GENZYME CORP
PRE 14A, 2000-04-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>
                            SCHEDULE 14A INFORMATION

                  Proxy Statement Pursuant to Section 14(a) of
            the Securities Exchange Act of 1934 (Amendment No.    )

<TABLE>
      <S>        <C>
      Filed by the Registrant /X/
      Filed by a Party other than the Registrant / /

      Check the appropriate box:
      /X/        Preliminary Proxy Statement
      / /        Confidential, for Use of the Commission Only (as permitted
                 by Rule 14a-6(e)(2))
      / /        Definitive Proxy Statement
      / /        Definitive Additional Materials
      / /        Soliciting Material Pursuant to Section240.14a-11(c) or
                 Section240.14a-12

                       GENZYME CORPORATION
      -----------------------------------------------------------------------
                 (Name of Registrant as Specified In Its Charter)

      -----------------------------------------------------------------------
           (Name of Person(s) Filing Proxy Statement, if other than the
                                    Registrant)
</TABLE>

Payment of Filing Fee (Check the appropriate box):

<TABLE>
<S>        <C>  <C>
/X/        No fee required.
/ /        Fee computed on table below per Exchange Act Rules 14a-6(i)(1)
           and 0-11.
           (1)  Title of each class of securities to which transaction
                applies:
                ----------------------------------------------------------
           (2)  Aggregate number of securities to which transaction
                applies:
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           (3)  Per unit price or other underlying value of transaction
                computed pursuant to Exchange Act Rule 0-11 (set forth the
                amount on which the filing fee is calculated and state how
                it was determined):
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           (4)  Proposed maximum aggregate value of transaction:
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/ /        Fee paid previously with preliminary materials.
/ /        Check box if any part of the fee is offset as provided by
           Exchange Act Rule 0-11(a)(2) and identify the filing for which
           the offsetting fee was paid previously. Identify the previous
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           (1)  Amount Previously Paid:
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           (3)  Filing Party:
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           (4)  Date Filed:
                ----------------------------------------------------------
</TABLE>
<PAGE>
GENZYME CORPORATION
One Kendall Square
Cambridge, MA 02139
(617) 252-7500

DEAR STOCKHOLDERS:

    We invite you to attend our Annual Meeting of Stockholders to be held on
Thursday, May 25, 2000 at State Street Bank, 225 Franklin Street, Boston,
Massachusetts.

    The enclosed proxy statement explains the agenda for the meeting and voting
information and procedures. It also includes information about our board of
directors and senior management. Please read this booklet carefully. Also
included with this proxy is a copy of our 1999 Annual Report and your proxy
card.

    As we have done in the past, at the annual meeting we will review important
developments in our operations since our last stockholder meeting.

    Whether or not you plan to attend, your vote is very important to us.
Information about voting procedures can be found in the proxy statement. Please
return a signed proxy card or give us instructions by telephone or over the
Internet so that you can be sure your shares will be properly voted.

Sincerely,

Henri A. Termeer
Chairman and
Chief Executive Officer
<PAGE>
        NOTICE OF ANNUAL MEETING OF STOCKHOLDERS OF GENZYME CORPORATION

<TABLE>
<S>       <C>
DATE:     Thursday, May 25, 2000

TIME:     2:00 - 4:00 p.m.

PLACE:    State Street Bank
          Enterprise Room, 5(th) floor
          225 Franklin Street
          Boston, Massachusetts
</TABLE>

PURPOSE:

    - Re-elect one director.

    - Amend our 1990 Equity Incentive Plan to increase the number of shares of
      GZSP Stock available for grant by 175,000 shares.

    - Amend and restate our charter to modify the terms of the GZMO, GZSP and
      GZTR Stock.

    - Act on any other matter that may be properly brought before the meeting.

    Only stockholders of record at the close of business on March 31, 2000 will
be entitled to vote at the meeting.

YOUR BOARD OF DIRECTORS RECOMMENDS A VOTE "IN FAVOR OF" THE THREE PROPOSALS.

    WE INTEND TO HOLD A SPECIAL MEETING OF STOCKHOLDERS IN JUNE. AT THAT
MEETING, YOU WILL BE ASKED TO CONSIDER AND VOTE ON A PROPOSAL TO AMEND AND
RESTATE OUR CHARTER TO:

    - CREATE A NEW SERIES OF COMMON STOCK DESIGNATED AS GENZYME BIOSURGERY
      DIVISION COMMON STOCK;

    - CANCEL GZSP STOCK AND GZTR STOCK;

    - EXCHANGE GZSP STOCK AND GZTR STOCK FOR GENZYME BIOSURGERY DIVISION COMMON
      STOCK; AND

    - TRANSFER THE ASSETS OF GENZYME SURGICAL PRODUCTS AND GENZYME TISSUE REPAIR
      TO GENZYME BIOSURGERY.

    THIS TRANSACTION IS A CONDITION TO A PROPOSED MERGER OF BIOMATRIX, INC. INTO
A SUBSIDIARY OF GENZYME FOR CASH AND GENZYME BIOSURGERY COMMON STOCK, AND THE
ALLOCATION OF THE BIOMATRIX ASSETS TO GENZYME BIOSURGERY. YOU WILL ALSO BE ASKED
TO APPROVE CERTAIN BENEFIT PLAN CHANGES RELATED TO THIS NEW STOCK. WE EXPECT TO
MAIL A PROXY STATEMENT DETAILING THESE TRANSACTIONS TO YOU IN MAY.

PROXY MATERIAL MAILING DATE:
  April 18, 2000

                                          By order of the Board of Directors
                                          PETER WIRTH, CLERK
<PAGE>
                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                PAGE
                                                              --------
<S>                                                           <C>
General Information About Voting............................      4

Stock Ownership.............................................      7

ELECTION OF DIRECTORS.......................................     10

Directors Continuing in Office..............................     10

Director Compensation.......................................     12

Executive Compensation......................................     12

Compensation Committee Report on Executive Compensation.....     12

Summary Compensation Table..................................     16

Option Grants in Last Fiscal Year...........................     17

Aggregated Option Exercises in Last Fiscal Year and Fiscal
  Year-End Option Values....................................     18

Executive Employment Agreements.............................     19

Executive Severance Agreements..............................     19

Stock Performance Graphs....................................     20

PROPOSAL TO AMEND OUR 1990 EQUITY INCENTIVE PLAN............     21

PROPOSAL TO AMEND AND RESTATE OUR CORPORATE CHARTER.........     23

Certain Transactions........................................     31

Section 16(a) Beneficial Ownership Reporting Compliance.....     32

Independent Accountants.....................................     32

Stockholder Proposals.......................................     32

Where You Can Find More Information.........................     33

APPENDICES

Appendix A--Proposed Amended and Restated Articles of
  Organization..............................................    A-1

Appendix B--Massachusetts Appraisal Law.....................    B-1
</TABLE>
<PAGE>
                        GENERAL INFORMATION ABOUT VOTING

Our board of directors is soliciting proxies for the 2000 Annual Meeting of
Stockholders. This proxy statement explains the agenda, voting information and
procedures. Please read it carefully.

In this proxy statement, references to "we," "us," "our," "the company" or
"Genzyme" mean Genzyme Corporation.

WHO CAN VOTE.  Only stockholders of record of each series of Genzyme common
stock at the close of business on March 31, 2000 can vote at the meeting. We
currently have four series of common stock, and each is publicly traded on The
Nasdaq Stock Market-Registered Trademark-. We refer to them in this document by
their ticker symbols:

<TABLE>
<S>                                                           <C>              <C>
- - Genzyme General Division common stock                          is             GENZ Stock
- - Genzyme Molecular Oncology Division common stock               is             GZMO Stock
- - Genzyme Surgical Products Division common stock                is             GZSP Stock
- - Genzyme Tissue Repair Division common stock                    is             GZTR Stock
</TABLE>

QUORUM.  In order to hold and complete the business of the annual meeting, we
must have a majority in interest of the outstanding shares of

    - all four series of common stock, together as a single class, and

    - each of GZMO, GZSP and GZTR Stock, as a separate class

represented at the meeting.

SHARES OUTSTANDING AND VOTING POWER.

<TABLE>
<CAPTION>
                                                    SHARES OUTSTANDING      NUMBER OF          TOTAL
                                                      MARCH 31, 2000     VOTES PER SHARE   VOTING SHARES
                                                    ------------------   ---------------   -------------
<S>                                                 <C>                  <C>               <C>
GENZ Stock........................................      84,773,869            1.00          84,773,869
GZMO Stock........................................      13,624,432            0.08           1,089,955
GZSP Stock........................................      14,900,615            0.61           9,089,375
GZTR Stock........................................      28,655,353            0.06           1,719,321
                                                                                            ----------
  Total...........................................                                          96,672,520
</TABLE>

The number of votes for each series of common stock (other than GZSP Stock,
which did not exist at that time) was set on January 1, 1999 and is reset every
two years in accordance with our charter. The number of votes is based on an
average closing stock price for each series of stock over a defined period of
time.

HOW TO VOTE YOUR SHARES.  There are four ways you can vote your shares:

    - by mail;

    - by telephone;

    - on the Internet; or

    - in person, at the annual meeting.

To vote by mail, simply complete the enclosed proxy card, sign and date it, and
return it in the enclosed self-addressed envelope. Instructions for voting by
telephone or on the Internet can be found on your proxy card. If you hold your
shares through a bank, broker or other nominee, they will give you separate
instructions for voting your shares.

By signing a proxy, you are authorizing us to vote your shares at the meeting in
the manner you direct. If you return a signed proxy without specific voting
instructions, your shares will be voted in favor of the proposals recommended by
the board of directors. If any matters come before the meeting which are not

                                       2
<PAGE>
described in this proxy statement, the proxies will use their own judgment to
determine how to vote your shares.

If your shares are held in a nominee name, you must request a legal proxy from
your nominee as proof of ownership in order to vote at the meeting.

HOW YOU MAY REVOKE YOUR PROXY INSTRUCTIONS.  You may revoke or amend your proxy
before it is voted by writing to us directly, submitting a new proxy with a
later date, or by attending the meeting and voting in person.

WHAT IF YOU GET MORE THAN ONE PROXY CARD?  This means that you have more than
one account at the transfer agent and/or with a nominee. It may also mean that
you hold stock in more than one series of our common stock. Your proxy card
lists the number of shares you are voting. Please sign and return all proxy
cards to be sure that all of your shares are voted.

We recommend you consolidate your holdings under the same name, address and tax
identification number as much as possible. This will eliminate some duplication
of mailings and costs. Please contact your nominee to consolidate accounts, or
our transfer agent, American Stock Transfer and Trust Co., Inc. at
(800) 937-5449.

HOW THE SHARES ARE COUNTED.  Approval of all of the proposals, except the
charter amendment, requires the favorable vote of the majority of votes cast at
the meeting. Abstentions and broker non-votes are counted for determining a
quorum but are not counted for voting purposes. Broker non-votes occur when a
broker returns a proxy but does not have the authority to vote on a particular
proposal without a specific instruction from the owner of the shares.

Approval of the proposal to amend and restate our charter requires:

    - the affirmative vote of a majority of all shares of GENZ, GZMO, GZSP and
      GZTR Stock outstanding and entitled to vote, voting together as one class,
      with:

       - GENZ stockholders having one vote per share;

       - GZMO stockholders having 0.08 vote per share;

       - GZSP stockholders having 0.61 vote per share; and

       - GZTR stockholders having 0.06 vote per share; and

    - for those parts of the amendment specific to the GZMO Stock, GZSP Stock or
      GZTR Stock, adoption will require the favorable vote of a majority of all
      shares outstanding and entitled to vote of that series, each voting as a
      separate class. If the holders of the GZMO Stock, GZSP Stock or GZTR
      Stock, with that series voting separately, do not approve the charter
      amendment, then the terms of that series will not be amended.

Abstentions and broker non-votes will be treated as votes against the charter
amendment.

WHAT IF YOU EXERCISE DISSENTERS' RIGHTS?  As described more fully at page 30,
holders of GZMO, GZSP and GZTR Stock who object to the proposed charter
amendment can demand payment for and appraisal of their shares. Our board of
directors has determined that if the holders of more than 5% of the shares of
any one of those series exercises their appraisal rights, then the amendment
will not be adopted with respect to the specific terms of that series' stock.
Our board of directors, however, has reserved its right to waive that condition
in part or entirely at any time.

COSTS OF SOLICITATION.  We are paying Corporate Investor Communications, a proxy
solicitation firm, $15,000 plus expenses to help us with the solicitation. Our
employees may solicit proxies personally, electronically, by telephone or by
mail. We also reimburse, on request, the fees and expenses of brokers and other
nominees for sending you the proxy material and sending in your vote.

                                       3
<PAGE>
RESULTS OF THE VOTING.  We will announce the results of the voting at the annual
meeting. We will also publish the results in our quarterly report on Form 10-Q
that we will file with the Securities and Exchange Commission in August.

ANNUAL MEETING TO BE BROADCAST ON OUR WEB SITE.  The annual meeting will be
broadcast live over the Internet at our corporate web site at
HTTP://WWW.GENZYME.COM in the "Investor Information--Events" section. To listen
to the meeting you need a computer equipped with speakers and a sound card.

                                       4
<PAGE>
                                STOCK OWNERSHIP

    This table shows how many shares are held by anyone that owns more than 5%
of any series of our common stock. The information in this table is as of
February 29, 2000 and is based on the most recent SEC filings by these entities
as to their ownership of our stock. Unless noted, each stockholder has sole
voting and investment power for the shares listed in the table.

<TABLE>
<CAPTION>
                                                                   NUMBER OF SHARES BENEFICIALLY OWNED
                                                                   -----------------------------------
                                                                       (* INDICATES LESS THAN 1%)
                                                                       --------------------------
                                           GENZ                   GZMO                  GZSP                   GZTR
                                          STOCK         %        STOCK        %         STOCK        %         STOCK        %
                                        ----------   --------   --------   --------   ---------   --------   ---------   --------
<S>                                     <C>          <C>        <C>        <C>        <C>         <C>        <C>         <C>
Baupost Group, Inc. (1)...............           0        *           0        *      1,458,583      9.8             0        *
44 Brattle Street
Cambridge, MA 02139

CitiGroup Inc. (2)....................   2,829,435      3.3     148,379      1.1      1,180,850      7.9             0        *
153 East 53(rd) Street
New York, NY 10043

FMR Corp. (3).........................   7,796,291      9.2           0        *            172        *             0        *
82 Devonshire Street
Boston, MA 02109

Iridian Asset Management, LLC (4).....   4,599,600      5.4           0        *        557,551      3.8             0        *
276 Post Road West
Westport, CT 06880

State of Wisconsin Investment Board          6,100        *           0        *              0        *     3,062,148     10.7
  (5).................................
P.O. Box 7842
Madison, WI 53707

Wellington Management Co., L.L.P.       11,681,859     13.8     906,799      6.7      2,076,822     14.0       492,502      1.7
  (6).................................
75 State Street
Boston, MA 02109
</TABLE>

- --------------------------

(1) Baupost Group, Inc. is an investment management company. No single client of
    Baupost owns more than 5% of the shares listed.

(2) Citigroup Inc. is a holding company and investment manager and advisor for
    Citicorp Bank, and is reporting the shares listed for certain of its
    subsidiaries. Citigroup has sole power to vote 2,350,763 of the shares of
    GENZ Stock and 138,482 of the shares of GZMO Stock listed, and shares voting
    and dispositive power for all of the shares listed, including with:

    - SSB Citi Fund Management LLC, an investment advisor that shares voting and
      dispositive power for 1,020,071 of the shares of GZSP Stock listed; and

    - Salomon Brothers Holdings, Inc., a holding company that shares voting and
      dispositive power for 1,165,703 of the shares of GZSP Stock listed.

    No single client of Citigroup or its subsidiaries owns more than 5% of the
shares listed.

(3) FMR Corp. is a holding company and is reporting the shares listed for
    several subsidiaries, who act as investment advisors. FMR has sole power to
    vote 380,154 shares of the GENZ Stock and 111 shares of the GZSP Stock
    listed. No single client of FMR or its subsidiaries owns more than 5% of the
    shares listed.

(4) Iridian is a registered investment advisor and is reporting the shares
    listed as part of a group that includes:

    - LC Capital Management LLC;

    - CL Investors, Inc.;

    - COLE Partners LLC;

    - Iridian Partners Fund, L.P.;

    - Iridian Private Business Value Equity Fund, L.P.; and

                                       5
<PAGE>
    - David L. Cohen and Harold J. Levy.

    Iridian, LC Capital and CL Investors share voting and dispositive power for
    4,274,400 of the shares of GENZ Stock listed. COLE shares voting and
    dispositive power for 40,600 of the shares of GENZ Stock listed. Iridian
    Partners shares voting and dispositive power for 7,300 of the shares of GENZ
    Stock listed. Iridian Private Business shares voting and dispositive power
    for 40,600 of the shares of GENZ Stock listed. Messrs. Cohen and Levy, who
    are the controlling stockholders of CL Investors, each share voting and
    dispositive power for 4,599,600 of the shares of GENZ Stock listed,
    including 325,200 shares of the GENZ Stock owned by First Eagle Fund of
    America. Iridian has sole power to vote 407,372 of the shares of GZSP Stock
    listed. No single client of Iridian owns more than 5% of the shares listed.

(5) The State of Wisconsin Investment Board is a government agency that manages
    public pension funds.

(6) Wellington Management Co., L.L.P. is a registered investment advisor. Its
    clients can receive or direct the receipt of dividends and proceeds from
    sales of shares disposed of by Wellington Management. No single client owns
    more than 5% of the shares listed. Wellington Management has shared power to
    dispose or to direct the disposition of 11,663,459 shares of GENZ Stock,
    906,799 shares of GZMO Stock and 2,076,822 shares of GZSP Stock, and has
    shared power to vote or to direct the vote with respect to 6,957,639 shares
    of GENZ Stock, 734,849 shares of GZMO Stock, 1,876,122 shares of GZSP Stock
    and 298,685 shares of GZTR Stock.

                           --------------------------

    This table shows how much of each series of our common stock is held by the
executive officers listed in the compensation table on page 16, our directors,
and all of our current executive officers and directors together. It also
includes information about the ownership of Genzyme Transgenics Corporation, a
30% owned subsidiary of Genzyme, whose stock is referred to by its ticker
symbol, GZTC. Unless otherwise noted, each director and officer has sole voting
and investment power for the shares listed. The information in this table is as
of February 29, 2000.
<TABLE>
<CAPTION>
                                                NUMBER OF SHARES BENEFICIALLY OWNED (1)
                                                                       -----------------------------
                                                       (* INDICATES LESS THAN 1%)
                                                                             -----------------------
                                      GENZ                   GZMO                  GZSP
                                      STOCK        %        STOCK        %        STOCK        %
                                    ---------   --------   --------   --------   --------   --------
    <S>                             <C>         <C>        <C>        <C>        <C>        <C>
    Henri A. Termeer (2)..........    738,430       *       71,467        *      229,559      1.5
    Earl M. Collier, Jr. (3)......     79,262       *        6,689        *       50,563        *
    Alan E. Smith.................    151,932       *       17,644        *        3,936        *
    G. Jan van Heek (4)...........    120,756       *        6,399        *        4,124        *
    Peter Wirth...................    149,333       *       20,618        *       52,230        *
    Constantine E.
      Anagnostopoulos.............     42,000       *        2,916        *        1,074        *
    Douglas A. Berthiaume (5).....     44,100       *        7,340        *        3,311        *
    Henry E. Blair................     50,600       *       19,339        *        4,475        *
    Robert J. Carpenter (6).......     29,095       *        3,764        *        1,756        *
    Charles L. Cooney (7).........     15,350       *        4,478        *        2,841        *
    Henry R. Lewis................     34,600       *        2,980        *          465        *
    All current officers and
      directors as a group (15
      people) (8).................  1,704,022     2.0      189,328      1.4      373,064      2.5

<CAPTION>
                                     NUMBER OF SHARES BENEFICIALLY OWNED (1)
                                    -------
                                            (* INDICATES LESS THAN 1%)

                                      GZTR                   GZTC
                                      STOCK        %        STOCK        %
                                    ---------   --------   --------   --------
    <S>                             <C>         <C>        <C>        <C>
    Henri A. Termeer (2)..........    973,367     3.4       32,500       *
    Earl M. Collier, Jr. (3)......     23,507       *        1,000       *
    Alan E. Smith.................     45,384       *       20,000       *
    G. Jan van Heek (4)...........     50,201       *        1,700       *
    Peter Wirth...................     40,447       *        1,200       *
    Constantine E.
      Anagnostopoulos.............     15,168       *            0       *
    Douglas A. Berthiaume (5).....     82,115       *            0       *
    Henry E. Blair................     21,911       *       21,000       *
    Robert J. Carpenter (6).......     31,213       *            0       *
    Charles L. Cooney (7).........     24,829       *            0       *
    Henry R. Lewis................     12,057       *            0       *
    All current officers and
      directors as a group (15
      people) (8).................  1,409,565     4.9       77,400       *
</TABLE>

- ------------------------

    (1) The shares listed include the following stock options exercisable within
       60 days of February 29, 2000:

<TABLE>
<CAPTION>
                                      GENZ            GZMO            GZSP            GZTR            GZTC
                                  STOCK OPTIONS   STOCK OPTIONS   STOCK OPTIONS   STOCK OPTIONS   STOCK OPTIONS
                                  -------------   -------------   -------------   -------------   -------------
    <S>                           <C>             <C>             <C>             <C>             <C>
    Henri A. Termeer............      518,240         52,080         31,500          174,939         23,000
    Earl M. Collier, Jr.........       78,454          6,684         31,500           21,135             --
    Alan E. Smith...............      128,818         17,618          3,900           38,810         20,000
    G. Jan van Heek.............      117,795          6,350          1,920           39,072          1,200
    Peter Wirth.................      147,119         20,442          1,920           37,463          1,200
    Constantine E.
      Anagnostopoulos...........       31,000          2,700             --           14,028             --
    Douglas A. Berthiaume.......       25,600          6,638             --           17,827             --
</TABLE>

                                       6
<PAGE>

<TABLE>
<CAPTION>
                                      GENZ            GZMO            GZSP            GZTR            GZTC
                                  STOCK OPTIONS   STOCK OPTIONS   STOCK OPTIONS   STOCK OPTIONS   STOCK OPTIONS
                                  -------------   -------------   -------------   -------------   -------------
    <S>                           <C>             <C>             <C>             <C>             <C>
    Henry E. Blair..............       25,600          6,638             --           17,827         20,000
    Robert J. Carpenter.........       18,400          2,700             --           13,208             --
    Charles L. Cooney...........        6,000          2,700             --           13,488             --
    Henry R. Lewis..............       32,000          2,700             --           11,024             --
    All current officers and
      directors as a group (15
      people)...................    1,362,430        151,904         78,710          469,600         65,400
</TABLE>

    The shares listed in this footnote for Mr. van Heek and for all current
    officers and directors as a group include 31,209 shares of GENZ Stock and
    2,043 shares of GZTR Stock subject to stock options held by Mr. van Heek's
    wife. Mr. van Heek disclaims beneficial ownership of shares held by his
    wife.

    (2) The stock beneficially owned by Mr. Termeer includes:

<TABLE>
<CAPTION>
                                                GENZ STOCK   GZMO STOCK   GZSP STOCK   GZTR STOCK
                                                ----------   ----------   ----------   ----------
    <S>                                         <C>          <C>          <C>          <C>
    - shares held by his wife.................    1,123         120          201         6,900
    - shares held in a trust..................      500          --           --         8,649
</TABLE>

    The shares held in trust are for the benefit of Mr. Termeer's son.
    Mr. Termeer disclaims beneficial ownership of all shares held by his wife
    and the trust.

    (3) Mr. Collier's wife owns 9,000 shares of GZSP Stock. Mr. Collier
       disclaims beneficial ownership of all shares held by his wife.

    (4) Mr. van Heek's wife owns 1,089 shares of GENZ Stock, 42 shares of GZMO
       Stock, 168 shares of GZSP Stock and 637 shares of GZTR Stock. Mr. van
       Heek disclaims beneficial ownership of all shares held by his wife.

    (5) Mr. Berthiaume's wife owns 2,000 shares of GENZ Stock, 216 shares of
       GZMO Stock, 358 shares of GZSP Stock and 1,560 shares of GZTR Stock.
       Mr. Berthiaume disclaims beneficial ownership of all shares held by his
       wife.

    (6) Mr. Carpenter's wife owns 348 shares of GENZ Stock, 41 shares of GZMO
       Stock, 62 shares of GZSP Stock, and 44 shares of GZTR Stock.
       Mr. Carpenter disclaims beneficial ownership of all shares held by his
       wife.

    (7) The stock beneficially owned by Dr. Cooney includes:

<TABLE>
<CAPTION>
                                                GENZ STOCK   GZMO STOCK   GZSP STOCK   GZTR STOCK
                                                ----------   ----------   ----------   ----------
    <S>                                         <C>          <C>          <C>          <C>
    - held jointly with his wife..............    8,910        1,732        2,763        11,329
    - held by his wife........................      120           12           21             3
    - held by his son.........................      320           34           57             9
</TABLE>

    Dr. Cooney disclaims beneficial ownership of all shares held individually by
his wife and by his son.

    (8) In addition to the shares listed in footnotes 1 through 7 above, the
       shares listed include the following:

<TABLE>
<CAPTION>
                                                GENZ STOCK   GZMO STOCK   GZSP STOCK   GZTR STOCK
                                                ----------   ----------   ----------   ----------
    <S>                                         <C>          <C>          <C>          <C>
    - shares held jointly with the spouse of
      an officer                                     --          71           --           --
    - shares held by the son of an officer        2,757         297          493          242
</TABLE>

                             ELECTION OF DIRECTORS

    We currently have seven directors. Our board has decided to change the
number of directors to six. Our charter divides the board of directors into
three classes, with each class being as equal in size as

                                       7
<PAGE>
possible. Each class of directors is elected for a three-year term. Mr. Lewis,
whose current term as a director expires at the annual meeting, has decided to
retire from the board. We are actively looking for a new board member to replace
Mr. Lewis.

    Mr. Termeer has been nominated for re-election to a term of office expiring
in 2003. Mr. Termeer has agreed to serve as a director if he is elected. If for
some reason Mr. Termeer is unable to serve, the board will propose a substitute
nominee and the proxies will vote to approve the election of the substitute
nominee. The following biography gives you information about Mr. Termeer
followed by biographies of the directors who are continuing in office.

HENRI A. TERMEER, director since 1983

    Mr. Termeer, 54, has served as President of Genzyme since October 1983,
Chief Executive Officer since December 1985 and Chairman of the Board since
May 1988. For ten years prior to joining Genzyme, Mr. Termeer worked for Baxter
Travenol Laboratories, Inc., a manufacturer of human health care products.
Mr. Termeer is also a director of ABIOMED, Inc., AutoImmune Inc.,
Diacrin, Inc., GelTex Pharmaceuticals, Inc. and Genzyme Transgenics, and a
trustee of Hambrecht & Quist Healthcare Investors and of Hambrecht & Quist Life
Sciences Investors.

                         DIRECTORS CONTINUING IN OFFICE

    The following directors were elected at our 1998 annual meeting for terms
ending in 2001:

DOUGLAS A. BERTHIAUME, director since 1988

    Mr. Berthiaume, 51, is Chairman, President and Chief Executive Officer of
Waters Corporation, a high technology manufacturer of products used for analysis
and purification. From November 1990 to August 1994, he was President of the
Waters Division of Millipore Corporation.

HENRY E. BLAIR, director since 1981

    Mr. Blair, 56, is the Chairman and Chief Executive Officer of Dyax Corp., a
privately held bioseparation, pharmaceutical discovery and development company,
and a consultant to several companies, including Genzyme. Prior to
January 1990, Mr. Blair was Senior Vice President, Scientific Affairs of
Genzyme. Before joining Genzyme in 1981, he was Associate Director of the New
England Enzyme Center at Tufts University School of Medicine. Mr. Blair is also
a director of Genzyme Transgenics and Celtrix Pharmaceuticals, Inc.

    The following directors were elected at our 1999 annual meeting for terms
ending in 2002:

CONSTANTINE E. ANAGNOSTOPOULOS, director since 1986

Dr. Anagnostopoulos, 77, is Managing General Partner of Gateway Associates,
which is the general partner of Gateway Venture Partners III, L.P., a venture
capital partnership. He is a retired corporate executive of Monsanto Company.

ROBERT J. CARPENTER, director since 1994

    Mr. Carpenter, 55, is Chairman of GelTex Pharmaceuticals, Inc., a publicly
held pharmaceutical development company which he co-founded in November 1991 and
where he served as President and Chief Executive Officer until May 1993. He was
President and Chief Executive Officer of VacTex, Inc., a privately held
biotechnology company which he co-founded, from November 1995 until its
acquisition by Aquila Biopharmaceuticals, Inc. in April 1998. Mr. Carpenter was
Chairman of the Board, President and Chief Executive Officer of Integrated
Genetics, Inc., a biotechnology company that merged with us in 1989. Following
the merger and until 1991, Mr. Carpenter was Executive Vice President of
Genzyme, and Chief Executive Officer and Chairman of the Board of IG
Laboratories, Inc. He is also a director of Aquila Biopharmaceuticals.

                                       8
<PAGE>
CHARLES L. COONEY, director since 1983

    Dr. Cooney, 55, is a Professor of Chemical and Biochemical Engineering and
Co-Director of the Program on the Pharmaceutical Industry at Massachusetts
Institute of Technology. Dr. Cooney joined the MIT faculty as an Assistant
Professor in 1970 and became a Professor in 1982. Dr. Cooney is a director of
CUNO, Inc., a high technology manufacturer of filtration products for
separation, clarification and purification of liquids and gases. He is also a
principal of BioInformation Associates, Inc., a consulting company.
                            ------------------------

    The board of directors held nine meetings during 1999, and each director
attended at least 75% of all meetings of the board and all committees of the
board on which he served, except for Dr. Anagnostopoulos, who attended 67% of
the audit committee meetings and Mr. Lewis, who attended 67% of all board
meetings and 67% of the audit committee meetings. The board has audit and
compensation committees, but does not have a nominating committee.

    The audit committee held three meetings in 1999. Current members are
Messrs. Lewis (chairman), Berthiaume, Carpenter and Dr. Anagnostopoulos. The
purpose of the committee is to ensure that the financial information provided to
our stockholders and others is reliable and that the systems of control that we
have established effectively safeguard our assets. The committee reviews the
general scope and results of our annual audit, the fee charged by our
independent accountants and issues relating to internal control systems.

    The compensation committee held six meetings in 1999. Current members are
Drs. Cooney (chairman) and Anagnostopoulos, and Messrs. Berthiaume and Lewis.
The committee determines the compensation to be paid to all executive officers,
including the chief executive officer, and administers our equity incentive
plans.

                             DIRECTOR COMPENSATION

    Employee directors do not receive any additional compensation for their
service on the board of directors. Non-employee directors receive a quarterly
retainer of $6,250. Under our director deferred compensation plan, each director
can choose to defer his retainer fee:

    - in exchange for cash or a combination of cash and stock;

    - into stock accounts allocated to GENZ Stock, GZMO Stock, GZSP Stock and/or
      GZTR Stock; and

    - until his service as a director ends or until a specified date.

    As of March 31, 2000, one of the six eligible directors was participating in
the deferred compensation plan.

    Directors also receive stock option grants for each year (or partial year)
served on the board. Grants are made when a director is elected or re-elected to
the board. The terms of these grants include:

    - 4,000 shares each of GENZ, GZMO, GZSP and GZTR Stock for each year of a
      director's term of office;

    - an exercise price equal to the closing price of each series of stock on
      the date of grant;

    - 4,000 shares become exercisable on the date of each annual meeting
      following the date of grant; and

    - each grant has a term of ten years.

                                       9
<PAGE>
    Mr. Blair has provided consulting services to us since 1990. Mr. Blair's
agreement requires a minimum of 25 days of consulting services during the year.
He receives an annual fee of $50,000. We paid Mr. Blair $36,058 in 1999 under
this agreement.

    Dr. Cooney has provided consulting services to us since 1983. Dr. Cooney's
agreement covers 15 days of consulting services during the year for an annual
fee of $30,000. For each day he works in excess of 15 days he will be paid
$2,000 per day or $250 per hour. We paid Dr. Cooney $30,000 in 1999.

    Mr. Carpenter entered into a consulting contract with us in 1998.
Mr. Carpenter is paid $2,000 per day, and for partial days at a rate of $250 per
hour. Mr. Carpenter received no payment for services in 1999.

                             EXECUTIVE COMPENSATION

COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

    Our executive compensation program is designed to attract, reward and
motivate executive officers who contribute to our long-term success. We also
seek to align executive compensation with the achievement of business objectives
and individual and corporate performance.

    There are three elements to our executive compensation program:

    - base salary;

    - annual incentive bonuses; and

    - stock option grants.

    For 1999, we sought to achieve a total compensation package for each officer
that is between the 40(th) and 60(th) percentile (and at approximately the
55(th) percentile for Mr. Termeer) of a blended market rate of total
compensation paid to officers in comparable positions at other companies in the
pharmaceutical and biotechnology industries. The blended market rate is weighted
40% toward large biotechnology companies and 60% toward pharmaceutical companies
( 50/50 in the case of Mr. Termeer). We believe this is an appropriate measure
of cash compensation because we are regarded in the employment market as a
growing small pharmaceutical company.

    BASE SALARY.  For 1999, Mr. Termeer recommended merit increases and base
salary amounts for each officer other than himself based on his assessment of
each officer's individual performance. We approved his recommendations after
reviewing an analysis of compensation data gathered from two surveys prepared by
independent compensation consultants. These surveys focused on cash compensation
compiled for the biotechnology and pharmaceutical industries. Genzyme was one of
the companies included in each survey. These surveys were used to establish the
blended market rates used in our total compensation package.

    We did not seek to set each officer's salary at the same percentile within
the established range. We evaluated Mr. Termeer's recommendation regarding each
officer's base salary in light of the range established for that officer's
position, taking into account the officer's tenure and our subjective assessment
of individual performance. For 1999, base salaries ranged from the first to the
fourth quartile of the ranges developed from the blended survey data.

    INCENTIVE BONUSES.  A significant portion of the direct pay of officers
consists of annual incentive bonuses. The bonus targets are closely tied to
performance measures, at both the corporate level and at individual areas of
responsibility. We established a bonus target for each officer prior to the
beginning of 1999 using the same survey data considered in setting base
salaries. Mr. Termeer recommended the bonus targets for all officers other than
himself and we evaluated and approved the targets.

                                       10
<PAGE>
    The bonus targets included both an individual performance component and a
corporate performance component for all officers. The individual performance
component was payable at the discretion of Mr. Termeer based on his evaluation
of each officer's performance for the year. The corporate performance component
was payable at our discretion based on the extent to which Genzyme achieved the
operating income goals approved by the board of directors in connection with
setting the 1999 annual budget. For each 2% reduction in meeting these goals, we
would decrease the corporate bonus by 5%. If Genzyme did not achieve at least
86% of the established operating income goals for 1999, then we would not pay
any corporate bonus.

