ELAN CORP PLC
SC 13D, 1998-11-12
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934

                                CYTEL CORPORATION
- -------------------------------------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.01 par value
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    23282E100
- -------------------------------------------------------------------------------
                                 (CUSIP Number)

                                  Kevin Insley
                        Elan International Services Ltd.
                               102 St. James Court
                           Flatts Smiths, FL04 Bermuda
                                 (441) 292-9169

                                    Copy to:
                            Lisabeth F. Murphy, Esq.
                           Athena Neurosciences, Inc.
                              800 Gateway Boulevard
                      South San Francisco, California 94080
                                 (650) 877-0900
                            Telecopy: (650) 875-3620
- -------------------------------------------------------------------------------
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                 August 12, 1998
- -------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of ss.ss. 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the
following box / /.

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See ss. 240.13d-7(b) for other
parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


                               Page 1 of 11 Pages
<PAGE>


                                  SCHEDULE 13D

- -------------------------------------------------------------------------------

CUSIP No. 23282E100

- -------------------------------------------------------------------------------
1         NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES
             ONLY)
          Elan International Services Ltd.
- -------------------------------------------------------------------------------
          I.R.S. Employer Identification No.: NA
- -------------------------------------------------------------------------------
2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a) / /
                                                              (b) / /
          N/A
- -------------------------------------------------------------------------------
3         SEC USE ONLY

- -------------------------------------------------------------------------------
4         SOURCE OF FUNDS

- -------------------------------------------------------------------------------
          WC
- -------------------------------------------------------------------------------
5         CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)  N/A

- -------------------------------------------------------------------------------
6         CITIZENSHIP OR PLACE OF ORGANIZATION

          Bermuda
- -------------------------------------------------------------------------------
                             7         SOLE VOTING POWER

        NUMBER OF                      2,000,000
         SHARES              __________________________________________________
       BENEFICIALLY          8         SHARED VOTING POWER
         OWNED BY
           EACH
        REPORTING            __________________________________________________
       PERSON WITH           9         SOLE DISPOSITIVE POWER

                                       2,000,000
                             --------------------------------------------------
                             10        SHARED DISPOSITIVE POWER

- -------------------------------------------------------------------------------
11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            2,000,000
- -------------------------------------------------------------------------------
12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES                                                  / /
- -------------------------------------------------------------------------------
13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          6.0 (based upon outstanding common stock as of June 30, 1998)
- -------------------------------------------------------------------------------
14        TYPE OF REPORTING PERSON

          CO
- -------------------------------------------------------------------------------


                               Page 2 of 11 Pages
<PAGE>


Item 1.  Security and Issuer.

     This statement relates to the Common Stock, $.01 par value (the "Common
Shares"), of Cytel Corporation (the "Issuer"), a Delaware Corporation, whose
principal executive offices are located at 3525 Johns Hopkins Court, San Diego,
California 92121.

Item 2.  Identity and Background.

     This Form 13-D is filed on behalf of Elan International Services Ltd.
("EIS"), a Bermuda corporation and a wholly-owned subsidiary of Elan
Corporation, plc ("Elan"), a public limited company organized and existing under
the laws of Ireland. EIS provides financial services to Elan.

     Elan is an integrated worldwide drug delivery and biopharmaceutical
company. The principal business and office address of Elan is: Lincoln House,
Lincoln Place, Dublin 2, Ireland and the principal business and office address
of EIS is: 102 St. James Court, Flatts Smiths, FL04 Bermuda. Information as to
the name, business address, present principal occupation or employment and
organization in which such occupation or employment is conducted and citizenship
of each director, executive officer and controlling person of Elan and EIS is
annexed hereto as Schedules A and B, respectively, and is incorporated herein by
reference.

     Neither Elan or EIS nor, to the best of Elan's or EIS's knowledge, any of
the persons listed on Schedules A and B hereto, has during the last five years
(i) been convicted in a criminal proceeding (excluding traffic violations or
similar misdemeanors) or (ii) been a party to a civil proceeding of a judicial
or administrative body of competent jurisdiction and as a result of such
proceeding was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

Item 3.  Sources and Amount of Funds or Other Consideration.

     In connection with a Sublicense and Option Agreement, dated as of July 22,
1998, as amended and restated on November 10, 1998, between EIS and the Issuer
(the "Sublicense Agreement"), and a Stock Purchase Agreement, dated as of July
22, 1998, between EIS and the Issuer (the "Stock Purchase Agreement"), on August
12, 1998 EIS purchased 2,000,000 Common Shares at $2.00 per share from the
Issuer in a private transaction. The source of funds for the purchase of the
Common Shares was provided by EIS's general corporate funds.


                               Page 3 of 11 Pages
<PAGE>


Item 4.  Purpose of Transaction.

     EIS acquired the Common Shares for investment purposes pursuant to the
terms of the Stock Purchase Agreement. Pursuant to the Stock Purchase Agreement,
(i) the Issuer granted EIS certain demand and piggyback registration rights
relating to the Common Shares; (ii) EIS agreed that it will not, nor will it
permit any of its affiliates to, purchase or otherwise acquire, directly or
indirectly, any additional equity securities of the Issuer (or rights or options
to purchase such securities) after the closing under the Purchase Agreement
without the prior written consent of the Issuer's Board of Directors (provided,
however, that the standstill agreement shall not apply to any securities issued
with respect to the Common Shares pursuant to a stock split, stock dividend,
recapitalization or reclassification approved by a disinterested majority of the
Issuer's Board of Directors); and (iii) EIS agreed that, during a reasonable and
customary period of time specified by the Issuer and an underwriter of Common
Shares or other securities of the Issuer following the effective date of a
registration statement of the Issuer filed under the Securities Act of 1933, as
amended (which period shall not exceed 180 days), to the extent requested by the
Issuer and such underwriter, EIS shall not, nor will it permit any of its
affiliates to, directly or indirectly, sell, contract to sell (including,
without limitation, any short sale), grant any option to purchase or otherwise
transfer or dispose of any securities of the Issuer held by any of them during
such period.

     Under a Letter Agreement dated as of November 10, 1998 (the "Letter
Agreement"), so long as EIS and its affiliates continue to own at least 5% of
the outstanding Common Shares, EIS shall be entitled to appoint one
representative to the Issuer's Board of Directors. Other than as set forth
above, neither Elan or EIS has any present plans or intentions which would
result in or relate to any of the transactions described in subparagraphs (a)
through (j) of Item 4 of Schedule 13D.

     The foregoing descriptions of the Stock Purchase Agreement and the Letter
Agreement do not purport to be complete and are qualified in their entirety by
reference to the full text of the Stock Purchase Agreement and the Letter
Agreement, copies of which are filed herewith as Exhibit 1 and Exhibit II and
are incorporated herein by reference.

Item 5.  Interest in Securities of the Issuer.

     (a) By virtue of the Stock Purchase Agreement, EIS is the beneficial owner
of 2,000,000 Common Shares, or approximately 6.0%, of the Issuer's common stock
(based upon outstanding Common Shares as of June 30, 1998). To the best
knowledge of EIS, no other person named in Item 2 above beneficially owns any of
the Issuer's Common Shares.


