<PAGE> PAGE 1
000 A000000 04/30/2000
000 C000000 0000743861
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 JOHN HANCOCK INVESTMENT TRUST II
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001 C000000 6173751702
002 A000000 101 HUNTINGTON AVENUE
002 B000000 BOSTON
002 C000000 MA
002 D010000 02199
002 D020000 7603
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 Y
007 B000000 3
007 C010100 1
007 C010200 2
007 C020200 JOHN HANCOCK REGIONAL BANK FUND
007 C030200 N
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C020800 JOHN HANCOCK FINANCIAL INDUSTRIES FUND
007 C030800 N
007 C010900 9
007 C020900 JOHN HANCOCK SMALL CAP VALUE FUND
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007 C011000 10
007 C011100 11
007 C011200 12
007 C011300 13
007 C011400 14
007 C011500 15
007 C011600 16
007 C011700 17
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007 C011900 19
007 C012000 20
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<PAGE> PAGE 2
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007 C012400 24
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007 C013700 37
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008 A00AA01 JOHN HANCOCK ADVISERS, INC.
008 B00AA01 A
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008 D01AA01 BOSTON
008 D02AA01 MA
008 D03AA01 02199
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011 A00AA01 JOHN HANCOCK FUNDS, INC.
011 B00AA01 8-43582
011 C01AA01 BOSTON
011 C02AA01 MA
011 C03AA01 02199
011 C04AA01 7603
012 A00AA01 JOHN HANCOCK SIGNATURE SERVICES, INC.
012 B00AA01 84-1885
012 C01AA01 BOSTON
012 C02AA01 MA
012 C03AA01 02199
012 C04AA01 7603
013 A00AA01 PRICEWATERHOUSECOOPERS LLP
013 B01AA01 BOSTON
013 B02AA01 MA
013 B03AA01 02110
014 A00AA01 SIGNATOR INVESTORS, INC.
014 B00AA01 8-13995
014 A00AA02 JOHN HANCOCK FUNDS, INC.
014 B00AA02 8-43582
015 A00AA01 INVESTORS BANK & TRUST COMPANY
015 B00AA01 C
015 C01AA01 BOSTON
015 C02AA01 MA
015 C03AA01 02111
015 E01AA01 X
<PAGE> PAGE 3
015 A00AA02 CITIBANK, N.A. (ARGENTINA)
015 B00AA02 S
015 C01AA02 BUENOS AIRES
015 D01AA02 ARGENTINA
015 E04AA02 X
015 A00AA03 NATIONAL AUSTRALIA BANK LIMITED
015 B00AA03 S
015 C01AA03 MELBOURNE
015 D01AA03 AUSTRALIA
015 E04AA03 X
015 A00AA04 BANKAUSTRIA CREDITANSTALT
015 B00AA04 S
015 C01AA04 VIENNA
015 D01AA04 AUSTRIA
015 E04AA04 X
015 A00AA05 STANDARD CHARTERED BANK, DHAKA
015 B00AA05 S
015 C01AA05 DHAKA
015 D01AA05 BANGLADESH
015 E04AA05 X
015 A00AA06 PARIBAS
015 B00AA06 S
015 C01AA06 BRUSSELS
015 D01AA06 BELGIUM
015 E04AA06 X
015 A00AA07 BANKBOSTON BRAZIL
015 B00AA07 S
015 C01AA07 SAO PAULO
015 D01AA07 BRAZIL
015 E04AA07 X
015 A00AA08 ROYAL BANK OF CANADA
015 B00AA08 S
015 C01AA08 TORONTO
015 D01AA08 CANADA
015 E04AA08 X
015 A00AA09 STANDARD CHARTERED BANK, SHANGHAI
015 B00AA09 S
015 C01AA09 SHENZHEN
015 D01AA09 CHINA
015 E04AA09 X
015 A00AA10 STANDARD CHARTERED BANK, SHENZHEN
015 B00AA10 S