    The 1999 combined bonus targets represented from 52% to 80% of base salary.
The amount payable based on corporate performance represented 30% to 51% of the
total bonus payable. For 1999, Genzyme achieved 96% of the total operating
income goals established in the 1999 budget. As a result, we awarded each
officer 90% of his or her targeted corporate bonus.

    STOCK OPTIONS.  We have established guidelines to limit the total number of
options that may be granted in a fiscal year to a stated percentage of shares
outstanding. Annual option awards for GENZ Stock, GZMO Stock and GZTR Stock were
made in May 1999 to all qualified employees of the company, excluding the
executive officers. In January 1999, we granted stock options to officers under
a new premium long-term equity incentive plan. This program uses premium-priced
stock options to meet our objectives of retaining executives and providing them
with a long-term incentive to achieve superior increases in shareholder value.
The number of options granted to each officer was based on survey data with
respect to comparable positions in other biotechnology and pharmaceutical
companies. The following range of option grants were made to officers under the
premium option program:

<TABLE>
<CAPTION>
                                                                  PREMIUM TO MARKET PRICE
                                        RANGE OF SHARES GRANTED      ON DATE OF GRANT
                                        -----------------------   -----------------------
<S>                                     <C>                       <C>
GENZ Stock............................          27,400-116,090               20%
GZMO Stock............................            8,694-36,835              100%
GZTR Stock............................            8,694-36,835              100%
</TABLE>

    After the formation of Genzyme Surgical Products in June 1999, in
August 1999 we made stock option awards for GZSP Stock to officers, at the same
time that GZSP Stock option awards were made to employees of Genzyme Surgical
Products and other qualified employees, most of whom did not receive stock
option grants at the time of the annual option grant in May 1999. We granted
options to officers in a range of 4,750 to 157,500 shares of GZSP Stock. We
determined the size of each officer's award based on an overall dilution target
for all option grants for GZSP Stock plus each officer's level of involvement in
Genzyme Surgical Products' business. Mr. Collier's grant was based on an
ownership target of 1%.

    In May 1999, we accelerated the exercisability of GENZ Stock options granted
to each of the officers in 1995 under a long-term incentive program, so that the
options became exercisable immediately. As an incentive to tie performance to
increasing shareholder value, the program provided for this acceleration at our
discretion if certain target stock prices were achieved over a 90-day period
from April 1, 1998 through March 31, 1999.

    MR. TERMEER'S COMPENSATION.  In fixing Mr. Termeer's base salary for 1999,
we considered chief executive officer compensation data contained in the same
surveys of biotechnology and pharmaceutical companies used in setting the base
salaries for the other officers. We fixed Mr. Termeer's 1999 base salary at the
55(th) percentile of the range established by the survey data based on the same
factors considered in setting the base salaries for the other officers. In
addition, we considered several corporate performance measures from 1998:

    - consolidated revenues increased 17% to $709.3 million;

    - consolidated net income increased 59% to $62.6 million;

                                       11
<PAGE>
    - sales of Cerezyme-Registered Trademark- enzyme and
      Ceredase-Registered Trademark- enzyme reached a record $411.1 million, a
      24% increase;

    - we received FDA marketing approval for Renagel-Registered Trademark-
      capsules in November;

    - we received FDA marketing approval for Thyrogen-Registered Trademark-
      hormone in December;

    - sales of Carticel-Registered Trademark- chondrocytes increased 66%
      worldwide and 82% in the U.S.; and

    - in November, GZMO Stock began trading on Nasdaq following a distribution
      of GZMO Stock to GENZ stockholders.

    We believe that a significant portion of Mr. Termeer's cash compensation
should be tied to performance. Therefore, we set Mr. Termeer's 1999 combined
bonus target at 100% of his base salary. Approximately 40% of Mr. Termeer's
bonus target was payable based on individual performance and 60% was payable
based on corporate performance. Mr. Termeer received 90% of his targeted
corporate bonus. We awarded Mr. Termeer 100% of his targeted individual
performance bonus based on several achievements during the year, including:

    - creation of Genzyme Surgical Products, and distribution of GZSP Stock to
      GENZ stockholders in June 1999;

    - completion of a phase III clinical trial to evaluate the use of
      Fabrazyme-TM- enzyme replacement therapy to treat patients with Fabry
      disease;

    - European approval for Sepra Film-Registered Trademark- bioresorbable
      membrane for use in cardiac surgery;

    - a collaboration with researchers at Beth Israel Deaconess Medical Center
      in Boston to develop a treatment for cystic fibrosis based on a
      formulation designed to correct the lipid imbalance in cystic fibrosis
      patients to alleviate symptoms of the disease;

    - a collaboration with researchers at Mt. Sinai Medical Center to develop a
      therapy for Niemann-Pick disease;

    - completion of a phase III clinical trial of ATIII for the control of blood
      clotting;

    - establishment of a pre-clinical research program for pemphigus vulgaris, a
      fatal autoimmune disorder, through the acquisition of Peptimmune, Inc.;

    - a collaboration with Skye PharmaTech, Inc. for a point-of-care stroke
      diagnostic product;

    - an agreement to market Focal, Inc.'s surgical sealants in North America;
      and

    - a collaboration with Genovo, Inc. to develop gene therapy treatments for
      lysosomal storage diseases.

    In January 1999, we granted Mr. Termeer options to purchase 232,901 shares
of GENZ Stock, 73,899 shares of GZMO Stock and 73,899 shares of GZTR Stock under
the long-term premium option program based on the same analysis used for
granting premium options to the other officers. In May 1999 we accelerated the
exercisability of options to purchase 56,820 shares of GENZ Stock that were
granted to Mr. Termeer in 1995 under the same long-term program considered for
the other officers. In August 1999, we granted Mr. Termeer options to purchase
157,500 shares of GZSP Stock based on an ownership target of 1%.

    TAX LAW LIMITS ON EXECUTIVE COMPENSATION.  Section 162(m) of the Internal
Revenue Code limits the tax deduction available to Genzyme for compensation paid
to the chief executive officer and the other four most highly paid officers in
excess of $1,000,000 in any fiscal year. Certain performance based compensation
that has been approved by stockholders is not subject to the limit. Our
stockholders have approved an amendment to the 1990 Equity Plan designed to
maximize the deductibility of certain awards under that

                                       12
<PAGE>
plan. We reserve the authority to award compensation that is not fully
deductible under the statute if such an award is consistent with our
compensation policies and is in the best interests of the company and its
stockholders.

                                          By the Compensation Committee,

                                          CHARLES L. COONEY, CHAIRMAN
                                          CONSTANTINE E. ANAGNOSTOPOULOS
                                          DOUGLAS A. BERTHIAUME
                                          HENRY R. LEWIS

                                       13
<PAGE>
                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                               LONG-TERM
                                                                              COMPENSATION
                                                                                 AWARDS
                                                                         SECURITIES UNDERLYING
                                          ANNUAL                               OPTIONS(#)                          ALL OTHER
                                       COMPENSATION                  ------------------------------               COMPENSATION
NAME AND                           --------------------     GENZ       GZMO       GZSP       GZTR       GZTC     --------------
PRINCIPAL POSITION        YEAR     SALARY($)   BONUS($)    STOCK      STOCK      STOCK      STOCK      STOCK         ($)(1)
- ----------------------  --------   ---------   --------   --------   --------   --------   --------   --------   --------------
<S>                     <C>        <C>         <C>        <C>        <C>        <C>        <C>        <C>        <C>
Henri A. Termeer......    1999      850,000    786,250    232,901     73,899    157,500     73,899        --         18,504
  Chief Executive         1998      803,223    698,670     72,800     31,200         --     31,200     9,000         16,932
  Officer                 1997      688,697    526,397     78,000     66,000         --     52,000     3,000         17,742

Earl M. Collier,          1999      365,000    201,000     92,115     29,228    157,500     29,228        --          2,000
  Jr..................    1998      356,539    170,000     21,835      5,459         --      5,459        --          3,296
  Executive Vice          1997      296,635    100,000     84,987      7,500         --     39,918        --          1,904
  President

Alan E. Smith.........    1999      330,000    172,500     83,282     26,425     19,500     26,425        --          2,000
  Senior Vice             1998      317,000    175,000     40,269      6,544         --      6,544        --          2,500
  President,              1997      285,500    127,050     13,169     25,000         --      6,585     6,000          2,116
  Research; Chief
  Scientific Officer

G. Jan van Heek.......    1999      350,000    220,000     88,330     28,027      9,600     28,027        --          2,000
  Executive Vice          1998      330,154    225,000     16,189      4,625         --      9,251     2,000          2,500
  President               1997      287,860    153,915     13,169      7,500         --      6,585        --          1,367

Peter Wirth...........    1999      460,000    221,000    116,090     36,835      9,600     36,835        --          2,000
  Executive Vice          1998      445,462    225,000     23,804     13,602         --      6,801     2,000          2,500
  President; Chief        1997      401,564    169,400     27,205     25,000         --     13,602        --          2,008
  Legal Officer
</TABLE>

- ------------------------

(1) Amounts consist of Genzyme contributions under our retirement savings plan,
    a 401(k) plan. For Mr. Termeer, the reported amounts also include the
    following insurance premiums we paid for life and disability insurance
    benefits:

<TABLE>
<S>                                                           <C>
1999........................................................  $16,504
1998........................................................  $14,432
1997........................................................  $15,741
</TABLE>

                                       14
<PAGE>
                       OPTION GRANTS IN LAST FISCAL YEAR

<TABLE>
<CAPTION>
                                                       INDIVIDUAL GRANTS
                                     -----------------------------------------------------
                                                     % OF TOTAL
                                       NUMBER OF      OPTIONS                                   POTENTIAL REALIZABLE VALUE AT
                                      SECURITIES     GRANTED TO   EXERCISE OR                   ASSUMED ANNUAL RATES OF STOCK
                                      UNDERLYING     EMPLOYEES    BASE PRICE                 PRICE APPRECIATION FOR OPTION TERM
                                        OPTIONS      IN FISCAL     ($/SHARE)    EXPIRATION   -----------------------------------
NAME                                 GRANTED(#)(1)      1999          (1)          DATE         5%($)(2)            10%($)(2)
- ----                                 -------------   ----------   -----------   ----------   --------------       --------------
<S>                                  <C>             <C>          <C>           <C>          <C>                  <C>
Henri A. Termeer
  GENZ Stock.......................     232,901          8.03        58.88       01/25/09        4,900,809           15,925,954
  GZMO Stock.......................      73,899         12.00         5.38       01/25/09          (73,717)             117,941
  GZSP Stock.......................     157,500          5.25         6.69       08/26/09          662,452            1,678,785
  GZTR Stock.......................      73,899          7.20         7.75       01/25/09         (106,269)             170,023

Earl M. Collier, Jr.
  GENZ Stock.......................      92,115          3.17        58.88       01/25/09        1,938,326            6,298,896
  GZMO Stock.......................      29,228          4.75         5.38       01/25/09          (29,156)              46,647
  GZSP Stock.......................     157,500          5.25         6.69       08/26/09          662,452            1,678,785
  GZTR Stock.......................      29,228          2.85         7.75       01/25/09          (42,031)              67,246

Alan E. Smith
  GENZ Stock.......................      83,282          2.87        58.88       01/25/09        1,752,458            5,694,889
  GZMO Stock.......................      26,425          4.29         5.38       01/25/09          (26,360)              42,174
  GZSP Stock.......................      19,500          0.65         6.69       08/26/09           82,018              207,850
  GZTR Stock.......................      26,425          2.57         7.75       01/25/09          (38,000)              60,797

G. Jan van Heek
  GENZ Stock.......................      88,330          3.04        58.88       01/25/09        1,858,680            6,040,075
  GZMO Stock.......................      28,027          4.55         5.38       01/25/09          (27,958)              44,731
  GZSP Stock.......................       9,600          0.32         6.69       08/26/09           40,378              102,326
  GZTR Stock.......................      28,027          2.73         7.75       01/25/09          (40,304)              64,483

Peter Wirth
  GENZ Stock.......................     116,090          4.00        58.88       01/25/09        2,442,819            7,938,325
  GZMO Stock.......................      36,835          5.98         5.38       01/25/09          (36,744)              58,788
  GZSP Stock.......................       9,600          0.32         6.69       08/26/09           40,378              102,326
  GZTR Stock.......................      36,835          3.59         7.75       01/25/09          (52,970)              84,748

All Genzyme stockholders (3)
  GENZ Stock.......................          --            --        58.88             --    3,139,283,432        7,923,961,037
  GZMO Stock.......................          --            --         5.38             --       45,830,041          115,589,040
  GZSP Stock.......................          --            --         6.69             --       62,538,274          158,053,976
  GZTR Stock.......................          --            --         7.75             --      139,224,350          351,484,426
</TABLE>

- --------------------------

(1) Options were granted under the 1990 Equity Incentive Plan and have ten year
    terms. These options were granted at:

    - 120% of fair market value on the date of grant for GENZ Stock;

    - 200% of fair market value on the date of grant for each of GZMO Stock and
      GZTR Stock; and

    - 100% of fair market value on the date of grant for GZSP Stock.

    The GENZ, GZMO and GZTR stock options vest in one-third increments on each
    of January 25, 2001, 2002 and 2003. The GZSP Stock options are exercisable
    20% on the date of grant and an additional 20% of the shares will vest
    annually over the next four years on the anniversary of the date of grant.

(2) The dollar amounts under these columns are the result of calculations at the
    5% and 10% rates set by the SEC and are not intended to forecast future
    appreciation, if any, in the price of the securities. No gain is possible
    without an increase in the price of the underlying stock, which will benefit
    all stockholders. In order to realize the

                                       15
<PAGE>
    potential values in the 5% and 10% columns of this table, the trading price
    of the stocks would have to be approximately 63% and 159% above the
    respective exercise prices for each option, or:

<TABLE>
<CAPTION>
                             OPTION GRANT    63% PRICE   159% PRICE
                            EXERCISE PRICE   INCREASE     INCREASE
                            --------------   ---------   ----------
<S>        <C>              <C>              <C>         <C>
- -          GENZ Stock           $58.88        $95.97       $152.50
- -          GZMO Stock           $ 5.38        $ 8.77       $ 13.93
- -          GZSP Stock           $ 6.69        $10.90       $ 17.33
- -          GZTR Stock           $ 7.75        $12.63       $ 20.07
</TABLE>

(3) The amounts shown for all our stockholders reflect the potential value if
    the GENZ, GZMO, GZSP or GZTR Stocks appreciate at the rates shown over the
    term of the options, if stockholders bought the shares in 1999 at the listed
    option exercise prices.

                                       16
<PAGE>
              AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND
                         FISCAL YEAR-END OPTION VALUES

<TABLE>
<CAPTION>
                                                                 NUMBER OF SECURITIES          VALUE OF UNEXERCISED
                                                                UNDERLYING UNEXERCISED             IN-THE-MONEY
                                  SHARES                              OPTIONS AT                    OPTIONS AT
                                ACQUIRED ON       VALUE          DECEMBER 31, 1999(#)          DECEMBER 31, 1999($)
NAME                            EXERCISE(#)   REALIZED($)(1)   EXERCISABLE/UNEXERCISABLE   EXERCISABLE/UNEXERCISABLE (2)
- ----                            -----------   --------------   -------------------------   -----------------------------
<S>                             <C>           <C>              <C>                         <C>
Henri A. Termeer
  GENZ Stock..................    460,000      $20,961,210             518,240/466,781        $12,531,930/$6,029,888
  GZMO Stock..................         --               --              52,080/119,019                     0/120,012
  GZSP Stock..................         --               --              31,500/126,000                           0/0
  GZTR Stock..................         --               --             150,180/173,474                           0/0
  GZTC Stock..................         --               --                23,000/5,000                137,250/16,563

Earl M. Collier, Jr.
  GENZ Stock..................         --               --              72,454/126,483           $1,253,951/$587,339
  GZMO Stock..................         --               --                6,684/35,503                      0/47,466
  GZSP Stock..................         --               --              31,500/126,000                           0/0
  GZTR Stock..................         --               --               18,135/56,470                           0/0
  GZTC Stock..................         --               --                         0/0                         --/--

Alan E. Smith
  GENZ Stock..................     59,490      $ 2,301,916             128,818/165,430         $2,793,785/$1,892,497
  GZMO Stock..................         --               --               17,618/40,351                      0/42,914
  GZSP Stock..................         --               --                3,900/15,600                           0/0
  GZTR Stock..................         --               --               30,749/47,338                           0/0
  GZTC Stock..................         --               --                    20,000/0                    100,000/--

G. Jan van Heek
  GENZ Stock..................         --               --              86,586/156,030         $1,844,160/$1,842,399
  GZMO Stock..................         --               --                6,350/33,802                      0/45,516
  GZSP Stock..................         --               --                 1,920/7,680                           0/0
  GZTR Stock..................         --               --               31,832/59,453                           0/0
  GZTC Stock..................         --               --                   800/1,200                           0/0

Peter Wirth
  GENZ Stock..................         --               --             147,119/177,974         $2,623,916/$1,082,651
  GZMO Stock..................         --               --               20,442/54,995                      0/59,820
  GZSP Stock..................         --               --                 1,920/7,680                           0/0
  GZTR Stock..................         --               --               37,463/72,097                           0/0
  GZTC Stock..................         --               --                   800/1,200                           0/0
</TABLE>

- ------------------------

(1) This number is calculated by subtracting the option exercise price from
    either the closing price of the stock on the date of exercise or the actual
    sale price of the stock, then multiplying that number by the number of
    shares exercised. The amounts in this column may not represent amounts
    actually realized by the officer.

(2) This number is calculated by subtracting the option exercise price from the
    closing price of the underlying common stock on December 31, 1999, then
    multiplying that number by the number of shares under the option. The
    closing prices on December 31, 1999 were:

    -  GENZ Stock, $45.50;

    -  GZMO Stock, $7.00;

                                       17
<PAGE>
    -  GZSP Stock, $5.81;

    -  GZTR Stock, $2.88; and

    -  GZTC Stock, $12.63.

EXECUTIVE EMPLOYMENT AGREEMENTS

    Mr. Termeer has an employment agreement that renews automatically each
January 1 for an additional one year period, unless written notice of
non-renewal is given. The agreement provided for an initial base salary in 1990
of $300,000 and is subject to increases approved by the board or the
compensation committee.

    Mr. Wirth has an employment agreement that renews automatically each
January 1 for an additional one year period, unless written notice of
non-renewal is given. The agreement provided for his employment in a half-time
capacity for an initial base salary in 1996 of $225,000. When he became a
full-time employee in October 1996, his base salary increased to $380,000 and is
subject to increases approved by the board or the compensation committee.

    Both agreements provide:

    - certain life and disability insurance benefits;

    - participation in the cash bonus plan;

    - participation in equity incentive plans;

    - a lump sum payment of two times annual salary and bonus and full vesting
      of all rights and options, other than certain performance options, under
      stock or other equity incentive plans in the event that employment is
      terminated without cause;

    - a lump sum severance payment of three times annual salary and bonus if
      employment is terminated by us without cause or by him for good reason
      following a change in control;

    - following termination due to a change in control:

       -- a cash payment equal to the additional retirement benefit that would
          have been earned under any retirement plan as if employment had
          continued for three years;

       -- continuation of the life, accident and health insurance coverage for
          three years, unless comparable benefits are provided by a new
          employer; and

       -- in certain circumstances, legal costs and relocation expenses
          associated with the termination; and

    - customary confidentiality, non-competition and ownership of inventions
      provisions.

EXECUTIVE SEVERANCE AGREEMENTS

    We have severance agreements with all our executive officers other than
Messrs. Termeer and Wirth. Under these agreements, payments will be made under
certain circumstances following a change in control. The agreements provide for:

    - automatic renewal each January 1 unless written notice of non-renewal is
      given;

    - following termination due to a change in control:

       -- a lump sum severance payment of two times annual salary and bonus;

                                       18
<PAGE>
       -- a cash payment equal to the additional retirement benefit which would
          have been earned under our retirement plan if employment had continued
          for two years following the date of termination;

       -- participation in life, accident and health insurance plans for such
          period, unless comparable benefits are provided by a new employer; and

       -- in certain circumstances, legal costs and relocation expenses
          associated with such termination.

                            STOCK PERFORMANCE GRAPHS

    These graphs compare the five year cumulative total stockholder returns for
each of our series of common stock to that of the S&P 500 Composite Index and
the Nasdaq Pharmaceutical Index.

GENZ STOCK (1)

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
          GENZ STOCK  S&P 500  NASDAQ PHARMACEUTICAL INDEX
<S>       <C>         <C>      <C>
12/31/94        $100     $100                         $100
12/31/95        $198     $134                         $183
12/31/96        $138     $161                         $183
12/31/97        $176     $211                         $190
12/31/98        $316     $268                         $243
12/31/99        $289     $440                         $452
</TABLE>

                                       19
<PAGE>
GZMO STOCK (2)

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
          GZMO STOCK  S&P 500  NASDAQ PHARMACEUTICAL INDEX
<S>       <C>         <C>      <C>
11/16/98        $100     $100                         $100
12/31/98         $42     $108                         $119
12/31/99         $90     $178                         $221
</TABLE>

GZSP STOCK (3)

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
          GZSP STOCK  S&P 500  NASDAQ PHARMACEUTICAL INDEX
<S>       <C>         <C>      <C>
6/28/99         $100     $100                         $100
12/31/99        $124     $108                         $172
</TABLE>

                                       20
<PAGE>
GZTR STOCK

EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC

<TABLE>
<CAPTION>
          GZTR STOCK  S&P 500  NASDAQ PHARMACEUTICAL INDEX
<S>       <C>         <C>      <C>
12/31/94        $100     $100                         $100
12/31/95        $423     $134                         $183
12/31/96        $190     $161                         $183
12/31/97        $183     $211                         $190
12/31/98         $60     $268                         $243
12/31/99         $77     $440                         $452
</TABLE>

- ------------------------

(1) All amounts reflect a 2-for-1 split of GENZ Stock on July 25, 1996. We have
    made the following dividends on shares of GENZ Stock:

    -  December 23, 1994, 0.0675 share of GZTR Stock for one share of GENZ
    Stock;

    -  July 22, 1997, 0.03 share of GZTR Stock for one share of GENZ Stock;

    -  November 16, 1998, 0.10805 share of GZMO Stock for one share of GENZ
    Stock; and

    -  June 28, 1999, 0.17901 share of GZSP Stock for one share of GENZ Stock.

The cumulative returns are based on a $100 investment on January 1, 1995, with
all dividends, including the GZMO, GZSP and GZTR Stock dividends, being
reinvested.

(2) GZMO Stock was first publicly traded on November 16, 1998. The cumulative
    returns are calculated based on a $100 investment made on that date, with
    all dividends being reinvested.

(3) GZSP Stock was first publicly traded on June 28, 1999. The cumulative
    returns are calculated based on a $100 investment made on that date, with
    all dividends being reinvested.

                                       21
<PAGE>
                PROPOSAL TO AMEND THE 1990 EQUITY INCENTIVE PLAN

GENERAL

    The purpose of our 1990 Equity Incentive Plan is to:

    - attract and retain key employees and consultants;

    - provide an incentive for them to achieve long-range performance goals; and

    - enable them to participate in our long-term growth.

The plan provides for the grant of both incentive and nonstatutory stock
options, stock appreciation rights, performance shares, restricted stock and
stock units. After March 15, 2000, no incentive stock options may be granted
under the plan.

    As of February 29, 2000, the following shares were authorized and available
to grant under the plan:

<TABLE>
<CAPTION>
                                                        AUTHORIZED       AVAILABLE TO GRANT
                                                        ----------       ------------------
<S>                                                     <C>              <C>
- - GENZ Stock:                                           19,800,000            590,250
- - GZMO Stock:                                            1,500,000            557,272
- - GZSP Stock:                                              500,000              4,750
- - GZTR Stock:                                            3,300,000            437,386
</TABLE>

The shares are subject to adjustment for stock splits, stock dividends and
certain transactions affecting our capital stock. Shares may also be issued
through the assumption or substitution of outstanding grants from an acquired
company without reducing the number of shares available for award. As of
February 29, 2000, approximately 3,800 employees were eligible for grants under
the plan. The closing prices of each of our series of stock on February 29, 2000
as reported by Nasdaq were:

    - GENZ Stock, $57.44;

    - GZMO Stock, $26.69;

    - GZSP Stock, $12.63; and

    - GZTR Stock, $8.44.

ADMINISTRATION AND ELIGIBILITY

    The compensation committee has adopted standards for grants of awards under
the plan relating to all series of stock or any combination of each series to
eligible employees and consultants. The committee also periodically reviews the
standards to determine if the levels of awards appropriately reflect our growth
and the value of our stocks. The committee determines the terms and conditions
of each award, including:

    - who is eligible to receive awards;

    - the form of payment of the exercise price;

    - the number of shares subject to options or other equity rights; and

    - when the shares are exercisable.

    The exercise price of any stock option grant may not be less than the fair
market value of the GENZ, GZMO, GZSP or GZTR Stock, as the case may be, on the
date of grant.

    The standards include a new hire grant matrix and an annual grant matrix.
The new hire grant matrix determines the number of options that may be awarded
to new employees, other than executive officers, when they are hired. The awards
are based on the employee's salary grade at his or her date of hire.

    The annual grant matrix is based on an employee's salary grade plus an
individual performance review for the prior year. An employee must have a rating
of "fully meets expectations" in order to qualify for an annual award. The
senior or executive vice president responsible for a division approves the
performance ratings for each employee in that division. The committee has
delegated to our Senior Vice President,

                                       22
<PAGE>
Human Resources the power to administer the standards and make awards in amounts
consistent with the standards and the recommendations provided by the senior
management.

    As of February 29, 2000, we have granted the following shares under the
plan:

<TABLE>
<CAPTION>
NAME                            GENZ STOCK   GZMO STOCK   GZSP STOCK   GZTR STOCK
- ----                            ----------   ----------   ----------   ----------
<S>                             <C>          <C>          <C>          <C>
Henri A. Termeer..............   1,838,021    171,099      157,500       323,654
Earl M. Collier, Jr...........     198,937     42,187      157,500        74,605
Alan E. Smith.................     459,238     57,969       19,500        78,087
G. Jan van Heek...............     294,616     40,152        9,600        91,285
Peter Wirth...................     325,093     75,437        9,600       109,560
All current executive officers
  as a group (15 persons).....   5,027,669    626,031      466,100     1,157,055
All other employees...........  19,071,252    342,160       32,950     2,624,993
</TABLE>

We have not granted any stock appreciation rights, performance shares,
restricted stock, stock units or other stock-based awards under the plan.

DESCRIPTION OF AMENDMENT TO THE PLAN

    On March 2, 2000 our board of directors approved an amendment to the plan,
subject to stockholder approval, to authorize the increase of 175,000 shares of
GZSP Stock under the plan from 500,000 to 675,000 shares. These shares are in
addition to shares of GENZ Stock, GZMO Stock and GZTR Stock currently available
for issuance.

    IF THE CREATION OF THE GENZYME BIOSURGERY DIVISION IS APPROVED BY
STOCKHOLDERS AT THE SPECIAL MEETING IN JUNE AND IS SUBSEQUENTLY COMPLETED, THE
GZSP STOCK WILL NO LONGER EXIST AND THE ADDITIONAL SHARES OF GZSP STOCK THAT WE
ARE ASKING YOU TO APPROVE HERE WILL NO LONGER BE APPLICABLE AND WILL BE
CANCELLED.

FEDERAL INCOME TAX CONSEQUENCES RELATING TO THE PLAN

    INCENTIVE STOCK OPTIONS.  An optionee does not realize taxable income when
an incentive stock option is granted or exercised. A taxable event occurs when
the shares are disposed of. The tax treatment depends on how long the shares are
held before disposition.

    Incentive stock options can have beneficial tax treatment for an optionee if
certain holding period requirements are met. To qualify for this tax treatment
the shares must be held:

    - two years from the date of grant; and

    - one year from the date of exercise.

    If these holding period requirements are met, then when the shares are
disposed of, the amount realized in excess of the amount paid for the shares is
taxed to the optionee as long-term capital gain and any loss will be a long-term
capital loss. We are not allowed a tax deduction for the amount realized by the
optionee.

    If an optionee disposes of the shares before meeting the one-year and
two-year holding periods, known as a disqualifying disposition, the amount
realized in excess of the amount paid for the shares is taxed to the optionee as
ordinary income. We are allowed a tax deduction for the income realized by an
optionee in a disqualifying disposition.

    NONSTATUTORY STOCK OPTIONS.  An optionee does not realize taxable income
when a nonstatutory option is granted. When the option is exercised, the
optionee will recognize ordinary income in an amount equal to the difference
between the amount paid for the shares and the fair market value of the shares
on the date of exercise. We are allowed a tax deduction for the same amount.
When the shares are disposed of, any additional gain in excess of the market
value of the shares on the date of exercise is treated as

                                       23
<PAGE>
short-term or long-term capital gain or loss. We are not allowed any additional
tax deduction. Capital gain is short-term if the shares have been held one year
or less, and long-term if held more than one year.

                   PROPOSAL TO AMEND AND RESTATE OUR CHARTER

    INFORMATION IN THIS PROXY STATEMENT REGARDING THE PROPOSED AMENDMENT TO OUR
CORPORATE CHARTER IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO THE TEXT OF OUR
CHARTER, AS PROPOSED TO BE AMENDED AND RESTATED, WHICH IS ATTACHED TO THIS PROXY
STATEMENT AS APPENDIX A AND INCORPORATED BY REFERENCE. INFORMATION REGARDING OUR
CURRENT CHARTER IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO THE TEXT OF OUR
CURRENT CHARTER, INCLUDING ALL AMENDMENTS TO DATE, FILED AS EXHIBITS TO OUR MOST
RECENT ANNUAL REPORT ON FORM 10-K.

GENERAL

    Our board of directors has authorized, subject to our stockholders'
approval, an amendment to our charter that would modify the terms applicable to
the GZMO, GZSP and GZTR Stocks. The proposed charter amendment would:

    - modify and make consistent the provisions governing the treatment of
      shares of GZMO, GZSP and GZTR Stock upon a sale of all or substantially
      all of the respective division's assets;

    - add provisions for GZMO Stock and GZTR Stock, consistent with the existing
      provisions governing GZSP Stock, permitting our board of directors to
      exchange all shares of GZMO and/or GZTR Stock for GENZ Stock at no premium
      in the event that a change in federal tax law or regulations results or
      has the potential to result in adverse tax treatment of our tracking stock
      structure;

    - add provisions for GZMO Stock and GZTR Stock, consistent with the existing
      provisions governing GZSP Stock, which, in the event that a change in
      federal tax law or regulations results or has the potential to result in
      adverse tax treatment of our tracking stock structure, would permit:

       -- our stockholders, voting together as a single class, to eliminate
       special voting rights; and

       -- our board of directors to modify or eliminate certain exchange
       provisions;

    - add provisions permitting Genzyme to "spin off" Genzyme Molecular
      Oncology, Genzyme Surgical Products or Genzyme Tissue Repair to the
      holders of that respective business unit's tracking stock; and

    - modify the provisions governing generally the contents of notices to our
      stockholders regarding exchanges of or distributions on our tracking
      stock.

    In considering this charter amendment you should be aware that we intend to
convene a special meeting of Genzyme stockholders in June. At the special
meeting we will ask you to approve the creation of a new series of common stock
to track a new division that we anticipate calling Genzyme Biosurgery. Genzyme
Biosurgery will combine the businesses of Genzyme Surgical Products and Genzyme
Tissue Repair with Biomatrix, Inc., with whom we signed a merger agreement on
March 6, 2000. We will also ask GZSP and GZTR stockholders to approve the
transfer of the Genzyme Surgical Products and Genzyme Tissue Repair assets into
this new division and the conversion of their shares of GZSP and GZTR Stock into
the tracking stock of this new division (which we expect to call GZBX Stock).
The GZBX Stock is expected to have identical terms, rights and preferences to
those of the GZMO, GZSP and GZTR Stock proposed by the amendment described in
this proxy statement.

DESCRIPTION OF THE AMENDMENT

    The following discussion describes the amendments that our board of
directors proposes for adoption. This description is only a summary; you are
encouraged to read the entire text of the proposed amendment and restatement of
our charter contained in Appendix A to this proxy statement.

                                       24
<PAGE>
AMENDMENT TO THE MANDATORY EXCHANGE PROVISIONS

    Under our current charter, if we sell all or substantially all of the assets
of Genzyme Molecular Oncology, Genzyme Surgical Products or Genzyme Tissue
Repair, the division's stockholders are entitled to receive GENZ Stock and/or
cash in exchange for their division stock. The amount of GENZ Stock and/or cash
they receive would be based on the fair market value of their division stock
calculated before announcement of the sale. Specifically, the fair market value
of the division stock, as well as of any GENZ Stock given in exchange, would be
based on the average 20-day closing price of the stock beginning the 30(th)
business day PRIOR to the public announcement of the sale. In the case of a sale
of the assets of Genzyme Molecular Oncology or Genzyme Tissue Repair, the
division's stockholders are entitled to receive shares of GENZ Stock and/or cash
with a fair market value equal to 130% of the fair market value of their
tracking stock. In the case of a sale of Genzyme Surgical Products assets, GZSP
stockholders are entitled to receive shares of GENZ Stock and/or cash with a
fair market value equal to 100% of the fair market value of the GZSP Stock.

    The proposed amendment would change this mandatory exchange feature.
Following the sale of all or substantially all of the division's assets, the
division stockholders would instead receive either (1) cash, securities
(excluding Genzyme common stock) and/or other property equal in value to the
after-tax net proceeds of the sale, or (2) shares of GENZ Stock equal in value
to 110% of the average closing price of their division stock during a 10-day
trading period beginning after we publicly announce the estimated net proceeds
from the sale. In particular, the new exchange provision would have the features
described below.

    METHOD AND FORM OF PAYMENT.  Subject to the exceptions described below, our
board of directors would have the option, in its sole discretion, to select one
of the following payment methods:

    - PAYMENT METHOD 1.  A pro rata dividend payment of cash, securities (other
      than Genzyme common stock) or other property to division stockholders in
      an amount equal to the after-tax net proceeds of the sale.

    - PAYMENT METHOD 2.  A redemption of all or a portion of the division's
      outstanding stock. If all of the division's assets were sold, Genzyme
      would redeem all outstanding division stock for cash, securities (other
      than Genzyme common stock) or other property in an amount equal to the
      sale's net proceeds. If substantially all (but not all) of the division's
      assets were sold, Genzyme would redeem a pro rata portion of the
      division's stock in an amount equal to the sale's net proceeds.

    - PAYMENT METHOD 3.  An exchange of each share of division stock for shares
      of GENZ Stock equal to 110% of the average closing price of the division's
      stock. The average closing price of each stock would be calculated during
      the 10-day trading period beginning on the fifth trading day AFTERour
      announcement of the sale's estimated net proceeds.

    The board's decision may be made at any time prior to 20 business days after
the date it announces the estimated net proceeds achieved from the sale. The
redemption or dividend payment under methods 1 and 2 described above could be in
the form of cash, securities or other property, but not Genzyme common stock,
and need not be in the same form as the cash, securities and/or other property
paid by the third party purchasing the division's assets. An exchange under
method 3, on the other hand, could be completed only with GENZ Stock.

