<PAGE>
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED
PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS
THERETO FILED PURSUANT TO RULE 13d-2(b)
(Amendment No. )(1)
GENZYME CORPORATION
- --------------------------------------------------------------------------------
(Name of Issuer)
Genzyme Molecular Oncology Division Common Stock
- --------------------------------------------------------------------------------
(Title of Class of Securities)
372917500
- --------------------------------------------------------------------------------
(CUSIP Number)
December 31, 1998
- --------------------------------------------------------------------------------
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
[ ] Rule 13d-1 (b)
[X] Rule 13d-1 (c)
[ ] Rule 13d-1 (d)
- ----------
(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
Page 1 of 20 Pages
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 2 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 573,669
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
573,669
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
573,669
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
4.5%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-2-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 3 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 573,669
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
573,669
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
573,669
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
4.5%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-3-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 4 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 65,508
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
65,508
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
65,508
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
.05%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-4-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 5 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 65,508
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
65,508
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
65,508
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
.05%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-5-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 6 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 19,237
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
19,237
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
19,237
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
.15%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-6-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 7 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 19,237
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
19,237
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
19,237
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
.15%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-7-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 8 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
James H. Cavanaugh, Ph.D.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 658,414
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
658,414
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
658,414
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-8-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 9 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
Harold R. Werner
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 658,414
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
658,414
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
658,414
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-9-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 10 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
William Crouse
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 658,414
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
658,414
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
658,414
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-10-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 11 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
John W. Littlechild
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 658,414
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
658,414
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
658,414
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
5.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-11-
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 12 of 20 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
Mark Leschly
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 84,745
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
84,745
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
84,745
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
.68%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
-12-
<PAGE>
Page 13 of 20
Item 1.
(a) Name of Issuer:
Genzyme Corporation
(b) Address of Issuer's Principal Executive Offices:
Genzyme Corporation
One Kendall Square
Cambridge, MA 02139
Item 2.
(a) Name of Person Filing:
HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners II,
L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV III"),
HealthCare Partners III, L.P. ("HCP III"), HealthCare Ventures IV,
L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"), Dr.
Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly. See
attached Exhibit A which is a copy of their agreement in writing to
file this statement on behalf of each of them.(1)
(b) Address of Principal Business Office or, if none, Residence:
The business address for HCV II, HCP II, HCV III, HCP III, HCV IV,
HCP IV and Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau
Street, Princeton, New Jersey 08542. The business address for
Messrs. Littlechild and Leschly is One Kendall Square, Building 300,
Cambridge, Massachusetts 02139.
(c) Citizenship:
HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are limited
partnerships organized under the laws of the State of Delaware. Dr.
Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are
each United States citizens.
- --------
(1) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general
partners of HCP II, which is the general partner of HCV II, and Dr. Cavanaugh
and Messrs. Werner, Littlechild, Crouse and Leschly are general partners of each
of HCP III and HCP IV, the general partner of each of HCV III and HCV IV,
respectively, the record holder of Issuer's securities.
-13-
<PAGE>
Page 14 of 20
(d) Title of Class of Securities:
Genzyme Molecular Oncology Division Common Stock ("Shares").
(e) CUSIP Number:
372917500
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or
13d-2(b), check whether the person filing is a:
Inapplicable
If this statement is filed pursuant to Rule 13d-1(c), check this
box. [X]
Item 4. Ownership.
(a) Amount Beneficially Owned:
As of December 31, 1998: HCV II and HCP II beneficially owned
573,669 Shares of Issuer's Common Stock; HCV III and HCP III
beneficially owned 65,508 Shares of Issuer's Common Stock; HCV
IV and HCP IV beneficially owned 19,237 Shares of Issuer's
Common Stock; Dr. Cavanaugh and Messrs. Werner, Littlechild
and Crouse beneficially owned 658,414 Shares of Issuer's
Common Stock; and Mr. Leschly beneficially owned 84,745 Shares
of Issuer's Common Stock.