015 C01AA10 SHANGHAI
015 D01AA10 CHINA
015 E04AA10 X
015 A00AA11 CITIBANK, N.A. (JORDAN)
015 B00AA11 S
015 C01AA11 AMMAN
015 D01AA11 JORDAN
015 E04AA11 X
015 A00AA12 CITITRUST COLOMBIA S.A. (COLOMBIA)
<PAGE> PAGE 4
015 B00AA12 S
015 C01AA12 BOGOTA
015 D01AA12 COLOMBIA
015 E04AA12 X
015 A00AA13 CITIBANK, A.S.
015 B00AA13 S
015 C01AA13 PRAGUE
015 D01AA13 CZECH REPUBLIC
015 E04AA13 X
015 A00AA14 UNIBANK, A.S.
015 B00AA14 S
015 C01AA14 COPENHAGEN
015 D01AA14 DENMARK
015 E04AA14 X
015 A00AA15 EUROCLEAR/KANSALLIS-OSAKE-PANKKI
015 B00AA15 S
015 C01AA15 HELSINKI
015 D01AA15 FINLAND
015 E04AA15 X
015 A00AA16 PARIBAS
015 B00AA16 S
015 C01AA16 PARIS
015 D01AA16 FRANCE
015 E04AA16 X
015 A00AA17 EUROCLEAR/DEUTSCHE BANK A.G.
015 B00AA17 S
015 C01AA17 FRANKFURT
015 D01AA17 GERMANY
015 E04AA17 X
015 A00AA18 PARIBAS
015 B00AA18 S
015 C01AA18 ATHENS
015 D01AA18 GREECE
015 E04AA18 X
015 A00AA19 STANDARD CHARTERED BANK, HONG KONG
015 B00AA19 S
015 C01AA19 HONG KONG
015 D01AA19 HONG KONG
015 E04AA19 X
015 A00AA20 CITIBANK BUDAPEST RT.
015 B00AA20 S
015 C01AA20 BUDAPEST
015 D01AA20 HUNGARY
015 E04AA20 X
015 A00AA21 HSBC BANK MIDDLE EAST
015 B00AA21 S
015 C01AA21 MANAMA
015 D01AA21 BAHRAIN
015 E04AA21 X
015 A00AA22 STANDARD CHARTERED BANK,JAKARTA
015 B00AA22 S
<PAGE> PAGE 5
015 C01AA22 JAKARTA
015 D01AA22 INDONESIA
015 E04AA22 X
015 A00AA23 BANK OF IRELAND SECURITIES SERVICES
015 B00AA23 S
015 C01AA23 DUBLIN
015 D01AA23 IRELAND
015 E04AA23 X
015 A00AA24 PARIBAS
015 B00AA24 S
015 C01AA24 MILAN
015 D01AA24 ITALY
015 E04AA24 X
015 A00AA25 STANDARD CHARTERED BANK, TOKYO
015 B00AA25 S
015 C01AA25 TOKYO
015 D01AA25 JAPAN
015 E04AA25 X
015 A00AA26 STANDARD CHARTERED BANK, SEOUL
015 B00AA26 S
015 C01AA26 SEOUL
015 D01AA26 KOREA
015 E04AA26 X
015 A00AA27 EUROCLEAR/BANQUE ET CAISSE D'EPARGNE DEL'ETAT
015 B00AA27 S
015 C01AA27 LUXEMBOURG
015 D01AA27 LUXEMBOURG
015 E04AA27 X
015 A00AA28 STANDARD CHARTERED BANK MALAYSIA BERHAD
015 B00AA28 S
015 C01AA28 KUALA LUMPER
015 D01AA28 MALAYSIA
015 E04AA28 X
015 A00AA29 BANCOMER, S.A.
015 B00AA29 S
015 C01AA29 MEXICO CITY
015 D01AA29 MEXICO
015 E04AA29 X
015 A00AA30 MEESPIERSON
015 B00AA30 S
015 C01AA30 AMSTERDAM
015 D01AA30 NETHERLANDS
015 E04AA30 X
015 A00AA31 NATIONAL NOMINEES LIMITED
015 B00AA31 S
015 C01AA31 WELLINGTON
015 D01AA31 NEW ZEALAND
015 E04AA31 X
015 A00AA32 UNION BANK OF NORWAY
015 B00AA32 S
015 C01AA32 OSLO
<PAGE> PAGE 6
015 D01AA32 NORWAY
015 E04AA32 X
015 A00AA33 STANDARD CHARTERED BANK, KARACHI
015 B00AA33 S
015 C01AA33 KARACHI
015 D01AA33 PAKISTAN
015 E04AA33 X
015 A00AA34 CITIBANK, N.A. (PERU)
015 B00AA34 S
015 C01AA34 LIMA
015 D01AA34 PERU
015 E04AA34 X
015 A00AA35 STANDARD CHARTERED BANK, MANILA
015 B00AA35 S
015 C01AA35 MANILA
015 D01AA35 PHILIPPINES
015 E04AA35 X
015 A00AA36 BANK POLSKA KASA OPIEKI SA (PEKAO)
015 B00AA36 S
015 C01AA36 WARSAW
015 D01AA36 POLAND
015 E04AA36 X
015 A00AA37 CITIBANK PORTUGAL S.A.
015 B00AA37 S
