GENZYME CORP
SC 13D/A, 1997-01-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                     SECURITIES AND EXCHANGE COMMISSION
                           Washington, D.C. 20549

                            --------------------

                               AMENDMENT NO. 3

                                     TO

                                SCHEDULE 13D

                  Under the Securities Exchange Act of 1934


                             Genzyme Corporation
                              (Name of Issuer)

                                Common Stock
                       (Title of class of securities)

                                 372917 10 4
                               (CUSIP number)

                               Marc L. Berman
                           Swiss Bank Corporation
                           141 West Jackson Blvd.
                           Chicago, Illinois 60604
                               (312) 554-5377
               (Name, address and telephone number of persons
              authorized to receive notices and communications)

                              December 31, 1996
           (Date of event which requires filing of this statement)

        If the filing person has previously filed a statement on Schedule
   13G to report  the acquisition which  is the subject of  this Schedule
   13D, and is filing  this schedule because of Rule  13d-1(b)(3) or (4),
   check the following box  [  ].

        Check the following box if a fee is being paid with the statement
   [  ].
    
                       (continued on following pages) 

                             (Page 1 of 7 Pages)<PAGE>





   CUSIP No. 372917 10 4    13D                       Page 2 of 7 Pages


        1    Name of Reporting Persons
             S.S. or I.R.S. Identification Nos. of Above Persons
                  Swiss Bank Corporation (13-5424347)

        2    Check the Appropriate Box if a Member of a Group  (a) [  ]
                                                               (b) [  ]

        3     SEC Use Only


        4    Source of Funds
                  OO

        5    Check Box if Disclosure of Legal Proceedings is Required
             Pursuant to Item 2(d) or 2(e) [  ]

        6    Citizenship or Place of Organization
                            Swiss banking corporation

             Number of Shares Beneficially Owned by each Reporting Person
             with

        7    Sole Voting Power
                                           0
                                      -----------------
        8     Shared Voting Power
                                        2,256,150  
                                      -----------------
        9    Sole Dispositive Power
                                           0
                                      -----------------
        10   Shared Dispositive Power
                                        2,256,150  
                                      -----------------
        11   Aggregate Amount Beneficially Owned by Each Reporting Person
                                        2,256,150  
                                      -----------------
        12   Check  Box  if the  Aggregate  Amount in  Row  (11) Excludes
   Certain        Shares  [ ]

        13   Percent of Class Represented by Amount in Row (11)
                                       3.14%  
                                      -------------
        14   Type of Reporting Person
                  BK<PAGE>





                                                                
                                SCHEDULE 13D

        ITEM 1.  SECURITY AND ISSUER.

        This  Schedule  13D relates  to  the  common stock  (the  "Common
   Stock")  of  Genzyme   Corporation,     a  Massachusetts   corporation
   ("Genzyme").  The address of Genzyme s principal executive offices  is
   One Kendall Square, Cambridge, Massachusetts 02139.  

        ITEM 2.  IDENTITY AND BACKGROUND.

        This Schedule 13D is filed by:

             Swiss Bank Corporation ( SBC )
             Aeschemplatz CH-4002 
             Basel
             Switzerland

        Only the items and portions of items that have changed materially
   since the filing by SBC of  its original Schedule 13D with respect  to
   the Common Stock are being amended hereby.





   ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER.

        As of December 31, 1996:

        (a)  SBC was the  beneficial owner of  an aggregate of  2,256,150
             shares  of  Common  Stock, which  constituted  3.14%  of the
             outstanding  shares  of  Common Stock  based  upon  the most
             recent publicly available information regarding Genzyme.

        (b)  SBC  had shared power  to vote (or  to direct  the vote) and
             shared power to  dispose (or direct  the disposition) of  an
             aggregate of 2,256,150 shares.

        (c)  Schedule  B describes  each of  the  transactions in  Common
             Stock, and in warrants and options to purchase Common Stock,
             that (i) were effected since  December 9, 1996, and (ii) had
             the net  effect of  reducing SBC s  beneficial ownership  of
             Common  Stock to  less than  5.0% of the  outstanding shares
             thereof at  December 31, 1996.   All transactions  in Common
             Stock occurred on the NASDAQ National Market System, Chicago
             Stock Exchange,  Instinet and/or  directly  with buying  and
             selling brokers.




