NASTECH PHARMACEUTICAL CO INC
S-8, EX-5, 2000-09-20
PHARMACEUTICAL PREPARATIONS
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                                                                       EXHIBIT 5

                          [LETTERHEAD OF BRUCE R.THAW]

                                           September 19, 2000

Nastech Pharmaceutical Company Inc
45 Davids Drive
Hauppauge, NY 11788

            Re: Registration Statement on Form S-8

Ladies and Gentlemen:

      We have acted as counsel to Nastech Pharmaceutical Company Inc., a
Delaware corporation (the "Company"), in connection with a registration
statement on Form S-8 filed with the Securities and Exchange Commission (the
"Registration Statement") pertaining to the registration of up to 700,000 shares
of its Common Stock, $0.006 par value (the "Common Stock"), for issuance and
sale pursuant to the Company's 2000 Nonqualified Stock Option Plan (the "Plan").

      In that connection, we have examined originals or copies of such
documents, corporate records and other instruments as we have deemed necessary
or appropriate for purposes of this opinion including, but not limited to, the
following: (i) the Registration Statement; (ii) the Articles of Incorporation
and the Bylaws of the Company, as amended and as currently in effect; (iii) the
Plan; (iv) certain resolutions of the Board of Directors of the Corporation
relating to the issuance of the Common Stock and the other transactions
contemplated by the Registration Statement; and (v) such other documents as we
have deemed necessary or appropriate as a basis for the opinion set forth below.
We have assumed, without independent verification, the genuineness of
signatures, the authenticity of documents and the conformity with originals of
copies.

      Based on the foregoing, we are of the opinion that the Common Stock, when
issued and sold in accordance with the terms of the Plan, will be validly
issued, fully paid and non-assessable.

      We are members of the Bar of the State of New York and the opinions
expressed herein are limited to the corporate laws of Delaware pertaining to
matters such as the issuance of stock, but not including the "securities" or
"blue sky" law of Delaware.

      We hereby consent to the use of this opinion as an exhibit to the
Registration Statement. By giving the foregoing consent, we do not admit that we
come within the category of persons whose consent is required under Section 7 of
the Securities Act of 1933.

                  Very truly yours,



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