015 C01AA37 LISBON
015 D01AA37 PORTUGAL
015 E04AA37 X
015 A00AA38 STANDARD CHARTERED BANK, SINGAPORE
015 B00AA38 S
015 C01AA38 SINGAPORE
015 D01AA38 SINGAPORE
015 E04AA38 X
015 A00AA39 THE STANDARD BANK OF SOUTH AFRICA LIMITED
015 B00AA39 S
015 C01AA39 CAPETOWN, PRETORIA
015 D01AA39 SOUTH AFRICA
015 E04AA39 X
015 A00AA40 PARIBAS
015 B00AA40 S
015 C01AA40 MADRID
015 D01AA40 SPAIN
015 E04AA40 X
015 A00AA41 STANDARD CHARTERED BANK, COLOMBO
015 B00AA41 S
015 C01AA41 COLOMBO
015 D01AA41 SRI LANKA
015 E04AA41 X
015 A00AA42 SVENSKA HANDELSBANKEN
015 B00AA42 S
015 C01AA42 STOCKHOLM
015 D01AA42 SWEDEN
<PAGE> PAGE 7
015 E04AA42 X
015 A00AA43 BANK LEU LTD.
015 B00AA43 S
015 C01AA43 ZURICH
015 D01AA43 SWITZERLAND
015 E04AA43 X
015 A00AA44 STANDARD CHARTERED BANK, TAIPEI
015 B00AA44 S
015 C01AA44 TAIPEI
015 D01AA44 TAIWAN
015 E04AA44 X
015 A00AA45 STANDARD CHARTERED BANK, BANGKOK
015 B00AA45 S
015 C01AA45 BANGKOK
015 D01AA45 THAILAND
015 E04AA45 X
015 A00AA46 OTTOMAN BANK
015 B00AA46 S
015 C01AA46 ISTANBUL
015 D01AA46 TURKEY
015 E04AA46 X
015 A00AA47 HSBC PLC
015 B00AA47 S
015 C01AA47 LONDON
015 D01AA47 UNITED KINGDOM
015 E04AA47 X
015 A00AA48 CESKOSLOVENSKA OBCHODNA BANKA A.S.
015 B00AA48 S
015 C01AA48 BRATISLAVA
015 D01AA48 SLOVAK REPUBLIC
015 E04AA48 X
015 A00AA49 CITIBANK, N.A. (CARACAS)
015 B00AA49 S
015 C01AA49 CARACAS
015 D01AA49 VENEZUELA
015 E04AA49 X
015 A00AA50 BARCLAYS BANK OF BOTSWANA LTD.
015 B00AA50 S
015 C01AA50 GARBORONE
015 D01AA50 BOTSWANA
015 E04AA50 X
015 A00AA51 CITIBANK, N.A. (ECUADOR)
015 B00AA51 S
015 C01AA51 QUITO
015 D01AA51 ECUADOR
015 E04AA51 X
015 A00AA52 BARCLAYS BANK OF GHANA LTD.
015 B00AA52 S
015 C01AA52 ACCRA
015 D01AA52 GHANA
015 E04AA52 X
<PAGE> PAGE 8
015 A00AA53 BARCLAYS BANK PLC
015 B00AA53 S
015 C01AA53 LUSAKA
015 D01AA53 ZAMBIA
015 E04AA53 X
015 A00AA54 BARCLAYS BANK PLC
015 B00AA54 S
015 C01AA54 HARARE
015 D01AA54 ZIMBABWE
015 E04AA54 X
015 A00AA55 CITIBANK, N.A. (EGYPT)
015 B00AA55 S
015 C01AA55 CAIRO
015 D01AA55 EGYPT
015 E04AA55 X
015 A00AA56 BANK HAPOALIM B.M.
015 B00AA56 S
015 C01AA56 JERUSALEM
015 D01AA56 ISRAEL
015 E04AA56 X
015 A00AA57 HONGKONG SHANGHAI BANKING CORP.
015 B00AA57 S
015 C01AA57 PORT LOUIS
015 D01AA57 MAURITIUS
015 E04AA57 X
015 A00AA58 CITIBANK - MAGHREB
015 B00AA58 S
015 C01AA58 RABAT
015 D01AA58 MOROCCO
015 E04AA58 X
015 A00AA59 CREDIT SUISSE (MOSCOW) LTD.
015 B00AA59 S
015 C01AA59 MOSCOW
015 D01AA59 RUSSIA
015 E04AA59 X
015 A00AA60 THE DEPOSITORY AND CLEARING CENTRE
015 B00AA60 S
015 C01AA60 LONDON
015 D01AA60 UNITED KINGDOM
015 E04AA60 X
015 A00AA61 THE BANK OF BERMUDA LIMITED
015 B00AA61 S
015 C01AA61 HAMILTON
015 D01AA61 BERMUDA
015 E04AA61 X
015 A00AA62 ING BANK
015 B00AA62 S
015 C01AA62 SOFIA
015 D01AA62 BULGARIA
015 E04AA62 X
015 A00AA63 BANKBOSTON, SANTIAGO
<PAGE> PAGE 9
015 B00AA63 S
015 C01AA63 SANTIAGO
015 D01AA63 CHILE
015 E04AA63 X
015 A00AA64 BANKAUSTRIA CREDITANSTALT
015 B00AA64 S
015 C01AA64 ZAGREB
