ALLIANCE PHARMACEUTICAL CORP
S-8, 1995-06-05
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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As filed with the Securities and Exchange Commission on June 2,
1995
                                                                

                               Registration Statement No. 33-
                    SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C. 20549
                                               

                                 FORM S-8
                       REGISTRATION STATEMENT UNDER
                        THE SECURITIES ACT OF 1933
                                               

                       ALLIANCE PHARMACEUTICAL CORP.
          (Exact name of registrant as specified in its charter)

                  New York                     14-1644018
        (State or other jurisdiction            (I.R.S. Employer
     of incorporation or organization)   Identification Number) 
                          3040 Science Park Road
                           San Diego, CA  92121
                              (619) 558-4300
          (Address, including zip code, and telephone number,
including area code of registrant's principal executive offices)

                          1991 STOCK OPTION PLAN
                         (Full title of the plan)
                (Formerly known as the 1991 NON-QUALIFIED 
                         STOCK OPTION PROGRAM)

                               DUANE J. ROTH
                                 President
                       Alliance Pharmaceutical Corp.
                          3040 Science Park Road
                           San Diego, CA  92121
                              (619) 558-4300
 (Name, address, including zip code, and telephone number, of
agent for service of process)
                                               

                                 Copy to:
                           Melvin Epstein, Esq.
                         Stroock & Stroock & Lavan
                           Seven Hanover Square
                         New York, NY  10004-2696
                                               

                      CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>
                                     Proposed     Proposed  
                                      Maximum      Maximum
Title of Shares                      Aggregate     Aggregate   Amount of     
to be               Amount to be     Price Per     Offering    Registration  
Registered          Registered       Unit (1)      Price       Fee  
<S>                 <C>           <C>          <C>             <C>
Common Stock,       1,000,000     $6.63 per 
$.01 par value.      shares        share       $6,630,000      $2,286.21
</TABLE>

     (1)  Estimated solely for the purposes of calculating the
          registration fee pursuant to Rule 457(h) on the basis
          of the last reported sale price of the Common Stock on
          the NASDAQ National Market System on May 31, 1995.

<PAGE>

     This Registration Statement on Form S-8 of Alliance
Pharmaceutical Corp., a New York corporation (the "Company"),
covers 1,000,000 shares of Common Stock, par value $.01 per
share, of the Company reserved for issuance under the Company's
1991 Stock Option Plan.  As permitted by
General Instruction E of Form S-8, the Company hereby
incorporates by reference the contents of the Company's
Registration Statement on Form S-8, dated February 13, 1992
(Registration No. 33-45683) filed under the 1933 Act.
<PAGE>


                                SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933,
the Registrant certifies that it has reasonable grounds to
believe that it meets all of the requirements for filing on Form
S-8 and has duly caused this Registration Statement to be signed
on its behalf by the undersigned, thereunto duly authorized, in
the City of San Diego, State of California, on June 2, 1995.

                            ALLIANCE PHARMACEUTICAL CORP.
                                    (Registrant)


Date: June 2, 1995                By  /s/ Duane J. Roth         

                                     Duane J. Roth
                                     President

                                     
     Pursuant to the requirements of the Securities Act of 1933,
this Registration Statement has been signed below by the
following persons in the capacities indicated on June 2, 1995.
 



/s/Duane J. Roth       President, Chief Executive
   Duane J. Roth       Officer and a Director       June 2, 1995
   (Chief Executive Officer)


/s/Theodore D. Roth    Executive Vice President
   Theodore D. Roth    and Chief Financial Officer  June 2, 1995
   (Chief Financial Officer)


/s/Tim T. Hart         Treasurer and Comptroller    June 2, 1995
   Tim T. Hart
   (Chief Accounting Officer)


   Carroll O. Johnson*    Director               June 2, 1995
   Carroll O. Johnson

   Stephen M. McGrath*    Director               June 2, 1995
   Stephen M. McGrath

   Donald E. O'Neill*     Director               June 2, 1995
   Donald E. O'Neill

   Dr. Helen M. Ranney*   Director               June 2, 1995
   Dr. Helen M. Ranney

   Dr. Jean G. Riess*     Director               June 2, 1995
   Dr. Jean G. Riess

   Dr. Thomas F. Zuck*    Director               June 2, 1995
   Dr. Thomas F. Zuck

*By:/s/ Theodore D. Roth                      
        Theodore D. Roth
        Attorney-in-Fact
<PAGE>
                               EXHIBIT INDEX
                                                    
Sequential
Exhibit                                            Page      
Number                  Description                Number    

5         Opinion of Stroock & Stroock & Lavan.             
24.1      Consent of Stroock & Stroock & Lavan (included in
          Exhibit 5 hereto).
24.2      Consent of Deloitte & Touche LLP.
24.3      Consent of Ernst & Young LLP.
25        Power of Attorney.

