GENZYME CORP
SC 13G, 1997-12-08
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G 

                   Under the Securities Exchange Act of 1934
                              (Amendment No.    )

                          GENZYME CORP. TISSUE REPAIR
                    ---------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
                    ---------------------------------------
                         (Title of Class of Securities)

                                   372917401
                               ------------------
                                 (CUSIP Number)


Check the following box if a fee is being paid with this statement [X].  (A fee
is not required only if the filing person:  (1) has a previous statement on
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


                       (Continued on following pages(s))
<PAGE>
                                  SCHEDULE 13G 

CUSIP NO. 372917401
- --------------------------------------------------------------------------------

1)   Name of Reporting Person           
     S.S. or I.R.S Identification

     AMERINDO INVESTMENT ADVISORS INC., a California corporation, AMERINDO 
     INVESTMENT ADVISORS, INC., a Panama corporation, ALBERTO W. VILAR and 
     GARY A. TANAKA, who disaffirm the existence of any group and who are 
     sometimes collectively referred to as the "Reporting Persons."

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     See Item 4 of separate cover pages for Reporting Persons

- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                          None   
Beneficially Owned 
by Each Reporting   (6)  Shared Voting Power
Person with         
                    1,757,500 shares in the aggregate for all Reporting Persons
                    and as to all of which beneficial ownership is disclaimed

                    (7)  Sole Dispositive Power                     None

                    (8)  Shared Dispositive Power                    

                    1,757,500 shares in the aggregate for all Reporting Persons
                    and as to all of which beneficial ownership is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person

     1,757,500 shares in the aggregate for all Reporting Persons and as to
     all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                   11.08%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                            IA, IN
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>

                                  SCHEDULE 13G 

CUSIP NO.   372917401

- --------------------------------------------------------------------------------

1)   Name of Reporting Person           
     S.S. or I.R.S Identification

     AMERINDO INVESTMENT ADVISORS INC.

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     California
- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                           None
Beneficially Owned  
by Each Reporting   (6)  Shared Voting Power                         
Person with         
                    1,722,500 shares, as to all of which beneficial ownership 
                    is disclaimed

                    (7)  Sole Dispositive Power                      None

                    (8)  Shared Dispositive Power                    

                    1,722,500 shares, as to all of which beneficial ownership
                    is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     1,722,500 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                   10.86%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IA
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>


                                  SCHEDULE 13G 

CUSIP NO.   372917401

- --------------------------------------------------------------------------------

1)   Name of Reporting Person        
     S.S. or I.R.S Identification

     AMERINDO INVESTMENT ADVISORS, INC.

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     Panama
- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                           None
Beneficially Owned  
by Each Reporting   (6)  Shared Voting Power                         
Person with
                    35,000 shares, as to all of which beneficial ownership is
                    disclaimed
                             
                    (7)  Sole Dispositive Power                      None

                    (8)  Shared Dispositive Power                    
                    
                    35,000 shares, as to all of which beneficial ownership is
                    disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     35,000 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                    0.22%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IA
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>


                                  SCHEDULE 13G 

CUSIP NO.   372917401

- --------------------------------------------------------------------------------

1)   Name of Reporting Person        
     S.S. or I.R.S Identification

     ALBERTO W. VILAR

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     United States
- --------------------------------------------------------------------------------

Number of Shares    
Beneficially Owned  (5)  Sole Voting Power                            None
by Each Reporting   
Person with         (6)  Shared Voting Power

                    1,757,500 shares, as to all of which beneficial ownership
                    is disclaimed

                    (7)  Sole Dispositive Power                       None

                    (8)  Shared Dispositive Power                    

                    1,757,500 shares, as to all of which beneficial ownership 
                    is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     1,757,500 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                   11.08%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IN
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>

                                  SCHEDULE 13G 

CUSIP NO.   372917401

- --------------------------------------------------------------------------------

1)   Name of Reporting Person        
     S.S. or I.R.S Identification

     GARY A. TANAKA

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     United States
- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                           None
Beneficially Owned  
by Each Reporting   (6)  Shared Voting Power                         
Person with         
                    1,757,500 shares, as to all of which beneficial ownership 
                    is disclaimed

                    (7)  Sole Dispositive Power                      None

                    (8)  Shared Dispositive Power                    

                    1,757,500 shares, as to all of which beneficial ownership 
                    is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     1,757,500 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                   11.08%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IN
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>





Item 1.
- ------

     (a) The name of issuer as to whose securities this statement relates is
Genzyme Corp. Tissue Repair (the "Issuer").