                               Page 4 of 11 Pages
<PAGE>

     (b) EIS has sole power to vote and sole authority to dispose or direct the
disposition of the entire amount of Common Shares reported by this Schedule 13D.

     (c) See the description of the Stock Purchase Agreement in Items 3 and 4
above.

     (d) N/A

     (e) N/A

Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
        Securities of the Issuer.

     The Stock Purchase Agreement and the Letter Agreement discussed in Item 4
above.

Item 7.  Items to be Filed as Exhibits.

Exhibit 1 Stock Purchase Agreement, dated as of July 22, 1998, between EIS and
          the Issuer.

Exhibit 2 Letter Agreement, dated as of November 10, 1998, between EIS and the
          Issuer.


                               Page 5 of 11 Pages
<PAGE>



                                    Signature


     The undersigned certifies that, after reasonable inquiry and to the best of
its knowledge and belief, the information set forth in this statement is true,
complete and correct.

November 10, 1998

                                 ELAN INTERNATIONAL SERVICES LTD.


                                 By: /s/ Kevin Insley
                                     ---------------------------------------
                                     Name: Kevin Insley
                                     Title: President and Chief Financial
                                              Officer







                               Page 6 of 11 Pages
<PAGE>


                                   Schedule A

     The (a) name, (b) business address, (c) principal occupation or employment
and the organization in which such occupation or employment is conducted and (d)
citizenship of each director (other than Messrs. Armen, Balog, Boushel, Crowley,
Gillespie, McIntyre, McLaughlin, Selkoe and Thornburgh) and officer of Elan
Corporation, plc ("Elan") are set forth in the following table:

1.  (a)      Donal J. Geaney
    (b)      Lincoln House, Lincoln Place, Dublin 2, Ireland
    (c)      Director, Chairman of the Board and Chief Executive Officer of Elan
    (d)      Ireland

2.  (a)      John Groom
    (b)      Lincoln House, Lincoln Place, Dublin 2, Ireland
    (c)      Director, President and Chief Operating Officer of Elan
    (d)      United Kingdom

3.  (a)      Thomas G. Lynch
    (b)      Lincoln House, Lincoln Place, Dublin 2, Ireland
    (c)      Director, Executive Vice President and Chief Financial
             Officer of Elan
    (d)      United Kingdom

4.  (a)      William F. Daniel
    (b)      Lincoln House, Lincoln Place, Dublin 2, Ireland
    (c)      Group Vice President, Finance and Group Controller of Elan
    (d)      Ireland

5.  (a)      Lisabeth F. Murphy
    (b)      800 Gateway Boulevard, South San Francisco, CA 94080
    (c)      Vice President and General Counsel of Elan
    (d)      United States

6.  (a)      Mark A. Pearson
    (b)      Lincoln House, Lincoln Place, Dublin 2, Ireland
    (c)      Partner, McCann FitzGerald; Secretary of Elan
    (d)      Ireland

     The (a) name, (b) business address, (c) principal occupation or employment
and the organization in which such occupation or employment is conducted and (d)
citizenship of each director (other than Messrs. Geaney, Groom, and Lynch) are
set forth in the following table:

1. (a)      Garo H. Armen, Ph.D.
   (b)      630 Fifth Avenue, Suite 2167, New York, New York  10111


                               Page 7 of 11 Pages
<PAGE>

   (c)      Managing General Partner, Armen Partners, L.P.; Chairman of the 
            Board and Chief Executive Officer of Antigenics, LLC
   (d)      United States

2. (a)      James Balog
   (b)      c/o Elan Corporation, plc, Lincoln House, Lincoln Place,
            Dublin 2, Ireland
   (c)      Retired
   (d)      United States

3. (a)      Brendan E. Boushel
   (b)      9 Upper Mount Street, Dublin 2, Ireland
   (c)      Retired
   (d)      Ireland

4. (a)      Laurence G. Crowley
   (b)      c/o Elan Corporation, plc, Lincoln House, Lincoln Place,
            Dublin 2, Ireland
   (c)      Executive Chairman, Michael Smurfit Graduate School of Business 
            of University College Dublin
   (d)      Ireland

5. (a)      Alan R. Gillespie, Ph.D.
   (b)      c/o Elan Corporation, plc, Lincoln House, Lincoln Place,
            Dublin 2, Ireland
   (c)      Managing Director, Goldman Sachs International
   (d)      United Kingdom

6. (a)      Kevin McIntyre, M.D.
   (b)      c/o Elan Corporation, plc, Lincoln House, Lincoln Place,
            Dublin 2, Ireland
   (c)      Associate Clinical Professor of Medicine at Harvard Medical School
   (d)      United States

7. (a)      Kyran McLaughlin
   (b)      Davy House, 49 Dawson Street, Dublin 2, Ireland
   (c)      Joint Chief Executive, Davy Stockbrokers
   (d)      Ireland

8. (a)      Dennis J. Selkoe, M.D.
   (b)      c/o Elan Corporation, plc, Lincoln House, Lincoln Place,
            Dublin 2, Ireland
   (c)      Professor of Neurology and Neuroscience at Harvard Medical
            School
   (d)      United States


                               Page 8 of 11 Pages
<PAGE>

9. (a)      Richard L. Thornburgh
   (b)      c/o Elan Corporation, plc, Lincoln House, Lincoln Place,
            Dublin 2, Ireland
   (c)      Counsel to the law firm of Kirkpatrick & Lockhart LLP
   (d)      United States






                               Page 9 of 11 Pages
<PAGE>


                                   Schedule B

     The (a) name, (b) business address, (c) principal occupation or employment
and the organization in which such occupation or employment is conducted and (d)
citizenship of each director and officer of Elan International Services Ltd.
("EIS") is set forth in the following table.

1. (a)      Kevin Insley
   (b)      102 St. James Court, Flatts Smiths, FL04 Bermuda
   (c)      Director, President and Chief Financial Officer of EIS
   (d)      United Kingdom

2. (a)      David J. Doyle
   (b)      Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda
   (c)      Director and Vice President of EIS; Attorney, Conyers Dill & Pearman
   (d)      United Kingdom

3. (a)      Thomas G. Lynch
   (b)      Lincoln House, Lincoln Place, Dublin 2, Ireland
   (c)      Chairman of the Board of Directors of EIS; Director, Executive
            Vice President and Chief Financial Officer of Elan
   (d)      United Kingdom

4. (a)      I.S. Outerbridge
   (b)      Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda
   (c)      Secretary of EIS; Corporate Manager, Codan Services Limited
   (d)      United Kingdom

5. (a)      James M. Macdonald
   (b)      Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda
   (c)      Director of EIS; Attorney, Conyers Dill & Pearman
   (d)      United Kingdom



                              Page 10 of 11 Pages
<PAGE>


                                  Exhibit Index

Exhibit No.                      Exhibit

     1    Stock Purchase Agreement, dated as of July 22, 1998, between Elan
          International Services Ltd. and Cytel Corporation.

     2    Letter Agreement, dated as of November 10, 1998, between Elan
          International Services Ltd. and Cytel Corporation.






                              Page 11 of 11 Pages


                            STOCK PURCHASE AGREEMENT


     THIS STOCK PURCHASE AGREEMENT (the "Agreement") is made as of July 22, 1998
(the "Effective Date") by and between CYTEL CORPORATION, a Delaware corporation
("Cytel"), and ELAN INTERNATIONAL SERVICES LTD., a Bermuda corporation and a
wholly-owned subsidiary of Elan Corporation, plc ("Elan").

