SYNTHETECH INC
10-K, 1999-06-10
INDUSTRIAL ORGANIC CHEMICALS
Previous: AMBI INC, 424B3, 1999-06-10
Next: SEITEL INC, 10-Q/A, 1999-06-10



<PAGE>

        UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                     Washington, D.C. 20549

                            FORM 10-K


                           (Mark One)
[X]  ANNUAL REPORT PURSUANT TO SECTION 13 or 15(d) OF THE
     SECURITIES EXCHANGE ACT OF 1934
     For the fiscal year ended March 31, 1999

[  ] TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE
     SECURITIES EXCHANGE ACT OF 1934
     For the transition period from __________ to __________
Commission file number 0-12992

                        SYNTHETECH, INC.
     (Exact name of registrant as specified in its charter)

             Oregon                               84-0845771
     (State or other jurisdiction               (I.R.S. Employer
     of incorporation or organization)           Identification No.)

     1290 Industrial Way, Albany, Oregon             97321
     (Address  of  principal  executive            (Zip Code)
      offices)

     Registrant's telephone number, including area code: 541/967/6575

     Securities registered pursuant to
     Section 12(b) of the Act:                          None

     Securities registered pursuant to
     Section 12(g) of the Exchange Act:

                         Common Stock, $.001 Par Value
                               (Title of class)
Indicate  by check mark whether registrant (1) filed all  reports
required  to  be  filed by Section 13 or 15(d) of the  Securities
Exchange  Act  of  1934 during the past 12 months  (or  for  such
shorter  period  that the registrant was required  to  file  such
reports),  and  (2) has been subject to such filing  requirements
for the past 90 days.   YES  X   NO

Indicate  by  check  mark if disclosure of delinquent  filers  in
response  to  Item 405 of Regulation S-K is not contained  herein
and will not be contained, to the best of registrant's knowledge,
in  definitive  proxy or information statements  incorporated  by
reference in Part III of this Form 10-K or any amendment to  this
Form 10-K.  [   ]

As  of  May  24, 1999, the aggregate market value of  the  voting
stock  held  by nonaffiliates of the registrant was approximately
$49  million based upon $4.50 per share.  Shares of Common  Stock
held by each officer and director and by each person who owns  5%
or  more  of  the Common Stock have been excluded  in  that  such
persons   may  be  deemed  affiliates.   This  determination   of
affiliate  status  is not necessarily a conclusive  determination
for  other  purposes.  The number of the shares of the  Company's
Common   Stock  outstanding  on  May  24,  1999  was  14,251,630.

<PAGE> i


                        Table of Contents
                                                                        Page
PART I

Item 1 -  Business..................................................       1
Item 2 -  Properties................................................      10
Item 3 -  Legal Proceedings.........................................      10
Item 4 -  Submission of Matters To a Vote of Security Holders.......      11

PART II

Item 5 - Market for Registrant's Common Stock and Related Shareholder
         Matters....................................................      11
Item 6 - Selected Financial Data....................................      12
Item 7 - Management's Discussion and Analysis of Financial Condition
          and Results of Operations.................................      13
Item 7A- Quantitative and Qualitative Disclosure About Market Risk..      21
Item 8 - Financial Statements and Supplementary Data................      22
Item 9 - Changes In and Disagreements With Accountants on Accounting
          and Financial Disclosure..................................      39

PART III

Item 10- Directors and Executive Officers of the Registrant.........      39
Item 11- Executive Compensation.....................................      42
Item 12- Security Ownership of Certain Beneficial Owners and Management   48
Item 13- Certain Relationships and Related Transactions.............      49

PART IV

Item 14- Exhibits, Financial Statement Schedules and Reports on Form 8-K  50

Signatures                                                                52

<PAGE> 1

                             PART I

                        ITEM 1.  BUSINESS

This Annual Report contains forward-looking statements within the
meaning of Section 21E of the Securities Exchange Act of 1934, as
amended.   Actual  results  could differ  materially  from  those
projected  in the forward-looking statements and as a  result  of
the  factors set forth in "Factors Affecting Future Results"  and
elsewhere in this Report.

GENERAL

Synthetech,  Inc.,  an  Oregon  corporation  (the  "Company"   or
"Synthetech"),  produces chemically modified naturally  occurring
and synthetic amino acids which it refers to as "Peptide Building
Blocks"  ("PBBs").   These PBBs are pharmaceutical  intermediates
which  are purchased by major pharmaceutical companies,  emerging
biopharmaceutical companies and contract drug synthesis companies
as   starting   materials   in  the   manufacture   of   peptide,
peptidomimetic  small  molecule and other  drugs.  Using  organic
chemistry  and  biocatalysis  techniques,  the  Company  has  the
expertise and capacity to produce PBBs on a full cycle "grams  to
tons"  production basis for use in all stages of drug development
from   initial   discovery  through  approved,  marketed   drugs.
Synthetech's PBBs are currently used in a wide range of  peptide,
peptidomimetic  small molecule and other drugs under  development
and   on   the   market  for  the  treatment  of  AIDS,   cancer,
cardiovascular and other diseases.

MARKET OVERVIEW

The  market  for  PBBs is driven by the market for  the  peptide,
peptidomimetic small molecule and other drugs in which  they  are
incorporated.   Peptide drugs are chains of  generally  3  to  50
amino  acids and retain their peptide structure after  completion
of drug manufacturing.  Since naturally occurring peptides in the
human  body regulate several of its complex biochemical  systems,
researchers  have been investigating peptide drug  candidates  to
determine  their  ability  to regulate these  systems  to  either
promote   health   or   hinder  disease.  With   structures   and
characteristics similar to the body's own peptides  and  enzymes,
peptide  drugs generally  are quite potent.  Peptide  drugs  also
tend  to  be  administered through intravenous or other  non-oral
delivery  paths.   During clinical trials, PBB orders  for  these
candidates are typically multi-kilo in size.   At the  marketed
drug  stage,  orders  for PBBs for these drugs can reach the tens
of kilos to hundreds of kilos.

Researchers  have  also been investigating the combining  one  or
more  amino acids with other chemicals which are not amino  acids
to  create  drug candidates.  These drug candidates are  commonly
referred  to  as peptidomimetic small molecule drugs  since  they
exhibit peptide-like qualities in a smaller molecule which is not
a  defined sequence of amino acids. Peptidomimetic small molecule
drugs  typically  are less potent than peptide  drugs  since  the
human  body does not recognized them as peptides. They also often
are  able to be administered orally.  During clinical trials, PBB
orders  for these candidates can be in the hundreds of  kilos  to
low  tons size. At the marketed drug stage, orders for PBBs for
these drugs can reach the tons to tens of tons size.

<PAGE> 2

The  size  of the peptide and peptidomimetic small molecule  drug
market  is  a  function of the number of these  drugs  which  are
initially screened for therapeutic attributes, progress down  the
clinical  trial path toward regulatory approval and,  ultimately,
are  approved  and marketed. The market size for  any  individual
approved  drug  is  affected by many factors, including,  without
limitation,  size  of the patient population addressed,  efficacy
level,  level  and  frequency of side  effects,  method  of  drug
delivery,  cost and competing drugs. The size of the  PBB  market
for  peptide,  peptidomimetic small molecule and other  drugs  is
also a function of the quantities and varieties of PBBs necessary
to  produce  these drugs.  (See "Industry Factors" set  forth  in
Item   7,  Management's  Discussion  and  Analysis  of  Financial
Condition and Results of Operations).

STRATEGY

Synthetech's  strategy  is  to  emphasize  a  commitment  to  its
customers  from  the  early  phases  of  drug  discovery  through
clinical  development in order to develop larger  orders  as  the
drugs  receive  regulatory approval.   The  two  large-scale  PBB
orders in fiscal 1999 exemplified this strategy.  The Company had
supplied  PBBs for both of these drugs since their early clinical
development stages.

PRODUCT OVERVIEW

Peptide  Building Blocks.  PBBs are amino acids which  have  been
chemically  modified through organic chemistry  and  biocatalysis
techniques  to  enable  them to link with other  amino  acids  or
chemicals  in  a  particular defined  sequence.  These  PBBs  are
pharmaceutical  intermediates and are used as starting  materials
in  the manufacture of peptide, peptidomimetic small molecule and
other drugs.  The amino acids which are transformed into PBBs may
be  either natural amino acids (that is, amino acids which  occur
in  nature,  including their chiral or "mirror  image"  form)  or
synthetic  amino acids (that is, amino acids which  have  a  side
chain  that does not occur in nature).  Synthetech refers to  the
synthetic amino acids as "Specialty Amino Acids."

Since  1987,  the  Company has produced a wide range  of  natural
amino  acid  PBB  products.  The Company has also  developed  and
manufactures over three dozen Specialty Amino Acids.  The Company
uses  a  wide  array  of raw materials to  produce  PBBs.   These
materials   generally  are  in  adequate  supply  from   multiple
suppliers.

The  Company  has developed and scaled up process  technology  to
produce  this  wide range of PBB products in a  "grams  to  tons"
scale.  The Company continues to produce most bulk orders  on  an
as-ordered  basis.   The Company also maintains  small  inventory
quantities of many PBBs, permitting immediate deliveries.

At  March  31,  1999,  the dollar amount of  backlog  orders  was
$8.86  million, all of which the Company expects to  ship  during
fiscal  2000.   Over  two-thirds of the backlog  ($5.87  million)
represents  a  diverse  set of PBBs including  several  Specialty
Amino Acids for a handful of drugs advancing through the clinical
pipeline.  The remaining balance of this backlog ($2.99  million)
represents  the final shipments under a discontinued  large-scale
order.   (See  Item 7, "Management's Discussion and  Analysis  of
Financial  Condition and Results of Operations".)  At  March  31,
1998,  the  dollar amount of backlog orders was  $11.28  million.
This  backlog included $7.40 million attributable to  two  large-
scale orders.

<PAGE> 3

In  January  1990, the Company entered into supply and technology
agreements   with   Biomeasure  Incorporated,   a   Boston   area
biotechnology  company and a subsidiary of Groupe  Pharmaceutique
Beaufour-Ipsen of France with several Specialty Amino Acids under
development.  Under the supply agreement, the Company has  agreed
to  supply  all  of  Biomeasure's requirements for  a  particular
Specialty Amino Acid.  This agreement continues from year to year
unless  terminated in writing by one of the parties.  The Company
and  Biomeasure  are also parties to a license  agreement  giving
Biomeasure the option to receive a license to produce for its own
use the Specialty Amino Acids which are the subject of the supply
agreement  between  the  parties. Under this  license  agreement,
Biomeasure  must pay certain royalty amounts based on any  amount
it produces.

MARKETING

The   Company  markets  its  products  and  capabilities  through
attendance at trade shows, listings in biotechnology and chemical
industry   directories,   advertisements   in   chemical    trade
periodicals  and its Internet website.  In addition, the  Company
maintains  ongoing direct relationships with major pharmaceutical
firms,  emerging biopharmaceutical firms, contract drug synthesis
firms and other firms which it believes might have a need for its
products.   The Company typically sells its products directly  to
its  customers, although it uses sales representatives  for  some
European  sales and has often sold products to Japanese customers
through chemical trading firms.

CUSTOMERS

Although  the  Company  has  several  hundred  customers  in   25
countries, the Company expects that a few customers will continue
to  account  for  a  significant portion of revenues  each  year.
During  fiscal 1999, the top 20 customers represented 96% of  the
Company's  revenues.  Of these twenty customers, ten  were  major
pharmaceutical  companies,  four were emerging  biopharmaceutical
companies  and  six were contract drug synthesis companies.   The
Company  had  two  10% customers-F. Hoffman-La  Roche,  Ltd.  and
Pfizer,  Inc.-which individually accounted for over 44% and  20%,
respectively, of the Company's fiscal 1999 revenues.

For  the fiscal years ended March 31, 1999, 1998, and 1997, sales
to  international customers were $6.45 million, $2.85 million and
$4.14  million,  respectively, accounting for approximately  28%,
34%  and  32%,  respectively, of the  Company's  total  revenues.
These  sales were principally to Europe for fiscal 1999 and 1998,
and to Europe and Japan for fiscal 1997.  See Note J to Financial
Statements.

COMPETITION

Because  peptide  and  peptidomimetic small  molecule  drugs  are
relatively  new, the market in the past for PBBs has  been  quite
small -- with sales typically in the hundreds of kilos or smaller
size.   As  a  result,  the  PBB  market  has  not  attracted   a
significant  amount  of  direct  competition.   As   the   market
continues   to  grow  with  larger  order  sizes  becoming   more
prevalent, the Company has begun to see more competition.

Current  competition in multi-kilo quantities  of  natural  amino
acid  based  PBBs  comes  primarily from  several  European  fine
chemical companies.  Multi-ton order sizes of these natural  PBBs
have  begun  to  attract a wider group of approximately  a  dozen
domestic and international

<PAGE> 4

chemical  companies.  In the area of Specialty Amino  Acids,  the
Company has competition on a selected product basis at the multi-
kilo   scale  from  approximately  half  a  dozen  fine  chemical
producers  in  Europe, Japan and the United States.   Competition
also  increases for supplying PBBs for drug development  programs
that reach late clinical trials and move into approved status  as
a  result of the increased quantities typically required at these
stages  and  pharmaceutical company requirements to  have  second
sources of material available.  Many of the Company's competitors
have  technical, financial, selling and other resources available
to  them which are significantly greater than those available  to
the Company.

The  principal methods of competition in the market for PBBs  and
other   fine  chemicals  are  quality,  delivery  responsiveness,
customer  service  and  price.   The  Company  believes  that  it
competes  effectively in each of these areas.  The  Company  also
believes  that  its production of a wide range  of  products  and
quantities  gives it a competitive advantage in the  marketplace.
In  addition, the Company believes that pharmaceutical  companies
generally view internal production of PBBs as a misallocation  of
resources  and,  given a reliable source of  a  quality  product,
would rather obtain them from an outside supplier.

RESEARCH AND DEVELOPMENT

The Company's Research and Development Group is composed of seven
people,  of which three have graduate degrees in chemistry.   The
Company's  research  and  development efforts  focus  on  process
development  to  support the Company's  PBB  product  lines.   In
addition, the Group explores alternative scaleable routes for PBB
production, especially for its Specialty Amino Acids.

During the fiscal years ended March 31, 1999, 1998, and 1997, the
Company's   research  and  development  expenses  were  $338,000,
$215,000 and $211,000, respectively.  These figures, however,  do
not  completely  reflect the Company's research  and  development
activity since substantial process development efforts have  been
associated with initial orders for new products and, accordingly,
have  been expensed as cost of sales associated with the  product
revenue  rather than as a research and development expense.   The
Company  estimates  that  its combined research  and  development
effort  (including effort directly associated with  the  sale  of
product) was approximately $450,000, $419,000 and $346,000 during
the   fiscal  years  ended  March  31,  1999,  1998   and   1997,
respectively.

EMPLOYEES

As  of  May  21,  1999, the Company employed 54 individuals.   In
addition  to  production,  maintenance,  materials  handling  and
quality   control   personnel  essential  for  a  round-the-clock
operation, the Company added technical and professional staff  in
various  support functions during fiscal 1999.  In  keeping  with
the  growing  regulatory and compliance demands of the  industry,
Synthetech  also  added full-time coordinators in  the  areas  of
Quality Assurance and Environment, Health & Safety.

REGULATORY MATTERS

As   the  Company's  products  are  intermediates  sold  to  drug
manufacturers, the Company has been generally unaffected  by  FDA
regulation which is directed at the drug manufacturers.  The

<PAGE> 5

Company's  customers  do,  however,  typically  conduct  periodic
reviews  and  audits of the Company's operations,  including  its
inspection  and  quality  assurance  programs.   These   programs
involve   materials   tracking,   record   keeping   and    other
documentation.  As  some  customers have  begun  to  request  the
Company   to   manufacture  and  supply  PBBs   with   additional
processing, the Company expects these programs will often include
more  extensive documentation.  The Company anticipates that  the
expenses  of  implementing these programs will  increase  in  the
future.

The  Company's business is also subject to substantial regulation
in the areas of safety, environmental control and hazardous waste
management.  Although  the  Company  believes  that  it   is   in
compliance with these laws, rules and regulations in all material
respects,   the  failure  to  comply  with  present   or   future
regulations  could result in fines being imposed on the  Company,
suspension   of   production  or  cessation  of  operations.   As
additional  and  more extensive regulations are  being  added  in
these  areas  at  the  federal,  state  and  local  levels,   the
compliance  costs  will  inevitably continue  to  increase.   The
operation  of  fine  chemical manufacturing  plants  entails  the
inherent risk of environmental damage or personal injury  due  to
the handling of potentially harmful substances, and there can  be
no  assurance  that material costs and liabilities  will  not  be
incurred  in  the future because of an accident  or  other  event
resulting in personal injury or an unauthorized release  of  such
substances  to  the  environment.  Also,  the  Company  generates
hazardous and other wastes which are disposed of at various  off-
site  facilities.  The  Company may be  liable,  irrespective  of
fault,  for material cleanup costs or other liabilities  incurred
at  these  disposal facilities due to releases of such substances
into the environment.

The  Company  estimates that in fiscal 1999 and fiscal  2000,  it
will   undertake   capital  expenditures   aggregating   $700,000
associated  with air quality scrubbers, waste water handling  and
other environmental control facilities.

The   Company  maintains  property  damage  insurance,  liability
insurance,  environmental risk insurance, and  product  liability
insurance.

PRODUCT LIABILITY

Use   of  the  Company's  products  in  pharmaceuticals  and  the
subsequent  testing,  marketing and sale of such  pharmaceuticals
involves an inherent risk of product liability.  There can be  no
assurance that claims for product liability will not be  asserted
against  the  Company  or  that the  Company  would  be  able  to
successfully  defend any claim that may be asserted.   A  product
liability  claim  could  have a material adverse  effect  on  the
business and/or financial condition of the Company.  The  Company
maintains  product liability insurance with a $1  million  limit.
Also,  the  Company  maintains  an umbrella  liability  insurance
policy with an additional $9 million of coverage.

COMPANY BACKGROUND

The  Company was formed in 1981 to develop novel chemical process
technology by combining classical organic chemistry with  enzyme-
based  biocatalysis.  For the first several  years,  it  operated
mainly  as  a research and development group focused  on  process
development  of pharmaceuticals and other fine chemicals.   After
its  initial  public  offering in 1984,  the  Company's  research
efforts  were  concentrated on the development of  a  proprietary
process for

<PAGE> 5

aspartame and L-phenylalanine.   Although the Company has entered
into  one  license for this technology, the Company  discontinued
marketing  this technology in 1991 and does not expect additional
licensing revenue.

Throughout  its  development during the 1980s, the  Company  also
offered contract research services.  These research services were
typically   provided  to  pharmaceutical  clients  and  generally
involved  the  development of biocatalytic  processes  (that  is,
chemical  processes which are affected by the use of  enzymes  or
micro-organisms).  Since the end of fiscal 1990, the Company  has
phased  out  contract research services and does  not  anticipate
receiving any significant revenue from research services  in  the
future.   By  the end of the 1980s, the Company, building  on
prior  experience, began to focus on the production of  PBBs  and
other   fine   chemicals  for  customers.   With  the  successful
completion  of  the two large-scale orders in  fiscal  1999,  the
Company  has emerged as a leading producer of PBBs capable  of
full-cycle "grams to tons" production.

FACTORS AFFECTING FUTURE RESULTS

This   Annual   Report  on  Form  10-K  includes  forward-looking
statements (as defined in Section 21E of the Securities  Exchange
Act  of  1934, as amended).  Forward-looking statements  include,
without  limitation,  any statement that may  predict,  forecast,
indicate  or  imply future results, performance or  achievements,
and  may  contain  the  words "believe," "anticipate,"  "expect,"
"estimate,"  "project," "will be," "will continue," "will  likely
result"  or  words or phrases of similar meanings. Investors  are
cautioned  that  forward-looking  statements  involve  risks  and
uncertainties and various factors could cause actual  results  to
differ  materially  from the forward-looking  statements.   These
risks  and  uncertainties include, but are not  limited  to,  the
following:

     Uncertain  Market for Products; Customer Concentration;  and
Potential  Quarterly  Revenue  Fluctuations.   Historically,  the
Company  has experienced from time to time substantial period-to-
period  revenue fluctuations reflecting the industry  environment
in which the Company has operated.  The market for PBBs is driven
by  the  market  for the synthetically manufactured  peptide,
peptidomimetic small molecule and other  drugs  into which they are
incorporated.   The drug development process is dictated  by  the
marketplace, drug companies and the regulatory environment.   The
Company   has   no   control  over  the  pace  of   peptide,
peptidomimetic small molecule and other drug development, which
drugs  get selected  for  clinical trials, which drugs are approved
by  the Food and Drug Administration ("FDA"), and, even if approved,
the ultimate potential of such drugs.

     Recurring  sales  of PBBs for discovery  or  clinical  trial
stage  development  programs  is  sporadic  at  best.   The  high
cancellation  rate  for drug development programs  results  in  a
significant  likelihood  that there  will  be  no  subsequent  or
"follow-on"   PBB  sales  for  any  particular  drug  development
program.   Accordingly, the level of purchasing by the  Company's
customers   for   specific  drug  development   programs   varies
substantially  from year to year and the Company cannot  rely  on
any one customer as a constant source of revenue.

