SYNTHETECH INC
S-3/A, 1996-09-12
INDUSTRIAL ORGANIC CHEMICALS
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                                              September 11, 1996

VIA ELECTRONIC TRANSMISSION

Mr. Evan Callio
Securities & Exchange Commission
Division of Corporation Finance
450 Fifth Avenue, N.W.
Washington, D.C.  20549


RE:  Synthetech, Inc. Registration Statement on Form S-3
     File No. 333-8203


Dear Mr. Callio:

Pursuant to Rule 461 of the Securities Act of 1933, as amended, Synthetech,
Inc. hereby requests that the effective date of the above-captioned
Registration Statement be accelerated so that the Registration Statement
will become effective at 9:00 a.m. Eastern Standard Time on Thursday,
September 12, 1996, or as soon thereafter as practicable.

                                       SYNTHETECH, INC.

                                       BY:/s/  Charles B. Williams
                                               Charles B. Williams
                                               Vice President of Finance
                                               and Administration, Chief
                                               Financial Officer


<PAGE>
                                              September 11, 1996

VIA ELECTRONIC TRANSMISSION

Securities and Exchange Commission
Division of Corporation Finance
450 Fifth Avenue, N.W.
Washington, D.C.  20549

RE:  Synthetech, Inc.
     Amendment No. 1 to Registration Statement on Form S-3
     (File No. 333-8203)

Ladies and Gentlemen:

Synthetech, Inc. an Oregon corporation (the "Company"), in connection with
the proposed offering of 850,000 shares of the Company's common stock, hereby
attaches for filing pursuant to the requirements of the Securities Act of
1933, as amended, and the applicable rules and regulations thereunder, a copy
of Amendment No. 1 to the Registration Statement on Form S-3, marked to
indicate changes between the text thereof and of the Registration Statement
filed with the Securities and Exchange Commission on July 16, 1996.

If you have comments or require any further information with respect to this
filing, please call the undersigned (541-967-6575).

                                         Sincerely yours,

                                         /s/  Charles B. Williams
                                              Charles B. Williams
                                              Vice President of Finance
                                              and Administration, Chief
                                              Financial Officer 





<PAGE>
   
As filed with the Securities and Exchange Commission on September 12, 1996
    
                                            Registration No. 333-8203
                 SECURITIES AND EXCHANGE COMMISSION
                       Washington, D.C. 20549
       
                    AMENDMENT NO. 1 TO FORM S-3
       
                    REGISTRATION STATEMENT UNDER
                     THE SECURITIES ACT OF 1933
                                  
                          SYNTHETECH, INC.
       (Exact name of Registrant as specified in its charter)
                                  
      Oregon                                 84-0845771
     (State of                            (I.R.S. Employer
  Incorporation)                           Identification
                                                No.)
                    1290 Industrial Way
                   Albany, Oregon  97321
                       (541) 967-6575
    (Address, Including Zip Code, and Telephone Number,
  Including Area Code, of Registrant's Principal Executive
                          Offices)
                       M. Sreenivasan
           President and Chief Executive Officer
                      SYNTHETECH, INC.
                    1290 Industrial Way
                   Albany, Oregon  97321
                       (541) 967-6575
 (Name, Address, Including Zip Code, and Telephone Number,
         Including Area Code, of Agent for Service)
                         Copies to:
            Cynthia Clarfield Hess, Esq.  David R. Clarke, Esq.
            Sehar S. Ahmad, Esq.          VENTURE COUNSEL,
            PERKINS COIE                  P.C.
            1211 S.W. Fifth Avenue,       Suite 250
            Suite 1500                    1230 S.W. First Avenue
            Portland, OR 97204            Portland, Oregon  97204
            (503) 727-2000                (503) 225-9000
                                         
    Approximate date of commencement of proposed sale to the public:
        As soon as practicable after the effective date of this 
                        Registration Statement.
     
     If any securities being registered on this form are being
offered pursuant to dividend or interest reinvestment plans,
please check the following box.
     If any of the securities being registered on this form are to
be offered on a delayed or continuous basis pursuant to Rule 415
under the Securities Act of 1933, other than securities offered
only in connection with dividend or interest reinvestment plans,
check the following box.  X
   
                   CALCULATION OF REGISTRATION FEE
 Title of Each    Amount to   Proposed   Proposed     Amount
     Class           be       Maximum     Maximum       of
of Securities to  Registered  Offering   Aggregate   Registration
 be Registered               Price Per   Offering     
                              Share(1)   Price(1)      Fee(2)
Common Stock,      750,000     $8.00    $6,000,000   $2,069.00
$.001 par value
Common Stock,      100,000     $2.22     $222,000      $76.55
$.001 par value
Total              850,000         -    $6,222,000   $2,145.55          

(1)   Estimated solely for the purpose of calculating the
 registration fee under Rule 457.  The offering price has been
 estimated and the registration fee has been computed pursuant to
 Rule 457(c) based on (i) 750,000 Selling Shareholder shares at an   
 estimated price per share of $8.00 based on the average of the bid
 and asked price quoted for the Common Stock in the over-the-counter
 market on September 9, 1996 as reported on the Nasdaq SmallCap Market
 and (ii) 100,000 shares being issued pursuant to the exercise of warrants
 at an exercise price of $2.22.

(2)   A filing fee of $2,198.28 has previously been paid.
                                      
     The Registrant hereby amends this Registration Statement  on
such  date  or  dates as may be necessary to delay its  effective
date  until  the Registrant shall file a further amendment  which
specifically  states  that  this  Registration  Statement   shall
thereafter  become effective in accordance with Section  8(a)  of
the   Securities  Act  of  1933,  as  amended,  or   until   this
Registration Statement shall become effective on such date as the
Commission, acting pursuant to said Section 8(a), may determine.

<PAGE>                                  
      
                          850,000 Shares
                                  
                          SYNTHETECH, INC.
                                  
