MEDTOX SCIENTIFIC INC
S-3/A, 2000-09-06
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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As filed  with the  Securities  and  Exchange  Commission  on September 6, 2000
                                                 Registration No. 333-44942
================================================================================


                UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                           PRE-EFFECTIVE AMENDMENT #1


                                    FORM S-3

             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                             MEDTOX SCIENTIFIC, INC.
                (Name of Registrant as specified in its Charter)

         Delaware                                          95-3863205
    (State or other Jurisdiction of                     (I.R.S. Employer
    Incorporation or Organization)                     Identification Number)

                             Medtox Scientific, Inc.
                             402 West County Road D
                            St. Paul, Minnesota 55112
                                 (651) 636-7466
(Address and Telephone Number of Registrant's Principal Executive Offices)
-------------------------------------------------------------------------------
                             James B. Lockhart, CFO
                             Medtox Scientific, Inc.
                             402 West County Road D
                            St. Paul, Minnesota 55112
                                 (651) 636-7466

            (Name, Address and Telephone Number of Agent for Service)

                                   Copies to:

                             Robert R. Ribeiro, Esq.
                            Julius M. Davidson, Esq.
                            Fredrikson & Byron, P.A.
                       900 Second Avenue South, Suite 1100
                          Minneapolis, Minnesota 55402
                                 (612) 347-7000

         Approximate  date of commencement of proposed sale to the public:  From
time  to time  after  the  effective  date of  this  Registration  Statement  as
determined by market  conditions  and other factors and as Selling  Shareholders
shall determine.

         If the only securities  being registered on this form are being offered
pursuant to dividend or interest  reinvestment plans, please check the following
box: [ ]

         If any of the securities being registered on this form to be offered on
a delayed or continuous basis,  pursuant to Rule 415 under the Securities Act of
1933, check the following box: [X]

         If this Form is filed to register additional  securities of an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering: [ ]

         If this  Form is a  post-effective  amendment  filed  pursuant  to Rule
462(c) under the  Securities  Act,  please check the  following box and list the
Securities  Act  registration   statement   number  of  the  earlier   effective
registration statement for the same offering: [ ]

         If delivery of the  prospectus  is expected to be made pursuant to Rule
434, please check the following box: [ ]
<TABLE>

                         CALCULATION OF REGISTRATION FEE
<CAPTION>

      Title of Each                                     Proposed Maximum          Proposed Maximum
      Class of Securities           Amount to be         Offering Price          Aggregate Offering           Amount of
      to be Registered              Registered             per Share (1)              Price (1)            Registration Fee
<S>                            <C>                      <C>                     <C>                     <C>

--------------------------- ------------------------ ------------------------ ------------------------- ----------------------
 Common Stock (par value          567,652 shares             $10.81                  $6,136,318              $1,620
     $0.15 per share)
--------------------------- ------------------------ ------------------------ ------------------------- ----------------------
 Common Stock (par value          649,230 shares             $12.50                  $8,115,375              $2,142
   $0.15 per share)
  underlying warrants
--------------------------- ------------------------ ------------------------ ------------------------- ----------------------
 Common Stock (par value          102,500 shares              $8.75                    $896,875                $237
  $0.15 per share)
  underlying options
--------------------------- ------------------------ ------------------------ ------------------------- ----------------------
          TOTAL                 1,319,382 shares                                    $15,148,568              $3,999
</TABLE>


(1)   Estimated  solely for the purpose of calculating the  registration fee in
      accordance with Rule 457(c) under the Securities Act of 1933, as amended.
      Registration fee of $3,999 was previously paid on August 31, 2000.
(2)   Together  with such number of  indeterminate  number of  securities  to be
      offered as a result of any judgment  from stock splits,  stock  dividends,
      exercise price adjustments or similar events.


The Registrant hereby amends this  Registration  Statement on such date or dates
as may be necessary to delay its effective date until the Registrant  shall file
a further amendment which specifically  states that this Registration  Statement
shall  thereafter  become  effective  in  accordance  with  Section  8(a) of the
Securities Act of 1933, as amended,  or until this Registration  Statement shall
become  effective on such date as the  Commission,  acting pursuant to aforesaid
Section 8(a), may determine.

<PAGE>




                                   PROSPECTUS

                             MEDTOX SCIENTIFIC, INC.

                        1,319,382 SHARES OF COMMON STOCK

         This Prospectus relates to the offer and sale of up to 1,319,382 shares
of Common Stock (the "Shares"),  par value $.15 per share, of Medtox Scientific,
Inc., a Delaware  corporation  (the "Company" or "Medtox"),  that may be offered
and sold from time to time by the  shareholders  described herein under "Selling
Shareholders."  These Shares include 649,230 shares underlying  warrants held by
the Selling  Shareholders  and 102,500  shares  underlying  options  held by the
Selling Shareholders.  The Selling Shareholders may offer their Shares from time
to time  through or to brokers or dealers  on the  American  Stock  Exchange  at
market  prices  prevailing  at the  time of  sale  or in one or more  negotiated
transactions at prices acceptable to the Selling Shareholders.  The Company will
not receive any  proceeds  from the sale of Shares by the Selling  Shareholders.
See "How the Shares May Be Distributed."

         The  Company  will bear all  expenses  of the  offering  (estimated  at
$18,999),   except  that  the  Selling  Shareholders  will  pay  any  applicable
underwriter's commissions and expenses, brokerage fees or transfer taxes.

         Medtox's  Common Stock is traded on the American  Stock  Exchange under
the symbol of "TOX." The closing sale price of the Medtox Common Stock on August
21, 2000 was $10.88 per share.

         The  Common  Shares  offered by this  Prospectus  are  speculative  and
involve a high degree of risk. See "Risk Factors" beginning on page 3.

         Neither the Securities and Exchange Commission nor any state securities
commission has approved or  disapproved  of these  securities or passed upon the
adequacy or accuracy of this prospectus. Any representation to the contrary is a
criminal offense.


                      The date of this Prospectus is September 8, 2000.


<PAGE>


                       WHERE YOU CAN FIND MORE INFORMATION

         We file annual,  quarterly, and current reports, proxy statements,  and
other  documents with the Securities and Exchange  Commission.  You may read and
copy any  document  we file at the  public  reference  room at  Judiciary  Plaza
Building, 450 Fifth Street, NW, Room 1024, Washington, DC 20549. You should call
1-800-SEC-0330 for more information on the public reference room. The Securities
and Exchange Commission maintains an internet site at  http://www.sec.gov  where
information regarding issuers (including Medtox) may be found.