     Sales of PBBs for marketed drugs provide an opportunity  for
continuing  longer-term sales and the size of the PBB orders  for
marketed  drugs can be substantially larger than  those  for  the
discovery  or  clinical trial stages.  While not subject  to  the
same high cancellation rate faced by

<PAGE> 7

discovery  and clinical trial stage drug development  programs,
the  demand  for  the  approved drugs  remains  subject  to  many
uncertainties, including, without limitation, the drug price, the
drug  side  effects and the existence of other  competing  drugs.
These  factors, which are outside of the control of the  Company,
will  affect  the  level  of  demand for  the  drug  itself  and,
therefore, the demand for PBBs.

     Since  the Company's revenues are composed of PBB  sales  in
all  three drug development stages, and since even sales of  PBBs
for  marketed drugs are subject to cancellation or reduction, the
Company   is   likely  to  continue  to  experience   significant
fluctuations in its quarterly results.

     Industry Cost Factors.  The market for PBBs is dependent  on
the  market for pharmaceutical products.  The levels of  revenues
and profitability of pharmaceutical companies may be affected  by
the continuing efforts of governmental and third party payors  to
contain or reduce the cost of health care through various  means.
For example, in certain foreign markets, pricing or profitability
of prescription pharmaceuticals is subject to government control.
In  the  United States, there have been, and the Company  expects
that  there  will continue to be, a number of federal  and  state
proposals to implement similar government controls.  In addition,
in  both  the  United States and elsewhere, sales of prescription
pharmaceuticals  are  dependent in part on  the  availability  of
reimbursement  to the consumer from third party  payors  such  as
government  and private insurance plans.  Third party payors  are
increasingly challenging the prices charged for medical  products
and  services.   Peptide and peptidomimetic small molecule  drugs
may  not be considered cost effective, and reimbursement may  not
be  available or sufficient to allow these drugs to be sold on  a
profitable  basis.   In  addition,  as  cost  pressures  in   the
pharmaceutical industry have tightened, the cancellation rate for
drug development programs has increased.  Industry cost pressures
can   also   cause   pharmaceutical  companies   to   investigate
alternative  drug manufacturing processes which may  not  include
PBBs.

     Competition.   In  the  past, the  Company  has  not  had  a
significant  amount  of  direct  competition  for  discovery  and
clinical  trial  stage  drug development projects.   The  Company
believes that this resulted from peptide and peptidomimetic small
molecule drugs, particularly those which utilize synthetic  amino
acids,  being  relatively new and the market for PBBs  relatively
small.  As the market has continued to grow with multi-ton  order
sizes becoming more prevalent, the Company has begun to see  more
competition.   Current competition in the multi-kilo  or  smaller
quantities of natural amino acid based PBBs comes primarily  from
several European fine chemical companies.  Multi-ton order  sizes
of  these  natural PBBs have begun to attract a  wider  group  of
domestic  and international chemical companies.  In the  area  of
synthetic amino acid based PBBs, the Company has competition on a
selective  product basis from fine chemical producers  in  Europe
and Japan.

     Competition has also increased for supplying PBBs  for  drug
development  programs that reach late clinical  trials  and  move
into  an  approved  status  as a result of  increased  quantities
typically  required  at  these stages and pharmaceutical  company
requirements  to have second sources of material available.   The
Company's  competitors  have technical,  financial,  selling  and
other  resources available to them that are significantly greater
than those available to the Company.

     Regulatory Matters.  The Company is subject to a variety  of
federal,  state and local laws, rules and regulations related  to
the discharge or disposal of toxic, volatile or other hazardous

<PAGE> 8

chemicals.   Although  the  Company  believes  that  it   is   in
compliance with these laws, rules and regulations in all material
respects,   the  failure  to  comply  with  present   or   future
regulations  could result in fines being imposed on the  Company,
suspension  of  production  or cessation  of  operations.   Third
parties  may  also  have the right to sue to enforce  compliance.
Moreover,  it  is possible that increasingly strict  requirements
imposed by environmental laws and enforcement policies thereunder
could   require   the   Company  to  make   significant   capital
expenditures.   The  operation of a chemical manufacturing  plant
entails  the  inherent risk of environmental damage  or  personal
injury due to the handling of potentially harmful substances, and
there  can  be  no assurance that material costs and  liabilities
will  not  be  incurred in the future because of an  accident  or
other  event resulting in personal injury or unauthorized release
of  such substances to the environment.  In addition, the Company
generates hazardous materials and other wastes which are disposed
at  various  offsite  facilities.  The  Company  may  be  liable,
irrespective  of  fault,  for material  cleanup  costs  or  other
liabilities incurred at these disposal facilities in the event of
a  release  of hazardous substances by such facilities  into  the
environment.    The  Company  has  obtained  environmental   risk
insurance.

     Potential Regulation.  The PBBs produced by the Company  are
intermediate  ingredients  which  are  then  processed   by   the
companies to which they are sold, and are therefore currently not
subject  to the requirements of the FDA. The Company's  customers
do, however, typically conduct periodic reviews and audits of the
Company's  operations,  including  its  inspection  and   quality
assurance  programs.  These programs involve materials  tracking,
record  keeping and other documentation.  As some customers  have
begun to request the Company to manufacture and supply PBBs  with
additional  processing, the Company believes that these  programs
will   often  become  more extensive.  Accordingly,  the  Company
expects  its  compliance documentation efforts will  continue  to
increase  and anticipates that the expenses of implementing  such
programs  will increase in the future.  It is also possible  that
in the future that the Company may not be able to comply with the
applicable  documentation  or  such  documentation  may   require
substantial incremental expense for additional labor and capital.

     Product  Liability.   Use  of  the  Company's  products   in
pharmaceuticals and the subsequent testing, marketing and sale of
such   pharmaceuticals  involves  an  inherent  risk  of  product
liability.   Claims  for  product  liability  could  be  asserted
against  the  Company  and  the  Company  may  not  be  able   to
successfully  defend any claim that may be asserted.   A  product
liability  claim  could  have a material adverse  effect  on  the
business and/or financial condition of the Company.  The  Company
has  purchased  product  liability  insurance  with  a  limit  of
$1  million.   Also, the Company maintains an umbrella  liability
insurance policy with an additional $9 million of coverage.

     Risks of Technological Change.  The market for the Company's
products  is  characterized by rapid changes in both product  and
process technologies.  The Company's future results of operations
will  depend upon its ability to improve and market its  existing
products and to successfully develop, manufacture and market  new
products.  The Company may not be able to continue to improve and
market  its existing products or develop and market new products,
and technological developments could cause the Company's products
and technology to become obsolete or noncompetitive.

     Manufacturing  Capacity.   As a manufacturer  of  PBBs,  the
Company  will  continually face risks regarding the  availability
and costs of raw materials and labor, the potential need for

<PAGE> 9

additional capital equipment, increased maintenance costs, plant
and  equipment  obsolescence and quality  control.   In  November
1997,   the  Company  completed  construction  of  an  additional
manufacturing  facility on its site in Albany, Oregon.   In  this
first phase, processing equipment was installed in two of the six
bays.  In May 1998, the Company announced its decision to install
processing  equipment  in two additional bays  and  to  construct
additional  warehouse, bulk storage and related facilities.   The
Company  expects  that  this second phase will  be  completed  in
calendar  1999.   Completion  of the  second  phase  at  the  new
facility  could  be delayed and the existing facilities  may  not
have  sufficient  capacity to meet the demand for  the  Company's
products,  particularly in the event that several of the  peptide
and  peptidomimetic small molecule drugs for  which  the  Company
supplies  PBBs simultaneously become commercially successful.   A
disruption in the Company's production or distribution could have
a material adverse effect on the Company's financial results.  In
addition,  the Company may not have sufficient demand to  utilize
the additional capacity.

     Risks of International Business.  Sales to customers outside
the   United  States  accounted  for  approximately  28%  of  the
Company's net sales during the fiscal year ended March 31,  1999.
The  Company  expects that international sales will  continue  to
account for a significant percentage of net sales.  The Company's
business is and will be subject to the risks generally associated
with  doing business internationally, including changes in demand
resulting   from   fluctuations  in   exchange   rates,   foreign
governmental regulation and changes in economic conditions. These
factors,  among others, could influence the Company's ability  to
sell  its  products in international markets.  In  addition,  the
Company's sale of its products is  subject to  the  risks  associated
with legislation and regulation relating to imports, including quotas,
duties  or  taxes and other charges, restrictions and retaliatory
actions  on  imports in to other countries in which  the  Company's
products may be sold.  The Company is also subject to similar risks
with respect to the importation of raw materials from foreign countries.

     Year 2000 Compliance.  After review, the Company believes
that its information systems which support business  applications
and its research and development, manufacturing processes and
facility management systems currently are able to appropriately
interpret the calendar year 2000 ("Y2K") and subsequent years or
will be able to appropriately interpret Y2K and subsequent years
after certain upgrades are completed by the Summer of 1999.
While the Company does not believe it to be the case, there is a
risk that the Company's software applications will be unable to
appropriately interpret such years despite the installation of
these upgrades. The failure to correct a material Y2K problem
could result in an interruption in, or a failure of, certain
normal business activities or operations. Such failures could
materially and adversely affect the Company's results of
operations, liquidity and financial condition. Due to the general
uncertainty inherent in the Y2K issue, resulting in part from
the uncertainty of the Y2K readiness of third-party suppliers and
customers, the Company is unable to determine at this time
whether the consequences of Y2K failures will have a material
impact on the Company's results of operations, liquidity or
financial condition.

<PAGE> 10



                       ITEM 2.  PROPERTIES

Synthetech's headquarters and production facilities  are  located
in  Albany,  Oregon.  In 1987, the Company purchased the  Albany,
Oregon  property  which included a 23,000 square  foot  facility.
This   original   facility   houses  production,   pilot   plant,
laboratory,  warehouse and office space.  In November  1997,  the
Company completed the construction of an additional 20,000 square
foot production facility on the Albany, Oregon property.

The  completion of this additional two-story production  facility
substantially  increases the Company's capacity to  produce  PBBs
and other fine chemicals.  This facility has six production bays.
Two of the bays are outfitted with manufacturing equipment and are
in production.  On May 28, 1998, the Company announced its  decision
to  outfit  two  more  bays.   The  Company  expects  that  these
additional  two  bays will be completed during Summer  1999.  The
final two bays remain vacant and available for future expansion.

In  the initial construction of the building and the build out of
the  bays,  Synthetech has contracted with  various  third  party
providers.   The  Company  has issued  purchase  orders  to  such
providers  with detailed specifications, services to be  provided
and  the  prices  to  be paid.  The Company has  received  either
limited  or  no written warranties by such third party  providers
and,  therefore, may be limited in its ability to pursue remedies
in  the event that the new building has problems or other defects
in  the future.  However, the building has been inspected by  the
City  of  Albany  to verify that, as constructed,  it  meets  all
applicable  building  codes, including ADA, electrical,  seismic,
fire  and  hazardous occupancy.  All specifications were reviewed
by  an  independent third-party engineering firm selected by  the
City of Albany prior to approval of various construction permits.



                   ITEM 3.  LEGAL PROCEEDINGS

Not applicable.

<PAGE> 11

ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

Not applicable.



                             PART II

        ITEM 5.  MARKET FOR REGISTRANT'S COMMON STOCK AND
                   RELATED SHAREHOLDER MATTERS

The  Company's Common Stock trades on the Nasdaq National Market.
The  Company's  common  stock  trading  symbol  is  "NZYM."   The
following table sets forth the range of high and low sales prices
for the Common Stock for the last two fiscal years as reported by
Nasdaq.

                        Fiscal Year Ended March 31,
                        ---------------------------
                        1999                   1998

                  High        Low         High        Low
                  ----        ---         ----        ---
     First
     Quarter     $8.00       $6.00       $9.38       $6.25

     Second
     Quarter      7.00        3.38        7.88        5.19

     Third
     Quarter      7.13        3.38        6.88        5.25

     Fourth
     Quarter      6.50        4.00        6.38        4.50
___________________________

No  dividends on the Company's Common Stock have been paid  since
inception and the Company does not anticipate that dividends will
be  paid in the foreseeable future.  The number of record holders
of Common Stock as of May 24, 1999 was 684.

<PAGE> 12

                ITEM 6.  SELECTED FINANCIAL DATA

The  following  statements of income data for each  of  the  five
years ended March 31, 1999 and the selected balance sheet data as
of  March 31, 1995 through 1999, as set forth below, were derived
from   the  Company's  financial  statements  audited  by  Arthur
Andersen  LLP.  The following data should be read in  conjunction
with  "Item 8.  Financial Statements And Supplementary Data"  and
"Item  7.   Management's  Discussion and  Analysis  of  Financial
Condition and Results of Operations" included elsewhere herein.

<TABLE>
<CAPTION>
<S>                           <C>       <C>       <C><C>         <C>

                                           Year Ended March 31,
                                 1999     1998     1997     1996      1995
                                (in thousands, except per share data)

     STATEMENTS OF INCOME DATA:
     Revenues                  $ 23,133 $  8,321 $ 12,797 $  8,472  $  5,357

     Gross Profit                10,150    3,001    7,694    4,787     2,759
     Operating Income             8,341    1,611    6,248    3,737     1,816

     Net Income                $  5,418 $  1,221 $  4,112 $  2,574  $  1,415

     Basic Earnings Per Share     $0.38    $0.09    $0.30    $0.21     $0.12
     Diluted Earnings Per Share   $0.38    $0.09    $0.29    $0.19     $0.11


                                                   March 31,
                                 1999      1998     1997      1996      1995
                                                 (in thousands)

     BALANCE SHEET DATA:
     Working Capital          $ 12,110  $  8,237  $  9,242 $  8,157 $  3,574

     Total Assets               26,230    19,364    17,323   10,959    6,661
     Long-Term Debt                152       166       180        -        -
     Retained Earnings          14,349     8,931     7,710    3,598    1,024
     Shareholders' Equity     $ 23,027  $ 17,306  $ 15,797 $ 10,100 $  6,259
</TABLE>

<PAGE> 13


        ITEM 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF
          FINANCIAL CONDITION AND RESULTS OF OPERATIONS


RESULTS OF OPERATIONS

The  following  table sets forth, for the periods indicated,  the
percentage of revenues represented by each item included  in  the
Statements of Income.
<TABLE>
<CAPTION>
<S>                      <C>            <C>       <C>

                               Percentage of Revenues
                             Fiscal Year Ended March 31,
                             ---------------------------
                               1999     1998      1997
                               ----     ----      ----
Revenues                      100.0%   100.0%    100.0%
Cost of Sales                  56.1%    63.9%     39.9%
                              ------   ------    ------
Gross Profit                   43.9%    36.1%     60.1%

Research and Development        1.5%     2.6%      1.6%
Selling, general and
 administrative                 6.4%    14.1%      9.7%
                              ------  -------   -------
Operating Income               36.0%    19.4%     48.8%

Other Income                    0.9%     3.7%      3.0%
Interest Expense               (0.1)%      -         -
                              ------   ------    ------
Income Before Income Taxes     36.8%    23.1%     51.8%

Provision for Income Taxes     13.5%     8.4%     19.7%
                              ------   ------    ------
Net Income                     23.3%    14.7%     32.1%
                              ======   ======    ======

Revenues
- --------
Synthetech  revenues  were  $23.13  million,  $8.32  million  and
$12.80  million  in  fiscal 1999, fiscal 1998  and  fiscal  1997,
respectively,  reflecting the unpredictability and potential  for
significant  revenue fluctuations associated  with  the  industry
environment  in which the Company operates. The 178% increase  in
revenues  in fiscal 1999 as compared to fiscal 1998 and  the  35%
decrease  in  revenues in fiscal 1998 as compared to fiscal  1997
primarily  reflected the impact of large-scale  orders.  Revenues
from  large-scale orders were $14.14 million, $2.17  million  and
$8.07  million  for  fiscal 1999, fiscal 1998  and  fiscal  1997,
respectively.  In fiscal 1999, there were two large-scale  orders
totaling  $10.18 million and $3.96 million of revenue during  the
year.  These  two  PBB orders for marketed drugs  were  initially
received  in  the  third quarter of fiscal 1998  and  represented
$879,000  and $1.29 million of the fiscal 1998 large-scale  order
revenue. The fiscal

<PAGE> 14

1997 large-scale order revenue was attributable to PBBs for three
drugs in clinical trials. All revenues during fiscal 1999, fiscal
1998 and fiscal 1997 represented sales of PBBs.

Synthetech  had record revenues in fiscal 1999. Fiscal  1999  was
also  the  first year in which PBB production for marketed  drugs
represented  over  half  of  the Company's  annual  revenue.  The
Company  estimates that in fiscal 1999 approximately 63%  of  the
Company's  PBB sales went into marketed drugs, approximately  33%
went  into  drugs  in  clinical or late pre-clinical  trials  and
approximately  4% went into drugs at the R&D or discovery  stage.
In  fiscal  1998  and  fiscal 1997, the  Company  estimates  that
approximately  46%  and 11%, respectively, of the  Company's  PBB
sales  went  into  marketed  drugs, approximately  41%  and  83%,
respectively,  went into drugs in clinical or  late  pre-clinical
trials  and  approximately 13% and 6%,  respectively,  went  into
drugs at the R&D or discovery stage. These estimates are based on
an  analysis of the Company's sales and information to the extent
available from customers.

Synthetech's  fiscal  1999 large-scale production  confirmed  the
Company's capability to produce PBBs at the higher volumes  often
associated  with  marketed  drugs. Combined  with  the  Company's
already  well  established production capability at the  research
and  clinical testing stages, the Company has demonstrated a full
cycle  "grams  to  tons" production capability. This  full  cycle
capability  reinforces  Synthetech's  long-term  growth  strategy
emphasizing  a commitment to its customers from the early  phases
of  discovery  through clinical development  and  culminating  in
marketed  drugs. In fact, the two fiscal 1999 large-scale  orders
exemplify this strategy: the Company had supplied  PBBs for  both
of these drugs since their early clinical development stages.

The   level  of  Synthetech's  business  from  period  to  period
continues  to  be unpredictable to a large extent.  Although  PBB
sales associated with marketed drugs are more likely to provide a
longer  term,  ongoing revenue stream than sales associated  with
drugs  at  the  discovery  or  clinical  stage,  continuation  of
customer  demand for PBBs associated with marketed drugs  remains
subject   to   various  market  conditions,  including,   without
limitation,  potential  use of alternative manufacturing  routes,
competition  from  other suppliers of PBBs and  continued  market
demand  for  the  drug.  For example, the customer  to  whom  the
Company  shipped  $10.18 million in fiscal 1999  PBB  orders  has
advised the Company that it is adopting an alternative lower-cost
manufacturing route not using Synthetech's PBB.  Synthetech  does
not  expect  any additional orders for this product from this
customer  after  the current  order is completed by the summer of
1999.   Accordingly, while large-scale orders for  marketed  drugs
can   provide significant  and  predictable revenues for the
duration  of  the orders,  there  continues to be a significant
risk that  revenues can  fluctuate  from  period  to period.
The  timing  of  order placement also affects the Company's revenues.
The other large-scale customer placed its fiscal 1999 PBB orders to
coincide  with  its  own  drug  production  schedule.   While Synthetech
believes that it will receive additional orders  from this  customer,
the timing and extent of the customer's next drug production  campaign,
and thus the order for PBBs, has  not  been finalized.

With  this industry environment, it is difficult to predict  with
certainty the level of future business. Nevertheless, the Company
has   a   sizable   backlog  of  PBB  orders   of   approximately
$8.86  million  at  March 31, 1999. Less than  a  third  of  this
backlog ($2.99 million) represents the final shipments under  the
discontinued  large-scale order discussed above. The  balance  of
the  backlog  ($5.87 million) represents a diverse  set  of  PBBs
including  several  novel PBBs for a handful of  drugs  advancing
through the clinical pipeline. If these continue to progress and

<PAGE> 15

Synthetech  remains  a primary PBB supplier,  they  could  have
significant  future business potential. There are, however,  many
factors,  most of which are outside the control of  the  Company,
affecting  the success of these drug candidates and  Synthetech's
involvement. (See "Industry Factors" below.)

Gross Profit
- ------------
Gross  profit was $10.15 million, $3.00 million and $7.70 million
in  fiscal 1999, fiscal 1998 and fiscal 1997, respectively.  This
reflects  a 238.0% increase in gross profit in fiscal  1999  from
fiscal 1998, and a 61.0% decrease in gross profit in fiscal  1998
from  fiscal  1997.  As  a percentage of revenues,  gross  profit
margins  were 43.9%, 36.1% and 60.1% in fiscal 1999, fiscal  1998
and fiscal 1997, respectively.

The  gross profit margins for fiscal 1999 resulted primarily from
the  mix  of products (i.e., type and volume of products sold  as
individual  orders)  and  this  year's  closely  associated  high
revenue  levels.  Revenues  from large-scale  PBB  orders  during
fiscal  1999  represented 61.1% of total revenue for the  period.
While   large-scale  orders  for  marketed  drugs   can   provide
significant  revenues  for  the  duration  of  the  orders,  they
typically generate a lower gross profit margin than the  sale  of
smaller  quantities  of  the same PBB  product  during  the  drug
discovery and clinical stages. The Company, however, continuously
seeks  to improve the gross profit margins of large-scale  orders
through process improvements and operating efficiencies.