                           Common Stock
                                  
                                  
        
     The shares  of  common stock,  $.001 par value per share 
offered hereby (the "Shares") are shares of Synthetech,Inc.,  
an  Oregon corporation (the "Company"), 750,000 of which may be 
sold from time to time by a shareholder of   the   Company   (the
"Selling Shareholder") and 100,000 of which may be issued and sold 
from time to time by the Company upon exercise of certain warrants
(the "Warrants") to purchase Common Stock.  See "Selling Shareholder" 
and "Warrants."  The Company  will not  receive any  part of the
proceeds from the  sale  of  the Shares being sold by the Selling 
Shareholder in this offering (the "Offering").  The Company will 
receive proceeds from the exercise of the Warrants equal to the 
exercise price of $2.22 per share.

    
        
     The Common Stock was traded over-the-counter on the Nasdaq
Small  Cap  Market under the symbol "NZYM."  On  September  11,
1996,  the Common Stock was approved for trading on the  Nasdaq
National Market under the symbol "NZYM".  On September 9, 1996, the
average  of  the bid and asked price for the Common  Stock  was
$8.00 per share.
                                      
                                  
     
     See  "Risk Factors" beginning on page 3 of this Prospectus
for  a  discussion of certain factors that should be considered
by prospective purchasers of the Shares.
                                  
                                  
                                  
      THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY
         THE SECURITIES AND EXCHANGE COMMISSION NOR HAS THE
           COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY
             OF THIS PROSPECTUS.  ANY REPRESENTATION TO
                 THE CONTRARY IS A CRIMINAL OFFENSE.
<TABLE>
<CAPTION>
<S>                      <C>        <C>             <C>      <C>     
                                                       
                          Price to  Underwriting  Proceeds    Proceeds to
                          Public      Discounts      to         Selling
                                       and         Company   Shareholder(3)
                                    Commissions(1)                   
                                  
Per Share being sold        $8.00       $--           $0          $8.00
 by Selling Shareholder(1)
Per Share being sold        $2.22       $--          $2.22         $0 
 by the Company(2)
Total                    $6,222,000     $--        $222,000     $6,000,000
</TABLE>                          

(1)The Selling Shareholder may sell the Shares to or through dealers
   at market prices prevailing at the time of sale, at prices related
   to  such  prevailing market prices or at negotiated  prices.   The
   above  computations are based on the average of the bid and  asked
   price  of  the  Common  Stock as of  September 9,  1996  and  do  not
   necessarily  reflect the prices of shares to  the  public  on  the
   dates the transactions are actually effected.

(2)Based upon the exercise price of the Warrants of $2.22.

(3)Expenses of this Offering, estimated at $45,000, are payable by
   the Company.

                        
          The date of this Prospectus is September 12, 1996
                                      
<PAGE>    
                        AVAILABLE INFORMATION
     
     The  Company has filed a Registration Statement on Form S-3 (the
"Registration  Statement")  under the  Securities  Act  of  1933,  as
amended  (the  "Securities Act"), with the  Securities  and  Exchange
Commission (the "Commission"), Washington, D.C., with respect to  the
Shares  offered hereby.  The Prospectus does not contain all  of  the
information set forth in the Registration Statement and the  exhibits
thereto.  For further information with respect to the Company and the
Shares,  reference  is  made to the Registration  Statement  and  the
exhibits  thereto.   Statements made in this  Prospectus  as  to  the
contents  of  any  contract or other document  referred  to  are  not
necessarily complete, and in each instance reference is made  to  the
copy  of such contract or other document filed as an exhibit  to  the
Registration  Statement, each such statement being qualified  in  all
respects by such reference.
     
     The  Registration  Statement  is available  for  review  at  the
Commission's  offices  in  Washington,  D.C.   All  or  part  of  the
Registration Statement may be inspected and copied, upon  payment  of
the   prescribed  fees,  at  the  Public  Reference  Section  of  the
Commission, 450 Fifth Street N.W., Judiciary Plaza, Washington,  D.C.
20549-1004.
     
     In  addition,  the  Company  is  subject  to  the  informational
requirements of the Securities Exchange Act of 1934, as amended  (the
"Exchange  Act"),  and in accordance therewith files  reports,  proxy
statements and other information with the Commission.  Such  reports,
proxy  statements and other information can be inspected  and  copied
at,  and  copies of such material obtained at prescribed rates  from,
the  public  reference  facilities maintained by  the  Commission  at
450  Fifth Street, N.W., Judiciary Plaza, Washington, D.C. 20549-1004
and  at  the  Commission's regional offices located at 7 World  Trade
Center,  Suite  1300, New York, New York 10048 and  Citicorp  Center,
500 West Madison Street, Suite 1400, Chicago, Illinois 60661-2511.
     
     A  copy of the Company's 1996 Annual Report containing financial
statements  audited  by the Company's independent public  accountants
was  first mailed to the Shareholders on June 19, 1996.  The  Company
intends to continue to furnish Annual Reports to its Shareholders.
                                  
           INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
     
     The  following documents filed with the Commission  pursuant  to
the Exchange Act are incorporated in this Prospectus by reference:
        
     1.   The  Company's Annual Report on Form 10-KSB  for  the  year
          ended   March  31,  1996,  including  financial  statements
          incorporated by reference, as amended by Form 10-KSB/A as
          filed with the Commission on June 21, 1996.
     
     2.   The Company's Quarterly Report on Form 10-QSB for the quarter
          ended June 30, 1996, including financial statements incorporated
          by reference.
    
     3.   The description of the Company's Common Stock contained  in
    
          the  Registration  Statement on Form  8-A  filed  with  the
          Commission on November 8, 1984 under Section 12(g)  of  the
          Exchange Act.
     
     All  documents filed by the Company pursuant to Sections  13(a),
13(c),  14  or  15(d)  of the Exchange Act after  the  date  of  this
Prospectus  and  prior to the termination of this Offering  shall  be
deemed to be incorporated by reference in this Prospectus and to be a
part  hereof  from  the  date  of  filing  of  such  documents  (such
documents,  and  the  documents enumerated above,  being  hereinafter
referred to as "Incorporated Documents").
<PAGE>     
     Any  statement  contained in an Incorporated Document  shall  be
deemed  to  be modified or superseded for purposes of this Prospectus
and  the  Registration Statement of which it is a part to the  extent
that  a statement contained herein or in any other subsequently filed
Incorporated  Document  or in an accompanying  prospectus  supplement
modifies  or  supersedes  such  statement.   Any  such  statement  so
modified or superseded shall not be deemed, except as so modified  or
superseded,  to  constitute  a  part  of  this  Prospectus  or   such
Registration Statement.
     
