ELAN CORP PLC
SC 13D, 1996-06-05
PHARMACEUTICAL PREPARATIONS
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                          UNITED STATES
               SECURITIES AND EXCHANGE COMMISSION
                     Washington, D.C. 25049

                          SCHEDULE 13D

            Under the Securities Exchange Act of 1934
                        (Amendment No. 2)

                           Athena Neurosciences, Inc.            
- ----------------------------------------------------------------------------
                        (Name of Issuer)

                          Common Stock, $.01 par value           
- -----------------------------------------------------------------------------
                 (Title of Class of Securities)

                                 046854105                       
- -----------------------------------------------------------------------------
                         (CUSIP Number)

            William F. Daniel, Elan Corporation, plc
              Monksland, Athlone, County Westmeath,
                           Ireland, 011-353-902-94666            
- ------------------------------------------------------------------------------

(Name, Address and Telephone Number of Person Authorized to
Receive Notices
                       and Communications)

                                May 31, 1996                     
- ------------------------------------------------------------------------------
     (Date of Event which Requires Filing of this Statement)


If the filing person has previously filed a statement on Schedule
13G to report the acquisition which is the subject of this
Schedule 13D, and is filing this schedule because of Rule
13d-1(b)(3) or (4), check the following box /_/.

Check the following box if a fee is being paid with the statement
/ /.  (A fee is not required only if the reporting person:  (1)
has a previous statement on file reporting beneficial ownership
of more than five percent of the class of securities described in
Item 1; and (2) has filed no amendment subsequent thereto
reporting beneficial ownership of five percent or less of such
class.)  (See Rule 13d-7.)

Note:  Six copies of this statement, including all exhibits,
should be filed with the Commission.  See Rule 13d-1(a) for other
parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment
containing information which would alter disclosures provided in
a prior cover page.

The information required on the remainder of this cover page
shall not be deemed to be "filled" for the purpose of Section 18
of the Securities Exchange Act of 1934 ("Act") or otherwise
subject to the liabilities of that section of the Act but shall
be subject to all other provisions of the Act (however, see the
Notes).




<PAGE>
CUSIP No. 046854105

1.    NAME OF REPORTING PERSON
      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE
      PERSON

                  Elan Corporation, plc
                  

2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A
      GROUP*                                                           (a) /_/

                        N/A                                                
                                                                       (b) /_/

3.    SEC USE ONLY




4.    SOURCE OF FUNDS

                        WC
                                                                            __
5.    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS                      /_/
      REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)

                        N/A

6.    CITIZENSHIP OR PLACE OF ORGANIZATION

                  Ireland

7.    SOLE VOTING POWER

                  2,400,000 (assuming (i) the conversion
                  of a convertible note into 1,200,000
                  shares of Common Stock and (ii) the
                  exercise of two warrants for 400,000
                  and 500,000 shares of Common Stock,
                  respectively)

8.    SHARED VOTING POWER

                  NONE

9.    SOLE DISPOSITIVE POWER

                  2,400,000 (assuming (i) the conversion
                  of a convertible note into 1,200,000
                  shares of Common Stock and (ii) the
                  exercise of two warrants for 400,000
                  and 500,000 shares of Common Stock,
                  respectively)


10.   SHARED DISPOSITIVE POWER

                  NONE
<PAGE>
11.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
      REPORTING PERSON

                  2,400,000 (assuming (i) the conversion
                  of a convertible note into 1,200,000
                  shares of Common Stock and (ii) the
                  exercise of two warrants for 400,000
                  and 500,000 shares of Common Stock,
                  respectively)



                                                                            __
12.   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11)
      EXCLUDES                                                             /_/
      CERTAIN SHARES

                  NONE

13.   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
      (11)

                  8.0% (assuming (i) the conversion of a
                  convertible note into 1,200,000 shares
                  of Common Stock and (ii) the exercise
                  of two warrants for 400,000 and
                  500,000 shares of Common Stock,
                  respectively)


14.   TYPE OF REPORTING PERSON

                  CO
<PAGE>
            This Amendment No. 2 is filed on behalf of Elan
Corporation plc, a public limited company organized and
existing under the laws of Ireland ("Elan"), and amends
the Schedule 13D dated February 23, 1996 and as amended
on March 22, 1996 (the "Schedule 13D"), filed by Elan
with respect to the Common Stock, par value $.01 per
share (the "Common Stock"), of Athena Neurosciences,
Inc., a Delaware corporation (the "Issuer").  This
Amendment No. 2 to the Schedule 13D hereby amends Items
3, 5, 6 and 7 of such Schedule 13D.  Unless otherwise
indicated, all capitalized terms used but not defined
herein shall have the meaning set forth in such Schedule
13D.