015 D01AA64 CROATIA
015 E04AA64 X
015 A00AA65 HANSABANK
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015 C01AA65 TALLIN
015 D01AA65 ESTONIA
015 E04AA65 X
015 A00AA66 PARIBAS FRANKFURT
015 B00AA66 S
015 C01AA66 FRANKFURT
015 D01AA66 GERMANY
015 E04AA66 X
015 A00AA67 ANZ GRINDLAYS BANK
015 B00AA67 S
015 C01AA67 NEW DELHI
015 D01AA67 INDIA
015 E04AA67 X
015 A00AA68 ABN AMRO
015 B00AA68 S
015 C01AA68 ALMA-ATA
015 D01AA68 KAZAKSTAN
015 E04AA68 X
015 A00AA69 BARCLAYS BANK OF KENYA LTD.
015 B00AA69 S
015 C01AA69 NAIROBI
015 D01AA69 KENYA
015 E04AA69 X
015 A00AA70 HANSABANK
015 B00AA70 S
015 C01AA70 RIGA
015 D01AA70 LATVIA
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015 A00AA71 HSBC BANK MIDDLE EAST
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015 C01AA71 BEIRUT
015 D01AA71 LEBANON
015 E04AA71 X
015 A00AA72 VILNIAUS BANKAS AB
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015 C01AA72 VILNIUS
015 D01AA72 LITHUANIA
015 E04AA72 X
015 A00AA73 HSBC BANK MIDDLE EAST
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<PAGE> PAGE 10
015 C01AA73 MUSCAT
015 D01AA73 OMAN
015 E04AA73 X
015 A00AA74 BANKAUSTRIA CREDITANSTALT SECURITIES SA
015 B00AA74 S
015 C01AA74 BUCHAREST
015 D01AA74 ROMANIA
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015 A00AA75 BANK AUSTRIA CREDITANSTALT D.D. LJUBLJANA
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015 C01AA75 LJUBLJANA
015 D01AA75 SLOVENIA
015 E04AA75 X
015 A00AA76 ING BANK
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015 C01AA76 KIEV
015 D01AA76 UKRAINE
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015 A00AA77 BANKBOSTON MONTEVIDEO
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<PAGE> PAGE 11
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<PAGE> PAGE 12
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<PAGE> PAGE 13
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<PAGE> PAGE 14
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<PAGE> PAGE 15
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<PAGE> PAGE 16
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<PAGE> PAGE 17
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<PAGE> PAGE 18
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<PAGE> PAGE 19
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<PAGE> PAGE 20
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<PAGE> PAGE 21
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<PAGE> PAGE 22
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<PAGE> PAGE 23
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<PAGE> PAGE 24
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<PAGE> PAGE 25
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<PAGE> PAGE 26
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<PAGE> PAGE 27
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SIGNATURE SUSAN S. NEWTON
TITLE VICE PRESIDENT