     The Company will provide without charge to each person to whom a
copy  of  this Prospectus has been delivered, on the written or  oral
request  of any such person, a copy of any or all of the Incorporated
Documents,  other  than  exhibits  to  such  documents,  unless  such
exhibits   are   specifically  incorporated  by  reference   therein.
Requests should be directed to Charles B. Williams, Vice President of
Administration  and Finance, Chief Financial Officer,  Secretary  and
Treasurer,  at the Company's principal executive offices, Synthetech,
Inc., 1290 Industrial Way, Albany, Oregon 97321, telephone (541) 967-
6575.   The  information relating to the Company  contained  in  this
Prospectus  does not purport to be comprehensive and should  be  read
together   with   the  information  contained  in  the   Incorporated
Documents.
                                  
                            RISK FACTORS
        
     An investment in the shares of Common Stock offered hereby involves
a high degree of risk.  This Prospectus contains, in addition to historical
information, forward-looking statements that involve risks and uncertainties.
The Company's actual results could differ materially from the results
discussed in the forward-looking statements.  Prospective  investors  should 
consider the  following  factors, among  others, in making a decision 
concerning purchase of the shares of Common Stock offered hereby:
         
     Uncertain   Market   for   Products  and   Potential   Quarterly
Fluctuations.  The market for peptide building blocks  is  driven  by
the   market  for  the  peptide-based  drugs  into  which  they   are
incorporated.   The  drug  development process  is  dictated  by  the
marketplace,  drug  companies  and the regulatory  environment.   The
Company   has  no  control  over  the  pace  of  peptide-based   drug
development,  which  drugs get selected for  clinical  trials,  which
drugs are approved by the Food and Drug Administration ("FDA"),  and,
even  if  approved, the ultimate potential of such drugs.  Currently,
most of the Company's products are used in clinical-stage drugs which
are subject to a significant risk of suspension or early cancellation
and only a very small percentage of which are ultimately approved for
market  use.   Due  to  the  wide range of drugs  under  development,
sizable fluctuations in orders, and the unpredictability of order  or
reorder  cycles  for products, the Company does  not  have  a  stable
baseload of demand for its products and cannot estimate the potential
market  for its products.  The Company's customers vary substantially
from  year to year and the Company currently cannot rely on  any  one
customer as a constant source of revenue.  For the foregoing reasons,
the  Company has experienced in the past, and is likely to experience
in  the  future,  significant fluctuations in its quarterly  results.
Due to the small number of approved peptide-based drugs, there can be
no  assurance that a market for peptide building blocks will continue
to exist.
     
     Industry  Cost Factors.  The market for peptide building  blocks
is  dependent on the market for pharmaceuticals products.  The levels
of  revenues  and  profitability of pharmaceutical companies  may  be
affected  by  the continuing efforts of governmental and third  party
payors  to contain or reduce the cost of health care through  various
means.    For  example,  in  certain  foreign  markets,  pricing   or
profitability   of  prescription  pharmaceuticals   is   subject   to
government control.  In the United States, there have been,  and  the
Company  expects that there will continue to be, a number of  federal
and  state  proposals to implement similar government  controls.   In
addition,  in  both  the  United  States  and  elsewhere,  sales   of
prescription   pharmaceuticals  are  dependent   in   part   on   the
availability of reimbursement to the consumer from third party payors
such  as government and private insurance plans.  Third party  payors
are  increasingly challenging the prices charged for medical products
and  services.   There  can be no assurance that peptide-based  drugs
<PAGE>
will  be  considered cost effective, and that reimbursement  will  be
available or sufficient to allow peptide-based drugs to be sold on  a
profitable   basis.    In  addition,  as  cost   pressures   in   the
pharmaceutical  industry have tightened, the  cancellation  rate  for
drug  development programs has increased.  Because a majority of  the
Company's  revenues  historically have  come  from  peptide  building
blocks used in drug development programs, such cancellations may have
a significant impact on the Company's business.
<PAGE>     
     Regulatory  Matters.  The Company is subject  to  a  variety  of
federal, state and local laws, rules and regulations related  to  the
discharge   or  disposal  of  toxic,  volatile  or  other   hazardous
chemicals.   Although the Company believes that it is  in  compliance
with these laws, rules and regulations in all material respects,  and
to  date  has  not been required to take any action  to  correct  any
noncompliance,  the  failure  to  comply  with  present   or   future
regulations  could  result in fines being  imposed  on  the  Company,
suspension  of production or cessation of operations.  Third  parties
may  also have the right to sue to enforce compliance.  Moreover,  it
is   possible  that  increasingly  strict  requirements  imposed   by
environmental laws and enforcement policies thereunder could  require
the  Company to make significant capital expenditures.  The operation
of  a  chemical  manufacturing plant entails  the  inherent  risk  of
environmental  damage  or personal injury  due  to  the  handling  of
potentially  harmful substances, and there can be no  assurance  that
material  costs and liabilities will not be incurred  in  the  future
because of an accident or other event resulting in personal injury or
unauthorized  release  of such substances  to  the  environment.   In
addition, the Company generates hazardous materials and other  wastes
which are disposed at various offsite facilities.  The Company may be
liable,  irrespective of fault, for material cleanup costs  or  other
liabilities incurred at these disposal facilities in the event  of  a
release   of  hazardous  substances  by  such  facilities  into   the
environment.  The Company has obtained environmental risk insurance.
     
     Potential  Regulation.  The peptide building blocks produced  by
the Company are intermediate ingredients which are then processed  by
the companies to which they are sold, and are therefore currently not
subject to the requirements of the FDA.  The Company's customers  do,
however,  typically impose inspection and quality assurance  programs
on  the  Company.  These programs involve materials handling,  record
keeping  and other requirements.  As many of the Company's  customers
are  requiring  increased processing by the Company of its  products,
the   Company  expects  these  compliance  programs  to  become  more
extensive.  The Company may not be able to comply with the applicable
requirements  or  such requirements may require  the  expenditure  of
significant capital.
     