         This prospectus is part of a registration  statement that we filed with
the Securities  and Exchange  Commission  (Registration  No.  333-44942).  The
registration  statement contains more information than this prospectus regarding
Medtox and its common stock,  including  exhibits and  schedules.  You can get a
copy of the  registration  statement  at the  address  listed  above or from the
internet site.


         The Securities and Exchange  Commission allows us to "incorporate" into
this prospectus  information we file with the Securities and Exchange Commission
in other documents. This means that we can disclose important information to you
by referring to other documents that contain that  information.  The information
may include  documents filed after the date of this prospectus  which update and
supersede  the  information  you  read in this  prospectus.  We  incorporate  by
reference the documents listed below,  except to the extent information in those
documents is different from the information  contained in this  prospectus,  and
all future  documents  filed under Sections  13(a),  13(c),  14, or 15(d) of the
Securities Exchange Act of 1934 until we terminate the offering of these shares:

o        Annual Report on Form 10-K for the Year ended December 31, 1999

o        Quarterly Reports on Form 10-Q for the Quarters ended March 31, 2000
         and June 30, 2000

o        Registration Statement on Form 8-A describing the common stock

         You may request a copy of these documents, at no cost, by writing to:

                             MEDTOX Scientific, Inc.
                       Attention: Chief Financial Officer
                             402 West County Road D
                               St. Paul, MN 55112
                               Phone: 651.636.7466
                                Fax: 651.628.6102

         You should rely only on the  information  incorporated  by reference or
provided  in  this  prospectus  or any  prospectus  supplement.  Medtox  has not
authorized anyone else to provide you with different information.  Medtox is not
making  an  offer  of these  securities  in any  state  where  the  offer is not
permitted.  You should not assume that the information in this prospectus or any
prospectus  supplement  is  accurate  as of any date  other than the date on the
front of those documents.

<PAGE>


                                 COMPANY SUMMARY

     Medtox  Scientific,   Inc.,  a  Delaware  corporation,   was  organized  in
September,  1986  to  succeed  to the  operations  of a  predecessor  California
corporation. Medtox Scientific, Inc. and its subsidiaries,  Medtox Laboratories,
Inc.  and Medtox  Diagnostics,  Inc.,  are  referred to in this  document as the
"Company." Medtox Laboratories,  Inc. is a toxicology  laboratory which provides
forensic  toxicology,  clinical  toxicology,  and heavy metals analyses.  Medtox
Diagnostics,  Inc.  develops,  manufactures  and markets on-site  diagnostic and
screening  tests  which are used to detect  substances  in  humans,  foodstuffs,
animals, feed and the environment.

                                  RISK FACTORS

         You should  consider  carefully the following risk factors,  along with
the  other  information  contained  in or  incorporated  by  reference  in  this
prospectus, in deciding whether to invest in our securities.

         1. We Have  Accumulated a Deficit From Net Losses and Cannot Be Certain
of Future  Profitability.  From June 1983 through December 31, 1999, the Company
accumulated  approximately  $47 million in losses from operations.  Although the
Company  earned money during 1997 and 1999,  the Company could lose money in the
future.

         2. We Have  Incurred  Debt to Finance  Our  Operations.  On January 14,
1998,  the Company  entered into a Credit  Security  Agreement (the "Wells Fargo
Credit  Agreement")  with Wells Fargo  Business  Credit.  The Wells Fargo Credit
Agreement,  as  amended,  consists  of (i) a term  loan of  $3,185,000,  bearing
interest at prime + 1.25%; (ii) an overadvance term loan of $1,350,000,  bearing
interest at prime + 4%; (iii) a revolving  line of credit equal to the lesser of
$6,000,000 or 85% of the Company's eligible trade accounts  receivable,  bearing
interest at prime + 1%; and (iv) a note of up to $1,800,000, for the purchase of
capital equipment bearing interest at prime + 1.25%.

                  As of June 30, 1999 the Company received $575,000 from selling
subordinated debt. The notes require payment of the principal amount on December
31, 2001. Interest at 12% per annum is paid twice a year on June 30 and December
31.

                  There  can  be no  assurance  that  the  Company  can  operate
profitably in the future.  Losses could impair the Company's  ability to pay its
debts.

         3. The Company's Products Could Become Outdated.  Modern  biotechnology
has changed and continues to change very quickly.  The Company requires adequate
financial resources in order to maintain a competitive  position with respect to
its  technology  and to  continue  to  attract  and retain  qualified  technical
personnel. These financial resources may be unavailable. The Company focuses its
research and development resources on those products which it believes will most
quickly maximize  revenue.  There can be no guarantee that future  technological
developments  will not cause the  Company's  existing  or  proposed  products to
become outdated.


         4.       The Company Faces Intense Competition in Both of its Business
                  Segments.

                  a. Laboratory Services. As of December 31, 1999, approximately
66 labs,  including MEDTOX, were certified by the Department of Health and Human
Services as having met the standards for Subpart C of Mandatory  Guidelines  for
Federal  Workplace Drug Testing Programs (59 FR 29916,  29925).  Competitors and
potential   competitors   include  forensic  testing  units  of  large  clinical

<PAGE>

laboratories and other independent laboratories,  specialized laboratories,  and
in-house testing facilities maintained by hospitals.

                  Competitive factors include reliability and accuracy of tests,
price structure, service, transportation and collection networks and the ability
to establish relationships with hospitals,  physicians,  and users of drug abuse
testing programs. It should be recognized, however, that many of the competitors
and  potential  competitors  have  substantially  greater  financial  and  other
resources than the Company.

                  The industry in which the Company competes is characterized by
service issues  including,  turn-around  time of reporting  results,  price, the
quality  and  reliability  of  results,  and  an  absence  of  patent  or  other
proprietary  protection.  In addition,  since tests performed by the Company are
not protected by patents or other proprietary  rights,  any of these tests could
be performed by competitors.  However, there are proprietary assay protocols for
the more specialized testing that are unique to the Company.

