PRUDENTIAL MUNICIPAL SERIES FUND
24F-2NT, 2000-11-13
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	U.S. SECURITIES AND EXCHANGE COMMISSION
	Washington, D.C.  20549

	FORM 24F-2
	Annual Notice of Securities Sold
	Pursuant to Rule 24f-2

	Read instructions at end of Form before preparing Form.
	Please print or type.



1.	Name and address of issuer: Prudential Municipal Series Fund, 100 Mulberry
Street, Gateway Center Three, Newark, New Jersey 07102-4077.

2.  Name of each series or class of funds for which this Form is filed
 (If the Form is being filed for all series and classes of securities of
 the issuer, check the box
but do not list series or classes):

	[X]

3.	Investment Company Act File Number:  811-4023.
Securities Act File Number: 2-91216.

4(a).Last day of fiscal year for which this Form is filed:  August 31, 2000.

	 (b).[ ] Check box if this Form is being filed late (i.e.
more than 90 calendar days after the end of the	issuer's fiscal year). (See
Instruction A.2)

Note: If the Form is being filed late, interest must be paid on the
registration fee due.

4(c).[ ] Check box if this is the last time the issuer will be filing
 this Form.

     5.	Calculation of registration fee:

    (i)	Aggregate sale price of securities
sold during the fiscal year pursuant
to section 24(f):			   $1,626,698,131

   (ii)	Aggregate price of securities redeemed
or repurchased during the fiscal year:

$1,685,672,973


	  (iii)	Aggregate price of securities redeemed
or repurchased during any prior fiscal
year ending no earlier than October 11,
1995 that were not previously used to
reduce registration fees payable to the
Commission:		                      $254,340,774

(iv)	Total available redemption credits
			[add Items 5(ii)and 5(iii)]:         $1,940,013,747

(v)	Net sales - If Item 5(i) is greater
			than Item 5(iv) [subtract Item 5(iv)
			from Item 5(i)]:				  	$     0

(vi)  Redemption credits available for use
		   in future years
		   -if Item 5(i) is less than Item 5(iv)
		  [subtract Item 5(iv) from Item (5(i)]: $(313,315,616)

(vii)  Multiplier for determining registration
		   fee (See instruction C.9):			   x   .000264

(viii)  Registration fee due [multiply Item 5(v)
		   by Item 5(vii)] enter "0" if no fee is
		   due.
	$______0_______

			6.	Prepaid Shares

		If the response to Item 5(i) was determined by deducting an amount of
securities that were registered under the Securities Act of 1933 pursuant to
ule 24e-2 as in effect October 11, 1997, then report the amount of securities
(number of shares or other units) deducted here:   0     . If there is a
number of shares or other units that were registered pursuant to rule
24e-2 remaining unsold at the end of the fiscal year for which this form is
filed that are available for use by the issuer in future fiscal years,
then state that number here:    0    .

	7.	Interest due - if this Form is being filed
    more than 90 days after the end of the of
    the issuer's fiscal year (See Instruction D):+$ 0

 	8.	Total amount of the registration fee due
 		plus any interest due [line 5(viii)plus
	line 7]:							 	=$ 0






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