     Product   Liability.    Use  of  the   Company's   products   in
pharmaceuticals  and the subsequent testing, marketing  and  sale  of
such  pharmaceuticals involves an inherent risk of product liability.
In  addition,  research  and development  activities  in  amino  acid
technology,  and the production of fine chemicals (including  organic
chemicals) may expose workers engaged in performing duties related to
such  activities to health hazards.  There can be no  assurance  that
claims for product liability will not be asserted against the Company
or  that  the Company would be able to successfully defend any  claim
that  may  be  asserted.   A product liability  claim  could  have  a
material adverse effect on the business and/or financial condition of
the Company.
     
     Competition.  The Company does not have a significant amount  of
direct    competition    because    peptide-based    pharmaceuticals,
particularly   those  which  utilize  synthetic  amino   acids,   are
relatively  new and the market for peptide building blocks  is  still
very  small.   As  the market continues to grow with multi-ton  order
sizes  becoming  more prevalent, the Company has begun  to  see  more
competition.   Current  competition  in  the  multi-kilo  or  smaller
quantities of natural amino acid based peptide building blocks  comes
primarily  from several European fine chemical companies.   Multi-ton
order  sizes of these natural peptide building blocks have  begun  to
attract   a  wider  group  of  domestic  and  international  chemical
companies.   In  the  area  of synthetic  amino  acid  based  peptide
building  blocks, the Company has competition on a selective  product
basis from fine chemical producers in Europe and Japan.
<PAGE>     
     Competition also increases for supplying peptide building blocks
for  drug  development programs that reach late clinical  trials  and
move  into  an  approved status as a result of  increased  quantities
typically  required  at  these  stages  and  pharmaceutical   company
requirements  to  have  second sources of  material  available.   The
Company's  competitors have technical, financial, selling  and  other
resources available to them that is significantly greater than  those
available to the Company.
     
     Risks  of  Technological Change.  The market for  the  Company's
products  is  characterized  by rapid changes  in  both  product  and
process  technologies.   The Company's future results  of  operations
will  depend  upon  its ability to improve and  market  its  existing
products  and  to successfully develop, manufacture  and  market  new
products.  There can be no assurance that the Company will be able to
continue  to improve and market its existing products or develop  and
market  new  products,  or that technological developments  will  not
cause  the  Company's products or technology to  become  obsolete  or
noncompetitive.
     
     Manufacturing  Capacity.   The  Company  currently  manufactures
peptide  building  blocks.   As  a  manufacturer,  the  Company  will
continually  face risks regarding the availability and costs  of  raw
materials  and  labor,  the  potential need  for  additional  capital
equipment,   increased  maintenance  costs,   plant   and   equipment
obsolescence  and  quality control.  Because the  Company  is  facing
manufacturing  capacity  constraints in its  existing  facility,  the
Company is in the process of constructing an additional plant at  its
Albany,  Oregon location to increase production capacity.  There  can
be  no  assurance  that completion of the new facility  will  not  be
subject to delays and that the existing facility will have sufficient
capacity  to meet the demand for the Company's products, particularly
in  the  event that several of the peptide-based drugs for which  the
Company  supplies  peptide  building  blocks  simultaneously   become
commercially successful.  A disruption in the Company's production or
distribution  could have a material adverse effect on  the  Company's
financial results.
     
     Uncertain  Ability  to Manage Growth.  The  Company  anticipates
that  in order to remain successful in its industry, the Company will
be  required  to  increase its production  and  employee  base.   The
Company anticipates these increases may place significant demands  on
the   Company's   management,  working  capital  and  financial   and
management control systems.  The Company may not be able to meet  the
demands of future growth.  Any inadequacies in these areas could have
a  material  adverse  effect  on  the Company's  business,  financial
condition and results of operations.
     
     Dependence on Key Personnel.  The Company is highly dependent on
the principal members of its senior management and key scientific and
technical  personnel.  The Company's success is also  dependent  upon
its  ability  to attract and retain additional qualified  scientific,
technical  and managerial personnel.  Significant competition  exists
for  such  personnel, and there can be no assurance that the  Company
will retain its key employees or that it will be able to attract  and
retain  such  other highly-qualified personnel as may be required  in
the future.  The Company does not have employment agreements with any
of its personnel or key man life insurance on the lives of any of its
personnel.  The inability of the Company to successfully hire, train,
and  retain qualified personnel could have an adverse effect  on  the
Company.
     
     Risks of International Business.  Sales to customers outside the
United  States  accounted for approximately 21% of the Company's  net
sales during the year ended March 31, 1996.  The Company expects that
international  sales  will  continue to  account  for  a  significant
percentage  of  net sales.  The Company's business  is  and  will  be
subject  to  the  risks  generally  associated  with  doing  business
internationally,   including  changes  in   demand   resulting   from
fluctuations  in exchange rates, foreign governmental regulation  and
changes  in economic conditions.  These factors, among others,  could
influence the Company's ability to sell its products in international
markets.  In addition, the Company's business is subject to the risks
associated  with  legislation  and regulation  relating  to  imports,
including quotas, duties or taxes and other charges, restrictions and
retaliatory  actions  on  imports to other  countries  in  which  the
Company's products may be sold or manufactured.
<PAGE>     
     Absence of Dividends.  The Company has not paid any dividends on
its  Common Stock since its inception and does not anticipate  paying
any dividends in the foreseeable future.  Earnings of the Company, if
any, are expected to be used to finance the development and expansion
of  the  Company's  business.  Any future decision  with  respect  to
dividends  will depend on future earnings, future capital  needs  and
the Company's operating and financial condition, among other factors.
See "Description of Securities--Common Stock."
     
     Volatility   of   Stock  Price.   There  has  been   significant
volatility  in  the  market  price of  the  Company's  common  stock.
Between  July  1,  1995  and June 30, 1996,  the  bid  price  of  the
Company's  common  stock ranged from $3.22 per share  to  $10.75  per
share.  The Common Stock is currently traded on the Nasdaq Small  Cap
Market.   Application has been made to have the Common Stock approved
for   trading  on  the  Nasdaq  National  Market,  which  market  has
experienced,  and is likely to experience in the future,  significant
price  and volume fluctuations that could adversely affect the market
price   of   the  Common  Stock  without  regard  to  the   Company's
performance.   The Company believes factors such as  fluctuations  in
financial  results and developments in its industry could  contribute
to  the  volatility of the price of Common Stock.  These factors,  as
well  as  general  economic conditions such  as  recessions  or  high
interest  rates, may adversely affect the market price of the  Common
Stock.
     