Gross  profit margins for fiscal 1998 reflected a combination  of
factors:   a low level of revenues resulting from the absence  of
large-scale projects until the end of the third quarter of fiscal
1998; the increased manufacturing overhead costs as the new plant
facility  came online in fiscal 1998; costs associated  with  the
start up and early process development at the new plant facility;
and the product mix in fiscal 1998.

Fiscal  1997  gross profit margins reflected significant  revenue
levels,  a  high  margin product mix and the lower  manufacturing
overhead costs prior to the new plant facility coming online.

The  Company  expects revenues and product  mix  to  continue  to
fluctuate  from  period to period and cause  variation  in  gross
profit margins.

Operating Expenses
- ------------------
Research and development (R&D) expense increased to $338,000,  or
1.5%  of sales, in fiscal 1999, from $215,000, or 2.6% of  sales,
in  fiscal  1998.  R&D expense was $211,000, or 1.6%,  in  fiscal
1997.  These  figures,  however, do not  completely  reflect  the
Company's  research  and development activity  since  substantial
process  development  efforts have been associated  with  initial
orders  for new products and, accordingly, have been expensed  as
cost of sales associated with the product revenue rather than  as
a  research  and development expense. The Company estimates  that
its  combined  research and development effort (including  effort
directly  associated with the sale of product) was  approximately
$450,000,  $419,000  and $346,000 during the fiscal  years  ended
March 31, 1999, 1998 and 1997, respectively.

Selling,   general   and  administrative   (SG&A)   expense   was
$1.47  million, $1.18 million and $1.24 million in  fiscal  1999,
fiscal  1998 and fiscal 1997, respectively. The increase in  SG&A
in  fiscal  1999  from fiscal 1998 primarily reflected  increased
labor costs (as described below) and

<PAGE> 16

payments  made  under an agreement with a former officer  of  the
Company.  The  decrease in SG&A in fiscal 1998 from  fiscal  1997
primarily reflected a reduced employee bonus pool in fiscal  1998
as  the staffing level in this area remained relatively constant.
SG&A as a percentage of sales was 6.4%, 14.1% and 9.7% for fiscal
1999, fiscal 1998 and fiscal 1997, respectively.

Operating Income
- ----------------
Operating income was $8.34 million in fiscal 1999, $1.61  million
in  fiscal 1998 and $6.25 million in fiscal 1997. In fiscal 1999,
Company-wide  labor  costs (including the  employee  bonus  pool)
(hereinafter  "labor  costs") increased  to  $2.48  million  from
$1.50  million in fiscal 1998. Commencing in the second  half  of
fiscal  1998  and  continuing in fiscal 1999, the  Company  hired
additional  employees in connection with its plant expansion  and
overall  Company growth. The increase in labor  costs  in  fiscal
1999  reflected this hiring program. In addition,  the  Company's
fiscal 1999 employee bonus pool was significantly higher than the
fiscal year 1998 pool, reflecting fiscal 1999's record results.

Fiscal  1998  labor  costs of $1.5 million  were  less  than  the
$1.82  million of labor costs in fiscal 1997. While  the  Company
hired additional employees during fiscal 1998 in connection  with
its  plant  expansion, the reduction in the employee  bonus  pool
paid  during  fiscal 1998 as compared to fiscal  1997  more  than
offset  the hiring increase, causing the net reduction  in  labor
costs.

As a percentage of revenues, operating income was 36.0% in fiscal
1999, 19.4% in fiscal 1998 and 48.8% in fiscal 1997.

Other Income
- ------------
The  $215,000 net other income in fiscal 1999 resulted  primarily
from $275,000 of interest earnings less miscellaneous expenses of
$60,000.  The $312,000 net other income in fiscal 1998  primarily
resulted  from  $294,000  of  interest  earnings  and  a  $25,000
recognized gain from the sale of securities available  for  sale.
The  $385,000 net other income in fiscal 1997 primarily  resulted
from $376,000 of interest earnings.

Near  the  end of fiscal 1997, the Company incurred  $194,000  in
wastewater  system development charges assessed by  the  City  of
Albany in connection with the Company's plant expansion. This fee
plus  interest  on  the  unpaid portion  is  payable  in  monthly
payments of approximately $2,500 through February 2008.

Net Income
- ----------
In  fiscal  1999, the Company earned $8.54 million before  income
taxes. A provision for income taxes of $3.12 million resulted  in
net  income of $5.42 million. In fiscal 1998, the Company  earned
$1.92  million before income taxes. A provision for income  taxes
of  $702,000 resulted in net income of $1.22 million.  In  fiscal
1997,  the  Company earned $6.63 million before income  taxes.  A
provision  for  income  taxes of $2.52 million  resulted  in  net
income  of $4.11 million. The effective tax rates for the Company
were  relatively flat between years at 36.5%, 36.5%  and  38%  in
fiscal 1999, fiscal 1998 and fiscal 1997, respectively.

<PAGE> 17

INDUSTRY FACTORS

The  market  for  PBBs is driven by the market for  synthetically
manufactured peptide, peptidomimetic small molecule and other drugs
in which  they  are incorporated. The drug development  process  for
these  drugs  is dictated by the marketplace, drug companies  and
the  regulatory environment. The Company has no control over  the
pace  of these drug development efforts, which drugs get selected
for  clinical  trials, which drugs are approved by the  FDA  and,
even if approved, the ultimate market potential of such drugs.

The three stages of the drug development process include:  R&D or
discovery  stage, clinical trial stage and marketed  drug  stage.
Synthetech's customers can spend years researching and developing
new  drugs, taking only a small percentage to clinical trials and
fewer  yet  to  commercial market. A substantial  amount  of  the
activity continues to occur at the earlier stages of research and
development  and  clinical trials. The  market  for  peptide  and
peptidomimetic  small  molecule drugs  is  still  very  early  in
development.

Recurring  sales of PBBs for development programs is sporadic  at
best.  The  high cancellation rate for drug development  programs
results  in  a  significant likelihood  that  there  will  be  no
subsequent  or  "follow-on" PBB sales  for  any  particular  drug
development program. Accordingly, the level of purchasing by  the
Company's customers for specific drug development programs varies
substantially from quarter to quarter and the Company cannot rely
on any one customer as a constant source of revenue.

The   size  of  the  PBB  orders  for  marketed  drugs   can   be
substantially  larger  than those for the discovery  or  clinical
trial  stages. Sales of PBBs for marketed drugs can also  provide
an  opportunity  for  continuing  longer-term  sales.  While  not
subject to the same high cancellation rate faced by discovery and
clinical  trial stage drug development programs, the  demand  for
the   approved   drugs,   however,  remains   subject   to   many
uncertainties, including, without limitation, the drug price, the
drug  side  effects and the existence of other  competing  drugs.
These  factors, which are outside of the control of the  Company,
will  affect  the  level  of  demand for  the  drug  itself  and,
therefore, the demand for PBBs. Also, industry cost pressures can
cause  pharmaceutical companies to explore and, as was  the  case
with  one of the fiscal 1999 large-scale orders, ultimately adopt
alternative  manufacturing processes which  do  not  include  the
Company's PBBs as an intermediate. Finally, with the longer-term,
larger-scale orders, the Company expects increased competition to
supply these PBBs.

Accordingly, these industry factors create an inability  for  the
Company  to predict future demand beyond its current order  base.
Until  the  Company  develops a stable baseload  of  demand,  the
Company   is   likely  to  continue  to  experience   significant
fluctuations in its quarterly results.

LIQUIDITY AND CAPITAL RESOURCES

At   March   31,  1999,  the  Company  had  working  capital   of
$12.11  million compared to $8.24 million at March 31, 1998.  The
Company's  cash  and cash equivalents at March 31,  1999  totaled
$7.47  million, a $2.49 million increase from the March 31,  1998
level.  This  increase  reflected the higher  level  of  revenues
during fiscal 1999 compared to fiscal 1998.  The Company does not
invest in derivative securities.  Capital expenditures associated
with  phase two of the plant expansion and upgrades  to  the
existing plant were more than offset by cash from operations

<PAGE> 18

in  fiscal  1999. Looking forward to fiscal 2000,  the  Company
expects its capital expenditures to be similar to the fiscal 1999
level  and,  accordingly,  the  change  to  its  working  capital
position in fiscal 2000 will be largely affected by the level  of
cash  provided by operating activities. In addition, the  Company
has  a $1,000,000 unsecured bank line of credit. As of  March 31,
1999 there was no amount outstanding under the bank line.

The increase in accounts receivable to $3.41 million at March 31,
1998,  from $1.47 million at March 31, 1998, reflected the higher
level  of  revenues in the fourth quarter of fiscal 1999 compared
to the fourth quarter in the prior year. The increase in accounts
payable to $1.53 million at March 31, 1999 from $672,000 at March
31,  1998  was  primarily  the result of expenditure  commitments
related  to the second phase of the plant expansion and increased
raw  material  purchases. The decrease  in  deferred  revenue  to
$44,000  at  March  31,  1999 from $247,000  at  March  31,  1998
resulted from shipments against customer advance payments.

In  November 1997, the Company completed the 20,000 square  foot,
two-story  new building plant expansion project. In this  initial
phase, the Company completed the building structure and built out
two   of  the  six  production  bays.  The  overall  engineering,
construction  and equipment costs for this project  spanning  one
and one-half years were approximately $8.23 million. In the first
quarter  of fiscal 1999, the Company announced that its Board  of
Directors  had  approved a $5 million second-phase  expansion  to
outfit  two  more  bays  of the new plant  with  four  additional
multipurpose  reactor  systems and to construct  warehouse,  bulk
storage and related facilities. During fiscal 1999, the Company's
capital  expenditures were $3.47 million, $2.80 million of  which
were  for the second phase plant expansion and $674,000  for  the
existing plant and equipment upgrades.

During fiscal 2000, the Company estimates that $2.2 million  will
be  used to complete the second-phase plant expansion and  up  to
$1.3  million  will  be  used for existing  plant  and  equipment
upgrades.   The   Company  expects  to  finance   these   capital
expenditures from operating cash flow and reserves and  does  not
anticipate a need for any new debt or equity financing.

The  Company  owns  its facility and all of  its  equipment.  See
Note D to Financial Statements for a description of the Company's
property, plant and equipment.



YEAR 2000

The  Year  2000  ("Y2K") issue arose as the  result  of  existing
computer programs that use only the last two digits to refer to a
year.  Any  of  the Company's computer programs that  have  date-
sensitive  software may recognize a date using "00" as  the  year
1900  rather than the year 2000. If not corrected, many  computer
applications could fail or create erroneous results.

The  Company  has  established a  Y2K  team  lead  by  its  Chief
Financial Officer. The team has completed its assessment  of  the
Company's    information   systems   which    support    business
applications.   The   Company   utilizes   packaged   application
strategies  for these information systems functions. The  Company
believes  that  these information system components  are  current
with  all  Y2K  updates and changes recommended by  the  vendors.
These  information systems include enterprise software, operating
systems, networking components, application and data servers, PC

<PAGE> 19

hardware and core office automation software. The team has also
completed   its   assessment  of  the  Company's   research   and
development,  manufacturing  processes  and  facility  management
systems.  The Company believes that these systems and  components
are  current,  or  will be current by the end of September  1999,
with all Y2K updates and changes recommended by the vendors.  The
Company  is  undertaking a Y2K supplier and  customer  assessment
program.  It  is in the process of contacting key  suppliers  and
customers to determine the level of their Y2K readiness.

The Company's information technology expenditures for fiscal 1999
were $90,000, of which approximately 22% related to the Company's
Y2K  program.  These  expenses were paid  out  of  revenues  from
operations.  In connection with its responsibility to undertake a
Y2K  program,  the  Company has hired an  outside  consultant  to
provide  limited advice to the Company's Y2K team  and  Board  of
Directors  on the Company's Y2K program.  The Company has   hired
another  outside consultant to assist the Company's Y2K  team  in
developing and running certain Y2K on-site testing protocols. The
Company  expects that these activities will be completed  by  the
end   of   Summer  1999  and  has  budgeted  $20,000  for   these
consultants.

Like  all  businesses, the Company will be at risk from  external
infrastructure failures that could arise from Y2K failures. It is
not clear that electrical power, telephone and computer networks,
for  example, will be fully functional across the nation  in  the
year  2000. Investigation and assessment of infrastructures, like
the nations' power grid, is beyond the scope and resources of the
Company.  Investors should use their own awareness of the  issues
in  the  nations'  infrastructure to make ongoing  infrastructure
risk  assessments  and  their potential  impact  to  a  company's
performance.

It  should  also  be  noted that there have been  predictions  of
failures  of  key components in the transportation infrastructure
due to the Y2K issue. It is possible that there could be delays
in  rail,  over-the-road  and air shipments  due  to  failure  in
transportation control systems. Investigation and  validation  of
the world's transportation infrastructure is beyond the scope and
the  resources  of the Company. Investors should  use  their  own
awareness  of the issues in the nations' infrastructure  to  make
ongoing  infrastructure  risk  assessments  and  their  potential
impact to a company's performance.

The failure to correct a material Y2K problem could result in  an
interruption  in,  or  a  failure  of,  certain  normal  business
activities  or  operations. Such failures  could  materially  and
adversely  affect the Company's results of operations,  liquidity
and  financial condition. Due to the general uncertainty inherent
in the Y2K issue, resulting in part from the uncertainty of the
Y2K readiness of third-party suppliers and customers, the Company
is  unable to determine at this time whether the consequences  of
Y2K failures will have a material impact on the Company's results
of  operations, liquidity or financial condition.  The  Company's
efforts   to  help  ensure  Y2K  preparedness  are  expected   to
significantly reduce the Company's level of uncertainty about the
Y2K  issue. The Company believes that, with completion  of  the
above-mentioned system upgrades and testing, the  possibility  of
significant interruptions of normal operations should be reduced.

During  the Summer of 1999, Company intends to determine whether,
and to what extent, to develop contingency plans in regard to Y2K
issues.  the  Company expects to have completed  any  contingency
plans that it decides to undertake by the end of Fall 1999.

<PAGE> 20


     ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT
                           MARKET RISK

Not applicable.

<PAGE> 21


      ITEM 8.  FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA





                      Index                                             Page
                      -----                                             ----
Report of Independent Public Accountants for the years ended
 March 31, 1999, 1998 and 1997.....................................      23

Financial Statements:

  Balance Sheets as of March 31, 1999 and 1998.....................      24

  Statements of Income for the years ended March 31, 1999,
   1998 and 1997...................................................      26

  Statements of Shareholders' Equity and Comprehensive Income for
   the years ended March 31, 1999, 1998 and 1997...................      27

  Statements of Cash Flows for the years ended March 31, 1999, 1998,
   and 1997........................................................      28

Notes to Financial Statements:

  Note A - General and Business....................................      29

  Note B - Summary of Significant Accounting Policies..............      29

  Note C - Inventories.............................................      32

  Note D - Property, Plant and Equipment...........................      32

  Note E - Income Taxes............................................      33

  Note F - Line of Credit..........................................      33

  Note G - Note Payable............................................      34

  Note H - Shareholders' Equity....................................      34

  Note I - 401(k) Profit Sharing Plan..............................      37

  Note J - Segment Information.....................................      38

<PAGE> 22

REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS

To the Board of Directors and Shareholders of Synthetech, Inc.:

We  have  audited the accompanying balance sheets of  Synthetech,
Inc.  (an Oregon corporation) as of March 31, 1999 and 1998,  and
the  related  statements  of  income,  shareholders'  equity  and
comprehensive income, and cash flows for each of the three  years
in  the  period ended March 31, 1999.  These financial statements
are   the  responsibility  of  the  Company's  management.    Our
responsibility  is  to  express an  opinion  on  these  financial
statements based on our audits.

We  conducted  our  audits in accordance with generally  accepted
auditing  standards.  Those standards require that  we  plan  and
perform  the  audit to obtain reasonable assurance about  whether
the  financial statements are free of material misstatement.   An
audit  includes  examining, on a test basis, evidence  supporting
the  amounts  and  disclosures in the financial  statements.   An
audit also includes assessing the accounting principles used  and
significant  estimates made by management, as well as  evaluating
the  overall  financial statement presentation.  We believe  that
our audits provide a reasonable basis for our opinion.

In  our  opinion,  the  financial statements  referred  to  above
present  fairly, in all material respects, the financial position
of  Synthetech,  Inc.  as of March 31, 1999  and  1998,  and  the
results  of  its operations and its cash flows for  each  of  the
three years in the period ended March 31, 1999 in conformity with
generally accepted accounting principles.


Arthur Andersen LLP
Portland, Oregon,
May 14, 1999

<PAGE> 23

                                       SYNTHETECH, INC.

                                        BALANCE SHEETS
                                       ----------------

</TABLE>
<TABLE>
<CAPTION>
<S>                                         <C>             <C>

At March 31,                                    1999            1998
- ------------                                    ----            ----
 ASSETS
- ------------
CURRENT ASSETS:
  Cash and cash equivalents                  $ 7,470,000     $ 4,976,000
  Accounts receivable, less allowance
    for doubtful accounts of $15,000 for
    1999 and 1998                              3,414,000       1,470,000
  Inventories                                  3,359,000       3,184,000
  Prepaid expenses                               284,000         196,000
  Deferred income taxes                          133,000          70,000
  Other current assets                             5,000          24,000
                                            ------------    ------------
    TOTAL CURRENT ASSETS                      14,665,000       9,920,000


PROPERTY, PLANT AND EQUIPMENT, at cost, net   11,561,000       9,439,000

OTHER ASSETS                                       4,000           5,000
                                            ------------    ------------
    TOTAL ASSETS                            $ 26,230,000    $ 19,364,000
                                            ============    ============
See Notes to Financial Statements.
</TABLE>

<PAGE> 24

                                        SYNTHETECH, INC.

                                         BALANCE SHEETS
                                        ----------------
<TABLE>
<CAPTION>
<S>                                          <C>             <C>

At March 31,                                    1999           1998
- -------------------------------------           ----           ----
 LIABILITIES AND SHAREHOLDERS' EQUITY
- -------------------------------------
CURRENT LIABILITIES:
  Current portion of note payable          $     15,000    $    14,000
  Accounts payable                            1,543,000        672,000
  Accrued compensation                          375,000        221,000
  Deferred revenue                               44,000        247,000
  Accrued income taxes                          561,000        514,000
  Other accrued liabilities                      17,000         15,000
                                            -----------     ----------
    TOTAL CURRENT LIABILITIES                 2,555,000      1,683,000

DEFERRED INCOME TAXES                           496,000        209,000

NOTE PAYABLE, net of current portion            152,000        166,000

SHAREHOLDERS' EQUITY:
  Common stock, $.001 par value;
   authorized 100,000,000 shares; issued
   and outstanding, 14,252,000 and
   14,143,000 shares                             14,000         14,000
  Paid-in capital                             8,740,000      8,467,000
  Deferred  compensation                        (76,000)      (106,000)
  Retained earnings                          14,349,000      8,931,000
                                           ------------    -----------
    TOTAL SHAREHOLDERS' EQUITY             $ 23,027,000   $ 17,306,000
                                           ------------   ------------
    TOTAL LIABILITIES AND
     SHAREHOLDERS' EQUITY                  $ 26,230,000   $ 19,364,000
                                           ============   ============
See Notes to Financial Statements.
</TABLE>

<PAGE> 25


                                         SYNTHETECH, INC.

                                       STATEMENTS OF INCOME
                                       --------------------
<TABLE>
<CAPTION>
<S>                           <C>              <C>            <C>
For The Year Ended March 31,       1999             1998           1997
                                   ----             ----           ----

REVENUES                       $ 23,133,000     $  8,321,000    $ 12,797,000
COST OF SALES                    12,983,000        5,320,000       5,103,000
                               ------------     ------------    ------------
GROSS PROFIT                     10,150,000        3,001,000       7,694,000
                               ------------     ------------    ------------

Research and development            338,000          215,000         211,000
Selling, general and
 adminsitrative                   1,471,000        1,175,000       1,235,000
                               ------------     ------------     -----------
OPERATING EXPENSE                 1,809,000        1,390,000       1,446,000
                               ------------     ------------     -----------
OPERATING INCOME                  8,341,000        1,611,000       6,248,000

OTHER INCOME, net                   215,000          312,000         385,000
INTEREST EXPENSE                    (17,000)               -          (1,000)
                               ------------     ------------     -----------
INCOME BEFORE INCOME TAXES        8,539,000        1,923,000       6,632,000

PROVISION FOR INCOME TAXES        3,121,000          702,000       2,520,000
                               ------------     ------------      ----------
NET INCOME                     $  5,418,000     $  1,221,000    $  4,112,000
                               ============     ============    ============

BASIC EARNINGS PER SHARE              $0.38            $0.09           $0.30
                                      =====            =====           =====

DILUTED EARNINGS PER SHARE            $0.38            $0.09           $0.29
                                      =====            =====           =====
See Notes to Financial Statements.
</TABLE>

<PAGE> 26




                                         SYNTHETECH, INC.