                                                EXHIBIT 5

            [LETTERHEAD OF STROOCK & STROOCK & LAVAN]
        
June 2, 1995

Alliance Pharmaceutical Corp.
3040 Science Park Road
San Diego, CA 92121

Re:  Alliance Pharmaceutical Corp.
     Registration Statement on Form S-8

Ladies and Gentlemen:

We have acted as counsel to you (the "Company") in connection
with the preparation and filing of the above-captioned
Registration Statement on Form S-8 (the "Registration
Statement") under the Securities Act of 1933, as
amended (the "Act"), covering 1,000,000 shares of the Company's
Common Stock, par value $.01 per share (the "Shares").  The
Shares are issuable pursuant to the Company's 1991 Stock Option
Plan (the "Plan"). 

We have examined copies of the Certificate of Incorporation and
By-laws of the Company, each as amended to date, the Plan, the
minutes of various meetings of the Board of Directors of the
Company and the original, photostatic or certified copies of all
such records of the Company, and all such agreements,
certificates of public officials, certificates of officers and
representatives of the Company or others, and such other
documents, papers, statutes and authorities as we deemed
necessary to form the basis of the opinions hereinafter
expressed.  In such examination, we have assumed the genuineness
of signatures and the conformity to original documents of the
documents supplied to us as copies.  As to various questions of
fact material to such opinions, we have relied upon
statements and certificates of officers of the Company and
others.

Based upon the foregoing, we are of the opinion that all of the
Shares covered by the Registration Statement have been duly
authorized and, when issued in accordance with the terms of the
Plan, will be validly issued, fully paid and nonassessable.

We hereby consent to your filing a copy of this opinion as an
exhibit to the Registration Statement.  In giving such
consent, we do not admit hereby that we come within the category
of persons whose consent is required under
Section 7 of the Act, or the rules and regulations of the
Securities and Exchange Commission thereunder.

Very truly yours,

/s/STROOCK & STROOCK & LAVAN
<PAGE>
                                           EXHIBIT 24.2

CONSENT OF DELOITTE & TOUCHE LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in this 
Registration Statement of Alliance Pharmaceutical Corp. on
Form S-8 of our report dated July 27, 1993, appearing in the
Annual Report on Form 10-K of Alliance Pharmaceutical Corp. (the
"Company") for the year ended June 30, 1994, as amended by the
Company's Amended Annual Report on Form 10-K/A filed March 7,
1995.


/s/ DELOITTE & TOUCHE LLP

New York, New York
May __, 1995
<PAGE>
                                              EXHIBIT 24.3

CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in Registration
Statement (Form S-8) pertaining to the 1991 Stock Option Plan of
Alliance Pharmaceutical Corp. of our report dated August 16,
1994, with respect to the consolidated financial statements and
schedule of Alliance Pharmaceutical Corp. included in its Annual
Report (Form 10-K), as amended by Form 10-K/A, for the year
ended June 30, 1994, filed with the Securities and Exchange
Commission. 

/s/ ERNST & YOUNG, LLP

San Diego, California
May __, 1995
<PAGE>
                                               EXHIBIT 25

                         POWER OF ATTORNEY

          KNOW ALL MEN BY THESE PRESENTS, that each person whose
signature appears below constitutes and appoints Duane J. Roth
and Theodore D. Roth, or either of them, his true and lawful
attorney-in-fact and agent, with full power of substitution and
resubstitution, for him and in his name, place and stead, in any
and all capacities, to sign a Registration Statement on Form S-8
(or an amendment to a previously filed Registration Statement on
Form S-8) or such other form as counsel to Alliance
Pharmaceutical Corp. (the "Corporation") may recommend in
connection with the registration of 1,000,000 shares of common
stock of the Corporation which may be issued to directors,
officers, employees and consultants of the Corporation, pursuant
to the 1991 Stock Option Plan of the Corporation as approved at
the annual meeting of shareholders held on November 14, 1994,
and any and all amendments to this registration statement, and
to file the same, with all exhibits thereto, and other
documents in connection therewith, with the Securities and
Exchange Commission, granting unto said attorney-in-
fact and agent full power and authority to do and perform each
and every act and thing requisite and necessary to
be done in and about the premises, as fully to all intents and
purposes as he might or could do in person, hereby
ratifying and confirming all that said attorney-in-fact, agent,
or their substitutes may lawfully do or cause to be done
by virtue hereof.

          IN WITNESS WHEREOF, each of the undersigned has caused
this power of attorney to be executed as of the date set forth
beside their name.


    /s/ Carroll O. Johnson    Director       April 1, 1995
        Carroll O. Johnson

    /s/ Stephen M. McGrath    Director       April 1, 1995
        Stephen M. McGrath

    /s/ Donald E. O'Neill     Director       April 1, 1995
        Donald E. O'Neill


    /s/ Helen M. Ranney       Director       March 31, 1995
        Helen M. Ranney, M.D.

    /s/ Jean Riess, Ph.D.     Director       April 1, 1995
        Jean Riess, Ph.D.

    /s/ Thomas F. Zuck, M.D.  Director       April 1, 1995
        Thomas F. Zuck, M.D.


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