<PAGE>
Directors of Genzyme
--------------------
Set forth below is the name, present principal occupation or employment
and the name, principal business and address of any corporation or other
organization in which such employment is conducted of each director of Genzyme.
Unless otherwise indicated, each director is a citizen of the United States.
Henri A. Termeer
Chairman of the Board, President and Chief Executive Officer
Genzyme Corporation
One Kendall Square
Cambridge, Massachusetts 02139
Constantine E. Anagnostopoulos
Managing General Partner
Gateway Associates (venture capital firm)
8000 Maryland Avenue, Suite 1190
Clayton, MO 63105
Douglas A. Berthiaume
Chairman, President and Chief Executive Officer
Waters Corporation (high technology manufacturer of products used for
analysis and purification)
34 Maple Street
Milford, Massachusetts 01757
Henry E. Blair
President and Chief Executive Officer
Dyax Corp. (bioseparation, pharmaceutical discovery and development
company)
One Kendall Square, Building 600, 5th Floor
Cambridge, Massachusetts 02139
Robert J. Carpenter
Chairman
GelTex Pharmaceuticals, Inc. (pharmaceutical development company)
153 Second Avenue
Waltham, Massachusetts 02451
Charles L. Cooney
Professor of Chemical and Biochemical Engineering
Massachusetts Institute of Technology
25 Ames Street
Building 66-Room 352
Cambridge, Massachusetts 02139
Victor J. Dzau
Professor of the Theory and Practice of Physic
Harvard Medical School
25 Shattuck Street
Boston, Massachusetts 02115
(Page 11 of 12 pages)
<PAGE>
Executive Officers of Genzyme
-----------------------------
Set forth below is the name and present principal occupation of each of
the executive officers of Genzyme. Unless otherwise indicated, each executive
officer is a citizen of the United States and has as his principal business
address One Kendall Square, Cambridge, Massachusetts 02139.
Henri A. Termeer
Chairman of the Board, President and Chief Executive Officer
Earl M. Collier, Jr.
Executive Vice President, President, Genzyme Surgical Products Division
Zoltan A. Csimma
Senior Vice President, Human Resources
David D. Fleming
Group Senior Vice President, Diagnostic Products
Richard A. Moscicki, M.D.
Senior Vice President, Clinical, Medical and Regulatory Affairs; Chief
Medical Officer
Alan E. Smith, Ph.D.
Senior Vice President, Research; Chief Scientific Officer
Citizenship: United Kingdom
G. Jan van Heek
Executive Vice President, Therapeutics and Genetics
Citizenship: The Netherlands
Peter Wirth
Executive Vice President; Chief Legal Officer; Clerk
Michael S. Wyzga
Senior Vice President, Finance; Chief Financial Officer; Corporate
Controller; Chief Accounting Officer
(Page 12 of 12 pages)