                 STATEMENTS OF SHAREHOLDERS' EQUITY AND COMPREHENSIVE INCOME
                 -----------------------------------------------------------
<TABLE>
<CAPTION>
<S>                            <C>         <C>        <C>       <C>        <C>         <C>         <C>
                                                                EMPLOYEE
                                                                  NOTES
                                    COMMON STOCK                RECEIVABE   CUMULATIVE
                                -------------------  PAID-IN   & DEFERRED  COMPREHENSIVE RETAINED
                                 SHARES      AMOUNT   CAPITAL  COMPENSATION INCOME(LOSS) EARNINGS      TOTAL
                                ----------   ------- ---------- ----------  ----------- ----------  -----------    -----------
BALANCE, March 31, 1996         13,475,000   $13,000 $6,589,000 ($130,000)    $30,000   $3,598,000  $10,100,000
                                                                                                      ---------
Unrealized loss on securities
 available for sale                      -       -            -         -     (14,000)           -      (14,000)
Net income                               -       -            -         -           -    4,112,000    4,112,000
                                                                                                      ---------
Comprehensive income                     -       -            -         -           -            -    4,098,000
Issuance of stock for the
 exercise of stock options         260,000   1,000      322,000         -           -            -      323,000
Issuance of stock for the
 exercise of stock warrants        125,000       -      228,000         -           -            -      228,000
Issuance of below-market stock
 options                                 -       -      284,000   (284,000)         -            -            -
Amortization of deferred
 compensation                            -       -            -    125,000          -            -      125,000
Payment on employee note
 receivable                              -       -            -     50,000          -            -       50,000
Income tax benefit of exercise
 of stock warrants                       -       -      216,000          -          -            -      216,000
Income tax benefit of
 disqualifying dispositions              -       -      657,000          -          -            -      657,000
                                ----------  ------    ---------   --------     ------    ---------   ----------
BALANCE, March 31, 1997         13,860,000  14,000    8,296,000   (239,000)     16,000    7,710,000  15,797,000
                                                                                                    ----------
Realized loss on securities
 available for sale                      -        -            -          -    (16,000)           -     (16,000)
Net income                               -        -            -          -          -    1,221,000   1,221,000
                                                                                                      ---------
Comprehensive income                     -        -            -          -          -             -   1,205,000
Issuance of stock for the
 exercise of stock options         283,000        -      280,000          -          -             -     280,000
Issuance of below-market stock
 options                                 -        -       21,000    (21,000)         -             -           -
Amortization of deferred
 compensation                            -        -            -    124,000          -             -     124,000
Payment on employee note
 receivable                              -        -            -     30,000          -             -      30,000
Revision on estimate of income
 tax benefit on disqualifying
 dispositions                            -         -    (207,000)         -           -             -   (207,000)
Income tax benefit of
 disqualifying dispositions              -         -      40,000          -           -             -     40,000
Income tax benefit of non-
 qualified option exercises              -         -      37,000          -           -             -     37,000
                              -------------  -------    ---------   ---------   --------     ---------  ----------
BALANCE, March 31, 1998       14,143,000    14,000    8,467,000   (106,000)         -     8,931,000  17,306,000

Net Income                             -         -            -          -          -     5,418,000   5,418,000
Issuance of stock for the
 exercise of stock options       109,000         -       36,000          -          -             -      36,000
Issuance of below-market stock
 options                               -         -       90,000    (90,000)         -             -           -
Amortization of deferred
 compensation                          -         -            -    120,000          -             -     120,000
Income tax benefit of
 disqualifying dispositions            -         -       83,000          -          -             -      83,000
Income tax benefit of non-
 qualified option exercises            -         -       64,000          -          -             -      64,000
                              ----------   -------   ----------   --------  ---------   ----------- -----------
BALANCE, March 31, 1999       14,252,000   $14,000   $8,740,000   ($76,000) $       -   $14,349,000 $23,027,000
                              ==========   =======   ==========   ========= =========   =========== ===========
See Notes To Financial Statements.
</TABLE>
<PAGE> 27





                                      SYNTHETECH, INC.

                                   STATEMENT OF CASH FLOWS
                                   -----------------------
<TABLE>
<CAPTION>
<S>                                          <C>        <C>       <C>
For The Year Ended March 31,                    1999       1998       1997
- --------------------------------------          ----       ----       ----
 CASH FLOWS FROM OPERATING ACTIVITIES:
Net income                                    $5,418,000 $1,221,000 $4,112,000
Adjustments to reconcile net income to
  net cash provided by operating
  activities:
    Depreciation, amortization and
     other                                     1,351,000  1,014,000    268,000
    Amortization of deferred compensation        120,000    108,000    105,000
    Accrued interest on securities
     available for sale                                -          -      9,000
    Realized gain on securities
     available for sale                                -    (25,000)   (10,000)
    Provision for deferred income taxes          224,000    127,000     61,000
     (Increase) decrease in assets:
      Accounts receivable, net                (1,944,000)  (775,000)   660,000
      Inventories                               (175,000)(1,297,000)    37,000
      Prepaid expenses                           (88,000)   (32,000)   (93,000)
      Income tax receivable                            -    798,000   (646,000)
      Other assets                                19,000    (20,000)    (1,000)
    Increase (decrease) in liabilities:
      Accounts payable and accrued
       liabilities                             1,074,000    201,000    470,000
      Deferred revenue                          (203,000)   203,000    (54,000)
                                               ---------   --------   --------
        Net cash provided by operating
         activities                            5,796,000  1,523,000  4,918,000
                                               ---------  ---------  ---------
 CASH FLOWS FROM INVESTING ACTIVITIES:
   Property, plant and equipment purchases    (3,472,000)(4,089,000)(5,079,000)
   Proceeds from sale of securities
    available for sale and redemption
    of securities available for sale                   -    635,000    380,000
   Employee notes receivable                           -     30,000     50,000
                                               ---------  ---------  ---------
    Net cash used by investing activities     (3,472,000)(3,424,000)(4,649,000)
                                               ---------  ---------  ---------
 CASH FLOWS FROM FINANCING ACTIVITIES:
   Principal payments under long-term
    debt obligations                             (13,000)   (13,000)    (1,000)
   Proceeds from stock option exercises
    and disqualifying dispositions               183,000    150,000    979,000
   Proceeds from stock warrant exercises,
    including tax benefit                              -          -    444,000
                                              ---------- ----------  ---------
    Net cash provided by financing activities    170,000    137,000  1,422,000
                                              ---------- ----------  ---------
 NET INCREASE (DECREASE) IN CASH AND
  CASH EQUIVALENTS                             2,494,000 (1,764,000) 1,691,000
 CASH AND CASH EQUIVALENTS AT BEGINNING
  OF YEAR                                      4,976,000  6,740,000  5,049,000
                                              ---------- ----------  ---------
 CASH AND CASH EQUIVALENTS AT END OF YEAR     $7,470,000 $4,976,000 $6,740,000
                                              ========== ========== ==========
 NON-CASH INVESTING AND FINANCING ACTIVITIES:
   Unrealized loss on securities available
    for sale                                           -          -    $14,000
   Issuance of stock options at below fair
    value                                        $90,000    $21,000   $284,000
   Issuance of note payable for capital
    improvement                                        -          -   $194,000
   Mature shares exchanged for the exercise
    of stock options                            $401,000   $480,000   $112,000

See Notes to Financial Statements.
</TABLE>

<PAGE> 28



                        SYNTHETECH, INC.
                  NOTES TO FINANCIAL STATEMENTS

NOTE A.   GENERAL AND BUSINESS

          Synthetech, Inc., an Oregon corporation, specializes in
          developing  and   producing  Peptide  Building   Blocks
          (PBBs),  which are chemically modified forms of natural
          amino  acids  and  synthetic  non-natural  amino  acids
          (Specialty Amino Acids)  using a combination of organic
          chemistry  and biocatalysis.   The Company's  PBBs  are
          used  by pharmaceutical companies to make a wide  range
          of  peptide-based drugs under development  and  on  the
          market    for   the   treatment   of   AIDS,    cancer,
          cardiovascular  and other diseases.   The  Company  has
          established a worldwide reputation in a unique  product
          and  technology  area  as a leading  supplier  for  all
          phases  of  the  drug development cycle from  discovery
          through market launch.

NOTE B.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

          Use   of   Estimates:   The  preparation  of  financial
          statements   in  conformity  with  generally   accepted
          accounting  principles  requires  management  to   make
          estimates  and  assumptions that  affect  the  reported
          amounts  of  assets and liabilities and  disclosure  of
          contingent  assets and liabilities at the date  of  the
          financial  statements  and  the  reported  amounts   of
          revenues  and  expenses  during the  reporting  period.
          Actual results could differ from those estimates.

          Cash  and  Cash Equivalents:  Cash and cash equivalents
          include demand cash and all investments purchased  with
          an original maturity of three months or less.

          Securities Available for Sale:  In February  1998,  the
          Company  sold the last of its securities available  for
          sale.   Any  unrealized  gains  or  losses  have   been
          reflected  as  a  separate component  of  shareholders'
          equity   in  accordance  with  Statement  of  Financial
          Accounting Standards ("SFAS")  No. 115.

          Property,  Plant  and Equipment:  Property,  plant  and
          equipment  are  recorded  at  cost.   Depreciation  and
          amortization  are provided on the straight-line  method
          over  seven  to  forty  years for  buildings  and  land
          improvements,  and  five to seven years  on  all  other
          property.  When property is sold or retired,  the  cost
          and  accumulated  depreciation  are  removed  from  the
          accounts and the resulting gain or loss is included  in
          income.

          Revenue  Recognition:  Sales of products are recognized
          when  products are shipped and title and risk  of  loss
          have been passed to the customer.  The Company has  not
          experienced  any significant history of  sales  returns
          and  thus,  no  reserve  for  sales  returns  has  been
          provided.

<PAGE> 29

NOTE B.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

          Research   and   Development   Costs:    Research   and
          development costs are expensed as incurred.

          Other  Assets:  Other assets primarily represent patent
          costs, which are amortized over the useful life of  the
          patent.

          Earnings Per Share:  Basic earnings per share (EPS) are
          computed by dividing net income by the weighted average
          number of shares of common stock outstanding during the
          period.   Diluted  earnings per share are  computed  by
          dividing  net income by the weighted average number  of
          shares  of  common  stock and common stock  equivalents
          outstanding  during  the period, calculated  using  the
          treasury stock method as defined in SFAS No. 128.   The
          following  is  a reconciliation of the shares  used  to
          calculate basic earnings per share and diluted earnings
          per share:
          <TABLE>
          <CAPTION>
          <S>                            <C>         <C>         <C>
                                             1999        1998       1997
                                             ----        ----       ----
          Weighted average shares
           outstanding for basic EPS       14,200,399  13,921,164  13,659,927

          Dilutive effect of common stock
           options issuable under treasury
           stock method                        57,708     149,809     457,114
                                           ----------  ----------  ----------
          Weighted average common and
           common equivalent shares
           outstanding for diluted EPS     14,258,107  14,070,973  14,117,041
                                           ==========  ==========  ==========
          </TABLE>

          The  following  common stock equivalents were  excluded
          from  the earnings per share computation because  their
          effect would have been anti-dilutive:
          <TABLE>
          <CAPTION>
          <S>                                <C>         <C>       <C>
                                               1999        1998      1997
                                               ----        ----      ----
          Common stock options
           outstanding                        523,800     482,300           -
</TABLE>

<PAGE> 30

NOTE B.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES(CONTINUED)

          Supplemental cash flow disclosures are as follows:

            Cash Paid During The Year For:
<TABLE>
<CAPTION>
<S>                             <C>         <C>        <C>

                                    1999        1998       1997
                                    ----        ----       ----
          Income Taxes           $2,702,000  $  419,000  $2,232,000
          Interest               $   17,000  $   17,000  $    1,000

</TABLE>

NOTE B.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

          New Accounting Pronouncements:

          Comprehensive  Income:  In 1998,  the  Company  adopted
          SFAS  No.  130, "Reporting Comprehensive Income"  which
          requires  companies to report a measure of all  changes
          in  equity  except those resulting from  investment  by
          owners  and  distribution to  owners,  in  a  financial
          statement  for the period in which they are recognized.
          The  source  of comprehensive income for  the  Company,
          other   than   net  income,  is  losses  on  marketable
          securities available for sale.  The Company has elected
          to  disclose comprehensive income in the Statements  of
          Shareholders'  Equity and Comprehensive Income.   Prior
          years have been restated to conform to the requirements
          of SFAS No. 130.

          Segment  Reporting:  The Company adopted SFAS No.  131,
          "Disclosures  about  Segments  of  an  Enterprise   and
          Related Information" for the year ended March 31, 1999.
          Based  upon definitions contained within SFAS No.  131,
          the  Company  has  determined that it operates  in  one
          segment.

          Derivative  Reporting:   In June  1998,  the  Financial
          Accounting   Standards  Board  issued  SFAS   No.   133
          "Accounting  for  Derivative  Instruments  and  Hedging
          Activities."   SFAS No. 133 establishes accounting  and
          reporting  standards  for  all derivative  instruments.
          SFAS  No.  133 is effective for fiscal years  beginning
          after  June  15, 1999.  The Company does not  have  any
          derivative  instruments and, accordingly, the  adoption
          of  SFAS  No. 133 will have no impact on the  Company's
          financial position or results of operations.


          Reclassifications:  Certain amounts in the  prior  year
          financial statements have been reclassified to  conform
          to the current presentation.











<PAGE> 31

NOTE C.   INVENTORIES

          Inventories are stated at the lower of cost or  market,
          determined  on  the first-in, first-out  (FIFO)  basis.
          Cost  utilized  for inventory purposes  include  labor,
          material, and manufacturing overhead.

          The major components of inventories are as follows:
<TABLE>
<CAPTION>
<S>                               <C>            <C>
                                            March 31,
                                            ---------
                                       1999           1998
                                       ----           ----
          Finished products        $ 1,206,000    $ 1,009,000
          Work-in-process              824,000      1,033,000
          Raw materials              1,329,000      1,142,000
                                   -----------    -----------
                                   $ 3,359,000    $ 3,184,000
                                   ===========    ===========
</TABLE>

NOTE D.   PROPERTY, PLANT AND EQUIPMENT

          Property, plant and equipment consist of the following:
<TABLE>
<CAPTION>
          <S>                       <C>           <C>

                                              March 31,
                                              ---------
                                         1999           1998
                                         ----           ----
          Land                      $     91,000   $     91,000
          Buildings                    4,446,000      4,340,000
          Machinery and equipment      7,293,000      6,277,000
          Laboratory equipment           400,000        338,000
          Furniture and fixtures         283,000        176,000
          Vehicles                       132,000         84,000
          Construction in progress     2,600,000        468,000
                                      ----------     ----------
                                      15,245,000     11,774,000
          Less:
          Accumulated depreciation     3,684,000      2,335,000
                                    ------------   ------------
                                    $ 11,561,000   $  9,439,000
                                    ============   ============
</TABLE>

<PAGE> 32

 NOTE E.  INCOME TAXES

          The  Company accounts for income taxes under the  asset
          and  liability  method as defined by the provisions  of
          Statement  of  Financial Accounting Standards  No.  109
          (SFAS  109),  Accounting for Income Taxes.  Under  this
          method,  deferred income taxes are recognized  for  the
          future   tax  consequences  attributable  to  temporary
          differences  between the financial  statement  carrying
          amounts  and  tax  balances  of  existing  assets   and
          liabilities.   Deferred tax assets and liabilities  are
          measured  using the enacted rates expected to apply  to
          taxable  income  in  the  years which  those  temporary
          differences are expected to be recovered or settled.

          The  provision for income taxes in fiscal 1999,  fiscal
          1998  and fiscal 1997 included a deferred tax provision
          of $224,000, $127,000 and $61,000, respectively.

          Total deferred tax assets and liabilities at March  31,
          1999  were $133,000 and $496,000, respectively.   Total
          deferred tax assets and liabilities at March 31,  1998,
          were  $70,000  and $209,000, respectively. Individually
          significant  differences included book/tax depreciation
          differences  which  were recorded  as  a  deferred  tax
          liability  of $496,000 and $209,000 at March  31,  1999
          and March 31, 1998, respectively.

          The  reconciliation between the effective tax rate  and
          the statutory federal income tax rate is as follows:
<TABLE>
<CAPTION>
<S>                                    <C>      <C>      <C>

                                        1999      1998     1997
                                        ----      ----     ----
          Statutory federal tax rate    34.0%     34.0%    34.0%
          State taxes                    4.4%      2.5%     4.4%
          Foreign sales corporation
           benefit                      (0.6)%    (1.5)%   (1.5)%
          Other                         (1.3)%     1.5%     1.1%
                                        -----     -----    -----
          Effective tax rate            36.5%     36.5%    38.0%
                                        =====     =====    =====
</TABLE>


NOTE  F.  LINE OF CREDIT

          The  Company has a line of credit available with a bank
          in the amount of $1 million with an applicable interest
          rate  equal to the bank's prime lending rate which  was
          7.75%  at  March  31,  1999.   There  were  no  amounts
          outstanding  under this loan at the end of  the  fiscal
          year.   This line of credit is renewable on August  26,
          1999.

<PAGE> 33

NOTE G.   NOTE PAYABLE

          In  1997, the Company entered into a note payable  with
          the  City  of  Albany for payment of wastewater  system
          development  charges  assessed in connection  with  the
          Company's plant expansion.  The note bears interest  of
          9.0%  and  is  due  in monthly installments  of  $2,459
          through  February  2007.  The note is  secured  by  the
          Company's property, plant and equipment.

NOTE H.   SHAREHOLDERS' EQUITY

          On  September 17 and 19, 1996, the Emanuel and  Company
          warrant  authorized  by  the  Board  of  Directors   on
          February 5, 1992 was exercised.  The exercise price  of
          the  5-year  warrant for 100,000 shares was  $2.22  per
          share.   On  December 19, 1996, Mr.  Page  Golsan,  III
          exercised  the  warrant  authorized  by  the  Board  of
          Directors  on January 7, 1992.  The exercise  price  of
          the  5-year  warrant for 25,000 shares  was  $1.81  per
          share.  The net proceeds of these warrant exercises was
          $228,000.   As of March 31, 1997, there were  no  stock
          warrants outstanding.

          In  July 1998, the Company adopted a Shareholder Rights
          Plan  (the "Rights Plan").  Under the Rights Plan,  the
          Company  declared  a  dividend  of  one  common   share
          purchase  right (a "Right") for each outstanding  share
          of common stock outstanding at the close of business on
          August  4,  1998.   The  Rights are  attached  to,  and
          automatically trade with, the outstanding shares of the
          Company's common stock.  Under certain conditions, each
          right may be  exercised to purchase one share of common
          stock at a purchase price of $30 per share, subject  to
          adjustment.   In  the  event that  a  person  or  group
          acquires  15%  or more of the Company's  common  stock,
          each  Right  will  entitle all  other  shareholders  to
          purchase from the Company common stock having a  market
          value  equal  to two times the exercise  price  of  the
          Right.   In addition, if the Company is acquired  in  a
          merger or other business combination transaction or 50%
          or more of its consolidated assets or earning power are
          sold,  proper  provision will  be  made  so  that  each
          shareholder with unexercised Rights will be entitled to
          purchase  common stock of the acquirer with a value  of
          twice the exercise price of the Rights.  The Company is
          entitled  to redeem the Rights at $.0001 per  Right  at
          any  time prior to the earlier of the expiration of the
          Rights in July 2008 or the time that a person or  group
          has  acquired a 15% position.  The Rights do  not  have
          voting or distribution rights.

          Under  the Amended and Restated 1990 Stock Option  Plan
          1,600,000 shares were authorized for issuance.  A total
          of  1,491,160 options were granted under this plan.   A
          total  of  1,398,837  options have been  exercised  and
          55,110 options have been cancelled as of March 31, 1999
          under  the  plan  since  its  inception.   The  options
          granted  under  this plan vest over a two  year  period
          from  the  beginning of the fiscal year  in  which  the
          options are granted and a maximum term of 5 years.

<PAGE> 34

NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)

          The 1995 Incentive Compensation Plan authorized 902,000
          shares of the Company's stock to be issued.  This  plan
          is the successor to the Amended and Restated 1990 Stock
          Option Plan.  No further grants will be made under  the
          original  plan.  A total of 846,000 options  have  been
          granted  under  this plan.  A total of  16,000  options
          have  been  exercised  and 207,700  options  have  been
          cancelled as of March 31, 1999 under the plan since its
          inception.   The  options  granted  under   this   plan
          generally vest 50% after 1 year and 100% after 2  years
          from  the  beginning of the fiscal year  in  which  the
          options are granted.  However, to a lesser extent, some
          options vest from 50% after one year of employment  and
          100% after 2 years of employment, and some options vest
          in  less  than  a  year and others up  to  five  years.
          Options granted under this plan have a maximum term  of
          10  years.   The 1995 Incentive Compensation  Plan  was
          amended  in  November 1996 to permit granting  of  non-
          qualified options to directors who are not employees of
          the Company.

          During  1995, the Financial Accounting Standards  Board
          issued SFAS 123 which defines a fair value based method
          of  accounting for an employee stock option or  similar
          equity instrument and encourages all entities to  adopt
          that  method  of  accounting for all of their  employee
          stock  compensation plans.  However, it also allows  an
          entity  to  continue to measure compensation  cost  for
          those  plans using the method of accounting  prescribed
          in  APB  25.   Entities electing  to  remain  with  the
          accounting in APB 25 must make pro forma disclosures of
          net income and, if presented, earnings per share, as if
          the  fair  value based method of accounting defined  in
          the Statement had been applied.