                                    RECITALS

     WHEREAS, Cytel and Elan have entered into that certain Sublicense and
Option Agreement of even date herewith (the "Sublicense Agreement; and

     WHEREAS, in connection with, and as a condition of Cytel entering into, the
Sublicense Agreement, Elan agrees to purchase from Cytel shares of Cytel's
Common Stock on the terms and subject to the conditions set forth in this
Agreement.

     NOW, THEREFORE, in consideration of the foregoing recitals and the mutual
covenants and agreements contained herein, the parties hereto, intending to be
legally bound, do hereby agree as follows:

                                    AGREEMENT

1.  DEFINITIONS

     Capitalized terms used but not otherwise defined herein shall have the
meanings given such terms in the Sublicense Agreement.

2.  PURCHASE AND SALE OF SHARES

     Subject to the terms and conditions hereof, at the Closing (as defined
below), Elan shall purchase from Cytel, and Cytel shall issue and sell to Elan,
2,000,000 shares of Cytel's Common Stock, par value $0.01 per share (the
"Shares"), at a purchase price equal to $2.00 per share.

3.  CLOSING DATE; DELIVERY

     3.1 Closing. Subject to the terms of Sections 6 and 7, the closing of the
sale and purchase of the Shares under this Agreement (the "Closing") shall be
held at 10:00 a.m. (Pacific Time) on the Effective Date, at the offices of

<PAGE>
                                      -2-


Cytel, 3525 John Hopkins Court, San Diego, California, or at such time and place
as Cytel and Elan may agree.

     3.2 Delivery. At the Closing, subject to the terms and conditions hereof,
Cytel shall deliver to Elan a stock certificate, registered in the name of Elan,
representing the Shares dated as of the Closing against payment of the purchase
price therefor by wire transfer, unless other means of payment shall have been
agreed upon by Cytel and Elan.

4.  REPRESENTATIONS AND WARRANTIES OF CYTEL

     Cytel hereby makes the following representations and warranties to Elan,
except as set forth in the Schedule of Exceptions attached hereto as Exhibit A:

     4.1 Organization, Good Standing and Qualification. Cytel is a corporation
duly organized, validly existing and in good standing under the laws of the
State of Delaware and has all requisite corporate power and authority to carry
on its business. Cytel is duly qualified to transact business and is in good
standing in each jurisdiction in which the failure so to qualify would have a
material adverse effect on its business or properties.

     4.2 Authorization; Due Execution. Cytel has the requisite corporate power
and authority to enter into this Agreement and to perform its obligations under
the terms of this Agreement and, at the Closing will have the requisite
corporate power to sell the Shares. All corporate action on the part of Cytel,
its officers, directors and stockholders necessary for the authorization,
execution and delivery of this Agreement have been taken. This Agreement has
been duly authorized, executed and delivered by Cytel, and, upon due execution
and delivery by Elan, this Agreement will be a valid and binding agreement of
Cytel, enforceable in accordance with its terms, except as enforceability may be
limited by bankruptcy, insolvency, reorganization, moratorium or similar laws
affecting creditors' rights generally or by equitable principles.

     4.3 Capitalization. The authorized capital stock of Cytel consists of
75,000,000 shares of Common Stock, par value $0.01, and 10,000,000 shares of
Preferred Stock, par value $0.01. As of June 30, 1998, there were 32,870,387
shares of Common Stock and 659,898 shares of Series B Preferred Stock issued and
outstanding.


<PAGE>
                                      -3-


     4.4 Valid Issuance of Shares. The Shares, upon the Closing, when issued,
sold and delivered in accordance with the terms hereof for the consideration set
forth herein, will be duly and validly authorized and issued, fully paid and
nonassessable and, based in part upon the representations of Elan in this
Agreement, will be issued in compliance with all applicable federal and state
securities laws.

     4.5 Governmental Consents. No consent, approval, order or authorization of,
or registration, qualification, designation, declaration or filing with, any
federal, state, local or provincial governmental authority on the part of Cytel
is required in connection with the consummation of the transactions contemplated
by this Agreement, except for notices required or permitted to be filed with
certain state and federal securities commissions after the Closing which notices
will be filed on a timely basis.

     4.6 SEC Filings. Cytel has timely filed all reports, registration
statements and other documents required to be filed by it (the "SEC Filings")
under the Securities Act of 1933, as amended, and the rules and regulations
promulgated thereunder (the "Securities Act"), and the Securities Exchange Act
of 1934, as amended, and the rules and regulations promulgated thereunder (the
"Exchange Act"). The SEC Filings were prepared in accordance and complied in all
material respects with the applicable requirements of the Securities Act or the
Exchange Act, as the case may be. None of such forms, reports and statements,
including, without limitation, any financial statements, exhibits and schedules
included therein and documents incorporated therein by reference, at the time
filed, declared effective or mailed, as the case may be, contained an untrue
statement of a material fact or omitted to state a material fact required to be
stated therein or necessary in order to make the statements therein, in light of
the circumstances under which they were made, not misleading. Except to the
extent information contained in any of the SEC Filings has been revised,
corrected or superseded by a later filing of any such form, report or document
filed prior to the Effective Date, none of the SEC Filings contains an untrue
statement of a material fact or omits to state a material fact required to be
stated therein or necessary in order to make the statements therein, in light of
the circumstances under which they were made, not misleading.

     4.7 No Conflict. The execution, delivery and performance by Cytel of this
Agreement do not violate any provision of Cytel's Certificate of Incorporation
or Bylaws, any provision 


<PAGE>
                                      -4-


of any contract, arrangement or agreement, order, writ, judgment, injunction,
decree, determination or award to which Cytel is a party or by which it is
bound, or, to Cytel's knowledge, any law, rule or regulation (including, without
limitation, the rules and regulations of the Securities and Exchange Commission
(the "SEC") or any regulatory commission of any jurisdiction) currently in
effect having applicability to Cytel.

     4.8 Absence of Litigation. Except as disclosed in the SEC Filings, there is
no action, suit, proceeding or investigation (including any such matter related
to Cytel's intellectual property) pending or currently threatened against Cytel
or its properties before any court or governmental agency, which would have a
material adverse effect on Cytel's business, operations or assets, taken as a
whole (nor, to the best of Cytel's knowledge, is there any basis therefor).
There is no action, suit, proceeding or investigation which Cytel currently
intends to initiate.

     4.9 Confidentiality. Cytel hereby represents, warrants and covenants that
it shall maintain in confidence, and shall not use or disclose without prior
written consent of Elan, the terms of this Agreement and any information
identified in writing as confidential that is furnished to it by Elan in
connection with this Agreement. This obligation of confidentiality shall not
apply, however, to any information (a) in the public domain through no
unauthorized act or failure to act by Cytel, (b) lawfully disclosed to Cytel by
a third party who possessed such information without any obligation of
confidentiality, (c) lawfully developed by Cytel independent of any disclosure
by Cytel as supported by Elan's written records, or (d) required, upon the
advice of counsel to Cytel and after consultation with Elan, to be disclosed
under the rules and regulations of the SEC. Cytel further covenants that it
shall return to Elan all tangible materials containing such information upon
request by Elan.