Item 3.     Sources and Amount of Funds or Other
Consideration

            No changes except for the addition of the
following:

            On May 31, 1996, Elan, the Issuer and
PaineWebber R&D Partners III, L.P., a limited partnership
organized and existing under the laws of the state of
Delaware ("PaineWebber L.P.") entered into a Purchase and
Assignment Agreement whereby Elan purchased from
PaineWebber L.P. a warrant (the "PaineWebber Warrant") to
purchase 500,000 shares of the Common Stock of the Issuer
and certain rights to a potential product of the Issuer
for an aggregate purchase price of $6,000,000.  The
PaineWebber Warrant is not exercisable, if at all, until
the earlier of (i) the occurrence of certain specified
events or (ii) March 1, 1998.   The exercise price for
the PaineWebber Warrant is the lesser of (a) $8.20 per
share or (b) the average of the closing prices for the
Common Stock of the Issuer for the 60 consecutive days
during which the Nasdaq National Market is open for
business immediately preceding the first day on which the
PaineWebber Warrant could be exercised.  The source of
funds for the purchase by Elan of the PaineWebber Warrant
and those certain rights referenced above was working
capital.


Item 5.     Interest in the Securities of the Issuer

            Subsections (a), (b) and (c) of Item 5 are
hereby amended and restated in their entirety as follows:

            (a)   As of the date hereof, based upon the
number of shares of Common Stock of the Issuer
outstanding as of May 9, 1996, as set forth in the
Prospectus-Proxy Statement dated May 17, 1996 of Elan and
the Issuer, Elan beneficially owns 2,400,000 shares of
Common Stock of the Issuer, representing approximately
8.0% of the total outstanding shares of Common Stock of
the Issuer, including (i) 1,200,000 shares of Common
Stock which Elan Pharma has the right to acquire pursuant
to the convertible note, (ii) 400,000 shares of Common
Stock which Elan International has the right to acquire
pursuant to the Warrant and (iii) 500,000 shares of
Common Stock which Elan has the right to acquire under
certain circumstances pursuant to the PaineWebber
Warrant.  Except as disclosed in this Item 5(a), neither
Elan, nor, to the best of Elan's knowledge, any other
person named in Item 2 of Amendment No. 1 to the Schedule
13D filed on March 22, 1996 beneficially owns any of the
Issuer's Common Stock.
<PAGE>
                                     -2-



            (b)   To the best knowledge of Elan, it has sole
power to vote or direct the vote and to dispose of or
direct the disposition of all of the shares of Common
Stock beneficially owned by it.

            (c)   No transaction in the Common Stock has
occurred involving any person named in paragraph (a)
above during the past 60 days, other than the execution
of the Purchase Agreement described in items 3 and 4 of
Amendment No. 1 to the Schedule 13D filed on March 22,
1996 and the purchase of the PaineWebber Warrant
described in Item 3 above.


Item 6.     Contracts, Arrangements, Understandings
            or Relationships with Respect to
            Securities of the Issuer               

            Item 6 is amended and restated in its entirety
as follows:

            There is no contract, arrangement,
understanding or relationship between Elan or any of its
executive officers or directors, or to the best knowledge
of Elan, among such persons and any other person with
respect to any securities of the Issuer, except as set
forth elsewhere herein with respect to the Merger
Agreement, the Loan Agreement, the Warrant and the
PaineWebber Warrant.


Item 7.     Material to be Filed as Exhibits

            No changes except the addition of the
following:

            Exhibit 2      Purchase and Assignment Agreement by and
                           among Elan, the Issuer and PaineWebber
                           L.P.
                           dated May 31, 1996.




<PAGE>
                                    -3-



                                  SIGNATURE


            After reasonable inquiry and to the best of my
knowledge and belief, I certify that the information set forth in
this Schedule 13D is true, complete and correct.