                                      3<PAGE>







                                  SIGNATURE

        After  reasonable inquiry  and to  the best  of my  knowledge and
   belief, we certify that the information set forth in this statement is
   true, complete and correct.

                                 SWISS BANK CORPORATION



   January 10, 1997              By: /s/ Mario Cueni
                                    ---------------------------------


                                 Its: Legal Advisor
                                     ---------------------------------

                                 By: /s/ Roberto Battegay
                                     ----------------------------------

                                 Its: Legal Advisor
                                     ---------------------------------





























                                      4<PAGE>






                                 SCHEDULE B
                                 ----------
                       COMMON STOCK PURCHASED AND SOLD
                           SINCE DECEMBER 9, 1996

           Transaction     Trade Date    Shares       Unit Price

           SL                12/09/96    25,000           25.375

           SL                12/09/96    25,000           25.375
           BY                12/10/96    33,000            25.75
           BY                12/11/96       800            24.75
           SL                12/13/96     1,700            24.00
           BY                12/13/96       300            24.00

           BY                12/16/96    16,200            24.00
           BY                12/16/96     1,700            23.50
           BY                12/16/96     1,700            23.50
           BY                12/16/96     1,700            23.50
           BY                12/16/96     1,900            23.50

           SL                12/18/96     7,000            23.50
           SL                12/19/96       400            24.50
           SL                12/19/96       300            24.50
           BY                12/19/96     5,000            24.75
           BY                12/19/96     5,100            24.75

           BY                12/19/96     5,000            24.75
           BY                12/19/96     4,900            24.75
           SL                12/19/96       300            24.50
           BY                12/20/96       700           25.375
           SL                12/20/96     3,900           25.375

           BY                12/20/96     6,500            25.50
           BY                12/20/96     4,900            25.50
           BY                12/20/96     4,800            25.50
           BY                12/20/96     4,900            25.50
           BY                12/20/96     4,800            25.50

           SL                12/20/96    36,200            25.25
           BY                12/20/96    20,000            25.25
           SL                12/23/96       700            23.00
           BY                12/27/96    11,500           22.375
           BY                12/31/96     2,200            22.00








                                      5<PAGE>





                   WARRANTS PURCHASED, SOLD AND EXERCISED
                           SINCE DECEMBER 9, 1996

           Transaction     Trade Date     Shares      Unit Price

           BY                12/10/96        300           13.75

           BY                12/10/96        500         14.5625
           BY                12/10/96     10,000           14.25

           BY                12/11/96        500         12.3125

           BY                12/12/96      1,100           12.50

           BY                12/18/96      2,000           11.00
           BY                12/18/96      3,000           11.50

           BY                12/18/96      2,000          11.625

           BY                12/19/96      1,000           11.75

           BY                12/19/96      3,000           12.00
           SL                12/19/96      2,000           12.00

           BY                12/19/96      1,500          12.125

           BY                12/19/96      2,000           12.25

           BY                12/19/96      2,400           12.00
           SL                12/30/96      1,000            6.00

           EXE*              12/31/96  1,186,160           6.695
   --------------
   *    Indicates the exercise of a warrant  to purchase 1,186,160 shares
        at an  exercise price of $6.695 per  share, which was then offset
        against a short stock position.

















                                      6<PAGE>





                  OPTIONS TO PURCHASE COMMON STOCK EXPIRING
                           SINCE DECEMBER 9, 1996

    Transaction     Trade Date      Options          Unit Price

    EXP*                12/21/96      1,000               --

   -------------
   *    Indicates the expiration of 1,000 unexercised options to purchase
        Common Stock.




   BY:       Purchase
   SL:       Sale
   SI:       Transfer from Client
   SP:       Received in Stock Split
   EXE:      Exercise of a Right to Purchase
   EXP:      Expiration of a Right to Purchase

































                                      7<PAGE>


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