SYNTHETECH INC
10-K, 1998-06-26
INDUSTRIAL ORGANIC CHEMICALS
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<PAGE> i
       UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                               
                    Washington, D.C. 20549
                               
                           FORM 10-K
                               
                          (Mark One)
[X]  ANNUAL REPORT PURSUANT TO SECTION 13 or 15(d) OF THE
     SECURITIES EXCHANGE ACT OF 1934
     For the fiscal year ended March 31, 1998

[  ] TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE
     SECURITIES EXCHANGE ACT OF 1934
     For the transition period from __________ to __________
Commission file number 0-12992
                       SYNTHETECH, INC.
    (Exact name of registrant as specified in its charter)
                                                    
          Oregon                               84-0845771
     (State or other jurisdiction           (I.R.S. Employer
      of incorporation or organization)      Identification No.)             
                                                    
     1290 Industrial Way, Albany, Oregon         97321
     (Address  of  principal  executive        (Zip Code)
      offices)
                                                    
     Registrant's telephone number,       
      including area code:                   541/967-6575
                                                    
     Securities registered pursuant to           
      Section 12(b) of the Act:                  None
                                                      
     Securities registered pursuant to Section 12(g) of the Exchange Act:
                               
                      Common Stock, $.001 Par Value
                            (Title of class)
Indicate  by  check  mark  whether registrant  (1)  filed  all
reports  required to be filed by Section 13 or  15(d)  of  the
Securities Exchange Act of 1934 during the past 12 months  (or
for  such  shorter period that the registrant was required  to
file  such  reports), and (2) has been subject to such  filing
requirements for the past 90 days.   YES  X   NO

Indicate  by check mark if disclosure of delinquent filers  in
response to Item 405 of Regulation S-K is not contained herein
and  will  not  be  contained, to  the  best  of  registrant's
knowledge,  in  definitive  proxy  or  information  statements
incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K.  [   ]

As  of  May 22, 1998, the aggregate market value of the voting
stock   held   by   nonaffiliates  of   the   registrant   was
approximately $81 million based upon $7.38 per share.   Shares
of  Common Stock held by each officer and director and by each
person  who  owns  5% or more of the Common  Stock  have  been
excluded in that such persons may be deemed affiliates.   This
determination  of  affiliate  status  is  not  necessarily   a
conclusive determination for other purposes.

The  number  of  the  shares  of the  Company's  Common  Stock
outstanding on May 22, 1998 was 14,142,683.

<PAGE> ii
                               
                       Table of Contents

                                                                     Page
PART I

Item 1 - Business.................................................     1
Item 2 - Properties...............................................     9
Item 3 - Legal Proceedings........................................    10
Item 4 - Submission of Matters To a Vote of Security Holders......    10

PART II

Item 5 - Market Registrant's Common Stock and Related Shareholder
          Matters.................................................    10
Item 6 - Selected Financial Data..................................    11
Item 7 - Management's Discussion and Analysis of Financial 
          Condition and Results of Operations.....................    12
Item 7A- Quantitative and Qualitative Disclosure About Market Risk    18
Item 8 - Financial Statements and Supplementary Data..............    19
Item 9 - Changes In and Disagreements With Accountants on 
          Accounting and Financial Disclosure.....................    34

PART III

Item 10- Directors and Executive Officers of the Registrant.......    34
Item 11- Executive Compensation...................................    37
Item 12- Security Ownership of Certain Beneficial Owners and 
          Management..............................................    41
Item 13- Certain Relationships and Related Transactions...........    43

PART IV

Item 14- Exhibits, Financial Statement Schedules and Reports 
          on Form 8-K.............................................    43

Signatures........................................................    47



<PAGE> 1



                               
                            PART I
                               
                       ITEM 1.  BUSINESS

This  Annual Report contains forward-looking statements within
the  meaning of Section 21E of the Securities Exchange Act  of
1934, as amended.  Actual results could differ materially from
those  projected in the forward-looking statements  and  as  a
result  of the factors set forth in "Factors Affecting  Future
Results" and elsewhere in this Report.

GENERAL

Synthetech,  Inc.,  an Oregon corporation  (the  "Company"  or
"Synthetech"), produces Peptide Building Blocks  ("PBBs")  and
other  fine chemicals using a combination of organic chemistry
and biocatalysis.

MARKET OVERVIEW

The   market  for  PBBs  is  driven  by  the  market  for  the
synthetically   manufactured  peptides  in  which   they   are
incorporated.   The size of this market is a function  of  the
number of these peptides which are initially screened for  use
in  pharmaceuticals, the number of these pharmaceuticals which
progress  down  the path toward registration and,  ultimately,
the  number which are found to be therapeutically useful.  The
size  of  the market is also a function of the quantities  and
varieties  of PBBs necessary to produce these pharmaceuticals.
(See  "Industry  Factors" set forth in  Item  7,  Management's
Discussion and Analysis of Financial Condition and Results  of
Operations).

STRATEGY

Synthetech's  strategy is to emphasize  a  commitment  to  its
customers from the early phases of discovery through  clinical
development  in  order  to develop more  stable,  longer-term,
large-scale  orders as the drugs receive regulatory  approval.
The  receipt of two large-scale orders for marketed  drugs  in
fiscal  1998  exemplified  this  strategy.   The  Company  had
supplied  PBBs  for  both  of these drugs  since  their  early
clinical development stages.

PRODUCT OVERVIEW

Peptide  Building  Blocks.   Peptides  are  short  chains   of
generally  less than 50 amino acids and are used primarily  in
pharmaceuticals.   The production of peptides  requires  amino
acids  which have been chemically modified to enable  them  to
more  easily  link  with  other amino acids  in  a  particular
sequence  to form the desired peptide.  The Company refers  to
these  chemically  modified amino acids as  "Peptide  Building
Blocks" or "PBBs."  The amino acids which are transformed into
PBBs  may be either natural amino acids (that is, amino  acids
which  occur  in  nature) or synthetic amino acids  (that  is,
amino  acids  which have a side chain that does not  occur  in
nature),  which  the  Company refers to  as  "Specialty  Amino
Acids."

<PAGE> 2

Synthetech chemically modifies natural amino acids to  produce
PBBs.   The  Company also manufactures synthetic amino  acids,
and chemically modifies these synthetic amino acids to produce
PBBs.   The  Company  uses a wide array of  raw  materials  to
produce  PBBs.   These  materials generally  are  in  adequate
supply from multiple suppliers.

The Company has developed and scaled up process technology  to
produce a wide range of PBB products at the multi-kilogram  to
multi-ton  scale.  Since 1987, the Company has  produced  over
400 different PBB products.

Other  Fine  Chemicals.  The Company is capable  of  producing
other  fine chemical compounds.  These compounds have included
grignard reagents and other fine chemicals conforming  to  the
customer's confidential specifications. As the Company's  core
business  in  PBBs  expanded over the past  three  years,  the
Company  stopped  actively  marketing  these  products.    The
Company  has not produced nor received any revenue from  these
products  since fiscal 1996, when it sold $60,000 of  grignard
reagents  and  other  fine chemicals.  While  the  Company  is
establishing the additional processing facility to augment its
PBB processing capabilities, the Company might seek other fine
chemical  compounds and custom manufacturing opportunities  as
appropriate.
                               
                     _____________________

The  Company continues to produce most bulk orders on  an  as-
ordered basis, although it does carry an inventory of over 300
PBB products.  At March 31, 1998, the dollar amount of backlog
orders which the Company believed to be firm was approximately
$11.28  million,  all  of which the Company  expects  to  ship
during  fiscal  1999.   This backlog  included  $7.40  million
attributable to additional production in connection  with  two
large-scale  orders that the Company received in fiscal  1998.
The  backlog  at  March  31,  1997  was  $1.32  million.   The
variation  in  backlog  between  March  1998  and  March  1997
underscores  the continued variability in the demand  for  the
Company's  PBBs  at any given time (See Item 7,  "Management's
Discussion and Analysis of Financial Condition and Results  of
Operations").

In   January  1990,  the  Company  entered  into  supply   and
technology agreements with Biomeasure Incorporated,  a  Boston
area   biotechnology  company  and  a  subsidiary  of   Groupe
Pharmaceutique Beaufour-Ipsen of France with several synthetic
peptide   products  under  development.   Under   the   supply
agreement,   the  Company  has  agreed  to   supply   all   of
Biomeasure's  requirements  for a  particular  synthetic  PBB.
This  agreement continues from year to year unless  terminated
in  writing by one of the parties.  The Company and Biomeasure
are  also parties to a license agreement giving Biomeasure the
option to receive a license to produce for its own use the PBB
which  is  the  subject  of the supply agreement  between  the
parties.  Under  this license agreement, Biomeasure  must  pay
certain royalty amounts based on the amount produced.

<PAGE> 3

MARKETING

The  Company markets its products through attendance at  trade
shows,   listings  in  biotechnology  and  chemical   industry
directories  and advertisements in chemical trade periodicals.
In  addition, the Company maintains ongoing relationships with
major  pharmaceutical and other companies  which  it  believes
might have a need for its products.

CUSTOMERS

Although  the  Company  has over 250  customers,  the  Company
expects  that a few customers will continue to account  for  a
significant  portion  of revenues each  year.   During  fiscal
1998,  the  Company  had five customers  which  accounted  for
57%  of the Company's revenues.  The Company had two customers
which  individually accounted for over 10%  of  the  Company's
revenues.   These  two multinational pharmaceutical  companies
accounted  for 23% and 11%, respectively, of the  Synthetech's
revenues for fiscal 1998.

For  the  fiscal years ended March 31, 1998, 1997,  and  1996,
sales  to overseas customers were $2.85 million, $4.14 million
and  $1.78 million, respectively, accounting for approximately
34%,  32%,  and  21%,  respectively, of  the  Company's  total
revenues.   These sales were principally to Europe for  fiscal
1998, and to Europe and Japan for fiscal 1997 and 1996.

COMPETITION

Because peptide-based pharmaceuticals are relatively new,  the
market in the past for PBBs has been quite small -- with  most
sales  in the hundreds of kilos or smaller size.  As a result,
the  PBB  market  has  not attracted a significant  amount  of
direct  competition.   As the market continues  to  grow  with
multi-ton order sizes becoming more prevalent, the Company has
begun to see more competition.

Current  competition  in multi-kilo or smaller  quantities  of
natural  amino  acid based PBBs comes primarily  from  several
European  fine  chemical companies. Multi-ton order  sizes  of
these  natural  PBBs have begun to attract a  wider  group  of
domestic and international chemical companies.  In the area of
synthetic  amino acid based PBBs, the Company has  competition
on  a selective product basis from fine chemical producers  in
Europe  and Japan.  Competition  also increases for  supplying
PBBs  for  drug development programs that reach late  clinical
trials  and  move  into approved status as  a  result  of  the
increased  quantities typically required at these  stages  and
pharmaceutical company requirements to have second sources  of
material  available.  Many of the Company's  competitors  have
technical, financial, selling and other resources available to
them  which are significantly greater than those available  to
the Company.

The  principal methods of competition in the market  for  PBBs
and  other  fine chemicals are quality, customer  service  and
price.   The Company believes that it competes effectively  in
each  of  these  areas.  The Company also  believes  that  its
production of a wide range of products and quantities gives it
a competitive advantage in the marketplace.  In addition, the

<PAGE> 4

Company believes that pharmaceutical companies generally  view
internal  production of PBBs as a misallocation  of  resources
and,  given  a  reliable  source of a quality  product,  would
rather obtain them from an outside supplier.

RESEARCH AND DEVELOPMENT

The  Company's research and development efforts  have  focused
principally  on process development. During the  fiscal  years
ended  March 31, 1998, 1997, and 1996, the Company's  research
and   development  expenses  were  $215,000,   $211,000,   and
$217,000,  respectively.   These  figures,  however,  do   not
completely  reflect  the  Company's research  and  development
activity  since substantial process development  efforts  have
been  associated  with initial orders for  new  products  and,
accordingly,  have been expensed as cost of  sales  associated
with  the  product  revenue rather  than  as  a  research  and
development expense.  The Company estimates that its  combined
research  and  development effort (including  effort  directly
associated   with  the  sale  of  product)  was  approximately
$419,000, $346,000, and $364,000 during the fiscal years ended
March 31, 1998, 1997 and 1996, respectively.

EMPLOYEES

As  of May 22, 1998, the Company employed 43 individuals,  two
of whom were part-time.

REGULATORY MATTERS

As   the   Company's  products  are  intermediates   sold   to
pharmaceutical  producers,  the  Company  has  been  generally
unaffected  by  FDA  regulation which  is  directed  at  final
products  sold  to  the public.  The Company's  customers  do,
however,  typically  impose inspection and  quality  assurance
programs  on  the  Company.  These programs involve  materials
handling,  recordkeeping  and  other  requirements.  As   some
customers  have  begun  to  request  the  Company  to  provide
additional processing steps, these programs often include more
extensive  requirements.   The Company  anticipates  that  the
expenses of complying with such programs will increase in  the
future.

The   Company's  business  is  also  subject  to   substantial
regulation  in the areas of safety, environmental release  and
hazardous  waste disposal. Although the Company believes  that
it  is in compliance with these laws, rules and regulations in
all  material respects, the failure to comply with present  or
future regulations could result in fines being imposed on  the
Company,  suspension of production or cessation of operations.
As  additional and more extensive regulations are being  added
in  these  areas at the federal, state and local  levels,  the
compliance  costs will inevitably continue to  increase.   The
operation   of  chemical  manufacturing  plants  entails   the
inherent  risk of environmental damage or personal injury  due
to  the handling of potentially harmful substances, and  there
can  be no assurance that material costs and liabilities  will
not  be incurred in the future because of an accident or other
event  resulting in personal injury or an unauthorized release
of  such  substances to the environment.   Also,  the  Company
generates hazardous and other wastes which are disposed of  at
various off-site facilities. The

<PAGE> 5

Company  may  be liable, irrespective of fault,  for  material
cleanup  costs or other liabilities incurred at these disposal
facilities  due  to  releases  of  such  substances  into  the
environment.

The  Company  maintains property damage  insurance,  liability
insurance, environmental risk insurance, and product liability
insurance.

PRODUCT LIABILITY

Use  of  the  Company's  products in pharmaceuticals  and  the
subsequent testing, marketing and sale of such pharmaceuticals
involves an inherent risk of product liability.  There can  be
no  assurance that claims for product liability  will  not  be
asserted against the Company or that the Company would be able
to  successfully  defend any claim that may  be  asserted.   A
product  liability claim could have a material adverse  effect
on  the  business and/or financial condition of  the  Company.
The  Company  maintains  product liability  insurance  with  a
$1  million  limit.  Also, the Company maintains  an  umbrella
liability  insurance policy with an additional $4  million  of
coverage.

COMPANY BACKGROUND

The  Company  was  formed  in 1981 to develop  novel  chemical
process  technology by combining classical  organic  chemistry
with  enzyme-based biocatalysis.  For the first several years,
it operated mainly as a research and development group focused
on  process  development  of pharmaceuticals  and  other  fine
chemicals.   After its initial public offering  in  1984,  the
Company's   research   efforts  were   concentrated   on   the
development  of  a  proprietary process for aspartame  and  L-
phenylalanine.   Although the Company  had  entered  into  one
license  for  this  technology, the Company  does  not  expect
additional licensing revenue.

Throughout its development during the 1980s, the Company  also
offered  contract research services.  These research  services
were   typically  provided  to  pharmaceutical   clients   and
generally  involved the development of biocatalytic  processes
(that is, chemical processes which are affected by the use  of
enzymes  or  micro-organisms).  Since the end of fiscal  1990,
the Company has phased out contract research services and does
not anticipate receiving any significant revenue from research
services in the future.  By the end of the 1980s, the Company,
building  on  it  prior  experience, began  to  focus  on  the
production  of  PBBs and other fine chemicals  for  customers.
During  the  1990s,  the  Company has  emerged  as  a  leading
producer of PBBs in gram, multi-kilo and ton quantities.

