PHOTOGEN TECHNOLOGIES INC
S-3/A, EX-1.2, 2000-11-28
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                                                  November 20, 2000

BY FAX

Rochelle S.A.
38 Hertford Street
London, England W1Y 7TG
United Kingdom

Attn.:  James Martin

                  RE:      AMENDMENT TO LETTER AGREEMENT OF SEPTEMBER 18, 2000

Gentlemen:

         This is in reference to our Placement Agent Agreement dated September
18, 2000, regarding Rochelle's engagement as Photogen Technologies, Inc.'s
exclusive placement agent in connection with the proposed offering of its equity
securities pursuant to a Registration Statement under the Securities Act of
1933, as amended.

         After discussions, we have agreed to amend our Placement Agent
Agreement by adding a new subsection 1(d), as set forth below and by renumbering
the current subsection 1(d) as 1(e):

         (d)      The sale of Securities to an investor shall be on terms and
                  conditions mutually acceptable to the Company, Rochelle and
                  the investor, which shall include the following covenants that
                  shall be incorporated in the Purchase Agreement between the
                  Company and the investor:

                  (i)      Rochelle shall only solicit investors outside of the
                           United States, its territories and possessions and
                           then only to investors who are neither United States
                           citizens nor United States residents abroad;

                  (ii)     Resales of Securities by an investor in the
                           United States, its territories and possessions
                           shall be made in accordance with applicable
                           United States securities laws. In particular, so
                           long as any investor may be deemed to be an
                           underwriter under the Securities Act of 1933, as
                           amended, with respect to Securities purchased
                           thereunder, or if the investor sells his
                           Securities through or by an underwriter, the
                           resales of such Securities by such investor in
                           the United States, its territories or
                           possessions shall only be made by or through
                           broker/dealers registered under applicable
                           United States securities laws, and then only
                           pursuant to a post-effective amendment to the
                           Registration Statement

<PAGE>

Rochelle S.A.
November 20, 2000
Page 2

                           which shall include an appropriate prospectus
                           for use in connection with such resales. If such
                           resales constitute an "at the market"
                           distribution, they will be made in compliance
                           with Rule 415(a)(4). The Company shall require
                           an opinion of counsel to its satisfaction as to
                           whether such an investor may be deemed to be an
                           underwriter.

         If the foregoing correctly sets forth our understanding, please confirm
this by signing and returning to us a duplicate of this letter and our Placement
Agent Agreement of September 18, 2000 shall be amended accordingly as of the
date of your execution.


                                                     Sincerely,

                                                     Photogen Technologies, Inc.


                                                     By: /S/ TAFFY J. WILLIAMS
                                                         -----------------------
                                                              Taffy J. Williams
                                                              President and CEO

Agreed and accepted as of
the date below:

Rochelle SA


By: /s/ J.E. Martin
   ----------------------
Title: Director
      -------------------
Date: 27 November 2000
     --------------------


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