GENZYME CORP
SC 13D/A, 2000-04-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934

                                (Amendment No.1)(1)

                                   FOCAL, INC.
                                (Name of Issuer)

                          COMMON STOCK, $0.01 PAR VALUE
                         (Title of Class of Securities)

                                    343909107
                       ----------------------------------
                                 (CUSIP Number)
<TABLE>
       <S>                           <C>
       MICHAEL S. WYZGA              PAUL M. KINSELLA
       GENZYME CORPORATION           PALMER & DODGE LLP
       ONE KENDALL SQUARE            ONE BEACON STREET
       CAMBRIDGE, MA 02139           BOSTON, MA 02108
       (617) 252-7500                (617) 573-0100
</TABLE>
- --------------------------------------------------------------------------------
   (Name, Address and Telephone Number of Person Authorized to Receive Notices
                               and Communications)

                                 APRIL 14, 2000
                      ------------------------------------
             (Date of Event which Requires Filing of this Statement)

       If the filing person has previously filed a statement on Schedule 13G to
       report the acquisition which is the subject of this Schedule 13D, and is
       filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g),
       check the following box |_| .

       NOTE: Schedules filed in paper format shall include a signed original and
       five copies of the schedule, including all exhibits. SEE Rule 13d-7(b)
       for other parties to whom copies are to be sent.

                         (Continued on following pages)

                               (Page 1 of 5 pages)
       ------------------
       (1)The remainder of this cover page shall be filled out for a reporting
       person's initial filing on this form with respect to the subject class of
       securities, and for any subsequent amendment containing information which
       would alter disclosures provided in a prior cover page.

       The information required on the remainder of this cover page shall not be
       deemed to be "filed" for the purpose of Section 18 of the Securities
       Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
       that section of the Act but shall be subject to all other provisions of
       the Act (however, see the NOTES).


<PAGE>

                                  SCHEDULE 13D

- --------------------------------                         -----------------------
CUSIP NO. 343909107                                            Page 2 of 5 pages
          --------
- -------------------------------                          -----------------------

- --------------------------------------------------------------------------------
    1       NAME OF REPORTING PERSON
            GENZYME CORPORATION

            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
            06-1047163
- --------------------------------------------------------------------------------
    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF THE GROUP           (a) / /
                                                                         (b) / /
- --------------------------------------------------------------------------------
    3       SEC USE ONLY
- --------------------------------------------------------------------------------
    4       SOURCE OF FUNDS*
            WC
- --------------------------------------------------------------------------------
    5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
            TO ITEMS 2(d) OR 2(e) |_|
- --------------------------------------------------------------------------------
    6       CITIZENSHIP OR PLACE OF ORGANIZATION
            MASSACHUSETTS
- --------------------------------------------------------------------------------
         NUMBER OF SHARES              7     SOLE VOTING POWER
        BENEFICIALLY OWNED                   1,424,622
         BY EACH REPORTING
            PERSON WITH
                                    --------------------------------------------
                                       8     SHARED VOTING POWER
                                             0
                                    --------------------------------------------
                                       9     SOLE DISPOSITIVE POWER
                                             1,424,622
                                    --------------------------------------------
                                      10     SHARED DISPOSITIVE POWER
                                             0
- --------------------------------------------------------------------------------
    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
            1,424,622
- --------------------------------------------------------------------------------
    12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
               EXCLUDES CERTAIN SHARES*                                      / /
- --------------------------------------------------------------------------------
    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW(11)
            9.6%
- --------------------------------------------------------------------------------
    14      TYPE OR REPORT PERSON*
            CO
- --------------------------------------------------------------------------------

                                *SEE INSTRUCTIONS


<PAGE>

                                                               Page 3 of 5 pages

         This Amendment No. 1 amends and supplements the Statement on Schedule
13D initially filed by Genzyme Corporation, a Massachusetts corporation
("Genzyme"), with the Securities and Exchange Commission (the "Commission") on
November 8, 1999.

              Except as set forth below, there are no changes in the information
set forth in the Schedule 13D. Capitalized terms used but not otherwise defined
herein shall have the meaning ascribed to them in the Schedule 13D.

ITEM 2.       IDENTITY AND BACKGROUND.

         Item 2 is amended by replacing in its entirety the information
regarding the directors and executive officers of Genzyme that is set forth in
Exhibit 1 to the Schedule 13D and incorporated in such item by reference with
the information set forth in Exhibit 1 to this Amendment No. 1 on Schedule 13D
and incorporated herein by reference.

ITEM 3.       SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

         Item 3 is amended by inserting the following text at the end of such
item:

         On April 14, 2000, Genzyme purchased 614,250 shares (the "First Option
         Shares") of Common Stock for an aggregate purchase price of $4,999,995.
         The funds used in making the purchase came from Genzyme's working
         capital.

ITEM 5.       INTEREST IN SECURITIES OF THE ISSUER.