          The  Company has elected to account for its stock-based
          compensation plan under APB 25.  However,  the  Company
          has  computed,  for pro forma disclosure purposes,  the
          value of all options granted during fiscal 1999, fiscal
          1998  and  fiscal 1997 using the Black-Scholes  option-
          pricing  model  as prescribed by SFAS  123,  using  the
          following  weighted average assumptions for  grants  in
          fiscal 1999, fiscal 1998 and fiscal 1997:
<TABLE>
<CAPTION>
<S>                                <C>          <C>          <C>
          Fiscal Year                 1999         1998         1997
          -----------                 ----         ----         ----
          Risk-free interest rate     5.50%        6.49%        6.49%
          Expected dividend yield        0%           0%           0%
          Expected life             3.81 years   3.60 years   3.89 years
          Expected volatility           55%          57%       49-50%

</TABLE>

          The  total value of options granted during fiscal 1999,
          fiscal 1998 and fiscal 1997 would be amortized on a pro
          forma  basis  over the vesting period of  the  options.
          Options generally vest equally over two years.  If  the
          Company  had accounted for these options in  accordance
          with SFAS 123, the Company's net income and

<PAGE> 35

NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)

          earnings per share would have decreased as reflected in
          the following pro forma amounts:
<TABLE>
<CAPTION>
<S>                                 <C>         <C>          <C>
                                             Year ended March 31,
                                             --------------------
                                        1999         1998         1997
                                        ----         ----         ----
          Net income:
             As reported            $ 5,418,000  $ 1,221,000  $ 4,112,000
             Pro forma                4,761,000      322,000    3,461,000
          Basic earnings per Share:
             As reported                  $0.38        $0.09        $0.30
             Pro forma                    $0.33        $0.02        $0.25
          Diluted earnings per share:
             As reported                  $0.38        $0.09        $0.29
             Pro Forma                    $0.33        $0.02        $0.25
</TABLE>

          Using the Black-Scholes methodology, the total value of
          options  granted  during fiscal 1999, fiscal  1998  and
          fiscal  1997  was  $743,000, $873,000  and  $1,375,000,
          respectively, which would be amortized on a  pro  forma
          basis  over  the  vesting period of the  options.   The
          weighted  average fair value of options granted  during
          fiscal  1999,  fiscal 1998 and fiscal 1997  was  $3.05,
          $3.45 and $4.17, respectively.

          Activity  under  the  Amended and Restated  1990  Stock
          Option Plan and 1995 Incentive Compensation Plans  over
          the last three fiscal years is summarized as follows:
<TABLE>
<CAPTION>
<S>                        <C>     <C>     <C>      <C>    <C>     <C>
                                           Year ended March 31,
                                 1999              1998             1997
                            ---------------  ----------------  --------------
                                     Wtd.            Wtd.             Wtd.
                                     Avg.            Avg.             Avg.
                                      Ex.             Ex.              Ex.
                             Shares  Price   Shares  Price   Shares   Price
                             ------  -----   ------  -----   ------   -----
Options outstanding at
 beginning of year          749,400  $5.85   913,810  $4.06  871,960  $2.02
Granted                     244,000  $5.64   253,000  $7.05  330,000  $7.40
Exercised                  (173,887) $2.52  (373,710) $2.04 (275,950) $1.58
Cancelled                  (160,000) $7.45   (43,700) $8.02  (12,200) $4.70
                           --------- -----   -------- -----  -------- -----
Options outstanding at
 end of year                659,513  $6.26   749,400  $5.85  913,810  $4.06
                            =======  =====   =======  =====  =======  =====
Exercisable at end of year  346,113  $6.40   381,183  $4.48  484,010  $2.08



Weighted average fair value
 of options granted at market
 value                            -  $2.84         -  $3.41        -  $3.78
Weighted average fair value
 of options granted at below
 market value                     -  $5.45         -  $7.02        -  $5.86
</TABLE>

<PAGE> 36


NOTE H.   SHAREHOLDERS' EQUITY (CONTINUED)


          The  following  table  sets forth  the  exercise  price
          range, number of shares outstanding at March 31,  1999,
          weighted  average remaining contractual life,  weighted
          average  exercise  price, number of exercisable  shares
          and  weighted  average  exercise price  of  exercisable
          options by groups of similar price and grant date:
<TABLE>
<CAPTION>
<S>   <C>    <C>  <C>  <C>  <C>  <C>
                     Options Outstanding          Options Exercisable
             ----------------------------------  ----------------------
                           Wtd. Avg.
                           Remaining
Exercise     Outstanding  Contractual  Wtd. Avg.   Wtd. Avg.
Price           Shares       Life      Exercise   Exercisable  Exercise
Range        at 3/31/99    (Years)      Price      Options      Price
- -----------   ---------     ------     ------      -------      ------
$0.30-$1.08     23,500       9.30       $0.83       4,500       $0.51
$1.72-$1.81     50,000       8.58       $1.81      50,000       $1.81
$2.22-$4.38     62,213       4.47       $3.46      37,213       $2.84
$6.25-$8.50    523,800       8.87       $7.27     254,400       $7.92
</TABLE>



NOTE I.            401(k) PROFIT SHARING PLAN

          The Company established a 401(k) Profit Sharing Plan on
          April  1,  1992.   This  plan is  offered  to  eligible
          employees,  who may elect to contribute up  to  15%  of
          compensation   and   includes   a   Company    matching
          contribution.   The Company's matching contribution  is
          $.50,  $.75 and $1.00 for each $1.00 contributed up  to
          10%  of compensation corresponding to length of service
          with  the  Company.   The Company contribution  becomes
          fully  vested  for  each  employee  after  5  years  of
          employment.   The  Company  matching  contribution  for
          fiscal  years 1999, 1998, and 1997 was $77,000, $46,000
          and $77,000, respectively.

<PAGE> 37


NOTE J.   SEGMENT INFORMATION

          Long-lived assets, other than in the United States, are
          not material.

          Significant  Customers:  During fiscal year  1999,  two
          customers accounted for 44% and 20% of revenues. During
          fiscal  year 1998, two customers accounted for 23%  and
          11%   of  revenues.   During  fiscal  year  1997,   two
          customers accounted for 30% and 29% of revenues.

          The following table reflects sales and percent of total
          sales by geographic area:
<TABLE>
<CAPTION>
<S><C>            <C>         <C>    <C>           <C>     <C>         <C>

                         1999                1998                1997
                   ------------------  ------------------  ------------------
    United States  $ 16,680,000 72.1%  $  5,472,000 65.7%  $  8,655,000 67.6%
           Europe     5,688,000 24.6%     2,606,000 31.3%     1,262,000  9.9%
           Japan        198,000  0.8%       205,000  2.5%     2,880,000 22.5%
           Other        567,000  2.5%        38,000   .5%             -    -
                   ------------ -----  ------------ ------ ------------ -----
           Total   $ 23,133,000  100%  $  8,321,000  100%  $ 12,797,000  100%
                   ============        ============        ============
</TABLE>

<PAGE> 38

     ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS
             ON ACCOUNTING AND FINANCIAL DISCLOSURE

Not applicable.

                            PART III

        ITEM 10.  DIRECTORS AND EXECUTIVE OFFICERS OF THE
                           REGISTRANT

The following table sets forth certain information concerning the
executive officers, key employees and directors of the Company:
<TABLE>
<CAPTION>
<S>  <C>                            <C>    <C>

         Name                         Age           Position
         ----                         ---           --------
     M. ("Sreeni") Sreenivasan         50   President, Chief Executive
                                             Officer and Director
     Charles B. Williams               52   Vice President of Finance
                                             and Administration, Chief
                                             Financial Officer,
                                             Secretary, Treasurer, and
                                             Director
     Timothy D. Fitzpatrick           34    Director of R&D and Pilot
                                             Plant Operations
     Joel D. Melka                    44    Director of Manufacturing
     Mitchell R. McVay                48    Director of Engineering
     Paul C. Ahrens                   47    Chairman of the Board
     Howard L. Farkas                 75    Director
     Edward M. Giles                  63    Director
     Page E. Golsan, III              61    Director
     Donald E. Kuhla, Ph.D.           56    Director

</TABLE>

The  following  is a brief account of the business experience  of
each executive officer, key employee and director of the Company.

M. "Sreeni" Sreenivasan.  Mr. Sreenivasan has served as President
and  Chief  Executive Officer since 1995 and as  Chief  Operating
Officer from 1990 through 1995.  Mr. Sreenivasan has also  served
as a Director since 1995. From 1988 to 1990 he was Executive Vice
President  and  General Manager and from  1987  to  1988  he  was
director  of Manufacturing.  Previously, he worked for  Ruetgers-
Nease   Chemical  Co.  (bulk  pharmaceuticals  and   other   fine
chemicals)  for  13 years in various technical and  manufacturing
management  capacities, including 7 years  as  Plant  Manager  of
their  Augusta, Georgia plant. Mr. Sreenivasan received his  M.S.
in  Chemical Engineering from Bucknell University and his  M.B.A.
from Penn State University.

Charles  B. Williams.  Mr. Williams has served as Vice  President
of Finance and Administration and Treasurer since 1990.  In 1995,
he  also  became  Chief Financial Officer  and   Secretary.   Mr.
Williams  has also served as a director since 1997.  Mr. Williams
is responsible for accounting,

<PAGE> 39

administration, finance, personnel and information systems.  From
1988  to  1990  Mr.  Williams served as  the  Controller.   Prior
thereto, he was Controller for White's Electronics, Inc. of Sweet
Home,  Oregon  for  5 years. From 1976 to 1983  he  held  several
accounting  and financial positions with Teledyne  Wah  Chang,  a
metals producer in Albany, Oregon.  Mr. Williams earned his  B.S.
in Economics and M.B.A. from Oregon State University.

Timothy D. Fitzpatrick. Mr. Fitzpatrick has served as Director of
R&D  and  Pilot Plant Operations since October  1, 1998.   From
1994  to  1998 he was the R&D  Laboratory  Manager. Previously,
he worked for Cortech, Inc. from 1993  to  1994  and Somatogen, Inc.
from 1992 to 1993 (both start-up  biotechnology companies) as a
research scientist in new drug discovery.   Prior to  1992,  he
was a research chemist in LHRH Drug  Discovery  at Abbott  Laboratories
of North Chicago, Illinois  (pharmaceutical research  and manufacturing).
Mr. Fitzpatrick holds his  M.S.  in Organic  Chemistry from University
of Wisconsin-Madison  and  his B.S. in Chemistry from Montana Tech.

Mitchell R. McVay. Mr. McVay has been Director of Engineering
since April 1, 1998. From 1996 to 1998 he served  as the  Plant  Engineer.
Previously Mr. McVay worked  for  Salsbury Chemicals Inc.   ,  a  division
of  Cambrex   Inc.   (chemical manufacturing)  from  1983  to  1996  in
various  technical  and management   capacities,  his  last  position being
the Manager   of Engineering  and  Maintenance. Mr. McVay  received  his  B.S.
in Chemical Engineering from Texas A & M University.

Joel  D.  Melka.  Mr.  Melka joined the Company  as  Director  of
Manufacturing in February 1999. From 1988 to 1999  he  worked  at
ChemDesign  Inc.  (custom  chemical  manufacturing)  in   various
capacities,  his last position being Director of  Manufacturing.
From  1984 to 1988, he worked for Polaroid Corporation in various
manufacturing positions. Prior to 1984, he spent 5  years  as  an
officer  in  the U.S. Navy nuclear submarine service.  Mr.  Melka
received  his  M.S. in Chemistry from the University  of  British
Columbia  and  his B.S. in Chemistry from Michigan  Technological
University .

Paul  C.  Ahrens.  Mr. Ahrens has been a director of the  Company
since  its inception in 1981 and became Chairman of the Board  in
1995.   Since  1996  he  has been the founder  and  President  of
Groovie Moovies, Ltd., a film production company.  Mr. Ahrens,  a
founder  of the Company, served as President and Chief  Executive
Officer  of Synthetech from 1989 through March 1995.   From  1981
through  1989 he was the Vice President of Technology.   He  also
served as Secretary of the Company from 1981 through 1995.   From
1979  to  1980 Mr. Ahrens served as Vice President of Engineering
of   Colorado  Organic  Chemical  Company,  an  organic  chemical
manufacturing company located in Commerce City, Colorado.   Prior
thereto,  Mr.  Ahrens spent five years with Allied  Chemical  and
CIBA-Geigy   in  various  engineering  and  research  capacities.
Mr.  Ahrens  holds B.S. and M.S. degrees in Chemical  Engineering
from M.I.T.

Howard  L.  Farkas.  Mr. Farkas has served as a director  of  the
Company  since  1985.  Since 1981 he has been  the  President  of
Farkas  Group,  Inc.,  and since 1992 he has  been  President  of
Windsor  Gardens  Realty,  Inc., both of  which  are  engaged  in
general  real estate brokerage and management activities.    From
1984  to  1996 he was also the managing director in Manistee  Gas
Limited  Liability  Company, which is in the gas  production  and
processing  business.  Mr.  Farkas  serves  as  Secretary  and  a
director  of  Acquisition  Industries,  Inc.,  a  publicly  owned
acquisition

<PAGE> 40

and  merger  company.  Mr. Farkas serves as the Chairman  of  the
Board  of  Logic  Devices, Inc., a Sunnyvale, California  company
specializing  in  CMOS digital signal process  semiconductor  and
SRAM  chips.   Since May 1988 Mr. Farkas has  also  been  a  vice
president  of  G.A.S.  Corp., which is a general  partner  of  an
Oklahoma  limited  partnership, Gas Acquisition  Services,  which
filed  for  bankruptcy  under Chapter  11.   In  September  1992,
Mr.  Farkas filed for personal protection under Chapter 7 of  the
federal  bankruptcy  laws and the court subsequently  entered  an
order  discharging his debts.  Though not presently in public  or
private practice, he has been a certified public accountant since
1951.  Mr.  Farkas received a B.S. (B.A.) from the University  of
Denver.

Edward M. Giles.  Mr. Giles has served as a director since  1997.
Since 1989 he has served as Chairman of The Vertical Group, Inc.,
a  venture capital investment firm.  He was also President of The
Vertical  Group  from  1989 to 1998.  Mr.  Giles  was  previously
President  of  F. Eberstadt & Co., Inc., a securities  firm,  and
Vice  Chairman  of  Peter B. Cannell & Co., Inc.,  an  investment
management  firm.   He  is  currently  a  director  of  McWhorter
Technologies, Inc. and Ventana Medical Systems, Inc.   Mr.  Giles
received  a  B.S.  in  Chemical Engineering  from  Princeton
University  and  an  M.S.  in  Industrial  Management  from   the
Massachusetts Institute of Technology.

Page E. Golsan, III.  Mr. Golsan has served as a director of  the
Company  since 1991.  Since 1986 he has been a principal of  P.E.
Golsan  &  Co.  (formerly Golsan Management Company),  a  private
capital  management firm.  From 1990 to 1992, Mr.  Golsan  was  a
senior advisor with Bane Barham & Holloway, registered investment
advisors  under the Investment Advisor Act of 1940.   Since  1990
Mr.  Golsan  has  been President and Chief Executive  Officer  of
Bridgetown  Capital, Inc., an investment company.  From  1987  to
1989  he  was the Executive Vice President of Calumet Industries,
Inc.,  Chicago,  Illinois (manufacturer and  marketer  of  petro-
chemicals  and other fine chemicals).  Prior to 1987 he  was  the
President  and  Chief  Operating  Officer  of  the  K&W  Products
Division   (specialty   chemical  manufacturing)   of   Berkshire
Hathaway, Inc. Mr. Golsan holds an M.A. in Finance from Claremont
Graduate  School of Business and a Doctorate in  Pharmacy  and  a
B.A.  in  Chemistry  and  Zoology, both from  the  University  of
Southern California.

Donald E. Kuhla, Ph.D.  Dr. Kuhla has served as a director  since
1997.   Since  1998  he  was  President and  Chief  Operating
Officer  of  Albany  Molecular Research,  Inc. (contract  research
organization).  From 1994 to 1998, he has been Vice President and
Chief  Technical  Officer  of Plexus Ventures,  Inc.,  a  biotech
consulting  and  investment firm.   From 1990 to 1994  Dr.  Kuhla
held senior management positions with two venture capital backed,
biotechnology start-up companies.  Previously, he was in research
and  development and operations management positions with  Pfizer
Inc.  and  Rorer  Group, Inc., his last position at  Rorer  being
Senior Vice President of Operations.  Dr. Kuhla is a director  of
NPS  Pharmaceuticals, Inc. (a biotechnology  drug  discovery  and
development  company).  Dr. Kuhla received a  B.A.  in  Chemistry
from  New  York University and a Ph.D. in Organic Chemistry  from
Ohio State University.

<PAGE> 41


Schedule 16(a) Beneficial Ownership Reporting Compliance
- --------------------------------------------------------
Section 16(a) of the Securities Exchange Act of 1934, as amended,
requires  the Company's officers and directors, and  persons  who
own  more than 10% of a registered class of the Company's  equity
securities, to file reports of ownership on Form 3 and changes in
ownership  on  Form 4 or Form 5 with the Securities and  Exchange
Commission   ("SEC").    Such   officers,   directors   and   10%
shareholders  are  also  required by SEC  rules  to  furnish  the
Company with copies of all Section 16(a) forms they file.

Based  solely on its review of the copies of such forms  received
by it, or written representations from certain reporting persons,
the Company believes that, during the fiscal year ended March 31,
1999,  all  Section 16(a) filing requirements applicable  to  its
officers, directors and 10% shareholders were complied with, except
that Messrs. Fitzpatrick, McVay and Melka each failed to file a Form 3
and Form 5.



                ITEM 11.  EXECUTIVE COMPENSATION

REPORT OF THE COMPENSATION COMMITTEE

The  Compensation  Committee sets, reviews  and  administers  the
executive compensation program of the Company and is comprised of
the  individuals  noted  below, each  of  whom  are  non-employee
directors of the Company.  The role of the Compensation Committee
is  to establish and approve salaries and other compensation paid
to  the  executive officers of the Company and to administer  the
Company's  stock option plan, in which capacity the  Compensation
Committee  reviews  and  approves  stock  option  grants  to  all
employees.

Compensation Philosophy.  Synthetech's compensation philosophy is
that  cash  compensation should be directly linked to the  short-
term  performance of the Company and that longer-term incentives,
such  as  stock options, should be aligned with the objective  of
enhancing shareholder value over the long term. The use of  stock
options clearly links the interests of the officers and employees
of  the  Company  to  the  interests  of  the  shareholders.   In
addition,  the  Compensation Committee believes  that  the  total
compensation package must be competitive with other companies  in
the  industry to ensure that the Company can continue to attract,
retain  and motivate key employees who are critical to the  long-
term success of the Company.

Components  of Executive Compensation.  The principal  components
of  executive  compensation are base salary,  bonuses  and  stock
options.

Base  salary is set based on competitive factors and the historic
salary structure for various levels of responsibility within  the
Company.  In addition, the Company relies on bonuses in order  to
emphasize the importance of performance.

The  equity  component  of executive compensation  is  the  stock
option  program.  Stock  options are generally  granted  when  an
executive  joins the Company and, typically, on an  annual  basis
thereafter.   The options granted to the executives vest  over  a
period of two years.  The purpose of

<PAGE> 42

the  annual option grants is to ensure that the executive  always
has  options that vest in increments over the following  two-year
period.   This provides a method of retention and motivation  for
the senior level executives of the Company and also aligns senior
management's objectives with long-term stock price appreciation.

Other elements of executive compensation are participation  in  a
Company-wide  life  insurance,  long-term  disability  insurance,
medical benefits and ability to defer compensation pursuant to  a
401(k)  plan.  Matching Company contributions to the 401(k)  plan
of up to 10% of eligible base pay were made in fiscal 1999.

As a result of the Company's excellent fiscal 1999 performance,
including record revenues and profits, the Compensation Committee
granted significant bonuses to Mr. Sreenivasan, the CEO, and Mr.
Williams, the CFO.   Recognizing Mr. Sreenivasan's long term
efforts on behalf of the Company, the Compensation Committee also
granted him a $45,000 one-time bonus payable over the next three years.
Mr. Sreenivasan received $7,500 of this bonus in fiscal 1999.
Consistent with its policy to create longer-term incentives, the
Compensation Committee granted stock options to the executive
officers, including a 24,000 share option to Mr. Sreenivasan.



                              Paul C. Ahrens
                              Edward M. Giles
                              Page E. Golsan III
                              COMPENSATION COMMITTEE OF THE BOARD
                              OF DIRECTORS

Compensation Committee Interlocks and Insider Participation.  The
members  of  the  Compensation  Committee  are  Paul  C.  Ahrens,
Edward  M. Giles and Page E. Golsan III.  Mr. Ahrens is  formerly
an officer of the Company.