     (b) The address of Issuer's principal place of business is One Kendall
Square, Cambridge, MA 02139.


Item 2.
- -------

     (a-c) This statement is being filed by Amerindo Investment Advisors Inc., a
California corporation whose principal executive offices are located at One
Embarcadero Center, Suite 2300, San Francisco, California, 94111 ("Amerindo"),
Amerindo Investment Advisors, Inc., a Panama corporation, whose principal 
executive offices are located at Edificio Sucre, Calle 48 Este, Bella Vista, 
Apartado 6277, Panama 5, Panama ("Amerindo Panama"), Alberto W. Vilar
and Gary A. Tanaka (sometimes hereinafter collectively referred to as the
"Reporting Persons").  Although this statement is being made jointly by
the Reporting Persons, each of them expressly disaffirms membership in any 
group under Rule 13d-5 under the Securities Exchange Act of 1934, as amended 
(the "Exchange Act"), or otherwise.  Amerindo and Amerindo Panama are sometimes 
hereinafter collectively referred to as the "Advisor Entities."

           Each of the Advisor Entities is an investment advisor, and all of the
subject securities have been purchased by the Advisor Entities in the ordinary 
course of their respective businesses as investment advisors and not with the 
purpose of effecting change or influencing the control of the issuer or in 
connection with or as a participant in any transaction having such purpose or 
effect, including any transaction subject to Rule 13d-3(b) under the Exchange 
Act.  Amerindo is registered as an investment advisor under the Investment 
Advisors Act of 1940, as amended.  Messrs. Vilar and Tanaka are the sole 
shareholders and directors of each of the Advisor Entities.  Because each of 
the Advisor Entities is obligated to act in the best interests of its 
respective clients and in accordance with the respective mandates of those 
clients, there is no agreement between or among any of the Reporting Persons to 
act together with respect to the issuer or its securities, except that they 
may, from time to time and provided that transactions are otherwise being 
effected at the same time, aggregate orders for client accounts in order to 
receive more favorable trading terms.

     (d-e) This statement is being filed as to the Common Stock of 
Genzyme Corp. Tissue Repair, Cusip Number 372917401.

<PAGE>

Item 3.  If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b),
- ------   check whether the person filing is a:

     (a-g) Inapplicable.

     (h)   This statement is being filed jointly by the Reporting Persons, 
although each of them expressly disaffirms membership in any group under Rule
13d-5 under the Exchange Act.

Item 4.  Ownership.
- ------   ---------

     (a-c) The following table sets forth for each of the Advisor Entities the 
aggregate number of shares of the Common Stock of the Issuer beneficially owned 
by such person as of November 28, 1997, and the percentage which such shares 
constitute of the total number of shares outstanding, as reflected on the 
Issuer's Form 10Q for the Quarter ended September 30, 1997, unless based on
more recent information obtained directly from the Issuer (with beneficial 
ownership determined as set forth in Rule 13d-3 under the Exchange Act, but 
with beneficial ownership being expressly disclaimed). Messrs. Vilar and 
Tanaka, as the sole shareholders and directors of the Advisor Entities, share 
with each other investment and dispositive power as to all of the shares shown 
as owned by the Advisor Entities, who otherwise have sole investment and 
dispositive power with respect thereto, except that each client of the Advisor 
Entities has the unilateral right to terminate the advisory agreement with the 
Advisor Entity in question on notice which typically need not exceed 30 days.  


Name                         No. of Shares                   Percent of Class
- ----                         -------------                   ----------------

Amerindo                       1,722,500                           10.86%

Amerindo Panama                   35,000                            0.22%

Alberto W. Vilar               1,757,500                           11.08%

Gary A. Tanaka                 1,757,500                           11.08%




<PAGE>


Item 5.  Ownership of Five Percent or Less of a Class.
- ------   --------------------------------------------

         Inapplicable.


Item 6.  Ownership of More Than Five Percent on Behalf of Another Person.
- ------   ---------------------------------------------------------------

         The subject shares are all owned by clients of the Advisor Entities.  
No such person's interest in the securities included in this report exceeds 5% 
of the class outstanding.

Item 7.  Identification and Classification of the Subsidiary Which
- ------   ---------------------------------------------------------
         Acquired the Security Being Reported on By the Parent Holding
         -------------------------------------------------------------
         Company.
         -------

         Inapplicable.