5.  REPRESENTATIONS AND WARRANTIES OF ELAN

     Elan hereby makes the following representations and warranties to Cytel as
of the Effective Date and the Closing:

     5.1 Authorization; Due Execution. Elan has the requisite corporate power
and authority to enter into this Agreement and to perform its obligations under
the terms of this Agreement and, at the Closing, will have the requisite
corporate power to purchase the Shares. All corporate action on the part of
Elan, its officers, directors and stockholders necessary for 


<PAGE>
                                      -5-


the authorization, execution and delivery of this Agreement have been taken.
This Agreement has been duly authorized, executed and delivered by Elan, and,
upon due execution and delivery by Cytel, this Agreement will be a valid and
binding agreement of Elan, enforceable in accordance with its terms, except as
enforceability may be limited by bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting creditors' rights generally or by equitable
principles.

     5.2 Purchase Entirely for Own Account. This Agreement is made with Elan in
reliance upon Elan's representation to Cytel, which by Elan's execution of this
Agreement confirms, that the Shares to be purchased by Elan will be acquired for
investment for Elan's own account, not as a nominee or agent, and not with a
view to the resale or distribution of any part thereof, and that Elan has no
present intention of selling, granting any participation in, or otherwise
distributing the same. By executing this Agreement, Elan further represents that
Elan does not have any contract, undertaking, agreement or arrangement with any
person to sell, transfer or grant participation to such person or to any third
person, with respect to any of the Shares.

     5.3 Disclosure of Information. Elan has received all the information that
it has requested and that it considers necessary or appropriate for deciding
whether to enter into this Agreement and to purchase the Shares. Elan further
represents that it has had an opportunity to ask questions and receive answers
from Cytel regarding the terms and conditions of the offering of the Shares.

     5.4 Investment Experience. Elan is an investor in securities of companies
in the development stage and acknowledges that it is able to fend for itself,
can bear the economic risk of its investment and has such knowledge and
experience in financial or business matters that it is capable of evaluating the
merits and risks of the investment in the Shares. Elan also represents it has
not been organized solely for the purpose of acquiring the Shares.

     5.5 Accredited Investor. Elan is an "accredited investor" as such term is
defined in Rule 501 of the General Rules and Regulations prescribed by the SEC
pursuant to the Securities Act.

     5.6 Restricted Securities. Elan understands that (a) the Shares have not
been registered under the Securities Act by reason of a specific exemption
therefrom, that such securities 


<PAGE>
                                      -6-


must be held by it indefinitely and that Elan must, therefore, bear the economic
risk of such investment indefinitely, unless a subsequent disposition thereof is
registered under the Securities Act or is exempt from such registration; (b)
each certificate representing the Shares will be endorsed with the following
legends:

          (i) THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
     OF 1933, AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
     HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO
     THE SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL REASONABLY
     SATISFACTORY TO CYTEL THAT SUCH REGISTRATION IS NOT REQUIRED.

          (ii) Any legend required to be placed thereon by Cytel's Bylaws or
     under applicable state securities laws;

and (c) Cytel will instruct any transfer agent not to register the transfer of
the Shares (or any portion thereof) unless the conditions specified in the
foregoing legends are satisfied, until such time as a transfer is made, pursuant
to the terms of this Agreement, and in compliance with Rule 144 or pursuant to a
registration statement or, if the opinion of counsel referred to above is to the
further effect that such legend is not required in order to establish compliance
with any provisions of the Securities Act or this Agreement.

     5.7 Confidentiality. Elan hereby represents, warrants and covenants that it
shall maintain in confidence, and shall not use or disclose without prior
written consent of Cytel, the terms of this Agreement and any information
identified in writing as confidential that is furnished to it by Cytel in
connection with this Agreement. This obligation of confidentiality shall not
apply, however, to any information (a) in the public domain through no
unauthorized act or failure to act by Elan, (b) lawfully disclosed to Elan by a
third party who possessed such information without any obligation of
confidentiality, (c) lawfully developed by Elan independent of any disclosure by
Cytel as supported by Elan's written records, or (d) required to be disclosed
pursuant to an order or requirement of a court, administrative agency or other
government body (including the securities laws of any applicable jurisdiction).
Elan further covenants that it shall return to Cytel all tangible materials
containing such information upon request by Cytel.


<PAGE>
                                      -7-


6.  CONDITIONS OF ELAN's OBLIGATIONS

     The obligations of Elan under Section 2 of this Agreement to purchase the
Shares at the Closing are subject to the fulfillment on or before the Closing of
each of the following conditions, any of which may be waived by Elan:

     6.1 Representations and Warranties. The representations and warranties of
Cytel contained in Section 4 shall be true and correct in all material respects
on and as of the Closing.

     6.2 Performance. Cytel shall have performed and complied with all
agreements, obligations and conditions in this Agreement, if any, that are
required to be performed or complied with by it on or before the Closing.

     6.3 Compliance Certificate. The President or a Vice President of Cytel
shall have delivered to Elan at the Closing a certificate certifying that the
conditions specified in Sections 6.1 and 6.2 have been fulfilled.

     6.4 Proceedings and Documents. All corporate and other proceedings in
connection with the transactions contemplated at the Closing and all documents
incident thereto shall be reasonably satisfactory in form and substance to Elan,
and it shall have received all such counterpart original and certified or other
copies of such documents as it may reasonably request.

     6.5 Sublicense. The Sublicense Agreement is a valid and enforceable
agreement and is in full force and effect.

7.  CONDITIONS OF CYTEL'S OBLIGATIONS

     The obligations of Cytel to Elan under this Agreement are subject to the
fulfillment on or before the Closing of each of the following conditions by
Elan, any of which may be waived by Cytel: 

     7.1 Representations and Warranties. The representations and warranties of
Elan contained in Section 5 hereof shall be true and correct in all material
respects on and as of the Closing.

     7.2 Performance. Elan shall have performed and complied with all
agreements, obligations and conditions in this Agreement, if any, that are
required to be performed or complied with by it on or before the Closing.


<PAGE>
                                      -8-


     7.3 Compliance Certificate. The President or other duly authorized officer
of Elan shall have delivered to Cytel at the Closing a certificate certifying
that the conditions specified in Sections 7.1 and 7.2 have been fulfilled.

     7.4 Payment of Purchase Price. Elan shall have tendered delivery of the
purchase price for the Shares specified in Section 2 at the Closing.

     7.5 Proceedings and Documents. All corporate and other proceedings in
connection with the transactions contemplated at the Closing and all documents
incident thereto shall be reasonably satisfactory in form and substance to
Cytel, and it shall have received all such counterpart original and certified or
other copies of such documents as it may reasonably request.

8. REGISTRATION RIGHTS

     8.1 Certain Definitions. When used in this Section 8 of this Agreement, the
following terms shall have the following respective meanings:

          (a) "Form S-3" means Form S-3 under the Securities Act as in effect on
     the date of this Agreement, or any substantially similar, equivalent or
     successor form under the Securities Act.

          (b) "Holder" means Elan or any transferee of registration rights under
     Section 8.10 hereof who then holds any outstanding Registrable Securities.