    CALCULATION AND VALUATION OF NET PROCEEDS.  To determine the amount of cash,
securities or other property distributable to division stockholders after the
sale of the division's assets, two calculations would be made. First, the net
proceeds of the sale would be computed. Net proceeds would equal the gross
proceeds of the sale, less taxes, transactional costs, liabilities assumed by
another Genzyme division because of the sale, and amounts payable to any
preferred stockholders of the division. Second, the amount of net proceeds
allocable for distribution to the division's stockholders would be calculated.
This amount is the product of the net proceeds multiplied by a fraction. The
fraction equals the outstanding shares of the division divided by the sum of the
outstanding shares of the division plus the shares of the division then
"designated" for the benefit of Genzyme General. Designated shares are
authorized shares

                                       25
<PAGE>
of GZMO, GZSP and GZTR Stock that are not issued and outstanding, but which our
board of directors may issue, sell or distribute without allocating the proceeds
to the division that the series of stock tracks. We create designated shares
when we transfer cash or other assets from Genzyme General to our other
divisions or from other interdivision transactions.

    In establishing a value to the cash, property and/or securities that
comprise the gross proceeds of a sale:

    - cash will be valued at face value;

    - securities will be valued at the average of their intra-day high and low
      trading prices (or if there is no market for the security, at their fair
      value determined by our board of directors) on the date of the sale; and

    - property, other than cash and securities, will be valued at its fair value
      on the date of the sale, as determined by our board of directors.

    Similarly, the value of cash, property and/or securities (other than GENZ
Stock distributed under Payment Method 3) distributed to division stockholders
will be established the same way as of the date of the sale. Interest earned on
any cash net proceeds distributed to division stockholders will be included in
that distribution payment.

    TIMING OF THE PAYMENT.  Our board must announce the estimated net proceeds
of the sale no later than 20 business days after the sale is completed. Within
20 business days following that announcement, our board must choose and announce
which of the three payment methods it will use. Within 60 business days after
the announcement of the payment method selected, Genzyme must complete the
distribution to the division's stockholders.

    EXCEPTIONS FROM THE MANDATORY EXCHANGE PROVISION.  Under our current
charter, there are three types of asset sales that would not trigger a mandatory
payment to division stockholders, namely:

    - a sale of all or substantially all of Genzyme's assets;

    - a transfer of a division's assets to a wholly-owned entity of Genzyme; or

    - a transfer of a division's assets to an entity formed by Genzyme to
      finance the division's programs or products, where Genzyme has an option
      to reacquire those assets or retain or obtain substantial manufacturing or
      marketing rights for products developed by the entity for the benefit of
      the division.

    Under the proposed amendment, the second and third exceptions listed above
would be eliminated and replaced by the following:

    - a sale of a division's assets to an entity controlled, as determined by
      our board of directors, by Genzyme;

    - a sale of a division's assets primarily for equity in a buyer that our
      board of directors determines is engaged primarily in a business similar
      or complementary to that of the division;

    - a distribution to a division's stockholders of Genzyme's equity interest
      (which is allocated entirely to the division) in one or more Genzyme
      subsidiaries that hold all of a division's assets (and only that
      division's assets)--namely, a "spin off" of our ownership interest in the
      division to the stockholders of the division; and

    - a sale of a division's assets conditioned on the affirmative vote of that
      division's stockholders voting as a single class.

AMENDMENTS ADDRESSING CONSEQUENCES OF ADVERSE TAX LAWS

    EXCHANGE DUE TO AN ADVERSE TAX LAW.  Under our current charter, our board of
directors can exchange GZMO, GZSP or GZTR Stock at any time for any combination
of GENZ Stock and/or cash. If it does so,

                                       26
<PAGE>
it must exchange each share of the applicable tracking stock for the number of
shares of GENZ Stock with a fair market value equal to 130% of the fair market
value of the stock being exchanged. An additional term of the GZSP Stock, which
is not currently a term of the GZMO or GZTR Stock, permits our board of
directors to exchange GZSP Stock for GENZ Stock (but not for cash) at 100% of
the GZSP Stock's fair market value if a change in federal tax law or regulations
results or, in the opinion of our counsel, would more likely than not result in
adverse tax treatment of Genzyme's tracking stock structure. Adverse tax laws or
regulations include those that would subject Genzyme or our stockholders to a
tax due to the issuance, receipt or holding of tracking stock, or would cause
the tracking stock in question or GENZ Stock not to be treated solely as Genzyme
stock for tax purposes. The amendment would make the terms of the GZMO and GZTR
Stock consistent with the terms of the GZSP Stock by adding a provision
permitting an exchange of GZMO and GZTR Stock for GENZ Stock, but not for cash,
at 100% of the division stock's fair market value in the event of an adverse tax
law development.

    MODIFICATION OF EXCHANGE RIGHTS UPON A TAX EVENT.  The current terms of the
GZSP Stock provide that, if necessary to avoid adverse tax consequences, our
board can eliminate the right to use cash or any other property that is not
Genzyme stock for effecting a mandatory or optional exchange. Those exchange
rights could be eliminated only if we receive an opinion of counsel stating that
adverse tax consequences would or would be likely to occur unless the rights are
eliminated. There is no comparable provision in the terms of the GZMO or GZTR
Stock. The amendment would make the terms of the GZMO and GZTR Stocks identical
in this regard to the terms of the GZSP Stock allowing our board to eliminate
cash/property exchange rights in response to an adverse tax change. In the case
of the mandatory exchange feature, elimination of the cash exchange right will
result in the new mandatory exchange provision requiring us to exchange the
stock of the division whose assets are being sold into shares of GENZ Stock
based on both stocks' fair market value as of the date of the sale announcement
and at no premium.

    ELIMINATION OF SPECIAL VOTING RIGHTS UPON A TAX EVENT.  The GZMO, GZTR and
GZSP Stocks have special, series-based voting rights. These voting rights
require that a division's stockholders, voting separately as a class, approve:

    - the use by another division of the proceeds from a sale of the division's
      assets, unless fair compensation is provided to the division;

    - the use by another division of the division's properties or assets, unless
      fair compensation is provided to the division;

    - any adverse change in the rights or preferences of the division's stock;
      and

    - any merger where Genzyme common stockholders would own less than 50% of
      the voting power of the surviving company and the holders of any series of
      our stock would not receive the same form of consideration as each other
      series, distributed among them based on the relative market
      capitalizations of the underlying divisions.

If we receive an opinion of counsel stating that these special voting rights
would or would be likely to cause adverse tax consequences, the terms of the
GZSP Stock require only a vote of all series of Genzyme's common stock, voting
together as a single class, to eliminate the GZSP Stock's special series-based
voting rights. Without that provision, Massachusetts law would otherwise require
an additional separate series vote of the GZSP Stock to approve the elimination
of the GZSP Stock's special voting rights. There is currently no comparable
provision in the terms of the GZMO or GZTR Stock.

    The amendment would make the terms of the GZMO and GZTR Stocks identical to
the terms of the GZSP Stock permitting holders of Genzyme common stock, voting
together as one class, to eliminate special series-based voting rights.

OTHER AMENDMENTS

    EXCHANGE TO EFFECT A "SPIN OFF."  The amendment would add a provision to our
charter permitting our board--at any time at which all of a division's assets
(and only that division's assets) are held by a wholly-

                                       27
<PAGE>
owned subsidiary (or subsidiaries) of Genzyme--to redeem all of the division's
outstanding stock in exchange for all of the subsidiary's stock. This type of
transaction is commonly referred to as a "spin off" of a line of business. If
this type of spin off is completed, the division would continue as a separate
corporate entity owned by the former stockholders of the division.

    AMENDMENTS RELATED TO THE CONTENT OF EXCHANGE NOTICES.  Our current charter
specifies information that must be contained in a notice sent to stockholders
when Genzyme intends to effect an exchange of their stock. The amendment would
require that the following additional information be contained in that notice:

    - the total number of shares outstanding of the stock to be exchanged;

    - the total number of shares being exchanged (not only, as under our current
      charter, the number of the holder's shares to be exchanged);

    - the aggregate amount of consideration to be paid to all holders in the
      exchange;

    - a statement, if applicable, that dividends will cease to be paid as of the
      exchange date;

    - the number of shares of the stock to be exchanged for shares issuable
      under outstanding convertible securities, and their conversion prices; and

    - in notices to holders of convertible securities, information regarding the
      effect of the exchange on the stock underlying their convertible
      securities.

    The purpose of modifying the content of notices sent to stockholders in
connection with an exchange is to provide more complete information. Because
this amendment would apply to any notice of exchange effected under the charter,
and is neither specific nor adverse to any particular series, this amendment
will be adopted if approved by all our common stockholders voting as one class,
and is not subject to separate approval by any series.

REASONS FOR THE AMENDMENT

    We are proposing the above-described amendment because we believe it will
improve the marketability of our GZMO, GZSP and GZTR tracking stocks and create
greater operational flexibility by:

    - making it more likely that upon a sale or all or substantially all of a
      division's assets stockholders will receive a distribution that more
      accurately reflects the value assigned to those assets by a third party
      purchaser;

    - permitting us to inform investors that these three tracking stocks have
      been updated to include the terms generally contained in more recently
      introduced tracking stock structures of other companies;

    - making the terms of these three tracking stocks consistent and thereby
      eliminating for investors valuation considerations based solely on a
      comparison of the relative advantages or disadvantages of each division's
      charter provisions; and

    - extending to Genzyme the benefits of an updated and uniform charter for
      these three divisions which will allow us to operate, finance and grow the
      businesses of these divisions more effectively.

    As noted earlier, at a special stockholders meeting that we intend to
convene in June, we will ask you to approve the creation of a new GZBX Stock in
connection with our acquisition of Biomatrix. The GZBX Stock would track a new
division of Genzyme created by the combination of Biomatrix, Genzyme Surgical
Products and Genzyme Tissue Repair. In creating the new division, which we
intend to call Genzyme Biosurgery, we would convert the outstanding shares of
GZSP and GZTR Stock into shares of GZBX Stock. The proposed terms of the GZBX
Stock are meant to be identical to the terms of the GZMO, GZSP and GZTR Stock as
proposed to be amended in this proxy statement. If you approve the creation of
the GZBX Stock, and the GZBX Stock is in fact created, the terms of the GZMO
Stock would be consistent with the terms of the new GZBX Stock only if the
amendment you are being asked to approve in this proxy statement were adopted
and made effective.

                                       28
<PAGE>
    The purpose of eliminating the exception to the mandatory exchange provision
for transfers to financing vehicles set up by Genzyme is that recent accounting
changes have substantially reduced the use of these types of financing vehicles.

    The purpose of the additional exceptions to the mandatory exchange provision
is to:

    - permit the board greater flexibility in effecting a corporate
      restructuring involving the transfer of a division's assets into and/or
      among Genzyme controlled entities or through spin offs;

    - permit us to transfer assets to an entity engaged in a similar or
      complementary business without triggering a mandatory payment to that
      division's stockholders so long as we hold an equity interest in that
      entity--for example, to a joint venture in which we hold an equity
      interest, even if we do not control the joint venture; and

    - permit a division's stockholders to approve an alternative treatment of
      their shares upon a sale of all or substantially all their division's
      assets, without requiring the approval of the entire class of Genzyme
      common stockholders.

    Our board is proposing the amendments to GZMO and GZTR Stock dealing with
the tax law consequences of tracking stock to make the terms of those series
consistent with those of GZSP Stock. The proposed terms are a response to past
Clinton Administration proposals. In 1999, the Clinton Administration proposed
legislation that would have imposed a corporate level tax on issuances of
tracking stock. In February 2000, the Administration proposed legislation that
would tax stockholders upon their receipt of tracking stock from the issuing
corporation in a distribution or recapitalization. Although Congress has not
enacted these proposals into law, if these or similar proposals were enacted
into law or effected through Treasury regulations, Genzyme could be taxed on the
gain realized in future financings in which we sell tracking stock. Also, any
use of our tracking stock to acquire other companies could be taxed. We may also
be taxed if we distribute to stockholders "designated" shares of tracking stock.
In addition, stockholders could be taxed if they receive a distribution of
designated shares of tracking stock or if they receive shares of tracking stock
in exchange for other Genzyme stock. To avoid these or similar adverse tax
consequences, we are seeking your approval of amendments that would permit our
board to:

    - eliminate the specific terms of a tracking stock that would trigger the
      adverse tax consequence, and

    - exchange any or all other series of tracking stock for GENZ Stock with a
      value equal to 100% of the exchanged stock's fair market value

if we receive an opinion of counsel advising us that, unless such action were
taken by our board, our tracking stock structure could result in adverse tax
consequences. Currently, if the board deemed it necessary under such
circumstances to unwind its tracking stock structure we could exchange shares of
GZMO and GZTR Stock for GENZ Stock equal in value to 130% of the GZMO and GZTR
Stocks' respective fair market values. Alternatively, we could offer those
stockholders an exchange on different terms. The amendment would enable us to
avoid incurring the substantial cost and dilution of exchanging the GZMO and
GZTR Stocks at a 30%, or some other, premium to their fair market value in a
situation that arises solely because of an adverse tax development.

    An additional consideration relating to the amendment that would permit our
board to spin off a division's business into a separate corporation is that due
to adverse tax consequences that may be associated with acquiring a company that
has recently done a spin off, a spin off could be used by our Board as a
deterrent measure in response to an unsolicited takeover proposal.

DISSENTERS' APPRAISAL RIGHTS

    Under Massachusetts law, GZMO, GZSP and GZTR stockholders who object to the
proposed amendment will have the right to demand payment from Genzyme for their
shares. Our board of directors has resolved that if stockholders demand payment
for greater than 5% of the outstanding shares of any of these three tracking
stocks, then the proposed amendment as it relates to that series will not be
adopted. However, our board of directors reserves the right to waive this
condition in part or entirely at any time.

                                       29
<PAGE>
    If you exercise your rights of appraisal, you should refer to Chapter 156B
of the General Laws of Massachusetts, sections 86 to 98, inclusive, which set
forth your and Genzyme's rights and duties and the procedures governing the
appraisal of your shares. A copy of those sections of the statute are attached
to this proxy statement as Appendix B.

HOW TO DEMAND PAYMENT FOR AND APPRAISAL OF YOUR SHARES

    If our stockholders approve the proposed amendment to our charter, we intend
to file the amendment with the Secretary of the Commonwealth of Massachusetts as
soon as practicable after the annual meeting. Once the Secretary declares the
amendment effective, holders of GZMO, GZSP and GZTR Stock who objected to the
amendment will be entitled to appraisal rights under Massachusetts law. If you
wish to exercise your appraisal rights, you must strictly adhere to the
procedures set forth in the Massachusetts statute. The following is a summary of
those procedures:

    - You must file a written objection to the charter amendment with Genzyme
      Corporation, One Kendall Square, Cambridge, Massachusetts 02139,
      Attention: Clerk, prior to the annual meeting, stating your intention to
      demand payment for your shares of GZMO, GZSP or GZTR Stock if the
      amendment is approved and made effective. If you file your objection with
      Genzyme prior to the annual meeting, you do not need to vote against the
      amendment. A vote by proxy or in person against the amendment alone does
      not constitute a demand for payment and appraisal.

    - You must not vote in favor of the amendment, otherwise you will have
      waived your rights of appraisal.

    - We will notify you within ten (10) days of the amendment becoming
      effective. You must send us a written demand for payment for your shares
      of GZMO, GZSP or GZTR Stock within twenty (20) days after receiving our
      notice.

    If you have followed the procedures summarized above and the amendment
becomes effective, Genzyme will contact you in order to determine the fair value
of your stock. The "fair value" of your stock will be determined as of the day
before Genzyme stockholders approved adoption of the amendment and will exclude
any value arising from the expectation or effectiveness of the amendment. If
Genzyme and you have not agreed as to the fair value of your stock within fifty
(50) days after you receive our notice that the amendment became effective, both
you and Genzyme will have the right to have the court determine the fair value
by filing a bill in equity in the Superior Court Department of Middlesex County,
Massachusetts no later than four (4) months after the expiration of the
negotiation period. The determination of fair value of, plus any accrued
interest on, the shares as made by the court will be binding on and enforceable
by you and the other stockholders who have properly exercised their appraisal
rights.

    Stockholders considering seeking appraisal of their shares of GZMO, GZSP or
GZTR Stock should note that the fair value of their shares determined under the
Massachusetts statute could be more, the same or less than the market price of
that stock after effectiveness of the amendment. The costs of the appraisal
proceeding may be determined by the court and allocated among the parties as the
court deems equitable in the circumstances. Your appraisal rights are your only
remedy if you object to adoption of the amendment, unless adoption of the
amendment is determined to have been illegal, fraudulent or in breach of our
board's fiduciary duties.

                                       30
<PAGE>
                              CERTAIN TRANSACTIONS

    GELTEX.  In June 1997, Genzyme and GelTex Pharmaceuticals established
RenaGel LLC, a joint venture to complete the development and commercialization
of Renagel-Registered Trademark- capsules. Renagel-Registered Trademark-
capsules are prescribed to control the elevated serum phosphate levels that
cause serious complications in chronic kidney failure patients. Genzyme and
GelTex each hold a 50% ownership interest in RenaGel LLC. Each is funding half
of the joint venture's costs and expenses, and will share equally in the
profits. If either one fails to fund its share of costs and expenses, the profit
sharing interests and the future funding obligations may be proportionately
adjusted. GelTex contributed Renagel-Registered Trademark- capsules and its
underlying patents and technologies to the joint venture. Under the joint
venture agreement, we:

    - purchased 100,000 shares of GelTex common stock at $25.00 per share in
      June 1997. This represents less than 1% ownership in GelTex;

    - made a $15.0 million payment to GelTex in November 1998 when
      Renagel-Registered Trademark- capsules received FDA marketing approval;
      and

    - made a $10.0 milion payment to GelTex in November 1999, one year after
      Renagel-Registered Trademark- capsules received marketing approval.

The joint venture has rights to commercialize Renagel-Registered Trademark-
capsules worldwide, except in Japan and Pacific Rim countries. We will market
and sell products for the joint venture as exclusive distributor. Mr. Carpenter
is chairman of the board of directors and Mr. Termeer is a director of GelTex.

    DYAX.  In March 1996, we entered into two license agreements with Dyax and
Protein Engineering Corporation, a wholly-owned subsidiary of Dyax, for Dyax's
phage display technology. We paid an initial license fee of $53,700 and we pay
annual license maintenance fees of $50,000. We will also make milestone payments
and pay royalties on net sales of diagnostic and therapeutic products
discovered, made or developed using the licensed technology.

    In September 1996, we subleased office and laboratory space in Cambridge,
Massachusetts to Dyax. Current rent under this sublease is $53,943 per month.
Dyax paid approximately $615,000 in sublease fees to us during 1999.

    In October 1998, we entered into a collaboration with Dyax to develop and
commercialize one of Dyax's proprietary compounds for the treatment of chronic
inflammatory diseases. Dyax will fund the first $6 million in development costs,
and the parties will split all subsequent development costs equally. In
connection with that agreement, we made an investment of $3 million in the
convertible preferred stock of Dyax and made a $3 million line of credit
available to help Dyax fund its operations. To date, Dyax has not borrowed any
money under the line of credit. We will make milestone payments to Dyax upon FDA
approval of products that arise out of the collaboration, and we will share
equally with Dyax all profits from the sale of these products.

    Mr. Blair is chairman and chief executive officer of Dyax and each of
Mr. Blair, Dr. Anagnostopoulos and Mr. Lewis are directors of Dyax.

    GDP.  In September 1989, we sponsored Genzyme Development Partners, L.P., a
research and development limited partnership. We entered into a development
contract with the partnership to perform research and development of certain
products based on hyaluronic acid that we refer to as the Sepra products. In
December 1997, we made a $1.5 million capital contribution to the partnership
through Genzyme Development Corporation II, a wholly-owned subsidiary of Genzyme
and the general partner of the partnership. We have the option to purchase all
of the outstanding partnership interests in the partnership for approximately
$26 million in cash, common stock or a combination of both, plus future royalty
payments on the sale of the Sepra products. We can exercise this option during
the 90-day period beginning August 31, 2000. We have funded, and intend to fund
during 2000, the partnership's research and development activities. Mr. Termeer
is the president and a director, and our chief financial officer,

                                       31
<PAGE>
Michael S. Wyzga, is treasurer, of Genzyme Development Corporation II.
Messrs. Termeer and Wyzga receive no compensation from either Genzyme
Development Corporation II or the partnership.

            SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

    Our executive officers and directors are required under Section 16(a) of the
Securities Exchange Act of 1934 to file reports of ownership and changes in
ownership of our securities with the SEC. Based on a review of the copies of
reports furnished to us and written representations that no other reports were
required, we believe that during 1999 our executive officers and directors
complied with all Section 16(a) filing requirements, except that Dr. Richard
Moscicki reported on February 14, 2000 the purchase of 5,000 shares of GZSP
Stock. The report for this purchase was due on August 10, 1999.

                            INDEPENDENT ACCOUNTANTS

    The firm of PricewaterhouseCoopers LLP, independent accountants, audited our
financial statements for the years ending December 31, 1999, 1998 and 1997. Our
board of directors has appointed them to serve as our auditors for the fiscal
year ending December 31, 2000. Representatives of PricewaterhouseCoopers are
expected to attend the annual meeting to answer any questions and will have the
opportunity to make a statement if they wish.

                             STOCKHOLDER PROPOSALS

    To be included in our 2001 annual proxy statement to bring business before
the annual meeting, a shareholder proposal must be received by us in writing no
later than February 25, 2001. Our by-laws permit you to bring business before or
propose director nominations to be considered at an annual meeting. The notice
must contain specified information about you and the proposed business or
nomination. If any stockholder proposal is submitted after March 27, 2001, our
board will be allowed to use its discretionary voting authority when the
proposal is raised at the annual meeting without any discussion of the matter in
the proxy statement. If you are interested in the procedures required to submit
a proposal, please contact Genzyme Corporation, One Kendall Square, Cambridge,
Massachusetts 02139, Attention: Clerk, phone: (617) 252-7500.

                      WHERE YOU CAN FIND MORE INFORMATION

    The following information contained in our 1999 annual report on Form 10-K
filed with the SEC on March 30, 2000 is incorporated by this reference into this
proxy statement:

    - the information in Exhibit 13.1 to our Form 10-K reproducing the text from
      the 1999 Genzyme General Annual Report under the heading "Management's
      Discussion and Analysis of Genzyme General's Financial Condition and
      Results of Operations" and "Genzyme General Combined Financial Statements"
      and notes thereto;

    - the information in Exhibit 13.2 to our Form 10-K reproducing the text from
      the 1999 Genzyme Molecular Oncology Annual Report under the heading
      "Management's Discussion and Analysis of Genzyme Molecular Oncology's
      Financial Condition and Results of Operations" and "Genzyme Molecular
      Oncology Combined Financial Statements" and notes thereto;

    - the information in Exhibit 13.3 to our Form 10-K reproducing the text from
      the 1999 Genzyme Surgical Products Annual Report under the heading
      "Management's Discussion and Analysis of Genzyme Surgical Products'
      Financial Condition and Results of Operations" and "Genzyme Surgical
      Products Combined Financial Statements" and notes thereto;

    - the information in Exhibit 13.4 to our Form 10-K reproducing the text from
      the 1999 Genzyme Tissue Repair Annual Report under the heading
      "Management's Discussion and Analysis of

                                       32
<PAGE>
      Genzyme Tissue Repair's Financial Condition and Results of Operations" and
      "Genzyme Tissue Repair Combined Financial Statements" and notes thereto;

    - the information in Exhibit 13.5 to our Form 10-K reproducing the text from
      the Genzyme General Annual Report under the heading "Management's
      Discussion and Analysis of Genzyme Corporation and Subsidiaries' Financial
      Condition and Results of Operations" and "Genzyme Corporation and
      Subsidiaries' Consolidated Financial Statements" and notes thereto; and

    - the information in our annual report on Form 10-K under the heading
      "Changes In and Disagreements With Accountants on Accounting and Financial
      Disclosure."

    If you are a stockholder, we may have sent you some of the documents
incorporated by reference, but you can obtain any of them from the SEC at its
Internet web site at HTTP://WWW.SEC.GOV or at its Public Reference Room at 450
Fifth Street, N.W., Room 1024, Washington, DC 20549. The documents are also
available from us without charge by requesting them in writing or by telephone
from Genzyme Corporation, One Kendall Square, Cambridge, Massachusetts 02139,
Attention: Shareholder Relations, phone: (617) 252-7526.

                            ------------------------

                                       33
<PAGE>
                                   APPENDIX A
                PROPOSED AMENDMENT AND RESTATEMENT TO GENZYME'S
                            ARTICLES OF ORGANIZATION

    THE FOLLOWING IS THE TEXT OF ARTICLE IV OF THE ARTICLES OF ORGANIZATION OF
GENZYME CORPORATION AS PROPOSED TO BE AMENDED AND RESTATED.

                                   ARTICLE IV
                          DESCRIPTION OF CAPITAL STOCK

A. AUTHORIZED CAPITAL STOCK

    The total number of shares of all classes of capital stock which the
Corporation shall be authorized to issue is four hundred million (400,000,000)
shares, consisting of three hundred ninety million (390,000,000) shares of
Common Stock, $.01 par value per share (the "Common Stock") and ten million
(10,000,000) shares of Preferred Stock, $.01 par value per share (the "Preferred
Stock").

B.  UNDESIGNATED COMMON STOCK

    Shares of Common Stock not at the time designated as shares of a particular
series pursuant to this Section IV.B. or any other provision of these Articles
of Organization may be issued from time to time in one or more additional
series. The Board of Directors may determine, in whole or in part, the
preferences, voting powers, qualifications and special or relative rights or
privileges of any such series before the issuance of any shares of that series,
provided that in no event shall the holder of a share of any series of Common
Stock be entitled to more than one vote per share at the time that shares of
such series are first issued. The Board of Directors shall determine the number
of shares constituting each series of Common Stock and each series shall have a
distinguishing designation.

C.  GENZYME GENERAL DIVISION COMMON STOCK

    1.  AUTHORIZED AMOUNTS.  Two hundred million (200,000,000) shares of Common
Stock are designated as a series of Common Stock with the following designation:
Genzyme General Division Common Stock (the "GGD Stock"). To the extent legally
permitted, such number of shares may be increased or decreased by vote of the
Board of Directors, provided that no decrease shall reduce the number of shares
of GGD Stock to a number less than the number of shares of such series then
outstanding plus the number of shares of such series reserved for issuance upon
the exercise of outstanding options, rights or warrants or upon the conversion
of any outstanding securities issued by the Corporation convertible into such
series of Common Stock. A description of the GGD Stock and a statement of its
preferences, voting powers, qualifications and special or relative rights or
privileges is as follows:

    2.  DIVIDENDS AND DISTRIBUTIONS.  Subject to the express terms of any
outstanding series of Preferred Stock, dividends may be declared and paid upon
the GGD Stock, in such amounts and at such times as the Board of Directors may
determine, only out of the lesser of (a) funds of the Corporation legally
available therefor and (b) the Available GGD Dividend Amount.

    3.  VOTING RIGHTS.  The holders of GGD Stock, voting together with the
holders of shares of all other series of Common Stock as a single class of
stock, shall have the exclusive right to vote for the election of directors and
on all other matters requiring action by the stockholders or submitted to the
stockholders for action, except as may be determined by the Board of Directors
in establishing any series of Common or Preferred Stock or as may otherwise be
required by law. Each share of the GGD Stock shall entitle the holder thereof to
one vote.

                                      A-1
<PAGE>
    4.  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any voluntary or
involuntary liquidation, dissolution or winding up of the Corporation, the
rights of the holders of GGD Stock shall be as follows:

        (a) After the Corporation has satisfied or made provision for its debts
    and obligations and for the payment to the holders of shares of any class or
    series of capital stock having preferential rights to receive distributions
    of the net assets of the Corporation (including any accumulated and unpaid
    dividends), the holders of GGD Stock shall be entitled to receive the net
    assets of the Corporation remaining for distribution, on a per share basis
    in proportion to the respective liquidation units per share of all series of
    Common Stock. Each share of GGD Stock shall have one hundred
    (100) liquidation units.

        (b) For the purposes of Section IV.C.4(a), any merger or business
    combination involving the Corporation or any sale of all or substantially
    all of the assets of the Corporation shall not be treated as a liquidation.

    5.  SPECIAL VOTING RIGHTS.  The Corporation shall not, without approval by
the holders of the GGD Stock at a meeting at which a quorum is present and the
votes cast in favor of the proposal exceed those cast against:

        (a) allow any proceeds from the Disposition of the properties or assets
    allocated to Genzyme General Division to be used in the business of any
    other Division without fair compensation being allocated to Genzyme General
    Division as determined by the Board of Directors;

        (b) allow any properties or assets allocated to Genzyme General Division
    to be used in the business of any other Division or for the declaration or
    payment of any dividend or distribution on any series of Common Stock other
    than the GGD Stock without fair compensation being allocated to Genzyme
    General Division as determined by the Board of Directors;

        (c) issue, sell or otherwise distribute shares of GGD Stock without
    allocating the proceeds or other benefits of such issuance, sale or
    distribution to Genzyme General Division;

        (d) change the rights or preferences of the GGD Stock so as to affect
    the GGD Stock adversely; or

        (e) effect any merger or business combination involving the Corporation
    as a result of which (a) the holders of all series of Common Stock of the
    Corporation shall no longer own, directly or indirectly, at least fifty
    percent (50%) of the voting power of the surviving corporation and (b) the
    holders of all series of Common Stock of the Corporation do not receive the
    same form of consideration, distributed among such holders in proportion to
    the Market Capitalization of each series of Common Stock as of the date of
    the first public announcement of such merger or business combination.

    6.  DEFINITIONS.  As used in this Section IV.C., the following terms shall
have the following meanings (with terms defined in the singular having
comparable meaning when used in the plural and vice versa), unless another
definition is provided or the context otherwise requires:

        (a) "Available GGD Dividend Amount," on any date, shall mean the greater
    of:

           (1) the excess of

               (A) the greater of (x) the fair value on such date of the net
           assets of Genzyme General Division and (y) an amount equal to
           $335,378,000 (stockholders' equity allocated to Genzyme General
           Division at June 30, 1994), such dollar amount to be increased or
           decreased, as appropriate, to reflect, after June 30, 1994, (A) the
           Earnings Attributable to Genzyme General Division, (B) any dividends
           or other distributions (including by reclassification or exchange)
           declared or paid with respect to, or repurchases or issuances of, any
           shares of GGD Stock or any other class of capital stock attributed to
           Genzyme General

                                      A-2
<PAGE>
           Division, but excluding dividends or other distributions paid in
           shares of GGD Stock to the holders thereof or in shares of any other
           class of capital stock attributed to Genzyme General Division to the
           holders thereof, and (C) any other adjustments to the stockholders'
           equity of Genzyme General Division made in accordance with generally
           accepted accounting principles, over

               (B) the sum of (x) the aggregate par value of all outstanding
           shares of GGD Stock and any other class of capital stock attributed
           to Genzyme General Division and (y) unless these Articles of
           Organization permit otherwise, the aggregate amount that would be
           needed to satisfy any preferential rights to which holders of all
           outstanding Preferred Stock attributed to Genzyme General Division
           are entitled upon dissolution of the Corporation in excess of the
           aggregate par value of such Preferred Stock, provided that such
           excess shall be reduced by any amount necessary to enable Genzyme
           General Division to pay its debts as they become due, and

           (2) the amount legally available for the payment of dividends
       determined in accordance with Massachusetts law applied as if Genzyme
       General Division were a separate corporation.

        (b) "Earnings Attributable" to Genzyme General Division for any period,
    shall mean the net income or loss of Genzyme General Division for such
    period (or for the fiscal periods of the Corporation commencing prior to the
    GTR Effective Date and after June 30, 1994, pro forma net income or loss of
    Genzyme General Division as if the GTR Effective Date were June 30, 1994)
    determined in accordance with generally accepted accounting principles, with
    all income and expenses of the Corporation being allocated between Divisions
    in a reasonable and consistent manner in accordance with policies adopted by
    the Board of Directors; provided, however, that as of the end of any fiscal
    quarter of the Corporation, any projected annual tax benefit attributable to
    any Division that cannot be utilized by such Division to offset or reduce
    its allocated tax liability may be allocated to any other Division without
    any compensating payment or allocation.

        (c) "Genzyme General Division" shall mean, at any time, the
    Corporation's interest in (i) all of the businesses, products, or
    development or research programs in which the Corporation or any of its
    subsidiaries (or any of their predecessors or successors) is or has been
    engaged, directly or indirectly, other than those allocated to any division
    of the Corporation represented by a series of Common Stock (any "Division")
    other than the GGD Stock; and (ii) all assets and liabilities of the
    Corporation to the extent allocated to any such businesses, products, or
    development or research programs in accordance with generally accepted
    accounting principles consistently applied for all of the Corporation's
    business units. From and after the date on which all of the outstanding
    shares of any series of Common Stock are exchanged for shares of GGD Stock,
    other securities, cash, other property or a combination thereof, all of the
    businesses, products, development or research programs, assets and
    liabilities of the Division represented by such series of Common Stock shall
    be included in Genzyme General Division. Genzyme General Division shall be
    represented by the GGD Stock.

D. GENZYME MOLECULAR ONCOLOGY COMMON STOCK

    1.  AUTHORIZED AMOUNTS AND DESIGNATIONS.  Forty million (40,000,000) shares
of Common Stock are designated as a series of Common Stock with the following
designation: Genzyme Molecular Oncology Division Common Stock (the "GMO Stock").
To the extent legally permitted, such number of shares may be increased or
decreased by vote of the Board of Directors, provided that no decrease shall
reduce the number of shares of GMO Stock to a number less than the number of
shares of such series then outstanding plus the number of shares of such series
reserved for issuance upon the exercise of outstanding options, rights or
warrants or upon the conversion of any outstanding securities issued by the
Corporation convertible into such series of Common Stock.

                                      A-3
<PAGE>
    2.  DIVIDENDS AND DISTRIBUTIONS.  Subject to the express terms of any
outstanding series of Preferred Stock, dividends may be declared and paid upon
the GMO Stock, in such amounts and at such times as the Board of Directors may
determine, only out of the lesser of (a) funds of the Corporation legally
available therefor and (b) the Available GMO Dividend Amount.

    3.  VOTING RIGHTS.  The holders of GMO Stock, voting together with the
holders of shares of all other series of Common Stock as a single class of
stock, shall have the exclusive right to vote for the election of directors and
on all other matters requiring action by the stockholders or submitted to the
stockholders for action, except as may be determined by the Board of Directors
in establishing any series of Common or Preferred Stock or as may otherwise be
required by law. Each share of GMO Stock shall entitle the holder thereof to .08
vote through December 31, 2000. On January 1, 2001 and on each January 1 every
two years thereafter, the number of votes to which the holder of each share of
GMO Stock shall be entitled shall be adjusted and fixed for two-year periods to
equal the quotient (expressed as a decimal and rounded to the nearest two
decimal places) obtained by dividing (i) the Fair Market Value of one share of
GMO Stock by (ii) Fair Market Value of one share of GGD Stock as of such date.
If no shares of GGD Stock are outstanding on such date, then all other series of
voting Common Stock outstanding on such date shall have a number of votes such
that each share of the series of outstanding Common Stock that has the highest
Fair Market Value per share on such date (the "Base Series") shall have one vote
and each share of each other series of outstanding Common Stock shall have the
number of votes determined according to the immediately preceding sentence,
treating, for such purpose, the Base Series as the GGD Stock in such sentence.
If shares of GMO Stock are entitled to vote separately as a class, each share of
GMO Stock shall have one vote.