FACTORS AFFECTING FUTURE RESULTS

This  Annual  Report  on  Form 10-K  includes  forward-looking
statements  (as  defined  in Section  21E  of  the  Securities
Exchange Act of 1934, as amended).  Forward-looking statements
include,  without limitation, any statement that may  predict,
forecast,  indicate  or imply future results,  performance  or
achievements,   and   may   contain   the   words   "believe,"
"anticipate,"  "expect,"  "estimate,"  "project,"  "will  be,"
"will  continue," "will likely result" or words or phrases  of
similar meanings. Investors are cautioned that forward-looking
statements

<PAGE> 6

involve  risks  and  uncertainties and various  factors  could
cause  actual  results to differ materially from the  forward-
looking  statements.   These risks and uncertainties  include,
but are not limited to, the following:
     
     Uncertain  Market  for Products; Customer  Concentration;
and  Potential  Quarterly Revenue Fluctuations.  Historically,
the  Company  has  experienced from time to  time  substantial
period-to-period revenue fluctuations reflecting the  industry
environment in which the Company has operated.  The market for
PBBs   is   driven   by  the  market  for  the   synthetically
manufactured   peptide-based  drugs  into   which   they   are
incorporated.  The drug development process is dictated by the
marketplace,  drug  companies and the regulatory  environment.
The Company has no control over the pace of peptide-based drug
development,  which  drugs get selected for  clinical  trials,
which  drugs  are approved by the Food and Drug Administration
("FDA"), and, even if approved, the ultimate potential of such
drugs.
     
     Recurring  sales of PBBs for discovery or clinical  trial
stage  development  programs is sporadic at  best.   The  high
cancellation rate for drug development programs results  in  a
significant  likelihood that there will be  no  subsequent  or
"follow-on"  PBB  sales  for any particular  drug  development
program.   Accordingly,  the  level  of  purchasing   by   the
Company's  customers  for specific drug  development  programs
varies  substantially from year to year and the Company cannot
rely on any one customer as a constant source of revenue.
     
     Sales  of  PBBs for marketed drugs provide an opportunity
for  continuing  longer-term sales and the  size  of  the  PBB
orders  for  marketed drugs can be substantially  larger  than
those  for the discovery or clinical trial stages.  While  not
subject  to the same high cancellation rate faced by discovery
and clinical trial stage drug development programs, the demand
for  the approved drugs remains subject to many uncertainties,
including, without limitation, the drug price, the  drug  side
effects  and  the existence of other competing  drugs.   These
factors, which are outside of the control of the Company, will
affect the level of demand for the drug itself and, therefore,
the demand for PBBs.
     
     Since the Company's revenues are composed of PBB sales in
all  three  drug development stages, and since even  sales  of
PBBs  for  marketed  drugs  are  subject  to  cancellation  or
reduction,  the  Company is likely to continue  to  experience
significant fluctuations in its quarterly results.
     
     Industry  Cost Factors.  The market for PBBs is dependent
on  the  market for pharmaceuticals products.  The  levels  of
revenues and profitability of pharmaceutical companies may  be
affected  by the continuing efforts of governmental and  third
party  payors  to contain or reduce the cost  of  health  care
through  various  means.   For  example,  in  certain  foreign
markets,    pricing   or   profitability    of    prescription
pharmaceuticals  is  subject to government  control.   In  the
United  States, there have been, and the Company expects  that
there  will  continue  to be, a number of  federal  and  state
proposals  to  implement  similar  government  controls.    In
addition,  in both the United States and elsewhere,  sales  of
prescription  pharmaceuticals are dependent  in  part  on  the
availability of reimbursement to the consumer from third party
payors such as government and private insurance plans.  Third

<PAGE> 7

party  payors are increasingly challenging the prices  charged
for  medical products and services.  Peptide-based  drugs  may
not be considered cost effective, and reimbursement may not be
available  or sufficient to allow peptide-based  drugs  to  be
sold on a profitable basis.  In addition, as cost pressures in
the  pharmaceutical industry have tightened, the  cancellation
rate  for  drug development programs has increased.   Industry
cost  pressures  can  also cause pharmaceutical  companies  to
investigate alternative drug manufacturing processes which may
not include PBBs.
     
     Competition.   In the past, the Company  has  not  had  a
significant  amount of direct competition  for  discovery  and
clinical  trial stage drug development projects.  The  Company
believes     that    this    resulted    from    peptide-based
pharmaceuticals,  particularly those which  utilize  synthetic
amino  acids,  being relatively new and the  market  for  PBBs
relatively  small.  As the market has continued to  grow  with
multi-ton order sizes becoming more prevalent, the Company has
begun  to  see more competition.  Current competition  in  the
multi-kilo  or smaller quantities of natural amino acid  based
PBBs  comes  primarily  from several  European  fine  chemical
companies.  Multi-ton order sizes of these natural  PBBs  have
begun  to  attract a wider group of domestic and international
chemical companies.  In the area of synthetic amino acid based
PBBs, the Company has competition on a selective product basis
from fine chemical producers in Europe and Japan.
     
     Competition  has  also increased for supplying  PBBs  for
drug development programs that reach late clinical trials  and
move  into  an  approved  status  as  a  result  of  increased
quantities   typically   required   at   these   stages    and
pharmaceutical company requirements to have second sources  of
material available.  The Company's competitors have technical,
financial, selling and other resources available to them  that
are significantly greater than those available to the Company.
     
     Regulatory Matters.  The Company is subject to a  variety
of  federal,  state  and  local laws,  rules  and  regulations
related  to  the discharge or disposal of toxic,  volatile  or
other hazardous chemicals.  Although the Company believes that
it  is in compliance with these laws, rules and regulations in
all  material respects, the failure to comply with present  or
future regulations could result in fines being imposed on  the
Company,  suspension of production or cessation of operations.
Third  parties  may  also have the right  to  sue  to  enforce
compliance.  Moreover, it is possible that increasingly strict
requirements  imposed  by environmental laws  and  enforcement
policies  thereunder  could  require  the  Company   to   make
significant capital expenditures.  The operation of a chemical
manufacturing plant entails the inherent risk of environmental
damage  or  personal injury due to the handling of potentially
harmful  substances,  and  there  can  be  no  assurance  that
material  costs  and liabilities will not be incurred  in  the
future  because  of  an accident or other event  resulting  in
personal injury or unauthorized release of such substances  to
the environment.  In addition, the Company generates hazardous
materials  and  other  wastes which are  disposed  at  various
offsite  facilities.  The Company may be liable,  irrespective
of  fault,  for  material cleanup costs or  other  liabilities
incurred  at  these  disposal facilities in  the  event  of  a
release  of hazardous substances by such facilities  into  the
environment.   The  Company  has obtained  environmental  risk
insurance.

<PAGE> 8
     
     Potential  Regulation.  The PBBs produced by the  Company
are  intermediate ingredients which are then processed by  the
companies  to which they are sold, and are therefore currently
not  subject  to the requirements of the FDA.   The  Company's
customers do, however, typically impose inspection and quality
assurance  programs  on the Company.  These  programs  involve
materials handling, record keeping and other requirements.  As
many  of  the  Company's  customers  are  requiring  increased
processing by the Company of its products, the Company expects
these  compliance  programs  to become  more  extensive.   The
Company  may  not  be  able  to  comply  with  the  applicable
requirements or such requirements may require the  expenditure
of significant capital.
     
     Product  Liability.   Use of the  Company's  products  in
pharmaceuticals and the subsequent testing, marketing and sale
of  such  pharmaceuticals involves an inherent risk of product
liability.   Claims  for product liability could  be  asserted
against  the  Company  and the Company  may  not  be  able  to
successfully defend any claim that may be asserted.  A product
liability  claim could have a material adverse effect  on  the
business  and/or  financial condition  of  the  Company.   The
Company has purchased product liability insurance with a limit
of  $1  million.   Also,  the Company  maintains  an  umbrella
liability  insurance policy with an additional $4  million  of
coverage.
     
     Risks  of  Technological  Change.   The  market  for  the
Company's products is characterized by rapid changes  in  both
product  and  process  technologies.   The  Company's   future
results  of operations will depend upon its ability to improve
and  market its existing products and to successfully develop,
manufacture and market new products.  The Company may  not  be
able  to  continue to improve and market its existing products
or   develop   and  market  new  products,  and  technological
developments could cause the Company's products and technology
to become obsolete or noncompetitive.
     
     Manufacturing Capacity.  As a manufacturer of  PBBs,  the
Company will continually face risks regarding the availability
and  costs of raw materials and labor, the potential need  for
additional  capital  equipment, increased  maintenance  costs,
plant  and  equipment obsolescence and quality  control.   The
Company  has  recently  completed an additional  manufacturing
facility  on its site in Albany, Oregon to increase production
capacity.   Initially, processing equipment was  installed  in
two  of  the  six  bays.  Recently the Company  announced  its
decision  to  install processing equipment in  two  additional
bays.  The Company expects that this additional phase will  be
completed in calendar 1999.  Completion of the second phase at
the  new facility could be delayed and the existing facilities
may  not  have sufficient capacity to meet the demand for  the
Company's products, particularly in the event that several  of
the  peptide-based drugs for which the Company  supplies  PBBs
simultaneously become commercially successful.   A  disruption
in  the  Company's  production or distribution  could  have  a
material  adverse  effect on the Company's financial  results.
In  addition,  the Company may not have sufficient  demand  to
utilize the additional capacity.
     
     Risks  of  International Business.   Sales  to  customers
outside the United States accounted for approximately  34%  of
the Company's net sales during the fiscal year ended March 31,
1998.   The  Company  expects that  international  sales  will
continue to account for a

<PAGE> 9

significant  percentage of net sales.  The Company's  business
is  and will be subject to the risks generally associated with
doing  business internationally, including changes  in  demand
resulting   from  fluctuations  in  exchange  rates,   foreign
governmental  regulation and changes in  economic  conditions.
These  factors,  among others, could influence  the  Company's
ability  to  sell its products in international  markets.   In
addition,  the  Company's business is  subject  to  the  risks
associated   with  legislation  and  regulation  relating   to
imports,  including quotas, duties or taxes and other charges,
restrictions  and  retaliatory actions  on  imports  to  other
countries  in  which the Company's products  may  be  sold  or
manufactured.
     
     Year  2000  Compliance.  The Company relies  on  computer
systems  and software to operate its business.  After  review,
the  Company believes that its software applications  will  be
able  to  appropriately interpret the calendar year  2000  and
subsequent  years after certain upgrades are completed  during
fiscal  1999.  The Company does not expect that  the  cost  of
these  upgrades will be material.  While the Company does  not
believe  it to be the case, there is a risk that the Company's
software   applications  will  be  unable   to   appropriately
interpret  such  years  despite  the  installation  of   these
upgrades.  Significant compliance costs or the failure by  the
Company  to  achieve full Year 2000 compliance  could  have  a
material  adverse  effect  on the  Company's  business  and/or
financial  condition.   In  addition,  the  Company  could  be
adversely affected by the failure of others, including without
limitation,  vendors, customers, transportation companies  and
utility companies, to become fully Year 2000 compliant.
                               
                               
                               
                      ITEM 2.  PROPERTIES

Synthetech's   headquarters  and  production  facilities   are
located in Albany, Oregon.  In 1987, the Company purchased the
Albany,  Oregon property which included a 23,000  square  foot
facility.   This  original facility houses  production,  pilot
plant,  laboratory, warehouse and office space.   In  November
1997,  the Company completed the construction of an additional
20,000  square foot production facility on the Albany,  Oregon
property.

The   completion  of  this  additional  two-story   production
facility  substantially increases the  Company's  capacity  to
produce PBBs and other fine chemicals.  This facility has  six
production   bays.   Two  of  the  bays  are  outfitted   with
manufacturing equipment and in production.  On May  28,  1998,
the  Company announced its decision to outfit two  more  bays.
The  final  two  bays remain vacant and available  for  future
expansion.

In  the initial construction of the building and the build out
of  the  first  two bays, Synthetech contracted  with  various
third party providers.  The Company issued purchase orders  to
such  providers with detailed specifications, services  to  be
provided  and  the  prices to be paid.  The  Company  received
either  limited or no written warranties by such  third  party
providers  and,  therefore, may be limited in its  ability  to
pursue  remedies  in  the  event that  the  new  building  has
problems  or  other  defects  in  the  future.   However,  the
building  has been inspected by the City of Albany  to  verify
that,  as constructed, it meets all applicable building codes,
including   ADA,  electrical,  seismic,  fire  and   hazardous
occupancy.  All specifications were reviewed by

<PAGE> 10

an  independent third-party engineering firm selected  by  the
City  of  Albany  prior  to approval of  various  construction
permits.


                               
                  ITEM 3.  LEGAL PROCEEDINGS

Not applicable.


                               
 ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

Not applicable.


                               
                            PART II
                               
       ITEM 5.  MARKET FOR REGISTRANT'S COMMON STOCK AND
                  RELATED SHAREHOLDER MATTERS

Commencing  on September 11, 1996, the Company's Common  Stock
began  trading on the Nasdaq National Market.  Prior  to  that
time,  the  Common  Stock was traded on  the  Nasdaq  SmallCap
Market.   The Company's common stock trading symbol is "NZYM."
The following table sets forth the range of high and low sales
prices  for  the  Common Stock for the  period  on  and  after
September 11, 1996 and the high and low bid quotations for the
Common  Stock prior to September 11, 1996, all as reported  by
Nasdaq.   The  bid  quotations  reflect  inter-dealer  prices,
without  retail  markup, markdown or commission  and  may  not
necessarily represent actual transactions.

<TABLE>
<CAPTION>
<S>                      <C>            <C>                <C>
<C>
                                  
                            Fiscal Year Ended March 31,
                      -----------------------------------------                
                            1998                  1997
                      -----------------   ---------------------             
                      High        Low        High          Low
                                               
     First Quarter    $9.38       $6.25    $10.75(1)    $5.81(1)
                                               
     Second Quarter    7.88        5.19      8.25(1)     6.38(1)
                                               
     Third Quarter     6.88        5.25     13.88        6.75
   
     Fourth Quarter    6.38        4.50     13.63        6.88
</TABLE>
___________________________

(1)bid quotation

<PAGE> 11

No  dividends  on the Company's Common Stock  have  been  paid
since  inception  and  the Company does  not  anticipate  that
dividends will be paid in the foreseeable future.  The  number
of  record  holders of Common Stock as of  May  22,  1998  was
approximately 709.
                               
                               
                               
               ITEM 6.  SELECTED FINANCIAL DATA

The  following statements of income data for each of the  five
years ended March 31, 1998 and the selected balance sheet data
as  of  March 31, 1994 through 1998, as set forth below,  were
derived  from  the Company's financial statements  audited  by
Arthur  Andersen LLP.  The following data should  be  read  in
conjunction   with   "Item   8.   Financial   Statements   And
Supplementary Data" and "Item 7.  Management's Discussion  and
Analysis  of  Financial Condition and Results  of  Operations"
included elsewhere herein.
<TABLE>
<CAPTION>
<S>                      <C>      <C>        <C>         <C>
<C>
                                          Year Ended March 31,
                                 1998    1997     1996     1995     1994
                                 ----    ----     ----     ----     ----
                                  (in thousands, except per share data)
                                           
  STATEMENTS OF INCOME DATA:
  Revenues                     $ 8,321  $12,797  $ 8,472  $ 5,357  $ 4,034
 
  Gross Profit                   3,001    7,694    4,787    2,759    2,078
  Operating Income               1,611    6,248    3,737    1,816    1,263
                                                        
  Net Income                   $ 1,221  $ 4,112  $ 2,574  $ 1,415  $ 1,164
                                                     
  Basic Net Income Per Share     $0.09    $0.30    $0.21    $0.12    $0.10
  Diluted Net Income Per Share   $0.09    $0.29    $0.19    $0.11    $0.09
 
                                                           
                                                           
                                                 March 31,
                                  1998    1997     1996      1995     1994
                                  ----    ----     ----      ----     ---- 
                                             (in thousands)
                                           
     BALANCE SHEET DATA:
     Working Capital           $ 8,237  $ 9,242  $ 8,157   $ 3,574  $ 4,124
                                                        
     Total Assets               19,364   17,323   10,959     6,661    5,574
     Long-Term Debt                166      180        -         -      370
     Retained Earnings
      (Accumulated Deficit)      8,931    7,710    3,598     1,024     (391)
     Shareholders' Equity      $17,306  $15,797  $10,100   $ 6,259  $ 4,773
</TABLE>

<PAGE> 12
                               
       ITEM 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF
         FINANCIAL CONDITION AND RESULTS OF OPERATIONS



RESULTS OF OPERATIONS

The following table sets forth, for the periods indicated, the
percentage  of revenues represented by each item  included  in
the Statements of Income.