          (c) "register," "registered" and "registration" refer to a
     registration effected by preparing and filing a registration statement in
     compliance with the Securities Act, and the declaration or ordering of the
     effectiveness of such registration statement.

          (d) "Registrable Securities" means (i) the Shares, and (ii) shares of
     Cytel Common Stock issued in respect of the Shares by reason of any stock
     split, stock dividend, recapitalization or similar event which have not
     been sold to the public in either case until such Shares are sold pursuant
     to an effective registration statement.

          (e) "Registration Expenses" means all expenses incurred by Cytel in
     complying with Sections 8.2, 8.3 and 8.4 hereof, including, without
     limitation, all registration, qualification and filing fees, printing
     expenses, 


<PAGE>
                                      -9-


     escrow fees, fees and disbursements of counsel, blue sky fees and expenses,
     and the expense of any special audits incident to or required by any such
     registration (but excluding the compensation of regular employees of Cytel
     which shall be paid in any event by Cytel).

          (f) "Selling Expenses" means all underwriting discounts and selling
     commissions applicable to the applicable sale.

     8.2 Demand Registration.

     (a) Subject to the conditions of this Section 8.2, if Cytel shall receive a
written request from the Holders of 50% or more of the Registrable Securities
then outstanding (the "Initiating Holders") that Cytel file a registration
statement under the Securities Act covering the registration of Registrable
Securities having an aggregate offering price to the public in excess of
$2,000,000 (a "Qualified Public Offering"), then Cytel shall, within 30 days of
the receipt thereof, give written notice of such request to all Holders, and
subject to the limitations of this Section 8.2, use its best efforts to effect,
as soon as practicable but in no event later than 60 days of the receipt of the
request, the registration under the Securities Act of all Registrable Securities
that the Holders request to be registered.

     (b) If the Initiating Holders intend to distribute the Registrable
Securities covered by their request by means of an underwriting, they shall so
advise Cytel as a part of their request made pursuant to this Section 8.2 and
Cytel shall include such information in the written notice referred to in
Section 8.2(a). In such event, the right of any Holder to include its
Registrable Securities in such registration shall be conditioned upon such
Holder's participation in such underwriting and the inclusion of such Holder's
Registrable Securities in the underwriting (unless otherwise mutually agreed by
a majority in interest of the Initiating Holders and such Holder) to the extent
provided herein. All Holders proposing to distribute their securities through
such underwriting shall enter into an underwriting agreement in customary form
with the underwriter or underwriters selected for such underwriting by a
majority in interest of the Initiating Holders (which underwriter or
underwriters shall be reasonably acceptable to Cytel). Holders shall have no
obligation to make any representations or warranties other than with respect to
their ownership of Shares. Holders shall have no indemnification obligations
other than with respect to information about such Holders 


<PAGE>
                                      -10-


provided in writing by such Holders for inclusion in the registration statement.
Notwithstanding any other provision of this Section 8.2, if the underwriter
advises Cytel that marketing factors require a limitation of the number of
securities to be underwritten (including Registrable Securities) then Cytel
shall so advise all Holders of Registrable Securities which would otherwise be
underwritten pursuant hereto, and the number of shares that may be included in
the underwriting shall be allocated to the Holders of such Registrable
Securities on a pro rata basis based on the number of Registrable Securities
held by all such Holders (including the Initiating Holders). Any Registrable
Securities excluded or withdrawn from such underwriting shall be withdrawn from
the registration.

     (c) Cytel shall not be required to effect a registration pursuant to this
Section 8.2:

          (i) prior to the first anniversary of the date of this Agreement; or

          (ii) after Cytel has effected one registration pursuant to this
     Section 8.2, and such registrations have been declared or ordered effective
     and has complied with the other obligations of Cytel under this Agreement;
     or

          (iii) if Cytel shall furnish to the requesting Holders a certificate
     signed by the President of Cytel stating that in the good faith judgment of
     the Board of Directors of Cytel it would be seriously detrimental to Cytel
     or its stockholders for the registration statement to be filed at the date
     filing would be required, in which case Cytel shall have an additional
     period of not more than 120 days within which to file such registration
     statement; provided, however, that Cytel shall not use this right more than
     once in any 12 month period.

     8.3 Company Registration.

     (a) If, at any time or from time to time, Cytel shall determine to register
any of its securities, either for its own account or the account of a security
holder or holders exercising their respective demand registration rights, other
than a registration relating solely to employee benefit plans on Form S-8 or
similar forms which may be promulgated in the future or a registration on Form
S-4 or similar forms which may be promulgated in the future relating solely to a
SEC Rule 145 or similar transaction, Cytel will (i) promptly give to each Holder
written notice thereof and (ii) include in such regis-


<PAGE>
                                      -11-


tration (and any related qualification under Blue Sky laws or other compliance),
and in any underwriting involved therein, all Registrable Securities of such
Holders as specified in a written request or requests made within 15 days after
receipt of such written notice from Cytel.

     (b) If the registration of which Cytel gives notice is for a registered
public offering involving an underwriting, Cytel shall so indicate in the notice
given pursuant to Section 8.3(a). In such event the right of any Holder to
registration pursuant to this Section 8.3 shall be conditioned upon such
Holder's agreeing to participate in such underwriting and in the inclusion of
such Holder's Registrable Securities in the underwriting to the extent provided
herein. All Holders proposing to distribute their securities through such
underwriting shall (together with Cytel and the other holders distributing their
securities through such underwriting) enter into an underwriting agreement in
customary form with the underwriter or underwriters selected for such
underwriting by Cytel or by other holders exercising any demand registration
rights. Holders shall have no obligation to make any representations or
warranties other than with respect to their ownership of Shares. Holders shall
have no indemnification obligations other than with respect to information about
such Holders provided in writing by such Holders for inclusion in the
registration statement. If any Holder disapproves of the terms of any such
underwriting, such Holder may elect to withdraw therefrom by written notice to
Cytel and the underwriter. Any securities excluded or withdrawn from such
underwriting shall be withdrawn from such registration. Notwithstanding any
other provision of this Section 8.3, if the underwriter determines that
marketing factors require a limitation of the number of shares to be
underwritten, the underwriter may exclude some or all of the shares of
Registrable Securities from such registration and underwriting.

     8.4 Form S-3 Registration. Each Holder shall have the right to request
registrations on Form S-3 (such requests shall be in writing and shall state the
number of shares of Registrable Securities to be disposed of and the intended
method of disposition of such shares by each such Holder), subject only to the
following limitations:

          (a) Cytel shall not be obligated to cause a registration on Form S-3
     to become effective prior to 180 days following the effective date of a
     Cytel-initiated registration (other than a registration effected solely to

<PAGE>
                                      -12-


     qualify an employee benefit plan or to effect a business combination
     pursuant to Rule 145);

          (b) Cytel shall not be required to effect a registration pursuant to
     this Section 8.4 unless the Holder or Holders requesting such a
     registration propose to dispose of shares of Registrable Securities having
     an aggregate disposition price (before deduction of underwriting discounts
     and expenses of sale) of at least $1,000,000;

          (c) Cytel shall not be required to effect a registration pursuant to
     this Section 8.4 if Cytel shall furnish to the requesting Holders a
     certificate signed by the President of Cytel stating that in the good faith
     judgment of the Board of Directors of Cytel it would be seriously
     detrimental to Cytel or its stockholders for the registration statement to
     be filed at the date filing would be required, in which case Cytel shall
     have an additional period of not more than 120 days within which to file
     such registration statement; provided, however, that Cytel shall not use
     this right more than once in any 12 consecutive month period; and

          (d) Cytel shall not be required to effect a registration pursuant to
     this Section 8.4 more often than once in any 12 consecutive month period.

