SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D/A
Amendment #2
Under the Securities Exchange Act of 1934
TRANSKARYOTIC THERAPIES, INC.
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(Name of Issuer)
Common Stock par value $.01 per share
- ---------------------------------------------------------------------------
(Title of Class of Securities)
893735 10 0
-----------------
(CUSIP Number)
Harry R. Benz
Hoechst Corporation
Route 202-206
P.O. Box 2500
Somerville, NJ 08876-1258
(517) 636-1000
- ---------------------------------------------------------------------------
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)
December 31, 1996
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(Date of Event Which Requires Filing of This Statement)
If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(b)(3) or (4), check the
following box. [ ]
Page 1 of 4
There are no Exhibits
<PAGE> 2
CUSIP No. 893735 10 0
___________________________________________________________________________
1) Name of Reporting Person and its Hoechst Corporation
I.R.S. Identification Number 22-1862783
___________________________________________________________________________
2) Check the Appropriate Box if (a)[ ]
a Member of a Group (b)[ ]
___________________________________________________________________________
3) SEC Use Only
___________________________________________________________________________
4) Source of Funds Not applicable
___________________________________________________________________________
5) Check Box if Disclosure of Legal [ ]
Proceedings is Required Pursuant
to Items 2(d) or 2(e)
___________________________________________________________________________
6) Citizenship or Place of Organization Delaware
___________________________________________________________________________
7) Sole Voting Power 0
Number of ____________________________________________________________
Shares
Beneficially 8) Shared Voting Power 0
Owned by ____________________________________________________________
Each
Reporting 9) Sole Dispositive Power 0
Person With ____________________________________________________________
10) Shared Dispositive Power 0
___________________________________________________________________________
11) Aggregate Amount Beneficially Owned 0
by Each Reporting Person
___________________________________________________________________________
12) Check Box If the Aggregate Amount [ ]
in Row (11) Excludes Certain Shares
___________________________________________________________________________
13) Percent of Class Represented 0%
by Amount in Row (11)
___________________________________________________________________________
14) Type of Reporting Person CO
___________________________________________________________________________
<PAGE> 3
This Amendment to the Statement on Schedule 13D (the "Schedule 13D")
of Hoechst Corporation, a Delaware corporation ("HCorp"), with respect to
the Common Stock of Transkaryotic Therapies, Inc. (the "Issuer"), is filed
solely to report the termination of HCorp's obligation to report beneficial
ownership of the Issuer's Common Stock on Schedule 13D.
Item 5(e) of the Statement on Schedule 13D of HCorp is hereby amended
to read as follows:
ITEM 5. INTEREST IN SECURITIES OF THE ISSUER.
- ------- -------------------------------------
(e) HCorp ceased to be the possible deemed beneficial owner of more
than five percent of the Issuer's Common Stock on December 31, 1996.
<PAGE> 4
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.
HOECHST CORPORATION
Date: January 6, 1997 By: /s/ David A. Jenkins
David A. Jenkins
Vice President, General
Counsel and Secretary