<PAGE> 43

Summary of Cash and Certain Other Compensation
The following table provides certain summary information
concerning compensation paid by the Company to those persons who
were at March 31, 1999, the Company's Chief Executive Officer,
Chief Financial Officer and two other key employees of the
Company whose salary and bonus exceeded $100,000 during the last
fiscal year (the "Named Persons") for the fiscal years ended
March 31, 1999, 1998 and 1997:
<TABLE>
<CAPTION>
<S><C>             <C>       <C>       <C>       <C>         <C>

                              Summary Compensation Table
                              --------------------------
                                                  Long-Term     All Other
                         Annual Compensation      Compensation Compensation($)(2)
                     ---------------------------  ------------ ------------
Name and Principal                                   Stock
Position             Year(1)  Salary($)  Bonus($)   Options(#)
- ------------------  --------  ---------  -------- ------------- -----------

M.("Sreeni")
Sreenivasan          1999      165,000    71,500(3)    24,000      11,200
President & Chief    1998      150,000         -       25,000      12,500
Executive Officer    1997      150,000    95,000       50,000       7,125

Charles B. Williams  1999       99,000    36,000       19,000       9,900
Vice President of    1998       88,000         -       20,000       7,950
Finance and          1997       88,000    57,000       32,000       6,544
Administration &
Chief Financial
Officer

Mitchell  R. McVay   1999       85,500    24,000       19,000           -
Director of          1998       78,000         -       15,000         975
Engineering          1997       74,250    30,000            -           -

Timothy D.           1999       71,500    30,600       35,000       4,130
Fitzpatrick          1998       60,000     2,500        9,500       4,050
Director of R&D and  1997       57,500    21,000       11,000       3,488
Pilot Plant
Operations

</TABLE>
_______________________
(1)Fiscal year ended March 31.
(2)Represents Company contributions to the account of  the  Named
 Persons under the Company's 401(k) plan.
(3)Mr.  Sreenivasan was granted a special $45,000  bonus  payable
 over  three years.  The fiscal 1999 bonus set forth in the table
 includes the initial $7,500 payment of this bonus.  See  "Report
 of the Compensation Committee" above.

<PAGE> 44



Stock Option Grants in Last Fiscal Year
The following table provides information, with respect to the
Named Persons, concerning the grant of stock options during
fiscal year 1999.
<TABLE>
<CAPTION>
<S><C>         <C>     <C>        <C>       <C>         <C>        <C>

               Stock Options Grants in the Last Fiscal Year(1)
               -----------------------------------------------
                                                       Potential Realizable Value
                                                       at Assumed Annual Rates of
                                                       Stock Price Appreciation
                            Individual Grants         (Through Expiration Date)
                 ------------------------------------ ------------------------
                 Options
                 Granted             Exercise
                 (# of   % of Total  Price    Expiration   5% Per    10% Per
Name             Shares) Options(2) ($/Sh)(3)     Date      year(4)  Year(4)
- ----             ------- ----------  -------   --------    -------   -------
M. ("Sreeni")
Sreenivasan      24,000     9.8%      $6.25    May 2008     $82,800  $203,760

Charles B.
Williams         19,000     7.8%      $6.25    May 2008     $65,550  $161,310

Mitchell R.
McVay            19,000     7.8%      $6.25    May 2008     $65,550  $161,310

Timothy D.       10,000     4.1%       $6.25    May 2008    $34,500   $84,900
Fitzpatrick      25,000    10.2%       $4.38    Oct 2008    $60,370  $148,695

</TABLE>
_______________________
(1)The  Company  has  not granted any stock  appreciation  rights
 (SARs).
(2)Based on an aggregate of 244,000 options being granted to  all
 employees during the fiscal year ended March 31, 1999.
(3)These  options were granted under the Company's 1995 Incentive
 Compensation  Plan  in  May 1998 to  each  individual   for  the
 options  expiring  in  May 2008, and  in  October  1998  to  Mr.
 Fitzpatrick  for  the  option expiring in  October  2008.   Each
 option  has an exercise price equal to the fair market value  of
 the  Company's Common Stock as of the date of the  grant.  These
 grants  vest annually over a two-year period ending  April  2000
 for  each  individual for the options expiring in May  2008,
 and  the two-year period ending October 2000 for Mr. Fitzpatrick
 for the option expiring in October 2008.
(4)The  5% and 10% assumed rates of appreciation are mandated  by
 the  rules of the Securities and Exchange Commission and do  not
 represent the Company's estimate or projection of future  prices
 for its Common Stock.

Stock  Option  Exercises in Last Fiscal Year and Fiscal  Year-End
Stock Option Values
- -----------------------------------------------------------------
The following table provides information, with respect to the
Named Persons, concerning the options granted to them during the
last fiscal year and the options held by them at March 31, 1999.
<TABLE>
<CAPTION>
<S><C>      <C>     <C>          <C>         <C>        <C>         <C>

 Option Exercises in Last Fiscal Year and Fiscal Year End Stock Option Values
 ----------------------------------------------------------------------------
                                       Number of       Value of Unexercised In-
              Shares              Unexercised Options    the-Money Options at
             Acquired              at Fiscal Year End   Fiscal Year End($)(1)
                on     Value      ---------- ----------  ---------- ---------
             Exercise Realized      Exerci-   Unexerci-   Exerci-   Unexerci-
Name            (#)     ($)          sable       sable     sable      sable
- ----         -------- ---------   ----------  ----------  ---------  --------
M.("Sreeni")
Sreenivasan   47,887  $133,605       80,613     36,500     $27,894      $0

Charles B.
Williams           0        $0       42,000     29,000         $0       $0

Mitchell R.
McVay          2,500   $14,350        9,000     26,500     $5,805       $0

Timothy D.
Fitzpatrick        0       $0        15,750     39,750         $0       $0
</TABLE>

<PAGE> 45
_______________________
(1)Represents  the difference between the exercise price  of  the
 options  with exercise prices below $4.38 and the $4.38  closing
 price of the Company's Common Stock on March 31, 1999.


Comparison of Total Cumulative Shareholder Equity

The  following  graph sets forth the Company's  total  cumulative
shareholder return as compared to the Nasdaq Stock Market  (U.S.)
and S&P Specialty Chemicals Indexes for the period March 31, 1994
through  March  31, 1999.  The total shareholder  return  assumes
$100  invested at the beginning of the period in Common Stock  of
the  Company,  Nasdaq  Stock Market Index   (U.S.)  and  the  S&P
Specialty  Chemicals Index.  Historic stock price performance  is
not necessarily indicative of future stock price performance.


Edgar Representation of Data Points Used in Printed Graphic
<TABLE>
<CAPTION>
<S>       <C>       <C>            <C>            <C>


                                                    S&P
                                 Nasdaq Stock     Specialty
                                 Market Index     Chemicals
                   Synthetech       (U.S)           Index
                   ----------    ------------     ----------
           1994     $ 100.00       $ 100.00        $ 100.00
           1995        84.62         111.25          100.65
           1996       246.10         151.06          129.94
           1997       312.76         167.83          116.80
           1998       253.81         254.43          147.98
           1999       179.45         342.42          124.69

</TABLE>

          All data points are at March 31.

<PAGE> 46



Employment Agreements


In  July,  1997,  the Company entered into Employment  Agreements
with  Messrs.  Sreenivasan, Knutson and  Williams  (collectively,
"Executives"  and  individually, "Executive").   In  addition  to
providing for an annual base salary, the Agreements have  certain
noncompetition and nonsolicitation provisions.  Pursuant  to  the
Agreements, the Company will pay the Executives certain  payments
after  termination of employment for any reason other than death.
Specifically, the Company will pay an amount equal  to  the  base
salary  earned  by the Executive during the twelve  month  period
immediately preceding the date of termination plus an  additional
amount  for  one year of health insurance coverage.  The  Company
has  certain  rights to extend the agreements and payments  under
the  Agreement for a total of 24 months after termination  of  an
Executive's  employment.  In the event the Executive  should  die
during  the  payment  period,  the Company's  payment  obligation
immediately  terminates.  In May 1998, Mr. Knutson  resigned  his
employment and has received payments under this Agreement for the
immediate twelve month period thereafter.



Compensation of Directors

In  fiscal  1997, the Company established a policy to  grant  all
current  directors who are not employees (other than Mr.  Ahrens,
who  is a founder of the Company) a nonqualified stock option for
15,000 shares vesting at the rate of 3,000 shares at the next and
each  of  the subsequent four annual shareholder meetings.   This
option  is  intended  to provide the outside  director  with  the
equivalent  of  an annual grant of 3,000 shares and  the  Company
does not anticipate granting any additional options until the end
of  the fifth year.  The exercise price of these options will  be
set  at the fair market value of the Common Stock on the date  of
the grant.

Since fiscal 1998, the Company has provided directors who are not
employees  of the Company an annual fee of $4,000.   The  Company
also established a policy to grant all new directors who are  not
employees a one-time nonqualified stock option for 10,000  shares
which  vests  immediately.   Thus,  new  directors  who  are  not
employees of the Company will receive this 10,000 share option in
addition  to  the  ongoing 15,000 share option  described  above.
Like  the 15,000 share option, the exercise price of the  options
will  be set at the fair market value of the Common Stock on  the
date of grant.
<PAGE> 47


       ITEM 12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL
                      OWNERS AND MANAGEMENT

The following table sets forth the number of shares of Common
Stock and percentage of outstanding shares of Common Stock of the
Company owned as of April 1, 1999, by persons who hold of record
or are known to beneficially own 5% or more of the outstanding
common stock of the Company, each nominee and director of the
Company, the Named Persons and all officers, key employees and
directors as a group.

<TABLE>
<CAPTION>
<S><C>                    <C>                  <C>

                          Amount and Nature
Name and Address of          Beneficial         Percent
Beneficial Owner             Ownership          of Class
- -------------------       -----------------     --------
Paul C. Ahrens              1,405,491(1)          9.9%
1290 Industrial Way
Albany, OR

M. ("Sreeni")
Sreenivasan                  604,154(2)           4.2%(3)


Howard L. Farkas             106,000(4)             *

Edward M. Giles              274,000(5)           1.9%(3)

Page E. Golsan, III           44,000(6)             *

Donald M. Kuhla, Ph.D.        17,000(7)             *

Charles B. Williams          253,620(8)           1.8%(3)

Timothy D. Fitzpatrick        25,500(9)             *

Mitchell R. McVay             26,100(10)            *

Brown Capital Management   1,035,800(11)          7.3%
809 Cathedral Street
Baltimore, MD  21201

All Officers, Key        2,755,865(1)(2)(4)(5)   18.9%(3)
Employees and Directors (6)(7)(8)(9)(10)(12)
as a Group (10 persons)
</TABLE>
<PAGE> 48
______________________
*less than 1%.
(1)Includes  6,000  shares of common stock  which  are  owned  of
 record  by  a  private foundation of which  Mr.  Ahrens  is  the
 President.  Mr. Ahrens disclaims beneficial ownership  of  these
 shares.
(2)Includes  105,113 shares of common stock which Mr. Sreenivasan
 has  the right to acquire immediately or within sixty (60)  days
 pursuant  to employee stock options.  Excludes 12,000 shares  of
 common  stock  issuable pursuant to stock options  held  by  Mr.
 Sreenivasan which are not exercisable now or within  sixty  (60)
 days.
(3)The denominator used in calculating the percentage is equal to
 the  number of shares outstanding plus the number of shares  the
 beneficial owner (or group of beneficial owners) has a right  to
 acquire  immediately or within sixty days pursuant  to  warrants
 or options.
(4)Includes  56,000 shares of common stock which Mr.  Farkas  has
 the  right  to  acquire immediately or within  sixty  (60)  days
 pursuant to stock options.  Mr. Farkas disclaims ownership  over
 50,000  shares of common stock held in his name which have  been
 pledged as security for a loan and over which Mr. Farkas has  no
 voting  control.  Excludes 9,000 shares of common stock issuable
 pursuant  to  stock  options held by Mr. Farkas  which  are  not
 exercisable now or within sixty (60) days.
(5)Includes 13,000 shares of common stock which Mr. Giles has the
 right  to acquire immediately or within sixty (60) days pursuant
 to  stock  options.   Excludes 12,000  shares  of  common  stock
 issuable  pursuant to stock options held by Mr. Giles which  are
 not  exercisable now or within sixty (60) days.   Also  includes
 60,000  shares of common stock held by two individuals who  have
 granted  to  Mr.  Giles  the investment powers  associated  with
 these  shares.   Mr. Giles disclaims beneficial  ownership  over
 these 60,000 shares.
(6)Includes 6,000 shares of common stock which Mr. Golsan has the
 right  to acquire immediately or within sixty (60) days pursuant
 to  stock  options.   Excludes  9,000  shares  of  common  stock
 issuable pursuant to stock options held by Mr. Golsan which  are
 not exercisable now or within sixty (60) days.
(7)Includes 13,000 shares of common stock which Dr. Kuhla has the
 right  to acquire immediately or within sixty (60) days pursuant
 to  stock  options.   Excludes 12,000  shares  of  common  stock
 issuable  pursuant to stock options held by Dr. Kuhla which  are
 not exercisable now or within sixty (60) days.
(8)Includes 61,500 shares of common stock which Mr. Williams  has
 the  right  to  acquire immediately or within  sixty  (60)  days
 pursuant  to employee stock options.  Excludes 9,500  shares  of
 common  stock  issuable pursuant to stock options  held  by  Mr.
 Williams  which  are not exercisable now or  within  sixty  (60)
 days.
(9)Includes  25,500 shares of common stock which Mr.  Fitzpatrick
 has  the right to acquire immediately or within sixty (60)  days
 pursuant  to employee stock options.  Excludes 30,000 shares  of
 common  stock  issuable pursuant to stock options  held  by  Mr.
 Fitzpatrick which are not exercisable now or within  sixty  (60)
 days.
(10)Includes  26,000 shares of common stock which Mr.  McVay  has
 the  right  to  acquire immediately or within  sixty  (60)  days
 pursuant  to employee stock options.  Excludes 9,500  shares  of
 common  stock  issuable pursuant to stock options  held  by  Mr.
 McVay which are not exercisable now or within sixty (60) days.
(11)Based  on  Schedule 13(g) filings, pursuant  to  which  Brown
 Capital  Management  disclosed controlling 1,035,800  shares  of
 common  stock  with sole dispositive power.   Of  these  shares,
 Brown  Capital  Management further disclosed that  it  had  sole
 voting power over 971,500 shares of common stock.
(12)Excludes  10,000 shares of common stock issuable pursuant  to
 stock  options  held by Mr. Melka which are not exercisable  now
 or within sixty (60) days.






           ITEM 13.  CERTAIN RELATIONSHIPS AND RELATED
                          TRANSACTIONS

Not applicable.

<PAGE> 49

                             PART IV

      ITEM 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND
                       REPORTS ON FORM 8-K

(a)(1)  and  (2)  FINANCIAL STATEMENTS  AND  FINANCIAL  STATEMENT
SCHEDULES.

The information required by this item is included under Item 8 of
this Report.

(a)(3)    EXHIBITS.

The  following documents are filed as part of this Annual  Report
on Form 10-K:

3(i)(1) Articles   of  Incorporation  of  Synthetech,  Inc.,   as
        amended.

3(ii)(6)Bylaws of Synthetech, Inc., as amended.

4(7)    Synthetech,  Inc.  and American Securities  Transfer  and
        Trust, Inc. Rights Agent, Rights Agreement dated July 23,
        1998.

10.1(2),(3) Supply   Agreement   dated  January   3,   1989   between
            Synthetech, Inc. and Biomeasure, Incorporated.

10.2(2),(3) License   Agreement  dated  January   3,   1989   between
            Synthetech, Inc. and Biomeasure, Incorporated.

10.3(4)+ Synthetech, Inc. 1990 Stock Option Plan.

10.4(5) Amendment  No. 1 to Stock and Warrant Purchase  Agreement
        between the Company and JB dated as of March 26, 1996.

10.5(6) 1995 Incentive Compensation Plan, as amended.

10.6    Promissory  Note  dated August 26, 1998 from  Synthetech,
        Inc. to United States National Bank of Oregon.

10.7    Letter   Agreement   dated  August   26,   1998   between
        Synthetech,  Inc.  and  United States  National  Bank  of
        Oregon.

10.8(6) Nonqualified Stock Option dated as of November 7, 1996 to
        purchase  50,000 shares of Common Stock issued to  Howard
        L. Farkas.

10.9(6) Nonqualified Stock Option dated as of November 7, 1996 to
        purchase  15,000 shares of Common Stock issued to  Howard
        L. Farkas.

10.10(6)Nonqualified Stock Option dated as of November 7, 1996 to
        purchase 15,000 shares of Common Stock issued to Page  E.
        Golsan III.

<PAGE> 50

10.11(6)+ Form  of  contract entered into by each of Mr. Philip  L.
          Knutson,  Mr. M. Sreenivasan and Mr. Charles B.  Williams
          dated July 18, 1997.

10.12+  Bonus for M. Sreenivasan granted October 1, 1998.

10.13   Contract  entered  into  by  Synthetech,  Inc.  and  R.L.
        Reimers Company dated December 1, 1998.

23      Consent of Arthur Andersen LLP.

27      Financial Data Schedule for Twelve Months Ended March 31,
        1998.

__________________________

+ Management contract or compensatory plan.

(1)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1991.

(2)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1990.

(3) Confidential treatment of certain portions of this document was
granted  by  the  Commission on January 10, 1990  (File  No.  33-
27566).

(4)  Incorporated by reference to Exhibit A to the definitive  copy
of  registrant's Proxy Statement (dated October 23, 1990) for the
1990 Annual Meeting of Shareholders.

(5)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1996.

(6)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1997.

(7) Incorporated   by   reference  to  the   exhibits   filed   with
registrant's Current Report on Form 8-K for July 24, 1998.

(b)  Reports on Form 8-K

     None.

(c)  See (a) (3) above.

(d)  See (a) (1) and (2) above.
<PAGE> 51
                           SIGNATURES

Pursuant  to  the  requirements of Section 13  or  15(d)  of  the
Securities  Exchange Act of 1934, the Registrant has duly  caused
this  Report  to  be  signed on its behalf  by  the  undersigned,
thereunto duly authorized.

Date:  June __, 1999           SYNTHETECH, INC.
                               (Registrant)

                               By
                                  M. ("Sreeni") Sreenivasan
                                  President and Chief
                                  Executive Officer
Pursuant  to the requirements of the Securities Exchange  Act  of
1934,  this Report has been signed below by the following persons
on  behalf  of the Registrant and in the capacities  and  on  the
dates indicated.
<TABLE>
<CAPTION>
<S><C>              <C>                                <C>
     Signature                   Title                  Date

__________________  President, Chief Executive        June 9,
   M. ("Sreeni")    Officer (Principal Executive        1999
    Sreenivasan     Officer) and Director

__________________  Vice President of Finance and     June 9,
Charles B. Williams Administration, Chief Financial     1999
                    Officer, Secretary, Treasurer
                    (Principal Financial Officer
                    and Principal Accounting
                    Officer), and Director

___________________ Chairman of the Board             June 9,
  Paul C. Ahrens                                        1999

___________________ Director
 Howard L. Farkas                                    June 9,
                                                        1999

___________________ Director                          June 9,
  Edward M. Giles                                       1999

___________________ Director                          June 9,
Page E. Golsan, III                                     1999

____________________ Director                          June 9,
 Donald M. Kuhla,                                       1999
       Ph.D.
</TABLE>
___________
<PAGE> 52


                        INDEX TO EXHIBITS
                                              Sequential Page No.

3(i)(1)1   Articles  of  Incorporation of Synthetech,
           Inc., as amended

3(ii)(6)   Bylaws of Synthetech, Inc., as amended

4(7)       Synthetech,  Inc.  and American Securities  Transfer  and
           Trust, Inc. Rights Agent, Rights Agreement dated July 23,
           1998.

10.1(2),(3)Supply  Agreement dated  January  3,  1989
           between  Synthetech, Inc. and  Biomeasure,
           Incorporated.

10.2(2),(3)License  Agreement dated January  3,  1989
           between  Synthetech, Inc. and  Biomeasure,
           Incorporated.

10.3(4)+   Synthetech, Inc. 1990 Stock Option Plan.

10.4(5)    Amendment  No.  1  to  Stock  and  Warrant
           Purchase Agreement between the Company and
           JB dated as of March 26, 1996.

10.5(6)   1995   Incentive  Compensation  Plan,   as
          amended.

10.6      Promissory Note dated August 26, 1998 from
          Synthetech, Inc. to United States National
          Bank of Oregon.

10.7      Letter  Agreement dated  August  26,  1998
          between Synthetech, Inc. and United States
          National Bank of Oregon.

10.8(6)   Nonqualified  Stock  Option  dated  as  of
          November   7,  1996  to  purchase   50,000
          shares of Common Stock issued to Howard L.
          Farkas.

10.9(6)   Nonqualified  Stock  Option  dated  as  of
          November 7, 1996 to purchase 15,000 shares
          of   Common  Stock  issued  to  Howard  L.
          Farkas.

10.10(6)  Nonqualified  Stock  Option  dated  as  of
          November 7, 1996 to purchase 15,000 shares
          of  Common Stock issued to Page E.  Golsan
          III.

10.11(6)+ Form  of contract entered into by each  of
          Mr.  Philip L. Knutson, Mr. M. Sreenivasan
          and Mr. Charles B. Williams dated July 18,
          1997.