<TABLE>
<CAPTION>                                                           
<S>                              <C>       <C>      <C>               
                                   Percentage of Revenues
                                 Fiscal Year Ended March 31,
                                                           
                                    1998     1997     1996
                                    ----     ----     ----              
Revenues                           100.0%   100.0%   100.0%
Cost of Sales                       63.9%    39.9%    43.5%
                                   ------   ------   ------
Gross Profit                        36.1%    60.1%    56.5%
                                                           
Research and Development             2.6%     1.6%     2.6%
Selling, general and                
 administrative                     14.1%     9.7%     9.8%
                                   ------   ------   ------
Operating Income                    19.4%    48.8%    44.1%
                                                           
Other Income                         3.7%     3.0%     3.4%
                                                       
Interest Expense                       -        -        -
                                   ------   ------   ------
Income Before Income Taxes          23.1%    51.8%    47.5%
                                                           
Provision for Income Taxes           8.4%    19.7%    17.1%
                                   ------   ------   ------
Net Income                          14.7%    32.1%    30.4%
                                   ======   ======   ======
</TABLE>

Revenues
- --------
Synthetech  revenues were $8.32 million,  $12.80  million  and
$8.47  million  in fiscal 1998, fiscal 1997 and  fiscal  1996,
respectively,  reflecting the unpredictability  and  potential
for  significant  revenue  fluctuations  associated  with  the
industry  environment  in which the  Company  operates.   (See
"Industry  Factors" below.)  The 35% decrease in  revenues  in
fiscal 1998 as compared to fiscal 1997 and the 51% increase in
revenues  in fiscal 1997 as compared to fiscal 1996  primarily
reflected  the  absence  or presence  of  large-scale  orders.
Revenues  from  large-scale orders were $2.17  million,  $8.07
million  and  $1.97 million for fiscal 1998, fiscal  1997  and
fiscal  1996, respectively.  The Company expects  that  fiscal
1999  revenues will be substantially larger than fiscal  1998.
At March 31, 1998, the Company had a backlog of PBB orders for
delivery  in fiscal 1999 of approximately $11.28 million.   Of
this  amount,  $7.40 million was attributable to the  unfilled
balance  of  the  two large-scale orders that it  received  in
fiscal 1998.

<PAGE> 13

While  the  Company  produces PBBs for a  number  of  approved
drugs, the two large-scale orders received in fiscal 1998 were
the  first large-scale PBB orders in the Company's history  to
be  received  for  use in marketed or "approved"  drugs.   The
revenue  received from large-scale orders in fiscal  1997  and
fiscal 1996 were associated with PBBs sold for use in clinical
trials.   PBB  sales associated with marketed drugs  are  much
more  likely to provide a longer term, ongoing revenue stream.
The  risk  that  drug production is cancelled is substantially
lower  after  it  is  being  actively  marketed.   Of  course,
continuation of customer demand for these PBBs remains subject
to  various  market  conditions,  including  continued  market
demand for the drug, competition from other suppliers of  PBBs
and potential use of alternative drug manufacturing routes not
involving PBBs.  (See "Industry Factors" below.)

The  two  large-scale orders received in fiscal 1998 exemplify
Synthetech's  long-term  growth  strategy  of  emphasizing   a
commitment to its customers from the early phases of discovery
through  clinical development in order to develop more stable,
longer-term large-scale orders as the drugs receive regulatory
approval.   The  Company had supplied PBBs for both  of  these
drugs since their early clinical development stages.

With  the  addition of sales from the two large-scale  orders,
the Company estimates that in fiscal 1998 approximately 46% of
the   Company's   PBB   sales  went   into   marketed   drugs,
approximately  41% went into drugs in clinical  or  late  pre-
clinical trials and approximately 13% went into drugs  at  the
R&D  or discovery stage.  With the unfilled balance of the two
large-scale orders aggregating $7.40 million at the  beginning
of  fiscal 1999, the Company expects the percentage of  fiscal
1999  sales of PBBs to be used in the marketed drug sector  to
be  equal  to  or higher than the fiscal 1998 percentage.   In
fiscal  1997, the Company estimates that approximately 11%  of
the   Company's   PBB   sales  went   into   marketed   drugs,
approximately  83% went into drugs in clinical  or  late  pre-
clinical  trials and approximately 6% went into drugs  at  the
R&D or discovery stage.  In fiscal 1996, the Company estimates
that  approximately 12% of the Company's PBB sales  went  into
marketed  drugs, approximately 80% went into drugs in clinical
or  late  pre-clinical trials and approximately 8%  went  into
drugs  at  the  R&D or discovery stage.  These  estimates  are
based on an analysis of the Company's sales and information to
the extent available from customers.

The  revenues during fiscal 1998, fiscal 1997 and fiscal  1996
represented sales of PBBs, the Company's primary product line,
except for $60,000 of sales in fiscal 1996 associated with the
sale of grignard reagents and other fine chemicals.

Gross Profit
- ------------
Gross   profit   was   $3.00  million,   $7.70   million   and
$4.79  million  in  fiscal 1998, 1997 and 1996,  respectively.
This  reflects a 61.0% decrease in gross profit in fiscal 1998
from  fiscal  1997, and a 60.7% increase in  gross  profit  in
fiscal  1997  from fiscal 1996.  As a percentage of  revenues,
gross profits were 36.1%, 60.1% and 56.5% in fiscal 1998, 1997
and 1996, respectively.

<PAGE> 14

Decreased  revenues  negatively affect gross  profit  margins.
Product  mix  (i.e.,  type  and  volume  of  product  sold  as
individual orders) can also significantly affect gross  profit
margins  either  positively or negatively.   The  decrease  in
gross  profit margin in fiscal 1998 from fiscal 1997 reflected
a  combination of factors:  the decline in revenues  resulting
from the absence of large-scale projects until the end of  the
third  quarter  of  fiscal  1998; the increased  manufacturing
overhead costs as the new plant facility came online in fiscal
1998;  costs  associated with the start up and  early  process
development at the new plant facility; and the product mix  in
fiscal  1998.   The Company anticipates that the gross  profit
margin  will  improve  in  fiscal 1999  with  the  anticipated
increase in revenues, although the Company expects to see some
reduction  in  this margin from fiscal 1996  and  fiscal  1997
levels reflecting a higher mix of larger-scale orders.

The  increase in the gross profit margin in fiscal  1997  from
fiscal  1996  resulted primarily from the increased  level  of
revenues and product mix.

The  Company  expects revenues and product mix to continue  to
fluctuate from period to period and cause variation  in  gross
profit margins.

Operating Expenses
- ------------------
Research  and development (R&D) expense increased to $215,000,
or  2.6%  of sales, in fiscal 1998, from $211,000, or 1.6%  of
sales, in fiscal 1997.  R&D expense was $217,000, or 2.6%,  in
fiscal  1996.   These  figures,  however,  do  not  completely
reflect the Company's research and development activity  since
substantial  process development efforts have been  associated
with  initial  orders for new products and, accordingly,  have
been  expensed  as cost of sales associated with  the  product
revenue  rather  than  as a research and development  expense.
The   Company   estimates  that  its  combined  research   and
development effort (including effort directly associated  with
the  sale of product) was approximately $419,000, $346,000 and
$364,000  during the fiscal years ended March 31,  1998,  1997
and 1996, respectively.

Selling,  general and administrative (SG&A) expense was  $1.18
million,  $1.24 million and $833,000 in fiscal 1998, 1997  and
1996, respectively.  The decrease in SG&A in fiscal 1998  from
fiscal  1997 primarily reflected the employee bonus  reduction
in  fiscal  1998 as the staffing level in this  area  remained
relatively constant.  The increase in SG&A in fiscal 1997 from
fiscal  1996 principally reflected the addition of  one  staff
employee,  base salary and bonus increases, and  increases  in
marketing, director and officer insurance and expenses related
to  the Company's move to the Nasdaq National Market.  SG&A as
a  percentage  of sales was 14.1%, 9.7%, and 9.8%  for  fiscal
1998, 1997 and 1996, respectively.

Operating Income
- ----------------
Operating  income  was  $1.61 million in  fiscal  1998,  $6.25
million  in fiscal 1997 and $3.74 million in fiscal 1996.   In
fiscal   1998,  Company-wide  labor  costs  (including  bonus)
(hereinafter  "labor costs") decreased to $1.50  million  from
$1.82  million  in  fiscal  1997.   While  the  Company  hired
additional employees during fiscal 1998 in connection with its
plant

<PAGE> 15

expansion,  the reduction in the level of bonuses paid  during
fiscal  1998 as compared to fiscal 1997 more than  offset  the
hiring increase, causing the net reduction in labor costs.  In
fiscal  1997,  labor costs increased nearly  23.9%  reflecting
compensation  increases  and  employee  additions  during  the
fiscal  year.   In  fiscal 1996, labor costs increased  28.9%.
Over  half  of  this increase was attributable to compensation
increases  and  the  remainder resulted from  an  increase  in
employee  hiring beginning in the second half of fiscal  1995.
As  a  percentage of revenues, operating income  decreased  to
19.4%  in fiscal 1998 compared to 48.8% in fiscal 1997 and  to
44.1%  in  fiscal 1996.  With the operating expense  level  in
fiscal  1998 and fiscal 1997 being relatively comparable,  the
decrease  in  operating margin in fiscal 1998 as  compared  to
fiscal  1997 principally reflected the decrease in  the  gross
profit margin discussed above.

Other Income
- ------------
The  $312,000  net  other  income  in  fiscal  1998  primarily
resulted  from  $294,000 of interest earnings  and  a  $25,000
recognized  gain  from  the sale of securities  available  for
sale.  The  $385,000 net other income in fiscal 1997 primarily
resulted from $376,000 of interest earnings. The $285,000  net
other  income in fiscal 1996 primarily resulted from  $242,000
of  interest  earnings and $43,000 of recognized gain  on  the
sale of securities available for sale.

Interest expense was $0 in fiscal 1998, $1,000 in fiscal  1997
and  $0  in  fiscal  1996.  Near the end of fiscal  1997,  the
Company  incurred  $194,000 in wastewater  system  development
charges assessed by the City of Albany in connection with  the
Company's  plant  expansion.  This fee plus  interest  on  the
unpaid  portion  is payable over the next ten  years.   During
fiscal  1998,  the  Company  paid  approximately  $17,000   of
interest  in connection with the unpaid portion of  this  fee.
This  payment was capitalized as part of the plant  expansion.
Beginning in fiscal 1999, the Company's interest payments will
be deducted as an interest expense.

Net Income
- ----------
In fiscal 1998, the Company earned $1.92 million before income
taxes.   A provision for income taxes of $702,000 resulted  in
net  income  of  $1.22 million.  In fiscal 1997,  the  Company
earned  $6.63  million before income taxes.  A  provision  for
income  taxes  of  $2.52 million resulted  in  net  income  of
$4.11  million.  The reduction in the effective  tax  rate  in
fiscal  1998  compared  to fiscal  1997  was  a  result  of  a
biennially  determined credit from the State  of  Oregon.   In
fiscal  1996,  the Company earned $4.02 million before  income
taxes.  A provision for income taxes of $1.45 million resulted
in  net  income  of $2.57 million.  The provision  for  income
taxes  in  fiscal  1996 was lower than fiscal  1997  primarily
because it included a biennially determined credit of $132,000
from the State of Oregon.

INDUSTRY FACTORS

The  market for PBBs is driven by the market for synthetically
manufactured   peptide-based   drugs   in   which   they   are
incorporated.  The drug development process for these peptide-
based drugs is dictated by the marketplace, drug companies and
the  regulatory environment.  The Company has no control  over
the pace of peptide-based drug development, which drugs get

<PAGE> 16

selected for clinical trials, which drugs are approved by  the
FDA  and,  even if approved, the ultimate market potential  of
such drugs.

The three stages of the drug development process include:  R&D
or  discovery  stage, clinical trial stage and  marketed  drug
stage.  Synthetech's customers can spend years researching and
developing  new  drugs,  taking only  a  small  percentage  to
clinical  trials  and  fewer  yet  to  commercial  market.   A
substantial amount of the activity continues to occur  at  the
earlier  stages  of  research  and  development  and  clinical
trials.   In  spite of the two large-scale orders received  by
the Company in fiscal 1998, the market for peptide-based drugs
is still very early in development.

While  the  Company has recorded substantial annual  sales  of
PBBs  for  discovery  and  clinical trial  stage  development,
recurring  sales of PBBs for development programs is  sporadic
at  best.   The  high cancellation rate for  drug  development
programs  results in a significant likelihood that there  will
be  no  subsequent or "follow-on" PBB sales for any particular
drug   development  program.   Accordingly,   the   level   of
purchasing  by  the  Company's  customers  for  specific  drug
development  programs  varies substantially  from  quarter  to
quarter and the Company cannot rely on any one customer  as  a
constant source of revenue.

While the Company has been selling PBBs for marketed drugs for
several  years,  these sales represented  a  relatively  small
portion  of  total  revenue.  With the two large-scale  orders
received in fiscal 1998 for PBBs to be used in marketed drugs,
revenues  of  PBBs for marketed drugs represent a  significant
portion  of total revenue for the first time in the  Company's
history.   Sales  of  PBBs  for  marketed  drugs  provide   an
opportunity  for continuing longer-term sales.  Moreover,  the
size of the PBB orders for marketed drugs can be substantially
larger  than those for the discovery or clinical trial stages.
While not subject to the same high cancellation rate faced  by
discovery  and clinical trial stage drug development programs,
the  demand  for  the approved drugs remains subject  to  many
uncertainties, including, without limitation, the drug  price,
the  drug  side  effects and the existence of other  competing
drugs.  These factors, which are outside of the control of the
Company,  will affect the level of demand for the drug  itself
and,  therefore, the demand for PBBs.  Also, with the  longer-
term,  larger-scale  orders,  the  Company  expects  increased
competition to supply these PBBs, and industry cost  pressures
can   also   cause  pharmaceutical  companies  to  investigate
alternative drug manufacturing processes which may not include
PBBs as an intermediate.

In the past, the Company has felt that it had neither a stable
baseload  of  demand nor an ability to predict  future  demand
beyond  its  current order base.  With the advent of  the  two
large-scale PBB orders for use in marketed drugs, the  Company
has  significantly  increased the size and  the  term  of  its
current order base.  Also, the likelihood of recurring revenue
from reorders is significantly higher for these two PBBs since
they  are  used  in marketed drugs.  Nevertheless,  since  the
Company's revenues are composed of PBB sales in all three drug
development stages, and since even sales of PBBs for  marketed
drugs are subject to cancellation or reduction, the Company is
likely  to continue to experience significant fluctuations  in
its quarterly results.

<PAGE> 17

LIQUIDITY AND CAPITAL RESOURCES

At  March  31,  1998,  the  Company  had  working  capital  of
$8.24 million compared to $9.24 million at March 31, 1997, and
$8.16  million at March 31, 1996. The Company's cash and  cash
equivalents  at  March 31, 1998 totaled  $4.98  million.   The
Company  no  longer holds securities available for sale  after
selling  its  last holding in fiscal 1998.  In  addition,  the
Company has a $1,000,000 unsecured bank line of credit.  As of
March 31, 1998 there was no amount outstanding under the  bank
line.

The  increase  in  accounts receivable  to  $1.47  million  at
March 31, 1998, from $695,000 at March 31, 1997, reflected the
higher level of revenues in the fourth quarter of fiscal  1998
compared  to  the  fourth  quarter in  the  prior  year.   The
increase of inventory to $3.18 million at March 31, 1998, from
$1.89  million  at  March  31, 1997, primarily  resulted  from
replenishing lower levels of raw material and finished product
inventory items and the build-up of raw materials and work-in-
process  related  to the two large-scale orders   received  in
fiscal  1998.  Inventory was $1.92 million at March 31,  1996.
The  decrease in accrued compensation to $221,000 at March 31,
1998, from $674,000 at March 31, 1997, primarily reflected the
payment in the first quarter of fiscal 1998 of bonuses accrued
for fiscal 1997.

In  November  1997,  the Company completed the  20,000  square
foot, two-story new building plant expansion project.  In this
initial  phase,  the Company completed the building  structure
and  built  out two of the six production bays.   The  overall
engineering, construction and equipment costs for this project
spanning  1 1/2 years  were  approximately  $8.23  million.   On
May  28,  1998,  the  Company  announced  that  its  Board  of
Directors had approved a $5 million second phase expansion  to
outfit  two  more  bays of the new plant with four  additional
multipurpose  reactor  systems.   The  Company  is   currently
operating  three production shifts, five days a week.   During
fiscal  1998,  the Company's capital costs were  approximately
$4.09  million,  $3.48 million of which  were  for  the  plant
expansion and $614,000 for the existing plant and equipment.