     Cytel shall give notice to all Holders of the receipt of a request for
registration pursuant to this Section 8.4 and shall use its best efforts to
cause all Registrable Securities that such Holders have requested, within 15
days after receipt of such written notice, be registered in accordance with this
Section 8.4 to be registered under the Securities Act. Subject to the foregoing,
Cytel will use its best efforts to effect promptly any registration pursuant to
this Section 8.4.

     8.5 Expenses of Registration. All Registration Expenses incurred in
connection with any registration, qualification or compliance pursuant to
Sections 8.2, 8.3 and 8.4 (exclusive of Selling Expenses but inclusive of the
reasonable fees and expenses of any special counsel to the selling Holders)
shall be borne by Cytel. All Selling Expenses incurred in connection with any
registrations hereunder shall be borne by the holders of the securities
registered pro rata on the basis of the number of shares registered.

     8.6 Registration Procedures. In the case of each registration,
qualification or compliance effected by Cytel pursuant 


<PAGE>
                                      -13-


to this Section 8, Cytel will keep each Holder advised in writing as to the
initiation of each registration, qualification and compliance and as to the
completion thereof. At its expense Cytel will:

          (a) Keep such registration, qualification or compliance effective for
     a period of 120 days or until the Holder or Holders have completed the
     distribution described in the registration statement relating thereto,
     whichever first occurs;

          (b) Prepare and file with the SEC such amendments and supplements to
     such registration statement and the prospectus used in connection with such
     registration statement as may be necessary to comply with the provisions of
     the Securities Act with respect to the disposition of all securities
     covered by such registration statement;

          (c) Furnish to the Holders such numbers of copies of a prospectus,
     including a preliminary prospectus, in conformity with the requirements of
     the Securities Act, and such other documents as they may reasonably request
     in order to facilitate the disposition of Registrable Securities owned by
     them;

          (d) Use its reasonable efforts to register and qualify the securities
     covered by such registration statement under such other securities or Blue
     Sky laws of such jurisdictions as shall be reasonably requested by the
     Holders, provided that Cytel shall not be required in connection therewith
     or as a condition thereto to qualify to do business or to file a general
     consent to service of process in any such states or jurisdictions;

          (e) Subject to Sections 8.2(b) and 8.3(b), in the event of any
     underwritten public offering, enter into and perform its obligations under
     an underwriting agreement, in usual and customary form, with the managing
     underwriter of such offering. Each Holder participating in such
     underwriting shall also enter into and perform its obligations under such
     an agreement; and

          (f) Notify each Holder of Registrable Securities covered by such
     registration statement at any time when a prospectus relating thereto is
     required to be delivered under the Securities Act of the happening of any
     event as a result of which the prospectus included in such regis-


<PAGE>
                                      -14-


     tration statement, as then in effect, includes an untrue statement of a
     material fact or omits to state a material fact required to be stated
     therein or necessary to make the statements therein not misleading in the
     light of the circumstances then existing.

     8.7 Indemnification. In the event any Registrable Securities are included
in a registration statement under Section 8.2, 8.3 and 8.4:

          (a) To the extent permitted by law, Cytel will indemnify each Holder,
     each of its officers, directors, employees and partners, and each person
     controlling such Holder within the meaning of Section 15 of the Securities
     Act, with respect to which registration, qualification or compliance has
     been effected pursuant to this Section 8, and each underwriter, if any, and
     each person who controls any underwriter within the meaning of Section 15
     of the Securities Act, against all expenses, claims, losses, damages and
     liabilities (or actions in respect thereof), including any of the foregoing
     incurred in settlement of any litigation, commenced or threatened, arising
     out of or based on any untrue statement (or alleged untrue statement) of a
     material fact contained in any registration statement, prospectus, offering
     circular or other document, or any amendment or supplement thereto,
     incident to any such registration, qualification or compliance, or based on
     any omission (or alleged omission) to state therein a material fact
     required to be stated therein or necessary to make the statements therein,
     in light of the circumstances in which they were made, not misleading, or
     any violation by Cytel of any rule or regulation promulgated under the
     Securities Act applicable to Cytel and relating to action or inaction
     required of Cytel in connection with any such registration, qualification
     or compliance, and will reimburse each such Holder, each of its officers
     and directors and partners, and each person controlling such Holder, each
     such underwriter and each person who controls any such underwriter, for any
     legal and any other expenses reasonably incurred in connection with
     investigating, preparing or defending any such claim, loss, damage,
     liability or action; provided however, that the indemnity agreement set
     forth in this Section 8.7(a) shall not apply to amounts paid in settlement
     of any such claim, loss, damage, liability or action if such settlement is
     effected without the consent of Cytel, which consent shall not be
     unreasonably withheld; provided further, that Cytel will not be liable in
     any such case to the ex-


<PAGE>
                                      -15-


     tent that any such claim, loss, damage, liability or expense arises out of
     or is based on any untrue statement or omission or alleged untrue statement
     or omission, made in reliance upon and in conformity with written
     information furnished to Cytel by an instrument duly executed by such
     Holder or underwriter and stated to be specifically for use therein.

          (b) To the extent permitted by law, each Holder will, if Registrable
     Securities held by such Holder are included in the securities as to which
     such registration, qualification or compliance is being effected, indemnify
     Cytel, each of its directors, officers and employees, each underwriter, if
     any, of Cytel's securities covered by such a registration statement, each
     person who controls Cytel or such underwriter within the meaning of Section
     15 of the Securities Act, and each other such Holder, each of its officers,
     directors, employees and partners and each person controlling such Holder
     within the meaning of Section 15 of the Securities Act, against all
     expenses, claims, losses, damages and liabilities (or actions in respect
     thereof) including any of the foregoing incurred in settlement of any
     litigation commenced or threatened, arising out of or based on any untrue
     statement (or alleged untrue statement) of a material fact contained in any
     such registration statement, prospectus, offering circular or other
     document, or any amendment or supplement thereto, incident to any such
     registration, qualification or compliance or based on any omission (or
     alleged omission) to state therein a material fact required to be stated
     therein or necessary to make the statements therein, in the light of the
     circumstances in which they were made, not misleading, or any violation by
     Cytel of any rule or regulation promulgated under the Securities Act
     applicable to Cytel in connection with any such registration,
     qualification, or compliance, and will reimburse Cytel, such Holders, such
     directors, officers, partners, persons, underwriters or control persons for
     any legal or any other expenses reasonably incurred in connection with
     investigation, preparing or defending any such claim, loss, damage,
     liability or action, in each case to the extent, but only to the extent,
     that such untrue statement (or alleged untrue statement) or omission (or
     alleged omission) is made in such registration statement, prospectus,
     offering circular or other document or any amendment or supplement thereto
     in reliance upon and in conformity with written information furnished to
     Cytel by an instrument duly executed by such Holder and stated to be
     spe-


<PAGE>
                                      -16-


     cifically for use therein; provided, however, that the indemnity agreement
     set forth in this Section 8.7(b) shall not apply to amounts paid in
     settlement of any such claim, loss, damage, liability or action if such
     settlement is effected without the consent of the Holder, which consent
     shall not be unreasonably withheld; provided further, that the obligations
     of such Holders hereunder shall be limited to an amount equal to the
     proceeds to each such Holder of Registrable Securities sold as contemplated
     herein.

          (c) Each party entitled to indemnification under this Section 8.7 (the
     "Indemnified Party") shall give notice to the party required to provide
     indemnification (the "Indemnifying Party") promptly after such Indemnified
     Party has actual knowledge of any claim as to which indemnity may be
     sought, and shall permit the Indemnifying Party to assume the defense of
     any such claim or any litigation resulting therefrom, provided that counsel
     for the Indemnifying Party, who shall conduct the defense of such claim or
     litigation, shall be approved by the Indemnified Party (whose approval
     shall not be unreasonably withheld), and the Indemnified Party may
     participate in such defense at its own expense, and provided further that
     the failure of any Indemnified Party to give notice as provided herein
     shall not relieve the Indemnifying Party of its obligations under this
     Section 8.7 unless such failure resulted in actual detriment to the
     Indemnifying Party. No Indemnifying Party, in the defense of any such claim
     or litigation, shall, except with the consent of each Indemnified Party,
     consent to entry of any judgment or enter into any settlement which does
     not include as an unconditional term thereof the giving by the claimant or
     plaintiff to such Indemnified Party a release from all liability in respect
     of such claim or litigation.

          (d) If the indemnification provided for in this Section 8.7 is held by
     a court of competent jurisdiction to be unavailable to an Indemnified Party
     with respect to any loss, liability, claim, damage, or expense referred to
     therein, then the Indemnifying Party, in lieu of indemnifying such
     Indemnified Party hereunder, shall contribute to the amount paid or payable
     by such Indemnified Party as a result of such loss, liability, claim,
     damage, or expense in such proportion as is appropriate to reflect the
     relative fault of the Indemnifying Party on the one hand and of the
     Indemnified Party on the other in connection with the statements or
     omissions that resulted in such loss, liability, claim, damage or expense
     as well as any
<PAGE>
                                      -17-


     other relevant equitable considerations. The relative fault of the
     Indemnifying Party and of the Indemnified Party shall be determined by
     reference to, among other things, whether the untrue or alleged untrue
     statement of a material fact or the omission to state a material fact
     relates to information supplied by the Indemnifying Party or by the
     Indemnified Party and the parties' relative intent, knowledge, access to
     information, and opportunity to correct or prevent such statement or
     omission.

          (e) The obligations of Cytel and Holders under this Section 8.7 shall
     survive the completion of any offering of Registrable Securities in a
     registration statement under this Section 8 and otherwise.

     8.8 Information by Holder. The Holder or Holders of Registrable Securities
included in any registration shall furnish to Cytel such information as Cytel
may request in writing regarding such Holder or Holders and the distribution
proposed by such Holder or Holders and as shall be required in connection with
any registration, qualification or compliance referred to in this Section 8.

     8.9 Rule 144 Reporting. With a view to making available the benefits of
certain rules and regulations of the SEC which may at any time permit the sale
of the Registrable Securities to the public without registration, Cytel agrees
to:

          (a) Make and keep public information available, as those terms are
     understood and defined in Rule 144 under the Securities Act;

          (b) File with the SEC in a timely manner all reports and other
     documents required of Cytel under the Exchange Act; and

          (c) So long as a Holder owns any Registrable Securities, to furnish to
     such Holder upon request a written statement by Cytel as to its compliance
     with the reporting requirements of Rule 144 and of the Securities Act and
     the Exchange Act, a copy of the most recent annual or quarterly report of
     Cytel, and such other reports and documents of Cytel as a Holder may
     reasonably request in availing itself of any rule or regulation of the SEC
     allowing a Holder to sell any such securities without registration.


<PAGE>
                                      -18-


     8.10 Transfer of Registration Rights. The rights to cause Cytel to register
securities granted under Sections 8.2, 8.3 and 8.4 may be assigned or otherwise
conveyed to a transferee or assignee of Registrable Securities, who shall be
considered a "Holder" for purposes of this Section 8, provided that (a) Cytel is
given written notice by such Holder at the time of or within a reasonable time
(but not more than 30 days) after said transfer, stating the name and address of
said transferee or assignee and identifying the securities with respect to which
such registration rights are being assigned, and (b) the transferee acquires at
least 500,000 Shares in a private transaction.

     8.11 Termination of Registration Rights. The registration rights granted
pursuant to this Section 8 shall terminate (a) upon the third anniversary of the
Effective Date, or (b) as to any particular Holder, at such time as all
Registrable Securities held by such Holder can be sold without compliance with
the registration requirements of the Securities Act pursuant to Rule 144
(including Rule 144(k)) promulgated thereunder.

9.  COVENANTS

     9.1 Delivery of Financial Statements. So long as Elan holds the Shares
Cytel shall deliver to Elan copies of its Forms 10-K and 10-Q as filed with the
SEC.

     9.2 Standstill Agreement. Athena hereby covenants and agrees that it will
not, nor will it permit any of its affiliates (including parents, subsidiaries
or other related entities) to, purchase or otherwise acquire, directly or
indirectly, any additional equity securities of Cytel (or rights or options to
purchase such securities) after the Closing under this Agreement without the
prior written approval of Cytel's Board of Directors; provided, however, that
this clause shall not apply to any securities issued with respect to the Shares
pursuant to a stock split, stock dividend, recapitalization or reclassification
approved by a disinterested majority of the Company's Board of Directors.

     9.3 "Market Stand-Off" Agreement. Elan hereby agrees that during a
reasonable and customary period of time specified by Cytel and an underwriter of
Common Stock or other securities of Cytel following the effective date of a
Registration Statement of Cytel filed under the Securities Act (which period
shall not exceed 180 days), to the extent requested by Cytel and such
underwriter, it shall not, nor will it permit any of its affiliates (including
parents, subsidiaries or other re-


<PAGE>
                                      -19-


lated entities) to, directly or indirectly, sell, contract to sell (including,
without limitation, any short sale), grant any option to purchase or otherwise
transfer or dispose of any securities of Cytel held by any of them during such
period. In order to enforce the foregoing covenant, Cytel may impose
stop-transfer instructions with respect to the securities held by Elan and its
affiliates that are subject to the foregoing restriction until the end of such
period.

10.  MISCELLANEOUS

     10.1 Force Majeure. Neither party shall be held liable or responsible to
the other party nor be deemed to have defaulted under or breached this Agreement
for failure or delay in fulfilling or performing any term of this Agreement when
such failure or delay is caused by or results from causes beyond the reasonable
control of the affected party, including, without limitation, fire, floods,
earthquakes, natural disasters, embargoes, war, acts of war (whether war be
declared or not), insurrections, riots, civil commotions, strikes, lockouts or
other labor disturbances, acts of God or acts, omissions or delays in acting by
any governmental authority or the other party.

     10.2 Assignment. Except as expressly provided hereunder, neither this
Agreement nor any rights or obligations hereunder may be assigned or otherwise
transferred by either party without the prior written consent of the other party
(which consent shall not be unreasonably withheld)[; provided, however, that
either party may assign this Agreement and its rights and obligations hereunder
without the other party's consent (a) in connection with the transfer or sale of
all or substantially all of the business of such party to which this Agreement
and the Sublicense Agreement relate to another party, whether by merger, sale of
stock, sale of assets or otherwise, or (b) to any Affiliate. Notwithstanding the
foregoing, any such assignment to an Affiliate shall not relieve the assigning
party of its responsibilities for performance of its obligations under this
Agreement. The rights and obligations of the parties under this Agreement shall
be binding upon and inure to the benefit of the successors and permitted assigns
of the parties. Any assignment not in accordance with this Agreement shall be
void.

     10.3 Finder's Fee. Each party represents that it neither is nor will be
obligated for any finders' fee or commission in connection with this
transaction. Elan agrees to indemnify and hold harinless Cytel from any
liability for any 


<PAGE>
                                      -20-


commission or compensation in the nature of a finders' fee (and the costs and
expenses of defending against such liability or asserted liability) for which
Elan or any of its officers, employees or representatives is responsible. Cytel
agrees to indemnify and hold harmless Elan from any liability for any commission
or compensation in the nature of a finder's fee (and the costs and expenses of
defending against such liability or asserted liability) for which Cytel or any
of its officers, employees or representatives is responsible.

     10.4 Publicity. The parties agree that neither party shall originate any
press release or other public announcement, written or oral, or otherwise make
any disclosure relating to the existence or terms of or performance under this
Agreement without the prior written approval of the other party, except as may
otherwise be required by law.

     10.5 Severability. In case any provision of this Agreement shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions shall not in any way be affected or impaired thereby.

     10.6 Governing Law. This Agreement shall be governed by, and construed and
enforced in accordance with, the laws of the State of California, without regard
to its choice of law provisions.

     10.7 Notices. Any notices or communications provided for in this Agreement
to be made by either of the parties to the other shall be in English in writing
and delivered personally or sent by registered or certified mail, postage paid,
by overnight delivery service such as FedEx or UPS or by facsimile, with
confirmation of receipt, addressed as follows:

         If to Cytel:     CYTEL CORPORATION
                          3525 John Hopkins Court
                          San Diego, CA  92121
                          Attn: President
                          Facsimile:  (619) 552-8801

         If to Elan:      ELAN INTERNATIONAL SERVICE LTD.
                          102 St. James Court
                          Flatts Smiths, FL04 Bermuda
                          Attention:  President
                          Facsimile:  (441) 292-2224

         Copy to:         ATHENA NEUROSCIENCES, INC.
                          800 Gateway Blvd.

<PAGE>
                                      -21-


                          South San Francisco, CA  94080
                          Attention:  General Counsel
                          Facsimile:  (650) 875-3620

     Either party may by like notice specify or change an address to which
notices and communications shall thereafter be sent. Notices sent by facsimile
shall be effective upon confirmation of receipt, notices sent by mail or
overnight delivery service shall be effective upon receipt, and notices given
personally shall be effective when delivered.

     10.8 Entire Agreement; Amendment. This Agreement sets forth all of the
covenants, promises, agreements, warranties, representations, conditions and
understandings between the parties hereto with respect to the subject matter
hereof, and supersedes and terminates all prior agreements and understandings
between the parties with respect to the subject matter hereof. There are no
covenants, promises, agreements, warranties, representations, conditions or
understandings with respect to the subject matter hereof, either oral or
written, between the parties other than as set forth herein. No subsequent
alteration, amendment, change or addition to this Agreement shall be binding
upon the parties hereto unless reduced to writing and signed by the respective
authorized officers of the parties.

     10.9 Headings. The captions contained in this Agreement are not a part of
this Agreement, but are merely guides or labels to assist in locating and
reading the several Articles hereof.

     10.10 Waiver. Except as specifically provided for herein, the waiver from
time to time by either of the parties of any of their rights or their failure to
exercise any remedy shall not operate or be construed as a continuing waiver of
the same rights or remedies or of any other of such party's rights or remedies
provided in this Agreement.

     10.11 Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.




<PAGE>
                                      -22-


     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first set forth above.

CYTEL CORPORATION                          ELAN INTERNATIONAL SERVICES LTD.


By:  /s/Virgil Thompson                    By: /s/ Kevin Insley                 
     ----------------------------              ------------------------------

Name:  Virgil Thompson                     Name:  Kevin Insley             
     ----------------------------               -----------------------------
Title: President and CEO                   Title: President                  
     ----------------------------               -----------------------------



<PAGE>


                                    EXHIBIT A


                             SCHEDULE OF EXCEPTIONS


                                      None









                        ELAN INTERNATIONAL SERVICES LTD.
                               102 St. James Court
                           Flatt Smiths, FL04 Bermuda


CYTEL CORPORATION                                             November 10, 1998
9393 Towne Center Drive
San Diego, California   92121

Gentlemen:

     Reference is hereby made to the Sublicense and Option Agreement by and
between Cytel Corporation ("Cytel") and Elan International Services Ltd.
("Elan"), dated as of July 22, 1998, as amended and restated on November 10,
1998 (the "Agreement"). Capitalized terms used herein shall have the meanings
set forth in the Agreement.

     In connection with the Agreement, we have agreed that as of July 22, 1998
Elan is entitled to appoint one representative to Cytel's Board of Directors,
subject to certain conditions. Accordingly, in consideration of the mutual
agreements and representations contained herein and in the Agreement, we agree
that:

     (i) So long as Elan and its Affiliates continue to own at least 5% of the
outstanding shares of Cytel's Common Stock, Elan shall be entitled to appoint
one representative (which representative shall be approved by Cytel's Board of
Directors, such approval not to be unreasonably withheld) to Cytel's Board of
Directors, and, in connection therewith, Cytel shall give such representative
copies of all notices, minutes, consents and other materials, financial or
otherwise (including annual budgets and operating plans), which Cytel provides
to its Board of Directors.

     For purposes of this Letter, "Affiliate" means any corporation or other
entity which controls, is controlled by, or is under common control with, a
party. A corporation or other entity shall be regarded as in control of another
corporation or entity if it owns or directly or indirectly controls more than
50% of the voting securities or other ownership interest of the other
corporation or entity, or if it possesses, directly or indirectly, the power to
direct or cause the direction of the management and policies of the corporation
or other entity;


<PAGE>
                                      -2-


     (ii) except as herein specifically amended or supplemented, the Agreement
shall continue in full force in accordance with its terms; and

     (iii) the provisions of this letter shall be deemed by the parties to be
effective as of July 22, 1998, nunc pro tunc.

     Please acknowledge your agreement to the foregoing by executing this letter
in the space provided below.

                                Very truly yours,

                                ELAN INTERNATIONAL SERVICES LTD.



                                By: /s/ Kevin Insley 
                                   -----------------------------------
                                    Name:  Kevin Insley
                                    Title: President


Accepted and Agreed to as of the date first above written:

CYTEL CORPORATION



By:  /s/ Virgil Thompson
     ------------------------------
     Name:  Virgil Thompson
     Title: President and CEO




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