                  The Company's  ability to  successfully  compete in the future
and  maintain  its margins  will be based on its ability to maintain its quality
and  customer  service  strength  while  maintaining  efficiencies  and low cost
operations.  There  can be no  assurance  that  price  competitiveness  will not
increase  in  importance  as a  competitive  factor  in the  laboratory  testing
business.

                  b. On-Site Diagnostic Tests. The diagnostics market has become
highly competitive with respect to the price, quality and ease of use of various
tests and is changing very  quickly.  The Company has designed its on-site tests
as inexpensive,  on-site tests for use by unskilled personnel, and has not tried
to compete with  laboratory-based  systems.  Many large  companies  with greater
research and development,  marketing, financial, and other capabilities, as well
as  government-funded  institutions  and smaller  research firms, are engaged in
research,  development and marketing of diagnostic assays for application in the
areas for which the Company produces its products.

                  The Company has experienced increased competition with respect
to its immunoassay tests from systems and products developed by others,  many of
whom  compete  solely  on  price.  Competing  technologies,  such  as  hair  and
saliva-based  on-site tests,  also compete with the Company's  on-site tests. As
the number of firms  marketing  diagnostic  tests has  grown,  the  Company  has
experienced  increased price competition.  A further increase in competition may
have a material adverse effect on the business and future financial prospects of
the Company.

         5.  Protection  of Our Patents  and  Proprietary  Information  Could be
Inadequate.  The Company holds nine issued United States patents. Eight of these
patents  generally  form the basis for the EZ-SCREEN and one-step  technologies.
Additionally,  the Company has one patent that relates to methods of using whole
blood as a sample  medium on its  immunoassay  devices.  The Company  also holds
various patents in several foreign countries.  The Company also holds two United
States  patents which it acquired in the  acquisition  of Granite  Technological
Enterprises, Inc. in 1986.

                  Of the eight U.S.  patents  mentioned  above,  which generally
form the basis for the EZ-SCREEN and one-step technologies, one expires in 2000,
one expires in 2004,  five expire in 2007,  and one expires in 2010.  The patent
which relates to the methods of using whole blood as a sample medium  expires in
2012.

                  There can be no  assurance  that there will not be a challenge
to the validity of the patents. If challenged,  the Company might be required to
spend  significant  funds to defend its  patents,  and there can be no assurance
that the Company would be successful in any such action.
<PAGE>

                  The  Company  holds  twelve   registered  trade  names  and/or
trademarks  in reference to its products and  corporate  names.  The trade names
and/or trademarks of the Company range in duration from ten to twenty years with
expiration dates from 2001 to 2008.  Additionally,  applications  have been made
for additional trade names.

                  The Company believes that the basic  technologies  required to
produce antibodies are in the public domain and are not patentable.  The Company
intends to rely upon trade secret protection of certain proprietary information,
rather than patents,  where it believes disclosure could cause the Company to be
vulnerable to competitors who could  successfully copy the Company's  production
and manufacturing techniques and processes.

                  6.  The  Company's   Business  and  Products  are  Subject  to
Extensive Government Regulation. The Company's products and services are subject
to the  regulations of a number of  governmental  agencies as listed below.  The
Company believes that it is currently in compliance with all the regulations and
requirements of such regulatory authorities.  The Company cannot predict whether
future  changes  in  governmental   regulations  might  significantly   increase
compliance  costs or adversely  affect the time or cost  required to develop and
introduce new products.  In addition,  the Company's  products are or may become
subject to  foreign  regulations.  Any  failure  by the  Company to comply  with
government  regulations or requirements  could have a material adverse effect on
the Company.

                  a. United States Food and Drug Administration  (FDA).  Certain
tests that the Company markets for  administration  to humans must be cleared by
the FDA  through  the  510(k)  process  prior to their  marketing  in the United
States.  The 510(k) process  requires the submission of information  and data to
the FDA that  demonstrates  that the  device  the  Company  wishes  to market is
substantially  equivalent to a device that is already being marketed.  This data
is generated by performing clinical studies comparing the results obtained using
the Company's device to those obtained using an existing test product.  Although
no  maximum  statutory  response  time  has  been  set for  review  of a  510(k)
submission,  as a matter of policy the FDA has  attempted to complete  review of
510(k)  submissions  within 90 days.  To date,  the Company has received  510(k)
clearance  for 11 different  products and the average time for  clearance was 72
days with a maximum of 141 days and a minimum of 20 days.  There is no assurance
that the Company will obtain FDA  approval on a timely  basis for future  510(k)
submissions and failure to receive  approval may have a material  adverse effect
on the Company's business, financial condition and operations.

                  As a registered  manufacturer of FDA regulated  products,  the
Company  is  subject  to  a  variety  of  FDA  regulations  including  the  Good
Manufacturing  Practices  ("GMP")  regulations which define the conditions under
which FDA regulated products are to be produced.  These regulations are enforced
by FDA and failure to comply with GMP or other FDA regulations can result in the
delay of premarket product reviews,  fines, civil penalties,  recall,  seizures,
injunctions  and criminal  prosecution.  If the Company fails to comply with the
FDA's regulatory  requirements,  the Company would be subject to FDA enforcement
activities which may have a material  adverse effect on the Company's  business,
financial condition and operations.

                  b. Health Care Financing  Administration  (HCFA). The Clinical
Laboratory  Improvement Act (CLIA) introduced in 1992 requires that all in vitro
diagnostic products be categorized as to level of complexity. A request for CLIA
categorization  of  any  new  clinical  laboratory  test  system  must  be  made
simultaneously with FDA 510(k) submission. The complexity category assigned to a
laboratory test system may limit the number of laboratories qualified to use the
test system thus  impacting  product  sales.  The in vitro  diagnostic  products
manufactured  and/or sold by the Company  have been  categorized  as  moderately
complex,  which  permits  use of the  products  in both  physician  offices  and
clinical   laboratories   which  meet  certain  quality  control  and  personnel
standards.  There can be no assurance  that any future  products  will receive a

<PAGE>

favorable complexity category.  Any failure to receive such favorable complexity
category may have a material  adverse  effect on the Company.  In addition,  the
laboratory at MEDTOX is a CLIA licensed laboratory.

                  c.  United   States   Department   of  Defense   (DOD).   With
reclassification  of the Company's  contract with the DOD from  UNCLASSIFIED  to
SECRET, it has been necessary to establish  appropriate  security procedures and
facilities,  including  designation  of  a  Facility  Security  Officer  who  is
responsible for overseeing the security  system,  including  conduct of periodic
security audits by appropriate  defense agencies.  Additionally,  the Company is
now  subject to  periodic  audits of its  accounting  systems and records by the
Defense Audit Agency.