In  addition  to  the $5 million second-phase plant  expansion
described  above, the Company currently anticipates installing
up  to  $1  million  of additional capital  upgrades  for  the
original facility during fiscal 1999.  The Company expects  to
finance  these capital expenditures from operating  cash  flow
and  reserves and does not anticipate a need for any new  debt
or equity financing.

The  Company owns its facility and all of its equipment.   See
Note  D  to  Financial  Statements for a  description  of  the
Company's property, plant and equipment.

The  Company has assessed the impact  of the Year  2000  issue
and  has determined that costs to upgrade its information  and
operating systems are not expected to be material.

<PAGE> 18
                               
                               
                               
                               
                               
       ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURE
                       ABOUT MARKET RISK

Not applicable.

<PAGE> 19
                               
     ITEM 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA



                      Index                                     Page

Report of Independent Public Accountants for the years
ended March 31, 1998, 1997 and 1996........................       20

Financial Statements:

  Balance Sheets as of March 31, 1998 and
   1997...................................................        21

  Statements of Income for the years ended March 31,
   1998, 1997 and 1996....................................        23

  Statements of Shareholders' Equity for the years ended
   March 31, 1998, 1997 and 1996..........................        24

  Statements of Cash Flows for the years ended March 31,
   1998, 1997, and 1996...................................        25

Notes to Financial Statements:

  Note A - General and Business............................        26

  Note B - Summary of Significant Accounting Policies......        26

  Note C - Inventories.....................................        28

  Note D - Property, Plant and Equipment...................        28

  Note E - Income Taxes....................................        29

  Note F - Line of Credit..................................        29

  Note G - Note Payable....................................        30

  Note H - Shareholders' Equity............................        30

  Note I - 401(k) Profit Sharing Plan......................        33

  Note J - Segment Information.............................        33

<PAGE> 20

REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS

To  the  Board  of Directors and Shareholders  of  Synthetech, Inc.:

We have audited the accompanying balance sheets of Synthetech,
Inc.  (an  Oregon corporation) as of March 31, 1998 and  1997,
and the related statements of income, shareholders' equity and
cash  flows  for each of the three years in the  period  ended
March   31,   1998.   These  financial  statements   are   the
responsibility    of    the   Company's    management.     Our
responsibility  is  to express an opinion on  these  financial
statements based on our audits.

We  conducted our audits in accordance with generally accepted
auditing standards.  Those standards require that we plan  and
perform the audit to obtain reasonable assurance about whether
the  financial  statements are free of material  misstatement.
An  audit  includes  examining,  on  a  test  basis,  evidence
supporting  the  amounts  and  disclosures  in  the  financial
statements.   An audit also includes assessing the  accounting
principles  used and significant estimates made by management,
as   well   as  evaluating  the  overall  financial  statement
presentation.  We believe that our audits provide a reasonable
basis for our opinion.

In  our  opinion, the financial statements referred  to  above
present  fairly,  in  all  material  respects,  the  financial
position  of Synthetech, Inc. as of March 31, 1998  and  1997,
and  the results of its operations and its cash flows for each
of  the  three  years in the period ended March  31,  1998  in
conformity with generally accepted accounting principles.


Arthur Andersen LLP
Portland, Oregon,
May 14, 1998

<PAGE> 21

<TABLE>
<CAPTION>
<S>                                       <C>                 <C>
                                           SYNTHETECH, INC.          
                                                                       
                                            BALANCE SHEETS
                                            --------------
                                                                       
                                                                       
At  March 31                                     1998            1997
- ------------                                     ----            ----
                                                                       
 ASSETS                                                                
 ------                                                           
                                                                       
CURRENT ASSETS:                                                        
  Cash and cash equivalents                  $  4,976,000    $  6,740,000
  Securities available for sale                         -         176,000
  Accounts receivable, less allowance                                  
    for doubtful accounts of $15,000                                   
    for 1998 and 1997                           1,470,000         695,000
  Inventories                                   3,184,000       1,887,000
  Prepaid expenses                                196,000         164,000
  Income tax receivable                                 -         798,000
  Deferred income taxes                            70,000          56,000
  Other current assets                             24,000           4,000
                                              -----------     -----------
    TOTAL CURRENT ASSETS                        9,920,000      10,520,000
                                                                       
                                                                       
PROPERTY, PLANT AND EQUIPMENT, at cost, net     9,439,000       6,339,000
                                                                       
SECURITIES AVAILABLE FOR SALE                           -         450,000
                                                                       
OTHER ASSETS                                        5,000          14,000
                                              -----------     -----------
    TOTAL ASSETS                             $ 19,364,000    $ 17,323,000
                                             ============    ============
                   
                      See Notes To Financial Statements           
</TABLE>

<PAGE> 22

<TABLE>
<CAPTION>
<S>                                      <C>            <C>
                                             SYNTHETECH, INC.         
                                                                       
                                              BALANCE SHEETS
                                              --------------
                                                (continued)        
                                                                       
                                                                       
At March 31                                   1998            1997
- -----------                                   ----            ----
                                                                       
  LIABILITIES AND SHAREHOLDERS' EQUITY                                 
  ------------------------------------                                 
                                                                       
CURRENT LIABILITIES:                                                   
  Current portion of note payable          $     14,000    $     13,000
  Accounts payable                              672,000         543,000
  Accrued compensation                          221,000         674,000
  Deferred revenue                              247,000          44,000
  Accrued income tax                            514,000               -
  Other accrued liabilities                      15,000           4,000
                                            -----------     -----------
    TOTAL CURRENT LIABILITIES                 1,683,000       1,278,000
                                                                       
DEFERRED INCOME TAXES                           209,000          68,000
                                                                       
NOTE PAYABLE, net of current portion            166,000         180,000
                                                                       
SHAREHOLDERS' EQUITY:                                                  
  Common stock, $.001 par value;                                       
   authorized 100,000,000 shares; 
   issued and outstanding,
   14,143,000 and 13,860,000 shares              14,000          14,000
  Paid-in capital                             8,467,000       8,296,000
  Employee notes receivable and                                        
   deferred compensation                       (106,000)       (239,000)
  Unrealized gain on securities 
   available for sale                                 -          16,000 
  Retained earnings                           8,931,000       7,710,000
                                            -----------     -----------
    TOTAL SHAREHOLDERS' EQUITY               17,306,000      15,797,000
                                            -----------     -----------
    TOTAL LIABILITIES AND SHAREHOLDERS' 
     EQUITY                                $ 19,364,000    $ 17,323,000
                                           ============    ============
                                                                       
                          See Notes To Financial Statements.
</TABLE>

<PAGE> 23

<TABLE>
<CAPTION>
<S>                              <C>          <C>            <C>
                                              SYNTHETECH, INC. 
                                                    
                                            STATEMENTS OF INCOME
                                            --------------------               
             
For The Year Ended March 31          1998            1997           1996
- ---------------------------       -----------     -----------    ------------
                    
REVENUES                        $   8,321,000    $ 12,797,000   $   8,472,000
COST OF SALES                       5,320,000       5,103,000       3,685,000
                                -------------    ------------   -------------
GROSS PROFIT                        3,001,000       7,694,000       4,787,000
                                -------------    ------------   -------------
 
  Research and development            215,000         211,000         217,000
  Selling, general and 
   administrative                   1,175,000       1,235,000         833,000
                                -------------    ------------   -------------
OPERATING EXPENSE                   1,390,000       1,446,000       1,050,000
                                -------------     ------------   -------------

OPERATING INCOME                    1,611,000       6,248,000       3,737,000
                                  
OTHER INCOME                          312,000         385,000         285,000
INTEREST EXPENSE                            -           1,000               -
                                -------------    ------------   -------------

INCOME BEFORE INCOME TAXES          1,923,000       6,632,000       4,022,000
                                                           
PROVISION FOR INCOME TAXES            702,000       2,520,000       1,448,000
                                -------------    ------------   -------------
NET INCOME                      $   1,221,000   $   4,112,000   $   2,574,000
                                =============   =============   =============
                                                             
BASIC NET INCOME PER SHARE              $0.09           $0.30           $0.21
                                        =====           =====           =====
                                                     
DILUTED NET INCOME PER SHARE            $0.09           $0.29           $0.19
                                        =====           =====           =====
                                                                  
                     See Notes To Financial Statements.

</TABLE>

<PAGE> 24







<TABLE>
<CAPTION>
<S>                      <C>       <C>       <C>       <C>
                                       SYNTHETECH, INC.    
                                                
                               STATEMENTS OF SHAREHOLDERS' EQUITY
                               ----------------------------------
                                                  
                                                                                         UNREALIZED
                                                                              EMPLOYEE      GAIN
                                                                                NOTES     (LOSS) ON  
                                            COMMON STOCK                     RECEIVABLE   SECURITIES
                                          -----------------      PAID-IN     & DEFERRED   AVAILABLE   RETAINED
                                           SHARES    AMOUNT      CAPITAL    COMPENSATION   FOR SALE   EARNINGS
                                           ------    ------      -------    ------------  ---------- -----------
BALANCE, March 31, 1995                  12,054,000  $12,000   $5,196,000      $      -     $27,000   $1,024,000
Issuance of stock for the exercise of                                                                         
 stock options                              421,000        -      255,000             -           -            -
Issuance of stock for the exercise of                                                                          
 stock warrant                            1,000,000    1,000      992,000             -           -            -
Issuance of below-market stock options            -        -       70,000       (70,000)          -            -
Amortization of deferred compensation             -        -            -        20,000           -            -
Employee notes receivable                         -        -            -       (80,000)          -            -
Income tax benefit of disqualifying       
 dispositions                                     -        -       76,000             -           -            -
Unrealized gain on securities
 available for sale                               -        -            -             -       3,000            -   
Net income                                        -        -            -             -           -    2,574,000
                                         ----------   ------    ---------      ---------     ------    ---------   
BALANCE, March 31, 1996                  13,475,000   13,000    6,589,000      (130,000)     30,000    3,598,000
Issuance of stock for the exercise of                        
 stock options                              260,000    1,000      322,000             -           -            -
Issuance of stock for the exercise of            
 stock warrants                             125,000        -      228,000             -           -            -
Issuance of below-market stock options            -        -      284,000      (284,000)          -            - 
Amortization of deferred compensation             -        -            -       125,000           -            - 
Payment on employee note receivable               -        -            -        50,000           -            -
Income tax benefit of exercise of stock         
 warrants                                         -        -      216,000             -           -            -
Income tax benefit of disqualifying
 dispositions                                     -        -      657,000             -           -            -
Unrealized loss on securities            
 available for sale                               -        -            -             -     (14,000)           -
Net income                                        -        -            -             -           -    4,112,000
                                         ----------   ------    ---------      ---------     ------    ---------        
BALANCE, March 31, 1997                  13,860,000   14,000    8,296,000      (239,000)     16,000    7,710,000
Issuance of stock for the exercise of
 stock options                              283,000        -      280,000             -           -            -
Issuance of below-market stock options            -        -       21,000       (21,000)          -            -
Amortization of deferred compensation             -        -            -       124,000           -            -
Payment on employee note receivable               -        -            -        30,000           -            -
Revision on estimate ofincome tax                                                                               
 benefit on disqualifying dispositions            -        -     (207,000)            -           -            -
Income tax benefit of disqualifying 
 dispositions                                     -        -       40,000             -           -            -
Income tax benefit of non-qualified                                                                               
 option exercises                                 -        -       37,000             -           -            -
Realized gain on securities available
 for sale                                         -        -            -             -     (16,000)           -
Net income                                        -        -            -             -           -    1,221,000
                                         ----------  -------   ----------     ----------   ---------  ----------       
BALANCE, March 31, 1998                  14,143,000  $14,000   $8,467,000     ($106,000)    $     -   $8,931,000
                                         ==========  =======   ==========     ==========    ========  ==========

                                 See Notes To Financial Statements
                                                            

</TABLE>

<PAGE> 25

<TABLE>
<CAPTION>
<S>                                           <C>       <C>       <C>
                                              SYNTHETECH, INC.
          
                                          STATEMENTS OF CASH FLOWS
                                          ------------------------
                                   
For The Year Ended March 31                       1998       1997       1996
- ---------------------------                    --------   --------   -------
                                                        
CASH FLOWS FROM OPERATING ACTIVITIES:           
Net income                                   $ 1,221,000 $ 4,112,000 $ 2,574,000
Adjustments to reconcile net income to  
 net cash provided by (used by) operating      
 activities:
  Depreciation, amortization and other         1,009,000     268,000     205,000
  Amortization of deferred compensation          108,000     105,000      20,000
  Accrued interest on securities 
   available for sale                                  -       9,000      13,000
  Loss on disposal of property, plant and    
   equipment                                       5,000           -           -
  Realized gain on securities available 
   for sale                                      (25,000)    (10,000)    (43,000)
  Deferred income taxes                          127,000      61,000     (16,000)
  (Increase) decrease in assets:       
    Accounts receivable, net                    (775,000)    660,000    (515,000)
    Inventories                               (1,297,000)     37,000    (343,000)
    Prepaid expenses                             (32,000)    (93,000)    (17,000)
    Income tax receivable                        798,000    (646,000)   (152,000)
    Other assets                                 (20,000)     (1,000)      6,000
   Increase (decrease) in liabilities:       
    Accounts payable and accrued liabilities     201,000     470,000     355,000
    Deferred revenue                             203,000     (54,000)     98,000
                                              ----------   ---------   ---------
Net cash provided by operating activities      1,523,000   4,918,000   2,185,000
                                              ----------   ---------   ---------

CASH FLOWS FROM INVESTING ACTIVITIES:                   
 Property, plant and equipment purchases      (4,089,000) (5,079,000)   (461,000)
 Proceeds from sale of securities 
  available for sale and redemption of 
  securities available for sale                  635,000     380,000     882,000
 Employee notes receivable                        30,000      50,000     (80,000)
                                              ----------   ---------   ---------
Net cash provided by (used by) investing     
 activities                                   (3,424,000) (4,649,000)    341,000
                                              ----------- -----------  ----------
CASH FLOWS FROM FINANCING ACTIVITIES:                                               
 Principal payments under long-term debt                                          
  obligations                                    (13,000)     (1,000)          -
 Proceeds from stock option exercises and     
  disqualifying dispositions                     150,000     979,000     331,000
 Proceeds from stock warrant exercises, 
  including tax benefit                                -     444,000     993,000
                                              ----------  ----------   ----------
Net cash provided by financing activities        137,000   1,422,000   1,324,000
                                              ----------  ----------   ----------
NET INCREASE (DECREASE) IN CASH AND CASH 
 EQUIVALENTS                                  (1,764,000)  1,691,000   3,850,000
   
CASH AND CASH EQUIVALENTS AT BEGINNING 
 OF YEAR                                       6,740,000   5,049,000   1,199,000
                                              ----------  ----------   ----------
CASH AND CASH EQUIVALENTS AT END OF YEAR     $ 4,976,000 $ 6,740,000 $ 5,049,000
                                             =========== =========== ===========
NON-CASH INVESTING AND FINANCING ACTIVITIES:                                        
 Unrealized gain (loss) on securities  
  available for sale                                   -    ($14,000) $    3,000
 Issuance of stock options at below 
  fair value                                $     21,000 $   284,000  $   70,000
 Issuance of note payable for capital
  improvement                                          - $   194,000           -

                           See Notes To Financial Statements.
</TABLE>

<PAGE> 26


                       SYNTHETECH, INC.
                 NOTES TO FINANCIAL STATEMENTS
          
NOTE A.   GENERAL AND BUSINESS
          
          Synthetech,  Inc.,  an Oregon corporation,  produces
          specialty amino acids and other fine chemicals using
          a combination of organic chemistry and biocatalysis.
          The   Company's  primary  product  emphasis  is   on
          specialty   amino  acids  referred  to  as   Peptide
          Building  Blocks  which  are sold  domestically  and
          internationally  to  companies  developing  peptide-
          based pharmaceuticals.

NOTE B.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
          
          Use  of  Estimates:   The preparation  of  financial
          statements  in  conformity with  generally  accepted
          accounting  principles requires management  to  make
          estimates  and assumptions that affect the  reported
          amounts of assets and liabilities and disclosure  of
          contingent assets and liabilities at the date of the
          financial  statements and the  reported  amounts  of
          revenues  and expenses during the reporting  period.
          Actual results could differ from those estimates.
          
          Cash   and   Cash   Equivalents:   Cash   and   cash
          equivalents  include demand cash and all investments
          purchased with an original maturity of three  months
          or less.
          