    4.  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any voluntary or
involuntary liquidation, dissolution or winding up of the Corporation, the
rights of the holders of GMO Stock shall be as follows:

        (a) After the Corporation has satisfied or made provision for its debts
    and obligations and for the payment to the holders of shares of any class or
    series of capital stock having preferential rights to receive distributions
    of the net assets of the Corporation (including any accumulated and unpaid
    dividends), the holders of GMO Stock shall be entitled to receive the net
    assets of the Corporation remaining for distribution, on a per share basis
    in proportion to the respective liquidation units per share of all series of
    Common Stock. Each share of GMO Stock shall, subject to Section IV.G.4.,
    have 25 liquidation units.

        (b) For the purposes of Section IV.D.4(a) any merger or business
    combination involving the Corporation or any sale of all or substantially
    all of the assets of the Corporation shall not be treated as a liquidation.

    5.  SPECIAL VOTING RIGHTS.  The Corporation shall not, without approval by
the holders of the GMO Stock at a meeting at which a quorum is present and the
votes cast in favor of the proposal exceed those cast against:

        (a) allow any proceeds from the Disposition of the properties or assets
    allocated to Genzyme Molecular Oncology Division to be used in the business
    of any other Division without fair compensation being allocated to Genzyme
    Molecular Oncology Division as determined by the Board of Directors;

        (b) allow any properties or assets allocated to Genzyme Molecular
    Oncology Division to be used in the business of any other Division or for
    the declaration or payment of any dividend or distribution on any series of
    Common Stock other than the GMO Stock without fair compensation being
    allocated to Genzyme Molecular Oncology Division as determined by the Board
    of Directors;

        (c) issue, sell or otherwise distribute shares of GMO Stock without
    allocating the proceeds or other benefits of such issuance, sale or
    distribution to Genzyme Molecular Oncology Division; provided, however, that
    the Corporation may without such approval issue GMO Designated Shares;

                                      A-4
<PAGE>
        (d) change the rights or preferences of the GMO Stock so as to affect
    the GMO Stock adversely; or

        (e) effect any merger or business combination involving the Corporation
    as a result of which (i) the holders of all series of Common Stock of the
    Corporation shall no longer own, directly or indirectly, at least fifty
    percent (50%) of the voting power of the surviving corporation and (ii) the
    holders of all series of Common Stock of the Corporation do not receive the
    same form of consideration, distributed among such holders in proportion to
    the Market Capitalization of each series of Common Stock as of the date of
    the first public announcement of such merger or business combination.

    Notwithstanding the foregoing, if the Corporation receives an opinion of
Qualified Tax Counsel that, by reason of any Tax Law Change, the special voting
rights of the GMO Stock set forth in this subsection 5 would cause a Tax Event
absent the termination of such rights, then the Corporation may, by vote of a
majority of the stock outstanding and entitled to vote thereon, voting together
as a single class, authorize an amendment to these Articles of Organization to
effect the termination of such rights in order to avoid the occurrence of such
Tax Event. Any such amendment shall not be deemed to change the rights or
preferences of the GMO Stock so as to affect the GMO Stock adversely as
contemplated by either Section IV.D.5(d) or Section 77 of the Massachusetts
Business Corporation Law.

    6.  EXCHANGE OR REDEMPTION OF GMO STOCK.  Shares of GMO Stock are subject to
exchange or redemption upon the terms and conditions set forth below:

        (a)  OPTIONAL EXCHANGE OF GMO STOCK.

           (1) The Board of Directors may at any time, including without
       limitation in the event of the reallocation, in one transaction or a
       series of related transactions, by the Corporation and/or its
       subsidiaries of all or substantially all of the properties and assets
       allocated to Genzyme Molecular Oncology Division to any other Division of
       Genzyme, declare that each of the outstanding shares of GMO Stock shall
       be exchanged, on an Exchange Date, as determined by the Board of
       Directors, for (a) a number of fully paid and nonassessable shares of GGD
       Stock (calculated to the nearest five decimal places) equal to (1) 130%
       of the Fair Market Value of one share of the GMO Stock (the "GMO Optional
       Exchange Amount") as of the date of the first public announcement by the
       Corporation (the "GMO Optional Exchange Announcement Date") of such
       exchange divided by (2) the Fair Market Value of one share of GGD Stock
       as of such GMO Optional Exchange Announcement Date or (b) cash equal to
       the GMO Optional Exchange Amount, or (c) any combination of GGD Stock and
       cash equal to the GMO Optional Exchange Amount as determined by the Board
       of Directors.

           (2) If the Corporation receives an opinion of Qualified Tax Counsel
       that a Tax Event has occurred by reason of any Tax Law Change, then the
       Board of Directors may at any time declare that each of the outstanding
       shares of GMO Stock shall be exchanged, on an Exchange Date, as
       determined by the Board of Directors, for a number of fully paid and
       nonassessable shares of GGD Stock (calculated to the nearest five decimal
       places) equal to (1) the Fair Market Value of one share of the GMO Stock
       as of the date of the first public announcement by the Corporation of
       such exchange divided by (2) the Fair Market Value of one share of GGD
       Stock as of such date.

           (3) At any time at which all of the assets and liabilities attributed
       to Genzyme Molecular Oncology Division (and no other assets or
       liabilities of the Corporation or any subsidiary thereof) are held
       directly or indirectly by one or more wholly-owned subsidiaries of the
       Corporation (each, a "GMO Subsidiary"), the Board of Directors may,
       provided that there are funds of the Corporation legally available
       therefor, exchange on an Exchange Date, as determined by the Board of
       Directors, all of the outstanding shares of GMO Stock for that number of
       the shares of

                                      A-5
<PAGE>
       common stock of each GMO Subsidiary equal to the number of such GMO
       Subsidiary shares outstanding immediately prior to such exchange
       multiplied by the GMO Allocation Ratio, such shares of common stock of
       each GMO Subsidiary to be delivered to the holders of shares of GMO Stock
       on the Exchange Date either directly or indirectly through the delivery
       of shares of another GMO Subsidiary that owns directly or indirectly all
       such shares, and to be divided among the holders of GMO Stock on a pro
       rata basis in accordance with the number of shares of GMO Stock held by
       each such holder, each of which shares of common stock of such GMO
       Subsidiary shall be, upon such delivery, fully paid and nonassessable;
       PROVIDED, HOWEVER, that upon any such exchange, any existing GMO
       Designated Shares shall be cancelled in exchange for the allocation to
       Genzyme General of the direct or indirect interest of the Corporation in
       any remaining outstanding shares of each such GMO Subsidiary that are not
       transferred to the holders of GMO Stock in such exchange.

        (b)  MANDATORY EXCHANGE OR REDEMPTION OF OR PAYMENT OF DIVIDEND ON GMO
    STOCK.

           (1)  GMO MANDATORY PAYMENT.  In the event of the Disposition, in one
       transaction or a series of related transactions, by the Corporation and
       or its subsidiaries of all or substantially all of the properties and
       assets allocated to Genzyme Molecular Oncology Division to any person,
       entity or group (other than a Disposition of a type set forth in
       subsection (2) of this subsection (b)), on or prior to the 60th Business
       Day, or such earlier date required under this Section IV.D.6, following
       the date of the GMO Mandatory Payment Announcement (as defined in
       Section IV.D.6(d)(2)), the Corporation shall select one of the following
       alternatives, as determined by the Board of Directors in its discretion:

               (A) provided that there are funds of the Corporation legally
           available therefor, pay to the holders of the shares of GMO Stock a
           dividend on a pro rata basis in accordance with the number of shares
           of GMO Stock held by each such holder in cash, securities (other than
           shares of a series of Common Stock) and or other property having a
           Fair Market Value as of the date of the Disposition in the aggregate
           equal to the Fair Market Value as of the date of the Disposition of
           the GMO Net Proceeds of such Disposition; or

               (B) provided that there are funds of the Corporation legally
           available therefor,

                   (i) if such Disposition involves all (not merely
               substantially all) of the properties and assets attributed to
               Genzyme Molecular Oncology Division, redeem or exchange as of a
               Redemption Date determined by the Board of Directors, all
               outstanding shares of GMO Stock in exchange for, on a pro rata
               basis, cash, securities (other than shares of a series of Common
               Stock) and or other property having a Fair Market Value as of the
               date of the Disposition in the aggregate equal to the Fair Market
               Value as of the date of the Disposition of the GMO Net Proceeds
               of such Disposition; or

                   (ii) if such Disposition involves substantially all (but not
               all) of the properties and assets attributed to Genzyme Molecular
               Oncology Division, redeem or exchange as of a Redemption Date as
               determined by the Board of Directors such number of whole shares
               of GMO Stock (which may be all, but not more than all, of such
               shares outstanding) as have in the aggregate an average Closing
               Price during the period of ten (10) consecutive Business Days
               beginning on the first Business Day immediately following the
               date of the Estimated GMO Net Proceeds Announcement (as defined
               in Section IV.D.6(d)(2)) closest to the Fair Market Value as of
               the date of the Disposition of the GMO Net Proceeds of such
               Disposition in consideration for, on a pro rata basis, cash
               securities (other than shares of a series of Common Stock) and or
               other property having a Fair Market Value as of the date of the
               Disposition in the aggregate equal to such Fair Market Value of
               the GMO Net Proceeds; or

                                      A-6
<PAGE>
               (C) declare that each outstanding share of GMO Stock shall be
           exchanged as of an Exchange Date as determined by the Board of
           Directors into a number of fully paid and nonassessable shares of GGD
           Stock equal to 110% of the ratio (calculated to the nearest five
           decimal places) of the average Closing Price of one share of GMO
           Stock over the period of ten (10) consecutive Business Days beginning
           on the first Business Day immediately following the date of the
           Estimated GMO Net Proceeds Announcement (as defined in
           Section IV.D.6(d)(2)) to the average Closing Price of one share of
           GGD Stock over the same ten Business Day period.

Any redemption or exchange of or dividend payment on GMO Stock made pursuant to
this Section IV.D.6(b)(1) or Section IV.D.6(c)(3) is hereinafter referred to as
a "GMO Mandatory Payment." Notwithstanding the foregoing provisions of this
Section IV.D.6.(b), the Corporation shall redeem GMO Stock as provided by
Section IV.D.(b)(1)(B) only if the amount to be paid pursuant to such redemption
is less than or equal to the Available GMO Dividend Amount as of the Redemption
Date.

           (2)  EXCEPTIONS TO MANDATORY PAYMENT.  Notwithstanding the foregoing
       Section IV.D.6(b)(1) or Section IV.D.6(c)(3), a GMO Mandatory Payment
       shall not be required by the occurrence of a Disposition:

               (A) by the Corporation of all or substantially all of the
           Corporation's properties and assets in one transaction or a series of
           related transactions, including such Disposition in connection with
           the dissolution, liquidation or winding up of the Corporation and the
           distribution of assets to stockholders as referred to in
           Section IV.D.4;

               (B) of the properties and assets attributed to Genzyme Molecular
           Oncology Division as contemplated by Section IV.D.6(a)(3) or
           otherwise to all holders of GMO Stock divided among such holders on a
           pro rata basis in accordance with the number of shares GMO Stock
           outstanding;

               (C) to any person or entity controlled (as determined by the
           Board of Directors) by the Corporation;

               (D) in connection with a Related Business Transaction in respect
           of Genzyme Molecular Oncology Division; or

               (E) that is conditioned upon the affirmative vote of the holders
           of GMO Stock, voting as a separate class.

        (c)  TERMINATION OF CASH EXCHANGE RIGHT.  If the Corporation receives an
    opinion of Qualified Tax Counsel that, by reason of any Tax Law Change, the
    right or obligation of the Corporation to exchange GMO Stock for cash,
    securities or other property pursuant to Section IV.D.6(a)(1) or (3) or
    IV.D.6(b) (each, a "GMO Cash Exchange Right") would cause a Tax Event if not
    terminated, then the Board of Directors may at any time, by a vote of a
    majority of the directors then in office, elect to terminate any or all such
    GMO Cash Exchange Rights, with the result that the Corporation shall
    thereafter have, depending on which GMO Cash Exchange Right(s) is (are) so
    terminated:

           (1) under Section IV.D.6(a)(1) only the right to cause the exchange
       of GMO Stock for GGD Stock and not for cash, securities or other property
       other than capital stock of the Corporation,

           (2) no right to effect an exchange under Section IV.D.6(a)(3), and/or

           (3) no right or obligation to effect a GMO Mandatory Payment under
       Section IV.D.6(b), provided that if the Board shall no longer have the
       right or obligation to effect a GMO Mandatory Payment under
       Section IV.D.6(b), then if a GMO Mandatory Payment thereunder shall
       otherwise be or have been required, the Corporation instead shall have
       the obligation to effect on or prior to the first Business Day after the
       90th day following the consummation of such

                                      A-7
<PAGE>
       Disposition, a GMO Mandatory Payment pursuant to which it shall exchange
       each outstanding share of GMO Stock for a number of fully paid and
       nonassessable shares of GGD Stock (calculated to the nearest five decimal
       places) equal to (i) the Fair Market Value of one share of the GMO Stock
       as of the date of the first public announcement of such Disposition by
       the Corporation by press release divided by (ii) the Fair Market Value of
       one share of GGD Stock as of such date.

    Notwithstanding the foregoing, the Board of Directors may not terminate any
GMO Cash Exchange Right during the period commencing on the date of a
Disposition requiring a GMO Mandatory Payment until the date upon which the
related Mandatory Payment is effected by the Corporation.

        (d)  EXCHANGE AND REDEMPTION PROCEDURES.

           (1) If the Corporation determines to exchange shares of GMO Stock
       pursuant to Section IV.D.6(a), the Corporation shall cause notice to be
       sent not less than 30 nor more than 60 days prior to the Exchange Date in
       the form and manner set forth in Section IV.G.1, and the procedures
       governing such exchange shall be those set forth in Section IV.G.1.

           (2) Not later than the 20th Business Day following the consummation
       of a Disposition described in Section IV.D.6(b)(1) with respect to
       Genzyme Molecular Oncology Division, the Corporation shall announce
       publicly by press release (1) the estimated GMO Net Proceeds, (2) the
       number of outstanding shares of GMO Stock and (3) the number of shares of
       GMO Stock into or for which Convertible Securities are then convertible,
       exchangeable or exercisable and the conversion, exchange or exercise
       price thereof (the "Estimated GMO Net Proceeds Announcement"). Not
       earlier than the day immediately following the 10th Business Day, nor
       later than the 20th Business Day, following the date of the Estimated GMO
       Net Proceeds Announcement, the Corporation shall announce publicly by
       press release which of the actions specified in Section IV.D.6(b)(1) that
       it has irrevocably determined to make in respect of such Disposition (the
       "GMO Mandatory Payment Announcement").

           (3) If the Corporation determines to pay a dividend pursuant to
       Section IV.D.6(b)(1)(A), the Corporation shall, not later than the 20th
       Business Day following the date of the Estimated GMO Net Proceeds
       Announcement, cause notice to be sent to the holders of shares of GMO
       Stock and to each holder of Convertible Securities that are convertible
       into or exchangeable or exercisable for shares of GMO Stock (unless
       alternate provision for such notice to the holders of such Convertible
       Securities is made pursuant to the terms of such Convertible Securities),
       setting forth (1) the record date for determining holders entitled to
       receive such dividend, which shall be not earlier than the 10th Business
       Day and not later than the 20th Business Day following the date of such
       notice, (2) the anticipated payment date of such dividend (which shall
       not be more than 60 Business Days following the date of the GMO Mandatory
       Payment Announcement), (3) the type and amount of property to be paid as
       such dividend in respect of the outstanding shares of GMO Stock, (4) the
       GMO Net Proceeds, (5) the number of outstanding shares of GMO Stock and
       the number of shares of GMO Stock into or for which outstanding
       Convertible Securities are then convertible, exchangeable or exercisable
       and the conversion, exchange or exercise price thereof and (6) in the
       case of notice to be given to holders of Convertible Securities, a
       statement to the effect that a holder of such Convertible Securities
       shall be entitled to receive such dividend only if such holder properly
       converts, exchanges or exercises such Convertible Securities (unless the
       terms of a Convertible Security provide otherwise) on or prior to the
       record date referred to in clause (1) of this sentence. Except as
       provided in the preceding sentence, such notice shall conform with the
       provisions governing notice at Section IV.G.1 and the provisions
       governing the payment of such dividend shall be those set for in such
       Section IV.G.1 to the extent such provisions are applicable to the
       payment of a dividend.

                                      A-8
<PAGE>
           (4) If the Corporation determines to redeem shares of GMO Stock
       pursuant to Section IV.D.6(b)(1)(B)(i), the Corporation shall, not later
       than the 20th Business Day following the date of the Estimated GMO Net
       Proceeds Announcement, cause notice to be sent in the form and manner set
       forth in Section IV.G.1, and the procedures governing such redemption
       shall be those set forth in Section IV.G.1; PROVIDED, HOWEVER, the
       Redemption Date shall not be more than 60 Business Days following the
       date of the GMO Mandatory Payment Announcement. Such notice shall also
       state the GMO Net Proceeds.

           (5) If the Corporation determines to redeem shares of GMO Stock
       pursuant to Section IV.D.6(b)(1)(B)(ii), the Corporation shall, not later
       than the 20th Business Day following the date of the GMO Estimated Net
       Proceeds Announcement, cause notice to be sent in the form and manner set
       forth in Section IV.G.1, and the procedures governing such redemption
       shall be those set forth in Section IV.G.1; PROVIDED, HOWEVER, the
       Redemption Date shall not be more than 60 Business Days following the
       date of the Estimated GMO Net Proceeds Announcement. The notice delivered
       hereunder shall also state (a) the GMO Net Proceeds and (b) a date (the
       "selection date") not earlier than the 10th Business Day and not later
       than the 20th Business Day following the date of such notice on which
       shares of GMO Stock shall be selected for redemption and that the
       Corporation will not be required to register a transfer of any shares of
       GMO Stock for a period of ten (10) Business Days next preceding the
       Selection Date.

           (6) If the Corporation determines to exchange GMO Stock for GGD Stock
       pursuant to Section IV.D.6(b)(1)(C), the Corporation shall cause notice
       to be sent in the form and manner set forth in Section IV.G.1, and the
       procedures governing such exchange shall be those set forth in
       Section IV.G.1; PROVIDED, HOWEVER, the Exchange Date shall not be more
       than 60 Business Days following the date of the GMO Mandatory Payment
       Announcement. Such notice shall also state the GMO Net Proceeds.

           (7) If the Corporation determines to exchange GMO Stock for GGD Stock
       pursuant to Section IV.D.6(c)(3), the Corporation shall cause notice to
       be sent not less than 30 nor more than 60 days in the form and manner set
       forth in Section IV.G.1, and the procedures governing such exchange shall
       be those set forth in Section IV.G.1.

        (e)  SPECIAL MANDATORY PAYMENT PROVISIONS.  For purposes of this
    Section IV.D.6:

           (1) "substantially all of the properties and assets allocated to
       Genzyme Molecular Oncology Division" shall mean a portion of the
       properties and assets allocated to Genzyme Molecular Oncology Division
       (A) that represents at least 80% of the then-current fair value (as
       determined by the Board of Directors) of, or (B) to which is attributable
       at least 80% of the aggregate revenues for the immediately preceding
       twelve fiscal quarterly periods of the Corporation derived from, the
       properties and assets allocated to Genzyme Molecular Oncology Division;

           (2) in the case of a Disposition of properties and assets in a series
       of related transactions, such Disposition shall not be deemed to have
       been consummated until the consummation of the last of such transactions;
       and

           (3) in the event that at the time of any Disposition there are
       outstanding any Convertible Securities convertible into or exercisable
       for shares of GMO Stock that would give the holders rights to receive any
       dividend related to the Disposition upon exercise, conversion or
       otherwise, or would adjust as a result of such dividend to give the
       holder equivalent economic rights, then the shares of GMO Stock
       underlying such Convertible Securities will be taken into account for
       purposes of computing the GMO Allocation Ratio and determining the terms
       of any dividend payment on such shares;

           (4) in the event that as a result of or in connection with a dividend
       payment pursuant to Section IV.D.6(b)(1)(A) there ceases to be any
       properties or assets attributed to Genzyme

                                      A-9
<PAGE>
       Molecular Oncology Division, then each outstanding share of GMO Stock
       shall immediately following such dividend payment be cancelled and all
       rights of a holder of a share of GMO Stock shall cease except for the
       right to such dividend payment; and

           (5) there shall be added to any cash portion of a GMO Mandatory
       Payment paid to holders of GMO Stock, which cash comprised a portion of
       the GMO Net Proceeds, any interest earned by Genzyme Molecular Oncology
       Division or the Corporation on such cash from the date of the Disposition
       up to the record date of such GMO Mandatory Payment.

    7.  DEFINITIONS.  As used in this Section IV.D., the following terms shall
have the following meanings (with terms defined in the singular having
comparable meaning when used in the plural and vice versa), unless another
definition is provided or the context otherwise requires. Capitalized terms used
but not defined in this Section IV.D.7 shall have the meanings given them in
Section IV.G.7.

        (a) "Available GMO Dividend Amount," on any date, shall mean the greater
    of:

           (1) the excess of

               (A) the greater of (x) the fair value on such date of the net
           assets of Genzyme Molecular Oncology Division and (y) an amount equal
           to $20,500,000 (stockholders' equity allocated to Genzyme Molecular
           Oncology Division at September 30, 1996), such dollar amount to be
           increased or decreased, as appropriate, to reflect, after
           September 30, 1996, (A) the Earnings Attributable to Genzyme
           Molecular Oncology Division, (B) any dividends or other distributions
           (including by reclassification or exchange) declared or paid with
           respect to, or repurchases or issuances of, any shares of GMO Stock
           or any other class of capital stock attributed to Genzyme Molecular
           Oncology Division, but excluding dividends or other distributions
           paid in shares of GMO Stock to the holders thereof or in shares of
           any other class of capital stock attributed to Genzyme Molecular
           Oncology Division to the holders thereof, and (C) any other
           adjustments to the stockholders' equity of Genzyme Molecular Oncology
           Division made in accordance with generally accepted accounting
           principles, over

               (B) the sum of (x) the aggregate par value of all outstanding
           shares of GMO Stock and any other class of capital stock attributed
           to Genzyme Molecular Oncology Division and (y) unless these Articles
           of Organization permit otherwise, the aggregate amount that would be
           needed to satisfy any preferential rights to which holders of all
           outstanding Preferred Stock attributed to Genzyme Molecular Oncology
           Division are entitled upon dissolution of the Corporation in excess
           of the aggregate par value of such Preferred Stock, provided that
           such excess shall be reduced by any amount necessary to enable
           Genzyme Molecular Oncology Division to pay its debts as they become
           due, and

           (2) the amount legally available for the payment of dividends
       determined in accordance with Massachusetts law applied as if Genzyme
       Molecular Oncology Division were a separate corporation.

        (b) "Earnings Attributable" to Genzyme Molecular Oncology Division for
    any period, shall mean the net income or loss of Genzyme Molecular Oncology
    Division for such period (or for the fiscal periods of the Corporation
    commencing prior to the GMO Effective Date and after September 30, 1996, pro
    forma net income or loss of Genzyme Molecular Oncology Division as if the
    GMO Effective Date were September 30, 1996) determined in accordance with
    generally accepted accounting principles, with all income and expenses of
    the Corporation being allocated between Divisions in a reasonable and
    consistent manner in accordance with policies adopted by the Board of
    Directors; provided, however, that as of the end of any fiscal quarter of
    the Corporation, any projected annual tax benefit attributable to any
    Division that cannot be utilized by such Division to offset or reduce its

                                      A-10
<PAGE>
    allocated tax liability may be allocated to any other Division without any
    compensating payment or allocation.

        (c) "GMO Allocation Ratio," as of any date, shall mean the fraction
    computed by dividing the GMO Shares Outstanding by the sum of the GMO Shares
    Outstanding plus the GMO Designated Shares.

        (d) "GMO Designated Shares" as of any date shall mean a number of shares
    of GMO Stock that, as of the GMO Effective Date, shall be 6,000,000, which
    number shall be subject to adjustment as provided in the next sentence. The
    number of GMO Designated Shares shall from time to time be

           (1) adjusted as appropriate to reflect subdivisions (by stock split
       or otherwise) and combinations (by reverse stock split or otherwise) of
       the GMO Stock and dividends or distributions of shares of GMO Stock to
       holders of GMO Stock and other reclassifications of GMO Stock,

           (2) decreased by (A) the number of any shares of GMO Stock issued by
       the Corporation, the proceeds of which are allocated to Genzyme General
       Division, (B) the number of any shares of GMO Stock issued upon the
       exercise or conversion of Convertible Securities attributed to Genzyme
       General Division, and (C) the number of any shares of GMO Stock issued by
       the Corporation as a dividend or distribution or by reclassification,
       exchange or otherwise to holders of GGD Stock, and

           (3) increased by (A) the number of any outstanding shares of GMO
       Stock repurchased by the Corporation, the consideration for which was
       allocated to Genzyme General Division, (B) the number equal to the fair
       value (as determined by the Board of Directors) of assets or properties
       allocated to Genzyme General Division that are reallocated to Genzyme
       Molecular Oncology Division (other than reallocations that represent
       sales at fair value between such Divisions) divided by the Fair Market
       Value of one share of GMO Stock as of the date of such reallocation,
       (C) the number equal to the number of shares into which the Board of
       Directors elects to convert the promissory note dated February 10, 1997
       issued by PharmaGenics, Inc. to the Corporation pursuant to the terms of
       such promissory note and (D) with respect to the $25 million equity line
       from Genzyme General Division to Genzyme Molecular Oncology Division
       approved by the Corporation's Board of Directors on January 30, 1997 (the
       "Equity Line"), if

               (A) the closing of the first public offering by the Corporation
           of GMO Stock has occurred prior to the third anniversary of the GMO
           Effective Date, then, upon such closing, a number equal to the
           aggregate of the quotients obtained by dividing (i) the amount of
           each advance made under the Equity Line by (ii) the dollar amount
           determined for each such advance by the following formula:
           7.00 + [(IPOGMO - 7.00) X (ADATE/IPODATE)]; where IPOGMO = the
           offering price of the GMO Stock in the first such public offering,
           ADATE = the number of days from the GMO Effective Date to the time of
           such advance, and IPODATE = the number of days from the GMO Effective
           Date to the time of the first such public offering; and, thereafter,
           upon each advance made under the Equity Line, a number equal to the
           quotient obtained by dividing (i) the amount of each such advance by
           (ii) the Fair Market Value of the GMO Stock on the date of such
           advance; or

               (B) the closing of the first public offering by the Corporation
           of GMO Stock has not occurred prior to the third anniversary of the
           GMO Effective Date, then, upon the election of the Corporation's
           Board of Directors, a number equal to the quotient obtained by
           dividing (i) the aggregate amount of all advances made under the
           Equity Line by (ii) the Fair Market Value of the GMO Stock on the
           date of such third anniversary;

provided, that the Corporation shall take no action which would have the effect
of reducing the GMO Designated Shares to a number which is less than zero.
Within 45 days after the end of each fiscal quarter

                                      A-11
<PAGE>
of the Corporation, the Corporation shall prepare and file a statement of such
change with the transfer agent for the GMO Stock and with the Clerk of the
Corporation.

           (e) "GMO Effective Date" shall mean June 18, 1997.

           (f) "GMO Net Proceeds" shall mean, as of any date, with respect to a
       Disposition of any of the properties and assets of Genzyme Molecular
       Oncology Division, a fraction of the proceeds from such disposition
       determined by multiplying the GMO Allocation Ratio by the gross proceeds
       of such Disposition after any adjustment to such gross proceeds resulting
       from payment of, or reasonable provision for, (a) any taxes payable by
       the Corporation in respect of either such Disposition or any mandatory
       exchange, redemption or dividend payment resulting from such Disposition
       (or that would have been payable but for the utilization of tax benefits
       attributable to any division or group of the Corporation other than
       Genzyme Molecular Oncology Division (a "Non-GMO Division")), (b) any
       transaction costs borne by Non-GMO Division in connection with such
       Disposition, including, without limitation, any legal, investment banking
       and accounting fees and expenses borne by a Non-GMO Division in
       connection with such Disposition, (c) any liabilities and other
       obligations (contingent or otherwise) of Genzyme Molecular Oncology
       Division borne by a Non-GMO Division in connection with such Disposition,
       including, without limitation, any indemnity or guarantee obligations
       incurred by a Non-GMO Division in connection with the Disposition or any
       liabilities assumed by a Non-GMO Division for future purchase price
       adjustments, and (d) any preferential amounts, accumulated and unpaid
       dividends and other obligations in respect of any Preferred Stock
       attributed to Genzyme Molecular Oncology Division.

        (g) "GMO Shares Outstanding" as of any date shall mean the number of
    shares of GMO Stock then issued and outstanding.

        (h) "Genzyme Molecular Oncology Division" shall mean, at any time, the
    Corporation's interest in (i) the following businesses, products, or
    development or research programs: (A) the use of the Serial Analysis of Gene
    Expression ("SAGE") technology licensed from Johns Hopkins University School
    of Medicine for third parties; (B) the clinical program developing
    adenovirus vectors containing the tumor antigens MART 1 or gp100 for
    treatment of melanoma: (C) the "suicide" gene therapy research program
    developing adenovirus and lipid vectors containing genes to enhance
    chemotherapy for oncology indications; (D) the research program developing
    adenovirus and lipid vectors containing tumor suppressor genes for oncology
    indications; (E) the research program developing adenovirus and lipid
    containing genes to regulate the immune system for oncology indications,
    including heat shock proteins; (F) the research program developing
    antibody-targeted gene therapy for treatment of tumors; (G) the research
    program developing small molecule compounds to inhibit angiogenesis and
    stimulate apoptosis; (H) the research program developing small molecule
    compounds to regulate tumor suppressor gene function; and (I) the research
    program developing diagnostic applications for tumor suppressor genes and
    other cancer-related genes licensed from Hoffmann-La Roche Inc. or
    identified by Johns Hopkins University using SAGE technology or other
    genomic technology; (ii) all assets and liabilities of the Corporation to
    the extent allocated to any such businesses, products, or development or
    research programs in accordance with generally accepted accounting
    principles consistently applied for all of the Corporation's business units;
    (iii) to the extent not described above, all assets and liabilities of
    PharmaGenics, Inc. as of the GMO Effective Date; and (iv) such businesses,
    products, or development or research programs developed in, or acquired by
    the Corporation for, Genzyme Molecular Oncology Division after the GMO
    Effective Date, in each case as determined by the Board of Directors;
    provided, however, that, from and after any Disposition or transfer to
    Genzyme General Division of any business, product, development program,
    research project, assets or properties, Genzyme Molecular Oncology Division
    shall no longer include the business, product, development program, research
    project, assets or properties so disposed of or transferred. Genzyme
    Molecular Oncology Division shall be represented by the GMO Stock.

                                      A-12
<PAGE>
E.  GENZYME SURGICAL PRODUCTS DIVISION COMMON STOCK

    1.  AUTHORIZED AMOUNTS AND DESIGNATIONS.  Sixty million (60,000,000) shares
of Common Stock are designated as a series of Common Stock with the following
designation: Genzyme Surgical Products Division Common Stock (the "GSP Stock").
To the extent legally permitted, such number of shares may be increased or
decreased by vote of the Board of Directors, PROVIDED that no decrease shall
reduce the number of shares of GSP Stock to a number less than the number of
shares of such series then outstanding plus the number of shares of such series
reserved for issuance upon the exercise of outstanding options, rights or
warrants or upon the conversion of any outstanding securities issued by the
Corporation convertible into GSP Stock.

    2.  DIVIDENDS AND DISTRIBUTIONS.  Subject to the express terms of any
outstanding series of Preferred Stock, dividends may be declared and paid upon
the GSP Stock, in such amounts and at such times as the Board of Directors may
determine, only out of the lesser of (a) funds of the Corporation legally
available therefor and (b) the Available GSP Dividend Amount.

    3.  VOTING RIGHTS.  The holders of GSP Stock, voting together with the
holders of shares of all other series of Common Stock as a single class of
stock, shall have the exclusive right to vote for the election of directors and
on all other matters requiring action by the stockholders or submitted to the
stockholders for action, except as may be determined by the Board of Directors
in establishing any series of Common or Preferred Stock or as may otherwise be
required by law. Each share of GSP Stock shall entitle the holder thereof to .61
vote through December 31, 2000. On January 1, 2001 and on each January 1 every
two years thereafter, the number of votes to which the holder of each share of
GSP Stock shall be entitled shall be adjusted and fixed for two-year periods to
equal the quotient (expressed as a decimal and rounded to the nearest two
decimal places) obtained by dividing (i) the Fair Market Value of one share of
GSP Stock by (ii) the Fair Market Value of one share of GGD Stock as of such
date. If no shares of GGD Stock are outstanding on such date, then all other
series of voting Common Stock outstanding on such date shall have a number of
votes such that each share of the series of outstanding Common Stock that has
the highest Fair Market Value per share on such date (the "Base Series") shall
have one vote and each share of each other series of outstanding Common Stock
shall have the number of votes determined according to the immediately preceding
sentence, treating, for such purpose, the Base Series as the GGD Stock in such
sentence. If shares of GSP Stock are entitled to vote separately as a class,
each share of GSP Stock shall have one vote.

    4.  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any voluntary or
involuntary liquidation, dissolution or winding up of the Corporation, the
rights of the holders of GSP Stock shall be as follows:

        (a) After the Corporation has satisfied or made provision for its debts
    and obligations and for the payment to the holders of shares of any class or
    series of capital stock having preferential rights to receive distributions
    of the net assets of the Corporation (including any accumulated and unpaid
    dividends), the holders of GSP Stock shall be entitled to receive the net
    assets of the Corporation remaining for distribution, on a per share basis
    in proportion to the respective liquidation units per share of all series of
    Common Stock. Each share of GSP Stock shall, subject to this
    Section IV.E.4(a), have 61 liquidation units.

        (b) For the purposes of Section IV.E.4(a). any merger or business
    combination involving the Corporation or any sale of all or substantially
    all of the assets of the Corporation shall not be treated as a liquidation.