Dated:  June 5, 1996

                                    ELAN CORPORATION, PLC.


                                    By:     Thomas G. Lynch          
                                        -------------------------------
                                       Name:  Thomas G. Lynch
                                       Title: Executive Vice
                                              President and Chief
                                              Financial Officer









































<PAGE>



                                Exhibit Index

            Exhibit 2      Purchase and Assignment Agreement by and
                           among Elan, the Issuer and PaineWebber
                           L.P. dated May 31, 1996.


<PAGE>
                      PURCHASE AND ASSIGNMENT AGREEMENT


            THIS AGREEMENT, made as of May 31, 1996 (the "Effective
Date"), among ATHENA NEUROSCIENCES, INC., a corporation organized
and existing under the laws of the State of Delaware ("Athena"),
PAINEWEBBER R&D PARTNERS III, L.P., a limited partnership
organized and existing under the laws of the State of Delaware
(the "Fund") and Elan Corporation, plc., a public limited company
existing under the laws of Ireland ("Elan"):


                        W I T N E S S E T H  T H A T:

            WHEREAS, the Fund is the holder of a Warrant No. CO-1
and a Warrant No. CA-1 each for the purchase of 500,000 Shares of
Common Stock of Athena (respectively the "Core Warrant" and the
"Callable Warrant") and a party to the Agreements (as defined in
Section 1.5 hereof) with Athena;

            WHEREAS, the Fund desires to sell, transfer and assign
its rights, title and interest to the Callable Warrant and the
Agreements and Elan desires to purchase, acquire and assume such
rights, title and interest;

            WHEREAS, the Fund will deliver the Callable Warrant to
Elan and Athena will consent to such assignment of the Callable
Warrant and the Agreements simultaneously with the signing
hereof;

            WHEREAS, Elan will pay to the Fund on the date hereof
the sum of Six Million Dollars ($6,000,000);

            NOW, THEREFORE, in consideration of the mutual
covenants expressed herein, and other good and valuable
consideration, the receipt and adequacy of which are hereby
acknowledged, Athena, the Fund and Elan agree as follows:

                                  ARTICLE I

                        ASSIGNMENT AND ASSUMPTION AND
                 PURCHASE AND SALE OF WARRANT AND AGREEMENTS

1.1.   Subject to Section 1.6 below, simultaneously with the
       execution and delivery hereof, upon the terms and subject
       to the conditions set forth herein and in reliance upon the
       representations and warranties contained herein, the Fund
       hereby sells, transfers and assigns to Elan, and Elan
       hereby purchases, assumes and acquires from the Fund all of
       the Fund's right, title and interest in and obligations
       under the Callable Warrant and the Agreements in
       consideration of the payment of the Purchase Price (as
       defined in Section 1.3) by Elan to the Fund.

1.2.   Simultaneously with the execution and delivery hereof, the
       Fund will deliver to Elan the warrant certificate
       representing the Callable Warrant and Athena will consent
       to the assignment of the Callable Warrant and the
       Agreements by the Fund to Elan.
<PAGE>
                                     -2-



1.3.   Simultaneously with the execution and delivery hereof, Elan
       will pay to the Fund a purchase price (the "Purchase
       Price") equal to six million dollars ($6,000,000) by means
       of a wire transfer made in accordance with the instructions
       provided by the Fund.

1.4.   Subject to Section 1.6 below, simultaneously with the
       execution and delivery hereof, all references to the Fund
       within the Callable Warrant and each of the Agreements
       other than the Program Agreement shall be references to
       Elan or its designee, and Elan shall succeed to all of the
       rights and assume all of the obligations of the Fund under
       the callable Warrant and the Agreements.

1.5.   As used in this Agreement, the term the "Agreements" shall
       mean collectively the Program Agreement between Athena and
       the Fund, dated November 17, 1994 (the "Program
       Agreement"), the Development Agreement between Athena and
       the Fund, dated November 17, 1994, the Technology Agreement
       between Athena and the Fund, dated November 17, 1994, and
       the Purchase Option Agreement between Athena and the Fund
       dated November 17, 1994 (the "Purchase Option Agreement").

1.6.   Nothing in this Agreement shall be deemed to affect the
       Fund's rights and obligations with respect to the Core
       Warrant and the Common Stock issuable thereunder, whether
       arising under the Core Warrant or the Program Agreement,
       and Elan and Athena will not amend the Program Agreement in
       any manner adverse to such rights and obligations without
       the prior written consent of the Fund.

                                     ARTICLE II

                               AGREEMENTS AND CONSENTS
                                      OF ATHENA

2.1.   Pursuant to Section 8.4(b) of the Program Agreement, Athena
       hereby consents to and approves the assignment and sale by
       the Fund of the Callable Warrant and the Agreements to
       Elan.

2.2.   Athena hereby agrees to indemnify Elan to the same extent
       it indemnified the Fund pursuant to Appendix B of the
       Program Agreement.

2.3    Athena hereby agrees to recognize Elan for all purposes as
       the valid assignee as of the Effective Date under the
       Callable Warrant and the Agreements.


                                     ARTICLE III

                           REPRESENTATIONS AND WARRANTIES

3.1.   Representations and Warranties of the Fund.

           (a)   Capacity, Authority and Validity.  The Fund has
       the full right, power and capacity to execute, deliver and
       perform this Agreement, and all requisite partnership
       action necessary to authorize the execution, delivery and
       performance by the Fund of this Agreement has been duly
       taken and no approval of, filing with, or other action by or
<PAGE>
                                     -3-



       in respect of, any governmental body, agency or official is
       required in connection with the execution, delivery and
       performance of this Agreement by the Fund.  This Agreement
       constitutes a valid and binding agreement of the Fund and
       is enforceable against the Fund in accordance with its
       terms.

           (b)   Non-Contravention.  The execution, delivery and
       performance by the Fund of this Agreement will not violate,
       conflict with, or constitute a default under, the Fund's
       agreement or certificate of limited partnership or the
       terms and provisions of any material agreement, license,
       trust, indenture, mortgage or other instrument or
       restriction to which the Fund is party or by which it or
       any of its assets or property may be bound, or any statute,
       law, rule, regulation, judgment, decree, order, award, writ
       or injunction applicable to the Fund or any of its assets
       or property.

           (c)   Valid Title.  The Fund has, as of the date hereof,
       valid, good and marketable title to the Callable Warrant
       free and clear of any lien, claim or encumbrance (except as
       contained in the Purchase Option Agreement) and can assign
       the Agreements free and clear of any lien, claim or
       encumbrance (except as contained in the Purchase Option
       Agreement).

           (d)   No Violations.  To the best of its knowledge, the
       Fund is not in violation of the Callable Warrant or the
       Agreements.

3.2.   Representations and Warranties of Elan.

           (a)   Capacity, Authority and Validity.  Elan has the
       full right, power and capacity to execute, deliver and
       perform this Agreement, and all requisite corporate action
       necessary to authorize the execution, delivery and
       performance by Elan of this Agreement has been duly taken
       and no approval of, filing with, or other action by or in
       respect of, any governmental body, agency or official is
       required in connection with the execution, delivery and
       performance of this Agreement by Elan.  This Agreement
       constitutes a valid and binding agreement of Elan and is
       enforceable against Elan in accordance with its terms.

           (b)   Non-Contravention.  The execution, delivery and
       performance by Elan of this Agreement will not violate,
       conflict with, or constitute a default under, Elan's
       articles of association or the terms and provisions of any
       material agreement, license, trust, indenture, mortgage or
       other instrument or restriction to which Elan is party or
       by which it or any of its assets or property may be bound,
       or any statute, law, rule, regulation, judgment, decree,
       order, award, writ or injunction applicable to Elan or any
       of its assets or property, and (except as contained in the
       Purchase Option Agreement) will not result in the creation
       of any lien, claim or encumbrance upon any property or
       assets of Elan.

3.3.   Representations and Warranties of Athena

           (a)   Capacity; Authority; Validity.  Athena has the
       full right, power and capacity to execute, deliver and
       perform this Agreement and all requisite corporate action
       necessary to authorize the execution,

<PAGE>
                                 -4-



       delivery and performance by Athena of this Agreement has
       been duly taken and no approval of, filing with, or other
       action by or in respect of, any governmental body, agency
       or official is required in connection with the execution,
       delivery and performance of this Agreement by Athena.  This
       Agreement constitutes a valid and binding agreement of
       Athena and is enforceable against Athena in accordance with
       its terms.

           (b)   Non-Contravention.  The execution, delivery and
       performance by Athena of this Agreement does not impair,
       violate, conflict with, or constitute a default under, the
       charter or bylaws of Athena or any material agreement,
       license, trust, indenture, mortgage or other instrument or
       restriction to which Athena is a party or by which Athena
       or any assets or property of Athena may be bound, or any
       statute, law, rule, regulation, judgment, decree, order,
       award, writ or injunction applicable to Athena, or any
       assets or property of Athena and (except as contained in
       the Purchase Option Agreement) will not result in the
       creation of any lien, claim or encumbrance upon any
       property or assets of Athena.  Other than any consent by
       Elan under the Agreement and Plan of Merger among Elan,
       Athena and Elan Acquisition Corp. (which consent is hereby
       given by Elan by entering this Agreement), no consents,
       approvals, waivers, authorizations or filings are required
       from any Person in connection with the execution, delivery
       and performance of this Agreement except those which have
       previously been obtained and are in full force and effect.

           (c)   Corporate Existence; Qualification.  Athena is a
       corporation duly organized, validly existing and in good
       standing under the laws of the State of Delaware and has
       all requisite corporate power and authority to own and
       lease its assets and property and to conduct its business,
       as at present conducted and as contemplated hereby and is
       duly licensed or qualified and in good standing in each
       jurisdiction in which the conduct of its business or the
       ownership or leasing of its assets and property makes such
       licensing or qualification necessary, except in those
       jurisdictions where the failure to so qualify would not
       have a material adverse effect on the business, assets,
       financial condition, results of operations or prospects of
       Athena.

           (d)   No Violations.  Athena is not in violation of any
       of the provisions of the Callable Warrant or the
       Agreements.


                                     ARTICLE IV

                                    MISCELLANEOUS

4.1.   Counterparts.  This Agreement may be executed in
       counterparts, each of which shall be deemed an original
       instrument but all of which taken together shall constitute
       one and the same agreement.

4.2.   Severability.  If any provision of this Agreement, or the
       application of any such provision to any person or
       circumstance, shall be held to be inconsistent with any
       present or future law, ruling, rule, or regulation of any
       court or governmental or regulatory authority having
       jurisdiction over the subject matter of this Agreement,
       such provision
<PAGE>
                                   -5-



       shall be deemed to be rescinded or modified in accordance
       with such law, ruling, rule, or regulation, and the
       remainder of this Agreement, or the application of such
       provision to persons or circumstances other than those as
       to which it is held inconsistent, shall not be affected
       thereby.

4.3.   Captions.  The captions in this Agreement are inserted for
       convenience of reference only, and shall not affect the
       interpretation or construction of any of the terms hereof.

4.4.   Entire Agreement.  This Agreement sets forth and
       constitutes the entire Agreement among Athena, Elan and the
       Fund with respect to the subject matter discussed herein
       and supersedes any and all prior agreements,
       understandings, promises and representations made by any
       party hereto.

4.5.   Amendments.  This Agreement may not be amended or modified
       in any manner except in writing signed by a duly authorized
       officer of Athena and Elan and, in the case of the Fund, a
       duly authorized officer of the General Partner.




































<PAGE>



            IN WITNESS WHEREOF, the parties hereto have duly
executed and delivered this Agreement as of the date first
written above.

                                    ATHENA NEUROSCIENCES, INC.:


                                    /s/ John Groom                 
                                    --------------------------------------
                                    Name:  John Groom
                                    Title: President and Chief
                                           Executive Officer


                                    ELAN CORPORATION, plc.:


                                    /s/ Thomas G. Lynch            
                                    ---------------------------------------
                                    Name:  Thomas G. Lynch
                                    Title: Executive Vice President
                                           and Chief Financial Officer


                                    PAINEWEBBER R&D PARTNERS III, L.P.,
                                    a limited partnership

                                    By:  PAINEWEBBER DEVELOPMENT
                                          CORPORATION, its sole 
                                          general partner


                                    /s/ Richard F. McCormick        
                                    ---------------------------------------
                                    Name:  Richard F. McCormick
                                    Title: Vice President





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