     Exercise  of Warrants and Options; Potential Adverse  Impact  of
Shares  Eligible  for Future Sales.  As of June 30,  1996,  1,044,260
shares  of  Common  Stock were subject to outstanding  stock  options
under  the Company's Stock Option Plan at a weighted average exercise
price  of  $3.57  per  share  and 25,000 shares  were  issuable  upon
exercise of outstanding warrants at a weighted average exercise price
of  $1.81  per  share.  While outstanding warrants  and  options  are
exercisable, the holders thereof have the opportunity to profit  from
a rise in the market price of the common stock.  The Company may find
it  more  difficult  to  raise additional equity  capital  while  the
warrants  and options are outstanding.  At any time when the  holders
might be expected to exercise their warrants and options, the Company
would  probably be able to obtain additional equity capital on  terms
more  favorable than those provided in the warrants and options being
exercised.   Holders of warrants and options do not have any  of  the
rights or privileges of stockholders of the Company prior to exercise
of the warrants and options.
     
     Sales  of  substantial amounts of the Company's common stock  in
the public market by existing shareholders could adversely affect the
price  of  the  common stock.  In addition to the 850,000  shares  of
common  stock  offered hereby, 8,417,791 shares are  freely  tradable
under the federal securities laws to the extent they are not held  by
affiliates  of the Company.  At June 30, 1996, 4,222,865 shares  were
eligible  for resale under Rule 144.  In general, under Rule  144  as
currently  in  effect,  any  person  (or  persons  whose  shares  are
aggregated) who has beneficially owned restricted securities  for  at
least two years is entitled to sell, within any three-month period, a
number  of shares that does not exceed the greater of (i) 1%  of  the
then  outstanding shares of the issuer's common stock  and  (ii)  the
average  weekly  trading  volume  during  the  four  calendar   weeks
preceding  such sale, provided that certain public information  about
the  issuer as required by Rule 144 is then available and the  seller
complies  with certain other requirements.  A person who  is  not  an
affiliate,  has  not been an affiliate within three months  prior  to
sale,  and  has beneficially owned the restricted securities  for  at
least  three years is entitled to sell such shares under Rule  144(k)
without regard to any of the limitations described above.
<PAGE>                                  
       
                        SELLING SHAREHOLDER
<TABLE>
<CAPTION>
<S>             <C>             <C>           <C>            <C>        
     
                                           Percentage of Outstanding
  Selling          Shares        Shares        Before         After
Shareholder     Beneficially   Registered       Sales         Sales
                    Owned       For Sale
                                  
JB Partners      2,000,000       750,000        14.8%          9.3%
</TABLE>
    ______________
*Less than 1%.
     
     Pursuant  to a Shareholders Agreement among JB Partners,  a  New
York  limited partnership ("JB"), and the then current directors  and
officers  of  the  Company who held shares of  the  Company's  Common
Stock, such shareholders have agreed to vote their shares in favor of
the  election to the Board of Directors of a person nominated by  JB.
Such  agreement  shall  terminate on the  earlier  to  occur  of  the
following:   (i)  JB's ownership of common stock is reduced  to  less
than  500,000  shares,  (ii) the effectiveness  of  the  registration
statement  pursuant to JB's demand registration rights set  forth  in
its  Stock  and  Warrant  Purchase Agreement  with  the  Company,  as
amended,  (iii)  any merger, consolidation or reorganization  of  the
Company in which more than 50% of the voting power of the Company  is
transferred or (iv) March 31, 1998.

   
                           THE WARRANTS

     A total of 100,000 shares of Common Stock may be sold pursuant 
to this Prospectus upon exercise of the Warrants.  The Warrants were 
issued by the Company on December 31, 1991 at an exercise price of 
$2.22 per share and will expire on December 31, 1996.
     
                                       
                      DESCRIPTION OF SECURITIES
                                  

Common Stock
     
     The  authorized  capital  stock  of  the  Company  consists   of
100,000,000 shares of common stock, $.001 par value per share.  As of
May   30,  1996,  there  were  13,510,736  shares  of  common   stock
outstanding.  All of the outstanding shares of Common Stock are fully
paid and nonassessable.
     
     Holders of Common Stock are entitled to receive dividends as may
from  time to time be declared by the Board of Directors out of funds
legally  available therefor and to one vote per share on all  matters
on  which  the  holders of Common Stock are entitled  to  vote.   The
current policy of the Company is to retain earnings to provide  funds
for  the  operation and expansion of its business.  The  Company  has
never  paid any cash dividends, and the Board of Directors  does  not
anticipate  paying  cash  dividends in the foreseeable  future.   See
"Risk Factors--Absence of Dividends."  Holders of common stock do not
<PAGE>
have   any  cumulative  voting  rights  or  conversion,  pre-emptive,
redemption  or  sinking fund rights.  In the event of a  liquidation,
dissolution or winding up of the Company, holders of Common Stock are
entitled  to  share equally and ratably in the Company's  assets,  if
any, remaining after the payment of all liabilities of the Company.
     
     The  holders of Common Stock are entitled to one vote  for  each
share held on all matters submitted to the shareholders.
<PAGE>
Indemnification of Directors
     
     Article 7 of the Company's Articles provides that the Company is
required  to indemnify current or former directors of the Company  to
the  fullest extent permitted by the Oregon Business Corporation  Act
(the "Act").
     
     The  Company  has  entered into Indemnification Agreements  with
each  current  and  former  officer  and  director  documenting   and
detailing such indemnification rights. The Company expects  to  enter
into  similar  agreements with future officers  and  directors.   The
Company  has  obtained insurance for the protection of its  directors
and  officers  against any liability asserted against them  in  their
official  capacities, including coverage under  the  Securities  Act.
The  rights of indemnification under the Articles and the Act are not
exclusive of any other rights of indemnification to which the persons
indemnified  may  be  entitled under any bylaw,  agreement,  vote  of
shareholders  or  directors or otherwise. Insofar as  indemnification
for liabilities arising under the Securities Act may be permitted  to
directors,  officers or persons controlling the Company  pursuant  to
the  foregoing provisions, the Company has been informed that in  the
opinion  of the Securities and Exchange Commission (the "Commission")
such  indemnification is against public policy as  expressed  in  the
Securities Act and is therefore unenforceable.