                  d. Drug Enforcement Administration (DEA). The primary business
of the Company  involves  either  testing for drugs of abuse or developing  test
kits for the detection of drugs/drug  metabolites in urine.  MEDTOX Laboratories
is  registered  with  the  DEA to  conduct  chemical  analyses  with  controlled
substances. The Company's manufacturing facility in North Carolina is registered
by the DEA to manufacture  and distribute  controlled  substances and to conduct
research with controlled substances. Maintenance of these registrations requires
that the Company comply with applicable DEA regulations.  The Company's  failure
to maintain the required DEA registrations  would have a material adverse effect
on the  Company's  ability to develop and produce  drug test kits and to provide
laboratory testing services thus adversely  effecting the Company's business and
financial condition.

                  e. Substance Abuse and Mental Health  Services  Administration
(SAMHSA).  MEDTOX  Laboratories has been certified by SAMHSA since 1988.  SAMHSA
certifies  laboratories  meeting strict  standards  under Subpart C of Mandatory
Guidelines for Federal Workplace Drug Testing Programs.  Continued certification
is accomplished  through periodic inspection by SAMHSA to assure compliance with
applicable  regulations.  The Company's failure to maintain SAMHSA certification
would limit the  potential  client base to which  laboratory  services  could be
marketed,  thus  adversely  impacting  revenues from  laboratory  operations and
producing a material adverse impact on the Company.

                  f. Additional Laboratory Regulations.  MEDTOX Laboratories and
certain of the  laboratory  personnel  are  licensed or  otherwise  regulated by
certain federal agencies,  states,  and localities in which the Company conducts
business.  Federal,  state and local laws and  regulations  require the Company,
among other things, to meet standards governing the qualifications of laboratory
owners and personnel, as well as the maintenance of proper records,  facilities,
equipment,  test materials,  and quality control programs.  In addition,  MEDTOX
Laboratories  is  subject  to a  number  of  other  federal,  state,  and  local
requirements   which  provide  for  inspection  of  laboratory   facilities  and
participation  in  proficiency  testing,  as well as govern the  transportation,
packaging,   and  labeling  of  specimens  tested  by  either  laboratory.   The
laboratories  are also subject to laws and regulations  prohibiting the unlawful
rebate of fees and limiting the manner in which business may be solicited.

         MEDTOX  Laboratories  receives and uses small  quantities  of hazardous
chemicals and radioactive  materials in its operations and is licensed to handle
and dispose of such chemicals and materials.  Any business handling or disposing
of hazardous and  radioactive  waste is subject to potential  liabilities  under
certain of these laws.

         7. We Are Dependent on Key Personnel.  Although the Company believes it
has been successful to date in recruiting and retaining qualified personnel, the
growth of the  Company is  dependent  on its  ability to continue to attract the
services of qualified executive,  technical and marketing personnel. The Company
currently  does not maintain  any life  insurance  policy on any key  personnel.
There can be no assurance the Company will be able to attract and retain the key
personnel it requires.
<PAGE>

         8. The  Company's  Stock  Price  Could  Be  Volatile.  Factors  such as
announcement  of  technological  innovations or new  commercial  products by the
Company or its competitors, governmental regulation, patent or proprietary right
developments, or public safety and health concerns may have a significant impact
on the  market  price of the  Company's  securities.  In  addition,  resales  of
securities by shareholders may add significantly to volatility.  Moreover, there
has been a history  in recent  years of  significant  volatility  in the  market
prices for securities of biotechnology companies.

         9. We Have Engaged in  Transactions  With Insiders.  The Company has in
the past engaged in a number of material  transactions  with its  directors  and
executive  officers and may engage in such transactions in the future.  All such
transactions  have been in the past,  and will be in the  future,  approved by a
majority of the Company's disinterested directors.

         10.      The Company Has Never Paid  Dividends.  The  Company's
ability to declare or pay such  dividends  is  restricted  by certain  covenants
in the Wells Fargo Credit  Agreement.  Therefore,  the Company's  stock may not
be a suitable  investment for people seeking dividend income.

         11. We Face  Potential  Product  Liability  Claims.  Manufacturing  and
marketing the Company's  products entail a risk of product  liability claims. On
August 13, 1993, the Company  procured  insurance  coverage  against the risk of
product liability arising out of events after such date, but such insurance does
not cover  claims  made after that date based on events that  occurred  prior to
that date. Consequently,  for uncovered claims, the Company could be required to
pay any and all costs  associated  with any  product  liability  claims  brought
against it, the cost of defense whatever the outcome of the action, and possible
settlement  or damages if a court  rendered a judgment in favor of any plaintiff
asserting  such a claim  against  the  Company.  Damages  may  include  punitive
damages,  which may substantially  exceed actual damages.  The obligation to pay
such damages could have a material  adverse effect on the Company and exceed its
ability to pay such  damages.  The Company is unaware of any  product  liability
claims that are pending against it.

         The MEDTOX  laboratory  testing  services are primarily  diagnostic and
expose  the  laboratory  to the  risk  of  liability  claims.  The  Company  has
maintained  continuous  professional and general  liability  insurance  coverage
since 1984. To date the Company has not had any substantial  liability and there
are no  material  professional  service  claims  currently  pending  against the
Company.

                  RISKS RELATING TO FORWARD LOOKING STATEMENTS

         Certain  statements  contained in this prospectus,  including,  without
limitation,  statements  containing the words "believes,"  "anticipates," "may,"
"intends,"  "expects" and words of similar import,  constitute  "forward-looking
statements" within the meaning of the Private  Securities  Litigation Reform Act
of  1995.   Forward-looking   statements   involve  known  and  unknown   risks,
uncertainties  and other factors that may cause our actual results,  performance
or achievements (or industry results,  performance or achievements) expressed or
implied by these forward-looking  statements to be substantially  different from
those  predicted.  The factors that could affect our actual results  include the
following:

o        general economic and business conditions, both nationally and
         internationally

o        competition

o        changes in business strategy or development plans
<PAGE>

o        technological, evolving industry standards, or other problems that
         could delay the sale of our products

o        our inability to obtain  appropriate  licenses from third parties,
         protect our trade secrets,  operate  without  infringing  upon the
         proprietary rights of others, or prevent others from infringing on
         our proprietary rights

o        our inability to obtain sufficient financing to continue to expand
         operations

o        changes in demand for products and services by our customers

         Certain of these factors are discussed in more detail elsewhere in this
prospectus, including under the caption "Risk Factors." You should also consider
carefully the risks  described in this  prospectus or detailed from time to time
in our filings with the Securities and Exchange Commission.

