ALLIANCE PHARMACEUTICAL CORP
S-8, 1997-04-25
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON APRIL 25, 1997
                                            REGISTRATION STATEMENT NO. 333-
=============================================================================
                                                 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   __________

                                    FORM S-8
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                   __________

                          ALLIANCE PHARMACEUTICAL CORP.
             (Exact name of registrant as specified in its charter)


                         NEW YORK                        14-1644018
              (State or other jurisdiction            (I.R.S. Employer
               of incorporation or organization)      Identification Number)
                             3040 SCIENCE PARK ROAD
                               SAN DIEGO, CA 92121
                                 (619) 558-4300
      (Address, including zip code, and telephone number, including area
      code of registrant's principal executive offices)

             EMPLOYEES' 401(K) PLAN OF ALLIANCE PHARMACEUTICAL CORP.
                            (Full title of the plan)

                                  DUANE J. ROTH
                                    President
                          Alliance Pharmaceutical Corp.
                             3040 Science Park Road
                               San Diego, CA 92121
                                 (619) 558-4300
     (Name, address, including zip code, and telephone number, of agent
     for service of process)

                                   __________

                                    COPY TO:
                              Melvin Epstein, Esq.
                          Stroock & Stroock & Lavan LLP
                                 180 Maiden Lane
                               New York, NY 10038

                                   __________

                         CALCULATION OF REGISTRATION FEE
                            
                                   Proposed       Proposed
                                   Maximum        Maximum
 Title of Shares                   Aggregate      Aggregate     Amount of
 to be             Amount to be    Price Per      Offering      Registration
 Registered        Registered      Unit (1)       Price         Fee
                           
 Common Stock,       9,779         $13.625 per
 $.01 par value.     shares        share          $133,238.88   $100.00
                           

(1)     As dictated by Rule 457(h)(1), the Proposed Maximum Aggregate
        Price Per Unit represents the amount per share at which the
        Company values its matching contribution under the Employees'
        401(k) Plan of Alliance Pharmaceutical Corp.

<PAGE>

         This Registration Statement on Form S-8 of Alliance Pharmaceutical
Corp., a New York corporation (the "Company"), covers 9,779 shares of Common
Stock, par value $.01 per share, of the Company reserved for issuance under the
Employees' 401(k) Plan of Alliance Pharmaceutical Corp. As permitted by General
Instruction E of Form S-8, the Company hereby incorporates by reference the
contents of the Company's Registration Statement on Form S-8, dated December 23,
1996 (Registration No. 333-18787) filed under the Securities Act of 1933, as
amended.


<PAGE>

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Diego, State of California, on April 25, 1997.

                                  ALLIANCE PHARMACEUTICAL CORP.
                                  (Registrant)


Date: April 25, 1997              By  /S/ DUANE J. ROTH
                                      --------------------------------------
                                      Duane J. Roth
                                      President


         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated on April 25, 1997.



   /S/DUANE J. ROTH           President, Chief Executive
      Duane J. Roth           Officer and a Director        April 25, 1997


   /S/THEODORE D. ROTH        Executive Vice President
      Theodore D. Roth        and Chief Financial Officer   April 25, 1997


   /S/TIM T. HART             Controller and Chief
      Tim T. Hart             Accounting Officer            April 25, 1997


   PEDRO CUATRECASAS, M.D.*   Director                      April 25, 1997
   Pedro Cuatrecasas, M.D.


   CARROLL O. JOHNSON*        Director                      April 25, 1997
   Carroll O. Johnson


   STEPHEN M. MCGRATH*        Director                      April 25, 1997
   Stephen M. McGrath


   DONALD E. O'NEILL*         Director                      April 25, 1997
   Donald E. O'Neill


   HELEN M. RANNEY, M.D.*     Director                      April 25, 1997
   Helen M. Ranney, M.D.


   JEAN G. RIESS, PH.D.*      Director                      April 25, 1997
   Jean G. Riess, Ph.D.


   THOMAS F. ZUCK, M.D.*      Director                      April 25, 1997
   Thomas F. Zuck, M.D.


  *By: /S/ THEODORE D. ROTH
       Theodore D. Roth
       Attorney-in-Fact


<PAGE>


                                  EXHIBIT INDEX


Exhibit
Number                   DESCRIPTION
- -------                  -----------

5                        Opinion of Stroock & Stroock & Lavan LLP.

23.1                     Consent of Stroock & Stroock & Lavan LLP 
                         (included in Exhibit 5 hereto).

23.2                     Consent of Ernst & Young LLP, independent auditors.

24                       Power of Attorney.




                                                              EXHIBIT 5

                  [LETTERHEAD OF STROOCK & STROOCK & LAVAN LLP]


April 25, 1997



Alliance Pharmaceutical Corp.
3040 Science Park Road
San Diego, CA 92121

Re:  Alliance Pharmaceutical Corp.
     Registration Statement on Form S-8
     ----------------------------------

Ladies and Gentlemen:

We have acted as counsel to you (the "Company") in connection with the
preparation and filing of the above-captioned Registration Statement on Form S-8
(the "Registration Statement") under the Securities Act of 1933, as amended (the
"Act"), covering 9,779 shares of the Company's Common Stock, par value $.01 per
share (the "Shares"). The Shares are issuable pursuant to the Employees' 401(k)
Plan of Alliance Pharmaceutical Corp. (the "Plan").

We have examined copies of the Certificate of Incorporation and By-laws of the
Company, each as amended to date, the Plan, the minutes of various meetings of
the Board of Directors of the Company and the original, photostatic or certified
copies of all such records of the Company, and all such agreements, certificates
of public officials, certificates of officers and representatives of the Company
or others, and such other documents, papers, statutes and authorities as we
deemed necessary to form the basis of the opinions hereinafter expressed. In
such examination, we have assumed the genuineness of signatures and the
conformity to original documents of the documents supplied to us as copies. As
to various questions of fact material to such opinions, we have relied upon
statements and certificates of officers of the Company and others.

Based upon the foregoing, we are of the opinion that all of the Shares covered
by the Registration Statement have been duly authorized and, when issued in
accordance with the terms of the Plan, will be validly issued, fully paid and
nonassessable.

We hereby consent to your filing a copy of this opinion as an exhibit to the
Registration Statement. In giving such consent, we do not admit hereby that we
come within the category of persons whose consent is required under Section 7 of
the Act, or the rules and regulations of the Securities and Exchange Commission
thereunder.

Very truly yours,



/s/STROOCK & STROOCK & LAVAN LLP


                                                               EXHIBIT 23.1

                          Included in Exhibit 5 hereto

                                                           EXHIBIT 23.2


               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement (Form
S-8) pertaining to the Employees' 401(k) Plan of Alliance Pharmaceutical Corp.
of our report dated July 18, 1996, with respect to the consolidated financial
statements of Alliance Pharmaceutical Corp. included in its Annual Report (Form
10-K), for the year ended June 30, 1996, filed with the Securities and Exchange
Commission.



/s/ ERNST & YOUNG LLP

San Diego, California
April 23, 1997



                                                                EXHIBIT 24

                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Duane J. Roth and Theodore D. Roth, or
either of them, his true and lawful attorney-in-fact and agent, with full power
of substitution and resubstitution, for him and in his name, place and stead, in
any and all capacities, to sign a registration statement on Form S-8 (or an
amendment to a previously filed registration statement on Form S-8) or such
other form as counsel to Alliance Pharmaceutical Corp. (the "Corporation") may
recommend in connection with the registration of common stock of the Corporation
issued to employees of the Corporation as of December 31, 1996, pursuant to the
Corporation's 401(k) Plan, and any and all amendments to this registration
statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission,
 granting unto said attorney-in-fact and agent full power and authority to do
and perform each and every act and thing requisite and necessary to be done in
and about the premises, as fully to all intents and purposes as he might or
could do in person, hereby ratifying and confirming all that said
attorney-in-fact, agent, or their substitutes may lawfully do or cause to be
done by virtue hereof.

         IN WITNESS WHEREOF, each of the undersigned has caused this power of
attorney to be executed as of the date set forth beside their name.


/S/ PEDRO CUATRECASAS, M.D.         Director           April 25, 1997
    Pedro Cuatrecasas, M.D


/S/ CARROLL O. JOHNSON              Director           April 25, 1997
    Carroll O. Johnson


/S/ STEPHEN M. MCGRATH              Director           April 25, 1997
    Stephen M. McGrath


/S/ DONALD E. O'NEILL               Director           April 25, 1997
    Donald E. O'Neill


/S/ HELEN M. RANNEY, M.D.           Director           April 25, l997
    Helen M. Ranney, M.D.


/S/ JEAN RIESS, PH.D.               Director           April 25, 1997
    Jean Riess, Ph.D.


/S/ THOMAS F. ZUCK, M.D.            Director           April 25, 1997
   Thomas F. Zuck, M.D.



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