Item 8.  Identification and Classification of Members of the Group.
- ------   ---------------------------------------------------------

    (a-c) This statement is being filed by Amerindo Investment Advisors Inc., a
California corporation whose principal executive offices are located at One
Embarcadero Center, Suite 2300, San Francisco, California, 94111 ("Amerindo"),
Amerindo Investment Advisors, Inc., a Panama corporation, whose principal 
executive offices are located at Edificio Sucre, Calle 48 Este, Bella Vista, 
Apartado 6277, Panama 5, Panama ("Amerindo Panama"), Alberto W. Vilar and 
Gary A. Tanaka (sometimes hereinafter collectively referred to as the 
"Reporting Persons").  Although this statement is being made jointly by the 
Reporting Persons, each of them expressly disaffirms membership in any group 
under Rule 13d-5 under the Securities Exchange Act of 1934, as amended (the 
"Exchange Act"), or otherwise.  Amerindo and Amerindo Panama are sometimes 
hereinafter collectively referred to as the "Advisor Entities."

          Each of the Advisor Entities is an investment advisor, and all of the
subject securities have been purchased by the Advisor Entities in the ordinary 
course of their respective businesses as investment advisors and not with the 
purpose of effecting change or influencing the control of the issuer or in 
connection with or as a participant in any transaction having such purpose or 
effect, including any transaction subject to Rule 13d-3(b) under the Exchange 
Act.  Amerindo is registered as an investment advisor under the Investment 
Advisors Act of 1940, as amended.  Messrs. Vilar and Tanaka are the sole 
shareholders and directors of each of the Advisor Entities.  Because each of 
the Advisor Entities is obligated to act in the best interests of its 
respective clients and in accordance with the respective mandates of those 
clients to act in the best interest of the beneficiaries thereof, there is no 
agreement between or among any of the Reporting Persons to act together with 
respect to the issuer or its securities, except that they may, from time to 
time and provided that transactions are otherwise being effected at the same 
time, aggregate orders for client accounts in order to receive more favorable 
trading terms.

     (d-e) This statement is being filed as to the Common Stock of 
Genzyme Corp. Tissue Repair, Cusip Number 372917401.


Item 9.   Notice of Dissolution of Group.
- ------    ------------------------------

          Inapplicable.

<PAGE>

Item 10.  Certification.
- -------   -------------

     By signing below, the undersigned certify that, to the best of their 
knowledge and belief, the securities referred to above were acquired in the 
ordinary course of business and were not acquired for the purpose of and do 
not have the effect of changing or influencing the control of the issuer of 
such securities and were not acquired in connection with or as a participant 
in any transaction having such purpose or effect.


                                 SIGNATURES

          After reasonable inquiry and to the best of the knowledge and belief
of the undersigned, we certify that the information set forth in this
statement is true, complete and correct.

                                         AMERINDO INVESTMENT ADVISORS INC., 
                                         a California corporation


                                         By: /s/ Alberto W. Vilar
                                             -------------------------------
                                             ALBERTO W. VILAR, PRESIDENT

 
                                          AMERINDO INVESTMENT ADVISORS, INC.,
                                          a Panama corporation


                                          By: /s/ Alberto W. Vilar
                                              ------------------------------
                                              ALBERTO W. VILAR, DIRECTOR


                                          By: /s/ Alberto W. Vilar
                                              ------------------------------
                                              ALBERTO W. VILAR

                                              /s/ Gary A. Tanaka
                                              ------------------------------
                                              GARY A. TANAKA

<PAGE>

                                   EXHIBIT A

                           GENZYME CORP. TISSUE REPAIR

                                  COMMON STOCK

                                   372917401

                                        
We hereby agree that the within Statement on Schedule 13G regarding our 
beneficial ownership of Common Stock is filed on behalf of each of us.


                                        AMERINDO INVESTMENT ADVISORS INC.,
                                        a California corporation

                                        By:  /s/ Alberto W. Vilar
                                            ---------------------------------
                                             ALBERTO W. VILAR, PRESIDENT


                                        AMERINDO INVESTMENT ADVISORS, INC.,
                                        a Panama corporation

                                        By:  /s/ Alberto W. Vilar
                                            ---------------------------------
                                             ALBERTO W. VILAR, DIRECTOR



                                        By: /s/ Alberto W. Vilar
                                            ---------------------------------
                                            ALBERTO W. VILAR

                                            /s/ Gary A. Tanaka
                                            ---------------------------------
                                            GARY A. TANAKA



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