10.12+    Bonus    for   M.   Sreenivasan    granted
          October 1, 1998.

10.13   Contract entered into by Synthetech,  Inc.
        and R.L. Reimers Company dated December 1,
        1998.

23      Consent of Arthur Andersen LLP.

27      Financial Data Schedule for Twelve Months Ended March 31,
        1999.

<PAGE> 53

__________________________

+ Management contract or compensatory plan.

(1)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1991.

(2)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's Annual Report on Form 10-K for the fiscal year ended
March 31, 1990.

(3) Confidential treatment of certain portions of this document was
granted  by  the  Commission on January 10, 1990  (File  No.  33-
27566).

(4)  Incorporated by reference to Exhibit A to the definitive  copy
of  registrant's Proxy Statement (dated October 23, 1990) for the
1990 Annual Meeting of Shareholders.

(5)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1996.

(6)   Incorporated  by  reference  to  the  exhibits   filed   with
registrant's  Annual Report on Form 10-KSB for  the  fiscal  year
ended March 31, 1997.

(7)   Incorporated   by   reference  to  the   exhibits   filed   with
registrant's Current Report on Form 8-K for July 24, 1998.


<PAGE> 54



                                                     Exhibit 10.6
                                                     of Form 10-K
                         PROMISSORY NOTE

PrincipalLoan DateMaturityLoan No.    Call CollateralAccount
Officer Initials
$1,000,00008-26-1998          18/26   019      10  8741855333
RGS09
References in the shaded area are for Lender's use only and do
not limit the applicability of this document to an particular
loan or item

Borrower:Synthetech, Inc.    Lender:   U.S. Bank National Association
        1290 Industrial Way        Greater Willamette Business Banking Center
        Albany, OR 97321           PL-7 Oregon Commercial Loan Servicing
                                   555 S. W. Oak
                                   Portland, OR 97204

Principal Amount: $1,000,000.00  Initial Rate: 8.500%
Date of Note: August 26, 1998

PROMISE TO PAY. Synthetech, Inc. ("Borrower") promises to pay to
U. S. BANK NATIONAL ASSOCIATION ("Lender"), or order, In lawful
money of the united States of America, on demand, the principal
amount of One Million & 00/100 Dollars ($1,000,000.00) or so much
as may be outstanding, together with Interest on the unpaid
outstanding principal balance of each advance. Interest shall be
calculated from the date of each advance until repayment of each
advance.

PAYMENT. Borrower will pay this loan Immediately upon Lender's
demand. In addition, Borrower will pay regular monthly payments
of all accrued unpaid Interest due as of each payment date,
beginning September 30, 1998, with all subsequent interest
payments to be due on the last day of each month after that. The
annual interest rate for this Note is computed on a 365/360
basis; that is, by applying the ratio of the annual interest rate
over a year of 360 days, multiplied by the outstanding principal
balance, multiplied by the actual number of days the principal
balance is outstanding. Borrower will pay Lender at lender's
address shown above or at such other place as Lender may
designate in writing.

VARIABLE INTEREST RATE. The interest rate on this Note is subject
to change from time to time based on changes in an index which is
the Lender's Prime Rate. This is the rate of interest which
Lender from time to time establishes as its Prime Rate and is
not, for example, the lowest rate of interest which Lender
collects from any borrower or class of borrowers (the "Index").
The interest rate shall be adjusted without notice effective on
the day Lender's prime rate changes. Lender will tell Borrower
the current Index rate upon Borrower's request. Borrower
understands that Lender may make loans based on other rates as
well. The interest rate change will not occur more often than
each Day. The Index currently Is 8.500% per annum. The Interest
rate to be applied to the unpaid principal balance of this Note
will be at a rate equal to the Index, resulting in an Initial
rate of 8.500% per annum.

 PREPAYMENT. Borrower agrees that all loan fees and other prepaid
finance charges are earned fully as of the date of the loan and
will not be subject to refund upon early payment (whether
voluntary or as a result of default), except as otherwise
required by law.

Except for the foregoing, Borrower may pay without penalty all or
a portion of the amount owed earlier than it is due. Early
payments will not, unless agreed to by Lender in writing, relieve
Borrower of Borrower's obligation to continue to make payments of
accrued unpaid interest. Rather, they will reduce the principal
balance due.

DEFAULT. Borrower will be in default if any of the following
happens: (a) Borrower fails to make any payment when due. (b)
Borrower breaks any
promise Borrower has made to Lender, or Borrower fails to comply
with or to perform when due any other term, obligation, covenant,
or condition contained in this Note or any agreement related to
this Note, or in any other agreement or loan Borrower has with
Lender. (c) Any representation or statement made or furnished to
Lender by Borrower or on Borrower's behalf is false or misleading
in any material respect either now or at the time made or
furnished. (d) Borrower becomes insolvent, a receiver is
appointed for any part of Borrower's properly, Borrower makes an
assignment for the benefit of creditors, or any proceeding is
commenced either by Borrower or against Borrower under any
bankruptcy or insolvency laws. (e) Borrower is in default under
any other note, security agreement, lease agreement or lease
schedule, loan agreement or other agreement, whether now existing
or hereafter made, between Borrower and U.S. Bancorp or any
direct or indirect subsidiary of U.S. Bancorp (f) Any creditor
tries to take any of Borrower's property on or in which Lender
has a lien or security interest. This includes a garnishment of
any of Borrower's accounts with Lender. (g) Any guarantor dies or
any of the other events described in this default section occurs
with respect to any guarantor of this Note. (h) A material
adverse change occurs in Borrower's financial condition, or
Lender believes the prospect of payment or performance of the
Indebtedness is impaired. (i) Lender in good faith deems itself
insecure.

LENDER'S RIGHTS. Upon default, Lender may declare the entire
unpaid principal balance on this Note and all accrued unpaid
interest immediately due, without notice, and then Borrower will
pay that amount. Upon default, including failure to pay upon
final maturity, Lender, at its option, may also, if permitted
under applicable law, increase the variable interest rate on this
Note to 5,000 percentage points over the Index. The interest rate
will not exceed the maximum rate permitted by applicable law.
Lender may hire or pay someone else to help collect this Note if
Borrower does not pay. Borrower also will pay Lender that amount.
This includes, subject to any limits under applicable law,
Lender's attorneys' fees and Lender's legal expenses whether or
not there is a lawsuit, including attorneys' fees and legal
expenses for bankruptcy proceedings (including efforts to modify
or vacate any automatic stay or injunction), appeals, and any
anticipated post-judgment collection services. II not prohibited
by applicable law, Borrower also will pay any court costs, in
addition to all other sums provided by law. This Note has been
delivered to Lender and accepted by Lender in the State of
Oregon. If there Is a lawsuit, Borrower agrees upon Lender's
request to submit to the jurisdiction of the courts of Multnomah
County, the State of Oregon. Subject to the provisions on
arbitration, this Note shall be governed by and construed In
accordance with the laws of the State of Oregon.

RIGHT OF SETOFF. Borrower grants to Lender a contractual
possessory security interest in, and hereby assigns, conveys,
delivers, pledges, and transfers to Lender all Borrower's right,
title and interest in and to, Borrower's accounts with Lender
(whether checking, savings, or some other account), including
without limitation all accounts held jointly with someone else
and all accounts Borrower may open in the future, excluding
however all IRA and Keogh accounts, and all trust accounts for
which the grant of a security interest would be prohibited by
law. Borrower authorizes Lender, to the extent permitted by
applicable law, to charge or setoff all sums owing on this Note
against any and all such accounts.

LINE OF CREDIT. This Note evidences a revolving line of credit.
Advances under this Note, as well as directions for payment from
Borrower's accounts, may be requested orally or in writing by
Borrower or by an authorized person. Lender may. but need not.
require that all oral requests be confirmed in writing. Borrower
agrees to be liable for all sums either: (a) advanced in
accordance with the instructions of an authorized person or (b)
credited to any of Borrower's accounts with Lender,

<PAGE> 55

regardless of the fact that persons other than those authorized
to borrow have authority to draw against the accounts. The unpaid
principal balance owing on this Note at any time may be evidenced
by endorsements on this Note or by Lender's internal records,
including daily computer print-outs. Lender will have no
obligation to advance funds under this Note if: (a) Borrower or
any guarantor is in default under the terms of this Note or any
agreement that Borrower or any guarantor has with Lender,
including any agreement made in connection with the signing of
this Note; (b) Borrower or any guarantor ceases doing business or
is insolvent; (c) any guarantor seeks, claims or otherwise
attempts to limit, modify or revoke such guarantor's guarantee of
this Note or any other loan with Lender; (d) Borrower has applied
funds provided pursuant to this Note for purposes other than
those authorized by Lender; or (e) Lender in good faith deems
itself insecure under this Note or any other agreement between
Lender and Borrower.

ARBITRATION. Lender and Borrower agree that all disputes, claims
and controversies between them, whether Individual, joint, or
class In nature, arising from this Note or otherwise, Including
without limitation contract and tort disputes, shall be
arbitrated pursuant to the Rules of the American Arbitration
Association, upon request of either party. No act to take or
dispose of any collateral securing this Note shall constitute a
waiver of this arbitration agreement or be prohibited by this
arbitration agreement. This includes, without limitation,
obtaining injunctive relief or a temporary restraining order;
foreclosing by notice and sale under any deed of trust or
mortgage; obtaining a writ of attachment or imposition of a
receiver; or exercising any rights relating to personal property,
including taking or disposing of such property with or without
judicial process pursuant to Article 9 of the Uniform Commercial
Code. Any disputes, claims, or controversies concerning the
lawfulness or reasonableness of any act, or exercise of any
right, concerning any collateral securing this Note, including
any claim to rescind, reform, or otherwise modify any agreement
relating to the collateral securing this Note, shall also be
arbitrated, provided however that no arbitrator shall have the
right or the power to enjoin or restrain any act of any party.
Judgment upon any award rendered by any arbitrator may be entered
in any court having jurisdiction. Nothing in this Note shall
preclude any party from seeking equitable relief from a court of
competent jurisdiction. The statute of limitations, estoppel.
waiver, laches, and similar doctrines which would otherwise be
applicable in an action brought by a party shall be applicable in
any arbitration proceeding, and the commencement of an
arbitration proceeding shall be deemed the commencement of an
action for these purposes. The Federal Arbitration Act shall
apply to the construction, interpretation, and enforcement of
this arbitration provision.

LATE CHARGE. If a payment is 19 days or more past due, Borrower
will be charged a late charge of 5% of the delinquent payment.

PERIODIC REVIEW. Lender will review the loan periodically. At the
time of the review, Borrower will furnish Lender with any
additional information regarding Borrower's financial condition
and business operations that Lender requests. This information
may include, but is not limited to, financial statements, tax
returns. lists of assets and liabilities, agings of receivables
and payables, inventory schedules, budgets and forecasts. If upon
review, Lender, in its sole discretion, determines that there has
been a material adverse change in Borrower's financial condition,
Borrower will be in default. Upon default, Lender shall have all
rights specified herein.

DEMAND NOTE. BORROWER ACKNOWLEDGES AND AGREES THAT (A) THIS NOTE
IS A DEMAND NOTE, AND LENDER IS ENTITLED TO



08-26-1998               PROM1SSORY NOTE         Page 2
                           (Continued)

DEMAND NOTE.  BORROWER ACKNOWLEDGES AND AGREES THAT (A) THIS NOTE
IS A DEMAND NOTE, AND LENDER IS ENTITLED TO DEMAND BORROWER'S
IMMEDIATE PAYMENT IN FULL OF ALL AMOUNTS OWING HEREUNDER, (B)
NEITHER ANYTHING TO THE CONTRARY CONTAINED HEREIN OR IN ANY OTHER
LOAN DOCUMENTS (INCLUDING BUT NOT LIMITED TO, PROVISIONS RELATING
TO DEFAULTS, RIGHTS OF CURE, DEFAUL T RATE OF INTEREST,
INSTALLMENT PAYMENTS, LATE CHARGES, PERIODIC REVIEW OF BORROWER'S
FINANCIAL CONDITIONS, AND COVENANTS) NOR ANY ACT OF LENDER
PURSUANT TO ANY SUCH PROVISIONS SHALL LIMIT OR IMPAIR LENDER'S
RIGHT OR ABILITY TO REQUIRE BORROWER'S PAYMENT IN FULL OF ALL
AMOUNTS OWING HEREUNDER IMMEDIATEL Y UPON LENDER'S DEMAND, AND
(C) UPON LENDER MAKING ANY SUCH DEMAND, LENDER SHALL HAVE NO
OBLIGATION TO MAKE ANY ADVANCE UNDER THIS NOTE OR UNDER THE LOAN
DOCUMENTS.

CREDIT  ACT- CHECKING ACCOUNT NUMBER xxxxxxxxxxxxx. Borrower  has
requested  and  been granted Lender's Commercial Line  of  Credit
Automatic Cash Transfer Service ("Credit ACT"). So long  as  this
Note  is  in  place,  Borrower authorizes  Lender  to  draw  from
Borrower's   available  line  of  credit   and   transfer   funds
automatically to Borrower's commercial checking account described
in   the  heading  of  this  paragraph  ("Checking  Account")  in
accordance  with  this section. So long as this agreement  is  in
place,  Lender  agrees to make an automatic  cash  transfer  from
Borrower's  line of credit to its Checking Account in  increments
of $500.00, to paychecks that would otherwise overdraw Borrower's
Checking  Account by $100.00 or more, up to Borrower's  available
credit limit. The amount of each Credit ACT transfer will  be  an
advance  under  the terms of this Note. There is  no  charge  for
using Credit ACT. Borrower agrees to pay prevailing overdraft  or
other  applicable checking account charges then in effect  if  an
overdraft  may  not  be  paid because  an  ACT  in  the  required
increment  of  $500.00 to pay the full amount  of  the  overdraft
would  exceed Borrower's credit limit. If Borrower's credit limit
has  been exceeded, and no other ACT privileges are available  to
Borrower,  any check presented for payment from Checking  Account
will,  at  the  sole  option  of Lender,  either  be  paid,  thus
overdrawing  Checking Account, or dishonored. Lender  may  change
the  terms  of Credit ACT at any time by giving Borrower  written
notice,  sent  to  the Borrower's address as  shown  in  Lender's
records, prior to the effective date of the change.

Lender reserves the right to discontinue this service upon giving
written  notice to the Borrower, at Borrower's address  shown  in
the  Lender's  records, under the following circumstances:  (  1)
Lender  reasonably  believes that, Borrower  will  be  unable  to
fulfill  its repayment obligations because of a material  adverse
change in Borrower's financial circumstances. (2) Borrower  fails
to   promptly  provide  financial  information  that  Lender  has
requested. (3) Borrower is in default of a material provision  of
any promissory note loan agreement with Lender.

If  Lender discontinues further Credit ACT services due to any of
these circumstances, Lender will mail Borrower written notice  of
the  discontinuation and the reasons therefor. After such  notice
is given, Borrower must request in writing that its Credit ACT be
reinstated.  Before Credit ACT privileges are reinstated,  Lender
may  ask  Borrower  to  provide new  information,  at  Borrower's
expense.  If  Borrower shows Lender that the  circumstances  that
caused  cancellation of Credit ACT services have ceased to exist,
Credit  ACT  will  be  reinstated at  Lender's  sole  option  and
discretion upon written notice to Borrower.

RENEWAL  AND  EXTENSION.  This  Note  is  given  in  renewal  and
extension   and  not  in  novation  of  the  following  described
indebtedness.  That  certain Promissory Note dated  September  8,
1995  in the amount of $1,000,000.00 executed by Borrower payable
to Lender.

GENERAL PROVISIONS. This Note is payable on demand. The inclusion
of  specific  default provisions or rights of  Lender  shall  not
preclude  Lender's right to declare payment of this Note  on  its
demand. Lender may delay or forgo enforcing any of its rights  or
remedies  under this Note without losing them. Borrower  and  any
other person who signs, guarantees or endorses this Note, to  the
extent  allowed  by law, waive presentment, demand  for  payment,
protest  and notice of dishonor. Upon any change in the terms  of
this  Note, and unless otherwise expressly stated in writing,  no
party   who   signs  this  Note,  whether  as  maker,  guarantor,
accommodation   maker  or  endorser,  shall  be   released   from
liability. All such parties agree that Lender may renew or extend
(repeatedly and for any length of time) this loan, or release any
party or guarantor or collateral; or impair, fail to realize upon
or perfect Lender's security interest in the collateral; and take
any other action deemed necessary by Lender

<PAGE> 56

without the consent of or notice to anyone. All such parties also
agree that Lender may modify this loan without the consent of  or
notice  to anyone other than the party with whom the modification
is made.

UNDER  OREGON LAW MOST AGREEMENTS, PROMISES AND COMMITMENTS  MADE
BY  US  (LENDER) AFTER OCTOBER 3, 1989 CONCERNING LOANS AND OTHER
CREDIT EXTENSIONS WHICH ARE NOT FOR PERSONAL FAMIL Y OR HOUSEHOLD
PURPOSES OR SECURED SOLEL Y BY THE BORROWER'S RESIDENCE  MUST  BE
IN  WRITING,  EXPRESS CONSIDERATION AND BE SIGNED  BY  US  TO  BE
ENFORCEABLE.

PRIOR TO SIGNING THIS NOTE, BORROWER READ AND UNDERSTOOD ALL  THE
PROVISIONS  OF  THIS NOTE, INCLUDING THE VARIABLE  INTEREST  RATE
PROVISIONS.  BORROWER  AGREES  TO  THE  TERMS  OF  THE  NOTE  AND
ACKNOWLEDGES RECEIPT OF A COMPLETED COPY OF THE NOTE.

BORROWER:
Synthetech, Inc.

X  /s/   M.  Sreenivasan, President    X/s/Charles B. Williams, Vice President
         Authorized Officer                Authorized Officer

LENDER:
U. S. BANK NATIONAL ASSOCIATION

BY:/s/ ______________
      Authorized Officer




<PAGE> 57



                                                     Exhibit 10.7
                                                     to Form 10-K

August 26, 1998

Charles B. Williams
Synthetech, Inc.
1290 Industrial Way
PO Box 646
Albany OR 97321


Dear Mr. Williams:

U.  S. Bank National Association has approved the renewal of  the
revolving line of credit under the terms and conditions  outlined
below.   In addition to this approval, I would like to extend  an
invitation  for  discussions  in expanding  our  current  banking
relationship.  As your plans for equipment and buildings develop,
please don't hesitate to call.  I look forward to the opportunity
to demonstrate U.S. Bank's ability to meet your banking needs and
contribute to the success of Synthetech, Inc.

Borrower:            Synthetech, Inc.

Guarantor:           None

Maximum Loan Amount: $1,000,000

Purpose:             General corporate purposes.

Interest Rate:       Fully  floating variable interest rate equal
                     to  U.S.  Bank's  prime rate.   U.S.  Bank's
                     prime  rate  is  the rate of interest  which
                     U.S.  Bank from time to time establishes  as
                     its  prime rate and is not, for example, the
                     lowest  rate  of  interest which  U.S.  Bank
                     collects  from  any  borrower  or  class  of
                     borrowers.   All interest shall be  computed
                     on  the  basis  of a 360-day  year  and  the
                     actual number of days elapsed.

Loan  Fee:           Non-refundable upfront annual loan  fee  of
                     $1,250.

<PAGE> 58

Loan Advances:       Advances  may be requested by Borrower  from
                     time  to  time in accordance with the  terms
                     of the promissory note.

                     All  advances  shall be  made  at  the  sole
                     option  of U.S. Bank.  U.S. Bank may decline
                     to  make any advances and may terminate  the
                     availability of advances at any time.

Maturity Date:       Payable on demand.

Repayment:           Principal  and interest payable  on  demand.
                     Interest  payable  monthly  in  absence   of
                     demand.

Collateral:          Unsecured.

Insurance:           Borrower  shall maintain insurance  in  such
                     amounts  and  covering such  risks  as  U.S.
                     Bank shall require.

Financial Reporting: Annual   CPA  audited  financial   statement
                     within  90 days after the end of each fiscal
                     year.

                     At   any   time  requested  by  U.S.   Bank,
                     Borrower   shall   furnish  any   additional
                     information  regarding Borrower's  financial
                     condition and business operations that  U.S.
                     Bank   requests.    This   information   may
                     include,  but  is not limited to,  financial
                     statements,  tax  returns, lists  of  assets
                     and  liabilities, agings of receivables  and
                     payables,  inventory schedules, budgets  and
                     forecasts.

Loan Documentation:  Borrower  shall  deliver to U.S.  Bank  duly
                     executed  promissory note, deeds  of  trust,
                     mortgages,  security  agreements,  financing
                     statements,   loan  agreements,  guaranties,
                     borrower  authorizations,  attorney  opinion
                     letters    and   other   documents    ("Loan
                     Documents")  as  required by  U.S.  Bank  in
                     form  and  substance  satisfactory  to  U.S.
                     Bank and its counsel.

                     Non-Assignable:           This        credit
                     accommodation   may  not  be   assigned   by
                     Borrower.   No guarantor or any third  party
                     is  intended as a third-party beneficiary or
                     has any right to rely hereon.

Arbitration:         Borrower  and U.S. Bank hereby agree  to  be
                     bound   by  the  terms  of  the  Arbitration
                     clause attached hereto as Exhibit A.