         We do not  undertake any  obligation  to publicly  update or revise any
forward-looking  statements  contained in this  prospectus  or  incorporated  by
reference,  whether as a result of new information,  future events or otherwise.
Because  of these  risks  and  uncertainties,  the  forward-looking  events  and
circumstances discussed in this prospectus might not transpire.

                        PROCEEDS FROM THE SALE OF SHARES

         We will not receive any proceeds  from the sale of shares of our common
stock by the selling shareholders. However, we may receive up to $8,115,375 from
the  exercise of  warrants  and  $896,875  from the  exercise  of options.  Such
proceeds, if any, will be used for working capital and other corporate purposes.

         We expect to incur expenses of approximately $18,999 in connection with
the registration of the Shares.

                              SELLING SHAREHOLDERS


         Set forth below are the names of the Selling  Shareholders,  the number
of shares of Common Stock of the Company  beneficially  owned by each of them on
the date hereof,  the percentage of the  outstanding  Common Stock owned and the
number of shares offered hereby.
<TABLE>
<CAPTION>

                                                                                   Number of        Securities
                                                                   Percent         Shares           Beneficially
                                                                   Common          Registered       Owned After
                                               Securities          Stock           for Sale         Completion of
     Name of Selling Shareholder           Beneficially Owned      Owned (1)       Hereby (2)       the Offering (3)
<S>                                  <C>                        <C>              <C>             <C>
--------------------------------------- ------------------------- --------------- --------------- ------------------
David B. Johnson Family Foundation      Common Stock     40,000       2.3%                80,000          0
                                        Warrants (4)     40,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
John F. Rooney                          Common Stock      4,000         *                  8,000          0
                                        Warrants          4,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Ellis Family Limited Partnership        Common Stock      7,500         *                 15,000          0
                                        Warrants          7,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Perkins Capital Management, Inc.        Common Stock      4,000         *                  8,000          0
Profit Sharing Plan                     Warrants          4,000
--------------------------------------- ------------------------- --------------- --------------- ------------------

<PAGE>
                                                                                   Number of        Securities
                                                                   Percent         Shares           Beneficially
                                                                   Common          Registered       Owned After
                                               Securities          Stock           for Sale         Completion of
     Name of Selling Shareholder           Beneficially Owned      Owned (1)       Hereby (2)       the Offering (3)
--------------------------------------------------------------------------------------------------------------------
Industricorp & Co., Inc FBO Twin        Common Stock     25,000         *                 50,000          0
City Carpenters Pension Plan            Warrants         25,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Pyramid Partners, L.P.                  Common Stock     40,000       2.3%                80,000          0
                                        Warrants         40,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Piper Jaffray as Custodian FBO Harold   Common Stock      5,000         *                 10,000          0
Roitenberg IRA                          Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Sandra J. Hale                          Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian          Common Stock      2,500         *                  5,000          0
FBO Mark Halsten IRA                    Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Marla C. Kennedy                        Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
William R. Kennedy                      Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Margaret Velia Kinney                   Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
E. Robert Kinney                        Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
MB Partnership                          Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
The Miller Family Trust                 Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Strickland Family Limited Partnership   Common Stock      4,000         *                  8,000          0
                                        Warrants          4,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Christopher T. Dahl                     Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Edward E. Strickland                    Common Stock      4,000         *                  8,000          0
                                        Warrants          4,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Richard W. Perkins Trustee FBO          Common Stock      5,000         *                 10,000          0
Richard W. Perkins Trust                Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Pamela L. Brown, Trustee FBO            Common Stock      2,500         *                  5,000          0
Pamela L. Brown Trust                   Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Perkins Foundation                      Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Perkins and Partners Profit Sharing     Common Stock      5,000         *                 10,000          0
Plan & Trust                            Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Dr. Devron Char                         Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Donald M. & Pauline H. Roux JT          Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Piper Jaffray as Custodian FBO          Common Stock      2,500         *                  5,000          0
James H. Lehr SEG/IRA                   Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Rockford, Inc. Pension & Profit         Common Stock      2,500         *                  5,000          0
Sharing Plan & Trust                    Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Daniel W. O'Brien                       Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Elliot A. and Jean E. Cobb Joint        Common Stock      2,500         *                  5,000          0
Account                                 Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------