                                      A-13
<PAGE>
    5.  SPECIAL VOTING RIGHTS.  The Corporation shall not, without approval by
the holders of the GSP Stock at a meeting at which a quorum is present and the
votes cast in favor of the proposal exceed those cast against:

        (a) allow any proceeds from the Disposition of the properties or assets
    allocated to Genzyme Surgical Products Division to be used in the business
    of any other Division without fair compensation being allocated to Genzyme
    Surgical Products Division as determined by the Board of Directors;

        (b) allow any properties or assets allocated to Genzyme Surgical
    Products Division to be used in the business of any other Division or for
    the declaration or payment of any dividend or distribution on any series of
    Common Stock other than the GSP Stock without fair compensation being
    allocated to Genzyme Surgical Products Division as determined by the Board
    of Directors;

        (c) issue, sell or otherwise distribute shares of GSP Stock without
    allocating the proceeds or other benefits of such issuance, sale or
    distribution to Genzyme Surgical Products Division; PROVIDED, HOWEVER, that
    the Corporation may without such approval issue GSP Designated Shares;

        (d) change the rights or preferences of the GSP Stock so as to affect
    the GSP Stock adversely; or

        (e) effect any merger or business combination involving the Corporation
    as a result of which (i) the holders of all series of Common Stock of the
    Corporation shall no longer own, directly or indirectly, at least fifty
    percent (50%) of the voting power of the surviving corporation and (ii) the
    holders of all series of Common Stock of the Corporation do not receive the
    same form of consideration, distributed among such holders in proportion to
    the Market Capitalization of each series of Common Stock as of the date of
    the first public announcement of such merger or business combination.

    Notwithstanding the foregoing, if the Corporation receives an opinion of
Qualified Tax Counsel that, by reason of any Tax Law Change, the special voting
rights of the GSP Stock set forth in this subsection 5 would cause a Tax Event
absent the termination of such rights, then the Corporation may, by vote of a
majority of the stock outstanding and entitled to vote thereon, voting together
as a single class, authorize an amendment to these Articles of Organization to
effect the termination of such rights in order to avoid the occurrence of such
Tax Event. Any such amendment shall not be deemed to change the rights or
preferences of the GSP Stock so as to affect the GSP Stock adversely as
contemplated by either Section IV.E.5(d) or Section 77 of the Massachusetts
Business Corporation Law.

    6.  EXCHANGE OR REDEMPTION OF GSP STOCK.  Shares of GSP Stock are subject to
exchange or redemption upon the terms and conditions set forth below:

        (a)  OPTIONAL EXCHANGE OF GSP STOCK.

           (1) The Board of Directors may at any time, including without
       limitation in the event of the reallocation, in one transaction or a
       series of related transactions, by the Corporation and/or its
       subsidiaries of all or substantially all of the properties and assets
       allocated to Genzyme Surgical Products Division to any other Division of
       Genzyme, declare that each of the outstanding shares of GSP Stock shall
       be exchanged, on an Exchange Date, as determined by the Board of
       Directors, for (a) a number of fully paid and nonassessable shares of GGD
       Stock (calculated to the nearest five decimal places) equal to (1) 130%
       of the Fair Market Value of one share of the GSP Stock (the "GSP Optional
       Exchange Amount") as of the date of the first public announcement by the
       Corporation (the "GSP Optional Exchange Announcement Date") of such
       exchange divided by (2) the Fair Market Value of one share of GGD Stock
       as of such GSP Optional Exchange Announcement Date or (b) cash equal to
       the GSP Optional Exchange Amount, or (c) any combination of GGD Stock and
       cash equal to the GSP Optional Exchange Amount as determined by the Board
       of Directors.

                                      A-14
<PAGE>
           (2) If the Corporation receives an opinion of Qualified Tax Counsel
       that a Tax Event has occurred by reason of any Tax Law Change, then the
       Board of Directors may at any time declare that each of the outstanding
       shares of GSP Stock shall be exchanged, on an Exchange Date, as
       determined by the Board of Directors, for a number of fully paid and
       nonassessable shares of GGD Stock (calculated to the nearest five decimal
       places) equal to (1) the Fair Market Value of one share of the GSP Stock
       as of the date of the first public announcement by the Corporation of
       such exchange divided by (2) the Fair Market Value of one share of GGD
       Stock as of such date.

           (3) At any time at which all of the assets and liabilities attributed
       to Genzyme Surgical Products Division (and no other assets or liabilities
       of the Corporation or any subsidiary thereof) are held directly or
       indirectly by one or more wholly-owned subsidiaries of the Corporation
       (each, a "GSP Subsidiary"), the Board of Directors may, provided that
       there are funds of the Corporation legally available therefor, exchange
       on an Exchange Date, as determined by the Board of Directors, all of the
       outstanding shares of GSP Stock for that number of the shares of common
       stock of each GSP Subsidiary equal to the number of such GSP Subsidiary
       shares outstanding immediately prior to such exchange multiplied by the
       GSP Allocation Ratio, such shares of common stock of each GSP Subsidiary
       to be delivered to the holders of shares of GSP Stock on the Exchange
       Date either directly or indirectly through the delivery of shares of
       another GSP Subsidiary that owns directly or indirectly all such shares,
       and to be divided among the holders of GSP Stock on a pro rata basis in
       accordance with the number of shares of GSP Stock held by each such
       holder, each of which shares of common stock of such GSP Subsidiary shall
       be, upon such delivery, fully paid and nonassessable; PROVIDED, HOWEVER,
       that upon any such exchange, any existing GSP Designated Shares shall be
       cancelled in exchange for the allocation to Genzyme General of the direct
       or indirect interest of the Corporation in any remaining outstanding
       shares of each such GSP Subsidiary that are not transferred to the
       holders of GSP Stock in such exchange.

        (b)  MANDATORY EXCHANGE OR REDEMPTION OF OR PAYMENT OF DIVIDEND ON GSP
    STOCK.

           (1)  GSP MANDATORY PAYMENT.  In the event of the Disposition, in one
       transaction or a series of related transactions, by the Corporation
       and/or its subsidiaries of all or substantially all of the properties and
       assets allocated to Genzyme Surgical Products Division to any person,
       entity or group (other than a Disposition of a type set forth in
       subsection (2) of this subsection (b)), on or prior to the 60th Business
       Day, or such earlier date required under this Section IV.E.6, following
       the date of the GSP Mandatory Payment Announcement (as defined in
       Section IV.E.6(d)(2)), the Corporation shall select one of the following
       alternatives, as determined by the Board of Directors in its discretion:

               (A) provided that there are funds of the Corporation legally
           available therefor, pay to the holders of the shares of GSP Stock a
           dividend on a pro rata basis in accordance with the number of shares
           of GSP Stock held by each such holder in cash, securities (other than
           shares of a series of Common Stock) and/or other property having a
           Fair Market Value as of the date of the Disposition in the aggregate
           equal to the Fair Market Value as of the date of the Disposition of
           the GSP Net Proceeds of such Disposition; or

               (B) provided that there are funds of the Corporation legally
           available therefor,

                   (i) if such Disposition involves all (not merely
               substantially all) of the properties and assets attributed to
               Genzyme Surgical Products Division, redeem or exchange as of a
               Redemption Date determined by the Board of Directors, all
               outstanding shares of GSP Stock in exchange for, on a pro rata
               basis, cash securities (other than shares of a series of Common
               Stock) and/or other property having a Fair Market Value as of the
               date of the Disposition in the aggregate equal to the Fair Market
               Value as of the date of the Disposition of the GSP Net Proceeds
               of such Disposition; or

                                      A-15
<PAGE>
                   (ii) if such Disposition involves substantially all (but not
               all) of the properties and assets attributed to Genzyme Surgical
               Products Division, redeem or exchange as of a Redemption Date as
               determined by the Board of Directors such number of whole shares
               of GSP Stock (which may be all, but not more than all, of such
               shares outstanding) as have in the aggregate an average Closing
               Price during the period of ten (10) consecutive Business Days
               beginning on the first Business Day immediately following the
               date of the Estimated GSP Net Proceeds Announcement (as defined
               in Section IV.E.6(d)(2)) closest to the Fair Market Value as of
               the date of the Disposition of the GSP Net Proceeds of such
               Disposition in consideration for, on a pro rata basis, cash,
               securities (other than shares of a series of Common Stock) and/or
               other property having a Fair Market Value as of the date of the
               Disposition in the aggregate equal to such Fair Market Value of
               the GSP Net Proceeds; or

               (C) declare that each outstanding share of GSP Stock shall be
           exchanged as of an Exchange Date as determined by the Board of
           Directors into a number of fully paid and nonassessable shares of GGD
           Stock equal to 110% of the ratio (calculated to the nearest five
           decimal places) of the average Closing Price of one share of GSP
           Stock over the period of ten (10) consecutive Business Days beginning
           on the first Business Day immediately following the date of the
           Estimated GSP Net Proceeds Announcement (as defined in
           Section IV.E.6(d)(2)) to the average Closing Price of one share of
           GGD Stock over the same ten Business Day period.

Any redemption or exchange of or dividend payment on GSP Stock made pursuant to
this Section IV.E.6(b)(1) or Section IV.E.6(c)(3) is hereinafter referred to as
a "GSP Mandatory Payment." Notwithstanding the foregoing provisions of this
Section IV.E.6(b), the Corporation shall redeem GSP Stock as provided by
Section IV.E.(6)(b)(1) only if the amount to be paid pursuant to such redemption
is less than or equal to the Available GSP Dividend Amount as of the Redemption
Date.

           (2)  EXCEPTIONS TO MANDATORY PAYMENT.  Notwithstanding the foregoing
       Section IV.E.6(b)(1) or Section IV.E.6(c)(3), a GSP Mandatory Payment
       shall not be required by the occurrence of a Disposition:

                   (A) by the Corporation of all or substantially all of the
               Corporation's properties and assets in one transaction or a
               series of related transactions, including such Disposition in
               connection with the dissolution, liquidation or winding up of the
               Corporation and the distribution of assets to stockholders as
               referred to in Section IV.E.4;

                   (B) of the properties and assets attributed to Genzyme
               Surgical Products Division as contemplated by
               Section IV.E.6(a)(3) or otherwise to all holders of GSP Stock
               divided among such holders on a pro rata basis in accordance with
               the number of shares GSP Stock outstanding;

                   (C) to any person or entity controlled (as determined by the
               Board of Directors) by the Corporation;

                   (D) in connection with a Related Business Transaction in
               respect of Genzyme Surgical Products Division; or

                   (E) that is conditioned upon the affirmative vote of the
               holders of GSP Stock, voting as a separate class.

        (c)  TERMINATION OF CASH EXCHANGE RIGHT.  If the Corporation receives an
    opinion of Qualified Tax Counsel that, by reason of any Tax Law Change, the
    right or obligation of the Corporation to exchange GSP Stock for cash,
    securities or other property pursuant to Section IV.E.6(a)(1) or (3) or
    IV.E.6(b) (each, a "GSP Cash Exchange Right") would cause a Tax Event if not
    terminated, then the

                                      A-16
<PAGE>
    Board of Directors may at any time, by a vote of a majority of the directors
    then in office, elect to terminate any or all such GSP Cash Exchange Rights,
    with the result that the Corporation shall thereafter have, depending on
    which GSP Cash Exchange Right(s) is (are) so terminated:

               (1) under Section IV.E.6(a)(1) only the right to cause the
           exchange of GSP Stock for GGD Stock and not for cash, securities or
           other property other than capital stock of the Corporation,

               (2) no right to effect an exchange under Section IV.E.6(a)(3),
           and/or

               (3) no right or obligation to effect a GSP Mandatory Payment
           under Section IV.E.6(b), provided that if the Board shall no longer
           have the right or obligation to effect a GSP Mandatory Payment under
           Section IV.E.6(b), then if a GSP Mandatory Payment thereunder shall
           otherwise be or have been required, the Corporation instead shall
           have the obligation to effect on or prior to the first Business Day
           after the 90th day following the consummation of such Disposition, a
           GSP Mandatory Payment pursuant to which it shall exchange each
           outstanding share of GSP Stock for a number of fully paid and
           nonassessable shares of GGD Stock (calculated to the nearest five
           decimal places) equal to (i) the Fair Market Value of one share of
           the GSP Stock as of the date of the first public announcement of such
           Disposition by the Corporation by press release divided by (ii) the
           Fair Market Value of one share of GGD Stock as of such date.

    Notwithstanding the foregoing, the Board of Directors may not terminate any
GSP Cash Exchange Right during the period commencing on the date of a
Disposition requiring a GSP Mandatory Payment until the date upon which the
related Mandatory Payment is effected by the Corporation.

        (d)  EXCHANGE AND REDEMPTION PROCEDURES.

               (1) If the Corporation determines to exchange shares of GSP Stock
           pursuant to Section IV.E.6(a), the Corporation shall cause notice to
           be sent not less than 30 nor more than 60 days prior to the Exchange
           Date in the form and manner set forth in Section IV.G.1, and the
           procedures governing such exchange shall be those set forth in
           Section IV.G.1.

               (2) Not later than the 20th Business Day following the
           consummation of a Disposition described in Section IV.E.6(b)(1) with
           respect to Genzyme Surgical Products Division, the Corporation shall
           announce publicly by press release (1) the estimated GSP Net
           Proceeds, (2) the number of outstanding shares of GSP Stock and
           (3) the number of shares of GSP Stock into or for which Convertible
           Securities are then convertible, exchangeable or exercisable and the
           conversion, exchange or exercise price thereof (the "Estimated GSP
           Net Proceeds Announcement"). Not earlier than the day immediately
           following the 10th Business Day, nor later than the 20th Business
           Day, following the date of the Estimated GSP Net Proceeds
           Announcement, the Corporation shall announce publicly by press
           release which of the actions specified in Section IV.E.6(b)(1) that
           it has irrevocably determined to make in respect of such Disposition
           (the "GSP Mandatory Payment Announcement").

               (3) If the Corporation determines to pay a dividend pursuant to
           Section IV.E.6(b)(1)(A), the Corporation shall, not later than the
           20th Business Day following the date of the Estimated GSP Net
           Proceeds Announcement, cause notice to be sent to the holders of
           shares of GSP Stock and to each holder of Convertible Securities that
           are convertible into or exchangeable or exercisable for shares of GSP
           Stock (unless alternate provision for such notice to the holders of
           such Convertible Securities is made pursuant to the terms of such
           Convertible Securities), setting forth (1) the record date for
           determining holders entitled to receive such dividend, which shall be
           not earlier than the 10th Business Day and not later than the 20th
           Business Day following the date of such notice, (2) the anticipated
           payment date of such dividend (which shall not be more than 60
           Business Days

                                      A-17
<PAGE>
           following the date of the GSP Mandatory Payment Announcement),
           (3) the type and amount of property to be paid as such dividend in
           respect of the outstanding shares of GSP Stock, (4) the GSP Net
           Proceeds, (5) the number of outstanding shares of GSP Stock and the
           number of shares of GSP Stock into or for which outstanding
           Convertible Securities are then convertible, exchangeable or
           exercisable and the conversion, exchange or exercise price thereof
           and (6) in the case of notice to be given to holders of Convertible
           Securities, a statement to the effect that a holder of such
           Convertible Securities shall be entitled to receive such dividend
           only if such holder properly converts, exchanges or exercises such
           Convertible Securities (unless the terms of a Convertible Security
           provide otherwise) on or prior to the record date referred to in
           clause (1) of this sentence. Except as provided in the preceding
           sentence, such notice shall conform with the provisions governing
           notice at Section IV.G.1 and the provisions governing the payment of
           such dividend shall be those set for in such Section IV.G.1 to the
           extent such provisions are applicable to the payment of a dividend.

               (4) If the Corporation determines to redeem shares of GSP Stock
           pursuant to Section IV.E.6(b)(1)(B)(i), the Corporation shall, not
           later than the 20th Business Day following the date of the Estimated
           GSP Net Proceeds Announcement, cause notice to be sent in the form
           and manner set forth in Section IV.G.1, and the procedures governing
           such redemption shall be those set forth in Section IV.G.1; PROVIDED,
           HOWEVER, the Redemption Date shall not be more than 60 Business Days
           following the date of the GSP Mandatory Payment Announcement. Such
           notice shall also state the GSP Net Proceeds.

               (5) If the Corporation determines to redeem shares of GSP Stock
           pursuant to Section IV.E.6(b)(1)(B)(ii), the Corporation shall, not
           later than the 20th Business Day following the date of the GSP
           Estimated Net Proceeds Announcement, cause notice to be sent in the
           form and manner set forth in Section IV.G.1, and the procedures
           governing such redemption shall be those set forth in
           Section IV.G.1; PROVIDED, HOWEVER, the Redemption Date shall not be
           more than 60 Business Days following the date of the Estimated GSP
           Net Proceeds Announcement. The notice delivered hereunder shall also
           state (a) the GSP Net Proceeds and (b) a date (the "selection date")
           not earlier than the 10th Business Day and not later than the 20th
           Business Day following the date of such notice on which shares of GSP
           Stock shall be selected for redemption and that the Corporation will
           not be required to register a transfer of any shares of GSP Stock for
           a period of ten (10) Business Days next preceding the Selection Date.

               (6) If the Corporation determines to exchange GSP Stock for GGD
           Stock pursuant to Section IV.E.6(b)(1)(C), the Corporation shall
           cause notice to be sent in the form and manner set forth in
           Section IV.G.1, and the procedures governing such exchange shall be
           those set forth in Section IV.G.1; PROVIDED, HOWEVER, the Exchange
           Date shall not be more than 60 Business Days following the date of
           the GSP Mandatory Payment Announcement. Such notice shall also state
           the GSP Net Proceeds.

               (7) If the Corporation determines to exchange GSP Stock for GGD
           Stock pursuant to Section IV.E.6(c)(3), the Corporation shall cause
           notice to be sent not less than 30 nor more than 60 days in the form
           and manner set forth in Section IV.G.1, and the procedures governing
           such exchange shall be those set forth in Section IV.G.1.

        (e)  SPECIAL MANDATORY PAYMENT PROVISIONS.  For purposes of this
    Section IV.E.6:

               (1) "substantially all of the properties and assets allocated to
           Genzyme Surgical Products Division" shall mean a portion of the
           properties and assets allocated to Genzyme Surgical Products Division
           (A) that represents at least 80% of the then-current fair value (as
           determined by the Board of Directors) of, or (B) to which is
           attributable at least 80% of the

                                      A-18
<PAGE>
           aggregate revenues for the immediately preceding twelve fiscal
           quarterly periods of the Corporation derived from, the properties and
           assets allocated to Genzyme Surgical Products Division;

               (2) in the case of a Disposition of properties and assets in a
           series of related transactions, such Disposition shall not be deemed
           to have been consummated until the consummation of the last of such
           transactions; and

               (3) in the event that at the time of any Disposition there are
           outstanding any Convertible Securities convertible into or
           exercisable for shares of GSP Stock that would give the holders
           rights to receive any dividend related to the Disposition upon
           exercise, conversion or otherwise, or would adjust as a result of
           such dividend to give the holder equivalent economic rights, then the
           shares of GSP Stock underlying such Convertible Securities will be
           taken into account for purposes of computing the GSP Allocation Ratio
           and determining the terms of any dividend payment on such shares;

               (4) in the event that as a result of or in connection with a
           dividend payment pursuant to Section IV.E.6(b)(1)(A) there ceases to
           be any properties or assets attributed to Genzyme Surgical Products
           Division, then each outstanding share of GSP Stock shall immediately
           following such dividend payment be cancelled and all rights of a
           holder of a share of GSP Stock shall cease except for the right to
           such dividend payment; and

               (5) there shall be added to any cash portion of a GSP Mandatory
           Payment paid to holders of GSP Stock, which cash comprised a portion
           of the GSP Net Proceeds, any interest earned by Genzyme Surgical
           Products Division or the Corporation on such cash from the date of
           the Disposition up to the record date of such GSP Mandatory Payment.

    7.  DEFINITIONS.  As used in this Section IV.E., the following terms shall
have the following meanings (with terms defined in the singular having
comparable meaning when used in the plural and vice versa), unless another
definition is provided or the context otherwise requires. Capitalized terms used
but not defined in this Section IV.D.7 shall have the meanings given them in
Section IV.G.7.

        (a) "Available GSP Dividend Amount," on any date, shall mean the greater
    of:

           (1) the excess of

               (A) the greater of (x) the fair value on such date of the net
           assets of Genzyme Surgical Products Division and (y) an amount equal
           to $228,466,000 (division equity allocated to Genzyme Surgical
           Products Division at March 31, 1999), such dollar amount to be
           increased or decreased, as appropriate, to reflect, after March 31,
           1999, (A) the Earnings Attributable to Genzyme Surgical Products
           Division, (B) any dividends or other distributions (including by
           reclassification or exchange) declared or paid with respect to, or
           repurchases or issuances of, any shares of GSP Stock or any other
           class of capital stock attributed to Genzyme Surgical Products
           Division, but excluding dividends or other distributions paid in
           shares of GSP Stock to the holders thereof or in shares of any other
           class of capital stock attributed to Genzyme Surgical Products
           Division to the holders thereof, and (C) any other adjustments to the
           stockholders' equity of Genzyme Surgical Products Division made in
           accordance with generally accepted accounting principles, over

               (B) the sum of (x) the aggregate par value of all outstanding
           shares of GSP Stock and any other class of capital stock attributed
           to Genzyme Surgical Products Division and (y) unless these Articles
           of Organization permit otherwise, the aggregate amount that would be
           needed to satisfy any preferential rights to which holders of all
           outstanding Preferred Stock attributed to Genzyme Surgical Products
           Division are entitled upon dissolution of the Corporation in excess
           of the aggregate par value of such Preferred Stock, PROVIDED that
           such

                                      A-19
<PAGE>
           excess shall be reduced by any amount necessary to enable Genzyme
           Surgical Products Division to pay its debts as they become due, and

           (2) the amount legally available for the payment of dividends
       determined in accordance with Massachusetts law applied as if Genzyme
       Surgical Products Division were a separate corporation.

        (b) "Earnings Attributable" to Genzyme Surgical Products Division for
    any period shall mean the net income or loss of Genzyme Surgical Products
    Division for such period (or for the fiscal periods of the Corporation
    commencing prior to the GSP Effective Date and after March 31, 1999, pro
    forma net income or loss of Genzyme Surgical Products Division as if the GSP
    Effective Date were March 31, 1999) determined in accordance with generally
    accepted accounting principles, with all income and expenses of the
    Corporation being allocated between Divisions in a reasonable and consistent
    manner in accordance with policies adopted by the Board of Directors;
    PROVIDED, HOWEVER, that as of the end of any fiscal quarter of the
    Corporation, any projected annual tax benefit attributable to any Division
    that cannot be utilized by such Division to offset or reduce its allocated
    tax liability may be allocated to any other Division without any
    compensating payment or allocation.

        (c) "GSP Allocation Ratio," as of any date, shall mean the fraction
    computed by dividing the GSP Shares Outstanding by the sum of the GSP Shares
    Outstanding plus the GSP Designated Shares.

        (d) "GSP Designated Shares" as of any date shall mean a number of shares
    of GSP Stock that, as of the GSP Effective Date, shall be 16,000,000, which
    number shall be subject to adjustment as provided in the next sentence. The
    number of Genzyme Surgical Products Designated Shares shall from time to
    time be

           (1) adjusted as appropriate to reflect subdivisions (by stock split
       or otherwise) and combinations (by reverse stock split or otherwise) of
       the GSP Stock and dividends or distributions of shares of GSP Stock to
       holders of GSP Stock and other reclassifications of GSP Stock,

           (2) decreased by (A) the number of any shares of GSP Stock issued by
       the Corporation, the proceeds of which are allocated to Genzyme General
       Division, (B) the number of any shares of GSP Stock issued upon the
       exercise or conversion of Convertible Securities attributed to Genzyme
       General Division, and (C) the number of any shares of GSP Stock issued by
       the Corporation as a dividend or distribution or by reclassification,
       exchange or otherwise to holders of GGD Stock, and

           (3) increased by (A) the number of any outstanding shares of GSP
       Stock repurchased by the Corporation, the consideration for which was
       allocated to Genzyme General Division, (B) the number equal to the fair
       value (as determined by the Board of Directors) of assets or properties
       allocated to Genzyme General Division that are reallocated to Genzyme
       Surgical Products Division (other than reallocations that represent sales
       at fair value between such Divisions) divided by the Fair Market Value of
       one share of GSP Stock as of the date of such reallocation and (C) the
       number equal to (i) the aggregate Fair Market Value of any shares of GGD
       Stock issued to the limited partners of Genzyme Development Partners L.P.
       ("GDP") in connection with the Corporation's exercise on behalf of
       Genzyme Surgical Products Division of its purchase option to reacquire
       all of the limited partnership interests of GDP divided by (ii) the Fair
       Market Value of one share of GSP Stock as of the date of such exercise,

PROVIDED, that the Corporation shall take no action which would have the effect
of reducing the GSP Designated Shares to a number which is less than zero.
Within 45 days after the end of each fiscal quarter of the Corporation, the
Corporation shall prepare and file a statement of such change with the transfer
agent for the GSP Stock and with the Clerk of the Corporation.

        (e) "GSP Effective Date" shall mean June 10, 1999.

                                      A-20
<PAGE>
        (f) "GSP Net Proceeds" shall mean, as of any date, with respect to a
    Disposition of any of the properties and assets of Genzyme Surgical Products
    Division, a fraction of the proceeds from such disposition determined by
    multiplying the GSP Allocation Ratio by the gross proceeds of such
    Disposition after any adjustment to such gross proceeds resulting from
    payment of, or reasonable provision for, (a) any taxes payable by the
    Corporation in respect of either such Disposition or any mandatory exchange,
    redemption or dividend payment resulting from such Disposition (or that
    would have been payable but for the utilization of tax benefits attributable
    to any division or group of the Corporation other than Genzyme Surgical
    Products Division (a "Non-GSP Division")), (b) any transaction costs borne
    by a Non-GSP Division in connection with such Disposition, including,
    without limitation, any legal, investment banking and accounting fees and
    expenses borne by a Non-GSP Division in connection with such Disposition,
    (c) any liabilities and other obligations (contingent or otherwise) of
    Genzyme Surgical Products Division borne by a Non-GSP Division in connection
    with such Disposition, including, without limitation, any indemnity or
    guarantee obligations incurred by a Non-GSP Division in connection with the
    Disposition or any liabilities assumed by a Non-GSP Division for future
    purchase price adjustments, and (d) any preferential amounts, accumulated
    and unpaid dividends and other obligations in respect of any Preferred Stock
    attributed to Genzyme Surgical Products Division.

        (g) "GSP Shares Outstanding" as of any date shall mean the number of
    shares of GSP Stock then issued and outstanding.

        (h) "Genzyme Surgical Products Division" shall mean, at any time, the
    Corporation's interest in (i) surgical device, closure, instrument,
    biomaterial and biotherapeutic businesses, products, or development or
    research programs which exist as of the GSP Effective Date and are directed
    toward the cardiovascular, general and plastic surgery markets (other than
    such businesses, products, or development or research programs that were
    allocated to another division immediately prior to the GSP Effective Date);
    (ii) all assets and liabilities of the Corporation to the extent allocated
    to any such businesses, products, or development or research programs in
    accordance with generally accepted accounting principles consistently
    applied for all of the Corporation's business units; and (iii) such
    businesses, products, or development or research programs developed in, or
    acquired by the Corporation for, Genzyme Surgical Products Division after
    the GSP Effective Date, in each case as determined by the Board of
    Directors; PROVIDED, HOWEVER, that, from and after any Disposition or
    transfer to another Division of any business, product, development program,
    research project, assets or properties, Genzyme Surgical Products Division
    shall no longer include the business, product, development program, research
    project, assets or properties so disposed of or transferred. Genzyme
    Surgical Products Division shall be represented by the GSP Stock.

F.  GENZYME TISSUE REPAIR DIVISION COMMON STOCK

    1.  AUTHORIZED AMOUNTS AND DESIGNATIONS.  Forty million (40,000,000) shares
of Common Stock are designated as a series of Common Stock with the following
designation: Genzyme Tissue Repair Division Common Stock (the "GTR Stock"). To
the extent legally permitted, such number of shares may be increased or
decreased by vote of the Board of Directors, provided that no decrease shall
reduce the number of shares of GTR Stock to a number less than the number of
shares of such series then outstanding plus the number of shares of such series
reserved for issuance upon the exercise of outstanding options, rights or
warrants or upon the conversion of any outstanding securities issued by the
Corporation convertible into such series of Common Stock. A description of the
GTR Stock and a statement of its preferences, voting powers, qualifications and
special or relative rights or privileges is as follows:

    2.  DIVIDENDS AND DISTRIBUTIONS.  Subject to the express terms of any
outstanding series of Preferred Stock, dividends may be declared and paid upon
the GTR Stock, in such amounts and at such times as the Board of Directors may
determine, only out of the lesser of (a) funds of the Corporation legally
available therefor and (b) the Available GTR Dividend Amount.

                                      A-21
<PAGE>
    3.  VOTING RIGHTS.  The holders of GTR Stock, voting together with the
holders of shares of all other series of Common Stock as a single class of
stock, shall have the exclusive right to vote for the election of directors and
on all other matters requiring action by the stockholders or submitted to the
stockholders for action, except as may be determined by the Board of Directors
in establishing any series of Common or Preferred Stock or as may otherwise be
required by law. Each share of GTR Stock shall entitle the holder thereof to .06
vote through December 31, 2000. On January 1, 2001 and on each January 1 every
two years thereafter, the number of votes to which the holder of each share of
GTR Stock shall be entitled shall be adjusted and fixed for two-year periods to
equal the quotient (expressed as a decimal and rounded to the nearest two
decimal places) obtained by dividing (i) the Fair Market Value of one share of
GTR Stock by (ii) Fair Market Value of one share of GGD Stock as of such date.
If no shares of GGD Stock are outstanding on such date, then all other series of
voting Common Stock outstanding on such date shall have a number of votes such
that each share of the series of outstanding Common Stock that has the highest
Fair Market Value per share on such date (the "Base Series") shall have one vote
and each share of each other series of outstanding Common Stock shall have the
number of votes determined according to the immediately preceding sentence,
treating, for such purpose, the Base Series as the GGD Stock in such sentence.
If shares of GTR Stock are entitled to vote separately as a class, each share of
GTR Stock shall have one vote.

    4.  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any voluntary or
involuntary liquidation, dissolution or winding up of the Corporation, the
rights of the holders of GTR Stock shall be as follows:

        (a) After the Corporation has satisfied or made provision for its debts
    and obligations and for the payment to the holders of shares of any class or
    series of capital stock having preferential rights to receive distributions
    of the net assets of the Corporation (including any accumulated and unpaid
    dividends), the holders of GTR Stock shall be entitled to receive the net
    assets of the Corporation remaining for distribution, on a per share basis
    in proportion to the respective liquidation units per share of all series of
    Common Stock. Each share of GTR Stock shall, subject to Section G.4. below,
    have 58 liquidation units.

        (b) For the purposes of Section IV.D.3(a)., any merger or business
    combination involving the Corporation or any sale of all or substantially
    all of the assets of the Corporation shall not be treated as a liquidation.

    5.  SPECIAL VOTING RIGHTS.  The Corporation shall not, without approval by
the holders of the GTR Stock at a meeting at which a quorum is present and the
votes cast in favor of the proposal exceed those cast against:

        (a) allow any proceeds from the Disposition of the properties or assets
    allocated to Genzyme Tissue Repair Division to be used in the business of
    any other Division without fair compensation being allocated to Genzyme
    Tissue Repair Division as determined by the Board of Directors;

        (b) allow any properties or assets allocated to Genzyme Tissue Repair
    Division to be used in the business of any other Division or for the
    declaration or payment of any dividend or distribution on any series of
    Common Stock other than the GTR Stock without fair compensation being
    allocated to Genzyme Tissue Repair Division as determined by the Board of
    Directors;

        (c) issue, sell or otherwise distribute shares of GTR Stock without
    allocating the proceeds or other benefits of such issuance, sale or
    distribution to Genzyme Tissue Repair Division; provided, however, that the
    Corporation may without such approval issue GTR Designated Shares;

        (d) change the rights or preferences of the GTR Stock so as to affect
    the GTR Stock adversely; or

        (e) effect any merger or business combination involving the Corporation
    as a result of which (i) the holders of all series of Common Stock of the
    Corporation shall no longer own, directly or

                                      A-22
<PAGE>
    indirectly, at least fifty percent (50%) of the voting power of the
    surviving corporation and (ii) the holders of all series of Common Stock of
    the Corporation do not receive the same form of consideration, distributed
    among such holders in proportion to the Market Capitalization of each series
    of Common Stock as of the date of the first public announcement of such
    merger or business combination.

    Notwithstanding the foregoing, if the Corporation receives an opinion of
Qualified Tax Counsel that, by reason of any Tax Law Change, the special voting
rights of the GTR Stock set forth in this subsection 5 would cause a Tax Event
absent the termination of such rights, then the Corporation may, by vote of a
majority of the stock outstanding and entitled to vote thereon, voting together
as a single class, authorize an amendment to these Articles of Organization to
effect the termination of such rights in order to avoid the occurrence of such
Tax Event. Any such amendment shall not be deemed to change the rights or
preferences of the GTR Stock so as to affect the GSP Stock adversely as
contemplated by either Section IV.F.5(d) or Section 77 of the Massachusetts
Business Corporation Law.

    6.  EXCHANGE OR REDEMPTION OF GTR STOCK.  Shares of GTR Stock are subject to
exchange or redemption upon the terms and conditions set forth below:

        (a)  OPTIONAL EXCHANGE OF GTR STOCK.

           (1) The Board of Directors may at any time, including without
       limitation in the event of the reallocation, in one transaction or a
       series of related transactions, by the Corporation and/or its
       subsidiaries of all or substantially all of the properties and assets
       allocated to Genzyme Tissue Repair Division to any other Division of
       Genzyme, declare that each of the outstanding shares of GTR Stock shall
       be exchanged, on an Exchange Date, as determined by the Board of
       Directors, for (a) a number of fully paid and nonassessable shares of GGD
       Stock (calculated to the nearest five decimal places) equal to (1) 130%
       of the Fair Market Value of one share of the GTR Stock (the "GTR Optional
       Exchange Amount") as of the date of the first public announcement by the
       Corporation (the "GTR Optional Exchange Announcement Date") of such
       exchange divided by (2) the Fair Market Value of one share of GGD Stock
       as of such GTR Optional Exchange Announcement Date or (b) cash equal to
       the GTR Optional Exchange Amount, or (c) any combination of GGD Stock and
       cash equal to the GTR Optional Exchange Amount as determined by the Board
       of Directors.

           (2) If the Corporation receives an opinion of Qualified Tax Counsel
       that a Tax Event has occurred by reason of any Tax Law Change, then the
       Board of Directors may at any time declare that each of the outstanding
       shares of GTR Stock shall be exchanged, on an Exchange Date, as
       determined by the Board of Directors, for a number of fully paid and
       nonassessable shares of GGD Stock (calculated to the nearest five decimal
       places) equal to (1) the Fair Market Value of one share of the GTR Stock
       as of the date of the first public announcement by the Corporation of
       such exchange divided by (2) the Fair Market Value of one share of GGD
       Stock as of such date.