Oregon Control Share and Business Combination Statutes
     
     The Company is subject to certain provisions of the Act that  in
certain   circumstances   restrict   the   ability   of   significant
shareholders from exercising voting rights (the "Control Share Act").
The   Control  Share  Act  generally  provides  that  a  person  (the
"Acquiring   Person")  who  acquires  voting  stock  of   an   Oregon
corporation  in a transaction that results in the Acquiring  Person's
holding  more than 20%, 33 1/3% or 50% of the total voting  power  of
the  corporation  (a  "Control Share Acquisition")  cannot  vote  the
shares the Acquiring Person acquires in the Control Share Acquisition
("control  shares") unless voting rights are accorded to the  control
shares  by (i) a majority of each voting group entitled to  vote  and
(ii)  the  holders  of a majority of the outstanding  voting  shares,
excluding the control shares held by the Acquiring Person and  shares
held  by  the corporation's officers and inside directors.  The  term
"Acquiring Person" is broadly defined to include persons acting as  a
group.
     
     The  Acquiring Person may, but is not required to, submit to the
corporation a statement setting forth certain information  about  the
Acquiring  Person and its plans with respect to the corporation.  The
statement  may  also  request  that the corporation  call  a  special
meeting  of shareholders to determine whether voting rights  will  be
accorded  to  the  control shares. If the Acquiring Person  does  not
request  a special meeting of shareholders, the issue of the  control
shares'  voting  rights  will be considered at  the  next  annual  or
special  meeting  of shareholders. If the Acquiring Person's  control
shares  are  accorded voting rights and represent a majority  of  all
voting  power, shareholders who do not vote in favor of voting rights
for  the  control shares will have the right to receive the appraised
"fair  value" of their shares, which may not be less than the highest
price paid per share by the Acquiring Person for the control shares.
     
     The  Company  is subject to certain provisions of the  Act  that
govern  business  combinations between  corporations  and  interested
shareholders,  which generally provides that if a  person  or  entity
acquires 15% or more of the voting stock of an Oregon corporation (an
"Interested   Shareholder"),  the  corporation  and  the   Interested
Shareholder,  or any affiliated entity of the Interested Shareholder,
<PAGE>
may not engage in certain business combination transactions for three
years following the date the person became an Interested Shareholder.
Business  combination  transactions for this purpose  include  (a)  a
merger  or  plan of share exchange, (b) any sale, lease, mortgage  or
other disposition of 10% or more of the assets of the corporation and
(c) certain transactions that result in the issuance of capital stock
of  the corporation to the Interested Shareholder. These restrictions
do  not  apply if (i) the Interested Shareholder, as a result of  the
transaction  in  which such person became an Interested  Shareholder,
owns  at least 85% of the outstanding voting stock of the corporation
(disregarding  shares owned by directors who are  also  officers  and
<PAGE>
certain employee benefit plans), (ii) the board of directors approves
the  share  acquisition or business combination before the Interested
Shareholder  acquired  15%  or more of the corporation's  outstanding
voting  stock or (iii) the board of directors and the holders  of  at
least  two-thirds of the outstanding voting stock of the  corporation
(disregarding shares owned by the Interested Shareholder) approve the
transaction after the Interested Shareholder acquires 15% or more  of
the corporation's voting stock.

Transfer Agent and Registrar
     
     The  transfer  agent  and  registrar for  the  Common  Stock  is
American Securities Transfer and Trust, Inc., Denver, Colorado.
                                  
                        PLAN OF DISTRIBUTION
     
     The  Shares  may  be  sold  from time to  time  by  the  Selling
Shareholders, or by pledgees, donees, transferees or other successors
in  interest.  Such sales may be made in the over-the-counter  market
or  otherwise  at prices and at terms then prevailing  or  at  prices
related   to   the  then  current  market  price,  or  in  negotiated
transactions.   The  Shares  may be  sold  by  one  or  more  of  the
following:   (a)  a  block trade in which the  broker  or  dealer  so
engaged will attempt to sell the Shares as agent but may position and
resell  a  portion  of  the  block as  principal  to  facilitate  the
transaction;  (b) a purchase by a broker or dealer as  principal  and
resale  by  such  broker or dealer for its account pursuant  to  this
Prospectus;  and (c) ordinary brokerage transactions and transactions
in which the broker solicits purchasers.  In effecting sales, brokers
or  dealers engaged by the Selling Shareholders may arrange for other
brokers  or dealers to participate.  Brokers or dealers will  receive
commissions or discounts from the Selling Shareholders in amounts  to
be negotiated immediately prior to the sale.  Such brokers or dealers
and  any other participating brokers or dealers may be deemed  to  be
"underwriters" within the meaning of the Securities Act in connection
with  such sales.  In addition, any Shares covered by this Prospectus
that qualify for sale pursuant to Rule 144 may be sold under Rule 144
rather than pursuant to this Prospectus.
     
     Under  agreements  that  may  be entered  into  by  the  Selling
Shareholders,  dealers  who participate in the  distribution  of  the
Shares may be entitled to indemnification by the Selling Shareholders
against   certain  liabilities,  including  liabilities   under   the
Securities Act.
     
     Certain  of the dealers may be customers of, including borrowers
from,  engage  in  transactions with, and perform services  for,  the
Company, a Selling Shareholder or one or more of their affiliates  in
the ordinary course of business.
   
     All of the Shares to be issued upon the exercise of the Warrants
are to be offered for the account of the Company.  The Company will not
pay any sales commissions or other seller's compensation in connection
with the exercise of the Warrants.  Shares issued upon the exercise of
the Warrants will be freely tradable by the holders thereof, subject to
compliance with applicable state securities laws and except for such shares
received by persons who may be deemed to be "affiliates" of the Company
(within the meaning of Rule 144).  Persons who are deemed to be affiliates
of the Company within the meaning of Rule 144 may not publicly offer or
sell such Shares received upon exercise of the Warrants except pursuant
to an effective registration statement under the Securities Act or
pursuant to Rule 144 (without regard to the applicable holding period
<PAGE>
provided thereunder).  The Company has not been advised when or whether
the holders of the Warrants intend to exercise their Warrants, or if they
do so, whether they intend to sell their securities received as a result
of such exercise.
                                      
                            LEGAL MATTERS
     
     The  validity of the Common Stock offered hereby has been passed
upon by Perkins Coie, Portland, Oregon.
                                  
                               EXPERTS
     
     The  financial  statements incorporated  by  reference  in  this
Prospectus and included in the Annual Report on Form 10-KSB  for  the
year  ended March 31, 1996 have been audited by Arthur Andersen  LLP,
independent  public accountants, as indicated in  their  report  with
respect  thereto,  and so incorporated herein in  reliance  upon  the
authority  of  said  firm as experts in auditing  and  accounting  in
giving said report.
<PAGE>
                                                      
   No dealer, salesperson or                       
any  other person  has  been                       
authorized   to   give   any                850,000 Shares
information or to  make  any                       
representations  other  than                       
those   contained  in   this                       
Prospectus   in   connection               SYNTHETECH, INC.
with   the  offer  contained                       
herein,  and,  if  given  or                 Common Stock
made,  such  information  or
representations must not  be
relied  upon as having  been
authorized by the Company or
by   any   of  the   Selling
Shareholder.           This
Prospectus     does      not
constitute an offer  of  any
securities other than  those
to  which it relates  or  an
offer   to   sell,   or    a
solicitation of an offer  to
buy,   those  to  which   it
relates in any state to  any
person  to  whom it  is  not
lawful to make such offer in
such state.  The delivery of
this  Prospectus at any time
does  not  imply  that   the
information    herein     is
correct   as  of  any   time
subsequent to its date.
                                                   
     TABLE OF CONTENTS                             
                        Page                       
Available Information     2                        
Incorporation of Certain                           
Documents                                 September 12, 1996  
  by Reference            2                        
Risk Factors              3                        
Selling Shareholder       7
Description of Securities 7
Plan of Distribution      9
Legal Matters             9
Experts                   9
Additional Information II-1
    
<PAGE>
                                                     
                                                   
                                                   
                                  
                               PART II
                                  
               INFORMATION NOT REQUIRED IN PROSPECTUS
<TABLE>
<CAPTION>
<S>                                             <C>  
Item 14.  Other Expenses of Issuance and Distribution
                                                      
                                                   Amount
          SEC Registration Fee                  $ 2,198.28
          Accounting Fees and Expenses*           1,000.00
          Legal Fees and Expenses*               30,000.00
          Blue Sky Fees and Expenses*             7,000.00
          Printing, including Registration      
          Statement, Prospectus,                  1,500.00
               etc.*
          Miscellaneous Expenses*                 3,301.72
                                                ----------
          TOTAL EXPENSES*                       $45,000.00
                                                ==========
</TABLE>
_____________

*Estimated

Item 15.  Indemnification of Directors and Officers
     
     As an Oregon corporation the Registrant is subject to the Oregon
Business  Corporation Act ("OBCA") and the exculpation from liability
and   indemnification  provisions  contained  therein.  Pursuant   to
Section  60.047(2)(d)  of the OBCA, Article  7  of  the  Registrant's
Articles  of Incorporation (the "Articles") eliminates the  liability
of  the  Registrant's directors to the Registrant or its shareholders
except  for  any  liability related to (i)  breach  of  the  duty  of
loyalty;  (ii)  acts or omissions not in good faith or  that  involve
intentional  misconduct  or a knowing violation  of  law;  (iii)  any
unlawful distribution under ORS 60.367; or (iv) any transaction  from
which the director derived an improper personal benefit.
     
     Section  60.391  of  the OBCA allows corporations  to  indemnify
their directors and officers against liability where the director  or
officer  has  acted in good faith and with a reasonable  belief  that
actions  taken  were in the best interests of the corporation  or  at
least  not opposed to the corporation's best interests and, if  in  a
criminal  proceeding,  the  individual had  no  reasonable  cause  to
believe  the  conduct  in  question was  unlawful.  Under  the  OBCA,
corporations may not indemnify against liability in connection with a
claim  by  or  in  the right of the corporation or for  any  improper
personal benefit in which the director or officer was adjudged liable
to   the   corporation.   Section  60.394  of   the   OBCA   mandates
indemnification   for  all  reasonable  expenses  incurred   in   the
successful  defense of any claim made or threatened  whether  or  not
such  claim  was  by  or  in the right of the  corporation.  Finally,
pursuant  to  the  Section  60.401 of the OBCA,  a  court  may  order
indemnification in view of all the relevant circumstances, whether or
not  the director or officer met the good-faith and reasonable belief
standards of conduct set out in Section 60.391 of the OBCA.
     
     Section  60.414  of  the OBCA also provides that  the  statutory
indemnification  provisions are not deemed  exclusive  of  any  other
rights  to  which  directors or officers  may  be  entitled  under  a
corporation's  articles  of incorporation or bylaws,  any  agreement,
general  or  specific  action  of the board  of  directors,  vote  of
shareholders or otherwise.
<PAGE>     
     The  Articles  provide  that  the  Registrant  is  required   to
indemnify  its  current and former directors to  the  fullest  extent
permitted  by  law.   Indemnification  Agreements  executed  by   all
directors  and officers of the Registrant obligate the Registrant  to
indemnify   such  individuals  for  liabilities  incurred   by   such
individuals while serving as directors or officers of the Registrant.

Item 16.  Exhibits.
       
Exhibit     Description
Number
          
5.1    Opinion of Perkins Coie regarding legality of the Common
       Stock being registered
       
23.1   Consent of Arthur Andersen LLP
       
23.2   Consent of Perkins Coie (included in the opinion filed as
       Exhibit 5.1)
       
*24.1  Power of Attorney

_________________
* Previously filed.
    
Item 17.  Undertakings.
     
     (a)  The undersigned registrant hereby undertakes:
          
          (1)   To  file, during any period in which offers or  sales
     are  being made, a post-effective amendment to this registration
     statement  to include any material information with  respect  to
     the  plan  of  distribution  not  previously  disclosed  in  the
     registration   statement  or  any  material   change   to   such
     information in the registration statement.
          
          (2)   That,  for  the purpose of determining any  liability
     under  the  Securities  Act, each such post-effective  amendment
     shall  be deemed to be a new registration statement relating  to
     the  securities  offered  therein,  and  the  offering  of  such
     securities  at that time shall be deemed to be the initial  bona
     fide offering thereof.
          
          (3)    To   remove  from  registration  by   means   of   a
     post-effective amendment any of the securities being  registered
     which remain unsold at the termination of the offering.
     
     (b)   Insofar  as indemnification for liabilities arising  under
the  Securities  Act  may  be permitted to  directors,  officers  and
controlling  persons  of  the registrant pursuant  to  the  foregoing
provisions, or otherwise, the registrant has been advised that in the
opinion  of  the  Commission such indemnification is  against  public
policy  as  expressed  in  the  Securities  Act  and  is,  therefore,
unenforceable.  In the event that a claim for indemnification against
such  liabilities  (other  than  the payment  by  the  registrant  of
expenses  incurred  or  paid by a director,  officer  or  controlling
person  of  the registrant in the successful defense of  any  action,
suit  or  proceeding)  is  asserted  by  such  director,  officer  or
controlling   person   in  connection  with  the   securities   being
registered, the registrant will, unless in the opinion of its counsel
the  matter  has been settled by controlling precedent, submit  to  a
court   of   appropriate  jurisdiction  the  question  whether   such
indemnification  by it is against public policy as expressed  in  the
Act and will be governed by the final adjudication of such issue.
<PAGE>                                  
                             SIGNATURES
     
     Pursuant to the requirements of the Securities Act of 1933,  the
Registrant  certifies that it has reasonable grounds to believe  that
it  meets all of the requirements for filing on Form S-3 and has duly
caused  this  Amendment  No. 1 to the Registration  Statement  to  be
signed  on  its behalf by the undersigned, thereunto duly authorized,
   
in the City of Albany, State of Oregon, on September 11, 1996.
                              
                          SYNTHETECH, INC.
                          
                          
                          
                          By:/s/ M. Sreenivasan
                           M. Sreenivasan
                           President and Chief Executive Officer
        
     Pursuant to the requirements of the Securities Act of 1933, this
Amendment  No.  1 to the Registration Statement has  been  signed  on
September  11,  1996  by  the  following persons  in  the  capacities
indicated:
                                                      
               Signature                            Title
                                        
         /s/ M. Sreenivasan             President, Chief Executive
             M. Sreenivasan             Officer and Director
                                        (Principal Executive Officer)
                                        
        /s/ Charles B. Williams         Vice President of Finance
            Charles B. Williams         and Administration, Chief
                                        Financial Officer, Secretary
                                        and Treasurer (Principal
                                        Financial Officer and
                                        Principal Accounting Officer)
                                        
          * Paul C. Ahrens              Chairman of the Board
            Paul C. Ahrens
                                        
                                       
          * Howard L. Farkas              Director
            Howard L. Farkas
                            
          * Page E. Golsan, III           Director
            Page E. Golsan, III
                                        
    *By /s/ Charles B. Williams
              Attorney-in-Fact
                                      
<PAGE>
   
                          INDEX TO EXHIBIT
                   TO AMENDMENT NO. 1 TO FORM S-3
                        FOR SYNTHETECH, INC.

        
Exhibit     Description
Number
        
5.1     Opinion of Perkins Coie regarding legality of the Common
        Stock being registered
        
23.1    Consent of Arthur Andersen LLP
        
23.2    Consent of Perkins Coie (included in the opinion filed
        as Exhibit 5.1)
        
*24.1   Power of Attorney

____________________

* Previously filed.
    

                                                                        
                                                          Exhibit 5.1
                                  
                         September 11, 1996


Synthetech, Inc.
1290 Industrial Way
Albany, Oregon  97321
     
     Re:  850,000 Shares of Common Stock ($.001 par value) of
          Synthetech, Inc. (the "Company")

Ladies and Gentlemen:
     
     We have acted as counsel to you in connection with the
preparation of a Registration Statement on Form S-3 (the
"Registration Statement"), File No. 333-8203 under the Securities Act
of 1933, as amended (the "Act"), with respect to 850,000 shares of
Common Stock, $.001 par value (the "Common Stock"), 750,000 of which
(the "Selling Shareholder Shares") may be sold from time to time by a
certain selling shareholder (the "Selling Shareholder") and 100,000 of
which (the "Company Shares") may be issued and sold from time to time
by the Company upon exercise of certain warrants (the "Warrants") to 
purchase Common Stock.  We have examined the Registration Statement and 
such documents and records of the Company as we have deemed necessary for 
the purpose of this opinion.
     
     Based upon and subject to the foregoing, we are of the opinion that:

     (i) the Company Shares have been validly authorized and when (a) the 
Warrants have been exercised and (b) such shares have been duly delivered
against payment therefor pursuant to the terms of the Warrants, such shares
will be validly issued, fully paid and nonassessable; and
 
     (ii) the Selling Shareholder Shares are duly authorized and are validly
issued, fully paid and nonassessable.
     
     We hereby consent to the filing of this opinion as Exhibit 5.1
to the Registration Statement.  In giving such consent, we do not
admit that we are in the category of persons whose consent is
required under Section 7 of the Act.  This opinion has been prepared
solely for your use in connection with the Registration Statement,
and should not be quoted in whole or in part or otherwise be referred
to, nor be relied upon by, nor be filed with or furnished to any
governmental agency or other person or entity, except as otherwise
provided in this paragraph, without the written consent of the firm.
                          
                          Very truly yours
                          
                          PERKINS COIE
    
                                                                     
                                                        
                                  
                                                     Exhibit 23.1
                                                      to Form S-3             
                                                               
                                                               
                                                               
                                  
              CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS
                                  
                                  
     
     As independent public accountants, we hereby consent to the
incorporation by reference in this Form S-3 registration statement,
registering up to 850,000 shares of common stock, of our report dated
May 16, 1996 included in Synthetech, Inc.'s Form 10-KSB for the year
ended March 31, 1996 and to all references to our firm included in
this registration statement.
     
     
     
                                        ARTHUR ANDERSEN LLP
     
     Portland, Oregon
        
     September 11, 1996
    


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