<PAGE>
                                                                                   Number of        Securities
                                                                   Percent         Shares           Beneficially
                                                                   Common          Registered       Owned After
                                               Securities          Stock           for Sale         Completion of
     Name of Selling Shareholder           Beneficially Owned      Owned (1)       Hereby (2)       the Offering (3)
--------------------------------------- ------------------------- --------------- --------------- ------------------
Dorsey & Whitney Retirement Trust FBO   Common Stock      2,500         *                  5,000          0
Thomas O. Moe                           Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian Gary     Common Stock      2,500         *                  5,000          0
B. Davis SEG/IRA                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock      2,000         *                  4,000          0
Daniel S. Perkins IRA                   Warrants          2,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Daniel S. Perkins, Trustee FBO Daniel   Common Stock      3,500         *                  7,000          0
S. Perkins                              Warrants          3,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock      1,500         *                  3,000          0
Patrice M. Perkins IRA                  Warrants          1,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Patrice M. Perkins Trust                Common Stock      3,500         *                  7,000          0
                                        Warrants          3,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock      3,500         *                  7,000          0
James G. Peters, Sr. IRA                Warrants          3,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock      4,500         *                  9,000          0
David H. Potter IRA                     Warrants          4,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Robert G. Allison                       Common Stock     10,000         *                 20,000          0
                                        Warrants         10,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Gary A. Bergren                         Common Stock      3,000         *                  6,000          0
                                        Warrants          3,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Craig L. Campbell                       Common Stock      3,000         *                  6,000          0
                                        Warrants          3,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock     10,000         *                 20,000          0
Bradly A. Erickson IRA                  Warrants         10,000
-------------------------------------- ------------------------- --------------- --------------- ------------------
Dennis D. Gonyea                        Common Stock      5,000         *                 10,000          0
                                        Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Dorothy J. Hoel                         Common Stock      5,000         *                 10,000          0
                                        Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock      2,500         *                  5,000          0
Charles W. Pappas IRA                   Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock     13,200         *                 26,400          0
Richard C. Perkins IRA                  Warrants         13,200
--------------------------------------- ------------------------- --------------- --------------- ------------------
Richard C. Perkins                      Common Stock      5,000         *                 10,000          0
                                        Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
John T. Potter                          Common Stock      3,000         *                  6,000          0
                                        Warrants          3,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Scott E. and Mary T. Strickland         Common Stock      3,000         *                  6,000          0
                                        Warrants          3,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
David M. Westrum, TTEE FBO David M.     Common Stock      3,000         *                  6,000          0
Westrum Revocable Living Trust          Warrants          3,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Shawn P. Weinand                        Common Stock      2,800         *                  5,600          0
                                        Warrants          2,800
--------------------------------------- ------------------------- --------------- --------------- ------------------
Stephen E. Kairies                      Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Jeff Dobbs                              Common Stock      5,000         *                 10,000          0
                                        Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Dan Dryer                               Common Stock      5,000         *                 10,000          0
                                        Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
<PAGE>
                                                                                   Number of        Securities
                                                                   Percent         Shares           Beneficially
                                                                   Common          Registered       Owned After
                                               Securities          Stock           for Sale         Completion of
     Name of Selling Shareholder           Beneficially Owned      Owned (1)       Hereby (2)       the Offering (3)
--------------------------------------- ------------------------- --------------- --------------- ------------------
Dr. Paul C. and Nancy S. Seel           Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Luke W. Vidor                           Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
USB Piper Jaffray as Custodian FBO      Common Stock      2,500         *                  5,000          0
James B. Wallace                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
First Bank NE TTEE for John Albers      Common Stock      7,500         *                 15,000          0
                                        Warrants          7,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Kevin McHale                            Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Donald A. Johnson                       Common Stock      5,000         *                 10,000          0
                                        Warrants          5,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
John & Catherine Oglesby Ten Com        Common Stock     23,000         *                 46,000          0
                                        Warrants         23,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Jeffrey E. O'Neil                       Common Stock      2,000         *                  4,000          0
                                        Warrants          2,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
First Trust Assoc. as TTEE              Common Stock      2,500         *                  5,000          0
Jon G. Nelson IRA                       Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Jeff Walker and Susan E. Walker         Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Kenneth G. Benson                       Common Stock      3,000         *                  6,000          0
                                        Warrants          3,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Nicholas Strenglis                      Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
John J. Altmann SR                      Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
John Altmann                            Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
J. Mark Lathers IRA                     Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Kyle Mansfield                          Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Steven J. Bateman                       Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Brian R. & Jennifer Johnson             Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Joseph Hendrickson                      Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
William H. Riviere & Renee Riviere      Common Stock      1,500         *                  3,000          0
                                        Warrants          1,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
First Trust Natl. Assoc. TTEE           Common Stock      2,500         *                  5,000          0
Thomas Tsatsos IRA                      Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Jeffrey D. Rahm & Susan Rahm            Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
David E. Riviere                        Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
Gary Kohler                             Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
<PAGE>

                                                                                   Number of        Securities
                                                                   Percent         Shares           Beneficially
                                                                   Common          Registered       Owned After
                                               Securities          Stock           for Sale         Completion of
     Name of Selling Shareholder           Beneficially Owned      Owned (1)       Hereby (2)       the Offering (3)
--------------------------------------- ------------------------- --------------- --------------- ------------------
Pyramid Trading Ltd. Partnership        Common Stock    140,000       8.0%               280,000          0
                                        Warrants        140,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Paul Forsberg                           Common Stock     30,000         *                 60,000          0
                                        Warrants         30,000
--------------------------------------- ------------------------- --------------- --------------- ------------------
Ann S. Chudnofsky                       Common Stock      2,500         *                  5,000          0
                                        Warrants          2,500
--------------------------------------- ------------------------- --------------- --------------- ------------------
United States Drug Testing              Common Stock      2,500         *                  2,500          0
Laboratories, Inc.
--------------------------------------- ------------------------- --------------- --------------- ------------------
Miller, Johnson & Kuehn, Inc.           Warrants          9,446         *                  9,446          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
Miller, Johnson & Kuehn, Inc.           Warrants          5,000         *                  5,000          0
Investment Pool
--------------------------------------- ------------------------- --------------- --------------- ------------------
Joseph D. Leach                         Warrants         11,550         *                 11,550          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
David B. Johnson                        Warrants         10,877         *                 10,877          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
Paul R. Kuehn                           Warrants         10,877         *                 10,877          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
Stanley D. Rahm                         Warrants          3,625         *                  3,625          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
Eldon C. Miller                         Warrants          3,625         *                  3,625          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
National Medical Review Offices, Inc.   Common Stock     15,152         *                 15,152          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
Richard J. Braun                                     108,568(5)       3.1%        Options 50,000       58,568
--------------------------------------- ------------------------- --------------- --------------- ------------------
Harry McCoy                                          232,677(6)       6.4%        Options 50,000      182,677
--------------------------------------- ------------------------- --------------- --------------- ------------------
Peter Heath                                            3,059(7)         *         Options  2,500          559
--------------------------------------- ------------------------- --------------- --------------- ------------------
Miller Johnson & Kuehn FBO Brian                     12,127 (8)         *         Warrants 1,923        8,281 (8)
Johnson
--------------------------------------- ------------------------- --------------- --------------- ------------------
Dain Rauscher FBO Brian Johnson                      12,127 (8)         *         Warrants 1,923        8,281 (8)
--------------------------------------- ------------------------- --------------- --------------- ------------------
Charles Schwab & Co. FBO James                       13,037 (9)         *         Warrants 5,769        7,268
Lockhart
--------------------------------------- ------------------------- --------------- --------------- ------------------
John Mackay                             Warrants     3,846 (10)         *                  3,846          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
Jean Way Schoonover                     Warrants     7,692 (10)         *                  7,692          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
Sam Powell                                         104,126 (11)       3.0%        Warrants 7,692       96,434
--------------------------------------- ------------------------- --------------- --------------- ------------------
Ms. Linda Stillman                      Warrants    15,385 (12)         *                 15,385          0
--------------------------------------- ------------------------- --------------- --------------- ------------------
*        Less than 1.0%.

</TABLE>


(1)  Based on 3,504,347  shares of common stock issued and  outstanding as of
     the date of this prospectus.
(2)  Does not constitute a commitment to sell any or all of the stated number of
     shares of common  stock.  The number of shares of common stock offered will
     be determined  from time to time by the selling  shareholder  in his or her
     discretion.
(3)  Assumes all the shares of common stock are sold pursuant to this prospectus
     and that no other shares of common stock are acquired or disposed of by the
     selling shareholders prior to the termination of this prospectus.
(4)  All warrants have an exercise price of $12.50 unless otherwise noted.
(5)  Mr. Braun is our Chief Executive Officer. Includes 50,000 options
     registered hereunder having an exercise price of $8.75 per share.
(6)  Mr. McCoy is our President and Chairman. Includes 50,000 options
     registered hereunder having an exercise price of $8.75 per share.
(7)  Mr. Heath was our Chief Financial Officer until July 1998. Includes 2,500
     options registered hereunder having an exercise price of $8.75 per share.
(8)  Mr. Johnson is a director of the Company.  Mr. Johnson beneficially owns
     an aggregate of 8,281 shares of common stock and 3,846 warrants having an
     exercise price of $3.25.
(9)  Mr. Lockhart is our Chief Financial Officer. Includes 5,769 warrants
     registered hereunder having an exercise price of $3.25.
(10) The exercise price of the warrants is $3.25.
(11) Mr. Powell is a director of the Company.  Includes 7,692 warrants
     registered hereunder having an exercise price of $3.25.
(12) The exercise price of the warrants is $3.75.
<PAGE>


         The Company has agreed with the Selling  Shareholders  to file with the
Commission,  under the Securities  Act, a  Registration  Statement of which this
Prospectus  forms a part,  with  respect  to the resale of the  Shares,  and has
agreed to prepare and file such amendments and  supplements to the  Registration
Statement as may be necessary to keep the Registration Statement effective until
the earlier of (i) the date on which all of the Shares  have been sold,  or (ii)
the third anniversary of the date on which the Commission declares this Form S-3
effective.

                        HOW THE SHARES MAY BE DISTRIBUTED

         The  Selling  Shareholders  have  advised us that they may from time to
time sell all or a portion of the Shares offered in one or more  transactions on
the American Stock Exchange, or on any other exchange on which the Medtox common
stock may then be listed, in privately negotiated  transactions or otherwise, or
a combination  of such methods of sale, at market prices  prevailing at the time
of sale or prices  related to such  prevailing  market  prices or at  negotiated
prices.  The Selling  Shareholders  may effect such  transactions by selling the
shares  to or  through  broker-dealers,  and  such  broker-dealers  may  receive
compensation in the form of underwriting  discounts,  concessions or commissions
from the Selling  Shareholders and/or purchasers of the Shares for whom they may
act as agent (which compensation may be in excess of customary commissions). The
Selling  Shareholders and any participating  broker-dealers  may be deemed to be
"underwriters" within the meaning of Section 2(4) of the Securities Act of 1933.

         Neither the  Selling  Shareholders  nor we can  estimate at the present
time the amount of  commissions  or discounts,  if any, that will be paid by the
Selling Shareholders on account of their sales of the Shares from time to time.

         Because Miller Johnson & Kuehn,  Inc. is deemed to be an  "underwriter"
within the  meaning  of Section  2(11) of the  Securities  Act of 1933,  and the
Selling  Shareholders  may be deemed to be  underwriters  within the  meaning of
Section 2(11) of the Securities Act of 1933,  the Selling  Shareholders  will be
subject to prospectus  delivery  requirements  under the Securities Act of 1933.
Furthermore,  in the  event  of a  "distribution"  of  securities,  the  Selling
Shareholders, any selling broker-dealer,  and any "affiliated purchasers" may be
subject to Regulation M under the  Securities  Exchange Act of 1934, as amended,
which  prohibits  certain  activities  for the  purpose  of  pegging,  fixing or
stabilizing the price of securities in connection with an offering.

         Under the  securities  laws of certain  states,  the Shares may be sold
only  through  registered  or licensed  broker-dealers  or pursuant to available
exemptions from such requirements. In addition, in certain states the Shares may
not be sold unless the Shares have been  registered  or qualified for sale or an
exemption from such requirement is available and is complied with.

         We  will  pay  certain  expenses  in  connection  with  this  offering,
estimated to be  approximately  $18,999 but we will not pay for any underwriting
commissions and discounts, if any, or other expenses of the Selling Shareholders
except  counsel  fees not to exceed  $3,000.  We have  agreed to  indemnify  the
Selling Shareholders, their directors, officers, agents and representatives, and
any underwriters,  against certain  liabilities,  including certain  liabilities
under the Securities Act of 1933. The Selling  Shareholders  have also agreed to
indemnify  us,  our  directors,  officers,  agents and  representatives  against
certain  liabilities,  including certain liabilities under the Securities Act of
1933.


<PAGE>

                                  LEGAL MATTERS

         Certain legal matters  associated  with the Shares being offered hereby
will be passed upon for the Company by  Fredrikson & Byron,  P.A.,  Minneapolis,
Minnesota.

                                     EXPERTS

         The  consolidated   financial  statements  and  the  related  financial
statement  schedule  incorporated  in this  prospectus  by  reference  from  the
Company's  Annual Report on Form 10-K for the year ended  December 31, 1999 have
been audited by Deloitte & Touche LLP, independent  auditors, as stated in their
report, which is incorporated herein by reference, and have been so incorporated
in reliance  upon the report of such firm given upon their  authority as experts
in accounting and auditing.

     The consolidated  financial  statements of Medtox Scientific,  Inc. for the
year ended December 31, 1997,  incorporated  by reference in Medtox  Scientific,
Inc.'s  Annual  Report  (Form  10-K),  have been  audited  by Ernst & Young LLP,
independent auditors, as set forth in their report thereon,  incorporated herein
by reference.  Such consolidated financial statements are incorporated herein by
reference in reliance  upon such report  given on the  authority of such firm as
experts in accounting and auditing.



                                TABLE OF CONTENTS

                                                                      Page

        Where You Can Find More Information                              2
        Company Summary                                                  3
        Risk Factors                                                     3
        Risks Relating to Forward Looking Statements                     7
        Proceeds From the Sale of Shares                                 8
        Selling Shareholders                                             8
        How the Shares May Be Distributed                               13
        Legal Matters                                                   14
        Experts                                                         14




<PAGE>

                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution

The estimated expenses in connection with this offering are as follows:

  Securities and Exchange Commission Filing Fee                      $3,999
  Legal Fees and Expenses                                            12,000
  Accounting Fees and Expenses                                        2,000
  Miscellaneous                                                       1,000
                                                         ------------------
                  Total Expenses                                    $18,999
                                                         ==================

Item 15.  Indemnification of Directors and Officers.

         Our Certificate of Incorporation and Bylaws include provisions that (i)
eliminate the personal liability of our directors for monetary damages resulting
from  breaches of their  fiduciary  duty to the extent  permitted by the General
Corporation  Law of the State of Delaware and (ii)  indemnify  our directors and
officers to the fullest  extent  permitted by the Delaware  General  Corporation
Law,   including   circumstances   in   which   indemnification   is   otherwise
discretionary.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to our directors, officers, and controlling persons
pursuant to the foregoing provisions, or otherwise, we have been advised that in
the opinion of the Securities and Exchange  Commission such  indemnification  is
against  public  policy  as  expressed  in the  Securities  Act of 1933  and is,
therefore, unenforceable.

Item 16.  List of Exhibits.


         5.1      Opinion of Fredrikson & Byron, P.A. ("F&B")- Previously filed.
         23.1     Consent of Deloitte & Touche LLP
         23.2     Consent of Ernst & Young LLP
         23.3     Consent of Fredrikson & Byron, P.A. (included in the opinion
                  of F&B filed as Exhibit 5.1)- Previously filed.
         24.1     Power of Attorney (included on page II-4 of this
                  registration statement).


<PAGE>
Item 17.  Undertakings.

(a)      The undersigned Registrant hereby undertakes:

         (1) To file,  during any period in which it offers or sells securities,
a post-effective amendment to this registration statement to:

                  (i)      Include any prospectus required by section 10(a)(3)
                  of the Securities Act;

                  (ii)  Reflect in the  prospectus  any facts or events  arising
                  after the effective date of the Registration Statement (or the
                  most   recent   post-effective   amendment   thereof)   which,
                  individually  or in the  aggregate,  represent  a  fundamental
                  change  in the  information  set  forth  in  the  registration
                  statement; and

                  (iii) Include any additional material information with respect
                  to the plan of  distribution  not previously  disclosed in the
                  Registration   Statement  or  any  material   change  to  such
                  information in the Registration Statement.

Provided,  however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs is contained in periodic reports filed by the Registrant  pursuant to
section  13 or section  15(d) of the  Securities  Exchange  Act of 1934 that are
incorporated by reference in the Registration Statement.

         (2) That for  determining  liability  under the Securities Act of 1933,
each such  post-effective  amendment  shall be  deemed to be a new  registration
statement relating to the securities  offered therein,  and the offering of such
securities  at that time shall be deemed to be the  initial  bona fide  offering
thereof.

         (3) To remove from registration by means of a post-effective  amendment
any of the securities that remain unsold at the termination of the offering.

(b) Insofar as indemnification  for liabilities arising under the Securities Act
of 1933 may be permitted to directors,  officers and controlling  persons of the
Registrant pursuant to the foregoing  provisions,  or otherwise,  the Registrant
has been advised that in the opinion of the Securities  and Exchange  Commission
such indemnification is against public policy as expressed in the Securities Act
of  1933  and is,  therefore,  unenforceable.  In the  event  that a  claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  Registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against  public policy as expressed in the  Securities
Act of 1933 and will be governed by the final adjudication of such issue.


<PAGE>


(c)      The undersigned Registrant further undertakes that:

         (1) For purposes of determining  any liability under the Securities Act
of 1933, the  information  omitted from the form of prospectus  filed as part of
this  registration  statement in reliance upon Rule 430A and contained in a form
of  prospectus  filed by the  registrant  pursuant to Rule  424(b)(1)  or (4) or
497(h) under the Securities Act shall be deemed to be part of this  registration
statement as of the time it was declared effective.

         (2) For the purpose of determining  any liability  under the Securities
Act of 1933,  each  post-effective  amendment that contains a form of prospectus
shall be deemed to be a new  registration  statement  relating to the securities
offered  therein,  and the  offering  of such  securities  at that time shall be
deemed to be the initial bona fide offering thereof.

(d)  The  undersigned   Registrant  hereby  undertakes  that,  for  purposes  of
determining  any liability  under the Securities Act of 1933, each filing of the
Registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  Section  15(d)  of  the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
Registration  Statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.


<PAGE>



                                   SIGNATURES


         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of St. Paul, State of Minnesota, on September 6, 2000.


                                            MEDTOX Scientific, Inc.

                                            By: /s/ Richard J. Braun
                                                Richard J. Braun
                                                Chief Executive Officer
                                                (Principal Executive Officer)


                                POWER OF ATTORNEY

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities  and on the dates  indicated.  Each person  whose  signature  to this
Registration  Statement appears below hereby constitutes and appoints Richard J.
Braun and James B.  Lockhart,  and each of them,  as his or her true and  lawful
attorney-in fact and agent, with full power and substitution,  to sign on his or
her behalf individually and in the capacity stated below and to perform any acts
necessary  to be done  in  order  to  file  all  amendments  and  post-effective
amendments  to this  Registration  Statement,  and any  and all  instruments  or
documents filed as part of or in connection with this Registration  Statement or
the  amendments  thereto,  and each of the  undersigned  does hereby  ratify and
confirm all that said  attorney-in-fact  and agent,  or his or her  substitutes,
shall do or cause to be done by virtue hereof.

Signatures                              Title                         Date

/s/ Harry G. McCoy             Chairman of the Board          September 6, 2000
Harry G. McCoy                 and President


/s/ Richard J. Braun           Chief Executive Officer        September 6, 2000
Richard J. Braun               & Director

/s/ James B. Lockhart          Vice President of Finance,     September 6, 2000
James B. Lockhart              Chief Financial Officer
                               & Secretary

/s/ Samuel C. Powell, Ph.D.    Director                       September 6, 2000
Samuel C. Powell, Ph.D.

/s/ Miles E. Efron             Director                       September 6, 2000
Miles E. Efron

s/ James W. Hansen             Director                       September 6, 2000
James W. Hansen

s/ Brian Johnson               Director                       September 6, 2000
Brian Johnson


<PAGE>



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             MEDTOX SCIENTIFIC, INC.
                            EXHIBIT INDEX TO FORM S-3




Exhibit Number            Description


          5.1             Opinion of Fredrikson & Byron, P.A. ("F&B") -
                          Previously filed.

          23.1            Consent of Deloitte & Touche LLP

          23.2            Consent of Ernst & Young LLP

          23.3            Consent of Fredrikson & Byron, P.A. (included in the
                          opinion of F&B filed as Exhibit 5.1)- Previously
                          filed.

          24.1            Power of Attorney (included on pages II-4 of this
                          registration statement)



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