           (3) At any time at which all of the assets and liabilities attributed
       to Genzyme Tissue Repair Division (and no other assets or liabilities of
       the Corporation or any subsidiary thereof) are held directly or
       indirectly by one or more wholly-owned subsidiaries of the Corporation
       (each, a "GTR Subsidiary"), the Board of Directors may, provided that
       there are funds of the Corporation legally available therefor, exchange
       on an Exchange Date, as determined by the Board of Directors, all of the
       outstanding shares of GTR Stock for that number of the shares of common
       stock of each GTR Subsidiary equal to the number of such GTR Subsidiary
       shares outstanding immediately prior to such exchange multiplied by the
       GTR Allocation Ratio, such shares of common stock of each GTR Subsidiary
       to be delivered to the holders of shares of GTR Stock on the Exchange
       Date either directly or indirectly through the delivery of shares of
       another GTR Subsidiary that owns directly or indirectly all such shares,
       and to be divided among the holders of GTR Stock on a pro rata basis in
       accordance with the number of shares of GTR Stock held by

                                      A-23
<PAGE>
       each such holder, each of which shares of common stock of such GTR
       Subsidiary shall be, upon such delivery, fully paid and nonassessable;
       PROVIDED, HOWEVER, that upon any such exchange, any existing GTR
       Designated Shares shall be cancelled in exchange for the allocation to
       Genzyme General of the direct or indirect interest of the Corporation in
       any remaining outstanding shares of each such GTR Subsidiary that are not
       transferred to the holders of GTR Stock in such exchange.

        (b)  MANDATORY EXCHANGE OR REDEMPTION OF OR PAYMENT OF DIVIDEND ON GTR
    STOCK.

           (1)  GTR MANDATORY PAYMENT.  In the event of the Disposition, in one
       transaction or a series of related transactions, by the Corporation
       and/or its subsidiaries of all or substantially all of the properties and
       assets allocated to Genzyme Tissue Repair Division to any person, entity
       or group (other than a Disposition of a type set forth in subsection
       (2) of this subsection (b)), on or prior to the 60th Business Day, or
       such earlier date required under this Section IV.F.6, following the date
       of the GTR Mandatory Payment Announcement (as defined in
       Section IV.F.6(d)(2)), the Corporation shall select one of the following
       alternatives, as determined by the Board of Directors in its discretion:

               (A) provided that there are funds of the Corporation legally
           available therefor, pay to the holders of the shares of GTR Stock a
           dividend on a pro rata basis in accordance with the number of shares
           of GTR Stock held by each such holder in cash, in securities (other
           than shares of a series of Common Stock) and/or other property having
           a Fair Market Value as of the date of the Disposition in the
           aggregate equal to the Fair Market Value as of the date of the
           Disposition of the GTR Net Proceeds of such Disposition; or

               (B) provided that there are funds of the Corporation legally
           available therefor,

                   (i) if such Disposition involves all (not merely
               substantially all) of the properties and assets attributed to
               Genzyme Tissue Repair Division, redeem or exchange as of a
               Redemption Date determined by the Board of Directors, all
               outstanding shares of GTR Stock in exchange for, on a pro rata
               basis, cash, securities (other than shares of a series of Common
               Stock) and/or other property having a Fair Market Value as of the
               date of the Disposition in the aggregate equal to the Fair Market
               Value as of the date of the Disposition of the GTR Net Proceeds
               of such Disposition; or

                   (ii) if such Disposition involves substantially all (but not
               all) of the properties and assets attributed to Genzyme Tissue
               Repair Division, redeem or exchange as of a Redemption Date as
               determined by the Board of Directors such number of whole shares
               of GTR Stock (which may be all, but not more than all, of such
               shares outstanding) as have in the aggregate an average Closing
               Price during the period of ten (10) consecutive Business Days
               beginning on the first Business Day immediately following the
               date of the Estimated GTR Net Proceeds Announcement (as defined
               in Section IV.F.6(d)(2)) closest to the Fair Market Value as of
               the date of the Disposition of the GTR Net Proceeds of such
               Disposition in consideration for, on a pro rata basis, cash,
               securities (other than shares of a series of Common Stock), or
               other property having a Fair Market Value as of the date of the
               Disposition in the aggregate equal to such Fair Market Value of
               the GTR Net Proceeds; or

               (C) declare that each outstanding share of GTR Stock shall be
           exchanged as of an Exchange Date as determined by the Board of
           Directors into a number of fully paid and nonassessable shares of GGD
           Stock equal to 110% of the ratio (calculated to the nearest five
           decimal places) of the average Closing Price of one share of GTR
           Stock over the period of

                                      A-24
<PAGE>
           ten (10) consecutive Business Days beginning on the first Business
           Day immediately following the date of the Estimated GTR Net Proceeds
           Announcement (as defined in Section IV.F.6(d)(2)) to the average
           Closing Price of one share of GGD Stock over the same ten Business
           Day period.

Any redemption or exchange of or dividend payment on GTR Stock made pursuant to
this Section IV.F.6(b)(1) or Section IV.F.6(c)(3) is hereinafter referred to as
a "GTR Mandatory Payment." Notwithstanding the foregoing provisions of this
Section IV.F.6(b), the Corporation shall redeem GTR Stock as provided by
Section IV.F6(b)(1)(b) only if the amount to be paid pursuant to such redemption
is less than or equal to the Available GTR Dividend Amount as of the Redemption
Date.

           (2)  EXCEPTIONS TO MANDATORY PAYMENT.  Notwithstanding the foregoing
       Section IV.F.6(b)(1) or Section IV.F.6(c)(3), a GTR Mandatory Payment
       shall not be required by the occurrence of a Disposition:

           (A) by the Corporation of all or substantially all of the
       Corporation's properties and assets in one transaction or a series of
       related transactions, including such Disposition in connection with the
       dissolution, liquidation or winding up of the Corporation and the
       distribution of assets to stockholders as referred to in Section IV.F.4;

           (B) of the properties and assets attributed to Genzyme Tissue Repair
       Division as contemplated by Section IV.F.6(a)(3) or otherwise to all
       holders of GTR Stock divided among such holders on a pro rata basis in
       accordance with the number of shares GTR Stock outstanding;

           (C) to any person or entity controlled (as determined by the Board of
       Directors) by the Corporation;

           (D) in connection with a Related Business Transaction in respect of
       Genzyme Tissue Repair Division; or

           (E) that is conditioned upon the affirmative vote of the holders of
       GTR Stock, voting as a separate class.

        (c)  TERMINATION OF CASH EXCHANGE RIGHT.  If the Corporation receives an
    opinion of Qualified Tax Counsel that, by reason of any Tax Law Change, the
    right or obligation of the Corporation to exchange GTR Stock for cash,
    securities or other property pursuant to Section IV.F.6(a)(1) or (3) or
    IV.E.6(b) (each, a "GTR Cash Exchange Right") would cause a Tax Event if not
    terminated, then the Board of Directors may at any time, by a vote of a
    majority of the directors then in office, elect to terminate any or all such
    GTR Cash Exchange Rights, with the result that the Corporation shall
    thereafter have, depending on which GTR Cash Exchange Right(s) is (are) so
    terminated:

        (1) under Section IV.F.6(a)(1) only the right to cause the exchange of
    GTR Stock for GGD Stock and not for cash, securities or other property other
    than capital stock of the Corporation,

        (2) no right to effect an exchange under Section IV.F.6(a)(3), and/or

        (3) no right or obligation to effect a GTR Mandatory Payment under
    Section IV.F.6(b), provided that if the Board shall no longer have the right
    or obligation to effect a GTR Mandatory Payment under Section IV.F.6(b),
    then if a GTR Mandatory Payment thereunder shall otherwise be or have been
    required, the Corporation instead shall have the obligation to effect on or
    prior to the first Business Day after the 90th day following the
    consummation of such Disposition, a GTR Mandatory Payment pursuant to which
    it shall exchange each outstanding share of GTR Stock for a number of fully
    paid and nonassessable shares of GGD Stock (calculated to the nearest five
    decimal places) equal to (i) the Fair Market Value of one share of the GTR
    Stock as of the date of the first public announcement of such Disposition by
    the Corporation by press release divided by (ii) the Fair Market Value of
    one share of GGD Stock as of such date.

                                      A-25
<PAGE>
    Notwithstanding the foregoing, the Board of Directors may not terminate any
GTR Cash Exchange Right during the period commencing on the date of a
Disposition requiring a GTR Mandatory Payment until the date upon which the
related Mandatory Payment is effected by the Corporation.

        (d)  EXCHANGE AND REDEMPTION PROCEDURES.

        (1) If the Corporation determines to exchange shares of GTR Stock
    pursuant to Section IV.F.6(a), the Corporation shall cause notice to be sent
    not less than 30 nor more than 60 days prior to the Exchange Date in the
    form and manner set forth in Section IV.G.1, and the procedures governing
    such exchange shall be those set forth in Section IV.G.1.

        (2) Not later than the 20th Business Day following the consummation of a
    Disposition described in Section IV.F.6(b)(1) with respect to Genzyme Tissue
    Repair Division, the Corporation shall announce publicly by press release
    (1) the estimated GTR Net Proceeds, (2) the number of outstanding shares of
    GTR Stock and (3) the number of shares of GTR Stock into or for which
    Convertible Securities are then convertible, exchangeable or exercisable and
    the conversion, exchange or exercise price thereof (the "Estimated GTR Net
    Proceeds Announcement"). Not earlier than the day immediately following the
    10th Business Day, nor later than the 20th Business Day, following the date
    of the Estimated GTR Net Proceeds Announcement, the Corporation shall
    announce publicly by press release which of the actions specified in
    Section IV.F.6(b)(1) that it has irrevocably determined to make in respect
    of such Disposition (the "GTR Mandatory Payment Announcement").

        (3) If the Corporation determines to pay a dividend pursuant to
    Section IV.F.6(b)(1)(A), the Corporation shall, not later than the 20th
    Business Day following the date of the Estimated GTR Net Proceeds
    Announcement, cause notice to be sent to the holders of shares of GTR Stock
    and to each holder of Convertible Securities that are convertible into or
    exchangeable or exercisable for shares of GTR Stock (unless alternate
    provision for such notice to the holders of such Convertible Securities is
    made pursuant to the terms of such Convertible Securities), setting forth
    (1) the record date for determining holders entitled to receive such
    dividend, which shall be not earlier than the 10th Business Day and not
    later than the 20th Business Day following the date of such notice, (2) the
    anticipated payment date of such dividend (which shall not be more than 60
    Business Days following the date of the GTR Mandatory Payment Announcement),
    (3) the type and amount of property to be paid as such dividend in respect
    of the outstanding shares of GTR Stock, (4) the GTR Net Proceeds, (5) the
    number of outstanding shares of GTR Stock and the number of shares of GTR
    Stock into or for which outstanding Convertible Securities are then
    convertible, exchangeable or exercisable and the conversion, exchange or
    exercise price thereof and (6) in the case of notice to be given to holders
    of Convertible Securities, a statement to the effect that a holder of such
    Convertible Securities shall be entitled to receive such dividend only if
    such holder properly converts, exchanges or exercises such Convertible
    Securities (unless the terms of a Convertible Security provide otherwise) on
    or prior to the record date referred to in clause (1) of this sentence.
    Except as provided in the preceding sentence, such notice shall conform with
    the provisions governing notice at Section IV.G.1 and the provisions
    governing the payment of such dividend shall be those set for in such
    Section IV.G.1 to the extent such provisions are applicable to the payment
    of a dividend.

        (4) If the Corporation determines to redeem shares of GTR Stock pursuant
    to Section IV.F.6(b)(1)(B)(i), the Corporation shall, not later than the
    20th Business Day following the date of the Estimated GTR Net Proceeds
    Announcement, cause notice to be sent in the form and manner set forth in
    Section IV.G.1, and the procedures governing such redemption shall be those
    set forth in Section IV.G.1; PROVIDED, HOWEVER, the Redemption Date shall
    not be more than 60 Business Days following the date of the GTR Mandatory
    Payment Announcement. Such notice shall also state the GTR Net Proceeds.

        (5) If the Corporation determines to redeem shares of GTR Stock pursuant
    to Section IV.F.6(b)(1)(B)(ii), the Corporation shall, not later than the
    20th Business Day following the date

                                      A-26
<PAGE>
    of the GTR Estimated Net Proceeds Announcement, cause notice to be sent in
    the form and manner set forth in Section IV.G.1, and the procedures
    governing such redemption shall be those set forth in Section IV.G.1;
    PROVIDED, HOWEVER, the Redemption Date shall not be more than 60 Business
    Days following the date of the Estimated GTR Net Proceeds Announcement. The
    notice delivered hereunder shall also state (a) the GTR Net Proceeds and
    (b) a date (the "selection date") not earlier than the 10th Business Day and
    not later than the 20th Business Day following the date of such notice on
    which shares of GTR Stock shall be selected for redemption and that the
    Corporation will not be required to register a transfer of any shares of GTR
    Stock for a period of ten (10) Business Days next preceding the Selection
    Date.

        (6) If the Corporation determines to exchange GTR Stock for GGD Stock
    pursuant to Section IV.F.6(b)(1)(C), the Corporation shall cause notice to
    be sent in the form and manner set forth in Section IV.G.1, and the
    procedures governing such exchange shall be those set forth in
    Section IV.G.1; PROVIDED, HOWEVER, the Exchange Date shall not be more than
    60 Business Days following the date of the GTR Mandatory Payment
    Announcement. Such notice shall also state the GTR Net Proceeds.

        (7) If the Corporation determines to exchange GTR Stock for GGD Stock
    pursuant to Section IV.F.6(c)(3), the Corporation shall cause notice to be
    sent not less than 30 nor more than 60 days in the form and manner set forth
    in Section IV.G.1, and the procedures governing such exchange shall be those
    set forth in Section IV.G.1.

        (e)  SPECIAL MANDATORY PAYMENT PROVISIONS.  For purposes of this
    Section IV.F.6:

        (1) "substantially all of the properties and assets allocated to Genzyme
    Tissue Repair Division" shall mean a portion of the properties and assets
    allocated to Genzyme Tissue Repair Division (A) that represents at least 80%
    of the then-current fair value (as determined by the Board of Directors) of,
    or (B) to which is attributable at least 80% of the aggregate revenues for
    the immediately preceding twelve fiscal quarterly periods of the Corporation
    derived from, the properties and assets allocated to Genzyme Tissue Repair
    Division;

        (2) in the case of a Disposition of properties and assets in a series of
    related transactions, such Disposition shall not be deemed to have been
    consummated until the consummation of the last of such transactions; and

        (3) in the event that at the time of any Disposition there are
    outstanding any Convertible Securities convertible into or exercisable for
    shares of GTR Stock that would give the holders rights to receive any
    dividend related to the Disposition upon exercise, conversion or otherwise,
    or would adjust as a result of such dividend to give the holder equivalent
    economic rights, then the shares of GTR Stock underlying such Convertible
    Securities will be taken into account for purposes of computing the GTR
    Allocation Ratio and determining the terms of any dividend payment on such
    shares;

        (4) in the event that as a result of or in connection with a dividend
    payment pursuant to Section IV.F.6(b)(1)(A) there ceases to be any
    properties or assets attributed to Genzyme Tissue Repair Division, then each
    outstanding share of GTR Stock shall immediately following such dividend
    payment be cancelled and all rights of a holder of a share of GTR Stock
    shall cease except for the right to such dividend payment; and

        (5) there shall be added to any cash portion of a GTR Mandatory Payment
    paid to holders of GTR Stock, which cash comprised a portion of the GTR Net
    Proceeds, any interest earned by Genzyme Tissue Repair Division or the
    Corporation on such cash from the date of the Disposition up to the record
    date of such GTR Mandatory Payment.

    7.  DEFINITIONS.  As used in this Section IV.F., the following terms shall
have the following meanings (with terms defined in the singular having
comparable meaning when used in the plural and vice versa),

                                      A-27
<PAGE>
unless another definition is provided or the context otherwise requires.
Capitalized terms used but not defined in this Section IV.F.7 shall have the
meanings given them in Section IV.G.7.

           (a) "Available GTR Dividend Amount," on any date, shall mean the
       greater of:

               (1) the excess of

                   (A) the greater of (x) the fair value on such date of the net
               assets of Genzyme Tissue Repair Division and (y) an amount equal
               to $28,712,000 (stockholders' equity allocated to Genzyme Tissue
               Repair Division at June 30, 1994), such dollar amount to be
               increased or decreased, as appropriate, to reflect, after
               June 30, 1994, (A) the Earnings Attributable to Genzyme Tissue
               Repair Division, (B) any dividends or other distributions
               (including by reclassification or exchange) declared or paid with
               respect to, or repurchases or issuances of, any shares of GTR
               Stock or any other class of capital stock attributed to Genzyme
               Tissue Repair Division, but excluding dividends or other
               distributions paid in shares of GTR Stock to the holders thereof
               or in shares of any other class of capital stock attributed to
               Genzyme Tissue Repair Division to the holders thereof, and
               (C) any other adjustments to the stockholders' equity of Genzyme
               Tissue Repair Division made in accordance with generally accepted
               accounting principles, over

                   (B) the sum of (x) the aggregate par value of all outstanding
               shares of GTR Stock and any other class of capital stock
               attributed to Genzyme Tissue Repair Division and (y) unless these
               Articles of Organization permit otherwise, the aggregate amount
               that would be needed to satisfy any preferential rights to which
               holders of all outstanding Preferred Stock attributed to Genzyme
               Tissue Repair Division are entitled upon dissolution of the
               Corporation in excess of the aggregate par value of such
               Preferred Stock, provided that such excess shall be reduced by
               any amount necessary to enable Genzyme Tissue Repair Division to
               pay its debts as they become due, and

               (2) the amount legally available for the payment of dividends
           determined in accordance with Massachusetts law applied as if Genzyme
           Tissue Repair Division were a separate corporation.

           (b) "Earnings Attributable" to Genzyme Tissue Repair Division for any
       period, shall mean the net income or loss of Genzyme Tissue Repair
       Division for such period (or for the fiscal periods of the Corporation
       commencing prior to the GTR Effective Date and after June 30, 1994, pro
       forma net income or loss of Genzyme Tissue Repair Division as if the GTR
       Effective Date were June 30, 1994) determined in accordance with
       generally accepted accounting principles, with all income and expenses of
       the Corporation being allocated between Divisions in a reasonable and
       consistent manner in accordance with policies adopted by the Board of
       Directors; provided, however, that as of the end of any fiscal quarter of
       the Corporation, any projected annual tax benefit attributable to any
       Division that cannot be utilized by such Division to offset or reduce its
       allocated tax liability may be allocated to any other Division without
       any compensating payment or allocation.

           (c) "GTR Allocation Ratio," as of any date, shall mean the fraction
       computed by dividing the GTR Shares Outstanding by the sum of the GTR
       Shares Outstanding plus the GTR Designated Shares.

           (d) "GTR Effective Date" shall mean December 16, 1994.

           (e) "GTR Net Proceeds" shall mean, as of any date, with respect to a
       Disposition of any of the properties and assets of Genzyme Tissue Repair
       Division, a fraction of the proceeds from such disposition determined by
       multiplying the GTR Allocation Ratio by the gross proceeds of such
       Disposition after any adjustment to such gross proceeds resulting from
       payment of, or

                                      A-28
<PAGE>
       reasonable provision for, (a) any taxes payable by the Corporation in
       respect of either such Disposition or any mandatory exchange, redemption
       or dividend payment resulting from such Disposition (or that would have
       been payable but for the utilization of tax benefits attributable to any
       division or group of the Corporation other than Genzyme Tissue Repair
       Division (a "Non-GTR Division")), (b) any transaction costs borne by a
       Non-GTR Division in connection with such Disposition, including, without
       limitation, any legal, investment banking and accounting fees and
       expenses borne by a Non-GTR Division in connection with such Disposition,
       (c) any liabilities and other obligations (contingent or otherwise) of
       Genzyme Tissue Repair Division borne by a Non-GTR Division in connection
       with such Disposition, including, without limitation, any indemnity or
       guarantee obligations incurred by a Non-GTR Division in connection with
       the Disposition or any liabilities assumed by a Non-GTR Division for
       future purchase price adjustments, and (d) any preferential amounts,
       accumulated and unpaid dividends and other obligations in respect of any
       Preferred Stock attributed to Genzyme Tissue Repair Division.

           (f) "GTR Shares Outstanding" as of any date shall mean the number of
       shares of GTR Stock then issued and outstanding.

           (g) "Genzyme Tissue Repair Division" shall mean, at any time, the
       Corporation's interest in (i) the following businesses, products, or
       development or research programs: (A) Vianain-Registered Trademark- for
       debridement of necrotic or damaged tissue; (B) TGF-B2 for all indications
       licensed from Celtrix Pharmaceuticals, Inc. on the GTR Effective Date;
       (C) Epicel-TM- cultured epithelial cell autografts for tissue replacement
       or repair, including but not limited to skin, ocular or oral tissue;
       (D) Acticel-TM- cultured epithelial cell allografts for tissue
       replacement or repair, including but not limited to skin, ocular or oral
       tissue; (E) Chondrograft cultured chondrocyte auto- and allografts;
       (F) tissue-type plasminogen activator ("tPA") for all tissue repair
       indications licensed by the Corporation from Genentech, Inc. on the GTR
       Effective Date; (G) the leukocyte-derived growth factor ("LDGF") research
       program; (H) the dermal replacement research program; (I) the cultured
       fibroblast dermal replacement research program and (J) the research
       program on cultured keratinocyte or fibroblast cell extracts or
       derivatives, each as being conducted by the Corporation on the GTR
       Effective Date; (ii) all assets and liabilities of the Corporation to the
       extent allocated to any such businesses, products, or development or
       research programs in accordance with generally accepted accounting
       principles consistently applied for all of the Corporation's business
       units; and (iii) such businesses, products, or development or research
       programs developed in, or acquired by the Corporation for, Genzyme Tissue
       Repair Division after the GTR Effective Date, in each case as determined
       by the Board of Directors; provided, however, that, from and after any
       Disposition or transfer to Genzyme General Division of any business,
       product, development or research program, assets or properties, Genzyme
       Tissue Repair Division shall no longer include the business, product,
       development program, research project, assets or properties so disposed
       of or transferred. Genzyme Tissue Repair Division shall be represented by
       the GTR Stock.

           (h) "GTR Designated Shares" as of any date shall mean a number of
       shares of GTR Stock that shall initially be 5,000,000, which number shall
       be subject to adjustment as provided in the next sentence. The number of
       GTR Designated Shares shall from time to time be

               (1) adjusted as appropriate to reflect subdivisions (by stock
           split or otherwise) and combinations (by reverse stock split or
           otherwise) of the GTR Stock and dividends or distributions of shares
           of GTR Stock to holders of GTR Stock and other reclassifications of
           GTR Stock,

               (2) decreased by (A) the number of any shares of GTR Stock issued
           by the Corporation, the proceeds of which are allocated to Genzyme
           General Division, (B) the number of any shares of GTR Stock issued
           upon the exercise or conversion of Convertible Securities

                                      A-29
<PAGE>
           attributed to Genzyme General Division, and (C) the number of any
           shares of GTR Stock issued by the Corporation as a dividend or
           distribution or by reclassification, exchange or otherwise to holders
           of GGD Stock, and

               (3) increased by (A) the number of any outstanding shares of GTR
           Stock repurchased by the Corporation, the consideration for which was
           allocated to Genzyme General Division, (B) one for each $10.00
           reallocated from Genzyme General Division to Genzyme Tissue Repair
           Division from time to time in satisfaction of the funding commitment
           or the purchase option of Genzyme General Division set forth in
           sections 4.17 and 4.18 of the Agreement and Plan of Reorganization
           among the Corporation, Phoenix Acquisition Corporation and BioSurface
           Technology, Inc. dated as of July 25, 1994, up to a maximum of
           $30,000,000, and (C) the number equal to the fair value (as
           determined by the Board of Directors) of assets or properties
           allocated to Genzyme General Division that are reallocated to Genzyme
           Tissue Repair Division (other than reallocations that represent sales
           at fair value between such Divisions or reallocations described in
           the foregoing clause (B)) divided by the Fair Market Value of one
           share of GTR Stock as of the date of such reallocation;

PROVIDED, that the Corporation shall take no action which would have the effect
of reducing the GTR Designated Shares to a number which is less than zero.
Within 45 days after the end of each fiscal quarter of the Corporation, the
Corporation shall prepare and file a statement of such change with the transfer
agent for the GTR Stock and with the Clerk of the Corporation.

G. GENERAL PROVISIONS REGARDING THE COMMON STOCK

    1.  GENERAL EXCHANGE AND REDEMPTION PROVISIONS.  In the event of any
exchange or mandatory redemption or dividend pursuant to the provisions of these
Articles of Organization, the following provisions shall apply:

        (a) Any notice delivered hereunder shall be sent by the Corporation to
    each record holder of shares of the Common Stock to be exchanged or redeemed
    or upon which will be made a dividend payment (the "Exchange Stock") and to
    the holders of Convertible Securities that are convertible into or
    exchangeable or exercisable for shares of such Exchange Stock (unless
    alternate provision for such notice is made pursuant to the terms of such
    Convertible Securities). Unless otherwise required by any other provision of
    these Articles of Organization, such notice shall be sent not less nor more
    than 60 days prior to the Exchange Date.

        (b) With respect to an exchange or redemption, such notice shall state,
    to the extent and in the manner applicable, (1) the number of shares of
    Exchange Stock outstanding on the record date for such exchange or
    redemption and the number of such shares to be redeemed or exchanged,
    (2) the aggregate amount and form of consideration, including shares of
    Common Stock, other securities, cash or other property, that will be paid on
    the Exchange Date or Redemption Date upon the exchange or redemption of the
    shares of Exchange Stock, (3) the amount and form of such consideration to
    be received by such holder with respect to each share of the Exchange Stock
    held by such holder, including details as to the calculation thereof,
    (4) the Exchange Date or Redemption Date, (5) the place or places where
    certificates for shares of Exchange Stock, properly endorsed or assigned for
    transfer are to be surrendered for delivery of such consideration (unless
    the Corporation shall waive such requirement), (6), if applicable, a
    statement to the effect that, subject to Section IV.G.1(e) dividends on
    shares of Exchange Stock shall cease to be paid as of such Exchange Date or
    Redemption Date, (7) the number of shares of Exchange Stock into or for
    which outstanding Convertible Securities are convertible, exchangeable or
    exercisable as of the record date for such exchange or redemption and the
    conversion, exchange or exercise price thereof and (8) in the case of notice
    to holders of Convertible Securities, a statement to the effect that a
    holder of Convertible Securities shall be entitled to receive its pro rata
    portion of the consideration, as applicable, upon

                                      A-30
<PAGE>
    redemption or exchange only if such holder properly converts, exchanges or
    exercises such Convertible Securities (unless the terms of a Convertible
    Security provide otherwise) on or prior to the Exchange Date or Redemption
    Date and a statement as to what, if anything, such holder will be entitled
    to receive pursuant to the terms of such Convertible Securities if such
    holder thereafter converts, exchanges or exercises such Convertible
    Securities.

        (c) Any notice delivered under this Section IV.G.1 shall be sent by
    first-class mail, postage prepaid at such holder's address as the same
    appears on the stock transfer books of the Corporation. Neither the failure
    to mail such notice to any particular holder of shares of Exchange Stock nor
    any defect therein shall affect the sufficiency thereof with respect to any
    other holder of shares of Exchange Stock or the validity of any such
    exchange, redemption or dividend payment.

        (d) The Corporation shall not be required to issue or deliver fractional
    shares of any series of Common Stock, capital stock, securities or other
    property to any holder of shares of Exchange Stock upon any such exchange,
    redemption or dividend payment. If more than one share of Exchange Stock
    shall be held by the same holder of record, the Corporation shall aggregate
    the number of shares of any security that shall be issuable or any other
    property that shall be distributable to such holder upon any such exchange,
    redemption or dividend payment. If fractional shares of any security would
    be required to be issued or distributed to the holder of Exchange Stock, the
    Corporation shall, if such fractional shares are not issued or distributed
    to such holder, either arrange for the disposition of such fraction by or on
    behalf of such holder or pay the Fair Market Value (without interest) of
    such fractional shares.

        (e) No adjustments in respect of dividends shall be made upon the
    exchange or redemption of any shares of Exchange Stock; provided, however,
    that if the Exchange Date shall be subsequent to the record date for
    determining holders of Exchange Stock entitled to the payment of a dividend
    or other distribution thereon or with respect thereto, the holders of shares
    of Exchange Stock at the close of business on such record date shall be
    entitled to receive the dividend or other distribution payable on or with
    respect to such shares on the date set for payment of such dividend or other
    distribution, notwithstanding the exchange or redemption of such shares.

        (f) With respect to an exchange or redemption, before any holder of
    shares of Exchange Stock shall be entitled to receive the consideration to
    be received by such holder with respect to the exchange or redemption of
    such shares of Exchange Stock, such holder shall surrender at such place as
    the Corporation shall specify certificates for such shares of Exchange
    Stock, properly endorsed or assigned for transfer (unless the Corporation
    shall waive such requirement). The Corporation will as soon as practicable
    after such surrender of certificates representing such shares of Exchange
    Stock deliver to the person for whose account such shares of Exchange Stock
    were so surrendered, or to the nominee or nominees of such person, the
    consideration to which such person shall be entitled as aforesaid, together
    with any fractional share payment contemplated by Section IV.G.1(d).

        (g) With respect to an exchange or redemption, from and after the
    Exchange Date, all rights of a holder of shares of Exchange Stock shall
    cease except for the right, upon surrender of the certificates representing
    such shares of Exchange Stock, to receive the consideration for which such
    shares were exchanged are redeemed, together with any fractional share
    payment contemplated by Section IV.G.1(d), and rights to dividends as
    provided in Section IV.G.1(e). No holder of a certificate that immediately
    prior to the Exchange Date represented shares of Exchange Stock shall be
    entitled to receive any dividend or interest payment or other distribution
    with respect to the shares of any security or instrument for which the
    Exchange Stock was exchanged or redeemed until surrender of such holder's
    certificate for a certificate or certificates or instrument or instruments
    representing such security (unless the Corporation shall waive such
    requirement). Subject to applicable escheat and similar laws, upon such
    surrender, there shall be paid to the holder the amount of any dividend or
    interest payments or other distributions (without interest) which
    theretofore became payable with

                                      A-31
<PAGE>
    respect to a record date after the Exchange Date, but that were not paid by
    reason of the foregoing, with respect to the number of shares of the kind of
    securities represented by the certificate or certificates issued upon such
    surrender. From and after the Exchange Date, the Corporation shall, however,
    be entitled to treat the certificates for Exchange Stock that have not yet
    been surrendered for exchange or redemption as evidencing the ownership of
    the number of shares of the kind of securities for which the shares of
    Exchange Stock represented by such certificates shall have been exchanged or
    redeemed, notwithstanding the failure to surrender such certificates.

        (h) The Corporation will pay any and all documentary, stamp or similar
    issue or transfer taxes that may be payable in respect of the issue or
    delivery of any securities in exchange for or upon redemption of or dividend
    payment on shares of Exchange Stock pursuant hereto. The Corporation shall
    not, however, be required to pay any tax that may be payable in respect of
    any transfer involved in the issue and delivery of any such securities
    issued in exchange or upon redemption or as a dividend in a name other than
    that in which the shares of Exchange Stock so exchanged or redeemed or paid
    as a dividend upon were registered and no such issue or delivery shall be
    made unless and until the person requesting such issue has paid to the
    Corporation the amount of any such tax, or has established to the
    satisfaction of the Corporation that such tax has been paid or that no such
    tax is due.

        (i) After the Exchange Date, any share of Exchange Stock issued upon
    conversion or exercise of any Convertible Security shall, immediately upon
    issuance pursuant to such conversion or exercise and without any notice or
    any other action on the part of the Corporation or its Board of Directors or
    the holder of such share of Exchange Stock, be exchanged for the amount of
    cash, securities and/or other property thereof (together with any payments
    in lieu of fractional shares or dividends, if any) that a holder of such
    Convertible Security would have been entitled to receive pursuant to the
    terms of such Convertible Security had such terms provided that the
    conversion privilege in effect immediately prior to any exchange by the
    Corporation of any shares of Exchange Stock would be adjusted so that the
    holder of any such Convertible Security thereafter surrendered for
    conversion would be entitled to receive the amount of cash, securities
    and/or other property he or she would have owned immediately following such
    action had such Convertible Security been converted immediately prior to
    such exchange. The foregoing provisions shall not apply to the extent that
    equivalent adjustments are otherwise made pursuant to the provisions of such
    Convertible Security.

    2.  VOTING OF CONTROLLED SHARES.  Shares of any series of Common Stock held
by a corporation or other entity controlled by the Corporation (other than an
employee benefit plan) shall be voted on any proposal requiring a vote of the
holders of such series in the same proportion as votes are cast for or against
such proposal by all other holders of such series.

    3.  DISCRIMINATION BETWEEN CLASSES OF COMMON STOCK.  Subject to the
provisions of each series of Common Stock regarding the payment of dividends on
such series of Common Stock, the Board of Directors may, in its sole discretion,
declare and pay dividends exclusively on any series of Common Stock, or all
series, in equal or unequal amounts, notwithstanding the amounts available for
the payment of dividends on any series, the respective voting and liquidation
rights of each series, the amounts of prior dividends declared on each series or
any other factor.

    4.  ADJUSTMENTS RELATIVE TO VOTING RIGHTS AND LIQUIDATION.  If at any time
the Corporation shall in any manner subdivide (by stock split, reclassification
or otherwise) or combine (by reverse stock split, reclassification or otherwise)
the outstanding shares of any series of Common Stock, or pay a dividend or make
a distribution in shares of any series of Common Stock to holders of such
series, the per share voting rights and the liquidation units of each series of
Common Stock other than the GGD Stock shall be appropriately adjusted so as to
avoid dilution in the aggregate voting and liquidation rights of any series. The
issuance by the Corporation of shares of any series of Common Stock (whether by
a dividend or otherwise) to the holders of any other series of Common Stock
shall not require adjustment pursuant to this paragraph.

                                      A-32
<PAGE>
    5.  RANK.  All series of Common Stock shall rank junior with respect to the
payment of dividends and the distribution of assets to all series of the
Corporation's Preferred Stock that specifically provide that they shall rank
prior to the Common Stock. Nothing herein shall preclude the Board from creating
any series of Preferred Stock ranking on a parity with or prior to the Common
Stock as to the payment of dividends or the distribution of assets.

    6.  FRACTIONAL SHARES.  Any series of Common Stock may be issued in
fractions of a share which shall entitle the holder, in proportion to such
holder's fractional shares, to exercise voting rights, receive dividends,
participate in distributions and to have the benefit of all other rights of
holders of such series of Common Stock.

    7.  DEFINITIONS.  As used in these Articles of Organization, the following
terms shall have the following meanings (with terms defined in the singular
having comparable meaning when used in the plural and vice versa), unless
another definition is provided or the context otherwise requires:

        (a) "Business Day" shall mean each weekday other than any day on which
    any relevant series of common stock is not traded on any national securities
    exchange or the Nasdaq National Market or in the over-the-counter market.

        (b) The "Closing Price," with respect to any security, as of any given
    day, shall be (x) if such security is listed or admitted to trading on a
    national securities exchange, the closing price on the New York Stock
    Exchange Composite Tape (or any successor composite tape reporting
    transactions on national securities exchanges) or, if such composite tape
    shall not be in use or shall not report transactions in such shares, the
    last reported sales price regular way on the principal national securities
    exchange on which such shares are listed or admitted to trading (which shall
    be the national securities exchange on which the greatest number of shares
    of such series of stock has been traded during such consecutive trading
    days), or, if there is no such sale on any such day, the mean of the bid and
    asked prices on such day, or (y) if such shares are not listed or admitted
    to trading on any such exchange, the closing price, if reported, or, if the
    closing price is not reported, the mean of the closing bid and asked prices
    as reported by the Nasdaq National Market or a similar source selected from
    time to time by the Corporation for the purpose.

        (c) "Convertible Securities" shall mean any securities (including
    employee stock options) of the Corporation that are convertible into or
    evidence the right to purchase any shares of any series of Common Stock.

        (d) "Disposition" shall mean the sale, transfer, assignment or other
    disposition (whether by merger, consolidation, sale or contribution of
    assets or stock or otherwise) of any properties or assets, other than by
    pledge, hypothecation or grant of any security interest in such properties
    or assets.

        (e) "Exchange Date" shall mean, in respect of any exchange of any share
    of a series of Common Stock effected pursuant to these Articles of
    Organization, the date upon which such exchange becomes effective.

        (f) "Fair Market Value" shall mean

           (1) as to shares of any series of stock of the Corporation as of any
       date, the average of the daily Closing Prices for the 20 consecutive
       Business Days commencing on the 30th Business Day prior to such date,
       except that in the event such Closing Prices are unavailable, Fair Market
       Value shall be determined by the Board of Directors;

           (2) in the case of securities other than securities of the
       Corporation, if such security of a class that has previously been
       publicly traded for a period of at least three months, the Market Value
       thereof or, in the case of a security that has not been publicly traded
       for at least such period, the fair value per share of stock or per other
       unit of such security, on a fully distributed

                                      A-33
<PAGE>
       basis, as determined by an independent investment banking firm
       experienced in the valuation of securities selected in good faith by the
       Board of Directors;

           (3) in the case of property other than securities, the "Fair Market
       Value" as determined in good faith by the Board of Directors based upon
       such appraisals or valuation reports of such independent experts as the
       Board of Directors shall in good faith determine to be appropriate in
       accordance with good business practice.

    Any determination of Fair Market Value made under clauses 2 or 3 above shall
be described in a statement filed with the records of the actions of the Board
of Directors.

           (g) "Market Capitalization" of any series of Common stock on any date
       shall mean the product of (i) the Fair Market Value of one share of such
       series of Common Stock on such date and (ii) the number of shares of such
       series of Common Stock outstanding on such date.

           (h) "Market Value" as of any day of any security shall mean the
       average of the high and low reported sales prices regular way of a share
       of such class or series on such day (if such day is a Business Day, and,
       if such day is not a Business Day, on the Business Day immediately
       preceding such day); or, in case no such reported sale takes place on
       such Business Day, the average of the reported closing bid and asked
       prices regular way of a share of such class or series on such Business
       Day, in either case, on the New York Stock Exchange; or, if the shares of
       such class or series are not quoted on the New York Stock Exchange on
       such Business Day, on the Nasdaq National Market; or, if the shares of
       such class or series are not quoted on the Nasdaq National Market on such
       Business Day, the average of the closing bid and asked prices of a share
       of such class or series in the over-the-counter market on such Business
       Day as furnished by any New York Stock Exchange member firm selected from
       time to time by the corporation; or, if such closing bid and asked prices
       are not made available by any such New York Stock Exchange member firm on
       such Business Day (including, without limitation, because such securities
       are not publicly held), the market value as determined by an independent
       investment banking firm experienced in the valuation of securities
       selected in good faith by the Board of Directors. Any determination of
       Fair Market Value made under the final clause of the preceding sentence
       shall be described in a statement filed with the records of the actions
       of the Board of Directors.

           (i) "Qualified Tax Counsel" shall mean tax counsel who may be regular
       outside counsel to the Corporation but shall not be an officer or
       employee of the Corporation or any of its affiliates.

           (j) "Redemption Date" shall mean, in respect of any redemption of any
       share of a series of Common Stock effected pursuant to these Articles of
       Organization, the date upon which such redemption becomes effective.

           (k) "Related Business Transaction" shall mean, with respect to the
       Disposition of all or substantially all the properties and assets
       attributed to a particular series of Common Stock, such Disposition in a
       transaction or series of related transactions that result in the
       Corporation receiving in consideration of such properties and assets
       primarily equity securities (including, without limitation, capital
       stock, debt securities convertible into or exchangeable for equity
       securities or interests in a general or limited partnership or limited
       liability company, without regard to the voting power or other management
       or governance rights associated therewith) of any entity which
       (i) acquires such properties or assets or succeeds (by merger, formation
       of a joint venture or otherwise) to the business conducted with such
       properties or assets or controls such acquiror or successor and (ii) is
       engaged primarily or proposes to engage primarily in one or more
       businesses similar or complementary to the businesses conducted by the
       division or group of the Corporation to which were attributed such
       properties and assets prior to such Disposition, as determined by the
       Board of Directors.

                                      A-34
<PAGE>
           (l) "Tax Event" shall mean, with respect to any series of Common
       Stock that it has become (or will become, as the context may require)
       more likely than not that for United States Federal income tax purposes
       (i) the Corporation or the holders of its stock are, or at any time in
       the future will be, subject to tax or other adverse tax consequences upon
       the issuance or receipt of shares of such series of Common Stock or by
       reason of the existence of such series of Common Stock or (ii) either
       such series of Common Stock or the GGD Stock is not, or at any time in
       the future will not be, treated solely as stock of the Corporation.

           (m) "Tax Law Change" shall mean (i) any enactment of, amendment to,
       or change in the laws of the United States or any political subdivision
       thereof (including any announced proposed change by an applicable
       legislative committee or the chair in such laws), (ii) any promulgation
       of, amendment to, or change in the regulations under the laws of the
       United States or any political subdivision or taxing authority thereof or
       therein (including any announced proposed change in or promulgation of
       regulations by an administrative agency) or (iii) any official or
       administrative pronouncement or action or judicial decision interpreting
       or applying such laws or regulations. For purposes of rendering an
       opinion as to a Tax Law Change, tax counsel shall assume that any
       legislative or administrative proposals will be adopted or enacted as
       proposed.

    8.  DETERMINATIONS BY THE BOARD OF DIRECTORS.  Any determinations with
respect to any Division or the rights of holders of any series of Common Stock
made by the Board of Directors of the Corporation in good faith pursuant to or
in furtherance of any provision of these Articles of Organization relating to
the Common Stock shall be final and binding on all stockholders of the
Corporation.

H. DESCRIPTION OF THE PREFERRED STOCK

    1.  UNDESIGNATED PREFERRED STOCK.  Shares of Preferred Stock may be issued
from time to time in one or more series. The Board of Directors may determine,
in whole or in part, the preferences, voting powers, qualifications and special
or relative rights or privileges of any such series before the issuance of any
shares of that series. The Board of Directors shall determine the number of
shares constituting each series of Preferred Stock and each series shall have a
distinguishing designation.

    2.  TERMS OF THE SERIES A, SERIES B, SERIES C AND SERIES D JUNIOR
PARTICIPATING PREFERRED STOCK.

        (a)  AUTHORIZED AMOUNTS AND DESIGNATIONS.  Two million shares of
    Preferred Stock of the Corporation are designated as Series A Junior
    Participating Preferred Stock (the "Series A Preferred Stock"), 400,000
    shares of Preferred Stock are designated as Series B Junior Participating
    Preferred Stock (the "Series B Preferred Stock"), 400,000 shares of
    Preferred Stock are designated as Series C Junior Participating Preferred
    Stock (the "Series C Preferred Stock,") and 400,000 shares of Preferred
    Stock are designated as Series D Junior Preferred Stock (the "Series D
    Preferred Stock" and, together with the Series A Preferred Stock, the
    Series B Preferred Stock, the Series C Preferred Stock and any other series
    of Preferred Stock so designated by the Corporation's Board of Directors,
    the "Junior Preferred Stock"). To the extent legally permitted, such numbers
    of shares may be increased or decreased by vote of the Board of Directors,
    provided that no decrease shall reduce the number of shares of Junior
    Preferred Stock of any series to a number less than the number of shares of
    such series then outstanding plus the number of shares of such series
    reserved for issuance upon the exercise of outstanding options, rights or
    warrants or upon the conversion of any outstanding securities issued by the
    Corporation convertible into such series of Junior Preferred Stock.

        (b)  SERIES A PREFERRED STOCK.  A description of the Series A Preferred
    Stock and a statement of its preferences, voting powers, qualifications and
    special or relative rights or privileges is as follows:

           (1)  DIVIDENDS AND DISTRIBUTIONS.

               (A) Subject to the prior and superior rights of the holders of
           any shares of any series of Preferred Stock ranking prior and
           superior to the Series A Preferred Stock with respect to

                                      A-35
<PAGE>
           dividends, the holders of shares of Series A Preferred Stock, in
           preference to the holders of all shares of common stock of the
           Corporation (the "Common Shares"), and of any other junior stock,
           shall be entitled to receive, when, as and if declared by the Board
           of Directors out of funds legally available for the purpose,
           quarterly dividends payable in cash on the first day of March, June,
           September and December in each year (each such date being referred to
           herein as a "Quarterly Dividend Payment Date"), commencing on the
           first Quarterly Dividend Payment Date after the first issuance of a
           share or fraction of a share of Series A Preferred Stock, in an
           amount per share (rounded to the nearest cent) equal to the greater
           of (a) $1.00 or (b) subject to the provision for adjustment
           hereinafter set forth, 100 times the aggregate per share amount of
           all cash dividends, and 100 times the aggregate per share amount
           (payable in kind) of all non-cash dividends or other distributions,
           other than a dividend on shares of Genzyme General Division Common
           Stock (the "GGD Stock") payable in shares of GGD Stock or a
           subdivision of the outstanding shares of GGD Stock (by
           reclassification or otherwise), declared on the GGD Stock since the
           immediately preceding Quarterly Dividend Payment Date or, with
           respect to the first Quarterly Dividend Payment Date, since the first
           issuance of any share or fraction of a share of Series A Preferred
           Stock. In the event the Corporation shall at any time after June 12,
           1997 declare or pay any dividend on shares of GGD Stock payable in
           shares of GGD Stock, or effect a subdivision or combination or
           consolidation of the outstanding shares of GGD Stock (by
           reclassification or otherwise than by payment of a dividend in shares
           of GGD Stock) into a greater or lesser number of shares of GGD Stock,
           then in each such case the amount to which holders of shares of
           Series A Preferred Stock were entitled immediately prior to such
           event under clause (b) of the preceding sentence shall be adjusted by
           multiplying such amount by a fraction, the numerator of which is the
           number of shares of GGD Stock outstanding immediately after such
           event and the denominator of which is the number of shares of GGD
           Stock that were outstanding immediately prior to such event.

               (B) The Corporation shall declare a dividend or distribution on
           the Series A Preferred Stock as provided in Section IV.H.2(b)(1)(A)
           immediately after it declares a dividend or distribution on any
           shares of GGD Stock (other than a dividend payable in shares of GGD
           Stock), provided that, in the event no dividend or distribution shall
           have been declared on the GGD Stock during the period between any
           Quarterly Dividend Payment Date and the next subsequent Quarterly
           Dividend Payment Date, a dividend of $1.00 per share on the Series A
           Preferred Stock shall nevertheless be payable on such subsequent
           Quarterly Dividend Payment Date.

               (C) Dividends shall begin to accrue and be cumulative on
           outstanding shares of Series A Preferred Stock from the Quarterly
           Dividend Payment Date next preceding the date of issue of such
           shares, unless the date of issue of such shares is prior to the
           record date for the first Quarterly Dividend Payment Date, in which
           case dividends on such shares shall begin to accrue from the date of
           issue of such shares, or unless the date of issue is a Quarterly
           Dividend Payment Date or is a date after the record date for the
           determination of holders of shares of Series A Preferred Stock
           entitled to receive a quarterly dividend and before such Quarterly
           Dividend Payment Date, in either of which events such dividends shall
           begin to accrue and be cumulative from such Quarterly Dividend
           Payment Date. Accrued but unpaid dividends shall not bear interest.
           Dividends paid on the shares of Series A Preferred Stock in an amount
           less than the total amount of such dividends at the time accrued and
           payable on such shares shall be allocated pro rata on a
           share-by-share basis among all such shares at the time outstanding.
           The Board of Directors may fix a record date for the determination of
           holders of shares of Series A Preferred Stock entitled to receive
           payment of a dividend or distribution declared thereon, which record
           date shall be not more than 60 days prior to the date fixed for the
           payment thereof.

                                      A-36
<PAGE>
           (2)  VOTING RIGHTS.  The holders of shares of Series A Preferred
       Stock shall have the following voting rights:

               (A) Subject to the provision for adjustment hereinafter set
           forth, each share of Series A Preferred Stock shall entitle the
           holder thereof to 100 votes on all matters submitted to a vote of the
           stockholders of the Corporation. In the event the Corporation shall
           at any time after June 12, 1997 declare or pay any dividend on any
           shares of GGD Stock payable in shares of GGD Stock, or effect a
           subdivision or combination or consolidation of the outstanding shares
           of GGD Stock (by reclassification or otherwise than by payment of a
           dividend in shares of GGD Stock) into a greater or lesser number of
           shares of GGD Stock, then in each such case the number of votes per
           share to which holders of shares of Series A Preferred Stock were
           entitled immediately prior to such event shall be adjusted by
           multiplying such number by a fraction, the numerator of which is the
           number of shares of GGD Stock outstanding immediately after such
           event and the denominator of which is the number of shares of GGD
           Stock that were outstanding immediately prior to such event.

               (B) Except as otherwise provided herein, in the Articles of
           Organization, in any other vote of the Board of Directors of the
           Corporation creating a series of Preferred Stock, or by law, the
           holders of shares of Series A Preferred Stock and the holders of
           Common Shares and any other capital stock of the Corporation having
           general voting rights shall vote together as one series on all
           matters submitted to a vote of stockholders of the Corporation.

               (C) Except as set forth herein or as otherwise provided by law,
           holders of Series A Preferred Stock shall have no voting rights.

           (3)  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any liquidation,
       dissolution or winding up of the Corporation, no distribution shall be
       made (1) to the holders of shares of stock ranking junior (either as to
       dividends or upon liquidation, dissolution or winding up) to the
       Series A Preferred Stock unless, prior thereto, the holders of shares of
       Series A Preferred Stock shall have received $100 per share, plus an
       amount equal to accrued and unpaid dividends and distributions thereon,
       whether or not declared, to the date of such payment, provided that the
       holders of shares of Series A Preferred Stock shall be entitled to
       receive an aggregate amount per share, subject to the provision for
       adjustment hereinafter set forth, equal to 100 times the aggregate amount
       to be distributed per share to holders of shares of GGD Stock, or (2) to
       the holders of shares of stock ranking on a parity (either as to
       dividends or upon liquidation, dissolution or winding up) with the
       Series A Preferred Stock, except distributions made ratably on the
       Series A Preferred Stock and all other such parity stock in proportion to
       the total amounts to which the holders of all such shares are entitled
       upon such liquidation, dissolution or winding up. In the event the
       Corporation shall at any time after June 12, 1997 declare or pay any
       dividend on shares of GGD Stock payable in shares of GGD Stock, or effect
       a subdivision or combination or consolidation of the outstanding shares
       of GGD Stock (by reclassification or otherwise than by payment of a
       dividend in shares of GGD Stock) into a greater or lesser number of
       shares of GGD Stock, then in each such case the aggregate amount to which
       holders of shares of Series A Preferred Stock were entitled immediately
       prior to such event under the proviso in clause (1) of the preceding
       sentence shall be adjusted by multiplying such amount by a fraction, the
       numerator of which is the number of shares of GGD Stock outstanding
       immediately after such event and the denominator of which is the number
       of shares of GGD Stock that were outstanding immediately prior to such
       event.

           (4)  CONSOLIDATION, MERGER, ETC.  In case the Corporation shall enter
       into any consolidation, merger, combination or other transaction in which
       Common Shares are exchanged for or changed into other stock or
       securities, cash and or any other property, then in any such case each
       share of Series A Preferred Stock shall at the same time be similarly
       exchanged or changed into

                                      A-37
<PAGE>
       an amount per share (subject to the provision for adjustment hereinafter
       set forth) equal to 100 times the aggregate amount of stock, securities,
       cash and or any other property (payable in kind), as the case may be,
       into which or for which each share of GGD Stock is changed or exchanged.
       In the event the Corporation shall at any time after June 12, 1997
       declare or pay any dividend on any shares of GGD Stock payable in shares
       of GGD Stock, or effect a subdivision or combination or consolidation of
       the outstanding shares of GGD Stock (by reclassification or otherwise
       than by payment of a dividend in shares of GGD Stock) into a greater or
       lesser number of shares of GGD Stock, then in each such case the amount
       set forth in the preceding sentence with respect to the exchange or
       change of shares of Series A Preferred Stock shall be adjusted by
       multiplying such amount by a fraction, the numerator of which is the
       number of shares of GGD Stock outstanding immediately after such event
       and the denominator of which is the number of shares of GGD Stock that
       were outstanding immediately prior to such event.

        (c)  SERIES B PREFERRED STOCK.  A description of the Series B Preferred
    Stock and a statement of its preferences, voting powers, qualifications and
    special or relative rights or privileges is as follows:

           (1)  DIVIDENDS AND DISTRIBUTIONS.

               (A) Subject to the prior and superior rights of the holders of
           any shares of any series of Preferred Stock ranking prior and
           superior to the Series B Preferred Stock with respect to dividends,
           the holders of shares of Series B Preferred Stock, in preference to
           the holders of all Common Shares, and of any other junior stock,
           shall be entitled to receive, when, as and if declared by the Board
           of Directors out of funds legally available for the purpose,
           quarterly dividends payable in cash on the first day of March, June,
           September and December in each year (each such date being referred to
           herein as a "Quarterly Dividend Payment Date"), commencing on the
           first Quarterly Dividend Payment Date after the first issuance of a
           share or fraction of a share of Series B Preferred Stock, in an
           amount per share (rounded to the nearest cent) equal to the greater
           of (a) $1.00 or (b) subject to the provision for adjustment
           hereinafter set forth, 100 times the aggregate per share amount of
           all cash dividends, and 100 times the aggregate per share amount
           (payable in kind) of all non-cash dividends or other distributions,
           other than a dividend on shares of Genzyme Tissue Repair Division
           Common Stock (the "GTR Stock") payable in shares of GTR Stock or a
           subdivision of the outstanding shares of GTR Stock (by
           reclassification or otherwise), declared on the GTR Stock since the
           immediately preceding Quarterly Dividend Payment Date or, with
           respect to the first Quarterly Dividend Payment Date, since the first
           issuance of any share or fraction of a share of Series B Preferred
           Stock. In the event the Corporation shall at any time after June 12,
           1997 declare or pay any dividend on any shares of GTR Stock payable
           in shares of GTR Stock, or effect a subdivision or combination or
           consolidation of the outstanding shares of GTR Stock (by
           reclassification or otherwise than by payment of a dividend in shares
           of GTR Stock) into a greater or lesser number of shares of GTR Stock,
           then in each such case the amount to which holders of shares of
           Series B Preferred Stock were entitled immediately prior to such
           event under clause (b) of the preceding sentence shall be adjusted by
           multiplying such amount by a fraction, the numerator of which is the
           number of shares of GTR Stock outstanding immediately after such
           event and the denominator of which is the number of shares of GTR
           Stock that were outstanding immediately prior to such event.

               (B) The Corporation shall declare a dividend or distribution on
           the Series B Preferred Stock as provided in Section IV.H.2(c)(1)(A)
           immediately after it declares a dividend or distribution on any
           shares of GTR Stock (other than a dividend payable in shares of GTR
           Stock), provided that, in the event no dividend or distribution shall
           have been declared on the GTR Stock during the period between any
           Quarterly Dividend Payment Date and the next subsequent Quarterly
           Dividend Payment Date, a dividend of $1.00 per share on the

                                      A-38
<PAGE>
           Series B Preferred Stock shall nevertheless be payable on such
           subsequent Quarterly Dividend Payment Date.

               (C) Dividends shall begin to accrue and be cumulative on
           outstanding shares of Series B Preferred Stock from the Quarterly
           Dividend Payment Date next preceding the date of issue of such
           shares, unless the date of issue of such shares is prior to the
           record date for the first Quarterly Dividend Payment Date, in which
           case dividends on such shares shall begin to accrue from the date of
           issue of such shares, or unless the date of issue is a Quarterly
           Dividend Payment Date or is a date after the record date for the
           determination of holders of shares of Series B Preferred Stock
           entitled to receive a quarterly dividend and before such Quarterly
           Dividend Payment Date, in either of which events such dividends shall
           begin to accrue and be cumulative from such Quarterly Dividend
           Payment Date. Accrued but unpaid dividends shall not bear interest.
           Dividends paid on the shares of Series B Preferred Stock in an amount
           less than the total amount of such dividends at the time accrued and
           payable on such shares shall be allocated pro rata on a
           share-by-share basis among all such shares at the time outstanding.
           The Board of Directors may fix a record date for the determination of
           holders of shares of Series B Preferred Stock entitled to receive
           payment of a dividend or distribution declared thereon, which record
           date shall be not more than 60 days prior to the date fixed for the
           payment thereof.

           (2)  VOTING RIGHTS.  The holders of shares of Series B Preferred
       Stock shall have the following voting rights:

               (A) Subject to the provision for adjustment hereinafter set
           forth, each share of Series B Preferred Stock shall entitle the
           holder thereof to 100 times the number of votes to which the holder
           of each outstanding share of GTR Stock is then entitled on all
           matters submitted to a vote of the stockholders of the Corporation.
           In the event the Corporation shall at any time after June 12, 1997
           declare or pay any dividend on shares of GTR Stock payable in shares
           of GTR Stock, or effect a subdivision or combination or consolidation
           of the outstanding shares of GTR Stock (by reclassification or
           otherwise than by payment of a dividend in shares of GTR Stock) into
           a greater or lesser number of shares of GTR Stock, then in each such
           case the number of votes per share to which holders of shares of
           Series B Preferred Stock were entitled immediately prior to such
           event shall be adjusted by multiplying such number by a fraction, the
           numerator of which is the number of shares of GTR Stock outstanding
           immediately after such event and the denominator of which is the
           number of shares of GTR Stock that were outstanding immediately prior
           to such event.

               (B) Except as otherwise provided herein, in the Articles of
           Organization, in any other vote of the Board of Directors of the
           Corporation creating a series of Preferred Stock, or by law, the
           holders of shares of Series B Preferred Stock and the holders of
           Common Shares and any other capital stock of the Corporation having
           general voting rights shall vote together as one series on all
           matters submitted to a vote of stockholders of the Corporation.

               (C) Except as set forth herein or as otherwise provided by law,
           holders of Series B Preferred Stock shall have no voting rights.

           (3)  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any liquidation,
       dissolution or winding up of the Corporation, no distribution shall be
       made (1) to the holders of shares of stock ranking junior (either as to
       dividends or upon liquidation, dissolution or winding up) to the
       Series B Preferred Stock unless, prior thereto, the holders of shares of
       Series B Preferred Stock shall have received $100 per share, plus an
       amount equal to accrued and unpaid dividends and distributions thereon,
       whether or not declared, to the date of such payment, provided that the
       holders of shares of Series B Preferred Stock shall be entitled to
       receive an aggregate amount per share, subject to the provision for
       adjustment hereinafter set forth, equal to 100 times the aggregate

                                      A-39
<PAGE>
       amount to be distributed per share to holders of shares of GTR Stock, or
       (2) to the holders of shares of stock ranking on a parity (either as to
       dividends or upon liquidation, dissolution or winding up) with the
       Series B Preferred Stock, except distributions made ratably on the
       Series B Preferred Stock and all other such parity stock in proportion to
       the total amounts to which the holders of all such shares are entitled
       upon such liquidation, dissolution or winding up. In the event the
       Corporation shall at any time after June 12, 1997 declare or pay any
       dividend on any shares of GTR Stock payable in shares of GTR Stock, or
       effect a subdivision or combination or consolidation of the outstanding
       shares of GTR Stock (by reclassification or otherwise than by payment of
       a dividend in shares of GTR Stock) into a greater or lesser number of
       shares of GTR Stock, then in each such case the aggregate amount to which
       holders of shares of Series B Preferred Stock were entitled immediately
       prior to such event under the proviso in clause (1) of the preceding
       sentence shall be adjusted by multiplying such amount by a fraction, the
       numerator of which is the number of shares of GTR Stock outstanding
       immediately after such event and the denominator of which is the number
       of shares of GTR Stock that were outstanding immediately prior to such
       event.

           (4)  CONSOLIDATION, MERGER, ETC.  In case the Corporation shall enter
       into any consolidation, merger, combination or other transaction in which
       Common Shares are exchanged for or changed into other stock or
       securities, cash and or any other property, then in any such case each
       share of Series B Preferred Stock shall at the same time be similarly
       exchanged or changed into an amount per share (subject to the provision
       for adjustment hereinafter set forth) equal to 100 times the aggregate
       amount of stock, securities, cash and or any other property (payable in
       kind), as the case may be, into which or for which each share of GTR
       Stock is changed or exchanged. In the event the Corporation shall at any
       time after June 12, 1997 declare or pay any dividend on any shares of GTR
       Stock payable in shares of GTR Stock, or effect a subdivision or
       combination or consolidation of the outstanding shares of GTR Stock (by
       reclassification or otherwise than by payment of a dividend in shares of
       GTR Stock) into a greater or lesser number of shares of GTR Stock, then
       in each such case the amount set forth in the preceding sentence with
       respect to the exchange or change of shares of Series B Preferred Stock
       shall be adjusted by multiplying such amount by a fraction, the numerator
       of which is the number of shares of GTR Stock outstanding immediately
       after such event and the denominator of which is the number of shares of
       GTR Stock that were outstanding immediately prior to such event.

        (d)  SERIES C PREFERRED STOCK.  A description of the Series C Preferred
    Stock and a statement of its preferences, voting powers, qualifications and
    special or relative rights or privileges is as follows:

           (1)  DIVIDENDS AND DISTRIBUTIONS.

               (A) Subject to the prior and superior rights of the holders of
           any shares of any series of Preferred Stock ranking prior and
           superior to the Series C Preferred Stock with respect to dividends,
           the holders of shares of Series C Preferred Stock, in preference to
           the holders of Common Shares, and of any other junior stock, shall be
           entitled to receive, when, as and if declared by the Board of
           Directors out of funds legally available for the purpose, quarterly
           dividends payable in cash on the first day of March, June, September
           and December in each year (each such date being referred to herein as
           a "Quarterly Dividend Payment Date"), commencing on the first
           Quarterly Dividend Payment Date after the first issuance of a share
           or fraction of a share of Series C Preferred Stock, in an amount per
           share (rounded to the nearest cent) equal to the greater of
           (a) $1.00 or (b) subject to the provision for adjustment hereinafter
           set forth, 100 times the aggregate per share amount of all cash
           dividends, and 100 times the aggregate per share amount (payable in
           kind) of all non-cash dividends or other distributions, other than a
           dividend on shares of Genzyme Molecular Oncology Division Common
           Stock (the "GMO Stock") payable in shares of GMO Stock or a
           subdivision of the outstanding shares of GMO Stock (by
           reclassification or otherwise), declared on the GMO

                                      A-40
<PAGE>
           Stock since the immediately preceding Quarterly Dividend Payment Date
           or, with respect to the first Quarterly Dividend Payment Date, since
           the first issuance of any share or fraction of a share of Series C
           Preferred Stock. In the event the Corporation shall at any time after
           June 12, 1997 declare or pay any dividend on any shares of GMO Stock
           payable in shares of GMO Stock, or effect a subdivision or
           combination or consolidation of the outstanding shares of GMO Stock
           (by reclassification or otherwise than by payment of a dividend in
           shares of GMO Stock) into a greater or lesser number of shares of GMO
           Stock, then in each such case the amount to which holders of shares
           of Series C Preferred Stock were entitled immediately prior to such
           event under clause (b) of the preceding sentence shall be adjusted by
           multiplying such amount by a fraction, the numerator of which is the
           number of shares of GMO Stock outstanding immediately after such
           event and the denominator of which is the number of shares of GMO
           Stock that were outstanding immediately prior to such event.

               (B) The Corporation shall declare a dividend or distribution on
           the Series C Preferred Stock as provided in Section IV.H.2(d)(1)(A)
           immediately after it declares a dividend or distribution on any
           shares of GMO Stock (other than a dividend payable in shares of GMO
           Stock), provided that, in the event no dividend or distribution shall
           have been declared on the GMO Stock during the period between any
           Quarterly Dividend Payment Date and the next subsequent Quarterly
           Dividend Payment Date, a dividend of $1.00 per share on the Series C
           Preferred Stock shall nevertheless be payable on such subsequent
           Quarterly Dividend Payment Date.

               (C) Dividends shall begin to accrue and be cumulative on
           outstanding shares of Series C Preferred Stock from the Quarterly
           Dividend Payment Date next preceding the date of issue of such
           shares, unless the date of issue of such shares is prior to the
           record date for the first Quarterly Dividend Payment Date, in which
           case dividends on such shares shall begin to accrue from the date of
           issue of such shares, or unless the date of issue is a Quarterly
           Dividend Payment Date or is a date after the record date for the
           determination of holders of shares of Series C Preferred Stock
           entitled to receive a quarterly dividend and before such Quarterly
           Dividend Payment Date, in either of which events such dividends shall
           begin to accrue and be cumulative from such Quarterly Dividend
           Payment Date. Accrued but unpaid dividends shall not bear interest.
           Dividends paid on the shares of Series C Preferred Stock in an amount
           less than the total amount of such dividends at the time accrued and
           payable on such shares shall be allocated pro rata on a
           share-by-share basis among all such shares at the time outstanding.
           The Board of Directors may fix a record date for the determination of
           holders of shares of Series C Preferred Stock entitled to receive
           payment of a dividend or distribution declared thereon, which record
           date shall be not more than 60 days prior to the date fixed for the
           payment thereof.

           (2)  VOTING RIGHTS.  The holders of shares of Series C Preferred
       Stock shall have the following voting rights:

               (A) Subject to the provision for adjustment hereinafter set
           forth, each share of Series C Preferred Stock shall entitle the
           holder thereof to 100 times the number of votes to which the holder
           of each outstanding share of GMO Stock is then entitled on all
           matters submitted to a vote of the stockholders of the Corporation.
           In the event the Corporation shall at any time after June 12, 1997
           declare or pay any dividend on any shares of GMO Stock payable in
           shares of GMO Stock, or effect a subdivision or combination or
           consolidation of the outstanding shares of GMO Stock (by
           reclassification or otherwise than by payment of a dividend in shares
           of GMO Stock) into a greater or lesser number of shares of GMO Stock,
           then in each such case the number of votes per share to which holders
           of shares of Series C Preferred Stock were entitled immediately prior
           to such event shall be adjusted by multiplying such number by a
           fraction, the numerator of which is the number of shares of GMO

                                      A-41
<PAGE>
           Stock outstanding immediately after such event and the denominator of
           which is the number of shares of GMO Stock that were outstanding
           immediately prior to such event.

               (B) Except as otherwise provided herein, in the Articles of
           Organization, in any other vote of the Board of Directors of the
           Corporation creating a series of Preferred Stock, or by law, the
           holders of shares of Series C Preferred Stock and the holders of
           Common Shares and any other capital stock of the Corporation having
           general voting rights shall vote together as one series on all
           matters submitted to a vote of stockholders of the Corporation.

               (C) Except as set forth herein or as otherwise provided by law,
           holders of Series C Preferred Stock shall have no voting rights.

           (3)  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any liquidation,
       dissolution or winding up of the Corporation, no distribution shall be
       made (1) to the holders of shares of stock ranking junior (either as to
       dividends or upon liquidation, dissolution or winding up) to the
       Series C Preferred Stock unless, prior thereto, the holders of shares of
       Series C Preferred Stock shall have received $100 per share, plus an
       amount equal to accrued and unpaid dividends and distributions thereon,
       whether or not declared, to the date of such payment, provided that the
       holders of shares of Series C Preferred Stock shall be entitled to
       receive an aggregate amount per share, subject to the provision for
       adjustment hereinafter set forth, equal to 100 times the aggregate amount
       to be distributed per share to holders of shares of GMO Stock, or (2) to
       the holders of shares of stock ranking on a parity (either as to
       dividends or upon liquidation, dissolution or winding up) with the
       Series C Preferred Stock, except distributions made ratably on the
       Series C Preferred Stock and all other such parity stock in proportion to
       the total amounts to which the holders of all such shares are entitled
       upon such liquidation, dissolution or winding up. In the event the
       Corporation shall at any time after June 12, 1997 declare or pay any
       dividend on any shares of GMO Stock payable in shares of GMO Stock, or
       effect a subdivision or combination or consolidation of the outstanding
       shares of GMO Stock (by reclassification or otherwise than by payment of
       a dividend in shares of GMO Stock) into a greater or lesser number of
       shares of GMO Stock, then in each such case the aggregate amount to which
       holders of shares of Series C Preferred Stock were entitled immediately
       prior to such event under the proviso in clause (1) of the preceding
       sentence shall be adjusted by multiplying such amount by a fraction, the
       numerator of which is the number of shares of GMO Stock outstanding
       immediately after such event and the denominator of which is the number
       of shares of GMO Stock that were outstanding immediately prior to such
       event.

           (4)  CONSOLIDATION, MERGER, ETC.  In case the Corporation shall enter
       into any consolidation, merger, combination or other transaction in which
       Common Shares are exchanged for or changed into other stock or
       securities, cash and or any other property, then in any such case each
       share of Series C Preferred Stock shall at the same time be similarly
       exchanged or changed into an amount per share (subject to the provision
       for adjustment hereinafter set forth) equal to 100 times the aggregate
       amount of stock, securities, cash and or any other property (payable in
       kind), as the case may be, into which or for which each share of GMO
       Stock is changed or exchanged. In the event the Corporation shall at any
       time after June 12, 1997 declare or pay any dividend on shares of GMO
       Stock payable in shares of GMO Stock, or effect a subdivision or
       combination or consolidation of the outstanding shares of GMO Stock (by
       reclassification or otherwise than by payment of a dividend in shares of
       GMO Stock) into a greater or lesser number of shares of GMO Stock, then
       in each such case the amount set forth in the preceding sentence with
       respect to the exchange or change of shares of Series C Preferred Stock
       shall be adjusted by multiplying such amount by a fraction, the numerator
       of which is the number of shares of GMO Stock outstanding immediately
       after such event and the denominator of which is the number of shares of
       GMO Stock that were outstanding immediately prior to such event.

                                      A-42
<PAGE>
        (e)  SERIES D PREFERRED STOCK.  A description of the Series D Preferred
    Stock and a statement of its preferences, voting powers, qualifications and
    special or relative rights or privileges is as follows:

           (1)  DIVIDENDS AND DISTRIBUTIONS.