         Item 5 is amended by replacing such item in its entirety with the
following text:

         (a) Genzyme beneficially owns 1,424,622 shares of Common Stock,
representing 9.59% of the outstanding shares of Common Stock of the Issuer based
on 14,235,231 shares outstanding as of March 20, 2000. The Initial Shares were
acquired from the Issuer in a private placement on November 8, 1999 and the
First Option Shares were acquired from the Issuer in a private placement on
April 14, 2000 pursuant to the exercise by the Issuer of the first option
described in Item 4.

         (b) Genzyme has sole voting and investment power over the Initial
Shares and the First Option Shares.

         (c) Other than pursuant to the transactions described in Item 3 and
Item 4, neither Genzyme nor any director or executive officer of Genzyme has
acquired or disposed of any shares of Common Stock of the Issuer during the past
60 days.

         (d)      Not applicable.

         (e)      Not applicable.


<PAGE>

                                                               Page 4 of 5 pages

                                    SIGNATURE

         After reasonable inquiry and to the best of its knowledge and belief,
the undersigned certifies that the information set forth in this statement is
true, complete and correct.

Date: April 14, 2000                                GENZYME CORPORATION



                                             By: /s/ Michael S. Wyzga
                                                --------------------------------
                                                 Michael S. Wyzga
                                                 Senior Vice President, Finance;
                                                 Chief Financial Officer;
                                                 and Chief Accounting Officer


<PAGE>

                                                               Page 5 of 5 pages

                                  EXHIBIT INDEX


The Exhibit Index is amended by replacing the text of such Index in its entirety
with the following text:

<TABLE>
<S>               <C>
Exhibit 1:        Directors and Executive Officers of Genzyme.  Filed herewith.

Exhibit 2:        Stock Purchase Agreement dated as of October 23, 1999. Filed as
                  Exhibit 2 to Statement on Schedule 13D filed on November 8, 1999
                  (File No. 000-23247).

Exhibit 3:        Registration Rights Agreement dated as of October 21, 1999.
                  Filed as Exhibit 3 to Statement on Schedule 13D filed
                  on November 8, 1999 (File No. 000-23247).
</TABLE>



<PAGE>


                                                                       EXHIBIT I
DIRECTORS OF GENZYME

         Set forth below is the name, present principal occupation or employment
and the name, principal business and address of any corporation or other
organization in which such employment is conducted of each director of Genzyme.
Unless otherwise indicated, each director is a citizen of the United States.

         Henri A. Termeer
         Chairman of the Board, President and Chief Executive Officer
         Genzyme Corporation
         One Kendall Square
         Cambridge, Massachusetts  02139

         Constantine E. Anagnostopoulos
         Managing General Partner
         Gateway Associates (venture capital limited partnership)
         800 Maryland Avenue, Suite 1190
         St. Louis, MO  63105

         Douglas A. Berthiaume
         Chairman, President and Chief Executive Officer
         Waters Corporation (high technology manufacturer of products used for
           analysis and purification)
         34 Maple Street
         Milford, Massachusetts  01757

         Henry E. Blair
         Chairman and Chief Executive Officer
         Dyax Corp. (bioseparation, pharmaceutical discovery and development
           company)
         One Kendall Square, Building 600, 5th Floor
         Cambridge, Massachusetts  02139

         Robert J. Carpenter
         Chairman
         GelTex Pharmaceuticals, Inc.
         (biotechnology company)
         70 Walnut Street
         Wellesley, Massachusetts  02181

         Charles L. Cooney
         Professor of Chemical and Biochemical Engineering
         Massachusetts Institute of Technology
         25 Ames Street
         Building 66-Room 472
         Cambridge, Massachusetts  02139

<PAGE>

                                                                       EXHIBIT I

         Henry R. Lewis
         c/o Genzyme Corporation
         One Kendall Square
         Cambridge, Massachusetts 02139

EXECUTIVE OFFICERS OF GENZYME

         Set forth below is the name and present principal occupation of each of
the executive officers of Genzyme. Unless otherwise indicated, each executive
officer is a citizen of the United States and has as his principal business
address One Kendall Square, Cambridge, Massachusetts 02139.

         Henri A. Termeer
         Chairman of the Board, President and Chief Executive Officer

         Russell J. Campanello
         Senior Vice President, Human Resources

         Earl M. Collier, Jr.
         Executive Vice President; President, Surgical Products

         David D. Fleming
         Group Senior Vice President, Diagnostic Products and Genetics

         Michael S. Wyzga
         Senior Vice President, Chief Financial Officer and Chief Accounting
         Officer

         Richard A. Moscicki
         Senior Vice President, Clinical, Medical and Regulatory Affairs;
         Chief Medical Officer

         Alan E. Smith
         Senior Vice President, Research; Chief Scientific Officer
         Citizenship: United Kingdom

         G. Jan van Heek
         Executive Vice President, Therapeutics and Genetics
         Citizenship: The Netherlands

         Peter Wirth
         Executive Vice President, Legal, Corporate Development, Molecular
         Oncology and Pharmaceuticals; Chief Legal Officer





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