(b) Percent of Class:
As of December 31, 1998: the 573,669 Shares beneficially owned
by HCV II and HCP II constitute 4.5% of Issuer's Shares
outstanding; the 65,508 Shares beneficially owned by HCV III
and HCP III constitute .05% of the Issuer's Shares
outstanding; the 19,237 Shares beneficially owned by HCV IV
and HCP IV constitute .15% of Issuer's Shares outstanding; the
658,414 Shares beneficially owned by Dr. Cavanaugh and Messrs.
Werner, Littlechild and Crouse constitute .05% of Issuer's
Shares outstanding; and the 84,745 Shares beneficially owned
by Mr. Leschly constitute .68% of Issuer's Shares outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Inapplicable
-14-
<PAGE>
Page 15 of 20
(ii) shared power to vote or to direct the vote: HCV II,
HCP II, Dr. Cavanaugh and Messrs. Werner,
Littlechild, and Crouse share the power to vote or
direct the vote of those Shares owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
vote or direct the vote of those Shares owned by HCV
III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
vote or direct the vote of those Shares owned by HCV
IV.
(iii) sole power to dispose or to direct the disposition of:
Inapplicable
(iv) shared power to dispose of or to direct the
disposition of: HCV II, HCP II, Dr. Cavanaugh and
Messrs. Werner, Littlechild and Crouse share the
power to dispose of or direct the disposition of
those Shares owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
dispose of or direct the disposition of those Shares
owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
Littlechild, Crouse and Leschly share the power to
dispose of or direct the disposition of those Shares
owned by HCV IV.
Item 5. Ownership of Five Percent or less of a Class:
Inapplicable.
Item 6. Ownership of More than Five Percent on Behalf of Another Person:
Inapplicable.
Item 7. Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on by the Parent Holding Company:
Inapplicable.
-15-
<PAGE>
Page 16 of 20
Item 8. Identification and Classification of Members of the Group:
Inapplicable.
Item 9. Notice of Dissolution of Group:
Inapplicable.
Item 10. Certification:
By signing below I certify that, to the best of my knowledge
and belief, the securities referred to below were not acquired
and were not held for purpose of or with the effect of
changing or influencing the control of the issuer of the
securities and were not acquired and are not held in
connection with or as a participant in any transaction having
that purpose or effect.
-16-
<PAGE>
Page 17 of 20
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Dated: February 12, 1999 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners II, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners III, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners IV, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 By: *
Princeton, New Jersey -------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 12, 1999 By: *
Princeton, New Jersey -------------------------------
Harold R. Werner
-17-
<PAGE>
Page 18 of 20
Dated: February 12, 1999 By: *
Cambridge, Massachusetts -------------------------------
John W. Littlechild
Dated: February 12, 1999 By: *
Princeton, New Jersey -------------------------------
William Crouse
Dated: February 12, 1999 By: *
Cambridge, Massachusetts -------------------------------
Mark Leschly
--------------------------
*Signed by Jeffrey Steinberg as Attorney-in-Fact
-18-
<PAGE>
Page 19 of 20
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with regulatory
authorities a Schedule 13G and any future amendments thereto reporting each of
the undersigned's ownership of securities of Genzyme Molecular Oncology Division
and hereby affirm that such Schedule 13G is being filed on behalf of each of the
undersigned.
Dated: February 12, 1999 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners II, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners III, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners IV, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
-19-
<PAGE>
Page 20 of 20
Dated: February 12, 1999 By: *
Princeton, New Jersey --------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 12, 1999 By: *
Princeton, New Jersey --------------------------------
Harold R. Werner
Dated: February 12, 1999 By: *
Cambridge, Massachusetts --------------------------------
John W. Littlechild
Dated: February 12, 1999 By: *
Princeton, New Jersey --------------------------------
William Crouse
Dated: February 12, 1999 By: *
Cambridge, Massachusetts --------------------------------
Mark Leschly
- -------------------
*Signed by Jeffrey Steinberg as Attorney-in-Fact