               (A) Subject to the prior and superior rights of the holders of
           any shares of any series of Preferred Stock ranking prior and
           superior to the Series D Preferred Stock with respect to dividends,
           the holders of shares of Series D Preferred Stock, in preference to
           the holders of Common Shares, and of any other junior stock, shall be
           entitled to receive, when, as and if declared by the Board of
           Directors out of funds legally available for the purpose, quarterly
           dividends payable in cash on the first day of March, June, September
           and December in each year (each such date being referred to herein as
           a "Quarterly Dividend Payment Date"), commencing on the first
           Quarterly Dividend Payment Date after the first issuance of a share
           or fraction of a share of Series D Preferred Stock, in an amount per
           share (rounded to the nearest cent) equal to the greater of
           (a) $1.00 or (b) subject to the provision for adjustment hereinafter
           set forth, 100 times the aggregate per share amount of all cash
           dividends, and 100 times the aggregate per share amount (payable in
           kind) of all non-cash dividends or other distributions, other than a
           dividend on shares of Genzyme Surgical Products Division Common Stock
           (the "GSP Stock") payable in shares of GSP Stock or a subdivision of
           the outstanding shares of GSP Stock (by reclassification or
           otherwise), declared on the GSP Stock since the immediately preceding
           Quarterly Dividend Payment Date or, with respect to the first
           Quarterly Dividend Payment Date, since the first issuance of any
           share or fraction of a share of Series D Preferred Stock. In the
           event the Corporation shall at any time after May 26, 1999 declare or
           pay any dividend on any shares of GSP Stock payable in shares of GSP
           Stock, or effect a subdivision or combination or consolidation of the
           outstanding shares of GSP Stock (by reclassification or otherwise
           than by payment of a dividend in shares of GSP Stock) into a greater
           or lesser number of shares of GSP Stock, then in each such case the
           amount to which holders of shares of Series D Preferred Stock were
           entitled immediately prior to such event under clause (b) of the
           preceding sentence shall be adjusted by multiplying such amount by a
           fraction, the numerator of which is the number of shares of GSP Stock
           outstanding immediately after such event and the denominator of which
           is the number of shares of GSP Stock that were outstanding
           immediately prior to such event.

               (B) The Corporation shall declare a dividend or distribution on
           the Series D Preferred Stock as provided in Section IV.H.2(e)(1)(A)
           immediately after it declares a dividend or distribution on any
           shares of GSP Stock (other than a dividend payable in shares of GSP
           Stock), provided that, in the event no dividend or distribution shall
           have been declared on the GSP Stock during the period between any
           Quarterly Dividend Payment Date and the next subsequent Quarterly
           Dividend Payment Date, a dividend of $1.00 per share on the Series D
           Preferred Stock shall nevertheless be payable on such subsequent
           Quarterly Dividend Payment Date.

               (C) Dividends shall begin to accrue and be cumulative on
           outstanding shares of Series D Preferred Stock from the Quarterly
           Dividend Payment Date next preceding the date of issue of such
           shares, unless the date of issue of such shares is prior to the
           record date for the first Quarterly Dividend Payment Date, in which
           case dividends on such shares shall begin to accrue from the date of
           issue of such shares, or unless the date of issue is a Quarterly
           Dividend Payment Date or is a date after the record date for the
           determination of holders of shares of Series D Preferred Stock
           entitled to receive a quarterly dividend and before such Quarterly
           Dividend Payment Date, in either of which events such dividends shall
           begin to accrue and be cumulative from such Quarterly Dividend
           Payment Date. Accrued but unpaid dividends shall not bear interest.
           Dividends paid on the shares of Series D Preferred Stock in an amount
           less than the total amount of such dividends at the time

                                      A-43
<PAGE>
           accrued and payable on such shares shall be allocated pro rata on a
           share-by-share basis among all such shares at the time outstanding.
           The Board of Directors may fix a record date for the determination of
           holders of shares of Series D Preferred Stock entitled to receive
           payment of a dividend or distribution declared thereon, which record
           date shall be not more than 60 days prior to the date fixed for the
           payment thereof.

           (2)  VOTING RIGHTS.  The holders of shares of Series D Preferred
       Stock shall have the following voting rights:

               (A) Subject to the provision for adjustment hereinafter set
           forth, each share of Series D Preferred Stock shall entitle the
           holder thereof to 100 times the number of votes to which the holder
           of each outstanding share of GSP Stock is then entitled on all
           matters submitted to a vote of the stockholders of the Corporation.
           In the event the Corporation shall at any time after May 26, 1999
           declare or pay any dividend on any shares of GSP Stock payable in
           shares of GSP Stock, or effect a subdivision or combination or
           consolidation of the outstanding shares of GSP Stock (by
           reclassification or otherwise than by payment of a dividend in shares
           of GSP Stock) into a greater or lesser number of shares of GSP Stock,
           then in each such case the number of votes per share to which holders
           of shares of Series D Preferred Stock were entitled immediately prior
           to such event shall be adjusted by multiplying such number by a
           fraction, the numerator of which is the number of shares of GSP Stock
           outstanding immediately after such event and the denominator of which
           is the number of shares of GSP Stock that were outstanding
           immediately prior to such event.

               (B) Except as otherwise provided herein, in the Articles of
           Organization, in any other vote of the Board of Directors of the
           Corporation creating a series of Preferred Stock, or by law, the
           holders of shares of Series D Preferred Stock and the holders of
           Common Shares and any other capital stock of the Corporation having
           general voting rights shall vote together as one series on all
           matters submitted to a vote of stockholders of the Corporation.

               (C) Except as set forth herein or as otherwise provided by law,
           holders of Series D Preferred Stock shall have no voting rights.

           (3)  LIQUIDATION, DISSOLUTION OR WINDING UP.  Upon any liquidation,
       dissolution or winding up of the Corporation, no distribution shall be
       made (1) to the holders of shares of stock ranking junior (either as to
       dividends or upon liquidation, dissolution or winding up) to the
       Series D Preferred Stock unless, prior thereto, the holders of shares of
       Series D Preferred Stock shall have received $100 per share, plus an
       amount equal to accrued and unpaid dividends and distributions thereon,
       whether or not declared, to the date of such payment, provided that the
       holders of shares of Series D Preferred Stock shall be entitled to
       receive an aggregate amount per share, subject to the provision for
       adjustment hereinafter set forth, equal to 100 times the aggregate amount
       to be distributed per share to holders of shares of GSP Stock, or (2) to
       the holders of shares of stock ranking on a parity (either as to
       dividends or upon liquidation, dissolution or winding up) with the
       Series D Preferred Stock, except distributions made ratably on the
       Series D Preferred Stock and all other such parity stock in proportion to
       the total amounts to which the holders of all such shares are entitled
       upon such liquidation, dissolution or winding up. In the event the
       Corporation shall at any time after May 26, 1999 declare or pay any
       dividend on any shares of GSP Stock payable in shares of GSP Stock, or
       effect a subdivision or combination or consolidation of the outstanding
       shares of GSP Stock (by reclassification or otherwise than by payment of
       a dividend in shares of GSP Stock) into a greater or lesser number of
       shares of GSP Stock, then in each such case the aggregate amount to which
       holders of shares of Series D Preferred Stock were entitled immediately
       prior to such event under the proviso in clause (1) of the preceding
       sentence shall be adjusted by multiplying such amount by a fraction, the
       numerator of which is the number of shares of GSP Stock outstanding
       immediately after such event and the

                                      A-44
<PAGE>
       denominator of which is the number of shares of GSP Stock that were
       outstanding immediately prior to such event.

           (4)  CONSOLIDATION, MERGER, ETC.  In case the Corporation shall enter
       into any consolidation, merger, combination or other transaction in which
       Common Shares are exchanged for or changed into other stock or
       securities, cash and or any other property, then in any such case each
       share of Series D Preferred Stock shall at the same time be similarly
       exchanged or changed into an amount per share (subject to the provision
       for adjustment hereinafter set forth) equal to 100 times the aggregate
       amount of stock, securities, cash and or any other property (payable in
       kind), as the case may be, into which or for which each share of GSP
       Stock is changed or exchanged. In the event the Corporation shall at any
       time after May 26, 1999 declare or pay any dividend on shares of GSP
       Stock payable in shares of GSP Stock, or effect a subdivision or
       combination or consolidation of the outstanding shares of GSP Stock (by
       reclassification or otherwise than by payment of a dividend in shares of
       GSP Stock) into a greater or lesser number of shares of GSP Stock, then
       in each such case the amount set forth in the preceding sentence with
       respect to the exchange or change of shares of Series D Preferred Stock
       shall be adjusted by multiplying such amount by a fraction, the numerator
       of which is the number of shares of GSP Stock outstanding immediately
       after such event and the denominator of which is the number of shares of
       GSP Stock that were outstanding immediately prior to such event.

        (f)  GENERAL PROVISIONS.  Except as otherwise specifically provided in a
    particular series of Junior Preferred Stock, the following provisions shall
    apply to all series of Junior Preferred Stock:

           (1)  CERTAIN RESTRICTIONS.

               (A) Whenever quarterly dividends or other dividends or
           distributions payable on the Junior Preferred Stock are in arrears,
           thereafter and until all accrued and unpaid dividends and
           distributions, whether or not declared, on shares of Junior Preferred
           Stock outstanding shall have been paid in full, the Corporation shall
           not:

                   (i) declare or pay dividends, or make any other
               distributions, on any shares of stock ranking junior (either as
               to dividends or upon liquidation, dissolution or winding up) to
               the Junior Preferred Stock;

                   (ii) declare or pay dividends, or make any other
               distributions, on any shares of stock ranking on a parity (either
               as to dividends or upon liquidation, dissolution or winding up)
               with the Junior Preferred Stock, except dividends paid ratably on
               the Junior Preferred Stock and all such parity stock on which
               dividends are payable or in arrears in proportion to the total
               amounts to which the holders of all such shares are then
               entitled;

                   (iii) redeem or purchase or otherwise acquire for
               consideration shares of any stock ranking junior (either as to
               dividends or upon liquidation, dissolution or winding up) to the
               Junior Preferred Stock, provided that the Corporation may at any
               time redeem, purchase or otherwise acquire shares of any such
               junior stock in exchange for shares of any stock of the
               Corporation ranking junior (either as to dividends or upon
               dissolution, liquidation or winding up) to the Junior Preferred
               Stock; or

                   (iv) redeem, purchase or otherwise acquire for consideration
               any shares of Junior Preferred Stock, or any shares of stock
               ranking on a parity with the Junior Preferred Stock, except in
               accordance with a purchase offer made in writing or by
               publication (as determined by the Board of Directors) to all
               holders of such shares upon such terms as the Board of Directors,
               after consideration of the respective annual dividend rates and
               other relative rights and preferences of the respective series
               and classes, shall determine in good faith will result in fair
               and equitable treatment among the respective series or classes.

                                      A-45
<PAGE>
        (2) The Corporation shall not permit any subsidiary of the Corporation
    to purchase or otherwise acquire for consideration any shares of stock of
    the Corporation unless the Corporation could, under Section IV.G.2(f)(1)(A)
    purchase or otherwise acquire such shares at such time and in such manner.

        (g)  REACQUIRED SHARES.  Any shares of Junior Preferred Stock purchased
    or otherwise acquired by the Corporation in any manner whatsoever shall be
    retired and cancelled promptly after the acquisition thereof. All such
    shares shall upon their cancellation become authorized but unissued shares
    of Preferred Stock and may be reissued as shares of the same series of
    Preferred Stock or as part of a new series of Preferred Stock, subject to
    the conditions and restrictions on issuance set forth herein, in the
    Articles of Organization, in any other vote of the Board of Directors of the
    Corporation creating a series of Preferred Stock, or as otherwise required
    by law.

        (h)  REDEMPTION.  The shares of Junior Preferred Stock shall not be
    redeemable.

        (i)  RANK.  The Series A Preferred Stock, the Series B Preferred Stock,
    the Series C Preferred Stock and the Series D Preferred Stock shall rank
    equally with respect to the payment of dividends and the distribution of
    assets together with any other series of the Corporation's Preferred Stock
    that specifically provide that they shall rank equally with Junior Preferred
    Stock. The Junior Preferred Stock shall rank junior with respect to the
    payment of dividends and the distribution of assets to all series of the
    Corporation's Preferred Stock that specifically provide that they shall rank
    prior to the Junior Preferred Stock. Nothing herein shall preclude the Board
    from creating any series of Preferred Stock ranking on a parity with or
    prior to the Junior Preferred Stock as to the payment of dividends or the
    distribution of assets.

        (j)  AMENDMENT.  The Articles of Organization of the Corporation shall
    not be amended in any manner which would materially alter or change the
    powers, preferences or special rights of the holders of Junior Preferred
    Stock so as to affect them adversely without the affirmative vote of the
    holders of at least two-thirds of each outstanding series of Junior
    Preferred Stock, voting together as a single series, provided that, any two
    or more series of Junior Preferred Stock that are adversely affected in the
    same manner shall vote together as a single class.

        (k)  FRACTIONAL SHARES.  The Junior Preferred Stock may be issued in
    fractions of a share which shall entitle the holder, in proportion to such
    holder's fractional shares, to exercise voting rights, receive dividends,
    participate in distributions and to have the benefit of all other rights of
    holders of the Junior Preferred Stock.

                                      A-46
<PAGE>
                                   APPENDIX B
                          MASSACHUSETTS APPRAISAL LAW

CHAPTER 156B OF THE GENERAL LAWS OF MASSACHUSETTS

SECTION 86. SECTIONS APPLICABLE TO APPRAISAL; PREREQUISITES

    If a corporation proposes to take a corporate action as to which any section
of this chapter provides that a stockholder who objects to such action shall
have the right to demand payment for his shares and an appraisal thereof,
sections eighty-seven to ninety-eight, inclusive, shall apply except as
otherwise specifically provided in any section of this chapter. Except as
provided in sections eighty-two and eight-three, no stockholder shall have such
right unless (1) he files with the corporation before the taking of the vote of
the shareholders on such corporate action, written objection to the proposed
action stating that he intends to demand payment for his shares if the action is
taken and (2) his shares are not voted in favor of the proposed action.

SECTION 87. STATEMENT OF RIGHTS OF OBJECTING STOCKHOLDERS IN NOTICE OF MEETING;
            FORM

    The notice of the meeting of stockholders at which the approval of such
proposed action is to be considered shall contain a statement of the rights of
objecting stockholders. The giving of such notice shall not be deemed to create
any rights in any stockholder receiving the same to demand payment for his
stock, and the directors may authorize the inclusion in any such notice of a
statement of opinion by the management as to the existence or non-existence of
the right of the stockholders to demand payment for their stock on account of
the proposed corporate action. The notice may be in such form as the directors
or officers calling the meeting deem advisable, but the following form of notice
shall be sufficient to comply with this section:

    "If the action proposed is approved by the stockholders at the meeting and
effected by the corporation, any stockholder (1) who files with the corporation
before the taking of the vote on the approval of such action, written objection
to the proposed action stating the he intends to demand payment for his shares
if the action is taken and (2) whose shares are not voted in favor of such
action has or may have the right to demand in writing from the corporation (OR,
IN THE CASE OF A CONSOLIDATION OR MERGER, THE NAME OF THE RESULTING OR SURVIVING
CORPORATION SHALL BE INSERTED), within twenty days after the date of mailing to
him of notice in writing that the corporate action has become effective,
payments for his shares and an appraisal of the value thereof. Such corporation
and any such stockholder shall in such cases have the rights and duties and
shall follow the procedure set forth in sections 88 to 98, inclusive, of chapter
156B of the General Laws of Massachusetts."

SECTION 88. NOTICE OF EFFECTIVENESS OF ACTION OBJECTED TO

    The corporation taking such action, or in the case of a merger or
consolidation the surviving or resulting corporation, shall, within ten days
after the date on which such corporate action became effective, notify each
stockholder who filed a written objection meeting the requirements of section
eighty-six and whose shares were not voted in favor of the approval of such
action, that the action approved at the meeting of the corporation of which he
is a stockholder has become effective. The giving of such notice shall not be
deemed to create any rights in any stockholder receiving the same to demand
payment for his stock. The notice shall be sent by registered or certified mail,
addressed to the stockholder at his last known address as it appears in the
records of the corporation.

                                      B-1
<PAGE>
SECTION 89. DEMAND FOR PAYMENT; TIME FOR PAYMENT

    If within twenty days after the date of mailing of a notice under subsection
(e) of section eight-two, subsection (f) of section eighty-three, or section
eighty-eight, any stockholder to whom the corporation was required to give such
notice shall demand in writing from the corporation taking such action, or in
the case of a consolidation or merger from the resulting or surviving
corporation, payment for his stock, the corporation upon which such demand is
made shall pay to him the fair value of his stock within thirty days after the
expiration of the period during which such demand may be made.

SECTION 90. DEMAND FOR DETERMINATION OF VALUE; BILL IN EQUITY; VENUE

    If during the period of thirty days provided for in section eighty-nine the
corporation upon which such demand is made and any such objecting stockholder
fail to agree as to the value of such stock, such corporation or any such
stockholder may within four months after the expiration of such thirty-day
period demand a determination of the value of the stock of all such objecting
stockholders by a bill in equity filed in the superior court in the county where
the corporation in which such objecting stockholder held stock had or has its
principal office in the commonwealth.

SECTION 91. PARTIES TO SUIT TO DETERMINE VALUE; SERVICE

    If the bill is filed by the corporation, it shall name as parties respondent
all stockholders who have demanded payment for their shares and with whom the
corporation has not reached agreement as to the value thereof. If the bill is
filed by a stockholder, he shall bring the bill in his own behalf and in behalf
of all other stockholders who have demanded payment for their shares and with
whom the corporation has not reached agreement as to the value thereof, and
service of the bill shall be made upon the corporation by subpoena with a copy
of the bill annexed. The corporation shall file with its answer a duly verified
list of all such other stockholders, and such stockholders shall thereupon be
deemed to have been added as parties to the bill. The corporation shall give
notice in such form and returnable on such date as the court shall order to each
stockholder party to the bill by registered or certified mail, addressed to the
last known address of such stockholder as shown in the records of the
corporation, and the court may order such additional notice by publication or
otherwise as it deems advisable. Each stockholder who makes demand as provided
in section eighty-nine shall be deemed to have consented to the provisions of
this section relating to notice, and the giving of notice by the corporation to
any such stockholder in compliance with the order of the court shall be a
sufficient service of process on him. Failure to give notice to any stockholder
making demand shall not invalidate the proceedings as to other stockholders to
whom notice was properly given, and the court may at any time before the entry
of a final decree make supplementary orders of notice.

SECTION 92. DECREE DETERMINING VALUE AND ORDERING PAYMENT; VALUATION DATE

    After hearing the court shall enter a decree determining the fair value of
the stock of those stockholders who have become entitled to the valuation of and
payment for their shares, and shall order the corporation to make payment of
such value, together with interest, if any, as hereinafter provided, to the
stockholders entitled thereto upon the transfer by them to the corporation of
the certificates representing such stock if certificated or, if uncertificated,
upon receipt of an instruction transferring such stock to the corporation. For
this purpose, the value of the shares shall be determined as of the day
preceding the date of the vote approving the proposed corporate action and shall
be exclusive of any element of value arising from the expectation or
accomplishment of the proposed corporate action.

                                      B-2
<PAGE>
SECTION 93. REFERENCE TO SPECIAL MASTER

    The court in its discretion may refer the bill or any question arising
thereunder to a special master to hear the parties, make findings and report the
same to the court, all in accordance with the usual practice in suits in equity
in the superior court.

SECTION 94. NOTATION ON STOCK CERTIFICATES OF PENDENCY OF BILL

    On motion the court may order stockholder parties to the bill to submit
their certificates of stock to the corporation for the notation thereon of the
pendency of the bill and may order the corporation to note such pendency in its
records with respect to any uncertificated shares held by such stockholders
parties, and may on motion dismiss the bill as to any stockholder who fails to
comply with such order.

SECTION 95. COSTS; INTEREST

    The costs of the bill, including the reasonable compensation and expenses of
any master appointed by the court, but exclusive of fees of counsel or of
experts retained by any party, shall be determined by the court and taxed upon
the parties to the bill, or any of them, in such manner as appears to be
equitable, except that all costs of giving notice to stockholders as provided in
this chapter shall be paid by the corporation. Interest shall be paid upon any
award from the date of the vote approving the proposed corporate action, and the
court may on application of any interested party determine the amount of
interest to be paid in the case of any stockholder.

SECTION 96. DIVIDENDS AND VOTING RIGHTS AFTER DEMAND FOR PAYMENT

    Any stockholder who has demanded payment for his stock as provided in this
chapter shall not thereafter be entitled to notice of any meeting of
stockholders or to vote such stock for any purpose and shall not be entitled to
the payment of dividends or other distribution on the stock (except dividends or
other distributions payable to stockholders of record at a date which is prior
to the date of the vote approving the proposed corporate action) unless:

    (1) bill shall not be filed within the time provided in section ninety;

    (2) A bill, if filed, shall be dismissed as to such stockholder; or

    (3) Such stockholder shall with the written approval of the corporation, or
       in the case of a consolidation or merger, the resulting or surviving
       corporation, deliver to it a written withdrawal of his objections to and
       an acceptance of such corporate action.

    Notwithstanding the provisions of clauses (1) to (3), inclusive, said
stockholder shall have only the rights of a stockholder who did not so demand
payment for his stock as provided in this chapter.

SECTION 97. STATUS OF SHARES PAID FOR

    The shares of the corporation paid for by the corporation pursuant to the
provisions of this chapter shall have the status of treasury stock, or in the
case of a consolidation or merger the shares or the securities of the resulting
or surviving corporation into which the shares of such objecting stockholder
would have been converted had he not objected to such consolidation or merger
shall have the status of treasury stock or securities.

SECTION 98. EXCLUSIVE REMEDY; EXCEPTION

    The enforcement by a stockholder of his right to receive payment for his
shares in the manner provided in this chapter shall be an exclusive remedy
except that this chapter shall not exclude the right of such stockholder to
bring or maintain an appropriate proceeding to obtain relief on the ground that
such corporate action will be or is illegal or fraudulent as to him.

                                      B-3
<PAGE>
          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                     GENZYME GENERAL DIVISION COMMON STOCK

    By signing this proxy, I appoint Henri A. Termeer, Michael S. Wyzga and
Peter Wirth, and each of them acting singly, my attorney and proxy, with full
power of substitution, to vote on my behalf all of the shares of Genzyme General
Division common stock that I am entitled to vote at the Annual Meeting of
Stockholders to be held on May 25, 2000, and at any adjournments of the meeting.
This proxy revokes any earlier proxy I have signed with respect to these shares.

    If properly executed, this proxy will be voted in the manner you specify. If
no specification is made, your shares of Genzyme General stock will be voted FOR
each of the proposals. The proxies are authorized to vote your shares, in their
discretion, on any other matter that is properly brought before the meeting.

                     PLEASE SIGN AND MAIL YOUR PROXY TODAY.

<TABLE>
<S>  <C>                                                                     <C>       <C>
[X]  PLEASE MARK YOUR VOTES AS IN THIS EXAMPLE.
1.   Proposal to elect one director.                                         [  ] FOR  [  ] WITHHELD
</TABLE>

<TABLE>
<S>  <C>
NOMINEE: Henri A. Termeer
</TABLE>

<TABLE>
<S>  <C>                                                      <C>                 <C>                 <C>
                                                                     FOR               AGAINST             ABSTAIN
2.   Proposal to amend the 1990 Equity Incentive Plan to             [  ]                [  ]                [  ]
     increase the number of shares of Genzyme Surgical
     Products common stock available for grant.
3.   Proposal to approve and adopt the amendment to the              [  ]                [  ]         [  ]
     Genzyme charter SUBJECT TO THE CONDITION THAT if the
     holders of less than a majority of any of the GZMO
     Stock, GZSP Stock or GZTR Stock outstanding and
     entitled to vote fail to approve and adopt the
     amendment, then the provisions of the proposed
     amendment (other than the provision contained at
     Article IV, Section G, governing generally all series
     of stock) shall not be adopted for that series.
</TABLE>
<TABLE>
<S>         <C>                         <C>    <C>                         <C>         <C>                         <C>
Signature:  -------------------------   Date:  -------------------------   Signature:  -------------------------   Date:
                                                                                       (if held jointly)

<S>         <C>
Signature:
</TABLE>

NOTE: Please sign exactly as your name appears on your stock certificate. When
shares are held by joint tenants, both should sign. When signing as attorney,
executor, administrator, trustee or guardian, please give full title as such. If
a corporation, please sign in full corporate name by authorized officer. If a
partnership, please sign in partnership name by authorized person.
<PAGE>
             ANNUAL MEETING OF STOCKHOLDERS OF GENZYME CORPORATION
                             THURSDAY, MAY 25, 2000
- --------------------------------------------------------------------------------
                           PROXY VOTING INSTRUCTIONS
- --------------------------------------------------------------------------------

TO VOTE BY MAIL
Please date, sign and mail your proxy card in the envelope provided as soon as
possible.

TO VOTE BY TELEPHONE (TOUCH-TONE PHONE ONLY)
Please call toll-free 1-800-PROXIES and follow the instructions. Have your
control number and the proxy card available when you call.

TO VOTE BY INTERNET
Please access the web page at "www.voteproxy.com" and follow the on-screen
instructions. Have your control number available when you access the web page.
- --------------------------------------------------------------------------------
YOUR CONTROL NUMBER IS:
- --------------------------------------------------------------------------------
<PAGE>
          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                GENZYME SURGICAL PRODUCTS DIVISION COMMON STOCK

    By signing this proxy, I appoint Henri A. Termeer, Michael S. Wyzga and
Peter Wirth, and each of them acting singly, my attorney and proxy, with full
power of substitution, to vote on my behalf all of the shares of Genzyme
Surgical Products Division common stock that I am entitled to vote at the Annual
Meeting of Stockholders to be held on May 25, 2000, and at any adjournments of
the meeting. This proxy revokes any earlier proxy I have signed with respect to
these shares.

    If properly executed, this proxy will be voted in the manner you specify. If
no specification is made, your shares of Genzyme Surgical Products stock will be
voted FOR each of the proposals. The proxies are authorized to vote your shares,
in their discretion, on any other matter that is properly brought before the
meeting.

                     PLEASE SIGN AND MAIL YOUR PROXY TODAY.

<TABLE>
<S>  <C>                                                                     <C>       <C>
[X]  PLEASE MARK YOUR VOTES AS IN THIS EXAMPLE.
1.   Proposal to elect one director.                                         [  ] FOR  [  ] WITHHELD
</TABLE>

<TABLE>
<S>  <C>
NOMINEE: Henri A. Termeer
</TABLE>

<TABLE>
<S>  <C>                                                      <C>                 <C>                 <C>
                                                                     FOR               AGAINST             ABSTAIN
2.   Proposal to amend the 1990 Equity Incentive Plan to             [  ]                [  ]                [  ]
     increase the number of shares of Genzyme Surgical
     Products common stock available for grant.
3.   Proposal to approve and adopt the amendment to the              [  ]                [  ]                [  ]
     Genzyme charter SUBJECT TO THE CONDITION THAT if the
     holders of less than a majority of any of the GZMO
     Stock, GZSP Stock or GZTR Stock outstanding and
     entitled to vote fail to approve and adopt the
     amendment, then the provisions of the proposed
     amendment (other than the provision contained at
     Article IV, Section G, governing generally all series
     of stock) shall not be adopted for that series.
</TABLE>
<TABLE>
<S>         <C>                         <C>    <C>                         <C>         <C>                         <C>
Signature:  -------------------------   Date:  -------------------------   Signature:  -------------------------   Date:
                                                                                       (if held jointly)

<S>         <C>
Signature:
</TABLE>

NOTE: Please sign exactly as your name appears on your stock certificate. When
shares are held by joint tenants, both should sign. When signing as attorney,
executor, administrator, trustee or guardian, please give full title as such. If
a corporation, please sign in full corporate name by authorized officer. If a
partnership, please sign in partnership name by authorized person.
<PAGE>
             ANNUAL MEETING OF STOCKHOLDERS OF GENZYME CORPORATION
                             THURSDAY, MAY 25, 2000
- --------------------------------------------------------------------------------
                           PROXY VOTING INSTRUCTIONS
- --------------------------------------------------------------------------------

TO VOTE BY MAIL

Please date, sign and mail your proxy card in the envelope provided as soon as
possible.

TO VOTE BY TELEPHONE (TOUCH-TONE PHONE ONLY)
Please call toll-free 1-800-PROXIES and follow the instructions. Have your
control number and the proxy card available when you call.

TO VOTE BY INTERNET
Please access the web page at "www.voteproxy.com" and follow the on-screen
instructions. Have your control number available when you access the web page.
- --------------------------------------------------------------------------------
YOUR CONTROL NUMBER IS:
- --------------------------------------------------------------------------------
<PAGE>
          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                  GENZYME TISSUE REPAIR DIVISION COMMON STOCK

    By signing this proxy, I appoint Henri A. Termeer, Michael S. Wyzga and
Peter Wirth, and each of them acting singly, my attorney and proxy, with full
power of substitution, to vote on my behalf all of the shares of Genzyme Tissue
Repair Division common stock that I am entitled to vote at the Annual Meeting of
Stockholders to be held on May 25, 2000, and at any adjournments of the meeting.
This proxy revokes any earlier proxy I have signed with respect to these shares.

    If properly executed, this proxy will be voted in the manner you specify. If
no specification is made, your shares of Genzyme Tissue Repair stock will be
voted FOR each of the proposals. The proxies are authorized to vote your shares,
in their discretion, on any other matter that is properly brought before the
meeting.

                     PLEASE SIGN AND MAIL YOUR PROXY TODAY.

<TABLE>
<S>  <C>                                                                     <C>       <C>
[X]  PLEASE MARK YOUR VOTES AS IN THIS EXAMPLE.
1.   Proposal to elect one director.                                         [  ] FOR  [  ] WITHHELD
</TABLE>

<TABLE>
<S>  <C>
NOMINEE: Henri A. Termeer
</TABLE>

<TABLE>
<S>  <C>                                                   <C>                 <C>                 <C>
                                                                  FOR               AGAINST             ABSTAIN
2.   Proposal to amend the 1990 Equity Incentive Plan to          [  ]                [  ]                [  ]
     increase the number of shares of Genzyme Surgical
     Products common stock available for grant.
3.   Proposal to approve and adopt the amendment to the           [  ]                [  ]                [  ]
     Genzyme charter SUBJECT TO THE CONDITION THAT if the
     holders of less than a majority of any of the GZMO
     Stock, GZSP Stock or GZTR Stock outstanding and
     entitled to vote fail to approve and adopt the
     amendment, then the provisions of the proposed
     amendment (other than the provision contained at
     Article IV, Section G, governing generally all
     series of stock) shall not be adopted for that
     series.
</TABLE>
<TABLE>
<S>         <C>                         <C>    <C>                         <C>         <C>                         <C>
Signature:  -------------------------   Date:  -------------------------   Signature:  -------------------------   Date:
                                                                                       (if held jointly)

<S>         <C>
Signature:
</TABLE>

NOTE: Please sign exactly as your name appears on your stock certificate. When
shares are held by joint tenants, both should sign. When signing as attorney,
executor, administrator, trustee or guardian, please give full title as such. If
a corporation, please sign in full corporate name by authorized officer. If a
partnership, please sign in partnership name by authorized person.
<PAGE>
             ANNUAL MEETING OF STOCKHOLDERS OF GENZYME CORPORATION
                             THURSDAY, MAY 25, 2000
- --------------------------------------------------------------------------------
                           PROXY VOTING INSTRUCTIONS
- --------------------------------------------------------------------------------

TO VOTE BY MAIL

Please date, sign and mail your proxy card in the envelope provided as soon as
possible.

TO VOTE BY TELEPHONE (TOUCH-TONE PHONE ONLY)

Please call toll-free 1-800-PROXIES and follow the instructions. Have your
control number and the proxy card available when you call.

TO VOTE BY INTERNET
Please access the web page at "www.voteproxy.com" and follow the on-screen
instructions. Have your control number available when you access the web page.
- --------------------------------------------------------------------------------
YOUR CONTROL NUMBER IS:
- --------------------------------------------------------------------------------
<PAGE>
          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                GENZYME MOLECULAR ONCOLOGY DIVISION COMMON STOCK

    By signing this proxy, I appoint Henri A. Termeer, Michael S. Wyzga and
Peter Wirth, and each of them acting singly, my attorney and proxy, with full
power of substitution, to vote on my behalf all of the shares of Genzyme
Molecular Oncology Division common stock that I am entitled to vote at the
Annual Meeting of Stockholders to be held on May 25, 2000, and at any
adjournments of the meeting. This proxy revokes any earlier proxy I have signed
with respect to these shares.

    If properly executed, this proxy will be voted in the manner you specify. If
no specification is made, your shares of Genzyme Molecular Oncology stock will
be voted FOR each of the proposals. The proxies are authorized to vote your
shares, in their discretion, on any other matter that is properly brought before
the meeting.

                     PLEASE SIGN AND MAIL YOUR PROXY TODAY.

<TABLE>
<S>  <C>                                                                     <C>       <C>
[X]  PLEASE MARK YOUR VOTES AS IN THIS EXAMPLE.
1.   Proposal to elect one director.                                         [  ] FOR  [  ] WITHHELD
</TABLE>

<TABLE>
<S>  <C>
NOMINEE: Henri A. Termeer
</TABLE>

<TABLE>
<S>  <C>                                                      <C>                 <C>                 <C>
                                                                     FOR               AGAINST             ABSTAIN
2.   Proposal to amend the 1990 Equity Incentive Plan to             [  ]                [  ]                [  ]
     increase the number of shares of Genzyme Surgical
     Products common stock available for grant.
3.   Proposal to approve and adopt the amendment to the              [  ]                [  ]                [  ]
     Genzyme charter SUBJECT TO THE CONDITION THAT if the
     holders of less than a majority of any of the GZMO
     Stock, GZSP Stock or GZTR Stock outstanding and
     entitled to vote fail to approve and adopt the
     amendment, then the provisions of the proposed
     amendment (other than the provision contained at
     Article IV, Section G, governing generally all series
     of stock) shall not be adopted for that series.
</TABLE>
<TABLE>
<S>         <C>                         <C>    <C>                         <C>         <C>                         <C>
Signature:  -------------------------   Date:  -------------------------   Signature:  -------------------------   Date:
                                                                                       (if held jointly)

<S>         <C>
Signature:
</TABLE>

NOTE: Please sign exactly as your name appears on your stock certificate. When
shares are held by joint tenants, both should sign. When signing as attorney,
executor, administrator, trustee or guardian, please give full title as such. If
a corporation, please sign in full corporate name by authorized officer. If a
partnership, please sign in partnership name by authorized person.
<PAGE>
             ANNUAL MEETING OF STOCKHOLDERS OF GENZYME CORPORATION
                             THURSDAY, MAY 25, 2000
- --------------------------------------------------------------------------------
                           PROXY VOTING INSTRUCTIONS
- --------------------------------------------------------------------------------

TO VOTE BY MAIL

Please date, sign and mail your proxy card in the envelope provided as soon as
possible.

TO VOTE BY TELEPHONE (TOUCH-TONE PHONE ONLY)

Please call toll-free 1-800-PROXIES and follow the instructions. Have your
control number and the proxy card available when you call.

TO VOTE BY INTERNET
Please access the web page at "www.voteproxy.com" and follow the on-screen
instructions. Have your control number available when you access the web page.
- --------------------------------------------------------------------------------
YOUR CONTROL NUMBER IS:
- --------------------------------------------------------------------------------


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