          Securities  Available for Sale:  In  February  1998,
          the   Company  sold  the  last  of  its   securities
          available  for  sale.  Accordingly,  there  are   no
          securities available for sale as of March 31,  1998,
          and  all investments as of March 31, 1997 have  been
          reflected  as  securities available for  sale.   Any
          unrealized gains or losses have been reflected as  a
          separate   component  of  shareholders'  equity   in
          accordance with SFAS 115.
          
          At  March  31, 1997, securities available  for  sale
          consisted of government obligations which  were  due
          to   mature  during  1998  and  1999.   The  Company
          determined cost basis in its investments  using  the
          specific  identification method.  As  of  March  31,
          1997,  the difference between the fair market  value
          and   cost   of   the   Company's  investments   was
          insignificant.
          
          Property, Plant and Equipment:  Property, plant  and
          equipment  are  recorded at cost.  Depreciation  and
          amortization   are  provided  on  the  straight-line
          method  over seven to forty years for buildings  and
          land  improvements, and five to seven years  on  all
          other  property.  When property is sold or  retired,
          the  cost and accumulated depreciation reserves  are
          removed from the accounts and the resulting gain  or
          loss is included in income.
          
          Revenue   Recognition:   Sales   of   products   are
          recognized when products are shipped.
          
<PAGE> 27

NOTE B.   SUMMARY   OF  SIGNIFICANT  ACCOUNTING   POLICIES (CONTINUED)
          
          Research   and  Development  Costs:   Research   and
          development costs are expensed as incurred.
          
          Other  Assets:   Other  assets  primarily  represent
          patent  costs, which are amortized over  the  useful
          life of the patent.
          
          Earnings per Share: The Company adopted Statement of
          Financial Accounting Standards No. 128 "Earnings per
          Share" (SFAS 128) in the quarter ended December  31,
          1997.   Under  the  new  requirements,  the  Company
          reports basic and diluted earnings per share.  Basic
          earnings  per  share are computed  by  dividing  net
          income  by the weighted average number of shares  of
          common stock outstanding during the period.  Diluted
          earnings  per  share are computed  by  dividing  net
          income  by the weighted average number of shares  of
          common    stock   and   common   stock   equivalents
          outstanding during the period, calculated using  the
          treasury stock method as defined in SFAS 128.  Where
          necessary,  prior year amounts have  been  restated.
          The following is a reconciliation of the shares used
          to  calculate basic earnings per share  and  diluted
          earnings per share:
          
          <TABLE>
          <CAPTION>
          <S>                                   <C>        <C>     <C>
                                                 1998        1997       1996
                                                 ----        ----       ---- 
          Weighted average shares outstanding                       
           for basic EPS                       13,921,164  13,659,927 12,255,635
        
          Dilutive effect of Common stock                                    
           options and warrants issuable under 
           treasury stock method                  149,809     457,114  1,264,549
                                               ----------  ---------- ----------
          Weighted average common and common                        
           equivalent shares outstanding
           for diluted EPS                     14,070,973  14,117,041 13,520,184
                                               ==========  ========== ==========
          
          </TABLE>
          
          The following common stock equivalents were excluded from  the  
           earnings  per share  computation  because their effect would have 
           been anti-dilutive:
          
          <TABLE>
          <CAPTION>
          <S>                                   <C>        <C>       <C>
                                                    1998       1997     1996
                                                    ----       ----     ----
          Common stock options outstanding        482,300          -        -
          </TABLE>
<PAGE> 28
          
          

NOTE B.   SUMMARY   OF  SIGNIFICANT  ACCOUNTING   POLICIES (CONTINUED)

          Supplemental cash flow disclosures are as follows:
          
            Cash Paid During The Year For:
          <TABLE>
          <CAPTION>
          <S>                      <C>          <C>          <C>
                                       1998          1997         1996
                                       ----          ----         ----   
          Income Taxes               $419,000     $2,232,000   $1,586,000
          Interest                   $ 17,000     $    1,000   $        -

          </TABLE>
NOTE C.   INVENTORIES
          
          Inventories  are  stated at the  lower  of  cost  or
          market, determined on the first-in, first-out (FIFO)
          basis.  Cost utilized for inventory purposes include
          labor, material, and manufacturing overhead.
          
          The major components of inventories are as follows:
          <TABLE>
          <CAPTION>
          <S>                      <C>            <C>
                                                   
                                             March 31,
                                       1998             1997
                                       ----             ----
          Finished products         $1,009,000      $  779,000
          Work-in-process            1,033,000         440,000
          Raw materials              1,142,000         668,000
                                    ----------      ----------
                                    $3,184,000      $1,887,000
                                    ==========      ==========      
         </TABLE>
               
NOTE D.   PROPERTY, PLANT AND EQUIPMENT
          
          Property,  plant  and  equipment  consist   of   the
          following:
          <TABLE>
          <CAPTION>
          <S>                      <C>            <C>
                                                   
                                              March 31,
                                              ---------
                                         1998            1997
                                         ----            ----
          Land                       $    91,000      $    91,000
          Buildings                    4,340,000          658,000
          Machinery and equipment      6,277,000        1,561,000
          Laboratory equipment           338,000          286,000
          Furniture and fixtures         176,000          161,000
          Vehicles                        84,000           26,000
          Construction in progress       468,000        4,977,000
                                      ----------       ----------  
                                      11,774,000        7,760,000
          Less:                                      
          Accumulated depreciation     2,335,000        1,421,000
                                     -----------      ----------- 
                                     $ 9,439,000      $ 6,339,000
                                     ===========      ===========
         </TABLE>

<PAGE> 29

 NOTE E.  INCOME TAXES
          
          The  Company  accounts for income  taxes  under  the
          asset  and  liability  method  as  defined  by   the
          provisions  of  Statement  of  Financial  Accounting
          Standards No. 109 (SFAS 109), Accounting for  Income
          Taxes. Under this method, deferred income taxes  are
          recognized   for   the   future   tax   consequences
          attributable  to temporary differences  between  the
          financial   statement  carrying  amounts   and   tax
          balances   of   existing  assets  and   liabilities.
          Deferred  tax  assets and liabilities  are  measured
          using the enacted rates expected to apply to taxable
          income   in   the   years  which   those   temporary
          differences are expected to be recovered or settled.
          
          The  provision for income taxes in fiscal  1998  and
          fiscal  1997  included a deferred tax  provision  of
          $127,000  and $61,000, respectively.  The  provision
          for  income taxes in fiscal 1996 includes a deferred
          tax benefit of $16,000.
          
          Total  deferred tax assets and liabilities at  March
          31,  1998  were  $70,000 and $209,000, respectively.
          Individually   significant   differences    included
          book/tax   depreciation   differences   which   were
          recorded  as  a deferred tax liability of  $209,000.
          Total  deferred tax assets and liabilities at  March
          31,  1997,  were $56,000 and $68,000,  respectively.
          There  were  no  individually significant  temporary
          differences at March 31, 1997.
          
          The  reconciliation between the effective  tax  rate
          and  the  statutory federal income tax  rate  is  as
          follows:
          
          <TABLE>
          <CAPTION>
          <S>                            <C>       <C>        <C>       
                                          1998       1997       1996
                                          ----       ----       ----
          Statutory federal tax rate      34.0%      34.0%      34.0%
          State taxes                      2.5%       4.4%       2.0%
          Foreign sales corporation 
           benefit                        (1.5)%     (1.5)%        -
          Other                            1.5%       1.1%         -
                                          -----      -----      -----
          Effective tax rate              36.5%      38.0%      36.0%
                                          =====      =====      ===== 
         </TABLE>


NOTE  F.  LINE OF CREDIT
          
          The  Company has a line of credit available  with  a
          bank  in the amount of $1 million with an applicable
          interest rate of 8.5% at March 31, 1998.  There were
          no amounts outstanding under this loan at the end of
          the  fiscal year.  This line of credit is  renewable
          on an annual basis.
          
<PAGE> 30

NOTE G.   NOTE PAYABLE
          
          The  Company  entered into a note payable  with  the
          City  of  Albany  for payment of  wastewater  system
          development charges assessed in connection with  the
          Company's plant expansion.  The note bears  interest
          of 9.0% and is due in monthly installments of $2,459
          through February 2007.  The note is secured  by  the
          recently completed plant expansion building.
          
NOTE H.   SHAREHOLDERS' EQUITY

          On March 27, 1996, JB Partners exercised the warrant
          purchased  as  part of a stock and warrant  sale  in
          1991.    The   exercise   price   of   the   5-year,
          nontransferable warrant was $1.00 per share and  the
          net proceeds to the Company were $993,000.
          
          On  September  17  and  19, 1996,  the  Emanuel  and
          Company warrant authorized by the Board of Directors
          on  February  5, 1992 was exercised.   The  exercise
          price  of the 5-year warrant for 100,000 shares  was
          $2.22  per  share.  On December 19, 1996,  Mr.  Page
          Golsan, III exercised the warrant authorized by  the
          Board of Directors on January 7, 1992.  The exercise
          price  of  the 5-year warrant for 25,000 shares  was
          $1.81  per share.  The net proceeds of these warrant
          exercises was $228,000.  As of March 31, 1997, there
          were no stock warrants outstanding.
          
          During  1995,  the  Financial  Accounting  Standards
          Board  issued  SFAS 123 which defines a  fair  value
          based  method  of accounting for an  employee  stock
          option  or  similar equity instrument and encourages
          all  entities to adopt that method of accounting for
          all  of  their  employee stock  compensation  plans.
          However,  it  also allows an entity to  continue  to
          measure compensation cost for those plans using  the
          method of accounting prescribed in APB 25.  Entities
          electing  to remain with the accounting  in  APB  25
          must  make pro forma disclosures of net income  and,
          if  presented, earnings per share, as  if  the  fair
          value  based  method of accounting  defined  in  the
          Statement had been applied.
          
<PAGE> 31
          
NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)
          
          The  Company has elected to account for  its  stock-
          based compensation plan under APB 25.  However,  the
          Company  has  computed,  for  pro  forma  disclosure
          purposes,  the  value of all options granted  during
          fiscal  1998, fiscal 1997 and fiscal 1996 using  the
          Black-Scholes option-pricing model as prescribed  by
          SFAS  123,  using  the  following  weighted  average
          assumptions  for grants in fiscal 1998, fiscal  1997
          and fiscal 1996:
          <TABLE>
          <CAPTION>
          <S>                       <C>        <C>         <C>
          Fiscal Year                  1998        1997        1996
          -----------                  ----        ----        ----  
          Risk-free interest rate      6.49%       6.49%       6.26%
          Expected dividend yield         0%          0%          0%
          Expected life              3.60 years  3.89 years  3.89 years
          Expected volatility            57%       49-50%      49-67%
                                                            
          </TABLE>
          
          The  total  value of options granted  during  fiscal
          1998, fiscal 1997 and fiscal 1996 would be amortized
          on  a pro forma basis over the vesting period of the
          options.   Options generally vest equally  over  two
          years.   If  the  Company had  accounted  for  these
          options  in accordance with SFAS 123, the  Company's
          net  income  and  net income per  share  would  have
          decreased  as reflected in the following  pro  forma
          amounts:
          
          <TABLE>
          <CAPTION>
          <S>                      <C>       <C>       <C>
                                          Year ended March 31,
                                       1998        1997        1996
                                       ----        ----        ---- 
          Net income:                                       
           As reported              $1,221,000  $4,112,000  $2,574,000
           Pro forma                   214,000   3,461,000   2,390,000
          Basic net income per share:
           As reported                   $0.09       $0.30       $0.21
           Pro forma                     $0.02       $0.25       $0.20
          Diluted net income per share:
           As reported                   $0.09       $0.29       $0.19
           Pro Forma                     $0.02       $0.25       $0.18
          </TABLE>
          Using the Black-Scholes methodology, the total value
          of  options granted during fiscal 1998, fiscal  1997
          and   fiscal  1996  was  $873,000,  $1,375,000   and
          $465,000,  respectively, which would be amortized on
          a  pro  forma basis over the vesting period  of  the
          options (generally two years).  The weighted average
          fair  value  of options granted during fiscal  1998,
          fiscal  1997  and fiscal 1996 was $3.45,  $4.17  and
          $1.73, respectively.
          
<PAGE> 32
          
          
          
          
NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)
          
          Under  the  Amended and Restated 1990  Stock  Option
          Plan  1,600,000 shares were authorized for issuance.
          A total of 1,491,160 options were granted under this
          plan.   A  total  of  1,233,950  options  have  been
          exercised and 55,110 options have been cancelled  as
          of   March  31,  1998  under  the  plan  since   its
          inception.  The options granted under this plan vest
          over  a  two year period from the beginning  of  the
          fiscal year in which the options are granted  and  a
          maximum term of 5 years.
          
          The  1995  Incentive  Compensation  Plan  authorized
          902,000  shares of the Company's stock to be issued.
          This  plan  is  the  successor to  the  Amended  and
          Restated 1990 Stock Option Plan.  No further  grants
          will  be  made under the original plan.  A total  of
          602,000  options have been granted under this  plan.
          A  total  of  7,000 options have been exercised  and
          47,700  options have been cancelled as of March  31,
          1998 under the plan since its inception. The options
          granted  under this plan generally vest over  a  two
          year period from the beginning of the fiscal year in
          which the options are granted.  However, to a lesser
          extent, some options vest from 50% after one year of
          employment and 100% after 2 years of employment, and
          some options vest in less than a year and others  up
          to  five years. Options granted under this plan have
          a  maximum  term  of 10 years.  The  1995  Incentive
          Compensation  Plan was amended in November  1996  to
          permit   granting   of  non-qualified   options   to
          directors who are not employees of the Company.


          Activity  under the Amended and Restated 1990  Stock
          Option  Plan  and 1995 Incentive Compensation  Plans
          over  the  last  two fiscal years is  summarized  as
          follows:
          <TABLE>
          <CAPTION>
          <S>                <C>         <C>          <C>       <C>
   Year ended March 31,              1998                   1997
   --------------------        --------------------  ---------------------     
                                         Wtd. Avg.              Wtd. Avg.
                                 Shares  Ex. Price      Shares  Ex. Price
                                -------  ---------      ------  ---------
Options outstanding at                        
 beginning of year              913,810    $4.06        871,960   $2.02
Granted                         253,000    $7.05        330,000   $7.40
Exercised                      (373,710)   $2.04       (275,950)  $1.58
Cancelled                       (43,700)   $8.02        (12,200)  $4.70
                               ---------   -----       ---------  -----
Options outstanding at
 end of year                    749,400    $5.85        913,810   $4.06
                               ========    =====       ========   =====
  
Exercisable at end
 of year                        381,183    $4.48        484,010   $2.08

Weighted average fair value
 of options granted at market
 value                                -    $3.41              -   $3.78

Weighted average fair value
 of options granted at below
 market value                         -    $7.02              -   $5.86

</TABLE>

<PAGE> 33
          
          
NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)
          
          
          The  following  table sets forth the exercise  price
          range,  number of shares outstanding  at  March  31,
          1998,  weighted average remaining contractual  life,
          weighted   average   exercise   price,   number   of
          exercisable  shares  and weighted  average  exercise
          price  of  exercisable options by groups of  similar
          price and grant date:
<TABLE>
<CAPTION>
<S><C>            <C>            <C>         <C>        <C>       <C>
                        Options Outstanding           Options Exercisable
                ----------------------------------- -----------------------
                              Wtd. Avg.                               
Exercise        Outstanding   Remaining   Wtd. Avg.              Wtd. Avg.
Price             Shares     Contractual  Exercise  Exercisable  Exercise
Range            at 3/31/98  Life (Years)   Price     Options      Price
- --------        -----------  ------------ --------- -----------  ----------

$0.30-$0.51          15,000      7.90       $0.49         12,000    $0.42
$1.72-$1.81          50,000      8.58       $1.81         33,333    $1.81
$2.22-$2.84         202,100      1.11       $2.67        202,100    $2.67
$7.13-$8.50         482,300      8.76       $7.77        133,750    $8.25
</TABLE>
          
          
NOTE I.            401(k) PROFIT SHARING PLAN
          
          The Company established a 401(k) Profit Sharing Plan
          on  April 1, 1992.  This plan is offered to eligible
          employees, who may elect to contribute up to 15%  of
          compensation   and   includes  a  Company   matching
          contribution.  Beginning in April 1996, the  Company
          amended the plan to change the matching contribution
          to  $.50,  $.75 and $1.00 for each $1.00 contributed
          up to 10% of compensation corresponding to length of
          service  with the Company.  Prior to this  amendment
          the  Company matching contribution was $.50 for each
          $1.00  contributed by each employee  up  to  10%  of
          compensation. The Company contribution becomes fully
          vested   for   each  employee  after  5   years   of
          employment.   The Company matching contribution  for
          fiscal  years  1998,  1997, and  1996  was  $46,000,
          $77,000 and $42,000, respectively.
          
NOTE J.   SEGMENT INFORMATION
          
          Significant Customers:  During fiscal year 1998, two
          customers accounted for 23% and 11% of revenues.
          During fiscal year 1997, two customers accounted for
          30% and 29% of revenues.  During fiscal year 1996,
          two customers accounted for 23% and 11% of revenues.

          The  following  table  reflects  foreign  sales  and
          percent of total sales by country:
          <TABLE>
          <CAPTION>
          <S>      <C>         <C>     <C>          <C>     <C>          <C>
                                                                
                           1998               1997                 1996
                    -----------------   ------------------   -----------------
          Europe    $2,606,000  31.3%   $1,262,000    9.9%   $1,252,000  14.8%
          Japan     $  205,000   2.5%   $2,880,000   22.5%   $  528,000   6.2%

          </TABLE>
<PAGE> 34
                                
     ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS
             ON ACCOUNTING AND FINANCIAL DISCLOSURE


Not applicable.

                                
                            PART III
                                
        ITEM 10.  DIRECTORS AND EXECUTIVE OFFICERS OF THE
                           REGISTRANT

The following table sets forth certain information concerning the
executive officers and directors of the Company:

<TABLE>
<CAPTION>
<S>  <C>                     <C>        <C>
             Name                Age                Position
             ----                ---                --------
     M. ("Sreeni") Sreenivasan    49       President, Chief Executive
                                           Officer and Director

     Philip L. Knutson*           48       Vice President of Research
                                           and Development

     Charles B. Williams          51       Vice President of Finance
                                           and Administration, Chief
                                           Financial Officer,
                                           Secretary and Treasurer and
                                           Director

     Jay A. Bouwens               52       Vice President of
                                           Manufacturing

     Paul C. Ahrens               46       Chairman of the Board

     Howard L. Farkas             74       Director

     Edward M. Giles              62       Director

     Page E. Golsan, III          60       Director

     Donald E. Kuhla, Ph.D.       55       Director
</TABLE>
    _______________
    
    *   Dr.  Knutson  resigned  his  position  with  the  Company
    effective May 8, 1998.

The  following  is a brief account of the business experience  of
each executive officer and director of the Company.

M. "Sreeni" Sreenivasan.  Mr. Sreenivasan has served as President
and  Chief  Executive Officer since March 31, 1995 and  as  Chief
Operating  Officer  from  1990  through  March  31,  1995.    Mr.
Sreenivasan has also served as a director since 1995.  From  1988
to  1990 he was Executive Vice President and General Manager  and
from  1987 to 1988 he was director of Manufacturing.  Previously,
he  worked  for Ruetgers-Nease Chemical Co. (bulk pharmaceuticals
and  other fine chemicals) for 13 years in various technical  and
manufacturing management capacities, including 7 years  as  Plant
Manager   of  their  Augusta,  Georgia  plant.   Mr.  Sreenivasan
received   his   M.S.  in  Chemical  Engineering  from   Bucknell
University and his M.B.A. from Penn State University.

<PAGE> 35

Philip L. Knutson, Ph.D.  Dr. Knutson resigned his position  with
the Company effective May 8, 1998 after serving as Vice President
of   Research  and  Development  since  1988.   Dr.  Knutson  was
responsible  for process development, "kilo lab"  production  and
production support.  From 1986 to 1988, he was a Senior  Research
Chemist  with  the  Company.  Prior thereto, Dr.  Knutson  was  a
Senior Research Chemist at Ash Stevens, Inc. in Detroit, Michigan
for  7  years.  He received his B.A. degree from Luther  College,
Decorah,  Iowa  and his M.A. and Ph.D. in Organic Chemistry  from
the University of Missouri - Columbia.

Charles  B. Williams.  Mr. Williams has served as Vice  President
of Finance and Administration and Treasurer since 1990.  In 1995,
he  became the Secretary of the Company and in July 1995, he also
became Chief Financial Officer.  Mr. Williams has also served  as
a  director  since July, 1997.  Mr. Williams is  responsible  for
accounting,  administration, finance, personnel  and  information
systems.   From  1988  to  1990,  Mr.  Williams  served  as   the
Controller.   Prior  thereto,  he  was  Controller  for   White's
Electronics,  Inc.  of  Sweet Home,  Oregon  for  5  years.   His
responsibilities at White's Electronics included accounting, data
processing,  personnel and finance. From 1976 to  1983,  he  held
several  accounting  and financial positions  with  Teledyne  Wah
Chang,  a metals producer in Albany, Oregon.  Mr. Williams earned
his B.S. in Economics and M.B.A. from Oregon State University.

Jay  A.  Bouwens.   Mr. Bouwens has served as Vice  President  of
Manufacturing since 1996. From 1994 to 1996, he was  director  of
Manufacturing with the Company.  From 1992 to 1994,  Mr.  Bouwens
was  the  Pilot  Plant Manager at Ash Stevens, Inc.  in  Detroit,
Michigan.  From 1990 to 1992 he was Production Manager  for  Poly
Organix in Newburyport, Massachusetts.  From 1967 to 1990 he held
various   chemical  manufacturing  positions,  including  Process
Manager for Wyeth-Ayerst laboratories in Rouses Point, New  York.
Mr. Bouwens received his B.S. in Chemistry from the University of
Michigan.

Paul  C.  Ahrens.  Mr. Ahrens has been a director of the  Company
since  its  inception in 1981 and became Chairman  of  the  Board
effective  March 31, 1995.  Since 1996, he has been  the  founder
and  President  of  Groovie  Moovies,  Ltd.,  a  film  production
company.   Mr.  Ahrens,  a  founder of  the  Company,  served  as
President  and  Chief Executive Officer of Synthetech  from  1989
through  March  1995.  From 1981 through 1989  he  was  the  Vice
President  of  Technology.  He also served as  Secretary  of  the
Company  from 1981 through 1995.  From 1979 to 1980,  Mr.  Ahrens
served  as  Vice  President of Engineering  of  Colorado  Organic
Chemical  Company,  an  organic  chemical  manufacturing  company
located  in  Commerce City, Colorado.  Prior thereto, Mr.  Ahrens
spent  five years with Allied Chemical and CIBA-Geigy in  various
engineering and research capacities.  Mr. Ahrens holds  B.S.  and
M.S. degrees in Chemical Engineering from M.I.T.

Howard  L.  Farkas.  Mr. Farkas has served as a director  of  the
Company  since  1985.  Since 1981, he has been the  President  of
Farkas  Group,  Inc.,  and since 1992 he has  been  President  of
Windsor  Gardens  Realty,  Inc., both of  which  are  engaged  in
general  real estate brokerage and management activities.    From
1984  to 1996, he was also the managing director in Manistee  Gas
Limited  Liability  Company, which is in the gas  production  and
processing  business.  Mr.  Farkas  serves  as  Secretary  and  a
director  of  Acquisition  Industries,  Inc.,  a  publicly  owned
acquisition  and  merger  company.   Mr.  Farkas  serves  as  the
Chairman  of  the  Board  of Logic Devices,  Inc.,  a  Sunnyvale,
California  company specializing in CMOS digital  signal  process
semiconductor and SRAM chips.

<PAGE> 36

Since  May  1988,  Mr. Farkas has also been a vice  president  of
G.A.S.  Corp., which is a general partner of an Oklahoma  limited
partnership, Gas Acquisition Services, which filed for bankruptcy
under  Chapter  11.   In  September 1992, Mr.  Farkas  filed  for
personal  protection  under Chapter 7 of the  federal  bankruptcy
laws and the court subsequently entered an order discharging  his
debts.   Though not presently in public or private  practice,  he
has  been  a  certified public accountant since 1951. Mr.  Farkas
received a B.S. (B.A.) from the University of Denver.

Edward M. Giles.  Mr. Giles has served as a director since  July,
1997.   Mr.  Giles  has served as Chairman and President  of  The
Vertical  Group, Inc., a venture capital investment  firm,  since
January 1989.  Mr. Giles was previously President of F. Eberstadt
&  Co.,  Inc., a securities firm, and Vice Chairman of  Peter  B.
Cannell  &  Co.,  Inc.,  an investment management  firm.   He  is
currently a director of McWhorter Technologies, Inc. and  Ventana
Medical Systems, Inc.  Mr. Giles received a B.S.Ch.E. in Chemical
Engineering  from Princeton University and an M.S. in  Industrial
Management from the Massachusetts Institute of Technology.

Page E. Golsan, III.  Mr. Golsan has served as a director of  the
Company since 1991.  Since 1986, he has been a principal of  P.E.
Golsan  &  Co.  (formerly Golsan Management Company),  a  private
capital  management firm.  From 1990 to 1992, Mr.  Golsan  was  a
senior advisor with Bane Barham & Holloway, registered investment
advisors  under the Investment Advisor Act of 1940.   Since  1990
Mr.  Golsan  has  been President and Chief Executive  Officer  of
Bridgetown  Capital, Inc., an investment company.  From  1987  to
1989  he  was the Executive Vice President of Calumet Industries,
Inc.,  Chicago,  Illinois (manufacturer and  marketer  of  petro-
chemicals and other fine chemicals).  Prior to 1987, he  was  the
President  and  Chief  Operating  Officer  of  the  K&W  Products
Division   (specialty   chemical  manufacturing)   of   Berkshire
Hathaway, Inc. Mr. Golsan holds an M.A. in Finance from Claremont
Graduate  School of Business and a Doctorate in  Pharmacy  and  a
B.A.  in  Chemistry  and  Zoology, both from  the  University  of
Southern California.

Donald E. Kuhla, Ph.D.  Dr. Kuhla has served as a director  since
July,  1997.   Since 1994, he has been Vice President  and  Chief
Technical  Officer of Plexus Ventures, Inc., a biotech consulting
and  investment firm.   From 1990 to 1994, Dr. Kuhla held  senior
management   positions   with   two   venture   capital   backed,
biotechnology start-up companies.  Previously, he was in research
and  development and operations management positions with  Pfizer
Inc.  and  Rorer  Group, Inc., his last position at  Rorer  being
Senior Vice President of Operations.  Dr. Kuhla is a director  of
NPS  Pharmaceuticals, Inc. (a biotechnology  drug  discovery  and
development  company).  Dr. Kuhla received a  B.A.  in  Chemistry
from  New  York University and a Ph.D. in Organic Chemistry  from
Ohio State University.



Schedule 16(a) Beneficial Ownership Reporting Compliance
- --------------------------------------------------------
Section 16(a) of the Securities Exchange Act of 1934, as amended,
requires  the Company's officers and directors, and  persons  who
own  more than 10% of a registered class of the Company's  equity
securities, to file reports of ownership on Form 3 and changes in
ownership  on  Form 4 or Form 5 with the Securities and  Exchange
Commission ("SEC").  Such officers,

<PAGE> 37

directors and 10% shareholders are also required by SEC rules  to
furnish  the Company with copies of all Section 16(a) forms  they
file.

Based  solely on its review of the copies of such forms  received
by it, or written representations from certain reporting persons,
the Company believes that, during the fiscal year ended March 31,
1998,  all  Section 16(a) filing requirements applicable  to  its
officers,  directors  and 10% shareholders  were  complied  with,
except  for  the  following late filings:  one Form  4  filed  by
Mr.  Ahrens with regard to one transaction, one Form 4  filed  by
Mr.  Sreenivasan with regard to one transaction and  one  Form  4
filed by Mr. Williams with regard to one transaction.
                                
                                
                                
                ITEM 11.  EXECUTIVE COMPENSATION

REPORT OF THE COMPENSATION COMMITTEE

The  Compensation  Committee sets, reviews  and  administers  the
executive compensation program of the Company and is comprised of
the  individuals  noted  below, each  of  whom  are  non-employee
directors of the Company.  The role of the Compensation Committee
is  to establish and approve salaries and other compensation paid
to  the  executive officers of the Company and to administer  the
Company's  stock option plan, in which capacity the  Compensation
Committee  reviews  and  approves  stock  option  grants  to  all
employees.

Compensation Philosophy.  Synthetech's compensation philosophy is
that  cash  compensation should be directly linked to the  short-
term  performance of the Company and that longer-term incentives,
such  as  stock options, should be aligned with the objective  of
enhancing shareholder value over the long term. The use of  stock
options clearly links the interests of the officers and employees
of  the  Company  to  the  interests  of  the  shareholders.   In
addition,  the  Compensation Committee believes  that  the  total
compensation package must be competitive with other companies  in
the  industry to ensure that the Company can continue to attract,
retain  and motivate key employees who are critical to the  long-
term success of the Company.

Components  of Executive Compensation.  The principal  components
of  executive  compensation are base salary,  bonuses  and  stock
options.

Base  salary is set based on competitive factors and the historic
salary structure for various levels of responsibility within  the
Company.  In addition, the Company relies on bonuses in order  to
emphasize the importance of performance.

The  equity  component  of executive compensation  is  the  stock
option  program.  Stock  options are generally  granted  when  an
executive  joins the Company and, typically, on an  annual  basis
thereafter.   The options granted to the executives vest  over  a
period of two years.  The purpose of the annual option grants  is
to  ensure  that the executive always has options  that  vest  in
increments  over the following two-year period.  This provides  a
method   of  retention  and  motivation  for  the  senior   level
executives  of  the  Company and also aligns senior  management's
objectives with long-term stock price appreciation.

<PAGE> 38

Other elements of executive compensation are participation  in  a
Company-wide  life  insurance,  long-term  disability  insurance,
medical benefits and ability to defer compensation pursuant to  a
401(k)  plan.  Matching Company contributions to the 401(k)  plan
of up to 10% of eligible base pay were made in fiscal 1998.

As  a  result  of the decline in revenues and profits  in  fiscal
1998,  the  Compensation Committee did not grant bonuses  to  Mr.
Sreenivasan,  the  CEO, or any of the other  executive  officers.
Consistent with its policy to create longer-term incentives,  the
Compensation  Committee granted stock options  to  the  executive
officers, including a 25,000 share option to Mr. Sreenivasan.
                              
                              COMPENSATION COMMITTEE OF THE BOARD
                              OF DIRECTORS

Compensation Committee Interlocks and Insider Participation.  The
members  of  the  Compensation  Committee  are  Paul  C.  Ahrens,
Edward  M. Giles and Page E. Golsan III.  Mr. Ahrens is  formerly
an officer of the Company.

Summary of Cash and Certain Other Compensation
- ----------------------------------------------
The   following   table  provides  certain  summary   information
concerning compensation paid by the Company to those persons  who
were  at  March 31, 1998, the Company's Chief Executive  Officer,
Chief  Financial Officer and one other executive officer  of  the
Company whose salary and bonus exceeded $100,000 during the  last
fiscal  year  (the  "Named Persons") for the fiscal  years  ended
March 31, 1998, 1997 and 1996:

<TABLE>
<CAPTION>
<S>              <C>       <C>         <C>       <C>            <C>

                                 Summary Compensation Table
                                 --------------------------- 
                                                  Long-Term       All Other
                         Annual Compensation      Compensation  Compensation($)(2)
                     ---------------------------  ------------- ------------------ 
Name and                                             Stock          
Principal Position Year(1)   Salary ($) Bonus ($)  Options (#)
- ------------------ -------  ----------- ---------- ----------- -------------------                                             
M. ("Sreeni")       1998      150,000          -   25,000           12,500
Sreenivasan         1997      150,000     95,000   50,000            7,125
President & Chief   1996      132,000     60,000   66,000            3,203
Executive Officer                             

Philip L. Knutson   1998      108,000          -   20,000           12,200
Vice President of   1997      108,000     63,000   40,000            9,500
Research and        1996       95,000     43,000   50,000            3,531
Development*                      

Charles B. Williams 1998       88,000          -   20,000            7,950
Vice President of   1997       88,000     57,000   32,000            6,544
Finance and         1996       75,000     35,000   34,000            3,122
Administration &                  
Chief Financial
Officer
</TABLE>
_______________________
*Dr.  Knutson resigned his position with the Company  on  May  8,
 1998.
(1)Fiscal year ended March 31.
(2)Represents Company contributions to the account of  the  Named
 Persons under the Company's 401(k) plan.

<PAGE> 39

Stock Option Grants in Last Fiscal Year
- ---------------------------------------
The  following  table provides information, with respect  to  the
Named  Persons,  concerning the grant  of  stock  options  during
fiscal year 1998.

<TABLE>
<CAPTION>
<S>             <C>          <C>      <C>     <C>         <C>       <C>
                                     
              Stock Options Grants in the Last Fiscal Year(1)
              -----------------------------------------------
                                                          Potential Realizable
                                                            Value at Assumed
                                                             Annual Rates of
                                                               Stock Price
                                                               Appreciation
                            Individual Grants              (Through Expiration Date)
                  ---------------------------------------- --------------------------
                    Options                                   
                    Granted     % of   Exercise                     
                    (# of       Total   Price   Expiration  5% per    10% per
Name                Shares)    Options  ($/Sh)     Date     year(4)   year(4)
                                 (2)     (3)
- -------------      ---------- -------- ------- ----------- --------- ----------
M. ("Sreeni")    
Sreenivasan          25,000     12.3%   $7.13   July 2007   $112,000   $284,000                  

Philip L. Knutson*   20,000      9.9%   $7.13   July 2007    $89,600   $227,200
                                                
Charles B.     
Williams             20,000      9.9%   $7.13   July 2007    $89,600   $227,200
</TABLE>
_______________________

*Dr.  Knutson resigned his position with the Company  on  May  8,
 1998.
(1)    The  Company has not granted any stock appreciation rights
 (SARs).
(2)    Based on an aggregate of 203,000 options being granted  to
 all employees during the fiscal year ended March 31, 1998.
(3)    These  options  were  granted  under  the  Company's  1995
 Incentive  Compensation Plan in July 1997, and have an  exercise
 price  equal  to  the fair market value of the Company's  Common
 Stock  as  of the date of the grant. These grants vest  annually
 over a two-year period ending April 1999.
(4)    The  5% and 10% assumed rates of appreciation are mandated
 by  the  rules of the Securities and Exchange Commission and  do
 not  represent  the Company's estimate or projection  of  future
 prices for its Common Stock.

Stock  Option  Exercises in Last Fiscal Year and Fiscal Year-End
- ----------------------------------------------------------------
                  Stock Option Values
                  -------------------
The  following  table provides information, with respect  to  the
Named Persons, concerning the options granted to them during  the
last fiscal year and the options held by them at March 31, 1998.

<TABLE>
<CAPTION>
<S>            <C>       <C>         <C>     <C>         <C>      <C>          
                                     
  Option Exercises in Last Fiscal Year and Fiscal Year End Stock Option Values
  ----------------------------------------------------------------------------
                   Shares     Value                          Value of
                Acquired on  Realized    Number of        Unexercised In-the-
Name              Exercise     ($)      Unexercised        Money Options at
                     (#)                 Options at        Fiscal Year End
                                      Fiscal Year End          ($)(1)
- -------------    ---------  --------  ----------------    -------------------
                                      Exer-     Unexer-   Exer-     Unexer-
                                      cisable   cisable   cisable   cisable   
- -------------    ---------  --------  -------   --------  --------- ---------
M. ("Sreeni")  
Sreenivasan       125,000   $415,250   91,000    50,000    $221,100     $0   

Philip L.          56,240   $233,958  110,000    40,000    $326,300     $0
Knutson*           

Charles B.        
Williams           93,720   $256,822   16,000    36,000          $0     $0      
</TABLE>
_______________________
*Dr.  Knutson resigned his position with the Company  on  May  8,
 1998.
(1)    Represents  the difference between the exercise  price  of
 the  options  with  exercise prices below $6.19  and  the  $6.19
 closing price of the Company's Common Stock on March 31, 1998.

<PAGE> 40

Comparison of Total Cumulative Shareholder Equity
- -------------------------------------------------
The following graph sets forth the Company's total cumulative
shareholder return as compared to the Nasdaq Stock Market (U.S.)
and S&P Specialty Chemicals Indexes for the period March 31, 1993
through March 31, 1998.  The total shareholder return assumes
$100 invested at the beginning of the period in Common Stock of
the Company, Nasdaq Stock Market Index  (U.S.) and the S&P
Specialty Chemicals Index.  Historic stock price performance is
not necessarily indicative of future stock price performance.


Edgar Representation of Data Points Used in Printed Graphic
<TABLE>
<CAPTION>
<S>       <C>       <C>            <C>            <C>

                                                             
                                        Nasdaq Stock        S&P
                       Synthetech       Market Index     Specialty
                                           (U.S.)        Chemicals
                                                           Index
                       -----------      ------------     --------- 
           1993            100              100             100
           1994            137              108             106
           1995            122              120             107
           1996            356              163             138
           1997            452              181             124
           1998            367              275             157
</TABLE>
All data points are at March 31.

Employment Agreements

In July, 1997, the Company entered into Employment Agreements
with Messrs. Sreenivasan, Williams and Knutson (collectively,
"Executives" and individually, "Executive").  In addition to
providing for an annual base salary, the Agreements have certain
noncompetition and nonsolicitation provisions.  Pursuant to the
Agreements, the Company will pay the Executives certain payments
after termination of employment for any reason other than death.
Specifically, the Company will pay an amount equal to the base
salary earned by the Executive during the twelve month period
immediately preceding the date of termination plus an additional
amount for one year of health insurance coverage.  The Company
has certain rights to extend the agreements and payments under
the Agreement for a total of 24 months after termination of an
Executive's employment.  In the event the Executive should die
during the payment period, the Company's payment obligation
immediately terminates.

Compensation of Directors
- -------------------------
In  fiscal  1997, the Company established a policy to  grant  all
current  directors who are not employees (other than Mr.  Ahrens,
who  is a founder of the Company) a nonqualified stock option for
15,000 shares vesting at the rate of 3,000 shares at the next and
each  of  the subsequent four annual shareholder meetings.   This
option is intended to provide the outside director with the

<PAGE> 41

equivalent  of  an annual grant of 3,000 shares and  the  Company
does not anticipate granting any additional options until the end
of  the fifth year.  The exercise price of these options will  be
set  at the fair market value of the Common Stock on the date  of
the grant.



Since  fiscal 1998, the Company has provided directors  who  are
not  employees  of  the Company an annual fee  of  $4,000.   The
Company also established a policy to grant all new directors who
are  not  employees  a one-time nonqualified  stock  option  for
10,000 shares which vests immediately.  Thus, new directors  who
are  not employees of the Company will receive this 10,000 share
option  in addition to the ongoing 15,000 share option described
above.  Like the 15,000 share option, the exercise price of  the
options will be set at the fair market value of the Common Stock
on the date of grant.

                                
       ITEM 12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL
                      OWNERS AND MANAGEMENT


The  following  table sets forth the number of shares  of  Common
Stock and percentage of outstanding shares of Common Stock of the
Company owned as of April 1, 1998, by persons who hold of  record
or  are  known to beneficially own 5% or more of the  outstanding
common  stock  of the Company, each nominee and director  of  the
Company,  the Named Persons and all officers and directors  as  a
group.

<TABLE>
<CAPTION>
<S><C>                           <C>                     <C>
Name and Address of            Amount and Nature       Percent
Beneficial Owner                 of Beneficial        of Class
                                   Ownership
- -------------------          -------------------    -----------
Paul C. Ahrens                    1,465,491(1)           10.4%
1290 Industrial Way
Albany, OR

M. ("Sreeni") Sreenivasan          603,810(2)             4.2%(3)
1290 Industrial Way
Albany, OR

Howard L. Farkas                    89,042(4)              *
5460 South Quebec Street
Suite 300
Englewood, CO

Edward M. Giles                    271,000(5)             1.9%(3)
645 Madison Avenue
8th Floor
New York, NY  10022

Page E. Golsan, III                41,000(6)              *
3205 Canterbury Drive,
South
Salem, OR

<PAGE> 42

Name and Address of           Amount and Nature      Percent
Beneficial Owner                of Beneficial       of Class
                                  Ownership          
- ---------------------      --------------------   -------------
Donald M. Kuhla, Ph.D.            13,000(7)                *
1787 Sentry Parkway West
Bldg. 18, Suite 301
Blue Bell, PA  19422

Philip L. Knutson, Ph.D.+        400,840(8)               2.8%(3)
1290 Industrial Way
Albany, OR

Charles B. Williams              234,120(9)               1.7%(3)
1290 Industrial Way
Albany, OR

Brown Capital Management         752,400(10)              5.3%
809 Cathedral Street
Baltimore, MD  21201

All Officers and Directors      3,171,303(1)(2)(4)(5)    21.8%(3)
as a Group (9 persons)                   (6)(7)(8)(9)
</TABLE>
______________________
*less than 1%.
+Dr.  Knutson resigned his position with the Company  on  May  8,
 1998.
(1)    Includes 14,000 shares of common stock which are owned  of
 record  by  a  private foundation of which  Mr.  Ahrens  is  the
 President.  Mr. Ahrens disclaims beneficial ownership  of  these
 shares.
(2)     Includes  128,500  shares  of  common  stock  which   Mr.
 Sreenivasan  has  the  right to acquire  immediately  or  within
 sixty  (60)  days pursuant to employee stock options.   Excludes
 12,500  shares  of  common  stock  issuable  pursuant  to  stock
 options  held  by Mr. Sreenivasan which are not exercisable  now
 or within sixty (60) days.
(3)    The  denominator  used in calculating  the  percentage  is
 equal  to  the number of shares outstanding plus the  number  of
 shares the beneficial owner (or group of beneficial owners)  has
 a  right to acquire immediately or within sixty days pursuant to
 warrants or options.
(4)    Includes  39,042 shares of common stock which  Mr.  Farkas
 has  the right to acquire immediately or within sixty (60)  days
 pursuant to stock options.  Mr. Farkas disclaims ownership  over
 50,000  shares of common stock held in his name which have  been
 pledged as security for a loan and over which Mr. Farkas has  no
 voting   control.   Excludes  25,958  shares  of  common   stock
 issuable pursuant to stock options held by Mr. Farkas which  are
 not exercisable now or within sixty (60) days.
(5)    Includes 10,000 shares of common stock which Mr. Giles has
 the right to acquire immediately or
 within  sixty  (60)  days pursuant to stock  options.   Excludes
 15,000  shares  of  common  stock  issuable  pursuant  to  stock
 options  held  by  Mr. Giles which are not  exercisable  now  or
 within  sixty (60) days.  Also includes 60,000 shares of  common
 stock held by two individuals who have granted to Mr. Giles  the
 investment  powers  associated with  these  shares.   Mr.  Giles
 disclaims beneficial ownership over these 60,000 shares.
(6)    Includes 3,000 shares of common stock which Mr. Golsan has
 the  right  to  acquire immediately or within  sixty  (60)  days
 pursuant  to  stock options.  Excludes 12,000 shares  of  common
 stock  issuable  pursuant to stock options held  by  Mr.  Golsan
 which are not exercisable now or within sixty (60) days.
(7)    Includes 10,000 shares of common stock which Dr. Kuhla has
 the  right  to  acquire immediately or within  sixty  (60)  days
 pursuant  to  stock options.  Excludes 15,000 shares  of  common
 stock  issuable  pursuant to stock options  held  by  Dr.  Kuhla
 which are not exercisable now or within sixty (60) days.
(8)    Includes 140,000 shares of common stock which Dr.  Knutson
 has  the right to acquire immediately or within sixty (60)  days
 pursuant  to employee stock options.  Excludes 10,000 shares  of
 common  stock  issuable pursuant to stock options  held  by  Dr.
 Knutson  which  are  not exercisable now or  within  sixty  (60)
 days.

<PAGE> 43

(9)    Includes 42,000 shares of common stock which Mr.  Williams
 has  the right to acquire immediately or within sixty (60)  days
 pursuant  to employee stock options.  Excludes 10,000 shares  of
 common  stock  issuable pursuant to stock options  held  by  Mr.
 Williams  which  are not exercisable now or  within  sixty  (60)
 days.
(10)   Based  on Schedule 13(g) filings, pursuant to which  Brown
 Capital  Management  disclosed  controlling  752,400  shares  of
 common  stock  with sole dispositive power.   Of  these  shares,
 Brown  Capital  Management further disclosed that  it  had  sole
 voting power over 695,800 shares of common stock.

                                
           ITEM 13.  CERTAIN RELATIONSHIPS AND RELATED
                          TRANSACTIONS

Not applicable.
                                
                             PART IV
                                
      ITEM 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND
                       REPORTS ON FORM 8-K

(a)(1)  and  (2)  FINANCIAL STATEMENTS  AND  FINANCIAL  STATEMENT
SCHEDULES.

The information required by this item is included under Item 8 of
this Report.

(a)(3)    EXHIBITS.

The  following documents are filed as part of this Annual  Report
on Form 10-K:

3(i),(1)     Articles of Incorporation of Synthetech, Inc., as amended.

3(ii),(9)    Bylaws of Synthetech, Inc., as amended.

10.1(2)(3)   License   Agreement   dated  March   16,   1990   between
             Synthetech, Inc. and Miwon Co. Ltd.

10.2(2)(4)   Supply   Agreement   dated  January   3,   1989   between
             Synthetech, Inc. and Biomeasure, Incorporated.

10.3(2)(4)   License   Agreement  dated  January   3,   1989   between
             Synthetech, Inc. and Biomeasure, Incorporated.

10.4(2)+     Synthetech,  Inc. Amended and Restated 1984 Stock  Option
             and Bonus Plan.

10.5(5)+     Synthetech, Inc. 1990 Stock Option Plan.

10.6(8)      Amendment  No. 1 to Stock and Warrant Purchase  Agreement
             between the Company and JB dated as of March 26, 1996.

10.7(6)      Agreement   dated  September  30,  1991   Among   Certain
             Shareholders of the Company.

<PAGE> 44

10.8(7)     Agreement and Release dated as of March 31, 1995  between
            Synthetech,   Inc.  and  Paul  C.  Ahrens  (the   "Ahrens
            Agreement").

10.9(8)     Addendum to Ahrens Agreement dated as of April 1, 1996.

10.10(9)    1995 Incentive Compensation Plan, as amended.

10.11(9)    Promissory  Note dated September 8, 1995 from Synthetech,
            Inc. to United States National Bank of Oregon.

10.12(9)    Change  in  Terms  Agreement  dated  September  12,  1996
            between Synthetech, Inc. and United States National  Bank
            of Oregon.

10.13       Letter   Agreement   dated  August   28,   1997   between
            Synthetech,  Inc.  and  United States  National  Bank  of
            Oregon.

10.14(9)    Nonqualified Stock Option dated as of November 7, 1996 to
            purchase  50,000 shares of Common Stock issued to  Howard
            L. Farkas.

10.15(9)    Nonqualified Stock Option dated as of November 7, 1996 to
            purchase  15,000 shares of Common Stock issued to  Howard
            L. Farkas.

10.16(9)    Nonqualified Stock Option dated as of November 7, 1996 to
            purchase 15,000 shares of Common Stock issued to Page  E.
            Golsan III.

10.17(9)    Synthetech,  Inc. Purchase Order dated June 17,  1996  to
            R.L. Reimers Construction in the amount of $250,000.

10.18(9)    Synthetech, Inc. Purchase Order dated August 23, 1996  to
            CE/Western in the amount of $240,000.

10.19(9)    Synthetech, Inc. Purchase Order dated September  4,  1996
            to R.L. Reimers Construction in the amount of $189,000.

10.20(9)    Synthetech, Inc. Purchase Order dated November 7, 1996 to
            R.L. Reimers Construction in the amount of $1,870,700.

10.21(9)    Synthetech, Inc. Purchase Order dated February  20,  1997
            to Olsson Industrial Electric in the amount of $335,864.

10.22(9)    Synthetech,  Inc. Purchase Order dated  May  2,  1997  to
            Oregon  Industrial Contractors, Inc.  in  the  amount  of
            $626,276.

<PAGE> 45

10.23(9)+   Form  of  contract entered into by each of Mr. Philip  L.
            Knutson,  Mr. M. Sreenivasan and Mr. Charles B.  Williams
            dated July 18, 1997.

23          Consent of Arthur Andersen LLP.

27          Financial Data Schedule for Twelve Months Ended March 31,
            1998.

__________________________

+ Management contract or compensatory plan.

(1)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1991.

(2)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1990.

(3) Confidential treatment of certain portions of this document was
granted by the Commission on May 7, 1990 (File No. 33-27566).

(4) Confidential treatment of certain portions of this document was
granted  by  the  Commission on January 10, 1990  (File  No.  33-
27566).

(5)  Incorporated by reference to Exhibit A to the definitive  copy
of  registrant's Proxy Statement (dated October 23, 1990) for the
1990 Annual Meeting of Shareholders.

(6)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1992.

(7)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1995.

(8)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1996.

(9)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1997.

(10)  Incorporated   by   reference  to  the  exhibits   filed   with
registrant's  Quarterly  Report on Form 10_Q  for  the  quarterly
period ended June 30, 1997.

(b)  Reports on Form 8-K
     
     None.

<PAGE> 46

(c)  See (a) (3) above.

(d)  See (a) (1) and (2) above.

<PAGE> 47
                           SIGNATURES

Pursuant  to  the  requirements of Section 13  or  15(d)  of  the
Securities  Exchange Act of 1934, the Registrant has duly  caused
this  Report  to  be  signed on its behalf  by  the  undersigned,
thereunto duly authorized.
                               
Date:  June 26, 1998           SYNTHETECH, INC.
                               (Registrant)
                               
                               By /s/  M. Sreenivasan
                                  M. ("Sreeni") Sreenivasan
                                  President and Chief Executive
                                  Officer

Pursuant  to the requirements of the Securities Exchange  Act  of
1934,  this Report has been signed below by the following persons
on  behalf  of the Registrant and in the capacities  and  on  the
dates indicated.

       Signature                       Title                    Date
                                                                  
/s/  M. Sreenivasan       President, Chief Executive          June 26,
     M. ("Sreeni")        Officer (Principal Executive          1998
      Sreenivasan         Officer) and Director
                                                                  
/s/  Charles B. Williams  Vice President of Finance and       June 26,
  Charles B. Williams     Administration, Chief Financial       1998
                          Officer, Secretary and Treasurer
                          (Principal Financial Officer and
                          Principal Accounting Officer),
                          and Director
                                                                  
/s/  Paul C. Ahrens       Chairman of the Board               June 26,
     Paul C. Ahrens                                             1998
                                                                  
/s/  Howard L. Farkas     Director                            June 26,
    Howard L. Farkas                                            1998
                                                                  
/s/  Edward M. Giles      Director                            June 26,
    Edward M. Giles                                             1998
                                                                  
/s/  Page E. Golsan, III  Director                            June 26,
  Page E. Golsan, III                                           1998
                                                                  
/s/   Donald M. Kuhla,    Director                            June 26,
         Ph.D.                                                  1998
 Donald M. Kuhla, Ph.D.

<PAGE> 48

                        INDEX TO EXHIBITS
                                              Sequential Page No.

3(i),(1)     Articles  of  Incorporation of Synthetech,
             Inc., as amended.

3(ii),(9)    Bylaws of Synthetech, Inc., as amended.

10.1(2)(3)   License  Agreement dated  March  16,  1990
             between  Synthetech, Inc.  and  Miwon  Co.
             Ltd.

10.2(2)(4)   Supply  Agreement dated  January  3,  1989
             between  Synthetech, Inc. and  Biomeasure,
             Incorporated.

10.3(2)(4)   License  Agreement dated January  3,  1989
             between  Synthetech, Inc. and  Biomeasure,
             Incorporated.

10.4(2)+     Synthetech, Inc. Amended and Restated 1984
             Stock Option and Bonus Plan.

10.5(5)+     Synthetech, Inc. 1990 Stock Option Plan.

10.6(8)      Amendment  No.  1  to  Stock  and  Warrant
             Purchase Agreement between the Company and
             JB dated as of March 26, 1996.

10.7(6)      Agreement  dated September 30, 1991  Among
             Certain Shareholders of the Company.

10.8(7)      Agreement   and  Release   dated   as   of
             March  31,  1995 between Synthetech,  Inc.
             and    Paul   C.   Ahrens   (the   "Ahrens
             Agreement").

10.9(8)      Addendum to Ahrens Agreement dated  as  of
             April 1, 1996.

10.10(9)     1995   Incentive  Compensation  Plan,   as
             amended.

10.11(9)     Promissory  Note dated September  8,  1995
             from  Synthetech,  Inc. to  United  States
             National Bank of Oregon.

10.12(9)     Change  in Terms Agreement dated September
             12,  1996  between  Synthetech,  Inc.  and
             United States National Bank of Oregon.

10.13        Letter  Agreement dated  August  28,  1997
             between Synthetech, Inc. and United States
             National Bank of Oregon.

10.14(9)     Nonqualified  Stock  Option  dated  as  of
             November 7, 1996 to purchase 50,004 shares
             of Common Stock issued to Howard L. Farkas.

<PAGE> 49

10.15(9)     Nonqualified  Stock  Option  dated  as  of
             November 7, 1996 to purchase 15,000 shares
             of Common Stock issued to Howard L. Farkas.

10.16(9)     Nonqualified  Stock  Option  dated  as  of
             November 7, 1996 to purchase 15,000 shares
             of  Common Stock issued to Page E.  Golsan,
             III.

10.17(9)     Synthetech, Inc. Purchase Order dated June
             17,  1996 to R.L. Reimers Construction  in
             the amount of $250,000.

10.18(9)     Synthetech,  Inc.  Purchase  Order   dated
             August  23,  1996  to  CE/Western  in  the
             amount of $240,000.

10.19(9)     Synthetech,  Inc.  Purchase  Order   dated
             September   4,   1996  to   R.L.   Reimers
             Construction in the amount of $189,000.

10.20(9)     Synthetech,  Inc.  Purchase  Order   dated
             November   7,   1996   to   R.L.   Reimers
             Construction in the amount of $1,870,700.

10.21(9)     Synthetech,  Inc.  Purchase  Order   dated
             February  20,  1997  to Olsson  Industrial
             Electric in the amount of $335,864.

10.22(9)     Synthetech, Inc. Purchase Order dated  May
             2,  1997 to Oregon Industrial Contractors,
             Inc. in the amount of $626,276.

10.23(10)+   Form of contract entered into by each
             of   Mr.   Philip  L.  Knutson,   Mr.   M.
             Sreenivasan  and Mr. Charles  B.  Williams
             dated July 18, 1997.

23           Consent of Arthur Andersen LLP.

27           Financial Data Schedule for Twelve Months Ended March 31,
             1998.

__________________________

+ Management contract or compensatory plan.

(1)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1991.

(2)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1990.

(3)   Confidential treatment of certain portions of this document was
granted by the Commission on May 7, 1990 (File No. 33-27566).

(4)   Confidential treatment of certain portions of this document was
granted  by  the  Commission on January 10, 1990  (File  No.  33-
27566).

<PAGE> 50

(5)   Incorporated by reference to Exhibit A to the definitive  copy
of  registrant's Proxy Statement (dated October 23, 1990) for the
1990 Annual Meeting of Shareholders.

(6)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1992.

(7)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1995.

(8)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1996.

(9)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1997.

(10)  Incorporated   by   reference  to  the  exhibits   filed   with
registrant's  Quarterly  Report on Form 10-Q  for  the  quarterly
period ended June 30, 1997.

<PAGE> 51


                                                    Exhibit 10.13
                                                     to Form 10-K




                       ACKNOWLEDGMENT COPY
                                
August 28, 1997

Mr. Charles B. Williams, 
Vice President Finance and Administration
Synthetech, Inc.
1290 Industrial Way
PO Box 646
Albany OR 97321


Dear Mr. Williams:

U.  S.  Bank  has approved a revolving line of credit  under  the
terms and conditions outlined below:

Borrower:            Synthetech, Inc.

Guarantor:           None

Maximum Loan Amount: $1,000,000

Purpose:             General corporate purposes.

Interest Rate:       Fully  floating variable interest rate equal
                     to  U.S.  Bank's  prime rate.   U.S.  Bank's
                     prime  rate  is  the rate of interest  which
                     U.S.  Bank from time to time establishes  as
                     its  prime rate and is not, for example, the
                     lowest  rate  of  interest which  U.S.  Bank
                     collects  from  any  borrower  or  class  of
                     borrowers.   All interest shall be  computed
                     on  the  basis  of a 360-day  year  and  the
                     actual number of days elapsed.

Loan  Fee:           Non-refundable upfront annual loan  fee  of $1,250.

Loan Advances:       Advances  may be requested by Borrower  from
                     time  to  time in accordance with the  terms
                     of the promissory note.

<PAGE> 52

                     All  advances  shall be  made  at  the  sole
                     option  of U.S. Bank.  U.S. Bank may decline
                     to  make any advances and may terminate  the
                     availability of advances at any time.

Maturity Date:       Payable on demand.

Repayment:           Principal  and interest payable  on  demand.
                     Interest  payable  monthly  in  absence   of
                     demand.

Collateral:          Unsecured.

Insurance:           Borrower  shall maintain insurance  in  such
                     amounts  and  covering such  risks  as  U.S.
                     Bank shall require.

Financial Reporting: Annual   CPA  audited  financial   statement
                     within  90 days after the end of each fiscal
                     year.

                     At   any   time  requested  by  U.S.   Bank,
                     Borrower   shall   furnish  any   additional
                     information  regarding Borrower's  financial
                     condition and business operations that  U.S.
                     Bank   requests.    This   information   may
                     include,  but  is not limited to,  financial
                     statements,  tax  returns, lists  of  assets
                     and  liabilities, agings of receivables  and
                     payables,  inventory schedules, budgets  and
                     forecasts.

Loan Documentation:  Borrower  shall  deliver to U.S.  Bank  duly
                     executed  promissory note, deeds  of  trust,
                     mortgages,  security  agreements,  financing
                     statements,   loan  agreements,  guaranties,
                     borrower  authorizations,  attorney  opinion
                     letters    and   other   documents    ("Loan
                     Documents")  as  required by  U.S.  Bank  in
                     form  and  substance  satisfactory  to  U.S.
                     Bank and its counsel.

                     Non-Assignable:           This        credit
                     accommodation   may  not  be   assigned   by
                     Borrower.   No guarantor or any third  party
                     is  intended as a third-party beneficiary or
                     has any right to rely hereon.

Arbitration:         Borrower  and U.S. Bank hereby agree  to  be
                     bound   by  the  terms  of  the  Arbitration
                     clause attached hereto as Exhibit A.

Expenses:            Borrower shall reimburse U.S. Bank  for  all
                     out-of-pocket    expenses    incurred     in
                     connection  with  this credit  accommodation
                     upon    demand,   whether   or   not    this
                     transaction  closes  or  is  funded.    Such
                     expenses  shall include, without limitation,
                     attorney fees, title insurance fees,  travel
                     costs,   examination  expenses,  and  filing
                     fees.

<PAGE> 53


This  letter  summarizes certain principal terms  and  conditions
relating  to  the loan and supersedes all prior oral and  written
negotiations, understandings, representations and agreements with
respect  to  the loan.  However, the Loan Documents will  include
additional   terms,   conditions,   covenants,   representations,
warranties  and  other  provisions which  U.S.  Bank  customarily
includes in similar transactions or which U.S. Bank determines to
be  appropriate  to  this  transaction.   Except  to  the  extent
modified by any other agreement, all terms, conditions, covenants
and  other provisions of this letter shall remain in effect until
the revolving line of  credit (including any renewals, extensions
or  modifications) is terminated and the loan balance is paid  in
full,  and by signing below, Borrower agrees to comply  with  all
such provisions.

In  addition  to the events of default in any Loan Document,  any
failure to comply with any term, condition or obligation in  this
letter  shall constitute an event of default under  each  of  the
Loan Documents.  The provisions of this letter shall survive  the
closing  of the loan and the execution and delivery of  the  Loan
Documents.   In the event of a conflict between this  letter  and
the  Loan  Documents,  the  terms of  the  Loan  Documents  shall
control.

Under Oregon law, most agreements, promises and commitments  made
by  lenders  after  October 3, 1989 concerning  loans  and  other
credit extensions which are not for personal, family or household
purposes or secured solely by the borrower's residence must be in
writing, express consideration and be signed by the lender to  be
enforceable.

If  the  above terms and conditions are acceptable to you, please
sign,  date  and return the acknowledgment copy of  this  letter,
together  with  the  non-refundable loan fee  in  the  amount  of
$1,250.

Sincerely,



Robert V. Albright
Assistant Vice President
(503) 399-4139

Borrower  hereby accepts U. S. Bank's offer to extend  credit  on
the   terms  and  conditions  stated  above  and  agrees  to  the
Arbitration clause set forth in Exhibit A attached hereto.

                    Synthetech, Inc.

By:    _______________________________

Title: _______________________________

Date: _______________________________

<PAGE> 54

EXHIBIT A

ARBITRATION:   U.S.  Bank and Borrower agree that  all  disputes,
claims and controversies between them, whether individual, joint,
or  class  in  nature, arising from this letter or the  revolving
line   of  credit  or  otherwise,  including  without  limitation
contract and tort disputes, shall be arbitrated pursuant  to  the
Rules  of  the American Arbitration Association, upon request  of
either  party.   No  act  to take or dispose  of  any  collateral
securing  any loan shall constitute a waiver of this  arbitration
agreement.    This   includes,  without   limitation,   obtaining
injunctive  relief or a temporary restraining order;  foreclosing
by notice and sale under any deed of trust or mortgage; obtaining
a  writ  of attachment or imposition of a receiver; or exercising
any  rights  relating to personal property, including  taking  or
disposing  of  such  property with or  without  judicial  process
pursuant  to  Article  9  of the Uniform  Commercial  Code.   Any
disputes,  claims, or controversies concerning the lawfulness  or
reasonableness  or any act, or exercise of any right,  concerning
any collateral securing any loan, including any claim to rescind,
reform,  or  otherwise  modify any  agreement,  relating  to  the
collateral securing any loan, shall also be arbitrated,  provided
however that no arbitrator shall have the right or other power to
enjoin or restrain any act of any party.  Judgment upon any award
rendered  by  any arbitrator may be entered in any  court  having
jurisdiction.   Nothing  herein shall  preclude  any  party  from
seeking  equitable relief from a court of competent jurisdiction.
The statute of limitations, estoppel, waiver, laches, and similar
doctrines  which  would  otherwise be  applicable  in  an  action
brought  by  a  party  shall  be applicable  in  any  arbitration
proceeding,  and  the  commencement of an arbitration  proceeding
shall  be  deemed  the  commencement  of  any  action  for  these
purposes.   The  Federal  Arbitration  Act  shall  apply  to  the
construction, interpretation, and enforcement of this arbitration
provision.

<PAGE> 55



                                                       Exhibit 23
                                                     to Form 10-K
                                
                                
                                
            CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS
                                
                                
As independent public accountants, we hereby consent to the
incorporation of our report dated May 14, 1998 included in this
Form 10-K for the year ended March 31, 1998, into Synthetech,
Inc.'s previously filed Registration Statement Nos. 33-45913, 33-
64621 and 333-8203.


Arthur Andersen LLP
Portland, Oregon,
June 26, 1998
                                                                 


<TABLE> <S> <C>


<PAGE>

<ARTICLE> 5
<LEGEND>
This schedule contains summary financial information extracted
from the March 31, 1998 10-K Balance Sheets, Income Statements,
and Cash Flow Statements, and is qualified in its entirety by
reference to such financial statements.
</LEGEND>
       
<S>                                   <C>
<PERIOD-TYPE>                         12-Mos
<FISCAL-YEAR-END>                     Mar-31-1998
<PERIOD-END>                          Mar-31-1998
<CASH>                                  4976000
<SECURITIES>                                  0
<RECEIVABLES>                           1470000
<ALLOWANCES>                              15000
<INVENTORY>                             3184000
<CURRENT-ASSETS>                        9920000
<PP&E>                                  9439000
<DEPRECIATION>                                0
<TOTAL-ASSETS>                         19364000
<CURRENT-LIABILITIES>                   1683000
<BONDS>                                       0
<COMMON>                                  14000
                         0
                                  0
<OTHER-SE>                             17306000
<TOTAL-LIABILITY-AND-EQUITY>          193640000
<SALES>                                 8321000
<TOTAL-REVENUES>                        8321000
<CGS>                                   5320000
<TOTAL-COSTS>                           6710000
<OTHER-EXPENSES>                              0
<LOSS-PROVISION>                              0
<INTEREST-EXPENSE>                            0
<INCOME-PRETAX>                         1923000
<INCOME-TAX>                             702000
<INCOME-CONTINUING>                     1221000
<DISCONTINUED>                                0
<EXTRAORDINARY>                               0
<CHANGES>                                     0
<NET-INCOME>                            1221000
<EPS-PRIMARY>                               .09
<EPS-DILUTED>                               .09
        

</TABLE>


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