services Agreement dated April 28, 1992 between Genzyme                --
                    Corporation and Neozyme II Corporation. Filed as Exhibit 10.5 to
                    the Genzyme Corporation Annual Report on Form 10-K for the year
                    ended December 31, 1993 and incorporated herein by reference.

(c)(8)        --    Amendment No. 1 dated as of August 11, 1993 to Technology License      --
                    Agreement and Research and Development Agreement between Neozyme
                    II Corporation and Genzyme Corporation. Filed as Exhibit 10.42 to
                    the Genzyme Corporation Annual Report on Form 10-K for the year
                    ended December 31, 1993 and incorporated herein by reference.

(c)(9)        --    License and Development Agreement dated as of August 11, 1993          --
                    between Genzyme Corporation and Univax Biologics, Inc. Filed as
                    Exhibit 10.19 to the Form 10-Q of Univax Biologics, Inc. for the
                    quarter ended September 30, 1993 (File No. 0-19748) and
                    incorporated herein by reference. Confidential treatment has been
                    granted for the deleted portions of this Exhibit.

(d)(1)        --    Offer to Purchase dated September 27, 1996. Filed as Exhibit           --
                    (a)(1) to the Schedule 14D-1 filed by Genzyme Corporation and
                    Neozyme II Acquisition Corp. on September 27, 1996 and
                    incorporated herein by reference.
</TABLE>
 
                                       7
<PAGE>   8
 
<TABLE>
<CAPTION>
EXHIBIT NO.                                    DESCRIPTION                              PAGE NO.
- -----------                                    -----------                              --------
<S>           <C>   <C>                                                                 <C>
(d)(2)        --    Letter of Transmittal. Filed as Exhibit (a)(2) to the Schedule         --
                    14D-1 filed by Genzyme Corporation and Neozyme II Acquisition
                    Corp. on September 27, 1996 and incorporated herein by
                    reference.

(d)(3)        --    Notice of Guaranteed Delivery. Filed as Exhibit (a)(3) to the          --
                    Schedule 14D-1 filed by Genzyme Corporation and Neozyme II
                    Acquisition Corp. on September 27, 1996 and incorporated
                    herein by reference.

(d)(4)        --    Letter from Robertson, Stephens & Company L.P. to Brokers,             --
                    Dealers, Banks, Trust Companies and Other Nominees. Filed as
                    Exhibit (a)(4) to the Schedule 14D-1 filed by Genzyme Corporation
                    and Neozyme II Acquisition Corp. on September 27, 1996 and
                    incorporated herein by reference.

(d)(5)        --    Letter to Clients for Use by Brokers, Dealers, Banks, Trust            --
                    Companies and Other Nominees. Filed as Exhibit (a)(5) to the
                    Schedule 14D-1 filed by Genzyme Corporation and Neozyme II
                    Acquisition Corp. on September 27, 1996 and incorporated
                    herein by reference.

(d)(6)        --    Guidelines for Certification of Taxpayer Identification Number on      --
                    Substitute Form W-9. Filed as Exhibit (a)(6) to the Schedule 14D-1
                    filed by Genzyme Corporation and Neozyme II Acquisition Corp.
                    on September 27, 1996 and incorporated herein by reference.

(d)(7)        --    Press Release of Genzyme Corporation dated September 6, 1996.          --
                    Filed as Exhibit G to Amendment No. 1 to the Schedule 13D filed by
                    Genzyme Corporation on September 6, 1996 and incorporated herein
                    by reference.

(d)(8)        --    Press Release of Genzyme Corporation dated September 23, 1996.         --
                    Filed as Exhibit B to Amendment No. 2 to the Schedule 13D filed by
                    Genzyme Corporation on September 24, 1996 and incorporated herein
                    by reference.

(d)(9)        --    Summary Advertisement dated September 27, 1996. Filed as Exhibit       --
                    (a)(10) to the Schedule 14D-1 filed by Genzyme Corporation and
                    Neozyme II Acquisition Corp. on September 27, 1996 and
                    incorporated herein by reference.

(d)(10)       --    Press Release of Genzyme Corporation dated September 27, 1996.         --
                    Filed as Exhibit (a)(9) to the Schedule 140-1 filed by Genzyme
                    Corporation and Neozyme II Acquisition Corp. on September 27, 1996 
                    and incorporated herein by reference.

(d)(11)       --    Press Release of Genzyme Corporation dated October 29, 1996. Filed 
                    as Exhibit (a)(11) to Amendment No. 2 to Schedule 14D-1 filed by 
                    Genzyme Corporation and Neozyme II Acquisition Corp. on October 29, 
                    1996 and incorporated herein by reference.                             --

   (e)        --    Description of appraisal rights and procedures. Set forth in Annex     --
                    III to the Offer to Purchase filed as Exhibit (a)(1) to the 
                    Schedule 14D-1 filed by Genzyme Corporation and Neozyme II 
                    Acquisition Corp. on September 27, 1996 and incorporated herein 
                    by reference.

(g)(1)        --    Audited financial statements (and related notes) for Neozyme II         *
                    Corporation as of December 31, 1994 and 1995 and for the years 
                    ended December 31, 1993, 1994 and 1995, and unaudited financial 
                    statements (and related notes) for Neozyme II Corporation as of 
                    June 30, 1996 and for the six months ended June 30, 1995 and 
                    1996. 

(g)(2)        --    Audited financial statements (and related notes) for Genzyme           --
                    Corporation, Genzyme General Division and Genzyme Tissue Repair
                    Division as of December 31, 1994 and 1995 and for the years 
                    ended December 31, 1993, 1994 and 1995, and unaudited financial 
                    statements (and related notes) for Genzyme Corporation, Genzyme 
                    General Division and Genzyme Tissue Repair Division as of 
                    June 30, 1996 and for the six months ended June 30, 1995 and 
                    1996. Filed as Exhibit (g)(1) to the Schedule 13E-4 filed by 
                    Neozyme II Acquisition Corp. on September 27, 1996 and 
                    incorporated herein by reference.

(g)(3)        --    Pro forma financial statements (and related notes) for Genzyme         --
                    Corporation and Genzyme General Division as of June 30, 1996 
                    and for the year ended December 31, 1995 and for the six months 
                    ended June 30, 1996.  Filed as Exhibit (g)(2) to the 
                    Schedule 13E-4 filed by Neozyme II  Acquisition Corp. on 
                    September 27, 1996 and incorporated herein by reference.
- ------------
*  Previously filed.

</TABLE>
 
                                       8


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