Expenses:            Borrower shall reimburse U.S. Bank  for  all
                     out-of-pocket    expenses    incurred     in
                     connection  with  this credit  accommodation
                     upon    demand,   whether   or   not    this
                     transaction  closes  or  is  funded.    Such
                     expenses  shall include, without limitation,
                     attorney fees,
<PAGE> 59
                     title    insurance   fees,   travel   costs,
                     examination expenses, and filing fees.



This  letter  summarizes certain principal terms  and  conditions
relating  to  the loan and supersedes all prior oral and  written
negotiations, understandings, representations and agreements with
respect  to  the loan.  However, the Loan Documents will  include
additional   terms,   conditions,   covenants,   representations,
warranties  and  other  provisions which  U.S.  Bank  customarily
includes in similar transactions or which U.S. Bank determines to
be  appropriate  to  this  transaction.   Except  to  the  extent
modified by any other agreement, all terms, conditions, covenants
and  other provisions of this letter shall remain in effect until
the revolving line of  credit (including any renewals, extensions
or  modifications) is terminated and the loan balance is paid  in
full,  and by signing below, Borrower agrees to comply  with  all
such provisions.

In  addition  to the events of default in any Loan Document,  any
failure to comply with any term, condition or obligation in  this
letter  shall constitute an event of default under  each  of  the
Loan Documents.  The provisions of this letter shall survive  the
closing  of the loan and the execution and delivery of  the  Loan
Documents.   In the event of a conflict between this  letter  and
the  Loan  Documents,  the  terms of  the  Loan  Documents  shall
control.

Under Oregon law, most agreements, promises and commitments  made
by  lenders  after  October 3, 1989 concerning  loans  and  other
credit extensions which are not for personal, family or household
purposes or secured solely by the borrower's residence must be in
writing, express consideration and be signed by the lender to  be
enforceable.

If  the  above terms and conditions are acceptable to you, please
sign,  date  and return the acknowledgment copy of  this  letter,
together  with  the  non-refundable loan fee  in  the  amount  of
$1,250.

Sincerely,



Ron Sandrock
Relationship Manager
(503) 399-4143

Borrower  hereby accepts U. S. Bank's offer to extend  credit  on
the   terms  and  conditions  stated  above  and  agrees  to  the
Arbitration clause set forth in Exhibit A attached hereto.

                    Synthetech, Inc.

By:    _______________________________
Title: _______________________________
Date: _______________________________

<PAGE> 60

EXHIBIT A

ARBITRATION:   U.S.  Bank and Borrower agree that  all  disputes,
claims and controversies between them, whether individual, joint,
or  class  in  nature, arising from this letter or the  revolving
line   of  credit  or  otherwise,  including  without  limitation
contract and tort disputes, shall be arbitrated pursuant  to  the
Rules  of  the American Arbitration Association, upon request  of
either  party.   No  act  to take or dispose  of  any  collateral
securing  any loan shall constitute a waiver of this  arbitration
agreement.    This   includes,  without   limitation,   obtaining
injunctive  relief or a temporary restraining order;  foreclosing
by notice and sale under any deed of trust or mortgage; obtaining
a  writ  of attachment or imposition of a receiver; or exercising
any  rights  relating to personal property, including  taking  or
disposing  of  such  property with or  without  judicial  process
pursuant  to  Article  9  of the Uniform  Commercial  Code.   Any
disputes,  claims, or controversies concerning the lawfulness  or
reasonableness  or any act, or exercise of any right,  concerning
any collateral securing any loan, including any claim to rescind,
reform,  or  otherwise  modify any  agreement,  relating  to  the
collateral securing any loan, shall also be arbitrated,  provided
however that no arbitrator shall have the right or other power to
enjoin or restrain any act of any party.  Judgment upon any award
rendered  by  any arbitrator may be entered in any  court  having
jurisdiction.   Nothing  herein shall  preclude  any  party  from
seeking  equitable relief from a court of competent jurisdiction.
The statute of limitations, estoppel, waiver, laches, and similar
doctrines  which  would  otherwise be  applicable  in  an  action
brought  by  a  party  shall  be applicable  in  any  arbitration
proceeding,  and  the  commencement of an arbitration  proceeding
shall  be  deemed  the  commencement  of  any  action  for  these
purposes.   The  Federal  Arbitration  Act  shall  apply  to  the
construction, interpretation, and enforcement of this arbitration
provision.


<PAGE> 61


                                                    Exhibit 10.12
                                                     to Form 10-K


                              Bonus

On October 1, 1998, the Compensation Committee of the Board of
Directors granted Mr. Sreenivasan a one-time $45,000 bonus
payable in quarterly payments of $3,750 commencing on October 1,
1998 or payable on such other payment schedule as determined by
the Company for administrative convenience.  This bonus would terminate
upon termination of Mr. Sreenivasan's employment for any reason and,
accordingly, no further payments would be due thereafter.


<PAGE> 62

                                                    Exhibit 10.13
                                                     to Form 10-K

              THE AMERICAN INSTITUTE OF ARCHITECTS
                       AlA Document A 101

     Standard Form of Agreement Between Owner and Contractor
         where the basis  of payment is a STIPULATED SUM

                          1987 EDITION
  THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES; CONSULTATION
                              W'ITH
  AN ATTORNEY IS ENCOURAGED W'/TH RESPECT TO ITS COMPLETION OR
                          MODIFICATION.
The 1987 Edition of AlA Document A201. General Conditions of the
              Contract for Construction is adopted
  in this document by reference. Do not use with other general
          conditions unless this document is modified.
 This document has been approved and endorsed by The Associated
                 General Contractors of America.

AGREEMENT

made as of the   First                          day of December
in the year of
Nineteen Hundred and Ninety Eight

BETWEEN the Owner:       Synthetech, Inc.
(Name and address)       1290 Industrial Way
                         Albany, OR  97321

and the Contractor:      R.L. Reimers Company
(Name and address)       3939 Old Salem Road, Suite #200
                         Albany, OR  97321

The Project is:          Chemical Storage
(Name and address)       1290 Industrial Way
                         Albany, OR  97321

The Architect is:        IDC
(Name and address)       2020 SW Fourth Avenue, 3rd Floor
                         Portland, OR  97201

The Owner and Contractor agree as set forth below.

Copyright 1915, 1918,1925, 1937, 1951, 1958, 1961, 1963, 1967,
1974, 1977, @1987 by The American Institute of Architects, 1735
New York Avenue, N. W., Washington, D.C. 20006. Reproduction of
the material herein or substantial quotation of its provisions
without written permission of the AlA violates the copyright laws
of the United States and will be subject to legal prosecution.

AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                    A101.1987   1
WARNING: Unlicensed photocopying violates U.S. copyright laws and
                is subject to lega1 prosecution.
<PAGE> 63



                            ARTICLE 1
                     THE CONTRACT DOCUMENTS

The  Contract Documents consist of this Agreement, Conditions  of
the Contract ( General, Supplementary and other Conditions ).
Drawings,  Specifications, addenda issued prior to  execution  of
this  Agreement,  other documents listed in  this  Agreement  and
Modifications  issued  after execution of this  Agreement:  these
form  the: Contract. and are as full)' a part of the Contract  as
if  attached  to this Agreement Or repeated herein. The  Contract
represents  the  entire  and  integrated  agreement  between  the
parties hereto and supersedes prior negotiations. representations
or  agreements.  either written or oral. An  enumeration  of  the
Contract Documents. other than Modifications, appears in  Article 9

                            ARTICLE 2
                    THE WORK OF THIS CONTRACT
The  Contractor  shall execute the entire Work described  in  the
Contract  Documents, except to the extent specifically  indicated
in  the Contract Documents to be the responsibility of others, or
as follows:

     See attached Scope Letter
                            ARTICLE 3
         DATE OF COMMENCEMENT AND SUBSTANTIAL COMPLETION

3.1   The  date commencement is the date from which the  Contract
Time  of Paragraph 3.2 is measured, and shall be the date of this
Agreement,  as  first written above, unless a different  date  is
stated be1ow or provision is made for the date to be fixed  in  a
notice to proceed issued by the Owner.
(Insert the date of commencement. if it differs from the date  of
this  Agreement or, if applicable, state that the  date  will  be
fixed in a notice to proceed.)

Unless  the  date of commencement is established by a  notice  to
proceed  issued  by the Owner, the Contractor  shall  notify  the
Owner  in  writing not less than five days before commencing  the
Work  to permit the timely filing of mortgages, mechanic's  liens
and other security interests.

3.2   The Contractor shall achieve Substantial Completion of  the
entire Work not later than
(Insert  the calendar date or number of calendar days  after  the
date  of  commencement. Also insert any requirements for  earlier
Substantial Completion  of certain portions of the Work,  if  not
stated elsewhere in the Contract Documents.)

June 1 , 1999   Warehouse
February 5, 1999  Berm

subject to adjustments of this Contract Time as provided  in  the
Contract Documents.
(Insert   provisions, if any, for liquidated damages relating  to
failure to complete on time.)























AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                    A101.1987   2
WARNING: Unlicensed photocopying violates U.S. copyright laws and
                is subject to lega1 prosecution.
<PAGE> 64






                            ARTICLE 4
                          CONTRACT SUM

4.1   The Owner shall pay the Contractor in current funds for the
Contractor's performance of the Contract the Contract Sum of
(See  attached Bid breakdown)  Dollars, subject to additions  and
deductions as provided in the Contract Documents

4.2  The Contract Sum is based upon the following alternates,  if
any, which are described in the Contract Documents and are hereby
accepted by the Owner:
(State   the   numbers  or  other  identification   of   accepted
alternates. If decisions on other alternates are to  be  made  by
the Owner subsequent to the execution of this Agreement, attach a
schedule of such other alternates showing the amount for each and
the date until which that amount is valid.)

N/A

4.3  Unit prices, if any, are as follows:

  Imported rock $14.00 per ton
  Over excavation $7.50 per truck yard

























AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                    A101.1987   3
WARNING: Unlicensed photocopying violates U.S. copyright laws and
                is subject to lega1 prosecution.
<PAGE> 65


                            ARTICLE 5
                        PROGRESS PAYMENTS

5.1  Based upon Applications for Payment submitted to the
Architect by the Contractor and Certificates for Payment issued
by the Architect, the Owner shall make progress payments on
account of the Contract Sum to the Contractor as provided below
and elsewhere in the Contract Documents.

5.2  The period covered by each Application for Payment shall be
one calendar month ending on the last day of the month. or as
follows:


5.3   Provided an Application for Payment is received by the
owner not later than the First day of a month, the Owner shall
make payment to the Contractor not later than the tenth day of
the current month.  If an Application for Payment is received by
the Owner after the application date fixed above, payment shall
be made by the Owner not later  than ten days after the Owner
receives the Application for Payment.

5.4  Each Application for payment shall he based upon the
schedule of values submitted by the Contractor in accordance with
the Contact Documents.  The: schedule of values shall al1ocate
the entire Contract Sum among the various portions of the Work
and be prepared d in such form and supported  by such data to
substantiate its accuracy as the Architect may require. This
schedule, unless objected by the Architect, shall be used as
basis for reviewing the Contractor's Applications for Payment.

5.5  Applications for Payment shall indicate the percentage of
completion of each portion of the Work as of the end of the
period covered by the Application for Payment.

5.6  Subject to the provisions of the Contract Documents, the
amount of each progress payment shall he computed as follows:

5.6.1  Take that portion of the Contract Sum properly allocable
to completed Work as determined by. multiplying the percentage
completion of each portion of the Work by the share of the total
Contract Sum allocated to that portion of the Work in the
schedule of values, less retainage  of Five percent (5 % ).
Pending final determination of cost to the Owner of changes in
the Work, amounts not in the dispute may he included as provided
in Subparagraph 7.3.7. of the General Conditions even though the
Contract Sum has not yet been adjusted by Change Order;

5.6.2  Add that portion of the Contract Sum properly' allocable
to materials and equipment delivered and suitably stored at the
site for subsequent incorporation in the completed construction
(or, if approved in advance by the Owner, suitably stored off the
site at a 1ocation agreed upon in writing), less retainage of
Five percent (5 %);

5.6.3  Subtract the aggregate of previous payments made by the
Owner; and

5.6.4  Subtract amounts, if any, for which the Architect has
withheld or nullified a Certificate for Payment as provided by
Paragraph 9.5 of the General Conditions.

5.7  The progress payment amount determined in accordance with
Paragraph 5.6 shall be further modified under the following
circumstances:

5.7.1  Add, upon Substantial Completion of the Work, a sum
sufficient to increase the total payments to One hundred percent
(100 %) of the Contract Sum, less such amounts as the Architect
shall determine for incomplete Work and unsettled claims; and

5.7.2  Add, if final completion of the Work is thereafter
materially delayed through no fault of the Contractor, any
additional amounts payable in accordance with Subparagraph 9.10.3
of the General Conditions.

5.8  Reduction or limitation of retainage, if any, shall be as
follows:
(if it is intended, prior to Substantial Completion of the entire
Work, to reduce or limit the retainage resulting from the
percentages inserted in Subparagraphs 5.6.1 and 5.6.2 above, and
this is no1 explained elsewhere in the Contract Documents, insert
here provisions for such reduction or limitation.)













AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                    A101.1987   5
WARNING: Unlicensed photocopying violates U.S. copyright laws and
                is subject to lega1 prosecution.
<PAGE> 66



                            ARTICLE 6
                          FINAL PAYMENT

Final  payment,  constituting the entire unpaid  balance  of  the
Contract  Sum, shall be made by the Owner to the Contractor  when
(1)  the  Contract  has been fully performed  by  the  Contractor
except   for   the   Contractor's   responsibility   to   correct
nonconforming  Work  as provided in Subparagraph  12.2.2  of  the
General  Conditions  and to satisfy other requirements,  if  any,
which   necessarily  survive  final  payment;  and  (2)  a  final
Certificate  for  Payment has been issued by the Architect;  such
final  payment shall be made by the Owner not more than  30  days
after  the issuance of the Owner's final Certificate for Payment,
or as follows:

                            ARTICLE 7
                    MISCELLANEOUS PROVISIONS

7.1  Where reference is made in this Agreement to a provision  of
the   General  Conditions  or  another  Contract  Document,   the
reference refers to that provision as amended or supplemented  by
other provisions of  the Contract Documents.

7.2   Payments  due  and  unpaid under the  Contract  shall  bear
interest  from the date payment is due at the rate stated  below,
or in the absence thereof, at the legal rate prevailing from time
to time at the place where the Project is located.
(insert rate of interest agreed upon, If any)

  one and one-half% Per Month

(Usury  law's and requirements under the Federal Truth in Lending
Act,  similar  stale  and local consumer credit  laws  and  other
regulations at the Owner's and Contractor's principal  places  of
business,  the location of the Project and elsewhere  may  affect
the  validity of this provision. Legal advice should be  obtained
with  respect  to deletions or modifications, and also  regarding
requirements such a., written disclosures or waivers.)

7.3  Other provisions:


                            ARTICLE 8
                   TERMINATION OR  SUSPENSION

8.1  The Contract may be terminated by the Owner or the
Contractor as provided in Article 14 of the General Conditions.

8.2  The Work may be suspended by the Owner as provided in
Article 14 of the General Conditions.















AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                     A101.1987  5
WARNING: Unlicensed photocopying violates U.S. copyright laws and
                is subject to lega1 prosecution.
<PAGE> 67


                            ARTICLE 9
                ENUMERATION OF CONTRACT DOCUMENTS

9.1  The Contract Documents, except for Modifications issued
after execution of this Agreement, are enumerated as follows:

9.1.1  The Agreement is this executed Standard Form of Agreement
Between Owner and Contractor, AlA Document A101, 1987 Edition.

9.1.2  The General Conditions are the General Conditions of the
Contract for Construction, AlA Document A201 , 1987 Edition. The

9.1.3  Supplementary and other Conditions of the Contract are
those contained in the Project Manual dated
, and are as follows:


Document                       Title
Pages

See attached Scope Letter


9.1.4  The Specifications are those contained in the Project
Manual dated as in Subparagraph 9.1.3, and are as follows:
(Either list the. Specifications here or refer to an exhibit
attached to this Agreement.)

Section
Title
Pages

  See attached Table of Contents
























AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                     A101.1987  6
WARNING: Unlicensed photocopying violates U.S. copyright laws and
                is subject to lega1 prosecution.
<PAGE> 68


9.1.5  The Drawings are as follows. and are dated  9/25/98 unless
a different date is shown below:
(Either list the Drawings here or refer to an exhibit attached to
this Agreement:)

Number                   Title
Date

STC-0001       Cover Sheet and Legend
STC-0701       Underground Utilities
STC-0702       Grading and Site Surfaces
STC-7601       Details
STS-0000       Legend and Notes
STS-1-0-            Foundation Plan
STS-2-0             Framing Plan
STS-7600       Concrete Details
STS-7601       Conc/Steel Details
STS-7602       Conc/Steel Details                 9/28/98
STA-1-0-            Floor Plan
STA-2-0-            Roof Plan
STA-7400       Elevations and Sections
STA-7600       Chemical Storage Details
STE-0000       Electrical Legend
STE-7600       Electrical Details
STEL1-0             Electrical Lighting Plan
STEP1-0             Power Plan
STM-1-0-       HVAC Plan
STMP1-0-       Piping Plan
STLS1-0-       Floor Plan




9.1.6  The addenda, if any, are as follows:

Number                   Date                      Pages

N/A






















Portions of addenda relating to bidding requirements are not part
of the Contract Documents unless the bidding requirements are
also enumerated in this Article 9.

AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                     A101.1987  7
WARNING: Unlicensed photocopying violates U.S. copyright laws and
                is subject to lega1 prosecution.
<PAGE> 69

     9.1.7  Other documents, if any, forming part of the Contract
     Documents are as follows:
     (list here any additional documents which are intended to,
     form part of the Contract Documents.  The General Conditions
     provide that bidding requirements such as advertisement or
     invitation to bid.   Instructions to Bidders. sample forms
     and the Contractor's bid are not part of the Contract
     Documents unless enumerated in this Agreement.  They should
     be listed here only if intended to be part of the Contract
     Documents.)





















     This Agreement is entered into as of the day and year first
     written above and is executed in at least three original
     copies of which one is to be delivered to the Contractor,
     one to the Architect for use in the administration of the
     Contract, and the remainder to the Owner.


     OWNER                     CONTRACTOR

     ______________________        __________________________
     (Signature)                        (Signature)

     /s/ Charles B. Williams, VP & CFO  /s/ Ronald R. Reimers/President
     _______________________       ___________________________
     (Printed name and Title)           (Printed name and title)


     AIA CAUTION: You should sign an original AlA document which
     has this caution printed in red.  An original assures that
     changes will not be obscured as may occur when documents are
     reproduced.


AlA DOCUMENT A101 * OWNER-CONTRACTOR AGREEMENT * TWELFTH EDITION
* AlA * @1987
THE AMERICAN INSTITUTE OF ARCHITECTS, 1735 NEW YORK AVENUE, N.W.,
WASHINGTON, D.C. 20006

                                                     A101.1987  8
     WARNING: Unlicensed photocopying violates U.S. copyright
     laws and is subject to lega1 prosecution.


<PAGE> 70


                                                       Exhibit 23
                                                     to Form 10-K



            CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


As independent public accountants, we hereby consent to the
incorporation of our report dated May 14, 1999 included in this
Form 10-K for the year ended March 31, 1999, into Synthetech,
Inc.'s previously filed Registration Statement Nos. 33-45913 and
33-64621.


Arthur Andersen LLP
Portland, Oregon,
June 8, 1999

<PAGE>


<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
This schedule contains summary financial information extracted
from the March 31, 1999 10-K Balance Sheets, Statements of Income
and Cash Flow Statements, and is qualified in its entirety by
reference to such financial statements.
</LEGEND>

<S>                                   <C>
<PERIOD-TYPE>                         12-Mos
<FISCAL-YEAR-END>                     Mar-31-1999
<PERIOD-END>                          Mar-31-1999
<CASH>                                  7470000
<SECURITIES>                                  0
<RECEIVABLES>                           3429000
<ALLOWANCES>                              15000
<INVENTORY>                             3559000
<CURRENT-ASSETS>                       14665000
<PP&E>                                 11561000
<DEPRECIATION>                                0
<TOTAL-ASSETS>                         26230000
<CURRENT-LIABILITIES>                   2555000
<BONDS>                                       0
<COMMON>                                  14000
                         0
                                   0
<OTHER-SE>                             23027000
<TOTAL-LIABILITY-AND-EQUITY>           26230000
<SALES>                                23133000
<TOTAL-REVENUES>                       23133000
<CGS>                                  12983000
<TOTAL-COSTS>                          14792000
<OTHER-EXPENSES>                              0
<LOSS-PROVISION>                              0
<INTEREST-EXPENSE>                            0
<INCOME-PRETAX>                         8539000
<INCOME-TAX>                            3121000
<INCOME-CONTINUING>                     5418000
<DISCONTINUED>                                0
<EXTRAORDINARY>                               0
<CHANGES>                                     0
<NET-INCOME>                            5418000
<EPS-BASIC>                               .38
<EPS-DILUTED>                               .38


</TABLE>


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission