MACROCHEM CORP
DEF 14A, EX-99, 2000-06-02
PHARMACEUTICAL PREPARATIONS
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                             MACROCHEM CORPORATION
                              110 HARTWELL AVENUE
                         LEXINGTON, MASSACHUSETTS 02421
                    ----------------------------------------
                    Notice of Annual Meeting of Stockholders
                                 June 30, 2000
                    ----------------------------------------

     The undersigned  hereby appoints Alvin J. Karloff and Kenneth L. Rice, Jr.,
or either of them, with power of  substitution  to each,  proxies to vote at the
Annual Meeting of Stockholders of MacroChem Corporation,  to be held on June 30,
2000 at the  offices  of Ropes & Gray,  One  International  Place,  36th  Floor,
Boston,  Massachusetts,  at  10:00  a.m.,  local  time,  or at any  adjournments
thereof,  all of the  shares  of Common  Stock,  par value  $.01 per  share,  of
MacroChem  Corporation  that  the  undersigned  would  be  entitled  to  vote if
personally present. The undersigned  instructs such proxies or their substitutes
to act on the following matters as specified by the undersigned,  and to vote in
such manner as they may  determine on any other  matters that may properly  come
before the meeting.

     This proxy when properly executed will be voted in the manner directed by
the undersigned stockholder(s). If no contrary direction is made, this proxy
will be voted FOR the election of all nominees for director named on the
reverse, FOR the ratification of the selection of Deloitte & Touche LLP as
auditors for the fiscal year ending December 31, 2000 and in the discretion of
the named proxies as to any other matter that may properly come before the
meeting.

1.   Election of Directors:   FOR all nominees         _____
                              AGAINST all nominees     _____

     The undersigned hereby GRANTS authority to elect the following nominees as
     Directors.  Instructions:  To withhold authority to vote for any individual
     nominee, draw a line through that nominee's name.

     Nominees: Alvin J. Karloff
               Peter G. Martin
               Michael A. Davis
               Robert J. DeLuccia
               Paul S. Echenberg
               Peter G. Savas

2.   To ratify the appointment of Deloitte & Touche LLP, as independent auditors
     for the Corporation for the fiscal year ending December 31, 2000.

     FOR _____      AGAINST _____       ABSTAIN _____

3.   To consider and act upon any other matters that may properly come before
     the meeting or any adjournment thereof.

Please check box at right if you plan to attend meeting in person. _____

SIGNATURE
Title (if any)________________________________________________DATE_________

SIGNATURE
Title (if any)________________________________________________DATE_________

Note:  Please sign exactly as name appears on this card.  All joint owners
should sign.  When signing as executor, attorney, administrator or guardian or
as custodian for a minor, please give full title as such. If a corporation,
please sign in full corporate name and indicate signer's office.  If a
partnership, sign in the partnership name.



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